CN106362180B - A kind of hot air sterilization indicant and preparation method thereof - Google Patents
A kind of hot air sterilization indicant and preparation method thereof Download PDFInfo
- Publication number
- CN106362180B CN106362180B CN201610737826.5A CN201610737826A CN106362180B CN 106362180 B CN106362180 B CN 106362180B CN 201610737826 A CN201610737826 A CN 201610737826A CN 106362180 B CN106362180 B CN 106362180B
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- hot air
- air sterilization
- tablet
- indicant
- water suction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/26—Accessories or devices or components used for biocidal treatment
- A61L2/28—Devices for testing the effectiveness or completeness of sterilisation, e.g. indicators which change colour
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
- A61L2/04—Heat
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N31/00—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods
- G01N31/22—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using chemical indicators
- G01N31/226—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using chemical indicators for investigating the degree of sterilisation
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a kind of hot air sterilization indicants and preparation method thereof, belong to hot air sterilization instruction field.The weight of the active constituent of hot air sterilization indicant forms are as follows: 1-10 parts of methylamino anthraquinone, 1-10 parts of polyvinylpyrrolidone, 50~90 parts of mannitol；Above-mentioned active constituent is placed in uniform stirring in batch mixer and forms combination material, is then fed into tablet press machine and is carried out tabletting and form sterilizing instruction tablet.It will indicate that tablet is fitted into the device with water suction core to seal to get hot air sterilization indicant.Hot air sterilization indicant provided by the invention is exposed under 160 DEG C of -180 DEG C of dry heat conditions, and instruction tablet melts, and then is crawled along water suction core, can judge whether sterilizing is qualified by the distance creeped.
Description
Technical field
The present invention relates to a kind of hot air sterilization indicants and preparation method thereof, belong to hot air sterilization indicator field.
Background technique
The effective sterilizing of medical treatment packet is the key link for avoiding sufferer postoperative infection.Currently used sterilization method is high pressure
Steam sterilizing, but for it is some it is thermo-labile, moisture-proof, steam or gas cannot not penetrate article, such as glass, grease, pulvis,
Common sterilizing methods are hot air sterilization.Common hot air sterilization indicant is chemical change monitoring card on the market at present, that is, is reached
Certain temperature and time, indicant occur chemical reaction and with color changes, to judge whether article reaches sterilizing and require.
But the shortcomings that this kind of indicant is: when 1 long-time is exposed in air, indicant color can deepen, and influence result interpretation；2
It is needed compared with contrastive colours after sterilizing, as contrastive colours span is little, it will be difficult to carry out interpretation.In summary consider, there is an urgent need to
A kind of indicant colour stable, the hot air sterilization indicant for being easy interpretation.
Summary of the invention
In order to overcome the deficiencies in the prior art, the present invention provides a kind of formulation stable, and visual result is accurately done
Heat sterilization indicant and preparation method thereof is applied to monitoring hot air sterilization result.
In order to solve the above technical problems, the present invention uses the monitoring technology of physical change, technical solution are as follows:
The mass fraction of a kind of hot air sterilization indicant, the hot air sterilization indicant, component and each component is distinguished
Are as follows: 1-10 parts of methylamino anthraquinone, 1-10 parts of polyvinylpyrrolidone, 50~90 parts of mannitol.
It is described the preparation method is as follows:
By methylamino anthraquinone, polyvinylpyrrolidone and mannitol, ingredient is placed into uniform stirring in batch mixer according to the ratio
Material is combined in formation in 25-40 minutes, and the combination material is sent into tablet press machine and carries out tabletting and forms sterilizing instruction tablet.
It will indicate that tablet is fitted into the device with water suction core later to seal to get hot air sterilization indicant.
The instruction tablet is cylinder, and diameter 3-8mm is highly 1-4mm.
The device with water suction core is made of water suction core 3, aluminum foil and adhesive tape 4, PP film 2, synthesis paper label 1.
Synthesis paper label is located above PP film, and synthesis paper label, PP film, aluminum foil and adhesive tape are from top to bottom set gradually.Absorb water core
Middle position between PP film and aluminum foil and adhesive tape.
The shape with blotting paper core apparatus is rectangle, a length of 50-100mm, width 20-40mm.
The instruction tablet 5 is placed between PP film and aluminum foil and adhesive tape, and with water suction core end thereof contacts.
Compared with the existing technology, beneficial effects of the present invention: hot air sterilization indicant provided by the invention is exposed to xeothermic
After sterilising conditions, instruction tablet melts, and crawls along water suction core, indicates that sterilizing is by the distance creeped
No qualification.Due to being physical change, that there is no color changes is unstable, is difficult to the phenomenon that judging.Formulation stable, visual result,
Accurately, the needs that can satisfy hospital hot air sterilization reach the standard of hospital's sterilizing application.
Detailed description of the invention
Fig. 1 is the structure drawing of device with water suction core.
Specific embodiment
Below with reference to embodiment, the present invention will be further explained.
Embodiment 1:
A kind of hot air sterilization indicant, the mass fraction of component and each component are as follows:
3 parts of methylamino anthraquinone, 5 parts of polyvinylpyrrolidone, 90 parts of mannitol
After above component uniform stirring 25-40 minutes, it is sent into tablet press machine and carries out tabletting.Tablet is packed into band water suction afterwards
Sealing is in the device of core to get hot air sterilization indicant.
Embodiment 2:
A kind of hot air sterilization indicant, the mass fraction of component and each component are as follows:
1 part of methylamino anthraquinone, 10 parts of polyvinylpyrrolidone, 90 parts of mannitol
After above component uniform stirring 25-40 minutes, it is sent into tablet press machine and carries out tabletting.Tablet is packed into band water suction afterwards
Sealing is in the device of core to get hot air sterilization indicant.
Embodiment 3:
A kind of hot air sterilization indicant, the mass fraction of component and each component are as follows:
10 parts of methylamino anthraquinone, 10 parts of polyvinylpyrrolidone, 50 parts of mannitol
After above component uniform stirring 25-40 minutes, it is sent into tablet press machine and carries out tabletting.Tablet is packed into band water suction afterwards
Sealing is in the device of core to get hot air sterilization indicant.
When monitoring, above-mentioned hot air sterilization indicant, biological indicator and article subject to sterilization are placed in packaging material together,
And it is packed using Closed process.It is put in hot air sterilizer and sterilizes after packaging.Sterilising temp is 160 DEG C, sterilizing
Time is 2h.Above-mentioned package is taken out after sterilizing, sterilizing indicant climbs completely entire water suction core, and the sterile life of biological indicator
It is long, it was demonstrated that the article in this packet has passed through sterilizing.Indicant after sterilizing is placed in and is placed 30 days at room temperature, indicant color
Without any significant change.
It was found from above-mentioned test result: hot air sterilization indicant formulation stable, it is visual result, accurate, be easy to store and
Interpretation.
The above is only a preferred embodiment of the present invention, it should be pointed out that: for the ordinary skill people of the art
For member, various improvements and modifications may be made without departing from the principle of the present invention, these improvements and modifications are also answered
It is considered as protection scope of the present invention.
Claims (4)
1. a kind of hot air sterilization indicant, it is characterised in that: the hot air sterilization indicant, the quality of component and each component
Number is respectively as follows: 1-10 parts of methylamino anthraquinone, 1-10 parts of polyvinylpyrrolidone, 50~90 parts of mannitol.
2. the preparation method of hot air sterilization indicant according to claim 1, which comprises the steps of:
By methylamino anthraquinone, polyvinylpyrrolidone and mannitol, ingredient is placed into uniform stirring 25-40 in batch mixer according to the ratio
Minute forms combination material, and the combination material is sent into tablet press machine and carries out tabletting and forms the instruction tablet that sterilizes；Later
It will indicate that tablet is fitted into the device with water suction core to seal to get hot air sterilization indicant；
The device with water suction core is made of water suction core, aluminum foil and adhesive tape, PP film, synthetic paper label；The finger
Show that tablet is placed between PP film and aluminum foil and adhesive tape, and with water suction core end thereof contacts.
3. the preparation method of hot air sterilization indicant according to claim 2, which is characterized in that the instruction tablet is
Cylinder, diameter 3-8mm are highly 1-4mm.
4. the preparation method of hot air sterilization indicant according to claim 2, which is characterized in that the band water suction core
Device shape be rectangle, a length of 50-100mm, width 20-40mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610737826.5A CN106362180B (en) | 2016-08-29 | 2016-08-29 | A kind of hot air sterilization indicant and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610737826.5A CN106362180B (en) | 2016-08-29 | 2016-08-29 | A kind of hot air sterilization indicant and preparation method thereof |
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| Publication Number | Publication Date |
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| CN106362180A CN106362180A (en) | 2017-02-01 |
| CN106362180B true CN106362180B (en) | 2019-08-06 |
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| CN201610737826.5A Active CN106362180B (en) | 2016-08-29 | 2016-08-29 | A kind of hot air sterilization indicant and preparation method thereof |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10512286B2 (en) * | 2017-10-19 | 2019-12-24 | Rai Strategic Holdings, Inc. | Colorimetric aerosol and gas detection for aerosol delivery device |
| CN109395133A (en) * | 2018-09-20 | 2019-03-01 | 南京巨鲨显示科技有限公司 | A kind of pressuresteam sterilization indicant and preparation method thereof |
| CN111138903A (en) * | 2019-12-31 | 2020-05-12 | 南京巨鲨显示科技有限公司 | Dry heat sterilization indicating ink, preparation method and dry heat sterilization indicator |
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| JPH0383685A (en) * | 1989-08-29 | 1991-04-09 | Konica Corp | Method for forming thermal transfer image |
| CN102061329A (en) * | 2010-11-29 | 2011-05-18 | 山东新华医疗器械股份有限公司 | Chemical indicator card for dry heat sterilization |
| CN101214386B (en) * | 2008-01-19 | 2011-07-13 | 山东新华医疗器械股份有限公司 | Dry heat sterilization chemical indicator and indicating card and preparation thereof |
| CN103649700A (en) * | 2011-04-15 | 2014-03-19 | 基比特技术公司 | Time-temperature indicator system I |
| CN103781498A (en) * | 2011-07-15 | 2014-05-07 | 茵赛普特斯股份有限公司 | System, method and device for ozone sanitization of continuous positive airway pressure devices |
| CN104873279A (en) * | 2015-06-09 | 2015-09-02 | 南京巨鲨显示科技有限公司 | Indicator card for use in sterilization monitor package |
| CN104884010A (en) * | 2013-01-11 | 2015-09-02 | 史密夫及内修公开有限公司 | Moisture indicator dressing |
| CN204676076U (en) * | 2015-05-28 | 2015-09-30 | 甘肃农业大学 | A kind of temperature instruction Erlenmeyer flask |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104730862B (en) * | 2013-12-19 | 2020-06-19 | 乐凯华光印刷科技有限公司 | Negative image photosensitive composition and heat-sensitive plate made of the same |
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- 2016-08-29 CN CN201610737826.5A patent/CN106362180B/en active Active
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1034393A (en) * | 1988-01-23 | 1989-08-02 | 沈阳市第一制药厂劳动服务公司 | Disinfecting indicator using high-pressure steam |
| JPH0383685A (en) * | 1989-08-29 | 1991-04-09 | Konica Corp | Method for forming thermal transfer image |
| CN101214386B (en) * | 2008-01-19 | 2011-07-13 | 山东新华医疗器械股份有限公司 | Dry heat sterilization chemical indicator and indicating card and preparation thereof |
| CN102061329A (en) * | 2010-11-29 | 2011-05-18 | 山东新华医疗器械股份有限公司 | Chemical indicator card for dry heat sterilization |
| CN103649700A (en) * | 2011-04-15 | 2014-03-19 | 基比特技术公司 | Time-temperature indicator system I |
| CN103781498A (en) * | 2011-07-15 | 2014-05-07 | 茵赛普特斯股份有限公司 | System, method and device for ozone sanitization of continuous positive airway pressure devices |
| CN104884010A (en) * | 2013-01-11 | 2015-09-02 | 史密夫及内修公开有限公司 | Moisture indicator dressing |
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| CN106362180A (en) | 2017-02-01 |
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