CN107802242A - Signal acquiring and processing apparatus and method for photoacoustic imaging - Google Patents
Signal acquiring and processing apparatus and method for photoacoustic imaging Download PDFInfo
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Abstract
The present invention provides a kind of Signal acquiring and processing apparatus and method for photoacoustic imaging.The device includes：Ultrasonic detector, for receiving the photoacoustic signal of the opening position from destination organization different depth, and photoacoustic signal is converted into electric signal；Compensation circuit, for carrying out variable signal compensation to electric signal according to analog control signal；Analog-to-digital conversion module, for carrying out analog-to-digital conversion to electric signal, to generate data signal；Field programmable gate array, for receiving data signal, row format is entered to data signal and changes and is sent to host computer for rebuilding photoacoustic image；And for receiving offset voltage information and generating digital controlled signal according to offset voltage information；D/A converting circuit, for digital controlled signal to be carried out into digital-to-analogue conversion, to generate above-mentioned analog control signal.The above-mentioned Signal acquiring and processing apparatus and method scalability for photoacoustic imaging is strong, and can obtain the more reliable photoacoustic image of quality.
Description
Technical field
The present invention relates to computer aided medicine technical field, in particular it relates to which a kind of signal for photoacoustic imaging is adopted
Collection and processing unit and method.
Background technology
With the development of science and technology, in industrial production and scientific research, it is often necessary to high accuracy, the letter of high-speed
Number signal acquisition, processing and analysis are carried out, therefore higher requirement is proposed to Signal sampling and processing device.
Conventional Medical Imaging Technology has ultrasonic imaging, optical imagery, x-ray imaging and Magnetic resonance imaging (MRI) etc..
These imaging techniques are imaged according to the characteristic variations in a certain respect in biological tissue, and have certain limitation.
Ultrasonic imaging penetration depth can reach centimetres, but for early lesion tissue (such as：Cancer), its group
It is not it is obvious that ultrasonic imaging can not reach very high image contrast, therefore for early lesion tissue to knit lesion
Examination has certain difficulty.
The development of optical imagery substantially increases the contrast of medical image.But as light penetrates the increasing of tissue depth
Add, the strong scattering of light in the tissue causes imaging space resolution ratio to decline rapidly, therefore is difficult to apply to profound tissue
Medical imaging is studied and the early diagnosis of disease.
Photoacoustic imaging (Photoacoustic Imaging) technology based on optoacoustic effect is that the one kind occurred in recent years is new
The lossless Biologic Medical Image technology of type, believed by carrying out image reconstruction to the photoacoustic signal collected to obtain the inside of tissue
Breath.The technology combines the advantages of optical imagery and ultrasonic imaging.
In photoacoustic imaging technology, when short pulse electromagnetic wave is irradiated in tissue, biological tissue by electromagnetic wave irradiation so as to
The small temperature rise of heat moment generation is absorbed, causes thermal expansion effects to inspire the photoacoustic signal for belonging to ultrasonic wave range.Swashed
The photoacoustic signal of hair carries the information of illuminated tissue electromaganic wave absorbing property and by organizing outwards to propagate.Pass through collection group
The photoacoustic signal of surrounding is knitted, the figure of organization internal electro-magnetic wave absorption distribution can be reconstructed using corresponding image reconstruction algorithm
Picture.And do not have organized flex effect then for non-electro-magnetic wave absorption region, photoacoustic signal is not produced, can thus avoid swashing
Influence of the luminous disperse to imaging resolution.
On the one hand, the Signal acquiring and processing device of existing photoacoustic imaging is most by the way of being combined with CPU, if
Integralization photoacoustic imaging system is counted, although integrated level is high, operability is not strong, at specific algorithm improvement and data
Reason can only rely on operating system to carry out, and function is weaker in terms of operating system exploitation, and the implementation process of technical scheme is limited.Separately
On the one hand, the data signal generated according to the Signal acquiring and processing device for being currently used for photoacoustic imaging carries out photoacoustic imaging,
It is larger by imaging section position influence, it is difficult to obtain the photoacoustic image of reliable in quality.
Accordingly, it is desirable to provide a kind of Signal acquiring and processing apparatus and method for photoacoustic imaging, with least in part
Solves the above-mentioned problems in the prior art.
The content of the invention
In order to solve problems of the prior art at least in part, according to an aspect of the present invention, there is provided a kind of
For the Signal acquiring and processing device of photoacoustic imaging, including：
Ultrasonic detector, for receiving the photoacoustic signal of the opening position from destination organization different depth, and by the light
Acoustical signal is converted into electric signal；
Compensation circuit, for carrying out variable signal compensation to the electric signal according to analog control signal；
Modulus (A/D) modular converter, for carrying out analog-to-digital conversion to compensated electric signal, to generate data signal；
Field programmable gate array (FPGA), for receiving the data signal, row format is entered to the data signal and is turned
Change and be sent to host computer and be used to rebuild photoacoustic image；And for receiving offset voltage information and being believed according to the offset voltage
Breath generation digital controlled signal, wherein the offset voltage information is included on the position for the destination organization different depth
The information of the offset voltage numerical value at place；
Digital-to-analogue (D/A) change-over circuit, for the digital controlled signal to be carried out into digital-to-analogue conversion, controlled with generating the simulation
Signal processed.
Schematically, the compensation circuit includes the first variable signal compensation sub-circuit of cascade and the second variable gain is mended
Sub-circuit is repaid, wherein, the first variable signal compensation sub-circuit is used to the electric signal be fixed gain amplification, described
Analog control signal only inputs the second variable signal compensation sub-circuit, and the second variable signal compensation sub-circuit is used for root
Variable signal compensation is carried out to the electric signal according to analog control signal.
Schematically, the FPGA includes Clock management module, for providing system clock for described device；
The analog-to-digital conversion module includes clock from frequency multiplication chip, during for by system from the Clock management module
Clock carries out frequency multiplication, and the clock through frequency multiplication is sent into the FPGA, to receive the data signal as the control FPGA
Clock.
Schematically, described device also includes：The amplifying circuit of the ultrasonic detector is connected, for the electric signal
It is amplified.
Schematically, the amplifying circuit includes the low noise amplification chip of two cascades.
Schematically, described device also includes the filtering being connected between the compensation circuit and the analog-to-digital conversion module
Circuit, for carrying out LPF to the electric signal.
Schematically, the compensation circuit, the amplifying circuit and the filter circuit are integrated on same circuit board.
Schematically, the FPGA includes bandpass filter, for carrying out bandpass filtering to the data signal.
Schematically, the FPGA also includes random access memory, is connected to the analog-to-digital conversion module and the band
Between bandpass filter, for caching the data signal.
Schematically, the FPGA includes asynchronous FIFO (FIFO) memory and Ethernet interface interconnected,
The asynchronous FIFO memory is used to enter the data signal row format conversion, and the Ethernet interface is used to through form to turn
The data signal changed is sent to the host computer via Ethernet.
According to a further aspect of the invention, a kind of Signal acquiring and processing method for photoacoustic imaging is also provided, including：
The photoacoustic signal of the opening position from destination organization different depth is received, and the photoacoustic signal is converted into telecommunications
Number；
Receive offset voltage information and digital controlled signal is generated according to the offset voltage information, wherein the compensation electricity
Information is pressed to include the information of the offset voltage numerical value on the opening position for the destination organization different depth；
The digital controlled signal is subjected to digital-to-analogue conversion, to generate analog control signal；
Variable signal compensation is carried out to the electric signal according to the analog control signal；
Analog-to-digital conversion is carried out to compensated electric signal, to generate data signal；And
Enter row format to the data signal to change and be sent to host computer, for rebuilding photoacoustic image.
The above-mentioned Signal acquiring and processing apparatus and method for photoacoustic imaging, overall control is carried out using programmable gate array
System, flexibly and easily, scalability is strong, is easy to system maintenance and upgrading；In addition, characteristic of the above-mentioned technical proposal based on photoacoustic imaging
Photoacoustic signal is handled, the more reliable photoacoustic image of quality can be obtained.
A series of concept of simplification is introduced in the content of the invention, these concepts will enter one in specific embodiment part
Step describes in detail.Present invention part be not meant to attempt the key feature for limiting technical scheme claimed and
Essential features, the protection domain for attempting to determine technical scheme claimed is not meant that more.
Below in conjunction with accompanying drawing, advantages and features of the invention are described in detail.
Brief description of the drawings
The drawings below of the present invention is used to understand the present invention in this as the part of the present invention.Shown in the drawings of this hair
Bright embodiment and its description, for explaining the principle of the present invention.In the accompanying drawings,
Fig. 1 shows the schematic of the Signal acquiring and processing device according to an embodiment of the invention for photoacoustic imaging
Block diagram；
Fig. 2 shows the signal of signal intensity according to an embodiment of the invention and compensation with the change in depth of destination organization
Figure；And
The schematic frame of Fig. 3 Signal acquiring and processing devices in accordance with another embodiment of the present invention for photoacoustic imaging
Figure.
Embodiment
In the following description, there is provided substantial amounts of details is so as to thoroughly understand the present invention.However, this area skill
Art personnel will be seen that, described below to only relate to presently preferred embodiments of the present invention, and the present invention can be without one or more so
Details and be carried out.In addition, in order to avoid obscuring with the present invention, for some technical characteristics well known in the art not
It is described.
Signal acquiring and processing device for photoacoustic imaging provided herein is using FPGA controls compensation circuit, mould
Number modular converter and data transfer, realize the collection and processing of signal.
According to an aspect of the present invention, there is provided a kind of Signal acquiring and processing device for photoacoustic imaging.Fig. 1 is shown
The schematic block diagram of Signal acquiring and processing device 100 according to an embodiment of the invention for photoacoustic imaging.Such as Fig. 1 institutes
Show, device 100 includes ultrasonic detector, compensation circuit, analog-to-digital conversion module, FPGA and D/A converter module.
Short-pulse laser is produced by pulse laser.Then, the laser is homogenized by convex lens and frosted glass plate etc.
Afterwards, it is irradiated in destination organization to be measured.Destination organization absorbs energy expansion and produces photoacoustic signal.Based on default depth interval,
Ultrasonic detector is used for the photoacoustic signal for receiving the opening position from destination organization different depth, and the photoacoustic signal is converted into
Electric signal.It is appreciated that the time delay that photoacoustic signal caused by the opening position of destination organization different depth enters pulse laser is
Different, deeper positions, its time delay are longer.In other words, in the photoacoustic signal that ultrasonic detector is received, more early reception
Partly belong to the more shallow position of destination organization；The deeper position for partly belonging to destination organization of more late reception.
Photoacoustic signal is from during destination organization is transferred to ultrasonic detector, producing declining for approximate exponential form
Subtract.This make it that the signal intensity that the photoacoustic signal of the opening position from destination organization different depth reaches ultrasonic detector is to differ
Cause.The photoacoustic signal of deeper position from destination organization, the intensity for reaching ultrasonic detector are smaller.So, rebuilding
Image in occur that the depth of destination organization is deeper, its image is fuzzyyer.This has had a strong impact on the quality of image.According to
One embodiment of the application, variable signal compensation is carried out to the electric signal of ultrasonic detector output.Fig. 2 is shown according to this hair
The signal intensity of bright one embodiment and the schematic diagram for compensating the change in depth with destination organization.In fig. 2, transverse axis represents target
Depth in tissue where diverse location, the longitudinal axis represent the intensity level of photoacoustic signal or the amplitude of offset voltage.Virgin curve table
Show that destination organization sends photoacoustic signal, its intensity level is as the depth of destination organization increases and significantly decays.Compensated curve represents
The amplitude of offset voltage is as the depth of destination organization increases and accordingly increases.
According to one embodiment of the invention, in the device 100, FPGA is used to receive offset voltage information and according to the compensation
Information of voltage generates digital controlled signal.Wherein the offset voltage information is included on the position for destination organization different depth
The information of the offset voltage numerical value at place.The digital controlled signal that D/A converting circuit is used to be exported FPGA carries out digital-to-analogue and turned
Change, to generate corresponding analog control signal, to input into compensation circuit.Compensation circuit is used for according to analog control signal pair
The electric signal converted by photoacoustic signal carries out variable signal compensation.Hereby it is achieved that a backfeed loop, is completed to optoacoustic
The compensation of decay in signals transmission.
The position for the different depth that destination organization can be directed to determines different offset voltage numerical value.Based on the offset voltage
Numerical value can determine the offset voltage information that FPGA is received.
According to one embodiment of the invention, according to attenuation characteristic of the photoacoustic signal in water, attenuation coefficient a can be 0.4-
0.7dB/(MHz*cm).The frequency of the photoacoustic signal sent according to destination organization, it is determined that the position for destination organization different depth
Put the gain values (dB) that sent photoacoustic signal compensates.For example, the frequency for the photoacoustic signal that destination organization is sent is
10MHz, for the opening position that destination organization depth is h, the gain values that the photoacoustic signal sent to the position compensates
For 10*h*a (dB).Assuming that being based on default depth interval, the position of 100 different depths is determined on the target tissue.Then
For the destination organization, a gain sequence for including 100 elements can be obtained, each element therein is to be directed to target group
The gain values that the position for the unique corresponding depth knitted compensates.Further according to the variable signal compensation chip institute in compensation circuit
Intrinsic voltage and the relation of gain values, it is determined that offset voltage numerical value corresponding with each gain values.Thus, one is obtained
Include the offset voltage sequence of 100 offset voltage numerical value.
Reference voltage based on the offset voltage sequence and D/A converter module, it may be determined that FPGA to be entered compensation electricity
Press information.For example, it is assumed that D/A converter module includes the digital analog converter of 8 bits, its reference voltage is 5V, then resolution ratio
For 5/2^8=19.53mV；Assume that an offset voltage numerical value in offset voltage sequence is 19.53mv again；So, the compensation
Data signal corresponding to voltage value is 00000001.If offset voltage numerical value is 19.53*3, then the offset voltage numerical value
Corresponding data signal is 00000011, by that analogy.
Thus, offset voltage information includes the offset voltage numerical value on the opening position for destination organization different depth
Information.It is appreciated that the offset voltage information is the form of data signal.FPGA can receive above-mentioned offset voltage information,
And digital controlled signal is generated according to the offset voltage information.
In one example, read-only storage (ROM) is may include in FPGA.Above-mentioned offset voltage information can be write should
ROM.FPGA reads the data in ROM.In one example, digital-to-analogue conversion is transferred to from ROM in the form of 8 bit parallel datas
Module.D/A converter module is used to digital controlled signal being converted to corresponding analog control signal.By the analog control signal
The gain control pin of the variable signal compensation chip of compensation circuit is applied to, so that compensation circuit produces accordingly to electric signal
Gain compensation.
Also include analog-to-digital conversion module in device 100, it is connected between compensation circuit and FPGA, for compensated
Electric signal carries out analog-to-digital conversion, to generate data signal.Exemplarily, the signal of analog-to-digital conversion module output is low voltage difference
Signal (LVDS), this is a serial signal.
FPGA is additionally operable to receive the data signal from analog-to-digital conversion module, and row format is entered to the data signal and changes and sends
To host computer, for rebuilding photoacoustic image.The host computer can be the computing devices such as personal computer or server.FPGA is based on
SPI protocol receives LVDS signals from analog-to-digital conversion module, and can convert thereof into parallel signal and be handled.FPGA possesses
Powerful IP kernel, serial LVDS signals can be converted into parallel signal.FPGA may include coffret, such as Ethernet
Interface and USB interface etc..Coffret typically only support corresponding to Data Transport Protocol.FPGA enters received digital signal
Row format is changed, and host computer is sent to based on specific Data Transport Protocol in order to be transmitted over interface.Host computer can be with
Data Transport Protocol and corresponding network address parameter have been configured, data signal is received from FPGA.
It may include Clock management module in FPGA, for providing system clock for device 100.FPGA can pass through its difference
The clock provided for compensation circuit and analog-to-digital conversion module, to control the compensation electricity for the opening position of destination organization different depth
Numerical applications are pressed to corresponding data signal.
The above-mentioned Signal acquiring and processing device for photoacoustic imaging according to embodiments of the present invention is carried out total using FPGA
Body controls, and flexibly and easily, scalability is strong, is easy to system maintenance and upgrading.In addition, carrying out feedback compensation to photoacoustic signal, protect
The photoacoustic signal of destination organization depths and the photoacoustic signal of target tissue surface have been demonstrate,proved in photoacoustic imaging as intensity approximation, from
And negative effect of decay of the photoacoustic signal in transmitting procedure to photoacoustic imaging is avoided, significantly improve the matter of photoacoustic image
Amount.
As it was previously stated, FPGA may include Clock management module, for providing system clock for device.For example, FPGA is to mould
Number modular converter provides a clock signal, for controlling the analog-to-digital conversion of analog-to-digital conversion module to operate.According to of the invention one
Embodiment, analog-to-digital conversion module include clock from frequency multiplication chip.Alternatively, the clock is low noise, stablized from frequency multiplication chip.Should
Clock is used to the system clock from Clock management module is carried out into frequency multiplication automatically from frequency multiplication chip, and the clock through frequency multiplication is sent out
FPGA is given, the clock to receive data signal as control FPGA from analog-to-digital conversion module.So, analog-to-digital conversion module can be with
Using parallel time alternating sampling technology, sample rate is improved, and then improve the definition of photoacoustic image.For example, for ophthalmology
Photoacoustic signal, highest frequency can reach 20MHz.Said apparatus can realize under the frequency collection of photoacoustic signal with real time
Processing, and the data after processing are uploaded into host computer, this will make to carry out photoacoustic imaging for the more delicate area in destination organization
It is possibly realized.
Fig. 3 shows the Signal acquiring and processing device 300 according to another embodiment of the present invention for photoacoustic imaging.Dress
Put it is 300 similar with device 100, wherein also including ultrasonic detector, compensation circuit, analog-to-digital conversion module, FPGA and digital-to-analogue conversion
Module.For sake of simplicity, these parts are no longer described in detail at this.
As shown in figure 3, device 300 includes the amplifying circuit of connection ultrasonic detector.The amplifying circuit is used to visit ultrasound
The electric signal that device is converted is surveyed to be amplified.Because photoacoustic signal is very weak in itself, usually μ V magnitudes, therefore ultrasonic detector is defeated
The electric signal gone out is also very faint.Carrying out pre-amplification to the electric signal first can ensure that later process signal is undistorted.It is optional
Ground, the amplifying circuit, such as OPA847 chips are realized using low noise amplification chip.
Alternatively, the amplifying circuit includes the low noise amplification chip of two cascades, forms the direct-coupled LNA of two-stage
Big circuit.Exemplarily, the gain of the amplifying circuit can be 52dB, and bandwidth is up to 100MHz.Thus, after avoiding to essence
Distorted signals problem in continuous processing.
Alternatively, first fixed gain compensation sub-circuit and second of the compensation circuit in device 300 including cascade are variable
Gain compensation sub-circuit.Wherein, the analog control signal from FPGA is only input to the second variable signal compensation sub-circuit, so that
It carries out variable signal compensation according to the analog control signal to electric signal.And the first fixed gain compensation sub-circuit is only used for pair
Electric signal is amplified.
When photoacoustic signal is very faint, the multiplication factor of amplifying circuit is probably inadequate.First fixed gain compensates
Sub-circuit performs fixed gain amplifieroperation to the electric signal that is received, and the second variable signal compensation sub-circuit is to the electricity that is received
Signal performs variable signal compensation operation.In one example, it is necessary to the dynamic compensation range of 0~2A (dB) intensity, but one
Individual variable signal compensation sub-circuit only has the dynamic compensation range of 0~1.5A (dB) intensity.Therefore by two variable signal compensations
Sub-circuit is cascaded, to realize the dynamic compensation range of 0~3A (dB) intensity.Two variable signal compensation sub-circuits carry out level
The mode of connection can further expand the intensity of electric signal as needed, ensure the quality of photoelectric image.
As shown in figure 3, device 300 can also include filter circuit, the filter circuit can be connected to compensation circuit and mould
Between number modular converter, for carrying out LPF to electric signal.By the electric signal that compensation circuit is exported is analog signal,
Before it inputs analog-to-digital conversion module, high-frequency noise may be contained in the analog signal.If the analog signal directly inputs
Analog-to-digital conversion module, spectral aliasing may be caused, cause sampling to fail.Alternatively, the filter circuit includes low pass filter.Light
Acoustical signal highest frequency is up to 20MHz, therefore the cut-off frequency of the low pass filter can be set to 20MHz.Alternatively, the low pass
Wave filter is active low-pass filter.Compared to passive filter, active filter does not have to inductance coil, thus in volume, weight
Measure, price, it is linear etc. that there is obvious superiority, it is easy to integrated.It is active this can be designed using LT6600-20 chips
Low pass filter, ensure in the range of gain -3dB, band connection frequency 20MHz.Because active low-pass filter input impedance is high,
Output impedance is low, and it can provide good isolation performance, and can provide required gain；Low-frequency cut-off frequency can be made to reach very
Low scope.In a word, the presence of wave filter can effectively prevent occurring aliasing in photoacoustic image.
Alternatively, in device 300, amplifying circuit, compensation circuit and filter circuit are integrated on same circuit board, jointly
Form front end analogue signal conditioning circuit.The circuit board can be drawn using shielding processing and windowing processing, and use multilayer
Circuit board arrangements.Thus, the signal to noise ratio of device 300 is can further improve, reduces signal distortion.Additionally it is possible to greatly improve
The convenience that later stage Function Extension or performance improve.
As shown in figure 3, FPGA includes bandpass filter, for carrying out band logical filter to FPGA received digital signals
Ripple.Frequency band range residing for photoacoustic signal is usually 200KHz~20MHz.In one example, bandpass filter is used to filter out
Low frequency signal less than 200KHz and the signal higher than 20MHz frequencies.It is appreciated that the center frequency of different ultrasonic detectors
Rate and bandwidth are different, and numerical value here can be set according to different ultrasonic detectors.It can utilize inside FPGA
Abundant logical resource and multiplier, logical resource and multiplier are laid out wiring, so as to realize FIR bands inside FPGA
Bandpass filter.Alternatively, the bandpass filter is 32 rank FIR bandpass filters.Bandpass filter has further filtered out noise, protects
The definition of photoacoustic image is demonstrate,proved.
Alternatively, random access memory (RAM) is also included in FPGA, is connected to analog-to-digital conversion module and bandpass filter
Between, for caching data signal.FPGA provides clock for RAM, and it is same clock that it, which reads and writes clock,.Alternatively, RAM is double
Mouth RAM.RAM is FPGA internal hardware structure.By corresponding IP kernel, the RAM of suitable bit wide and depth can be established, is passed through
Exampleization calling module can completes the caching of data.Level caches of the RAM as data, can be prevented due to analog-to-digital conversion mould
The conversion operation of block is too fast, and bandpass filter has little time to complete filtering and lose data.
FPGA includes the asynchronous FIFO memory and Ethernet interface interconnected.Asynchronous FIFO memory is used for numeral
Signal enters row format conversion.Ethernet interface is used to the data signal changed through form being sent to host computer via Ethernet.
Data signal is sent to host computer by FPGA Ethernet interface via gigabit Ethernet.The Ethernet interface is assisted using GMII
Discuss, i.e., it uses 125MHz clock speeds, 8bit bit wides to carry out signal transmission.Therefore, before transmitting, FPGA will be received
Data signal is converted to standard data (125MHz, 8bit bit wide), to be sent to host computer via Ethernet interface.Via
The data signal and the frequency and bit wide of FPGA received digital signals of Ethernet transmission differ.Asynchronous FIFO memory
Write-in data clock with read data clock it is different.Asynchronous FIFO memory is used to enter data signal row format conversion.Can
To preset the write-in data bit width of asynchronous FIFO memory, read data bit width and storage depth, then pass through different read-writes
Clock signal is controlled to asynchronous FIFO memory, it is possible to realizes and the form of data signal is changed, such as change wherein
The bit wide and speed of data, to meet the requirement of Ethernet transmission speed.The transmission speed of Ethernet can reach 900Mbit/
It s, can preferably meet the requirement of data transfer, ensure the quality of photoacoustic image.
According to a further aspect of the invention, a kind of Signal acquiring and processing method for photoacoustic imaging is additionally provided.The party
Method comprises the following steps.
S100, the photoacoustic signal of the opening position from destination organization different depth is received, and the photoacoustic signal is converted
For electric signal；
S200, receive offset voltage information and digital controlled signal is generated according to the offset voltage information, wherein described
Offset voltage information includes the information of the offset voltage numerical value on the opening position for the destination organization different depth；
S300, the digital controlled signal is subjected to digital-to-analogue conversion, to generate analog control signal；
S400, variable signal compensation is carried out to the electric signal according to the analog control signal；
S500, analog-to-digital conversion is carried out to compensated electric signal, to generate data signal；And
S600, row format is entered to the data signal and changes and is sent to host computer, for rebuilding photoacoustic image.
Schematically, before the step S200, methods described also includes：The electric signal is amplified.
Schematically, before the step S500, methods described also includes：Gain is fixed to the electric signal to put
Greatly.
Schematically, before the step S500, methods described also includes：LPF is carried out to the electric signal.
Schematically, before the step S600, methods described also includes：Band logical filter is carried out to the data signal
Ripple.
Schematically, before the bandpass filtering step, methods described also includes：Cache the data signal.
In the description above with respect to the Signal acquiring and processing device for photoacoustic imaging, it is described in detail wherein
The embodiment of each part and function etc., those skilled in the art combine above with respect to Fig. 1 to Fig. 3 description it will be appreciated that
Specific implementation and its advantage for each step in the Signal acquiring and processing method of photoacoustic imaging etc., for sake of simplicity, herein
Repeated not to this.
In the specification that this place provides, numerous specific details are set forth.It is to be appreciated, however, that the implementation of the present invention
Example can be put into practice in the case of these no details.In some instances, known structure and skill is not been shown in detail
Art, so as not to obscure the understanding of this description.
Similarly, it will be appreciated that in order to simplify the present invention and help to understand one or more of each inventive aspect,
To the present invention exemplary embodiment description in, each feature of the invention be grouped together into sometimes single embodiment, figure,
Or in descriptions thereof.However, the technical interpretation of the invention should not be intended into reflection is following：It is i.e. claimed
Application claims features more more than the feature being expressly recited in each claim.More precisely, such as corresponding power
As sharp claim reflects, its inventive point is the spy that can use all features less than some disclosed single embodiment
Levy to solve corresponding technical problem.Therefore, it then follows thus claims of embodiment are expressly incorporated in this specific
Embodiment, wherein each claim is in itself as separate embodiments of the invention.
It will be understood to those skilled in the art that in addition to mutually exclusive between feature, any combinations pair can be used
All features and so disclosed any method disclosed in this specification (including adjoint claim, summary and accompanying drawing)
Or all processes or unit of device are combined.Unless expressly stated otherwise, this specification (including adjoint right will
Ask, make a summary and accompanying drawing) disclosed in each feature can be replaced by the alternative features for providing identical, equivalent or similar purpose.
In addition, it will be appreciated by those of skill in the art that although some embodiments described herein include other embodiments
In included some features rather than further feature, but the combination of the feature of different embodiments means in of the invention
Within the scope of and form different embodiments.For example, in detail in the claims, embodiment claimed it is one of any
Mode it can use in any combination.
It should be noted that the present invention will be described rather than limits the invention for above-described embodiment, and ability
Field technique personnel can design alternative embodiment without departing from the scope of the appended claims.In the claims,
Any reference symbol between bracket should not be configured to limitations on claims.Word "comprising" does not exclude the presence of not
Element or step listed in the claims.Word "a" or "an" before element does not exclude the presence of multiple such
Element.The present invention can realize by means of including the hardware of some different elements.If weighed in the unit for listing equipment for drying
During profit requires, several in these devices can be embodied by same hardware branch.
The present invention is illustrated by above-described embodiment, but it is to be understood that, above-described embodiment is only intended to
Citing and the purpose of explanation, and be not intended to limit the invention in described scope of embodiments.In addition people in the art
Member can also make more kinds of it is understood that the invention is not limited in above-described embodiment according to the teachings of the present invention
Variants and modifications, these variants and modifications are all fallen within scope of the present invention.Protection scope of the present invention by
The appended claims and its equivalent scope are defined.
Claims (11)
1. a kind of Signal acquiring and processing device for photoacoustic imaging, including：
Ultrasonic detector, for receiving the photoacoustic signal of the opening position from destination organization different depth, and the optoacoustic is believed
Number it is converted into electric signal；
Compensation circuit, for carrying out variable signal compensation to the electric signal according to analog control signal；
Analog-to-digital conversion module, for carrying out analog-to-digital conversion to compensated electric signal, to generate data signal；
Field programmable gate array, for receiving the data signal, row format is entered to the data signal and changes and is sent to
Host computer is used to rebuild photoacoustic image；And for receiving offset voltage information and generating numeral according to the offset voltage information
Control signal, wherein the offset voltage information includes the compensation electricity on the opening position for the destination organization different depth
Press the information of numerical value；
D/A converting circuit, for the digital controlled signal to be carried out into digital-to-analogue conversion, to generate the analog control signal.
2. device as claimed in claim 1, it is characterised in that the compensation circuit includes the first variable signal compensation of cascade
Sub-circuit and the second variable signal compensation sub-circuit, wherein, the first variable signal compensation sub-circuit is used for the telecommunications
Number it is fixed gain amplification, the analog control signal only inputs the second variable signal compensation sub-circuit, and described second
Variable signal compensation sub-circuit is used to carry out variable signal compensation to the electric signal according to analog control signal.
3. device as claimed in claim 1, it is characterised in that
The field programmable gate array includes Clock management module, for providing system clock for described device；
The analog-to-digital conversion module includes clock from frequency multiplication chip, for the system clock from the Clock management module to be entered
Row frequency multiplication, and the clock through frequency multiplication is sent to the field programmable gate array, to be used as the control field programmable gate
The clock of data signal described in array received.
4. the device as described in any one of claims 1 to 3, it is characterised in that also include：
The amplifying circuit of the ultrasonic detector is connected, for being amplified to the electric signal.
5. device as claimed in claim 4, it is characterised in that the amplifying circuit includes the low noise amplification core of two cascades
Piece.
6. device as claimed in claim 4, it is characterised in that also include being connected to the compensation circuit and the analog-to-digital conversion
Filter circuit between module, for carrying out LPF to the electric signal.
7. device as claimed in claim 6, it is characterised in that the compensation circuit, the amplifying circuit and the filtered electrical
Road is integrated on same circuit board.
8. the device as described in any one of claims 1 to 3, it is characterised in that the field programmable gate array includes band logical
Wave filter, for carrying out bandpass filtering to the data signal.
9. device as claimed in claim 8, it is characterised in that the field programmable gate array also includes random access memory
Device, it is connected between the analog-to-digital conversion module and the bandpass filter, for caching the data signal.
10. the device as described in any one of claims 1 to 3, it is characterised in that the field programmable gate array includes mutual
The asynchronous first-in/first-out memory and Ethernet interface of connection, the asynchronous first-in/first-out memory are used for the data signal
Enter row format conversion, the Ethernet interface is described upper for will be sent to through the data signal that form is changed via Ethernet
Machine.
11. a kind of Signal acquiring and processing method for photoacoustic imaging, including：
The photoacoustic signal of the opening position from destination organization different depth is received, and the photoacoustic signal is converted into electric signal；
Receive offset voltage information and digital controlled signal is generated according to the offset voltage information, wherein the offset voltage is believed
Breath includes the information of the offset voltage numerical value on the opening position for the destination organization different depth；
The digital controlled signal is subjected to digital-to-analogue conversion, to generate analog control signal；
Variable signal compensation is carried out to the electric signal according to the analog control signal；
Analog-to-digital conversion is carried out to compensated electric signal, to generate data signal；And
Enter row format to the data signal to change and be sent to host computer, for rebuilding photoacoustic image.
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