CN106362198A - Macromolecular biological material - Google Patents
Macromolecular biological material Download PDFInfo
- Publication number
- CN106362198A CN106362198A CN201610747303.9A CN201610747303A CN106362198A CN 106362198 A CN106362198 A CN 106362198A CN 201610747303 A CN201610747303 A CN 201610747303A CN 106362198 A CN106362198 A CN 106362198A
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- CN
- China
- Prior art keywords
- parts
- biological material
- weight
- bonding
- macromolecular biological
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/08—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/0005—Ingredients of undetermined constitution or reaction products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/10—Polypeptides; Proteins
- A61L24/104—Gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/10—Polypeptides; Proteins
- A61L24/108—Specific proteins or polypeptides not covered by groups A61L24/102 - A61L24/106
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- Health & Medical Sciences (AREA)
- Surgery (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention relates to a macromolecular biological material. The macromolecular biological material is prepared from the following raw materials in parts by weight: 22-29 parts of butyl cyanoacrylate, 4-6 parts of sodium alginate, 2-6 parts of propylene glycol, 7-10 parts of pectin, 2-5 parts of sodium alginate, and 5-7 parts of gelatin. The product provided by the invention is moderate in curing speed, high in bonding strength, and small in heat release amount during bonding, a bonded film is good in tenacity, the irritation to skin is small, the macromolecular biological material has high-intensity rapid bonding effect for various wounds and surgical incisions, and no scars are left after bonding.
Description
Technical field
The present invention relates to medical bio new material technology field, specifically a kind of polymeric biomaterial.
Background technology
Medical glue is that instead of the emerging curable product of suture needle, and the main component of medical glue is a- cyano group acrylic acid
Ester, it is the fastest in the polymerization speed of bio-tissue.In the presence of medical glue anion in wound surface blood and tissue fluid, energy
Rapid polymerization film-forming simultaneously inlays, with wound surface, the apposition that closely can firmly hold wound, and glued membrane can stop blood cell,
Platelet is passed through, and under the collective effect of thrombin and Fibrinogen, the thin vessels of wound closure fracture can effectively stop blooding,
Glued membrane will be organized and antibacterial isolation simultaneously, also have infection and the effect of protection wound surface.Ether chain in polymer only also has
Pain acts on, therefore medical glue have viscous and, hemostasis, pain relieving, antiinflammatory, shield wound, promote the synthesis work(such as healing.
Content of the invention
The technical problem to be solved is to provide a kind of polymeric biomaterial.
The technical scheme is that a kind of polymeric biomaterial, wrap by weight
Include:
The invention has the beneficial effects as follows: product curing rate of the present invention is moderate, and bonding strength is high, and during bonding, heat release is low, glues
Connect film toughness good, little to skin irritation, to various wounds, operative incision, there is the effect of high intensity quick-binding, after solidification
No cicatrix.
On the basis of technique scheme, the present invention can also do following improvement.
Preferably, include by weight:
Preferably, also include the soybean protein powder of 5～12 weight portions.
Preferably, include by weight:
Include by weight:
Preferably, also include the described Aloe powder of 1～10 weight portion.
Specific embodiment
Embodiment 1
A kind of polymeric biomaterial, includes by weight: 25 parts of Tisuacryl, 6 parts of sodium alginate, the third two
5 parts of alcohol, 10 parts of pectin and 7 parts of gelatin.
Each raw material is sequentially added in reactor, and is warming up to 65-85 DEG C, stir 10 minutes, be sufficiently mixed uniformly.
Embodiment 2
A kind of polymeric biomaterial, includes by weight: 25 parts of Tisuacryl, 6 parts of sodium alginate, the third two
5 parts of alcohol, 10 parts of pectin, 7 parts of gelatin and 6 parts of soybean protein powder.
Each raw material is sequentially added in reactor, and is warming up to 65-85 DEG C, stir 10 minutes, be sufficiently mixed uniformly.
Embodiment 3
A kind of polymeric biomaterial, includes by weight: 35 parts of Tisuacryl, 5.5 parts of sodium alginate, third
5 parts of glycol, 8 parts of pectin, 7 parts of gelatin and 6 parts of Aloe powder.
Each raw material is sequentially added in reactor, and is warming up to 65-85 DEG C, stir 10 minutes, be sufficiently mixed uniformly.
Embodiment 4
A kind of polymeric biomaterial, includes by weight: 35 parts of Tisuacryl, 5.5 parts of sodium alginate, third
5 parts of glycol, 8 parts of pectin, 7 parts of gelatin and 7 parts of soybean protein powder.
Each raw material is sequentially added in reactor, and is warming up to 65-85 DEG C, stir 10 minutes, be sufficiently mixed uniformly.
To the biomaterial being obtained in embodiment 1-4 in the present invention, testing result is shown in Table down:
| Expansion rate of water absorption (%) | Fracture strength (mpa) | |
| Embodiment 1 | 268 | 0.9 |
| Embodiment 2 | 275 | 0.84 |
| Embodiment 3 | 246 | 0.8 |
| Embodiment 4 | 232 | 0.79 |
Product curing rate of the present invention is moderate, and bonding strength is high, and during bonding, heat release is low, and adhering film good toughness, to skin
Zest is little, has the effect of high intensity quick-binding to various wounds, operative incision, no cicatrix after solidification.
Although embodiments of the invention have been shown and described above it is to be understood that above-described embodiment is example
Property it is impossible to be interpreted as limitation of the present invention, those of ordinary skill in the art within the scope of the invention can be to above-mentioned
Embodiment is changed, changes, replacing and modification.
Claims (5)
1. a kind of polymeric biomaterial is it is characterised in that include by weight:
2. according to claim 1 a kind of polymeric biomaterial it is characterised in that including by weight:
3. according to claim 1 a kind of polymeric biomaterial it is characterised in that also including the big of 5～12 weight portions
Soybean protein powder.
4. according to claim 3 a kind of polymeric biomaterial it is characterised in that including by weight:
5. according to claim 1 a kind of polymeric biomaterial it is characterised in that also including the Aloe of 1～10 weight portion
Powder.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610747303.9A CN106362198A (en) | 2016-08-29 | 2016-08-29 | Macromolecular biological material |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610747303.9A CN106362198A (en) | 2016-08-29 | 2016-08-29 | Macromolecular biological material |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106362198A true CN106362198A (en) | 2017-02-01 |
Family
ID=57903341
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610747303.9A Pending CN106362198A (en) | 2016-08-29 | 2016-08-29 | Macromolecular biological material |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106362198A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107412846A (en) * | 2017-07-27 | 2017-12-01 | 苏州凌科特新材料有限公司 | A kind of composite antibacterial medical adhesive and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102895700A (en) * | 2012-09-04 | 2013-01-30 | 青岛保利康新材料有限公司 | Medical wound repair polymer biomaterial |
| CN104436286A (en) * | 2014-12-17 | 2015-03-25 | 安徽省健源医疗器械设备有限公司 | Pectin hemostatic gauze and preparation method thereof |
| CN105617452A (en) * | 2015-12-31 | 2016-06-01 | 佛山铭乾科技有限公司 | Novel medical biological material |
| CN105770980A (en) * | 2016-04-07 | 2016-07-20 | 苏州蔻美新材料有限公司 | Medical adhesive and preparation method thereof |
-
2016
- 2016-08-29 CN CN201610747303.9A patent/CN106362198A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102895700A (en) * | 2012-09-04 | 2013-01-30 | 青岛保利康新材料有限公司 | Medical wound repair polymer biomaterial |
| CN104436286A (en) * | 2014-12-17 | 2015-03-25 | 安徽省健源医疗器械设备有限公司 | Pectin hemostatic gauze and preparation method thereof |
| CN105617452A (en) * | 2015-12-31 | 2016-06-01 | 佛山铭乾科技有限公司 | Novel medical biological material |
| CN105770980A (en) * | 2016-04-07 | 2016-07-20 | 苏州蔻美新材料有限公司 | Medical adhesive and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 方亮: "《药剂学 第3版》", 31 March 2016, 中国医药科技出版社 * |
| 薛巍主编: "《生物医用水凝胶》", 31 December 2012, 暨南大学出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107412846A (en) * | 2017-07-27 | 2017-12-01 | 苏州凌科特新材料有限公司 | A kind of composite antibacterial medical adhesive and preparation method thereof |
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| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170201 |
|
| RJ01 | Rejection of invention patent application after publication |