CN106473837A - Artificial cornea - Google Patents
Artificial cornea Download PDFInfo
- Publication number
- CN106473837A CN106473837A CN201610153120.4A CN201610153120A CN106473837A CN 106473837 A CN106473837 A CN 106473837A CN 201610153120 A CN201610153120 A CN 201610153120A CN 106473837 A CN106473837 A CN 106473837A
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- CN
- China
- Prior art keywords
- artificial cornea
- cornea
- central optical
- artificial
- coating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/142—Cornea, e.g. artificial corneae, keratoprostheses or corneal implants for repair of defective corneal tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/0077—Special surfaces of prostheses, e.g. for improving ingrowth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/30—Inorganic materials
- A61L27/306—Other specific inorganic materials not covered by A61L27/303 - A61L27/32
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/0077—Special surfaces of prostheses, e.g. for improving ingrowth
- A61F2002/009—Special surfaces of prostheses, e.g. for improving ingrowth for hindering or preventing attachment of biological tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
- A61L2300/104—Silver, e.g. silver sulfadiazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
Landscapes
- Health & Medical Sciences (AREA)
- Transplantation (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Prostheses (AREA)
- Materials For Medical Uses (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a kind of artificial cornea, it includes central optical part and is located at the standing part of periphery, it is characterised in that：A nanometer silver coating (3) is coated with the cylinder side external surface of the artificial cornea central optical part and the inner surface of standing part (2).The average grain diameter of the nanoparticle of described coating is 20nm.It is an advantage of the current invention that the antibacterial characteristics having using the isolation of coating and Nano Silver, after being coated onto artificial cornea opticator cylindrical outer surface and periphery fixture inner surface, killing action is produced to microorganisms such as the bacteriums that contacts with patient's cornea, aqueous humor；As Nano Silver can be coated in permanence around artificial cornea opticator, do not change the artificial cornea material feature of itself, the inherent characteristic that artificial cornea has still is kept, make treatment, nursing reach best effect.
Description
Technical field
The present invention relates to pharmaceutical technology field, is specifically related to a kind of artificial cornea.
Background technology
Artificial cornea is the hand of finally recovering lost eyesight of the opacity of the cornea patient that cannot be recovered lost eyesight with operation on cornea
Section.For reaching preferable optical effect, artificial cornea is many at present using through, i.e., artificial angle
Opticator is fixed on Central corneal by support by film opticator insertion cornea holostrome, because
There is certain gap between this artificial optics of cornea part and peripheral bracket and institutional framework.Due to existing
Artificial cornea not have sterilizing function, during the use of artificial cornea, easily cause infection,
Treatment, nursery work to disease brings very big inconvenience, brings pain to patient, sometimes even
Entophthamia is occurred even to lose the danger of eyeball.
Content of the invention
It is an object of the invention to provide a kind of medical artificial cornea with antibacterial functions, in order to
Infection rate during the use of minimizing artificial cornea.
For achieving the above object, the present invention can take following technical proposals：
The invention provides a kind of artificial cornea, it includes central optical part and is located at periphery
Standing part, it is characterised in that：Cylindrical side appearance in the artificial cornea central optical part
The inner surface of face and standing part (2) is coated with a nanometer silver coating (3).
Preferably, described central optic is divided into central optical mirror post (1), described fixation
Partly (2) are fixture or posterior surface of cornea fixture between corneal lamellar.
Preferably, the material of described central optical mirror post (1) is medical grade polymethylacrylic acid
Methyl esters and/or hydroxyethyl methacrylate.
Preferably, between described corneal lamellar, fixture or posterior surface of cornea fixture materials are selected from
Medical grade polymethylmethacrylacontinuous or medical rank titanium.
The average grain diameter of the nanoparticle of described nanometer silver coating (3) is 1～100nm, preferably
5～50nm, more preferably 10～40nm, most preferably 20nm.
It is an advantage of the current invention that the antibacterial characteristics having using the isolation of coating and Nano Silver,
It is coated onto the inner surface of artificial cornea opticator cylindrical outer surface and periphery standing part
Afterwards, killing action is produced to microorganisms such as the bacteriums that contacts with patient's cornea, aqueous humor；Due to receiving
Rice silver coating can be coated in permanence around artificial cornea opticator, do not change artificial cornea
The feature of material itself, the inherent characteristic that artificial cornea has still are kept, and make treatment, shield
Reason reaches best effect.
Description of the drawings
The invention will be further described below in conjunction with the accompanying drawings.
Fig. 1 be central optical mirror post (1) of artificial cornea of the present invention, periphery standing part and its
The structural representation of nano surface silver coating (3).
Fig. 2 be to employing the polymethyl methacrylate cornea (cornea of nano-Ag particles coating
Diameter 10mm, thickness 1mm) Antibacterial Property test example.Wherein PMMA is represented
Polymethyl methacrylate cornea group, SNP-PMMA are represented and employ nano-Ag particles coating
Polymethyl methacrylate cornea group.
Fig. 3 a is to employ the polymethyl methacrylate cornea of nano-Ag particles coating and do not make
The number of planktonic bacteria minimizing is compared with the polymethyl methacrylate cornea of nano-Ag particles coating
Diagram.Fig. 3 b be employ the polymethyl methacrylate cornea of nano-Ag particles coating with not
The number of adherent bacteria minimizing is compared using the polymethyl methacrylate cornea of nano-Ag particles coating
Purpose is illustrated.
Specific embodiment
Technical scheme is further detailed below by way of specific embodiment and
Description.It will be appreciated by persons skilled in the art that detailed description below is only to be
It is expanded on further the purpose of the present invention, rather than limits the scope of the invention by any way.
Embodiment 1
As shown in figure 1, the antibacterial medical artificial cornea of present invention description includes central optical mirror post
(1), the standing part (2) of periphery is located at and in the artificial cornea central optical mirror post (1)
Cylinder side external surface and the inner surface of periphery standing part (2) be coated with a nanometer silver coating (3),
The average grain diameter of the nanoparticle of the coating is 20nm.
Inventor passes through in vitro test to employing the poly- methyl-prop of nano-Ag particles coating
The antibacterial characteristics of e pioic acid methyl ester cornea (corneal diameter 10mm, thickness 1mm) are studied,
See Fig. 2, as a result confirm the cornea with nano-Ag particles coating and there is no nano-Ag particles coating
Cornea compare, the former to MRSE (Sep, ATCC 12228), golden yellow make purulence
Staphylococcus (Sau, ATCC 25923) and Pseudomonas aeruginosa (Pae, ATCC27853) tool
There is obvious inhibitory action (P<0.05, unidirectional ANOVA statistical method).
Embodiment 2
As shown in figure 1, the antibacterial medical artificial cornea of present invention description includes central optical mirror post
(1), the standing part (2) of periphery is located at and in the artificial cornea central optical mirror post (1)
Cylinder side external surface and the inner surface of periphery standing part (2) be coated with a nanometer silver coating (3),
The average grain diameter of the nanoparticle of the coating is 40nm.
Inventor passes through in vitro test to employing the poly- methyl-prop of nano-Ag particles coating
The antibacterial characteristics of e pioic acid methyl ester cornea (corneal diameter 10mm, thickness 1mm) are studied,
See Fig. 3 a, Fig. 3 b, as a result confirm the cornea with nano-Ag particles coating and there is no Nano Silver
The cornea of grain coating is compared, and the former has significantly suppression to table adherent bacteria and planktonic bacteria
Effect (P<0.05, unidirectional ANOVA statistical method).
Claims (7)
1. a kind of artificial cornea, it include central optical part and be located at the standing part of periphery,
It is characterized in that：Cylinder side external surface and fixed part in the artificial cornea central optical part
The inner surface of (2) is divided to be coated with a nanometer silver coating (3).
2. artificial cornea according to claim 1, it is characterised in that：Described central optical
The department of the Chinese Academy of Sciences is divided into central optical mirror post (1), and described standing part (2) is fixing between corneal lamellar
Thing or posterior surface of cornea fixture.
3. artificial cornea according to claim 2, it is characterised in that：Described central optical
The material for learning mirror post (1) is medical grade polymethylmethacrylacontinuous and/or hydroxyethyl methacrylate.
4. artificial cornea according to claim 2, it is characterised in that：Described cornea plate
Interlayer fixture or posterior surface of cornea fixture materials selected from medical grade polymethylmethacrylacontinuous or
Medical rank titanium.
5. the artificial cornea according to any one of Claims 1 to 4, it is characterised in that：Described
Nanometer silver coating (3) nanoparticle average grain diameter be 1～100nm.
6. artificial cornea according to claim 5, it is characterised in that：Described Nano Silver
The average grain diameter of the nanoparticle of soil layer (3) is 5～50nm.
7. artificial cornea according to claim 6, it is characterised in that：Described Nano Silver
The average grain diameter of the nanoparticle of soil layer (3) is 20nm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610153120.4A CN106473837A (en) | 2016-03-17 | 2016-03-17 | Artificial cornea |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610153120.4A CN106473837A (en) | 2016-03-17 | 2016-03-17 | Artificial cornea |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106473837A true CN106473837A (en) | 2017-03-08 |
Family
ID=58238572
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610153120.4A Pending CN106473837A (en) | 2016-03-17 | 2016-03-17 | Artificial cornea |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106473837A (en) |
Citations (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4424753A1 (en) * | 1994-07-13 | 1996-01-18 | Fraunhofer Ges Forschung | Retina implant with array of polymer-sheathed conductive filaments on insulating substrate |
| CN2545994Y (en) * | 2002-04-28 | 2003-04-23 | 马伟建 | Polyvinyl alcohol copolymer aquagel soft artificial cornea |
| CN1660450A (en) * | 2004-02-27 | 2005-08-31 | 四川大学 | Artificial comea having biological activital activity and preparing method |
| CN1729026A (en) * | 2002-12-19 | 2006-02-01 | 诺瓦提斯公司 | Medical devices having antimicrobial coatings thereon |
| CN101001589A (en) * | 2004-06-01 | 2007-07-18 | 贝克顿迪肯森公司 | Ocular implant and methods for making and using same |
| CN201015616Y (en) * | 2006-11-16 | 2008-02-06 | 于好湧 | Artificial cornea device |
| CN201160919Y (en) * | 2008-03-05 | 2008-12-10 | 黄一飞 | Novel split type artificial cornea |
| CN101360523A (en) * | 2006-01-17 | 2009-02-04 | 创森德医疗设备公司 | Glaucoma treatment device |
| CN201939532U (en) * | 2010-12-23 | 2011-08-24 | 姚晓明 | Artificial cornea |
| CN103830021A (en) * | 2012-11-30 | 2014-06-04 | 复旦大学附属眼耳鼻喉科医院 | Keratoprosthesis and manufacturing method thereof |
| CN104522050A (en) * | 2015-01-07 | 2015-04-22 | 安徽瀚驰生物科技有限公司 | Composite bactericide of nano-silver and polyhexamethylene guanidine and processing technology of composite bactericide |
| CN204562464U (en) * | 2015-04-08 | 2015-08-19 | 河南宇宙人工晶状体研制有限公司 | With the artificial cornea of titanium metal film |
| CN105126155A (en) * | 2015-09-23 | 2015-12-09 | 江苏蓝湾生物科技有限公司 | Medical antibacterial swelling relieving material and preparation method of medical antibacterial swelling relieving material |
| CN205698126U (en) * | 2016-03-17 | 2016-11-23 | 黄一飞 | Artificial cornea |
-
2016
- 2016-03-17 CN CN201610153120.4A patent/CN106473837A/en active Pending
Patent Citations (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4424753A1 (en) * | 1994-07-13 | 1996-01-18 | Fraunhofer Ges Forschung | Retina implant with array of polymer-sheathed conductive filaments on insulating substrate |
| CN2545994Y (en) * | 2002-04-28 | 2003-04-23 | 马伟建 | Polyvinyl alcohol copolymer aquagel soft artificial cornea |
| CN1729026A (en) * | 2002-12-19 | 2006-02-01 | 诺瓦提斯公司 | Medical devices having antimicrobial coatings thereon |
| CN1660450A (en) * | 2004-02-27 | 2005-08-31 | 四川大学 | Artificial comea having biological activital activity and preparing method |
| CN101001589A (en) * | 2004-06-01 | 2007-07-18 | 贝克顿迪肯森公司 | Ocular implant and methods for making and using same |
| CN101360523A (en) * | 2006-01-17 | 2009-02-04 | 创森德医疗设备公司 | Glaucoma treatment device |
| CN201015616Y (en) * | 2006-11-16 | 2008-02-06 | 于好湧 | Artificial cornea device |
| CN201160919Y (en) * | 2008-03-05 | 2008-12-10 | 黄一飞 | Novel split type artificial cornea |
| CN201939532U (en) * | 2010-12-23 | 2011-08-24 | 姚晓明 | Artificial cornea |
| CN103830021A (en) * | 2012-11-30 | 2014-06-04 | 复旦大学附属眼耳鼻喉科医院 | Keratoprosthesis and manufacturing method thereof |
| CN104522050A (en) * | 2015-01-07 | 2015-04-22 | 安徽瀚驰生物科技有限公司 | Composite bactericide of nano-silver and polyhexamethylene guanidine and processing technology of composite bactericide |
| CN204562464U (en) * | 2015-04-08 | 2015-08-19 | 河南宇宙人工晶状体研制有限公司 | With the artificial cornea of titanium metal film |
| CN105126155A (en) * | 2015-09-23 | 2015-12-09 | 江苏蓝湾生物科技有限公司 | Medical antibacterial swelling relieving material and preparation method of medical antibacterial swelling relieving material |
| CN205698126U (en) * | 2016-03-17 | 2016-11-23 | 黄一飞 | Artificial cornea |
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|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20170308 |