CN106726008B - A kind of valve and preparation method thereof - Google Patents
A kind of valve and preparation method thereof Download PDFInfo
- Publication number
- CN106726008B CN106726008B CN201710005019.9A CN201710005019A CN106726008B CN 106726008 B CN106726008 B CN 106726008B CN 201710005019 A CN201710005019 A CN 201710005019A CN 106726008 B CN106726008 B CN 106726008B
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- valve
- polyurethane
- support portion
- finished product
- bracket
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2409—Support rings therefor, e.g. for connecting valves to tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
- A61F2/2415—Manufacturing methods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2442—Annuloplasty rings or inserts for correcting the valve shape; Implants for improving the function of a native heart valve
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C41/00—Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor
- B29C41/02—Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor for making articles of definite length, i.e. discrete articles
- B29C41/14—Dipping a core
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C41/00—Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor
- B29C41/02—Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor for making articles of definite length, i.e. discrete articles
- B29C41/20—Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor for making articles of definite length, i.e. discrete articles incorporating preformed parts or layers, e.g. moulding inserts or for coating articles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/20—Materials or treatment for tissue regeneration for reconstruction of the heart, e.g. heart valves
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Mechanical Engineering (AREA)
- Chemical & Material Sciences (AREA)
- Manufacturing & Machinery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Prostheses (AREA)
Abstract
The present invention provides a kind of valves and preparation method thereof, including, bracket and leaflet；The bracket is set to the valve as prepared by this method in the flexible leaflet and is formed by Best-Effort request coating method dip coating, so that leaflet and bracket are integrally formed, with higher service life, it is good that bracket itself does not contact antithrombotic effect directly with blood, valve can be obtained opening area in the production process, guarantee sufficient opening area and reduces the disqualification rate of finished product, having production technology simultaneously, step is simple compared with the existing technology, controllability is stronger, conducive to the batch production of valve.
Description
Technical field
The present invention relates to heart valve fields, more particularly to a kind of valve and preparation method thereof.
Background technique
The artificial valve of clinical use has two major classes at present, first is that mechanical prosthetic valve, main to be made by pyrolytic carbon.With St-
Jude Medical and Carbomedics mechanical prosthetic valve is representative.Its main feature is that long service life, but its leaflet is rigid leaflet sheet
Structure, leaflet folding sound is larger, because of blood compatibility reason, needs lifelong Anticoagulation of Warfarin, thrombosis and bleeding
Risk seriously affects therapeutic effect and patients ' life quality.Second is that biovalve, using valve made of cattle pericardium and porcine aortic valve as representative.
It is good with haemodynamics, it is not required to long-term anticoagulant advantage, but its calcification in vivo, decay, keeps its service life shorter, it is more
Number is adapted only to gerontal patient.
Summary of the invention
In view of the above drawbacks of the prior art and problem, the purpose of the embodiment of the present invention is that provide a kind of long service life and
The good valve of antithrombotic effect.
In order to achieve the above object, the invention provides the following technical scheme: a kind of valve preparation method, including, it is following to walk
It is rapid:
S1: cylindrical die is soaked in polyurethane solutions, using Best-Effort request coating method on cylindrical die surface
Prepare polyurethane inner membrance；
S2: taking valve bracket, and the outer surface that valve bracket is set in polyurethane inner membrance is obtained prefabricated valve semi-finished product, will
Prefabricated valve semi-finished product are soaked in polyurethane solutions, are coated and are gathered in prefabricated valve surface of semi-finished using Best-Effort request coating method
Urethane outer membrane；Demoulding, obtains prefabricated valve；
S3: moulding is arranged to prefabricated valve, obtains valve finished product.
Wherein, the step S3 includes:
S301: prefabricated valve includes support portion and polyurethane film portion, by the extra polyurethane film at the outlet end of support portion
Excision, the polyurethane film at support portion liquid inlet is inwardly overturn, and is stretched out from the outlet end of support portion, extending area forms annular
Open leaflet；
S302: the circumference trisection point of ring-shape open leaflet end is fixed on support portion by the stickup of 5%THF solution
Outlet end makes it be consistent with human heart valve closed state shape, obtains valve semi-finished product；
S303: valve semi-finished product are placed in 80-90 DEG C of drying box, keep the temperature 8-12 hours, obtain valve finished product.
Wherein, the step S2 includes:
Step using Best-Effort request coating method prefabricated valve surface of semi-finished coat polyurethane outer membrane after, further include as
Lower step:
S201: taking reinforcing rib, and reinforcing rib is pasted on support portion by binder, uses Best-Effort request coating method support portion
Surface forms reinforcing rib polyurethane outer membrane.
Wherein, the polyurethane solutions mass concentration is 5-30%.
Wherein, the polyurethane solutions the preparation method comprises the following steps: by PU grain dissolution into THF solution, stir evenly, and quiet
Set 1-2h.
Wherein, the material of the bracket is selected as stainless steel.
A kind of valve, including the poly- ammonia including annular frame support portion and leaflet portion obtained by tubular polyurethane film moulding
Ester valve further includes ring support, and the ring support is embedded in the annular frame support portion of the polyurethane valve.
Wherein, the tubular polyurethane film is coated on the ring support surface, from the liquid inlet of the ring support to
Outer extension；The extension of tubular polyurethane film is to overturning inside the ring support, extreme circumferential trisection point and the annular
The outlet end of bracket is fixedly connected.
Wherein, reinforcing rib is arranged in the ring support surface.
Wherein, the ring support surface is smooth mirror surface.
The valve as prepared by this method, so that leaflet and bracket are integrally formed, has higher by impregnating lifting molding
Service life, bracket is not good with contacting blood antithrombotic effect, and valve can be obtained opening area in the production process, guarantee
Sufficient opening area and the disqualification rate for reducing finished product, while there is production technology step is simple compared with the existing technology, it can
Control property is stronger, conducive to the batch production of valve.
Detailed description of the invention
In order to more clearly explain the embodiment of the invention or the technical proposal in the existing technology, to embodiment or will show below
There is attached drawing needed in technical description to be briefly described, it should be apparent that, the accompanying drawings in the following description is only this
Some embodiments of invention without any creative labor, may be used also for those of ordinary skill in the art
To obtain other drawings based on these drawings.
Fig. 1 is perspective view of the invention；
Fig. 2 is top view of the invention.
Specific embodiment
Below in conjunction with the embodiment of the present invention, technical solution of the present invention is clearly and completely described, it is clear that
Described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.Based on the implementation in the present invention
Example, every other embodiment obtained by those of ordinary skill in the art without making creative efforts belong to
The scope of protection of the invention.
As embodiment, a kind of valve preparation method takes cylindrical die, and the diameter of cylindrical die is less than valve bracket
Diameter, diameter are selected as 10-30mm, range needed for covering is clinical.The material of cylindrical die is preferably stainless steel, and surface polishing is extremely
Mirror surface, seamless and corner angle.Using Best-Effort request coating method, cylindrical die is soaked in polyurethane solutions, impregnates 10 points
Clock, by cylindrical die with 2.5 × 10-3M/s is at the uniform velocity lifted, to prepare polyurethane inner membrance on cylindrical die surface.Wherein,
The mass concentration of polyurethane solutions be 5-30%, preferably 15%.Preparation method be by PU grain dissolution into THF solution,
It stirs evenly, and stands 1-2h.Preferably, PU grain dissolution is stirred evenly into THF solution, stands 1.5 hours.Take valve
Membrane support, valve bracket are ring support, and the both ends of valve bracket are respectively the liquid inlet entered for blood stream and go out for blood stream
Outlet end, valve bracket is set in film outer surface in polyurethane, the polyurethane inner membrance outside the liquid inlet of valve bracket
Length is longer than the length of valve bracket.Prefabricated valve semi-finished product are obtained after the completion of suit.It, will be prefabricated using Best-Effort request coating method
Valve semi-finished product are soaked in polyurethane solutions, are impregnated 5 minutes, by cylindrical die with 2.5 × 10-3M/s is at the uniform velocity lifted, thus
Polyurethane outer membrane is coated in prefabricated valve surface of semi-finished.In valve bracket is coated on by polyurethane outer membrane and polyurethane inner membrance,
Keep valve bracket not exposed, avoid directly contacting with blood, promotes antithrombotic property, prolong the service life.Polyurethane film and
Valve bracket from cylindrical die get under, demoulding, obtain prefabricated valve.Moulding is arranged to prefabricated valve, forms human heart valve
Film shape.To obtain valve finished product.
Arrange the specific steps of moulding are as follows:
Valve bracket position is support portion in prefabricated valve, remaining position is polyurethane film portion, by entering for support portion
Polyurethane film excision at liquid end, will avoid valve bracket is exposed during excision.By the polyurethane at support portion liquid inlet
Film is turned inside out to support portion, and is stretched out from the outlet end of support portion, and extending area is trimmed, and extending area is made to be higher than branch
The outlet end 10-30mm of support part.Extending area forms cyclic annular open leaflet, and the diameter of the open leaflet of ring-type is that theoretically valve is opened
Maximum gauge is put, the openings of sizes of valve can be measured in the process, substandard product is filtered out, reduces finished product not
Qualification rate, and valve orifice size can get and accurately measure.By the end of ring-shape open leaflet, circumference trisection point passes through
5%THF solution pastes the outlet end for being fixed on support portion, it is made to be consistent with human heart valve closed state shape, obtains valve
Semi-finished product.Valve semi-finished product are placed in 80-90 DEG C of drying box, preferably 80 DEG C, keep the temperature 8-12 hour, acquisition valve at
Product.
In one embodiment, prefabricated valve can also be reinforced by reinforcing rib, improve the service life of valve.Reinforcing side
Formula is to take reinforcing rib, and reinforcing rib is pasted on support portion by binder, and binder is selected as existing binder, preferably,
THF solution.The prefabricated valve for having reinforced reinforcing rib is soaked in polyurethane solutions using Best-Effort request coating method, in support portion
Surface forms reinforcing rib polyurethane outer membrane.
Leaflet thickness is determined by soaking time, number, can is 0.02mm to 2mm, be depended on different parts valve to leaflet
The requirement of across valve pressure, pliability, intensity.Valve sinus portion refers to the part between annular leaflet and bracket, made by the present invention
Leaflet pliability is high, open abundant, blood can sufficiently be squeezed out to sinus portion when open, blood is not easy to stop gathering in sinus portion, is not easy shape
At thrombus.
Preferably, the outlet end of ring support is crown-shaped.
According to Fig. 1-2, a kind of valve, as made by the above method, including what is obtained by tubular polyurethane film moulding
Polyurethane valve including annular frame support portion and leaflet portion, further includes ring support 2, and the ring support 2 is embedded in institute
It states in the annular frame support portion of polyurethane valve 1.Wherein, the tubular polyurethane film is coated on the ring support surface,
Extend outwardly from the liquid inlet of the ring support；The extension of tubular polyurethane film is to overturning inside the ring support, end
End circumference trisection point 3 is fixedly connected with the outlet end of the ring support.Wherein, the ring support surface setting is reinforced
Muscle.Wherein, the ring support surface is smooth mirror surface.
The above description is merely a specific embodiment, but scope of protection of the present invention is not limited thereto, any
Those familiar with the art in the technical scope disclosed by the present invention, can easily think of the change or the replacement, and should all contain
Lid is within protection scope of the present invention.Therefore, the protection scope of the present invention shall be subject to the protection scope of the claims.
Claims (5)
1. a kind of valve preparation method, which is characterized in that including following steps:
S1: cylindrical die is soaked in polyurethane solutions, is prepared using Best-Effort request coating method on cylindrical die surface
Polyurethane inner membrance；
S2: taking valve bracket, and the outer surface that valve bracket is set in polyurethane inner membrance is obtained prefabricated valve semi-finished product, will be prefabricated
Valve semi-finished product are soaked in polyurethane solutions, coat polyurethane in prefabricated valve surface of semi-finished using Best-Effort request coating method
Outer membrane；Demoulding, obtains prefabricated valve；
S3: moulding is arranged to prefabricated valve, obtains valve finished product；
The step S3 includes:
S301: prefabricated valve includes support portion and polyurethane film portion, and the extra polyurethane film at the outlet end of support portion is cut off,
Polyurethane film at support portion liquid inlet is inwardly overturn, is stretched out from the outlet end of support portion, extending area forms ring-shape open
Leaflet；
S302: the circumference trisection point of ring-shape open leaflet end is pasted to the liquid out for being fixed on support portion by 5%THF solution
End, makes it be consistent with human heart valve closed state shape, obtains valve semi-finished product；
S303: valve semi-finished product are placed in 80-90 DEG C of drying box, keep the temperature 8-12 hours, obtain valve finished product.
2. a kind of valve preparation method according to claim 1, which is characterized in that the step S2 includes:
It uses Best-Effort request coating method after prefabricated valve surface of semi-finished coats polyurethane outer membrane in step, further includes walking as follows
It is rapid:
S201: taking reinforcing rib, reinforcing rib is pasted on support portion by binder, using Best-Effort request coating method in support portion table
Face forms reinforcing rib polyurethane outer membrane.
3. a kind of valve preparation method according to claim 1, which is characterized in that the polyurethane solutions mass concentration is
5-30%.
4. a kind of valve preparation method according to claim 3, which is characterized in that the preparation method of the polyurethane solutions
Are as follows: it by PU grain dissolution into THF solution, stirs evenly, and stands 1-2h.
5. a kind of valve preparation method according to claim 1, which is characterized in that the material of the bracket is stainless steel.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710005019.9A CN106726008B (en) | 2017-01-04 | 2017-01-04 | A kind of valve and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710005019.9A CN106726008B (en) | 2017-01-04 | 2017-01-04 | A kind of valve and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106726008A CN106726008A (en) | 2017-05-31 |
| CN106726008B true CN106726008B (en) | 2019-01-22 |
Family
ID=58951018
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710005019.9A Active CN106726008B (en) | 2017-01-04 | 2017-01-04 | A kind of valve and preparation method thereof |
Country Status (1)
| Country | Link |
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| CN (1) | CN106726008B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107320218B (en) * | 2017-06-23 | 2019-08-16 | 武汉唯柯医疗科技有限公司 | Pulmonary artery intervenes the preparation method of valve bracket and pulmonary artery intervention valve |
| CN113599023A (en) * | 2021-07-16 | 2021-11-05 | 复旦大学附属中山医院 | Intervention type artificial heart valve |
| WO2024041251A1 (en) * | 2022-08-22 | 2024-02-29 | 杭州启明医疗器械股份有限公司 | Valve material, method for preparing same and use thereof |
| WO2024041250A1 (en) * | 2022-08-22 | 2024-02-29 | 杭州启明医疗器械股份有限公司 | Polymer valve material, preparation method for integrally molding same, and use thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4575442A (en) * | 1982-12-27 | 1986-03-11 | Ewald Hennig | Making heart valves |
| CN1223560A (en) * | 1996-06-24 | 1999-07-21 | 阿迪亚姆医药技术有限及两合公司 | Cardiac valve prosthesis |
| CN1244107A (en) * | 1997-01-24 | 2000-02-09 | 奥特克欧洲有限公司 | Heart valve prosthesis |
| CN1449267A (en) * | 2000-10-09 | 2003-10-15 | 阿迪亚姆生命科学股份公司 | Cardiac valve prosthesis, especially mitral cardiac valve and method for producing the same |
| US6953332B1 (en) * | 2000-11-28 | 2005-10-11 | St. Jude Medical, Inc. | Mandrel for use in forming valved prostheses having polymer leaflets by dip coating |
| CN103384505A (en) * | 2011-02-18 | 2013-11-06 | D·J·威特利 | Heart valve |
| CN104799975A (en) * | 2015-04-20 | 2015-07-29 | 杭州嘉和众邦生物科技有限公司 | Artificial bioprosthetic heart valve and production method thereof |
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| GB9928905D0 (en) * | 1999-12-08 | 2000-02-02 | Aortech Europ Ltd | Prosthesis |
| US6596024B2 (en) * | 2000-12-21 | 2003-07-22 | Carbomedics Inc. | Polymeric heart valve fabricated from polyurethane/polysiliconeurethane blends |
| US6881224B2 (en) * | 2001-12-28 | 2005-04-19 | St. Jude Medical, Inc. | Fatigue test for prosthetic stent |
| GB2407146B (en) * | 2003-03-20 | 2006-04-26 | Aortech Internat Plc | Valve leaflet for use in cardiac valve prosthesis |
| GB0414099D0 (en) * | 2004-06-23 | 2004-07-28 | Univ Glasgow | Biocompatible layered structures and methods for their manufacture |
| US9833314B2 (en) * | 2010-04-16 | 2017-12-05 | Abiomed, Inc. | Percutaneous valve deployment |
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Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4575442A (en) * | 1982-12-27 | 1986-03-11 | Ewald Hennig | Making heart valves |
| CN1223560A (en) * | 1996-06-24 | 1999-07-21 | 阿迪亚姆医药技术有限及两合公司 | Cardiac valve prosthesis |
| CN1244107A (en) * | 1997-01-24 | 2000-02-09 | 奥特克欧洲有限公司 | Heart valve prosthesis |
| CN1449267A (en) * | 2000-10-09 | 2003-10-15 | 阿迪亚姆生命科学股份公司 | Cardiac valve prosthesis, especially mitral cardiac valve and method for producing the same |
| US6953332B1 (en) * | 2000-11-28 | 2005-10-11 | St. Jude Medical, Inc. | Mandrel for use in forming valved prostheses having polymer leaflets by dip coating |
| CN103384505A (en) * | 2011-02-18 | 2013-11-06 | D·J·威特利 | Heart valve |
| CN104799975A (en) * | 2015-04-20 | 2015-07-29 | 杭州嘉和众邦生物科技有限公司 | Artificial bioprosthetic heart valve and production method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN106726008A (en) | 2017-05-31 |
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