CN106490053A - A kind of Tickss worm repellant medicament and preparation method thereof - Google Patents
A kind of Tickss worm repellant medicament and preparation method thereof Download PDFInfo
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- 239000005871 repellent Substances 0.000 abstract description 24
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/18—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group —CO—N<, e.g. carboxylic acid amides or imides; Thio analogues thereof
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- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
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- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Abstract
一种蜱虫驱避剂药剂及其制备方法，由下述原料制成：驱蜱中药药液、避蚊胺、香精、酒精，驱蜱中药药液由下述中药原料制成：苦楝皮、槟榔、使君子、鹤虱、贯众、马鞭草、香茅草、蛇床子、薰衣草、雷公藤、苹婆、夏枯草、万寿菊、逐蝇梅。本发明采用中药成分和化工原料相结合的方式，充分发挥中药成分对人体刺激小、长期使用副作用低的特点，并且有效提高对蜱虫的防护性，长期使用仍然能够保持高效的驱虫效果。本发明可以涂覆在裸露皮肤表面，也可以采用喷雾瓶喷涂，使用方便。驱蜱持续时间长，一次喷涂可以保持12h，驱蜱效果好。A tick repellent agent and its preparation method, which is made of the following raw materials: tick repelling traditional Chinese medicinal liquid, DEET, essence, alcohol, and the tick repellent traditional Chinese medicinal liquid is made of the following traditional Chinese medicinal raw materials: neem bark, Betel nut, Shijunzi, Crane Lice, Guanzhong, Verbena, Lemongrass, Cnidium, Lavender, Tripterygium wilfordii, Pingpo, Prunella vulgaris, Marigold, Muscaria chinensis. The invention adopts the method of combining traditional Chinese medicine ingredients and chemical raw materials to give full play to the characteristics of the traditional Chinese medicine ingredients that are less irritating to the human body and has low side effects after long-term use, and effectively improves the protection against ticks, and can still maintain high-efficiency insect repelling effect after long-term use. The present invention can be coated on the exposed skin surface, and can also be sprayed by using a spray bottle, which is convenient to use. Tick repelling lasts for a long time, one spray can last for 12 hours, and the tick repelling effect is good.
Description
技术领域technical field
本发明属于驱蜱药物领域，具体地说是一种蜱虫驱避剂药剂及其制备方法。The invention belongs to the field of tick repelling drugs, in particular to a tick repellent medicament and a preparation method thereof.
背景技术Background technique
蜱也叫壁虱、鳖吃，蛰伏在浅山丘陵的草丛、植物上，或寄宿于牲畜等动物皮毛间。蜱叮咬的无形体病属于传染病，人对此病普遍易感，与危重患者有密切接触、直接接触病人血液等体液的医务人员或其陪护者，如不注意防护，也可能感染。目前，对于裸露皮肤采用在其表面喷涂驱避剂，现有的蜱虫驱避剂多采用化工药物制剂，适合多时间临时使用，对于长期在野外、疫区的工作人员经常使用会造成皮肤过敏、瘙痒等副作用，蜱虫可能对其产生抗药性，长时间使用效果下降明显。Ticks are also called ticks and turtles. They lie dormant on the grass and plants in shallow mountains and hills, or live in the fur of animals such as livestock. Anaplasma disease caused by tick bites is an infectious disease. People are generally susceptible to this disease. Medical staff or their attendants who have close contact with critically ill patients or directly contact the patient's blood and other body fluids may also be infected if they do not pay attention to protection. At present, the exposed skin is sprayed with repellent on its surface. Most of the existing tick repellents use chemical pharmaceutical preparations, which are suitable for temporary use for a long time. Frequent use of workers in the wild and in epidemic areas will cause skin allergies , itching and other side effects, ticks may develop resistance to it, and the effect will decrease significantly after long-term use.
发明内容Contents of the invention
本发明提供一种蜱虫驱避剂药剂及其制备方法，用以解决现有技术中的缺陷。The invention provides a tick repellent medicament and a preparation method thereof, which are used to solve the defects in the prior art.
本发明通过以下技术方案予以实现：The present invention is achieved through the following technical solutions:
一种蜱虫驱避剂药剂及其制备方法，由下述重量份原料制成：驱蜱中药药液30-50份、避蚊胺10-20份、香精2-5份、酒精20-40份，驱蜱中药药液由下述重量份中药原料制成：苦楝皮5-10份、槟榔8-12份、使君子7-13份、鹤虱5-10份、贯众5-10份、马鞭草3-8份、香茅草6-10份、蛇床子2-5份、薰衣草3-5份、雷公藤6-8份、苹婆3-8份、夏枯草2-6份、万寿菊5-10份、逐蝇梅6-8份。A tick repellent agent and a preparation method thereof, which are made of the following raw materials in parts by weight: 30-50 parts of tick repelling traditional Chinese medicine liquid, 10-20 parts of DEET, 2-5 parts of essence, and 20-40 parts of alcohol The anti-tick traditional Chinese medicinal liquid is made of the following traditional Chinese medicine raw materials in parts by weight: 5-10 parts of neem bark, 8-12 parts of betel nut, 7-13 parts of Shijunzi, 5-10 parts of crane lice, and 5-10 parts of Guanzhong , Verbena 3-8 parts, Lemongrass 6-10 parts, Cnidium 2-5 parts, Lavender 3-5 parts, Tripterygium 6-8 parts, Pingpo 3-8 parts, Prunella vulgaris 2-6 parts, Longevity 5-10 parts of chrysanthemum, 6-8 parts of chrysanthemum.
如上所述的一种蜱虫驱避剂药剂及其制备方法，所述的驱蜱中药药液由下述重量份中药原料制成：苦楝皮5份、槟榔10份、使君子13份、鹤虱5份、贯众7份、马鞭草8份、香茅草6份、蛇床子3份、薰衣草5份、雷公藤6份、苹婆5份、夏枯草6份、万寿菊5份、逐蝇梅7份。A kind of tick repellent agent and its preparation method as described above, the described tick repellent traditional Chinese medicine liquid is made of the following traditional Chinese medicine raw materials: 5 parts of neem bark, 10 parts of betel nut, 13 parts of Shi Junzi, crane 5 parts of lice, 7 parts of peony, 8 parts of verbena, 6 parts of citronella, 3 parts of Cnidium, 5 parts of lavender, 6 parts of Tripterygium wilfordii, 5 parts of Prunella, 6 parts of Prunella vulgaris, 5 parts of marigold, and chasing flies 7 servings of plum.
如上所述的一种蜱虫驱避剂药剂及其制备方法，所述的驱蜱中药药液由下述重量份中药原料制成：苦楝皮7份、槟榔12份、使君子7份、鹤虱8份、贯众10份、马鞭草3份、香茅草8份、蛇床子5份、薰衣草3份、雷公藤7份、苹婆8份、夏枯草2份、万寿菊7份、逐蝇梅8份。A kind of tick repellent agent and its preparation method as described above, the described tick repellent traditional Chinese medicine liquid is made of the following traditional Chinese medicine raw materials: 7 parts of neem bark, 12 parts of betel nut, 7 parts of Shijunzi, crane 8 parts of lice, 10 parts of peony, 3 parts of verbena, 8 parts of citronella, 5 parts of Cnidium, 3 parts of lavender, 7 parts of Tripterygium wilfordii, 8 parts of Prunella, 2 parts of Prunella vulgaris, 7 parts of marigold, and chasing flies 8 servings of plum.
如上所述的一种蜱虫驱避剂药剂及其制备方法，所述的驱蜱中药药液由下述重量份中药原料制成：苦楝皮10份、槟榔8份、使君子10份、鹤虱10份、贯众5份、马鞭草6份、香茅草10份、蛇床子2份、薰衣草4份、雷公藤8份、苹婆3份、夏枯草4份、万寿菊10份、逐蝇梅6份。A tick repellent agent as described above and its preparation method, the described tick repelling Chinese medicine liquid is made of the following Chinese medicine raw materials in parts by weight: 10 parts of neem bark, 8 parts of betel nut, 10 parts of Shijunzi, crane 10 parts of lice, 5 parts of rhubarb, 6 parts of verbena, 10 parts of citronella, 2 parts of cnidium, 4 parts of lavender, 8 parts of tripterygium, 3 parts of apple, 4 parts of Prunella vulgaris, 10 parts of marigold, chasing flies 6 servings of plum.
如上所述的一种蜱虫驱避剂药剂及其制备方法，所述的驱蜱中药药液由下述方法制成： ①将各中药原料在水中浸泡2-3h，待用； ②取苦楝皮、鹤虱、贯众、马鞭草、蛇床子、逐蝇梅加入至容器中，武火煎药10-15min，其中鹤虱、蛇床子、逐蝇梅采用包煎； ③再向槟榔、使君子、香茅草、薰衣草、雷公藤、苹婆、夏枯草、万寿菊加入至容器中，武火煎药10-15min，其中使君子、苹婆采用包煎； ④文火继续煎药至药液为最初加水量的3/4-2/3时，停止煎药，过滤得到驱蜱中药药液，冷却至常温即可使用。The above-mentioned tick repellant agent and its preparation method, the described tick repellent Chinese medicine liquid is made by the following method: ① Soak each Chinese medicine raw material in water for 2-3 hours, and set aside; ② Take neem Add the skin, crane lice, guanzhong, verbena, cnidium, and fly plum into the container, and decoct them with fire for 10-15 minutes, of which the crane lice, cnidium, and fly plum are fried in bags; , Lemongrass, Lavender, Tripterygium wilfordii, Pingpo, Prunella vulgaris, and Marigold are added to the container, and the medicine is decocted for 10-15 minutes. When the water volume is 3/4-2/3, stop decocting, filter to get tick repelling traditional Chinese medicine liquid, cool to normal temperature and then use.
如上所述的一种蜱虫驱避剂药剂及其制备方法，由下述重量份原料制成：驱蜱中药药液30份、避蚊胺15份、香精5份、酒精20份。The above-mentioned tick repellent medicament and its preparation method are made of the following raw materials in parts by weight: 30 parts of tick repelling traditional Chinese medicine liquid, 15 parts of DEET, 5 parts of essence, and 20 parts of alcohol.
如上所述的一种蜱虫驱避剂药剂及其制备方法，由下述重量份原料制成：驱蜱中药药液40份、避蚊胺20份、香精2份、酒精30份。The above-mentioned tick repellent medicament and its preparation method are made of the following raw materials in parts by weight: 40 parts of tick repelling traditional Chinese medicine liquid, 20 parts of DEET, 2 parts of essence, and 30 parts of alcohol.
如上所述的一种蜱虫驱避剂药剂及其制备方法，由下述重量份原料制成：驱蜱中药药液50份、避蚊胺10份、香精3份、酒精40份。The above-mentioned tick repellent medicament and its preparation method are made of the following raw materials in parts by weight: 50 parts of tick repelling traditional Chinese medicine liquid, 10 parts of DEET, 3 parts of essence, and 40 parts of alcohol.
一种蜱虫驱避剂药剂及其制备方法，将驱蜱中药药液、避蚊胺、香精、酒精加入反应釜，搅拌1-2小时，静置5-7小时，制得蜱蜱虫驱避剂药剂。A kind of tick repellent medicament and preparation method thereof, adding tick repellent traditional Chinese medicinal liquid, DEET, essence, alcohol into reaction kettle, stirring for 1-2 hours, standing for 5-7 hours, and making tick repellent Avoidant medicine.
本发明的优点是：本发明采用中药成分和化工原料相结合的方式，充分发挥中药成分对人体刺激小、长期使用副作用低的特点，并且有效提高对蜱虫的防护性，长期使用仍然能够保持高效的驱虫效果。本发明可以涂覆在裸露皮肤表面，也可以采用喷雾瓶喷涂，使用方便。驱蜱持续时间长，一次喷涂可以保持12h，驱蜱效果好。The advantages of the present invention are: the present invention adopts the method of combining traditional Chinese medicine ingredients and chemical raw materials, fully exerts the characteristics of Chinese medicine ingredients that are less irritating to the human body, and has low side effects after long-term use, and effectively improves the protection against ticks, and can still maintain long-term use. Efficient insect repellent effect. The present invention can be coated on the exposed skin surface, and can also be sprayed by using a spray bottle, which is convenient to use. Tick repelling lasts for a long time, one spray can last for 12 hours, and the tick repelling effect is good.
具体实施方式detailed description
为使本发明实施例的目的、技术方案和优点更加清楚，下面将对本发明实施例中的技术方案进行清楚、完整地描述，显然，所描述的实施例是本发明一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有作出创造性劳动前提下所获得的所有其他实施例，都属于本发明保护的范围。In order to make the purpose, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are part of the embodiments of the present invention, not all of them. the embodiment. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without creative efforts fall within the protection scope of the present invention.
一种蜱虫驱避剂药剂及其制备方法，由下述重量份原料制成：驱蜱中药药液30-50份、避蚊胺10-20份、香精2-5份、酒精20-40份，驱蜱中药药液由下述重量份中药原料制成：苦楝皮5-10份、槟榔8-12份、使君子7-13份、鹤虱5-10份、贯众5-10份、马鞭草3-8份、香茅草6-10份、蛇床子2-5份、薰衣草3-5份、雷公藤6-8份、苹婆3-8份、夏枯草2-6份、万寿菊5-10份、逐蝇梅6-8份。A tick repellent agent and a preparation method thereof, which are made of the following raw materials in parts by weight: 30-50 parts of tick repelling traditional Chinese medicine liquid, 10-20 parts of DEET, 2-5 parts of essence, and 20-40 parts of alcohol The anti-tick traditional Chinese medicinal liquid is made of the following traditional Chinese medicine raw materials in parts by weight: 5-10 parts of neem bark, 8-12 parts of betel nut, 7-13 parts of Shijunzi, 5-10 parts of crane lice, and 5-10 parts of Guanzhong , Verbena 3-8 parts, Lemongrass 6-10 parts, Cnidium 2-5 parts, Lavender 3-5 parts, Tripterygium 6-8 parts, Pingpo 3-8 parts, Prunella vulgaris 2-6 parts, Longevity 5-10 parts of chrysanthemum, 6-8 parts of chrysanthemum.
具体的，所述的一种蜱虫驱避剂药剂及其制备方法由下述实施例的重量份中药原料制成：Specifically, the described a tick repellent agent and its preparation method are made from the traditional Chinese medicine raw materials of the following examples in parts by weight:
实施例一：驱蜱中药药液30份、避蚊胺15份、香精5份、酒精20份。其中驱蜱中药药液由下述重量份中药原料制成：苦楝皮5份、槟榔10份、使君子13份、鹤虱5份、贯众7份、马鞭草8份、香茅草6份、蛇床子3份、薰衣草5份、雷公藤6份、苹婆5份、夏枯草6份、万寿菊5份、逐蝇梅7份。Embodiment 1: 30 parts of Tick Repelling Traditional Chinese Medicine Liquid, 15 parts of DEET, 5 parts of Essence, 20 parts of Alcohol. Wherein the anti-tick traditional Chinese medicinal liquid is made from the following traditional Chinese medicine raw materials in parts by weight: 5 parts of neem bark, 10 parts of betel nut, 13 parts of gentleman, 5 parts of crane louse, 7 parts of rhododendron, 8 parts of verbena, 6 parts of citronella, 3 parts of Fructus Cnidii, 5 parts of Lavender, 6 parts of Tripterygium wilfordii, 5 parts of Prunella vulgaris, 6 parts of Prunella vulgaris, 5 parts of Marigold, 7 parts of Prunus chinensis.
实施例二：驱蜱中药药液40份、避蚊胺20份、香精2份、酒精30份。其中驱蜱中药药液由下述重量份中药原料制成：苦楝皮7份、槟榔12份、使君子7份、鹤虱8份、贯众10份、马鞭草3份、香茅草8份、蛇床子5份、薰衣草3份、雷公藤7份、苹婆8份、夏枯草2份、万寿菊7份、逐蝇梅8份。Example 2: 40 parts of Tick Repelling Traditional Chinese Medicine Liquid, 20 parts of DEET, 2 parts of Essence, 30 parts of Alcohol. Wherein the anti-tick traditional Chinese medicinal liquid is made of the following traditional Chinese medicine raw materials in parts by weight: 7 parts of neem bark, 12 parts of betel nut, 7 parts of gentleman, 8 parts of crane louse, 10 parts of rhododendron, 3 parts of verbena, 8 parts of citronella, 5 parts of Fructus Cnidii, 3 parts of Lavender, 7 parts of Tripterygium wilfordii, 8 parts of Prunus vulgaris, 2 parts of Prunella vulgaris, 7 parts of Marigold, and 8 parts of Prunus chinensis.
实施例三：驱蜱中药药液50份、避蚊胺10份、香精3份、酒精40份。其中驱蜱中药药液由下述重量份中药原料制成：苦楝皮10份、槟榔8份、使君子10份、鹤虱10份、贯众5份、马鞭草6份、香茅草10份、蛇床子2份、薰衣草4份、雷公藤8份、苹婆3份、夏枯草4份、万寿菊10份、逐蝇梅6份。Embodiment 3: 50 parts of tick repelling traditional Chinese medicinal liquid, 10 parts of DEET, 3 parts of essence, and 40 parts of alcohol. Wherein the anti-tick traditional Chinese medicinal liquid is made of the following traditional Chinese medicine raw materials in parts by weight: 10 parts of neem bark, 8 parts of betel nut, 10 parts of gentleman, 10 parts of crane louse, 5 parts of rhododendron, 6 parts of verbena, 10 parts of citronella, 2 parts of Cnidium, 4 parts of Lavender, 8 parts of Tripterygium wilfordii, 3 parts of Prunella vulgaris, 4 parts of Prunella vulgaris, 10 parts of Marigold, and 6 parts of Prunus chinensis.
将本发明在纸片涂覆环形，环形的直径为20cm左右，圆环的宽度为5cm，取未吸血蜱虫50只放置在纸片中央，每个3h记录一次环形内的蜱虫数量，结果如下表所示：The present invention is coated ring-shaped on the paper sheet, the diameter of the ring is about 20cm, the width of the ring is 5cm, take 50 non-blood-sucking ticks and place them in the center of the paper sheet, record the number of ticks in the ring every 3h, the result As shown in the table below:
上表可以看出，12h后的趋避率（趋避率=剩余蜱虫数量/原始蜱虫数量）仍然大于90%，趋避效果好。It can be seen from the above table that the avoidance rate after 12 hours (avoidance rate = number of remaining ticks/number of original ticks) is still greater than 90%, and the avoidance effect is good.
对一批次蜱虫饲养并每天使用本发明趋避，保持繁殖3-5代后，采用上述方法进行测试，12h后的趋避率仍然大于90%。Feed a batch of ticks and use the repelling method of the present invention every day. After keeping breeding for 3-5 generations, the above-mentioned method is used to test, and the repelling rate after 12 hours is still greater than 90%.
所述的驱蜱中药药液由下述方法制成： ①将各中药原料在水中浸泡2-3h，待用；②取苦楝皮、鹤虱、贯众、马鞭草、蛇床子、逐蝇梅加入至容器中，武火煎药10-15min，其中鹤虱、蛇床子、逐蝇梅采用包煎； ③再向槟榔、使君子、香茅草、薰衣草、雷公藤、苹婆、夏枯草、万寿菊加入至容器中，武火煎药10-15min，其中使君子、苹婆采用包煎； ④文火继续煎药至药液为最初加水量的3/4-2/3时，停止煎药，过滤得到驱蜱中药药液，冷却至常温即可使用。The described tick-repelling traditional Chinese medicinal liquid is prepared by the following method: ① soak each raw material of traditional Chinese medicine in water for 2-3 hours, and set aside; Add it to the container and decoct it with high fire for 10-15 minutes, among which, crane lice, cnidium, and fly plum are fried in a bag; Add it into the container and decoct the medicine for 10-15 minutes with strong fire, among which the gentlemen and pingpo are decocted in a bag; ④Continue to decoct the medicine with a slow fire until the medicine liquid is 3/4-2/3 of the initial water amount, stop the decoction, and filter to obtain Tick repelling traditional Chinese medicine liquid, cooled to room temperature can be used.
一种蜱虫驱避剂药剂及其制备方法，将驱蜱中药药液、避蚊胺、香精、酒精加入反应釜，搅拌1-2小时，静置5-7小时，制得蜱虫驱避剂药剂。A tick repellent medicament and a preparation method thereof, comprising adding tick repellent traditional Chinese medicinal liquid, DEET, essence, and alcohol into a reaction kettle, stirring for 1-2 hours, and standing for 5-7 hours to obtain tick repellent dose of medicine.
最后应说明的是：以上实施例仅用以说明本发明的技术方案，而非对其限制；尽管参照前述实施例对本发明进行了详细的说明，本领域的普通技术人员应当理解：其依然可以对前述各实施例所记载的技术方案进行修改，或者对其中部分技术特征进行等同替换；而这些修改或者替换，并不使相应技术方案的本质脱离本发明各实施例技术方案的精神和范围。Finally, it should be noted that: the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit them; although the present invention has been described in detail with reference to the foregoing embodiments, those of ordinary skill in the art should understand that: it can still be Modifications are made to the technical solutions described in the foregoing embodiments, or equivalent replacements are made to some of the technical features; and these modifications or replacements do not make the essence of the corresponding technical solutions deviate from the spirit and scope of the technical solutions of the various embodiments of the present invention.
Claims (9)
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