CN1063974C - Wound bandage with polymer layer - Google Patents
Wound bandage with polymer layer Download PDFInfo
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- CN1063974C CN1063974C CN89100413A CN89100413A CN1063974C CN 1063974 C CN1063974 C CN 1063974C CN 89100413 A CN89100413 A CN 89100413A CN 89100413 A CN89100413 A CN 89100413A CN 1063974 C CN1063974 C CN 1063974C
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Abstract
The present invention discloses a bandage which can absorb transudate from wounds and transfer moisture to the air. The bandage is made of a layered product which contains a hydrophilic absorbent polymerized layer bound to a fabric layer. The method of applying the hydrophilic absorbent polymerized layer has the steps of injecting monomer solution to the fabric layer, and then solidifying the fabric layer to obtain the polymerized layer. When exposed on the transudate from a wound, the hydrophilic absorbent polymerized layer is automatically bound to the wound. A fabric layer is near the hydrophilic absorbent polymerized layer, and a pressure-sensitive adhesive is used for keeping the mutual contact between a high skin integral elastic membrane and the fabric layer on the opposite side.
Description
The application is that the series number of submitting on August 25th, 1986 is 06/899,575, and title is the part continuation application of " Wound dressings and manufacture method thereof " application.
The present invention is relevant with Wound dressings, and especially relevant with those binders that are used for covering wound, this class wound may ooze out a large amount of liquid when conventional therapy.
In the treatment process, the cutaneous lesion liquid body exudate of many types is normal phenomenons, the II and the III stage of this class wound such as ulcer, two degree and third degree burns, skin transplantation and skin donors position, the scratch in corium deep and scratch etc.Though conventional binder or Wound dressings are easy to absorb liquid, when they were used for above-mentioned damage, they were soaked into by the exudate in the open wound soon, therefore needed often more to change a bandage or binder.Frequent replacing can stimulate wound to bring misery also can increase medical expense to patient.Have a kind of Wound dressings when exudate on the open wound surface once occurring and they can being sponged, and the moisture that absorbs is transferred to [Backing layer this paper often calls it " surface far away " (the distal sur-face) of binder] in a kind of backing by binder by a speed of wishing, when covering binder on the wound, it is apart from wound surface farthest, here moisture content evaporates from the binder that covers wound, so be a kind of useful especially Wound covering material capable, because compare the time of this binder covering wound with conventional binder longer and do not change, so wound often is not subjected to changing the disturbance of binder, it is also less that patient is subjected to the misery that caused by wound.
Once doing multiple effort attempts to provide a kind of and can more effectively absorb from the Wound dressings of open wound effusion exudate.
At United States Patent (USP) 3,339, in 546, a kind of binder of being made up of impermeable layer was described, this band has a kind of adhesive phase that is superimposed together with impermeable layer.The adhesive agent layer of describing is the hydrocolloid material of a kind of water solublity or water-swellable and is dispersed in fully in a kind of elastic bandage of non-water-soluble viscosity.
United States Patent (USP) 3,972,328 also described a kind of Wound dressings of being made up of three parts, i.e. (1) intermediate layer of forming by a kind of toughness foamed materials of half-open hole, (2) a kind of fluid-tight lip-deep tough film in intermediate layer that is attached to, (3) a kind of pressure sensitive adhesive layer is placed on the another side in intermediate layer.The pressure-sensitive adhesion component is made up of the pressure-sensitive elastomeric material that contains certain water solublity or water-swellable hydrocolloid or hydrocolloid mixt, also contains a kind of viscosifier and a kind of plasticizer or solvent in addition.
Though adopt the hydrocolloid of water solublity or water-swellable is dispersed in the adhesive layer of Wound dressings, can absorb Wound exudate by hydrocolloid, but after hydrolyzed colloidal particle absorbs exudate, thereby the integrity that swelling has been destroyed adhesive film prematurely will take place in granule, make film forming breaking.
A kind of Wound dressings provided by the invention can absorb the Wound exudate of the remarkable quantity of overflowing and can not destroy the integrity of binder from a kind of open wound, in a kind of preferred design, this kind binder can be sent to the moisture content in the exudate surface far away of binder with the speed of a certain hope by binder, and in this atmosphere around being evaporated to, thereby prolonged service life of binder.Comprise a kind of braid layer (this paper is sometimes referred to as tissue layer) according to Wound dressings provided by the invention, the toughness continuous film of a kind of water wetted material of deposition on this layer is preferably hydrophilic absorbing agent polymer layer coated or be impregnated in the tissue layer.The pressure-sensitive adhesion material of one deck is adhered to the one side of tissue layer so that binder is fixed on one's body the patient, adhesion material be a kind of adhere to be added on the patient health skin and not with the material of open wound adhesion.For increasing the extra globality of binder, the surface far away of an outer cover formation binder is provided, when surface far away promptly was placed on binder on the wound, binder was apart from wound surface farthest.Under some situation of the present invention, the composition layer of binder preferably has porous, make the moisture content that contains in the body fluid can by desirable speed see through binder and at the binder back side or surface evaporation far away fall.
Last a kind of mode of the present invention is that hydrophilic absorbs the wound location that the Ji polymer layer directly adheres to patient.More particularly just provide a kind of Wound dressings of disposing wound body fluid, by sponging Wound exudate apace and, being subjected to maceration thereby reduce skin absorbing water gas shift in the liquid in atmosphere.This binder is formed attached to the stratiform thing that contains hydrophilic absorbing agent polymer layer on the tissue layer by one, the applying method of said hydrophilic absorbing agent polymer layer is that a kind of monomer solution is filled in the tissue layer, is solidified then and generates polymeric layer.Just stick to wound location automatically in case hydrophilic absorbing agent polymer layer contacts with Wound exudate, tissue layer is adjacent; Pressure-sensitive adhesive agent keeps cooperating contacting between elastic material membrane and the tissue layer with the skin height.The hydrophilic absorbent polymer layer of kind is that a kind of high skin is integrated elastomeric material antibacterial protecting film in addition, so that form the close contact skin with patient's wound location, and keep high skin to integrate elastic material membrane by pressure-sensitive adhesive agent encasing Wound dressings with contacting of opposite tissue layer.Every layer moist steam transfer rate wherein is enough to guarantee that the water vapour being absorbed in the Wound dressings fluid distributes, thereby reduces the dipping that new endothelium wound bed and wound circumference position are subjected to.
Fig. 1 is one section Wound dressings perspective view of an a kind of situation of explanation the present invention;
Fig. 2 is one section binder perspective view of another situation of explanation the present invention;
Fig. 3 is the sketch map that an explanation forms the compound composition of Wound dressings among Fig. 1 and 2;
Fig. 4 is the schematic diagram that an explanation is combined together to form two compounding ingredients Fig. 1 Wound dressings;
Fig. 5 is that an a kind of adhesion layer of usefulness combines two compounding ingredients the schematic diagram that forms Fig. 2 Wound dressings.
First kind of mode according to the present invention provides a kind of absorption Wound dressings that can be detained Wound exudate, and it is made up of a kind of stratiform thing that is made of following all layers.
(a) a kind of adhesion layer that can allow liquid pass through.When touching with patient skin generation pressure, the adhesion layer Wound dressings adheres on the skin, and need not the fixation of any outside;
(b) a kind of tissue layer and above-mentioned adhesion layer bonding is so that keep structural intergrity when Wound dressings is exposed to Wound exudate;
(c) be applied to a kind of hydrophilic absorbent polymeric layer in the tissue layer, hydrophilic absorbing agent polymer layer is by coated or be impregnated in the tissue layer, the fabric that generates has structural intergrity to keep the bonding of it and adhesion layer when Wound dressings is exposed in the Wound exudate, when on the skin that Wound dressings is placed on patient, said hydrophilic absorbing agent polymer layer can be drawn into the liquid of Wound exudate in the Wound dressings;
(d) at least one occlusion backing layer is selected from certain film, foamed materials, and the stratiform thing or the fabric of foamed materials one film, this backing layer is bonding with the fiber that stretches out by the adhesion layer of adjacency.
For various situations of the present invention, hydrophilic absorbing agent polymer layer is public, can be made by different polymer, and they can absorb 2-20 doubly to the exudate of weight own.This class hydrophilic material comprises sodium carboxymethyl cellulose, various polyacrylamides, polyacrylonitrile and acrylate copolymer, karaya and polysaccharide.A kind of nontoxic toughness film's layer 15 of being made up of crosslinked acrylate copolymer can prepare with purgation, with weight is 90-99.9% acrylic acid, wherein the carboxyl of 50-100% is that the multi-group crosslink agent of 0.1-10% and the light trigger that accounts for acrylic acid and cross-linking agent gross weight 0.1-5% carry out photopolymerization or irradiation polymerization (in blanket of nitrogen) by in alkali or the aqua ammonia and back with weight before polymerization, find 1984,1, the Canadian Patent No.1 of 24 issues, 160,984 these base polymers of relatively describing in detail are particularly suitables.At United States Patent(USP) Nos. 4,062,817 and 4,066,583 described the useful water wetted material of other, and useful polymer and their preparation method also are disclosed on common all patents, (United States Patent (USP) 4,167,464 and distribution in European patent on June 19th, 0,042,406,1985).Also can be with acrylic acid and acrylate unsubstituted or that replaced, particular content is referring to document description.
According to a preferable embodiment of this mode of the present invention, hydrophilic absorbent wherein is certain monomer solution to be applied or is impregnated in the fibrous layer solidified.In preferable enforcement, monomer solution can be single monomer solution, also can be the solution of several monomer mixtures, and they form a kind of copolymer when the cast monomer solution solidifies.
According to a preferable embodiment of this mode of the present invention, said adhesion layer is a kind of medicinal qualified porous pressure-sensitive acrylic compounds bur.According to a preferable embodiment of this mode of the present invention, tissue layer is to curl up combination from one group, curls up braiding or point in conjunction with a kind of polyester material composition of selecting in the polyester textile.
In a certain enforcement, the hydrophilic absorbent is a kind of crosslinked acrylic material, and according to the preferable embodiment of this mode of the present invention, the hydrophilic absorbing agent polymer is a kind of alginate or sodium carboxymethyl cellulose.
According to a preferable enforcement of first kind of mode of the present invention, provide a kind of occlusion formula Wound dressings that can be detained to live Wound exudate, it is to constitute by having following all layer a kind of layered article:
(a) adhesion layer that can allow liquid to see through, when with patient's skin crimping, adhesion layer sticks on the skin Wound dressings, need not other external stability measure;
(b) tissue layer that bonds of a kind of and above-mentioned adhesion layer, this layer keeps the integrity of structure when Wound dressings is exposed to Wound exudate;
(c) append to a kind of hydrophilic absorbing agent polymer layer in the tissue layer, the hydrophilic absorbing agent polymer is applied or is impregnated in the tissue layer by (1); (2) brush absorbent/fabric composite top surface so that most of fiber exposes; This impregnated fabric has structural integrity so that keep bonding with adhesion layer when Wound dressings is exposed to Wound exudate.When Wound dressings being placed on patient's compromised skin, hydrophilic absorbing agent polymer layer can sponge the liquid that is drawn in the binder from Wound exudate;
(d) adhesion layer on a kind of complex that appends to through brushing, the fiber that exposes adheres on the adhesion layer of adjacency.
(e) one deck occlusion backing layer at least should be from from certain film, and foamed materials is chosen in the multilamellar of foamed materials one film or the fabric, this backing layer via the adhesion layer of adjacency attached on the fiber that exposes.
According to the second way of the present invention, provide a kind of disposal wound fluidic Wound dressings, thereby by sponging Wound exudate apace also being dispersed into the etch of going in the atmosphere to have reduced to skin from the aqueous vapor that absorbs in the liquid.This binder is had following all layered articles and is formed by a kind of:
(a) a kind of adhesion layer that can allow liquid to see through, when pressing when touching with patient skin, this adhesion layer sticks on the skin Wound dressings and need not any external stability measure;
(b) the agglutinating tissue layer of a kind of and above-mentioned adhesion layer, when Wound dressings was exposed to Wound exudate, this layer maintained the globality of structure;
(c) a kind of hydrophilic absorbing agent polymer layer that is attached to tissue layer, hydrophilic absorbing agent polymer layer is added to or is impregnated in the tissue layer, the tissue layer that generates with structural intergrity when Wound dressings is exposed to exudate to keep the binding with adhesion layer, when Wound dressings being placed on patient's compromised skin, the hydrophilic absorbing agent polymer can sponge the liquid that is drawn into Wound dressings from Wound exudate;
(d) at least one backing layer, be selected from by a kind of film, foamed materials, one group of layered article that foamed materials-film constitutes or fabric, backing layer via the adjacency adhesion layer attached on the fiber that exposes, each of binder layer aqueous vapor transfer rate that has is enough to make the vapor evolution from being absorbed in the liquid in the Wound dressings to be fallen, and therefore reduced new endothelium wound bed and the etch of wound area on every side.
According to a preferable enforcement of this mode of the present invention, the hydrophilic absorbent of being addressed is solidified by monomer solution is applied or is impregnated in the tissue layer.The monomer material that adopts in first kind of mode of the present invention also can here adopt.According to the preferable embodiment of this mode of the present invention, adhesion layer is a porous pressure-sensitive acrylic adhesion material qualified on certain medicament.According to the preferable embodiment of this mode of the present invention, tissue layer is to be made of a kind of polyesters, and this polyester is selected from one group and curls up combination, curls up braiding or puts bonded polyester textile.According to the preferable embodiment of this mode of the present invention, the hydrophilic absorbent is certain crosslinked acrylic material.In another way, the hydrophilic absorbing agent polymer is a kind of alginate or sodium carboxymethyl cellulose, and the hydrophilic absorbing agent polymer is dispersed in the styrene butadiene styrene block copolymer (SBS) better in this enforcement.
Other embodiment according to the second way of the present invention, provide a kind of and can successfully dispose the fluidic Wound dressings of wound, because to the Wound exudate fast Absorption and make from being absorbed fluidic aqueous vapor and be dispersed in the atmosphere and go, thereby the etch of minimizing skin, binder is formed by having following all layer structures:
(a) a kind of adhesion layer that liquid is seen through need not the fixation of any outside pressing adhesion layer when touching that Wound dressings is sticked on the skin with patient skin;
(b) the bonded tissue layer of a kind of and above-mentioned adhesion layer when Wound dressings is exposed to Wound exudate, makes it to keep the integrity of its structure;
(c) a kind of hydrophilic absorbing agent polymer layer that appends to the above-mentioned fabrics layer, this hydrophilic absorbing agent polymer layer is applied in or is impregnated in the tissue layer, and the upper surface of absorbent/fibre composites of being generated of brush exposes fiber; Absorbing agent polymer layer after this curing promptly has the impregnated fabric of structural intergrity, the combination of maintenance and adhesion layer when Wound dressings exposes sub-Wound exudate, hydrophilic absorbing agent polymer layer can fall the Liquid Absorption that is drawn in the Wound dressings from Wound exudate when Wound dressings being put on patient's compromised skin;
(d) adhesion layer on a kind of composite absorber polymeric layer that appends to bristle, the fiber that exposes is bonded on the adhesion layer of adjacency.
(e) one deck backing layer at least, this layer is by one group of film, and foamed materials is chosen in foamed materials-membrane stratiform thing or the fabric, and the adhesion layer of this backing layer by adjacency is attached on the fiber that exposes.More than the transmission aqueous vapor speed that has of each layer be enough to that the moisture content of liquid distributes in the Wound dressings being absorbed in.Thereby reduced the etch around new endothelium wound bed and the wound.
The hydrophilic absorbent is by coating or is impregnated into monomer solution in the tissue layer and solidifies and make that according to a preferable embodiment of this mode of the present invention, the monomer that uses can be used for this mode in first kind of mode of the present invention; A preferable embodiment according to this mode of the present invention, adhesion layer is pharmaceutically qualified a kind of pressure-sensitive acrylic class adhesive agent: according to a preferable embodiment of this mode of the present invention, tissue layer is made up of a kind of polyester, this polyester is selected from a kind of combination of curling up, curl up-weave or point-bonded polyester material, according to a preferable enforcement of this mode of the present invention, the hydrophilic absorbent is a kind of crosslinked acrylic compounds.In other mode, the hydrophilic absorbing agent polymer is a kind of alginate or sodium carboxymethyl cellulose, and in this was implemented, the hydrophilic absorbing agent polymer can be distributed in the styrene butadiene styrene block copolymer (SBS) better.
Provide a kind of Wound dressings that constitutes by following all layers according to the third mode of the present invention:
(a) a kind of adhesion layer that allows liquid to see through, this adhesion layer can adhere to Wound dressings on the skin when touching with the patient skin pressure, need not any external stability measure;
(b) a kind of tissue layer that is bonded on the adhesion layer, this layer maintains structural integrity when Wound dressings is exposed to Wound exudate;
(c) a kind of hydrophilic absorbing agent polymer layer that is applied on the tissue layer, this layer is applied to or is impregnated in the tissue layer, the fabric with structural intergrity of generation.When Wound dressings is exposed to Wound exudate so that can be bonded on the adhesion layer.Above-mentioned hydrophilic absorbing agent polymer layer can fall the Liquid Absorption that is drawn on the Wound dressings when Wound dressings being placed on patient's compromised skin from Wound exudate;
(d) at least one covers the backing layer on (C) layer, and does not have pressure sensitive adhesive layer between two-layer;
(e) a kind of backing layer of die-cut periphery of two sides band adhesion layer is folded on skin adherence layer (a) second surface, also is folded on second surface of backing layer (d).
Provide a kind of occlusion formula Wound dressings in a kind of enforcement, it can be detained Wound exudate, and backing layer wherein (d) is the occlusion formula, and above-mentioned exudate is maintained at owing to absorbed from the liquid exudate of wound in the expansible backing layer (d).A kind of fluidic Wound dressings of wound of dealing carefully with also is provided in addition, also can goes by the fast Absorption Wound exudate, thereby alleviate the etch that skin is subjected to being dispersed in the atmosphere from the water vapour in the absorption liquid.The speed of the moist steam of the transmission that has of each layer here is enough to therefore alleviate new endothelium wound bed and the etch in wound district on every side distributing from the aqueous vapor that is absorbed in the wound dressing carrying liqs.
No matter which kind of situation, in a kind of preferred enforcement, the hydrophilic absorbent utilizes a kind of monomer solution coating or is impregnated in the tissue layer and is cured.In a kind of preferable enforcement, adhesion layer is a porous pressure-sensitive acrylic class binding agent qualified in a kind of pharmacy, and in other enforcement, tissue layer is made up of a kind of polyester thing, this polyester thing curls up from comprising-combination, curl up-weave or point-bonded polyester material in choose.In a kind of preferable enforcement, the hydrophilic absorbent is a kind of alginate or hydrophilic absorbent polymer layer sodium carboxymethyl cellulose material.
Provide a kind of according to last a kind of mode of the present invention and can deal carefully with the fluidic Wound dressings of wound, because it sponges Wound exudate apace also can be being dispersed in the atmosphere from the aqueous vapor that absorbs in the liquid, thereby alleviated etch to skin, this binder is formed by containing following all layer a kind of layered article: (a) a kind of height skin is integrated elastic antibacterial protecting film, and this film can closely contact and cover on the above-mentioned Wound dressings with patient's wound location skin;
(b) a kind of pressure sensitive adhesive layer keeps height skin integration elastica to contact with relative tissue layer;
(c) a kind of tissue layer;
(d) a kind of attached to the hydrophilic absorbing agent polymer layer on the tissue layer, by being injected tissue layer, a kind of monomer solution generates polymeric layer with after fixing.When said hydrophilic absorbing agent polymer layer is exposed to Wound exudate, can adhere to the wound district automatically.
More than every layer of water vapor transfer speed that has be enough to make vapor dispersion to be gone out from being absorbed in the wound dressing carrying liqs, thereby alleviated new endothelium wound bed and the etch in wound district on every side.
In the last mode of the present invention, provide a kind of crosslinked acrylic compounds material as the hydrophilic absorbent.Hydrophilic absorbing agent polymer layer be use with alternate manner of the present invention in the similar polymers used.In this last mode of the present invention, also be with a kind of pharmaceutically qualified porous pressure-sensitive acrylic class adhesive agent as adhesion layer, tissue layer can be by from curling up-combination, curl up-weave or point-bonded one group of polyester material in certain polyester thing of selecting form.
Description of drawings some mode of the present invention, the Wound dressings 10 that Fig. 1 represents is composed as follows, tissue layer 11 is superimposed and adhere to a broadside surfaces (its inside broadside surfaces) that covers it on a kind of adhesive, materials layer 12, another adhesion material layer 13 covers on another broadside surfaces (its outside broadside surfaces) at it, preferably adhesion layer 12 and 13 is expressed to tissue layer 11 and exposes in the fiber of outside, make adhesive agent be and the fiber ends bonding of from tissue layer 11, exposing.A kind of elastic hydrophilic material layer 15 be applied between adhesion layer 12 and 13 with tissue layer 11 among.Topped and be releasably secured on the broadside surfaces that adhesion layer 12 will expose (antiseized) layer that gets loose, so that between 10 storage lifves adhesion layer 12 is shielded, before being applied in binder 10 on the wound, just remove layers 16 at binder.Another overcoat 17 covers above the tissue layer 11 from the outside; by adhesion layer 13 on tissue layer 11; cover layer 17 not only provides a kind of structural intergrity of height for binder 10 as a kind of external protection; but also play a kind of effect of shielding, prevent to pollute that to enter binder inner and finally enter wound.
Be placed in the tissue layer 11 and the hydrophilic material ductile layers 15 between the adhesion layer 12,13 can be the nontoxic hydrophilic material of any toughness, doubly when the exudate of itself weight, still can keep the integrity of self even absorbed 2-20.This class hydrophilic material comprises sodium carboxymethyl cellulose, various polypropylene amines, polyacrylonitrile and acrylate copolymer, karaya and polysaccharide.A kind of nontoxic toughness rete 15 is made up of a kind of crosslinked acrylate copolymer, this polymer can be the acrylic acid of 90-99.9% by light or irradiation polymerization (in a kind of blanket of nitrogen) percentage by weight, 50-100% carboxyl has wherein been used in the hydroxide of alkali metal and ammonia before polymerization and mistake, adds the method preparation that the cross-linking agent total weight is the light trigger of 0.1-5% with polymer functional group's cross-linking agent of 0.1-10% with by acrylic acid.At the Canadian Patent No.1 of on January 24th, 1984 issue, this base polymer that relatively is described in detail in 160,984 is effective especially.Useful in addition hydrophilic material is a United States Patent(USP) Nos. 4,062,817 and 4,066,583 materials of describing are at common all patents, United States Patent (USP) 4,167,464 and European patent explanation 0,042,406, (distribution on June 9th, 1985) disclosed some useful polymer and their preparation method.Acrylic compounds or esters of acrylic acid, they be unsubstituted also can be various different replacements, can be adopted according to document description particularly.
For making binder transmit the ability of moisture and when measuring by ASTM step No.E96-80, under 50% relative humidity and 3H ℃ of condition, its MVTR value is per 24 hours 300-800 grams of an every square meter water, these all each layers that just require binder 10 are when measuring by ASTM step No.E96-80, their MVTR value is at least per 24 hours 300 grams of every square meter water under 50% relative humidity and 36 ℃ of conditions, and the MVTR value of cover layer 17 is preferably in 300-800 and restrains between the water.
Another kind of Wound dressings exudate processing system according to the present invention imagination is a kind of occlusion formula Wound dressings, can be detained the wound fluid body, in this enforcement, have at least one deck preferably cover layer 17 have lower MVTR value.By this design, liquid is absorbed in the fabric/hydrogel complexification thing of Wound dressings.
Wound dressings 20 shown in Figure 2 comprises a kind of tissue layer 21, and pressure-sensitive adhesion material layer 22 covers on the broadside surfaces of layer 21, and second adhesion material layer 23 covers on another broadside surfaces, and layer 22 is similar with 13 to the adhesion layer 12 of binder with 23.The adhesion layer 22 and 23 of binder 20 preferably is extruded in the fiber of stretching from 21 liang of broadside surfaces of tissue layer, thereby strengthened adhesion layer 22 and 23 and tissue layer 21 between the mechanical bond performance, a kind of toughness hydrophilic material layer be applied to the layer 22 and 23 between and the layer 21 among.A kind of protective layer that gets loose 25 cover on the broadside surfaces that adhesion layer 22 exposes in case when storing protection adhesion layer 22, before on the wound, throw off layer 25 binder 20 is topped.A kind of open-cell foam materials layer 26 is adhered on the outside broadside surfaces of adhesion layer 23, froth bed 26 has the shock-absorbing protecting effect to binder when being put into above the wound, reduces to be applied to external force on the binder 20 to the influence of wound.Optional a kind of cover layer 27 cover with adhere to above the layer 26, it not only gives binder 20 structural intergrities, prevents to pollute the inside that enters binder 20 but also can be used as a kind of screen layer.The layer 21,22,23,24,25 and 27 of binder 20 is 11,12,13,15,16 corresponding with 17 with the layer of binder 10 respectively on function, all layers available with binder 10 in the same material of homologue make.
If the speed that requires binder 20 to have every square metre of per 24 hours 300-800 gram water shifts the ability of moisture content, this speed is when measuring by ASTM step No.E96-80 method, under 50% relative humidity and 36 ℃ of conditions, the MVTR value of each layer must be not less than every square metre of per 24 hours 300 gram water, and have one deck at least, preferably the MVTR value of cover layer 27 is between 300-800 gram water.
At least the occlusion formula type of one deck of binder with low MVTR value also belongs to the binder with sponge layer or foamed materials/rete.
In the manufacturing of binder 10, tissue layer 11, the continuous flaky material of the adhesion layer 12 and the layer 16 that gets loose combines and constitutes the serialgram material of a complex " A ".For example a continuous flaky raw material that is bearing in the adhesion layer 12 on the layer 16 that gets loose is applied on the broadside surfaces of tissue layer 11, allow these three components between the pressure roller (not shown), pass through then, the fiber that stretches out from tissue layer 11 is expressed in the adhesion layer relative with it 12, make the combination between tissue layer 11 and the adhesion layer 12 firm, preserve the continuous film of complex " A " on the roller 30 standby.
As shown in Figure 3, can in tissue layer 11, form the water wetted material layer in the following manner, unclamp the film of the complex " A " that twists on the cylinder 30, it is passed through on roller 31 and 32, the tissue layer 11 of the complex A film of sending to is faced up, face the aerosol apparatus or the reservoir 34 that utilize nozzle 35 to spray hydrophilic film forming (film-producing) material below.Complex A with relief deposit hydrophilic filmogen passes through below doctor 37, and doctor 37 is expressed to the center of tissue layer 11 and the thickness that control generates hydrophilic film 15 to the hydrophilic film material.Be that a needs carries out simple drying according to the hydrophilic filmogen that adopts then, still need carry out polymeric concrete condition allows this complex by drying baker or polymerization chamber 38, if the hydrophilic film material is that those are at Canadian Patent No.1,160, the needs of describing on 894 carry out polymeric material, polymerization chamber 38 can contain electron beam or ultraviolet (UV) light source, makes hydrophilic film material polymerization reaction take place.Generate at last.By tissue layer 11, be deposited on the hydrophilic membrane 15 in the tissue layer 11, the continuous film of the complex " B " that the adhesion layer 12 and the layer 16 that can get loose constitute is around depositing to roller 39.
The continuous film of adhesion layer 13 and cover layer 17 have been combined together to form the continuous film of a kind of complex " c " that contains adhesion layer 13 and cover layer 17 by arbitrary suitable method.For example a kind of seriality membrane cover of adhesion layer 13 on cover layer 17, make then its between the pressure roll (not shown) by generating this complex, the continuous film of complex c is standby around storing to another cylinder 40.
As shown in Figure 4, the adhesion layer 13 of complex c is face-to-face with the tissue layer 11 of complex B, utilize this adhesion layer to combine complex B and complex C, film after making complex B then and C combining passes through in the middle of cylinder 41 and 42, the fiber that tissue layer 11 is stretched out is expressed in the adhesion layer 13, both is bonded together has promptly finished the manufacturing of Wound dressings 10.Technology in addition is exactly that this complexes membrane is sheared and encapsulated by the size of binder requirement.Also can be on roller bearing 44 in the middle of this continuous film of binder 10, of course, if desired the manufacturing process of binder 10 can be designed to a kind of continued operation.
In addition, also can go up generate a kind of complex B ' of remodeling to the adhesion layer composite membrane B that is added to, allow then adhere to supine complex B ' and generate complete binder by pressure roll with cover layer 17.
In this technology, when adhere to superimposed before, need be the upper surface of complex B (fabric/hydrogel) bristle to guarantee the having fiber of sufficient amount to stretch out, so that strong bonded between adhesion layer and tissue layer.This point is crucial for the structural intergrity of remodeling complex B '.
In addition, also can adhesion layer D and foamed materials or foamed materials/membrane complex E carry out superimposed before, earlier adhesion layer D is bonded to the complex B ' that complex B goes up a kind of remodeling of formation, will has the remodeling complex B ' that adhesive face makes progress then and form complete binder by pressure roll with complex E.
In this technology, adhere to superimposed before, want abundant to guarantee the fiber number that exposes the upper surface of complex B (fabric/hydrogel) bristle earlier, make to combine firmly between adhesion layer and the tissue layer, this point is crucial for the structural intergrity of the complex B ' that retrofits.
Wound dressings preferably has permeability to oxygen, when binder is soaked by Wound exudate, when it provides the performance of delivery of oxygen to measure as operating No.D3985-81 by ASTM, is under the 20-55% condition at 25 ℃ with relative humidity, be at least every square metre of per 24 hours 2000 milliliters of oxygen, be preferably 5000 milliliters.
This application is incorporated into own forces in the United States Patent (USP) of publishing in 1985.6.19 day 4,167,464 and European patent specification 0042,406,
Below all examples the present invention will be described:
Example 1:
A kind of characteristic of the adhesive agent one fabric binder course as end liner is as follows:
MDD129 (Semex), superimposed the going up at Reemy2214 (Reemy company) of a kind of porous polyacrylate generates a kind of complex.
On the fabric side of above-mentioned complex, utilize the UV hardening with radiation to generate the heavy 1.2g/ft of thick 0.075mm sodium acrylate/acrylic acid monomer latex coated
2Coating.The thickness of Wound dressings of the present invention and coating weight parameter are preferably in about 0.01-0.5mm and 1.0-5.0g/ft
2Between.When Wound dressings was exposed to Wound exudate, the ground of the fabric of generation energy structural integrity was bonded on the adhesion layer.When on the compromised skin that Wound dressings is placed on patient, the liquid polymer can sponge from the Wound exudate extracting to Wound dressings.
The example II
Polyacrylate adhesive agent I-780 (Aevery) with climax moisture migration speed is appended on the polymerization object plane of routine I product, again a kind of liquid can not see through enter atmospheric polyethylene occlusion film adhere to adhesive agent above.
Example III-V
Except that with the occlusion film in the following material substitution example II, other follow the step of routine II:
The film polrvinyl chloride
The foamed materials Vestolit
Foam-film has the polychlorostyrene second of polyethylene coverlay
The alkene foam plastics
The foamed materials polyethylene foams
The film polyvinylidene chloride
The example VI
Follow the operating procedure of routine I, but after polymeric layer solidifies, with the surperficial bristle of cured polymer.
Example VII-X
Follow the operating procedure of routine III-V, but the bristle polymer-backed that use-case VI method makes replaces the occlusion lining adhered on the product of routine I, because the uneven structural intergrity that obtains of bristle fabric face is better.
Example X IV
A kind of adhesive agent one fabric binder course as end liner has following characteristic:
MDO129 (Semcx) is folded into Reemay2414 curls up (Reemay, Inc on the bonded polyester thing.), this complex is sold with CM5383-02 (Semex) trade name.
A kind of alginic acid calcium salt film is coated on the fabric side of complex, and the generation coating layer thickness is 0.2mm, and coating weight is 3g/ft
2
Example X V
Replace alginate in the routine X IV and prepare a kind of analog with the sodium carboxymethyl cellulose that is dispersed among the Shells Kraton SBS G160.
Example X III-X V
In routine I and VIII, in X IV and the X V, not with the occlusion lining, be coated with the fabric that is wrapping polymer and can be made into a kind of binder that can deal carefully with wound liquid, because it can promptly absorb Wound exudate and can be the water gas shift in the absorption liquid in atmosphere, thereby reduced etch to skin.
The characteristic of this mode backing layer of the present invention is a kind of film, foamed materials, the layered article or the fabric of foamed materials one film.Therefore the migration rate of the moist steam that they have can reduce the etch that is subjected to around new endothelium wound bed and the wound with going out from being absorbed in the Wound dressings vapor evolution of liquid completely,
For example, be added on the aforesaid complex a kind of netted polyurethane foam plastic backings is stacked, this layer has the high moisture migration rate thin film of polyurethane film or polyether block acid imide or polyesters.
The example XX
A kind of adhesive agent one fabric binder course as end liner has following characteristic:
MDO129 (Semex), a kind of porous polyacrylic acid (ester) adhesive agent is folded into Reemay2214, and (Reemay Inc.) goes up a kind of complex of formation, and this complex is with CM5383-02 (Semex) commodity selling.
The fabric side of poly-sulfonamides coated to complex, by the UV hardening with radiation, the generation coating layer thickness is 0.5mm, and coating heavily is 5g/ft
2The fabric that generates have structural intergrity when keeping that Wound dressings is exposed to Wound exudate with the engaging of adhesive agent, in addition, when binder being positioned on patient's compromised skin, polymer can fall the Liquid Absorption that is drawn into the binder from Wound exudate.
Example X XI
A kind of Wound dressings that can properly dispose wound liquid is dispersed in the atmosphere and goes by the fast Absorption Wound exudate and absorbing aqueous vapor in the liquid, thereby reduced the etch that skin is subjected to.Need not directly be put into by adhesive agent on the routine I product polymerization object plane is a kind ofly to allow liquid to see through and enter a kind of backing layer that goes in the atmosphere.All there are the laying of adhesive agent, 1522 two-sided polyethylene tapes (3M) to be added in the skin adherence agent of routine I product, on another surface of the backing layer that also is added to simultaneously, obtain a kind of emission rate faster a kind of two sides of cross cutting periphery.
Example X XII-XX III
Adopt a kind of polyester film and netted polyurethane foam material to repeat the technology of routine X XI respectively as backing layer,
Example XX IV
This example is used for illustrating a kind of Wound dressings that can deal carefully with wound liquid, is dispersed in the atmosphere and goes by the fast Absorption Wound exudate and sponging aqueous vapor in the liquid, and reduce etch to skin.This binder comprises:
A kind of high skin is integrated toughness antibacterial protecting film, is a kind of polyurethane film;
A kind of pressure-sensitive adhesive agent is positioned at protecting film and fabric, between the MDO129 (Semex);
A kind of Reemay curls up the tissue layer in conjunction with polyesters; With
A kind of hydrophilic absorbent polymer layer that appends to tissue layer is a kind of polymerization (sodium acrylate.) the moist vapor migration speed that generates product is enough to that the water vapour of liquid distributes in the binder absorbing, thereby reduced the etch around new endothelium wound bed and the wound,
Example XX V
Replace the polymerization (sodium acrylate) in the routine XX VI and make similar results with calcium alginate.
Example XX VI
Replace the polymerization (sodium acrylate) in the routine XX IV to produce a kind of similar product with the carboxymethyl cellulose that is distributed in the s-B-S.
Example XX VII-XX IX
Replace the polyurethane film backing layer in routine XX IV-XX VI to produce similar product with a kind of polyether block acid imide film.
The example XXX
The some drugs of using to patient can be placed in the binder, for example can medicinal Chorhexidine be distributed in the polymeric layer, and it just is diffused into wound location when using this Wound dressings.
Claims (10)
1. comprise Wound dressings with following all layer stratiform thing:
(a) a kind of adhesion layer that allows liquid to pass through, when this adhesion layer and patient skin are pressed when touching, Wound dressings can adhere on the skin and need not to adhere on the wound;
(b) a kind of tissue layer that combines with adhesion layer, when Wound dressings was exposed to Wound exudate, it can keep structural integrity;
(c) a kind of hydrophilic adsorpting polymerization layer, it comprises the hydrophilic adsorpting polymerization thing that impregnated in the tissue layer, when Wound dressings is exposed to Wound exudate, the gained fabric still keeps and the bonded integrity of adhesion layer, said hydrophilic absorbent polymeric layer can be when Wound dressings be placed on patient's compromised skin, sponges from Wound exudate and is drawn into liquid the binder;
(d) at least one backing layer is selected from film, foam, and the stratiform thing or the fabric of foam-film, and via adjacent layer backing layer is attached on the described fabric.
2. the Wound dressings of claim 1, wherein hydrophilic adsorpting polymerization thing is solidified in addition by a kind of monomer solution being impregnated into after the tissue layer.
3. claim 1 or 2 Wound dressings, wherein said adhesion layer is medicinal porous pressure-sensitive acrylic class adhesive agent.
4. claim 1 or 3 Wound dressings, wherein said tissue layer is made up of polyester, and this polyester is selected from and curls up combination, curls up braiding or puts bonded polyester.
5. the Wound dressings of claim 2, wherein said hydrophilic adsorpting polymerization thing is a kind of crosslinked acrylic material.
6. the Wound dressings of claim 1, wherein said hydrophilic adsorpting polymerization thing is a polyacrylate, alginate or sodium carboxymethyl cellulose.
7. the Wound dressings of aforementioned arbitrary claim, wherein the top of gained absorption/tissue layer has many surfaces can nappy fabric, and described backing layer is attached on the above-mentioned nap fabric by contiguous adhesion layer.
8. the Wound dressings of aforementioned arbitrary claim, wherein every layer all has enough moist steam migration velocities, so that will go out from the vapor evolution of the liquid that absorbs in the described binder.
9. the Wound dressings of aforementioned arbitrary claim, it also can comprise the cross cutting periphery end liner layer of a two sides band adhesive agent, it is folded on the adhesion layer (a), also is folded on the backing layer (d).
10. the wound bag pore area of aforementioned arbitrary claim, wherein backing layer comprises and the elastic bacterial layer barrier film of skin highly compatible, it makes skin combine and cover described Wound dressings closely with patient's wound district.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN89100413A CN1063974C (en) | 1989-01-25 | 1989-01-25 | Wound bandage with polymer layer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN89100413A CN1063974C (en) | 1989-01-25 | 1989-01-25 | Wound bandage with polymer layer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1044405A CN1044405A (en) | 1990-08-08 |
| CN1063974C true CN1063974C (en) | 2001-04-04 |
Family
ID=4853846
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN89100413A Expired - Lifetime CN1063974C (en) | 1989-01-25 | 1989-01-25 | Wound bandage with polymer layer |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1063974C (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1047318C (en) * | 1992-09-04 | 1999-12-15 | 刘喜生 | Method for preparation of wound surface overlaying material |
| DK1164986T3 (en) * | 1999-04-02 | 2007-01-08 | Kci Licensing Inc | Vacuum-assisted closure system with heating and cooling measures |
| CN101254145B (en) * | 2007-02-28 | 2011-03-23 | 周长忠 | Multilayer shallow layer trauma special hydrophilic dressing |
| TWI504420B (en) * | 2011-11-29 | 2015-10-21 | Kang Na Hsiung Entpr Co Ltd | Hydrogel Substrate and Manufacturing Method and Hydrogel Dressing |
| CN104652125B (en) * | 2013-11-25 | 2018-12-11 | 3M创新有限公司 | Fabric construction and its manufacturing method |
| JP2020203232A (en) * | 2019-06-14 | 2020-12-24 | セイコーエプソン株式会社 | Liquid absorption body, liquid absorption device, and liquid treatment apparatus |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3632416A (en) * | 1967-10-27 | 1972-01-04 | Nat Patent Dev Corp | Fibrous textile materials impregnated with hydroxyalkyl methacrylate casting syrups |
| US4248736A (en) * | 1978-01-18 | 1981-02-03 | Kuraray Co., Ltd. | Fibrous adsorbent for hemoperfusion |
| US4538603A (en) * | 1982-04-22 | 1985-09-03 | E. R. Squibb & Sons, Inc. | Dressings, granules, and their use in treating wounds |
-
1989
- 1989-01-25 CN CN89100413A patent/CN1063974C/en not_active Expired - Lifetime
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3632416A (en) * | 1967-10-27 | 1972-01-04 | Nat Patent Dev Corp | Fibrous textile materials impregnated with hydroxyalkyl methacrylate casting syrups |
| US4248736A (en) * | 1978-01-18 | 1981-02-03 | Kuraray Co., Ltd. | Fibrous adsorbent for hemoperfusion |
| US4538603A (en) * | 1982-04-22 | 1985-09-03 | E. R. Squibb & Sons, Inc. | Dressings, granules, and their use in treating wounds |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1044405A (en) | 1990-08-08 |
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