CN107736618A - 一种具有抗疲劳功效的丸剂及其制备方法和应用 - Google Patents
一种具有抗疲劳功效的丸剂及其制备方法和应用 Download PDFInfo
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Abstract
本发明公开了一种具有抗疲劳功效的丸剂,它由如下重量份数的原料制备得到:鲜芦根15‑35份、藿香10‑30份、荷叶15‑25份、麦芽10‑20份、栀子10‑20份和桔梗10‑20份,还公开了制备方法及其在制备具有抗疲劳功效药物中的应用。
Description
技术领域
本发明涉及保健食品技术领域,具体涉及一种具有抗疲劳功效的丸剂及其制备方法和应用。
背景技术
疲劳是一种主观不适感觉,但客观上会在同等条件下,失去其完成原来所从事的正常活动或工作能力。主要原因是生理上的变化:由于乳酸及其他代谢产物的堆积,肌肉张力下降,运动耐久性降低;由于二氧化碳的堆积,刺激呼吸中枢,还会导致打哈欠。凡是疾病发展到一定阶段都可出现疲乏,故可以引起疲乏的疾病很多。迄今为止,人们正在寻找一种制作简单、服用方便的抗疲劳的中药。
发明内容
发明目的:为了解决上述问题,本发明的目的在于提供一种具有抗疲劳功效的丸剂及其制备方法和应用。
技术方案:本发明的目的是通过如下的方案实现的:
一种具有抗疲劳功效的丸剂,它由如下重量份数的原料制备得到:鲜芦根15-35份、藿香10-30份、荷叶15-25份、麦芽10-20份、栀子10-20份和桔梗10-20份。
所述具有抗疲劳功效的丸剂,它由如下重量份数的原料制备得到:鲜芦根25份、藿香20份、荷叶20份、麦芽15份、栀子15份和桔梗15份。
所述具有抗疲劳功效的丸剂,制备方法包括如下步骤:取已粉碎的藿香采用水蒸气蒸馏法提取3小时,得总挥发油,按照重量比1∶10,用β-环糊精包合,100KDa超滤膜超滤,得挥发油β环糊精溶液,取其他中药与藿香提取挥发油后的药渣混合,加10倍量水回流提取2次,每次1小时,合并提取液,0.45μm微孔滤膜过滤,滤液与藿香挥发油β-环糊精溶液合并,采用截留分子量300~500Da纳滤膜浓缩,浓缩液减压干燥,粉碎,添加辅料制备成丸剂。
所述具有抗疲劳功效的丸剂在制备具有抗疲劳功效保健食品中的应用。。
有益效果:中医理论认为,本方中鲜芦根清热生津、除烦、止呕、利尿,藿香芳香化浊,和中止呕,发表解暑为君药,荷叶清心解暑、散瘀止血、消风祛湿,麦芽行气消食,健脾开胃,回乳消胀为臣药,栀子清热,泻火,凉血、桔梗宣肺,利咽,祛痰,排脓为佐使药,诸药相合,用于缓解体力疲劳。本发明组成为中药材,无毒副作用,价格便宜。
具体实施方式
以下通过实施例形式,对本发明的上述内容再作进一步的详细说明,但不应将此理解为本发明上述主题的范围仅限于以下的实例,凡基于本发明上述内容所实现的技术均属于本发明的范围。
实施例1:取鲜芦根15份、藿香30份、荷叶15份、麦芽20份、栀子10份和桔梗20份,制备方法包括如下步骤:取已粉碎的藿香采用水蒸气蒸馏法提取3小时,得总挥发油,按照重量比1∶10,用β-环糊精包合,100KDa超滤膜超滤,得挥发油β环糊精溶液,取其他中药与藿香提取挥发油后的药渣混合,加10倍量水回流提取2次,每次1小时,合并提取液,0.45μm微孔滤膜过滤,滤液与藿香挥发油β-环糊精溶液合并,采用截留分子量300~500Da纳滤膜浓缩,浓缩液减压干燥,粉碎,添加辅料制备成丸剂。
实施例2:取鲜芦根35份、藿香10份、荷叶25份、麦芽10份、栀子20份和桔梗10份,制备方法包括如下步骤:取已粉碎的藿香采用水蒸气蒸馏法提取3小时,得总挥发油,按照重量比1∶10,用β-环糊精包合,100KDa超滤膜超滤,得挥发油β环糊精溶液,取其他中药与藿香提取挥发油后的药渣混合,加10倍量水回流提取2次,每次1小时,合并提取液,0.45μm微孔滤膜过滤,滤液与藿香挥发油β-环糊精溶液合并,采用截留分子量300~500Da纳滤膜浓缩,浓缩液减压干燥,粉碎,添加辅料制备成丸剂。
实施例3:取鲜芦根25份、藿香20份、荷叶20份、麦芽15份、栀子15份和桔梗15份,制备方法包括如下步骤:取已粉碎的藿香采用水蒸气蒸馏法提取3小时,得总挥发油,按照重量比1∶10,用β-环糊精包合,100KDa超滤膜超滤,得挥发油β环糊精溶液,取其他中药与藿香提取挥发油后的药渣混合,加10倍量水回流提取2次,每次1小时,合并提取液,0.45μm微孔滤膜过滤,滤液与藿香挥发油β-环糊精溶液合并,采用截留分子量300~500Da纳滤膜浓缩,浓缩液减压干燥,粉碎,添加辅料制备成丸剂。
实施例4:本发明抗疲劳的药效学研究
实验动物:昆明种小鼠,雄性,体重18-22g,上海斯莱克实验动物有限公司提供,生产许可证:SCXK(沪)2007-0005。
实验药物:按上述实施例3的制备方法制备丸剂。
给药剂量:每日每只20g小鼠灌胃的口服液含生药量分别为0.4g,0.8g,1.2g,则按小鼠体重计,低剂量、中剂量和高剂量分别为20g生药量/kg、40g生药量/kg和80g生药量/kg。
阳性药精方堂牌养和胶囊,上海精方堂生物科技有限公司,国食健字G20050641,批号:20160523。规格:每粒装0.5g。病人使用一般每次2粒,每日2次,即人日用量2g,相当于每只20g小鼠用量为2*0.0026=0.0052g,按每公斤小鼠算,即阳性药组给予精方堂牌养和胶囊0.26g/kg。
实验过程:选健康小鼠50只,随机分出10只作为正常组,其余40只小鼠,随机分成4组:高剂量组、中剂量组、低剂量组、阳性药精方堂牌养和胶囊组,其中3个剂量组、精方堂牌养和胶囊组按上述剂量灌胃给药,正常组给0.2ml的水,每天上午1次,连续30d,进行小鼠负重游泳试验,小鼠尾部负小鼠体重5%的铅皮,放入水温为25℃,水深35cm的游泳箱中,用秒表记录自游泳至力竭死亡的时间,各组数据以均值±标准差表示,组间进行t测验。结果见表。
本发明对小鼠负重游泳试验的影响(n=10)
注:同正常组相比*p<0.05**<0.01
结论:本发明与正常组比较,明显延长小鼠负重游泳时间,说明本发明具有抗疲劳作用,与阳性药比较,时间延长,说明本发明抗疲劳效果优于阳性药。
Claims (4)
1.一种具有抗疲劳功效的丸剂,其特征在于,它由如下重量份数的原料制备得到:鲜芦根15-35份、藿香10-30份、荷叶15-25份、麦芽10-20份、栀子10-20份和桔梗10-20份。
2.如权利要求1所述一种具有抗疲劳功效的丸剂,其特征在于,它由如下重量份数的原料制备得到:鲜芦根25份、藿香20份、荷叶20份、麦芽15份、栀子15份和桔梗15份。
3.如权利要求1所述具有抗疲劳功效的丸剂,其特征在于,制备方法包括如下步骤:取已粉碎的藿香采用水蒸气蒸馏法提取3小时,得总挥发油,按照重量比1∶10,用β-环糊精包合,100KDa超滤膜超滤,得挥发油β环糊精溶液,取其他中药与藿香提取挥发油后的药渣混合,加10倍量水回流提取2次,每次1小时,合并提取液,0.45μm微孔滤膜过滤,滤液与藿香挥发油β-环糊精溶液合并,采用截留分子量300~500Da纳滤膜浓缩,浓缩液减压干燥,粉碎,添加辅料制备成丸剂。
4.如权利要求1或2所述具有抗疲劳功效的丸剂在制备具有抗疲劳功效保健食品中的应用。
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