CN106692275A - Pharmaceutical composition for preventing amygdalitis and preparation method of pharmaceutical composition - Google Patents
Pharmaceutical composition for preventing amygdalitis and preparation method of pharmaceutical composition Download PDFInfo
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Abstract
The invention discloses a pharmaceutical composition for preventing amygdalitis and a preparation method of the pharmaceutical composition. The pharmaceutical composition is prepared from centauries, hydrangea xanthoneura roots, esculentoside B, haloragis micrantha and ervatamia kwangsiensis as raw materials by matching, and can be prepared into various medical forms by means of a conventional preparation technology. The pharmaceutical composition has a remarkable therapeutic effect on preventing amygdalitis.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, more particularly to a kind of anti-treating tonsillitis pharmaceutical composition and its preparation side
Method.
Background technology
Chronic proliferative type tonsillitis, the category such as category traditional Chinese medicine " acute tonsillitis ", " tonsillitis wind ".Children and teenager are mainly in,
It is a kind of common, multiple disease of pharynx.The traditional Chinese medical science thinks:Adolescence, develops vigorous, and growth is rapid, excess of YANG-heat, easily
Sense exopathogen；Exopathogen is attacked, unsmoothness of pulmonary qi, and poly- Tianjin is phlegm, and gas hinders for phlegm, qi depression to blood stasis, pent-up throat, larynx core enlargement.The stagnant blood of phlegm
The stasis of blood, strongly fragrant and change heat, it is rotten that heat contains meat, then purulence burns tonsillitis into, heat, then pain；Larynx core enlargement, Airway obstruction, then dysphagia, exhales
Inhale, language is obstructed.This sick interpretation of the cause, onset and process of an illness is:Mental disorder knot, qi depression to blood stasis is hot and suffocating to pent up, discomfort in the throat.Control with clearing heat and detoxicating, profit
Pharynx dissipating bind based on, rectifying qi and dispersing phlegm, it is promoting blood circulation and removing blood stasis supplemented by.
Hydrangea xanthoncura Diels root：This product is Saxifragaceae silk ball platymiscium Huang arteries and veins silk ball Hydrangea xanthoneura
The root of Diels.【Nature and flavor】It is pungent, temperature.【Indication】Promoting blood circulation, reunion of bone.Cure mainly fracture, rheumatic lumbago.【Proterties】
Root cylinder, distortion is about 8cm or longer, diameter about 2mm.Surface taupe, there is vertical wrinkle and radicula or root trace.Crust is easy
Come off, the place that comes off is aobvious faint yellow.Matter is tough, and difficulty fractures, section yellow-white, fibroid.Gas is micro-, taste is pungent.Record in dictionary of medicinal plant.
Ai Lei：This product is the golden flower Centaurium pulchellum Druce of Gentianaceae centaurium hundred
var.al-taicum （Griseb.）Kitag.et Hara[Erythraea ramosissima var.al-taica
Griseb.;Centaurium meyeri（Bunge）Druce ］ wounded in the battle herb.Gathered when blooming, dried.【Nature and flavor】It is bitter；Property
It is cold.【Return through】Liver；Stomach.【Indication】It is clearing heat and detoxicating.Main hepatitis；Cholecystitis；Have a headache and fever；Toothache；Tonsillitis.【It is former
Phytomorph】Annual herb, it is high 20~30 centimetres.The prismatic of stem four, there is branch.Leaf opposite, stockless, lanceolar, long 1.5~2
Centimetre, it is wide 4~6 millimeters.Flower axillary or basidixed, spend more, and calyx 5 splits；Corolla white or lavender, 5 split, and cylindrical fireworks are elongated；Stamen 5,
Flower pesticide Long Circle, Post flowering is crimped in the shape of a spiral.Capsule cylindricality long, 7~September of florescence.Record in dictionary of medicinal plant.
Streamwort:Haloragaceae seaberry streamwort Haloragis micrantha
(Thunb.) herb of R.Br.ex Sidb. Et Zucc. [Goniocarpus micranthus Thunb.].Summer harvests
Herb, cleans, and dries.【Nature and flavor】Bitter；It is puckery；It is cool in nature.【Return through】Return lung；Large intestine；Bladder；It is nontoxic.【Indication】Cough-relieving is put down
Breathe heavily；Clearing heat and promoting diuresis；Regulating menstruation and activating blood.Main cough；Asthma；Heat gonorrhea；Constipation；Dysentery；Irregular menstruation；Fall damage fracture；Furunculosis；Acute mastitis；
Scald；Venomous snake bite.【Former phytomorph】Perennial slim and frahile draft, grows thickly, 20-40cm high.The prismatic of stem four, band russet, directly
Vertical, base portion is crawled branch.Leaf is small, has short handle, opposite, and stem upper leaf is alternate sometimes；The usual egg shape or circular shape of blade, 6- long
10cm, 4-8mm wide, tip is short sharp or blunt, and there is a small tooth at edge, basal circular, and two sides is bald net, light green or puce.Circular cone
Inflorescence basidixed, is made up of thin raceme；Spend small, both sexes；Calyx pipe has rib, and sliver 4, triangle is harbored；Petal 4, it is red；
Stamen 8, flower pesticide aubergine；Gynoecium 1；Ovary is the next, has ratio rib, and style 4, the pink hair of the close life of column cap, drupe is subsphaeroidal,
Be about 1mm, it is bald will and it is bright, have 8 ribs.The month at florescence 6-7, the fruiting period 9-10 months.Record in dictionary of medicinal plant.
Guangxi dog tartar：It is Apocynaceae Ervatamia plant Guangxi dog tartar Ervatamia kwangsiensis
The root skin of Tsiang, leaf.Root skin whole year can adopt, and clean, using fresh herb；Leaf using fresh herb.【Nature and flavor】It is bitter；It is pungent；It is mild-natured.【Indication】Promoting blood circulation
Analgesic.Main traumatic injury；Fracture swells and ache.【Former phytomorph】Shrub, up to 5m.Without hair in addition to spending；Branch and sprig have hole skin,
Internode reaches 2-3cm.Expand and symphysis, oval, up to 2mm on the pretext of leaf base.Leaf opposite；Petiole 5-12mm long；Blade heavily fortified point paper
Matter, ellipticity oval, 5-15cm long, 3-6.5cm wide, tip is short tapering, base portion wedge shape, surface bottle green, back side light green；
Middle arteries are recessed on blade face, overleaf raised；Lateral vein 12-14 pairs, arc rises.Cyme axillary, usual two discrimination, is born in sprig
Top, there is colored 6-7；Total bennet 3-4cm long；Bract and squamella oval；Spend 5 numbers：Bud cylindrical shape；Calyx is wide bell,
Base portion inner face Non-gland body, sepal has echinid；Corolla white, it is caducous；Tube top covers to the left to right rotation, sliver base portion,
There is micro- pubescence on two sides；Stamen is born in nearly gorge portion；The nearly arrow-shaped of flower pesticide；Column cap 2 splits.Follicle radish is twin, 150 ° of forks, round shape long
Lanceolar, has short beak；Carpopodium is about 1cm, fruit 5-6cm long.There is 5-6 in seed Mei Ge Follicle radish.The month at florescence 5-9, fruiting period 9-
November.Record in dictionary of medicinal plant.
Esculentoside B（Phytolaccasaponin B）：CAS 66656-92-6, molecular formula C48H76O21, molecular weight
989.10.【Bioactivity】Anti-inflammatory, anti rheumatism action.【Ingredient origin】Phytolacca acinosa Phytolacca esculenta [Syn.
Phytolacca acinosa]。
1 bulk drug chemical constitution：
Esculentoside B（Phytolaccasaponin B）.
The content of the invention
The purpose of the present invention is to overcome the shortcomings of background technology, there is provided a kind of pharmaceutical composition of effectively anti-treating tonsillitis
And preparation method thereof.
The present invention adopts the following technical scheme that realization：
The composition and weight portion for being made the bulk drug of the pharmaceutical composition of the anti-treating tonsillitis be：
Angstrom flower bud 480-490 weight portion Hydrangea xanthoncura Diels root 450-460 weight portion esculentoside B5-7 weight portion streamworts 380-
390 weight portion Guangxi dog tartar 346-348 weight portions.
The pharmaceutical composition of anti-treating tonsillitis is preferably used in, is made up of the bulk drug of following weight portion：
Angstrom weight portion Guangxi of 485 weight portion Hydrangea xanthoncura Diels root of flower bud, 455 weight portion esculentoside B6 weight portions streamwort 385
The weight portion of dog tartar 347.
A kind of pharmaceutical composition of anti-treating tonsillitis, it is characterised in that pharmaceutical composition can be using the routine of galenic pharmacy
Method prepares piece agent or capsule or dripping pill.
A kind of pharmaceutical composition of anti-treating tonsillitis, it is characterised in that pharmaceutical composition is constituted with chemical drugs or Chinese medicine
Prevent and treat tonsillitis medicine.
A kind of preparation method of the pharmaceutical composition of anti-treating tonsillitis, it is characterised in that prepare as follows：
The composition and weight portion of bulk drug be：Angstrom flower bud 480-490 weight portion Hydrangea xanthoncura Diels root 450-460 weight portion esculentosides
B5-7 weight portion streamwort 380-390 weight portions Guangxi dog tartar 346-348 weight portions；
Preparation method：
（1）Ai Lei, Hydrangea xanthoncura Diels root, esculentoside B, streamwort, Guangxi dog tartar are taken by bulk drug proportioning, is mixed, with weight
The amount ethanol of percent concentration 39% takes as solvent in 33 DEG C of temperature extractions, and extraction time is 17 times, and each extraction time is 43.5
Hour, each solvent load is 46.5 times of bulk drug gross weight, is filtered, and obtains dregs of a decoction A and extract solution A, and extract solution A reclaims second
Alcohol, is concentrated into relative density 1.11, and filtration, liquid is first washed with water by HZ-801 large pore resin absorption columns, then with weight hundred
Divide the ethanol solution of specific concentration 19% wash-out HZ-801 large pore resin absorption columns, collect the ethanol eluate of weight percent concentration 19%,
Ethanol is reclaimed, concentrate drying obtains final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 53% as solvent, heating and refluxing extraction 18 times is carried every time
The time is taken for 0.3 hour, each solvent load is 46 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned
Ethanol is received, relative density 1.05 is concentrated into, filtered, liquid is first washed with water, then use weight by LK08 large pore resin absorption columns
The ethanol solution of percent concentration 74% elutes LK08 large pore resin absorption columns, collects the ethanol eluate of weight percent concentration 74%,
Ethanol is reclaimed, concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Preferred a kind of preparation method of the pharmaceutical composition of anti-treating tonsillitis, it is characterised in that make as follows
It is standby：
The composition and weight portion of bulk drug be：Angstrom weight portion esculentoside B6 weight portions of 485 weight portion Hydrangea xanthoncura Diels root of flower bud 455
The weight portion of 385 weight portion Guangxi dog tartar of streamwort 347；
Preparation method：
（1）Ai Lei, Hydrangea xanthoncura Diels root, esculentoside B, streamwort, Guangxi dog tartar are taken by bulk drug proportioning, is mixed, with weight
The amount ethanol of percent concentration 39% takes as solvent in 33 DEG C of temperature extractions, and extraction time is 17 times, and each extraction time is 43.5
Hour, each solvent load is 46.5 times of bulk drug gross weight, is filtered, and obtains dregs of a decoction A and extract solution A, and extract solution A reclaims second
Alcohol, is concentrated into relative density 1.11, and filtration, liquid is first washed with water by HZ-801 large pore resin absorption columns, then with weight hundred
Divide the ethanol solution of specific concentration 19% wash-out HZ-801 large pore resin absorption columns, collect the ethanol eluate of weight percent concentration 19%,
Ethanol is reclaimed, concentrate drying obtains final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 53% as solvent, heating and refluxing extraction 18 times is carried every time
The time is taken for 0.3 hour, each solvent load is 46 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned
Ethanol is received, relative density 1.05 is concentrated into, filtered, liquid is first washed with water, then use weight by LK08 large pore resin absorption columns
The ethanol solution of percent concentration 74% elutes LK08 large pore resin absorption columns, collects the ethanol eluate of weight percent concentration 74%,
Ethanol is reclaimed, concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
A kind of preparation method of the pharmaceutical composition of anti-treating tonsillitis, it is characterised in that pharmaceutical composition can be using system
The conventional method of agent prepares piece agent or capsule or dripping pill.
A kind of preparation method of the pharmaceutical composition of anti-treating tonsillitis, it is characterised in that pharmaceutical composition and chemical drugs or
Chinese medicine composition prevents and treats tonsillitis medicine.
The anti-treating tonsillitis of pharmaceutical composition are evident in efficacy.
Specific embodiment
Embodiment 1：Pharmaceutical composition of anti-treating tonsillitis and preparation method thereof
The composition and weight portion of the bulk drug of the pharmaceutical composition of anti-treating tonsillitis be：Angstrom flower bud 485g Hydrangea xanthoncura Diels roots 455g
Esculentoside B6g streamwort 385g Guangxi dog tartar 347g；
Preparation method：
（1）Ai Lei, Hydrangea xanthoncura Diels root, esculentoside B, streamwort, Guangxi dog tartar are taken by bulk drug proportioning, is mixed, with weight
The amount ethanol of percent concentration 39% takes as solvent in 33 DEG C of temperature extractions, and extraction time is 17 times, and each extraction time is 43.5
Hour, each solvent load is 46.5 times of bulk drug gross weight, is filtered, and obtains dregs of a decoction A and extract solution A, and extract solution A reclaims second
Alcohol, is concentrated into relative density 1.11, and filtration, liquid is first washed with water by HZ-801 large pore resin absorption columns, then with weight hundred
Divide the ethanol solution of specific concentration 19% wash-out HZ-801 large pore resin absorption columns, collect the ethanol eluate of weight percent concentration 19%,
Ethanol is reclaimed, concentrate drying obtains final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 53% as solvent, heating and refluxing extraction 18 times is carried every time
The time is taken for 0.3 hour, each solvent load is 46 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned
Ethanol is received, relative density 1.05 is concentrated into, filtered, liquid is first washed with water, then use weight by LK08 large pore resin absorption columns
The ethanol solution of percent concentration 74% elutes LK08 large pore resin absorption columns, collects the ethanol eluate of weight percent concentration 74%,
Ethanol is reclaimed, concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Embodiment 2：Pharmaceutical composition of anti-treating tonsillitis and preparation method thereof
The composition and weight portion of the bulk drug of the pharmaceutical composition of anti-treating tonsillitis be：Angstrom flower bud 480g Hydrangea xanthoncura Diels roots 460g
Esculentoside B5g streamwort 390g Guangxi dog tartar 346g；
Preparation method：
（1）Ai Lei, Hydrangea xanthoncura Diels root, esculentoside B, streamwort, Guangxi dog tartar are taken by bulk drug proportioning, is mixed, with weight
The amount ethanol of percent concentration 39% takes as solvent in 33 DEG C of temperature extractions, and extraction time is 17 times, and each extraction time is 43.5
Hour, each solvent load is 46.5 times of bulk drug gross weight, is filtered, and obtains dregs of a decoction A and extract solution A, and extract solution A reclaims second
Alcohol, is concentrated into relative density 1.11, and filtration, liquid is first washed with water by HZ-801 large pore resin absorption columns, then with weight hundred
Divide the ethanol solution of specific concentration 19% wash-out HZ-801 large pore resin absorption columns, collect the ethanol eluate of weight percent concentration 19%,
Ethanol is reclaimed, concentrate drying obtains final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 53% as solvent, heating and refluxing extraction 18 times is carried every time
The time is taken for 0.3 hour, each solvent load is 46 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned
Ethanol is received, relative density 1.05 is concentrated into, filtered, liquid is first washed with water, then use weight by LK08 large pore resin absorption columns
The ethanol solution of percent concentration 74% elutes LK08 large pore resin absorption columns, collects the ethanol eluate of weight percent concentration 74%,
Ethanol is reclaimed, concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Embodiment 3：Pharmaceutical composition of anti-treating tonsillitis and preparation method thereof
The composition and weight portion of the bulk drug of the pharmaceutical composition of anti-treating tonsillitis be：Angstrom flower bud 490g Hydrangea xanthoncura Diels roots 450g
Esculentoside B7g streamwort 380g Guangxi dog tartar 348g；
Preparation method：
（1）Ai Lei, Hydrangea xanthoncura Diels root, esculentoside B, streamwort, Guangxi dog tartar are taken by bulk drug proportioning, is mixed, with weight
The amount ethanol of percent concentration 39% takes as solvent in 33 DEG C of temperature extractions, and extraction time is 17 times, and each extraction time is 43.5
Hour, each solvent load is 46.5 times of bulk drug gross weight, is filtered, and obtains dregs of a decoction A and extract solution A, and extract solution A reclaims second
Alcohol, is concentrated into relative density 1.11, and filtration, liquid is first washed with water by HZ-801 large pore resin absorption columns, then with weight hundred
Divide the ethanol solution of specific concentration 19% wash-out HZ-801 large pore resin absorption columns, collect the ethanol eluate of weight percent concentration 19%,
Ethanol is reclaimed, concentrate drying obtains final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 53% as solvent, heating and refluxing extraction 18 times is carried every time
The time is taken for 0.3 hour, each solvent load is 46 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned
Ethanol is received, relative density 1.05 is concentrated into, filtered, liquid is first washed with water, then use weight by LK08 large pore resin absorption columns
The ethanol solution of percent concentration 74% elutes LK08 large pore resin absorption columns, collects the ethanol eluate of weight percent concentration 74%,
Ethanol is reclaimed, concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Embodiment 4：The preparation of tablet
The pharmaceutical composition 96g of Example 1, adds starch 147g, mixes, and granulation is dried, plus microcrystalline cellulose 32g, stearic acid
Magnesium 2g, mixes, and is pressed into 800, obtains final product medicinal composition tablets.
Embodiment 5：The preparation of capsule
The pharmaceutical composition 263g of Example 2, adds starch 195g, mixes, and granulation is dried, whole grain, adds appropriate stearic acid
Magnesium, mixes, and encapsulated 1200, obtains final product medicament composition capsule.
Embodiment 6：The preparation of dripping pill
Weigh (80 DEG C) heating of Macrogol 6000 316g water-baths and boil molten, add the pharmaceutical composition 14g of embodiment 3, fully stir
Mix uniform, with atoleine as cooling agent, put glass tube（4*80cm）In, chilling temperature is -2 DEG C, and drip internal-and external diameter is 7.0/
2.0 (mm/mm), drip is 2.4cm away from liquid level, and drop speed is optimum condition with every point 50 drop, and the cold of dripping pill surface is blotted with cotton
Solidifying agent, obtains final product medicament composition dropping pills.
Embodiment 7：The pharmaceutical composition of anti-treating tonsillitis
The composition and weight portion of the bulk drug of the pharmaceutical composition of anti-treating tonsillitis be：
The weight portion of 350 weight portion Guangxi dog tartar of angstrom 489 weight portion streamwort of flower bud 300.
Embodiment 8：The pharmaceutical composition of anti-treating tonsillitis
The composition and weight portion of the bulk drug of the pharmaceutical composition of anti-treating tonsillitis be：
The weight portion of 190 weight portion Guangxi dog tartar of esculentoside B1 weight portions streamwort 200.
Embodiment 9：The pharmaceutical composition of anti-treating tonsillitis
The composition and weight portion of the bulk drug of the pharmaceutical composition of anti-treating tonsillitis be：
The weight portion of 300 weight portion Guangxi dog tartar of esculentoside B4 weight portions streamwort 140.
Experimental example 1：The experimental study of anti-treating tonsillitis
1 physical data
46 patients of this group, are clinic case, man 23, female 23.Age is minimum 5 years old, maximum 43 years old；5~12 years old 22,
13~20 years old 16,21~35 years old 6,36~43 2.The course of disease:It is most short half a year, most long 36 years.The state of an illness:Tonsillotome I degree increases
It is raw 12, II degree 20, III degree 12, fibrous type 1,1, crypts type.
2 treatment methods
Combination of oral medication（The pharmaceutical composition of embodiment 1）Composition:Pharmaceutical composition 10g, adds and subtracts with card:Dry and hard excrement is increased
Yellow 5g；Fever caused by exogenous pathogens adds radix bupleuri 8g；Cough ant phlegm adds snakegourd 5g；Larynx core is dark red, or the tip of the tongue has petechia plus spina gleditsiae 3g.Usage:Often
Juice 400ml, morning and evening sub-service are closed in 1 dose of day, decocting 2 times.6 doses is 1 course for the treatment of.Avoid pungent food stimulation and fried thing, and light a fire and help
The product of heat.
3 criterions of therapeutical effect
It is effective:Symptom disappears, and tonsillotome recovers normal size；Or symptom disappears, tonsillotome narrows down to I degree by more than II degree hyperplasia
Size, does not recur for 3 months.
Take a turn for the better:Symptom disappears or mitigates, and the tonsillotome of hyperplasia reduces more than half before relatively treating.
It is invalid:Symptom, sign are unchanged, or aggravate.
4 treatment results
46 patients, take a turn for the better 16 by effective 30, invalid 0, total effective rate 100%.
5 model cases
Zhang, man, 8 years old, student, people from Zaozhuang.The first visit of March 20 in 2011.Its parent is stated:Sore throat, when it is light when weigh 3 years
It is remaining, sleep snoring 2 months.Caught a cold in 3 years causes and take up pharyngeal inflammation, though being moved back through treatment heating, leave larynx core enlargement.This
Afterwards, Chang Yin suffers from cold or catches a cold and induce or aggravate.Usually it is easy to flu, at least more than ten days, at most January number hair, takes up every time
Pharyngeal pain, or dysphagia.Start intravenous infusion penicillin, Piperacillin drips Ancef or CTX afterwards.Slept over nearly 2 months and beaten
Snore, it was originally thought that sleeping posture is bad, often wakes up when sleep, is remained unchanged after changing position.Usually pharyngeal discomfort, likes
Spit.Once seen a doctor in certain ENT dept. of institute, Tonsillectomy is done in doctor's suggestion, still small because considering child's age, spy cures in asking
Treat.Look into:Infant male, physically well develops, and sanity is handsome, and ear nose is normal, III degree of hyperplasia of bilateral amygdala, congested red
Swollen, red tip of tongue, the thin Huang of tongue, neck is soft, and thorax is symmetrical, and cardiopulmonary, belly, liver spleen are normal, remaining discovery without exception, and arteries and veins is slightly counted.Diagnosis:In
Doctor:Acute tonsillitis；Doctor trained in Western medicine:Chronic proliferative type tonsillitis.It is dialectical:Mental disorder knot, qi depression to blood stasis, accumulation of pathogenic heat in the lung.Control with:Heat-clearing is let out
Lung, activating blood circulation and reducing swelling, relieving sore-throat dissipating bind.Give pharmaceutical composition plus spina gleditsiae.6 doses of medication, all cards mitigate, and tonsillotome is contracted to II degree big
It is small.3 courses for the treatment of, symptom is disappeared, and snoring is released, and tonsillotome recovers normal, and disease accuses recovery from illness.
Claims (8)
1. a kind of pharmaceutical composition of anti-treating tonsillitis, it is characterised in that be made the bulk drug of the pharmaceutical composition composition and
Weight portion is：
Angstrom flower bud 480-490 weight portion Hydrangea xanthoncura Diels root 450-460 weight portion esculentoside B5-7 weight portion streamworts 380-
390 weight portion Guangxi dog tartar 346-348 weight portions.
2. a kind of pharmaceutical composition of anti-treating tonsillitis according to claim 1, it is characterised in that be made the drug regimen
The composition and weight portion of the bulk drug of thing be：
Angstrom weight portion Guangxi of 485 weight portion Hydrangea xanthoncura Diels root of flower bud, 455 weight portion esculentoside B6 weight portions streamwort 385
The weight portion of dog tartar 347.
3. a kind of pharmaceutical composition of anti-treating tonsillitis according to claim 1, it is characterised in that pharmaceutical composition can be with
Piece agent or capsule or dripping pill are prepared using the conventional method of galenic pharmacy.
4. a kind of pharmaceutical composition of anti-treating tonsillitis according to claim 1, it is characterised in that pharmaceutical composition with change
What medicine or Chinese medicine were constituted prevents and treats tonsillitis medicine.
5. a kind of preparation method of the pharmaceutical composition of anti-treating tonsillitis, it is characterised in that prepare as follows：
The composition and weight portion of bulk drug be：Angstrom flower bud 480-490 weight portion Hydrangea xanthoncura Diels root 450-460 weight portion esculentosides
B5-7 weight portion streamwort 380-390 weight portions Guangxi dog tartar 346-348 weight portions；
Preparation method：
（1）Ai Lei, Hydrangea xanthoncura Diels root, esculentoside B, streamwort, Guangxi dog tartar are taken by bulk drug proportioning, is mixed, with weight
The amount ethanol of percent concentration 39% takes as solvent in 33 DEG C of temperature extractions, and extraction time is 17 times, and each extraction time is 43.5
Hour, each solvent load is 46.5 times of bulk drug gross weight, is filtered, and obtains dregs of a decoction A and extract solution A, and extract solution A reclaims second
Alcohol, is concentrated into relative density 1.11, and filtration, liquid is first washed with water by HZ-801 large pore resin absorption columns, then with weight hundred
Divide the ethanol solution of specific concentration 19% wash-out HZ-801 large pore resin absorption columns, collect the ethanol eluate of weight percent concentration 19%,
Ethanol is reclaimed, concentrate drying obtains final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 53% as solvent, heating and refluxing extraction 18 times is carried every time
The time is taken for 0.3 hour, each solvent load is 46 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned
Ethanol is received, relative density 1.05 is concentrated into, filtered, liquid is first washed with water, then use weight by LK08 large pore resin absorption columns
The ethanol solution of percent concentration 74% elutes LK08 large pore resin absorption columns, collects the ethanol eluate of weight percent concentration 74%,
Ethanol is reclaimed, concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
6. a kind of preparation method of the pharmaceutical composition of anti-treating tonsillitis according to claim 5, it is characterised in that by such as
It is prepared by lower step：
The composition and weight portion of bulk drug be：Angstrom weight portion esculentoside B6 weight portions of 485 weight portion Hydrangea xanthoncura Diels root of flower bud 455
The weight portion of 385 weight portion Guangxi dog tartar of streamwort 347；
Preparation method：
（1）Ai Lei, Hydrangea xanthoncura Diels root, esculentoside B, streamwort, Guangxi dog tartar are taken by bulk drug proportioning, is mixed, with weight
The amount ethanol of percent concentration 39% takes as solvent in 33 DEG C of temperature extractions, and extraction time is 17 times, and each extraction time is 43.5
Hour, each solvent load is 46.5 times of bulk drug gross weight, is filtered, and obtains dregs of a decoction A and extract solution A, and extract solution A reclaims second
Alcohol, is concentrated into relative density 1.11, and filtration, liquid is first washed with water by HZ-801 large pore resin absorption columns, then with weight hundred
Divide the ethanol solution of specific concentration 19% wash-out HZ-801 large pore resin absorption columns, collect the ethanol eluate of weight percent concentration 19%,
Ethanol is reclaimed, concentrate drying obtains final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 53% as solvent, heating and refluxing extraction 18 times is carried every time
The time is taken for 0.3 hour, each solvent load is 46 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned
Ethanol is received, relative density 1.05 is concentrated into, filtered, liquid is first washed with water, then use weight by LK08 large pore resin absorption columns
The ethanol solution of percent concentration 74% elutes LK08 large pore resin absorption columns, collects the ethanol eluate of weight percent concentration 74%,
Ethanol is reclaimed, concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
7. a kind of preparation method of the pharmaceutical composition of anti-treating tonsillitis according to claim 5, it is characterised in that medicine
Composition can prepare piece agent or capsule or dripping pill using the conventional method of galenic pharmacy.
8. a kind of preparation method of the pharmaceutical composition of anti-treating tonsillitis according to claim 5, it is characterised in that medicine
Composition prevents and treats tonsillitis medicine with chemical drugs or Chinese medicine composition.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611133079.0A CN106692275A (en) | 2016-12-10 | 2016-12-10 | Pharmaceutical composition for preventing amygdalitis and preparation method of pharmaceutical composition |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611133079.0A CN106692275A (en) | 2016-12-10 | 2016-12-10 | Pharmaceutical composition for preventing amygdalitis and preparation method of pharmaceutical composition |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105535044A (en) * | 2016-01-25 | 2016-05-04 | 济南星懿医药技术有限公司 | Medicine composition for preventing and treating encephalatrophy |
| CN105616987A (en) * | 2016-01-25 | 2016-06-01 | 济南星懿医药技术有限公司 | Pharmaceutical composition for preventing and treating prostatic hyperplasia and preparation method thereof |
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2016
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105535044A (en) * | 2016-01-25 | 2016-05-04 | 济南星懿医药技术有限公司 | Medicine composition for preventing and treating encephalatrophy |
| CN105616987A (en) * | 2016-01-25 | 2016-06-01 | 济南星懿医药技术有限公司 | Pharmaceutical composition for preventing and treating prostatic hyperplasia and preparation method thereof |
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Application publication date: 20170524 |