CN106616948A - Cordyceps adenosine-containing healthcare capsule capable of enhancing sexual function - Google Patents
Cordyceps adenosine-containing healthcare capsule capable of enhancing sexual function Download PDFInfo
- Publication number
- CN106616948A CN106616948A CN201710065578.9A CN201710065578A CN106616948A CN 106616948 A CN106616948 A CN 106616948A CN 201710065578 A CN201710065578 A CN 201710065578A CN 106616948 A CN106616948 A CN 106616948A
- Authority
- CN
- China
- Prior art keywords
- extract
- sexual function
- caterpillar fungus
- chinese caterpillar
- health
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 title claims abstract description 50
- 239000002775 capsule Substances 0.000 title claims abstract description 28
- 239000002126 C01EB10 - Adenosine Substances 0.000 title claims abstract description 25
- 229960005305 adenosine Drugs 0.000 title claims abstract description 25
- 230000036299 sexual function Effects 0.000 title claims abstract description 23
- 230000002708 enhancing effect Effects 0.000 title claims abstract description 20
- 241000190633 Cordyceps Species 0.000 title abstract description 4
- 239000000284 extract Substances 0.000 claims abstract description 46
- 235000003140 Panax quinquefolius Nutrition 0.000 claims abstract description 16
- 244000103635 Lyophyllum ulmarium Species 0.000 claims abstract description 15
- 235000015934 Lyophyllum ulmarium Nutrition 0.000 claims abstract description 15
- 230000000694 effects Effects 0.000 claims abstract description 15
- 240000005373 Panax quinquefolius Species 0.000 claims abstract description 14
- 239000000843 powder Substances 0.000 claims abstract description 14
- 229930182490 saponin Natural products 0.000 claims abstract description 11
- 150000007949 saponins Chemical class 0.000 claims abstract description 11
- 235000017709 saponins Nutrition 0.000 claims abstract description 11
- 240000005739 Eurycoma longifolia Species 0.000 claims abstract description 9
- 241000233866 Fungi Species 0.000 claims description 25
- 240000001307 Myosotis scorpioides Species 0.000 claims description 24
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 23
- 238000000605 extraction Methods 0.000 claims description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 14
- 241000606596 Pollia <gastropod> Species 0.000 claims description 10
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 10
- 241000036312 Juniperus coahuilensis Species 0.000 claims description 8
- 238000013461 design Methods 0.000 claims description 8
- 238000004064 recycling Methods 0.000 claims description 8
- 235000007297 Gaultheria procumbens Nutrition 0.000 claims description 7
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 claims description 7
- 239000003480 eluent Substances 0.000 claims description 6
- 239000002250 absorbent Substances 0.000 claims description 3
- 230000002745 absorbent Effects 0.000 claims description 3
- 229920005989 resin Polymers 0.000 claims description 3
- 239000011347 resin Substances 0.000 claims description 3
- 238000010992 reflux Methods 0.000 claims description 2
- 240000001238 Gaultheria procumbens Species 0.000 claims 1
- 239000002023 wood Substances 0.000 claims 1
- 230000004064 dysfunction Effects 0.000 abstract description 5
- 201000010099 disease Diseases 0.000 abstract description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 4
- 201000001881 impotence Diseases 0.000 abstract description 4
- 230000006870 function Effects 0.000 abstract description 3
- 230000006872 improvement Effects 0.000 abstract description 3
- 238000005728 strengthening Methods 0.000 abstract description 3
- 240000000759 Lepidium meyenii Species 0.000 abstract description 2
- 235000000421 Lepidium meyenii Nutrition 0.000 abstract description 2
- 235000012902 lepidium meyenii Nutrition 0.000 abstract description 2
- 241000220317 Rosa Species 0.000 abstract 1
- 208000030047 Sexual desire disease Diseases 0.000 abstract 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 14
- 101100341609 Drosophila melanogaster jing gene Proteins 0.000 description 11
- 238000011771 FVB mouse Methods 0.000 description 10
- 238000002474 experimental method Methods 0.000 description 10
- 239000000463 material Substances 0.000 description 8
- 239000000047 product Substances 0.000 description 8
- 239000000243 solution Substances 0.000 description 8
- 241000699670 Mus sp. Species 0.000 description 7
- 241000736246 Pyrola Species 0.000 description 7
- 235000019441 ethanol Nutrition 0.000 description 7
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 6
- 230000036541 health Effects 0.000 description 6
- 239000006185 dispersion Substances 0.000 description 5
- 238000011049 filling Methods 0.000 description 5
- 235000013305 food Nutrition 0.000 description 5
- 239000013642 negative control Substances 0.000 description 5
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 239000013641 positive control Substances 0.000 description 4
- 206010019233 Headaches Diseases 0.000 description 3
- 231100000869 headache Toxicity 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 230000035946 sexual desire Effects 0.000 description 3
- 239000002002 slurry Substances 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 230000001256 tonic effect Effects 0.000 description 3
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 description 2
- 241000208340 Araliaceae Species 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- 241001248610 Ophiocordyceps sinensis Species 0.000 description 2
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 2
- 230000027326 copulation Effects 0.000 description 2
- 230000002950 deficient Effects 0.000 description 2
- -1 eicosadienoic acid Chemical class 0.000 description 2
- 229960005309 estradiol Drugs 0.000 description 2
- 229930182833 estradiol Natural products 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- 235000008434 ginseng Nutrition 0.000 description 2
- 241000411851 herbal medicine Species 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 210000003899 penis Anatomy 0.000 description 2
- 229960003387 progesterone Drugs 0.000 description 2
- 239000000186 progesterone Substances 0.000 description 2
- 230000009329 sexual behaviour Effects 0.000 description 2
- 230000001568 sexual effect Effects 0.000 description 2
- 238000007920 subcutaneous administration Methods 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- XSXIVVZCUAHUJO-AVQMFFATSA-N (11e,14e)-icosa-11,14-dienoic acid Chemical compound CCCCC\C=C\C\C=C\CCCCCCCCCC(O)=O XSXIVVZCUAHUJO-AVQMFFATSA-N 0.000 description 1
- 241000746976 Agavaceae Species 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- 241001448411 Dracaena draco Species 0.000 description 1
- 235000021297 Eicosadienoic acid Nutrition 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 208000010228 Erectile Dysfunction Diseases 0.000 description 1
- LZKVXMYVBSNXER-YZPKDWIXSA-N Glaucarubin Chemical compound O[C@@H]([C@]1(C)[C@@H]23)[C@@H](O)C=C(C)[C@@H]1C[C@@H]1[C@@]43CO[C@@]2(O)[C@H](O)[C@H](C)[C@@H]4[C@@H](OC(=O)[C@@](C)(O)CC)C(=O)O1 LZKVXMYVBSNXER-YZPKDWIXSA-N 0.000 description 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 1
- 241000581650 Ivesia Species 0.000 description 1
- 206010033307 Overweight Diseases 0.000 description 1
- 241000208343 Panax Species 0.000 description 1
- 241001529246 Platymiscium Species 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- BNRNXUUZRGQAQC-UHFFFAOYSA-N Sildenafil Natural products CCCC1=NN(C)C(C(N2)=O)=C1N=C2C(C(=CC=1)OCC)=CC=1S(=O)(=O)N1CCN(C)CC1 BNRNXUUZRGQAQC-UHFFFAOYSA-N 0.000 description 1
- PDMMFKSKQVNJMI-BLQWBTBKSA-N Testosterone propionate Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](OC(=O)CC)[C@@]1(C)CC2 PDMMFKSKQVNJMI-BLQWBTBKSA-N 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000005238 degreasing Methods 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000035558 fertility Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 235000012041 food component Nutrition 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 150000002338 glycosides Chemical class 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 239000010985 leather Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 201000004792 malaria Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000004089 microcirculation Effects 0.000 description 1
- 238000000874 microwave-assisted extraction Methods 0.000 description 1
- 238000003801 milling Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000010172 mouse model Methods 0.000 description 1
- 235000008935 nutritious Nutrition 0.000 description 1
- 235000020825 overweight Nutrition 0.000 description 1
- 206010036596 premature ejaculation Diseases 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000000384 rearing effect Effects 0.000 description 1
- 230000008327 renal blood flow Effects 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- DEIYFTQMQPDXOT-UHFFFAOYSA-N sildenafil citrate Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O.CCCC1=NN(C)C(C(N2)=O)=C1N=C2C(C(=CC=1)OCC)=CC=1S(=O)(=O)N1CCN(C)CC1 DEIYFTQMQPDXOT-UHFFFAOYSA-N 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000000967 suction filtration Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 229960001712 testosterone propionate Drugs 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 229940094720 viagra Drugs 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/062—Ascomycota
- A61K36/066—Clavicipitaceae
- A61K36/068—Cordyceps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/738—Rosa (rose)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/55—Liquid-liquid separation; Phase separation
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a cordyceps adenosine-containing healthcare capsule capable of enhancing the sexual function. Cordyceps adenosine, American ginseng total saponins, a maca extract and a eurycoma longifolia extract which have the good sexual function enhancing function are used as main functional components and matched with a rose hip extract, pleurotus ulmarius powder and the like to enhance the effects of strengthening bodies and yang, so that the healthcare capsule with the significant sexual function enhancing function is obtained. The healthcare capsule has an obvious improvement effect on sexual desire disorder, impotence, ejaculation dysfunction and other diseases and has a certain body building healthcare effect.
Description
Technical field
The invention belongs to medicines and health protection technical field, and in particular to a kind of health care glue containing Chinese caterpillar fungus adenosine of enhancing sexual function
Capsule.
Background technology
Male sexual disfunction be mainly shown as sexual desire decline, Ejaculatory dysfunction（Premature ejaculation or delay ejaculation）And
Erectile dysfunction.Investigation shows that China has more than one hundred million people to increase with the age with different degrees of sex dysfunction, and the incidence of disease
And increase.Meanwhile, as the quickening of social life rhythm, pressure constantly increase, also there is obvious year in the generation of sex dysfunction
The trend of lightization.And the medicine that used at present is not only expensive, cure the symptoms, not the disease, also often there is headache, face tide
The adverse side effects such as red, stimulation angiocarpy.Therefore, a kind of health product with enhancing sexual function and Tonic Action is developed, with
Meet the eager demand of patient, there is highly important meaning.
The content of the invention
It is an object of the invention to provide a kind of health-caring capsule containing Chinese caterpillar fungus adenosine of enhancing sexual function, it is not only to sexual desire
The illnesss such as obstacle, impotence, defective ejaculation improve significantly, also with the effect of certain body-building health, and Jing research cards
Real, it takes the ill symptomses such as rear no headache, Blushing.
For achieving the above object, the present invention is adopted the following technical scheme that：
A kind of health-caring capsule containing Chinese caterpillar fungus adenosine of enhancing sexual function, its contained functional component includes by weight：Chinese caterpillar fungus gland
Glycosides 10-12 parts, American ginseng total saponins 10-12 parts, agate card extract 6-8 parts, Eurycoma longifolia extract product 6-8 part, fructus rosae are extracted
Thing 8-10 parts, elm mushroom powder 3-8 parts.
Wherein, the elm mushroom powder be by elm mushroom fructification crush after, Jing supercritical COs2Extraction is obtained, and its extraction temperature is
35-50 DEG C, pressure is 10-15MPa, extraction time 80-120min.
Contained functional component also includes at least in thickstiped pollia root extract, wintergreen extract in the health-caring capsule
Kind.The thickstiped pollia root extract be thickstiped pollia root is crushed after, add the water of its weight 5-10 times volume, refluxing extraction 2 times,
Every time 1h, is concentrated to dryness after the merging of gained extract, plus after a small amount of water dissolves, using ADS-17 macroporous absorbent resins, with 30-50
The ethanol solution of vol% is separated for eluant, eluent, eluted, and gained eluent recycling design is crushed to after doing and is obtained.
Cordyceps sinensis is a kind of famous and precious traditional tonic Chinese herbal medicine material, and it not only has strengthen immunity, antitumor, anti-inflammatory etc.
Effect, or the good medicine of Yang nourishing-strengthening.Adenosine composition in Chinese caterpillar fungus is one of main active in Cordyceps sinensis, is also to sentence
One of major criterion of disconnected Chinese caterpillar fungus interior quality.
American Ginseng is Araliaceae Panax tonic Chinese herbal medicine material with ginseng, but different from effect that ginseng qi-tonifying takes off admittedly, west
American ginseng overweights tonifying yin and promotes the production of body fluid, and mends and not dry, therefore deep is always liked by the people of other countries.Contained saponin(e in American Ginseng
Constituents are one of its main compositions, are also the most significant material of physiologically active.
Agate card is a kind of magical plant for originating in Peru, because it has promotion sexual desire, improves fertility, improvement property work(
Can, antidepression the effects such as and by extensive concern.
Tongkat Ali is Simarubaceae Tongkat Ali platymiscium, because it is in treatment malaria, heating and male sexual disfunction etc.
Significant curative effect in disease, and it is referred to as one of Malaysian three big national treasures.
Vitamin C content is highest in all veterinary antibiotics in fructus rosae, therefore has the laudatory title of " king of VC ", and its
It is a kind of rare integration of drinking and medicinal herbs also containing higher unsaturated fatty acids such as eicosadienoic acid, eicosatrienoic acids
Precious resources.Research also find, fructus rosae in addition to nutritious, also with the effects such as salubrity, establishing-Yang.
A kind of distinctive rare fungi of food medicine dual-purpose in Yu Moshi the Northeasts, it is rich in protein, needed by human many
Kind of amino acid and multiple nutritional components, with the multiple efficacies such as benefiting qi and nourishing blood, enriching yin be strong.
Thickstiped pollia root is the root of the short dragon tree of Agavaceae plants, and it has functions that tonifying kidney and strengthening yang.
Wintergreen is the herb of Pyrolaceae wintergreen, and it not only has qi-restoratives, liver protection, the effect of diuresis, also with shield
Effect of kidney and enhancing body, can increase renal blood flow amount, improve microcirculation.
Chinese caterpillar fungus adenosine, American ginseng total saponins, agate card extract, east leather of the present invention to act on good enhancing sexual function
Ali's extract is on the basis of main composition, by coordinating with rose berry extract, elm mushroom powder etc., to obtain one kind and have
Significantly increase the health-caring capsule of sexual function effect.The health-caring capsule not only has bright to illnesss such as dysaphrodisia, impotence, defective ejaculations
Aobvious improvement result, also with the effect of certain body-building health, and Jing researchs confirm that it takes rear no headache, Blushing etc.
Ill symptomses, with preferable market prospects.
Specific embodiment
In order that content of the present invention easily facilitates understanding, with reference to specific embodiment to of the present invention
Technical scheme is described further, but the present invention is not limited only to this.
Chinese caterpillar fungus adenosine used be dry fermented cordyceps hypha body is crushed after, add the water of its 5 times of volume of weight, 500W
Microwave Extraction 2 times, each 10-20min merges extract after filtration, adds the absolute ethyl alcohol of its volume 60 %, quiet after mixing
2-3h is put, is centrifuged, gained supernatant recycling design is crushed to after doing and is obtained.
American ginseng total saponins used are that its weight 10-20 times volume, 30-50 are added in the American Ginseng dry powder of degreasing
The ethanol solution of vol%, ultra high pressure extraction 5-10min under the conditions of 200MPa, then filters, and gained filtrate recycling design is to after doing
Crush and be obtained.
Agate card extract used be by maca powder it is broken after, with the alcohol solution dipping 24h of 85-90 vol% after, then use raw material
Weight 20-30 times volume（g/mL）, 85-90 vol% ethanol solution carry out diacolation, by gained percolate merge, be concentrated to dryness
Crush afterwards and be obtained.
Eurycoma longifolia extract product used be Tongkat Ali is crushed after, the water of its weight 3-5 times volume is added, in 60-80
Heating extraction 1-2h at DEG C, filter, filtrate reduced in volume is to thick slurry shape；It is subsequently adding the ethyl acetate of volume of concentrate 3-5 times
Extraction 2 times, extracts every time 30-60min, collects the ethyl acetate solution after extraction, and by it, reduced pressure concentration is reclaimed at 40-50 DEG C
Solvent is to dry, then adds the ethanol solution of 80-90 vol% dissolve gained solid matter, and Jing activated carbon decolorizings, suction filtration, gained is filtered
Liquid recycling design is crushed to after doing and is obtained.
Rose berry extract used be by fructus rosae clean after, the water for adding its weight 0.5-0.8 times volume is beaten,
Jing after the road of milling treatment of colloid 2, the water for adding 2 times of slurry volume is mixed gained slurries, adds the absolute ethyl alcohol of its volume 40%,
Stir and evenly mix and stand under the conditions of 0-4 DEG C 2-3h, be centrifuged, gained supernatant recycling design is crushed to after doing and is obtained.
Elm mushroom powder used be by elm mushroom fructification crush after, Jing supercritical COs2Extraction is obtained, and its extraction temperature is 35-50
DEG C, pressure is 10-15MPa, extraction time 80-120min.
Thickstiped pollia root extract used be thickstiped pollia root is crushed after, add the water of its weight 5-10 times volume, backflow to carry
Take 2 times, each 1h, gained extract is concentrated to dryness after merging, plus after a small amount of water dissolves, using ADS-17 macroporous absorbent resins,
Separated as eluant, eluent, eluted with the ethanol solution of 30-50 vol%, gained eluent recycling design is crushed to after doing and is obtained；
Wintergreen extract used be wintergreen is crushed after, add the water of its weight 3-5 times volume（g/mL）, heating extraction 1h
After filter, then 3 times of volumes of its weight, the ethanol solution of 60-80 vol% are added in filter residue, mechanical shaking extraction 30-50min merges
Twice recycling design, to dry, crushed and is obtained after extract.
Embodiment 1
A kind of health-caring capsule containing Chinese caterpillar fungus adenosine of enhancing sexual function, its contained functional component is calculated as by weight：Chinese caterpillar fungus adenosine
11 g, the g of American ginseng total saponins 11, the g of agate card extract 8, the g of Eurycoma longifolia extract product 7, the g of rose berry extract 9, elm mushroom powder 4
g。
By above-mentioned formula, each functional component is mixed with auxiliary material, be dried after, Jing is filling to make 2000 capsules, content of dispersion
About 25mg/ grains.
Embodiment 2
A kind of health-caring capsule containing Chinese caterpillar fungus adenosine of enhancing sexual function, its contained functional component is calculated as by weight：Chinese caterpillar fungus adenosine
12 g, the g of American ginseng total saponins 12, the g of agate card extract 7, the g of Eurycoma longifolia extract product 8, the g of rose berry extract 8, elm mushroom powder 3
g。
By above-mentioned formula, each functional component is mixed with auxiliary material, be dried after, Jing is filling to make 2000 capsules, content of dispersion
About 25mg/ grains.
Embodiment 3
A kind of health-caring capsule containing Chinese caterpillar fungus adenosine of enhancing sexual function, its contained functional component is calculated as by weight：Chinese caterpillar fungus adenosine
10 g, the g of American ginseng total saponins 10, the g of agate card extract 6, the g of Eurycoma longifolia extract product 6, the g of rose berry extract 10, elm mushroom powder
8 g。
By above-mentioned formula, each functional component is mixed with auxiliary material, be dried after, Jing is filling to make 2000 capsules, content of dispersion
About 25mg/ grains.
Embodiment 4
A kind of health-caring capsule containing Chinese caterpillar fungus adenosine of enhancing sexual function, its contained functional component is calculated as by weight：Chinese caterpillar fungus adenosine
10 g, the g of American ginseng total saponins 10, the g of agate card extract 6, the g of Eurycoma longifolia extract product 6, the g of rose berry extract 10, elm mushroom powder
5 g, the g of thickstiped pollia root extract 3.
By above-mentioned formula, each functional component is mixed with auxiliary material, be dried after, Jing is filling to make 2000 capsules, content of dispersion
About 25mg/ grains.
Embodiment 5
A kind of health-caring capsule containing Chinese caterpillar fungus adenosine of enhancing sexual function, its contained functional component is calculated as by weight：Chinese caterpillar fungus adenosine
10 g, the g of American ginseng total saponins 10, the g of agate card extract 6, the g of Eurycoma longifolia extract product 6, the g of rose berry extract 10, elm mushroom powder
5 g, the g of wintergreen extract 3.
By above-mentioned formula, each functional component is mixed with auxiliary material, be dried after, Jing is filling to make 2000 capsules, content of dispersion
About 25mg/ grains.
Efficacy test
1. 10 ~ 12 week old health FVB mouse 80 are chosen, and male and female half and half after adaptability is raised one week, male mice are carried out
After sufficiently sexual behaviour training, casual to be divided into blank control group and model group, the quantity ratio of two groups of mouse is 1:7, then by mould
Type group male mice Testectomy under aseptic condition（Control group only does incision of skin, not Testectomy）, month after operation will go
The model group mouse of gesture is randomly divided into negative control group, positive controls and experiment 1-5 groups and is tested.Blank control group and the moon
Property control group normally fills food clear water, positive controls hypodermic injection testosterone propionate（10mg/kg·BW）, experiment 1-5 group difference
Fill food embodiment 1-5 gained capsule 's content（10mg/kg·BW）.
Female FVB mouse 48h hypodermic injection estradiol before experiment（0.5mg/kg·BW）, and the subcutaneous notes of 6h before experiment
Penetrate progesterone（0.5mg/kg·BW）, luring its heat into, 1h is respectively placed in each female FVB mouse in clean mouse cage before experiment,
Per one, cage.
Male mice after administration is respectively put into the mouse cage equipped with female FVB mouse, is made little equipped with male and female in every cage
Mouse is each one, and the number of times of male mice telotism in 30min is then recorded respectively, and it the results are shown in Table 1.
The test result of the castration male mice telotism number of times of table 1
As seen from Table 1, after negative control group mouse castration penis without erection phenomenon, there were significant differences compared with blank control group；
And each experimental group can obviously improve the phenomenon of castration mouse penis anorthosis, its erection number of times is dramatically increased, right with feminine gender
Compare according to group statistically significant.
2. the FVB mouse 80 with normal sexual behavior are chosen, and male and female half and half, sub-cage rearing, adaptability is raised one week
Afterwards, it is divided into blank control group and model group by male FVB mouse are casual, the quantity ratio of two groups of mouse is 1:7, then by model group
Mouse tail is sling, and is hung by the feet in the constant temperature water surface（25±2℃）Upper 20min, one time a day, continuous 10d, to set up chronic suspension stress
Sex dysfunction mouse model, last suspention after next day by model group mouse be randomly divided into negative control group, positive controls and
Experiment 1-5 groups are tested.Blank control group and negative control group normally fill food clear water, and positive controls fill food viagra
（10mg/kg·BW）, experiment 1-5 groups are filled respectively eats embodiment 1-5 gained capsule 's content（10mg/kg·BW）.
Female FVB mouse 48h hypodermic injection estradiol before experiment（0.5mg/kg·BW）, and the subcutaneous notes of 6h before experiment
Penetrate progesterone（0.5mg/kg·BW）, luring its heat into, 1h is respectively placed in each female FVB mouse in clean mouse cage before experiment,
Per one, cage.
After male FVB mouse administration 30min, in being respectively put into the mouse cage equipped with female FVB mouse, make to be filled in every cage
There is male and female mouse each one, male mice in 30min is then recorded respectively and rides number of times and number of copulations, it the results are shown in Table 2.
The male mice sexual function test result of table 2
From table 2, after mouse suspention, it rides number of times and number of copulations is substantially reduced, and has compared with blank control group significantly
Difference；And each experimental group can obviously improve the phenomenon that suspention mouse sexual function weakens, it has system compared with negative control group
Meter learns meaning.
It is demonstrated experimentally that health-caring capsule of the present invention has obvious sexual function humidification by more than, and thickstiped pollia root is added to carry
After taking thing, wintergreen extract, its is better significantly.
The foregoing is only presently preferred embodiments of the present invention, all impartial changes done according to scope of the present invention patent with
Modification, should all belong to the covering scope of the present invention.
Claims (4)
1. the health-caring capsule containing Chinese caterpillar fungus adenosine of a kind of enhancing sexual function, it is characterised in that：Contained functional component is by weight
Including：Chinese caterpillar fungus adenosine 10-12 parts, American ginseng total saponins 10-12 parts, agate card extract 6-8 parts, Eurycoma longifolia extract product 6-8 part,
Rose berry extract 8-10 parts, elm mushroom powder 3-8 parts.
2. the health-caring capsule containing Chinese caterpillar fungus adenosine of enhancing sexual function according to claim 1, it is characterised in that：The elm mushroom powder
Be by elm mushroom fructification crush after, Jing supercritical COs2Extraction is obtained, and its extraction temperature is 35-50 DEG C, and pressure is 10-15MPa,
Extraction time 80-120min.
3. the health-caring capsule containing Chinese caterpillar fungus adenosine of enhancing sexual function according to claim 1, it is characterised in that：Contained effect into
Divide at least one also included in thickstiped pollia root extract, wintergreen extract.
4. the health-caring capsule containing Chinese caterpillar fungus adenosine of enhancing sexual function according to claim 3, it is characterised in that：The big sword
Leaf wood extract be thickstiped pollia root is crushed after, add the water of its weight 5-10 times volume, refluxing extraction 2 times, each 1h, gained
Extract is concentrated to dryness after merging, after being dissolved in water, using ADS-17 macroporous absorbent resins, with the ethanol solution of 30-50 vol%
Separated for eluant, eluent, eluted, gained eluent recycling design is crushed to after doing and is obtained.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710065578.9A CN106616948A (en) | 2017-02-06 | 2017-02-06 | Cordyceps adenosine-containing healthcare capsule capable of enhancing sexual function |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710065578.9A CN106616948A (en) | 2017-02-06 | 2017-02-06 | Cordyceps adenosine-containing healthcare capsule capable of enhancing sexual function |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106616948A true CN106616948A (en) | 2017-05-10 |
Family
ID=58846237
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710065578.9A Pending CN106616948A (en) | 2017-02-06 | 2017-02-06 | Cordyceps adenosine-containing healthcare capsule capable of enhancing sexual function |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106616948A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108096313A (en) * | 2018-02-06 | 2018-06-01 | 张南 | A kind of pharmaceutical composition for treating virile diesae and its preparation method and application |
| JP2020080857A (en) * | 2018-11-14 | 2020-06-04 | 株式会社テクノスルガ・ラボ | Composition for promoting male hormone secretion |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1640488A (en) * | 2004-01-09 | 2005-07-20 | 蒋朝宗 | Method for preparing supermicro powder preparation of cordyceps sinensis mycelium |
| CN1730006A (en) * | 2004-08-04 | 2006-02-08 | 浙江可立思安制药有限公司 | Pharmaceutical composition for treating lung and kidney deficiency and qi, yin insufficiency and preparation method thereof |
| CN102742840A (en) * | 2012-07-16 | 2012-10-24 | 西藏然康科技有限公司 | Maca Cordyceps buccal tablet and preparation method thereof |
| CN106074656A (en) * | 2016-07-27 | 2016-11-09 | 江苏七O七天然制药有限公司 | A kind of Chinese medicinal capsule and preparation technology thereof |
| CN106074655A (en) * | 2016-07-20 | 2016-11-09 | 黄毅 | Nanoscale Eurycoma longifolia and the preparation method of Maca mixed extract |
-
2017
- 2017-02-06 CN CN201710065578.9A patent/CN106616948A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1640488A (en) * | 2004-01-09 | 2005-07-20 | 蒋朝宗 | Method for preparing supermicro powder preparation of cordyceps sinensis mycelium |
| CN1730006A (en) * | 2004-08-04 | 2006-02-08 | 浙江可立思安制药有限公司 | Pharmaceutical composition for treating lung and kidney deficiency and qi, yin insufficiency and preparation method thereof |
| CN102742840A (en) * | 2012-07-16 | 2012-10-24 | 西藏然康科技有限公司 | Maca Cordyceps buccal tablet and preparation method thereof |
| CN106074655A (en) * | 2016-07-20 | 2016-11-09 | 黄毅 | Nanoscale Eurycoma longifolia and the preparation method of Maca mixed extract |
| CN106074656A (en) * | 2016-07-27 | 2016-11-09 | 江苏七O七天然制药有限公司 | A kind of Chinese medicinal capsule and preparation technology thereof |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108096313A (en) * | 2018-02-06 | 2018-06-01 | 张南 | A kind of pharmaceutical composition for treating virile diesae and its preparation method and application |
| WO2019154161A1 (en) * | 2018-02-06 | 2019-08-15 | 海文健康科技（深圳）有限公司 | Pharmaceutical composition for treating male diseases, and preparation method therefor and use thereof |
| JP2020080857A (en) * | 2018-11-14 | 2020-06-04 | 株式会社テクノスルガ・ラボ | Composition for promoting male hormone secretion |
| JP7515817B2 (en) | 2018-11-14 | 2024-07-16 | 株式会社テクノスルガ・ラボ | Composition for promoting male hormone secretion |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101513437B (en) | Antifatigue Chinese pharmaceutical composition and preparation method thereof | |
| CN103627610B (en) | A kind of preparation method of compound Rhodiola rosea wine | |
| CN101804165B (en) | A preparation for clearing kidney toxin, strengthening internal organs, improving body constitution and delaying aging, and its preparation method | |
| CN1762236B (en) | Health-caring product capable of increasing human immunity and its preparation method | |
| CN108524814A (en) | A kind of Chinese medicine composition and preparation method thereof for reducing blood glucose | |
| KR101002774B1 (en) | The invigorate energy food which is made from herb medicine and the producing method thereof | |
| CN102763873B (en) | Rhizoma gastrodiae nutritional beverage and production process thereof | |
| CN105031301A (en) | Anti-tumor traditional Chinese medicine composition and preparation method thereof | |
| CN103155985B (en) | Rhizoma polygonati nutrition powder and preparation method thereof | |
| CN106333022A (en) | Compound cordyceps sinensis and ginseng instant tea and preparation method thereof | |
| CN105770420A (en) | Chinese herbal medicine with anti-cancer effect and preparation method thereof | |
| CN104292353A (en) | Anti-oxidation natural plant polysaccharide and preparation method thereof | |
| CN106616948A (en) | Cordyceps adenosine-containing healthcare capsule capable of enhancing sexual function | |
| CN110075266A (en) | One breeding kidney reinforces the kidney the formula to fill blood and preparation method | |
| CN105412817A (en) | Rhodiola rosea compound oral liquid and preparation method thereof | |
| CN107432911A (en) | A kind of ginseng lozenge of health kidney tonifying and preparation method thereof | |
| CN102784230B (en) | Pharmaceutical composition preparation for treating nutritional anemia | |
| CN102961611A (en) | Health-care medicinal liquor and preparation method thereof | |
| CN102228620B (en) | Chinese medicinal compound preparation having the functions of supplementing iron and enriching the blood and preparation method thereof | |
| WO2017101154A1 (en) | Stomach-nourishing traditional chinese medicine composition and preparation method therefor | |
| CN112402569A (en) | Anti-fatigue health product and preparation method thereof | |
| CN104305179B (en) | Broad-spectrum high efficacy mind calming active blood pressure lowering fat reducing functional food and preparation method thereof | |
| CN110075188A (en) | Edible composition and preparation method thereof | |
| CN103977154A (en) | Pharmaceutical composition for protecting liver | |
| CN102488212A (en) | Health food used for improving sleep, and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170510 |