CN106177433A - A kind of Hyperglycemic health care compositions comprising leaf of Cyclocarya paliurus Iljinskaja, Radix Puerariae and Rhizoma Polygonati Odorati - Google Patents
A kind of Hyperglycemic health care compositions comprising leaf of Cyclocarya paliurus Iljinskaja, Radix Puerariae and Rhizoma Polygonati Odorati Download PDFInfo
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- CN106177433A CN106177433A CN201510213059.3A CN201510213059A CN106177433A CN 106177433 A CN106177433 A CN 106177433A CN 201510213059 A CN201510213059 A CN 201510213059A CN 106177433 A CN106177433 A CN 106177433A
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Abstract
The invention discloses a kind of health composition containing leaf of Cyclocarya paliurus Iljinskaja, Radix Puerariae and Rhizoma Polygonati Odorati, wherein the percentage by weight of three can be 1-98%: 1-98%: 1-98%.Described health composition can also comprise the free Folium Mori of choosing, Fructus Lycii, Rhizoma Polygonati, Thallus Laminariae (Thallus Eckloniae), Fructus Mume, Cortex Mori, Radix Ginseng, Radix Notoginseng, Fructus Ligustri Lucidi, Fructus Corni, Rhizoma Chuanxiong, Rhizoma Atractylodis, Radix Scrophulariae, Radix Rehmanniae, the Radix Paeoniae Alba, Radix Angelicae Sinensis, Radix Rhodiolae, Radix Panacis Quinquefolii, Aloe, Fructus Schisandrae Chinensis, Radix Ophiopogonis, Radix et Rhizoma Rhei (processed), the Rhizoma Anemarrhenae, Fructus Tribuli, Folium Ginkgo, the Radix Astragali, Herb Gynostemmae Pentaphylli, Fructus Momordicae charantiae, Radix Et Rhizoma Fagopyri Tatarici, Fructus Cucurbitae moschatae, Rhizoma amorphophalli, Herba Apii graveolentis, Stigma Maydis, Tremella, one or more of in the group that Hericium erinaceus (Bull. Ex Fr.) Pers. and Bulbus Allii are formed.Present invention also offers the application in terms of preparing blood sugar lowering, blood pressure lowering or health-care composition for reducing blood fat of the described health composition.The health composition of the present invention, based on natural drug, has no side effect, and has clear curative effect, synergism and substantially and is prone to the advantages such as masses take.
Description
Technical field
The invention belongs to field of health care food, be specifically related to a kind of comprise leaf of Cyclocarya paliurus Iljinskaja, Radix Puerariae and Rhizoma Polygonati Odorati
Hyperglycemic health care compositions and preparation thereof and purposes.
Background technology
Diabetes (diabetes mellitus, DM) are one group and are drawn by h and E factor interaction
The clinical syndrome risen, due to insulin secretion, definitely or relative deficiency and target tissue cell are to insulin
Sensitivity reduces, and causes the metabolism disorders such as sugar, fat, protein, with hyperglycemia as outstanding feature,
Cause series of clinical manifestations.Diabetes are the endocrine generations having genetic predisposition of a kind of common multi-pathogenesis
Thanking to disorder disease, along with growth in the living standard, its sickness rate, in the trend risen year by year, becomes and continues
The 3rd killer being detrimental to health after cancer, cardiovascular and cerebrovascular disease.According to World Health Organization (WHO)
New data shows, in following 15 years, the diabetics number of China is up to current 4 times,
Whole world diabetics number will be present 2 times.The relevant diabetes stream that China completes for 1997
Row disease is learned investigation problem and show, and whole nation onset diabetes rate rises to 3.2% from 1% in 1980, northern
The sickness rate of Jing Shi is more than 4%, the more seriously morbidity of diabetes in the old people of more than 60 years old
Rate is more than 11%.The current research report display of 2012, China diabetes patient occupies the whole world first.
The most serious in the situation of western developed country diabetes, the U.S. estimates there are about the sugar of more than 16,000,000
Urine patient, accounts for the 6% of population.
" quenching one's thirst " or " diseases due to endogenous heat of ZANG FU organs " category of the diabetes spp traditional Chinese medical science.Diabetes are broadly divided into by modern medicine
Two types a: class is the insulin-dependent (TDDM) of I type, based on inherited genetic factors, mostly occurs
In teenager.The another kind of non-insulin-depending type for II type (NIDDM), because of insulin resistant and pancreas
Island element secretion relative deficiency or delay, cause blood glucose to raise, and course of disease elder may occur in which the complication of diabetes,
It is mainly in and grows up or middle-aged and elderly people.In all diabeticss, 90% is above suffering from type ii diabetes.
At present, the treatment of diabetes is except with going back some orally-taken blood sugar reducing medicines of adapted in addition to insulin, such as: sulfonylurea,
Metformin class, alpha-glucosidase inhibitor, thiazolidone etc..Although western medicine effect comparison is bright
Aobvious, but side effect is big, as easily caused hypoglycemia, lactic acidosis, intestinal discomfort etc..Although insulin is treated
Method and oral antidiabetic drug can greatly reduce the mortality rate of diabetics, but patient can produce multiple concurrently
Disease, some complication more can cause people in fatal position than diabetes itself to a certain extent.Therefore, for sugar
Urine disease, there is no good radical treatment at present.
This disease such as can not get controlling, it will causes severe chronic complication and then disables lethal.Therefore, add
The prophylactico-therapeutic measures of strong diabetes is paid attention to by countries in the world, research prevent and treat diabetes newtype drug and
Health food is the advanced subject of domestic and international association area.Non-medication treatment diabetes have become current doctor
, threpsology, one of the focus of food scientific research.Although the enterprise that lot of domestic and international is big and scientific research machine
Structure, falls over each other to research and develop hypoglycemic medicine or substitute products, but the most all because of expensive, carrier the most not
Preferable, effect unstable or take trouble and not by people's recognition and acceptance.
Additionally, hypertension, hyperlipidemia are also puzzlements people " modern civilization diseases " in recent years, to human body
Healthy is very harmful, similar with diabetes to its difficulty prevented and treated.
Hypertension is a kind of with the abnormal cardiovascular disease rising a height of principal character of arterial pressure.The cause of disease is divided into former
Essential hypertension and secondary hypertension.The former accounts for the 90% of hypertension, referred to as hypertension
(hypertension).Hypertension is defined as by " WHO/ISH guide in 1999 ": do not take anti-high blood
Pressure drug condition under, shrink pressure ＞ 18.7kpa and diastolic pressure ＞ 12.0kpa, and according to blood pressure raise degree,
The quantity of risk factor, the degree of target organ damage and and the clinical setting deposited hypertension is divided into three
Phase: (1) mild hypertension: without organ injury objective condition；(2) moderate hypertension: at least
(left ventricular hypertrophy, arteria retina narrows, and albuminuria and serum creatinine raise, ultrasonic in organ injury performance
Inspection has arteriosclerosis plaque)；(3) severe hypertension: the clinical manifestation (heart strand of organ injury occurs
Bitterly, myocardial infarction, heart failure, transient ischemic attack, apoplexy, hypertensive encephalopathy, retina
Hemorrhage, serum creatinine ＞ 10mmol/L and renal failure, arteriosclerosis obliterans).Primary disease belongs to the traditional Chinese medical science
The category such as " dizziness ", " headache ".
Hyperlipemia (hyperlipemia) also known as hyperlipoproteinemia, can behave as hypercholesterolemia,
Hypertriglyceridemia or both have concurrently, it is with tremulous pulse medicated porridge sample hardening, diabetes, fatty liver, nephropathy
The closest etc. relation.Consequence is especially had day by day to cause people in the morbidity of cardiovascular and cerebrovascular disease
Attention.The traditional Chinese medical science thinks that hyperlipemia belongs to the categories such as " turbid resistance ", " phlegm-damp ", " fat ", " damp and hot ".
Hyperglycemia, hypertension, hyperlipidemia (" three high ") cause of disease are complicated, and the current cause of disease is not completely clear and definite,
Doctor trained in Western medicine it is generally acknowledged its mainly by inherited genetic factors, environmental factors, hyperinsulinemia and insulin resistant,
Obesity, Anomalous lipid metablism etc. influence each other caused.Although the comparitive study of western medical treatment is certainly at present, but
The treatment difficulty being combined disease and complication thereof is relatively big, can cause the side effect that degree is different, patient simultaneously
Often it is difficult to stand, it is impossible to adhere to treatment.The traditional Chinese medical science to the understanding of above-mentioned disease and preventing and treating, is then from entirety
Conditioning, determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs are started with, although do not have Western medicine quick, but nursed one's health by entirety, symptom and index
Will be effectively controlled, can effectively protect target organ etc. simultaneously.From clinically, the highest blood
Fat, hyperglycemia, hypertensive patients occur, reciprocal causation.Scientific research proves, slight long-term slow
Property hyperglycemia just can cause the generation of all chronic complicating diseases, and long-term blood pressure increases, and again results in each
Plant the generation of diseases of cardiovascular and cerebrovascular systems.Recently, more result of study confirms, prevent to reach and
Complication is delayed to occur and the purpose of development, it should extremely to emphasize the control of many factors, such as at II
In patients with type Ⅰ DM, in addition to strict glycemic control, blood pressure level, also should take strictly to control blood fat
Level, strictly controls the measures such as body weight, conventional anticoagulant therapy, to reduce the wind of macroangiopathy further
Danger.But the Chinese medicine composition that can prevent or treat " three high " so far is known clearly very few simultaneously, it is possible to
Obtaining satisfied curative effect and the high pharmaceutical composition of patient compliance rarely has report especially, therefore, research is opened
Send out the safely and effectively medicine that can prevent simultaneously and treat " three high ", be the task of top priority, extremely urgent.
In the last few years, from natural product, the new composition having physiologically active or lead compound are found to open
Send out new drug or health food base section has become the focus of global concern and research.Seek blood sugar lowering, blood pressure lowering and fall
Its functional factor is also dissected, and then Development and Production goes out blood sugar lowering, blood pressure lowering, fall by fat food resource
The Material for Health Food of blood fat food is expected to become the good approach treating these diseases.
Cyclocarya paliurus Iljinskaja: (cyclocarya paliurus (Batal.) Ijinsk) belongs to the arbor of Juglandaceae cyclocarya
Plant.The most only deposit one, peculiar for China, it is one of the endangered plants of special-protection-by-the-State, extensively divides
Being distributed in Yangtze river basin each province, Jiangxi Province is northern and hilly and mountainous land distribution in middle part is more.According to " China's book on Chinese herbal medicine "
Record, Cyclocarya paliurus Iljinskaja have dispel the wind, anti-inflammatory analgetic and parasite killing stop the effects such as overworked.Its main component have saponin,
Flavone, terpenoid, polysaccharide, trace element etc..Research shows that leaf of Cyclocarya paliurus Iljinskaja has multiple efficacies, such as blue or green
Money Folium Salicis Babylonicae can substantially suppress lipase active, reduce digesting and assimilating of fat, and can promote lipid material
Metabolic breakdown, can effectively reduce blood glucose, be obviously improved carbohydrate tolerance, antioxidation, resisting fatigue etc..Cyclocarya paliurus Iljinskaja
The exploitation of leaf system row health promoting product, will enrich the health-product market of China, improves the healthy living of the people
Level.
Radix Puerariae: (Puerariae Radix) is the dry root of legume pueraria lobata, practises and claims Herba Gelsemii Elegantis.Autumn,
Season in winter two excavates, sweet in the mouth, pungent, cool in nature.There is expelling pathogenic factors from muscles for reducing heat, rash, promoting the production of body fluid to quench thirst, yang invigorating antidiarrheal
Merit, be usually used in exterior syndrome heating, stiff nape and back, measles without adequate eruption, calentura is thirsty, the deficiency of YIN is quenched one's thirst, diarrhea of heat type
Hematodiarrhoea and diarrhea due to hypofunction of the spleen.Modern pharmacology research shows, Radix Puerariae has dilating coronary blood vessel and improves the heart
Myocardial ischemia anaerobic condition, blood pressure lowering, blood sugar lowering, suppression platelet aggregation beta-receptor block, improve brain blood
The effects such as circulation.
Rhizoma Polygonati Odorati: (Polygonatum odoratum (Mill.) Druce), for Liliaceae herbaceos perennial.
Originate in In Southwest China, but wild distribution is the widest.Cold-resistant, the most resistance to the moon, like wet environment, suitably give birth to
It is longer than the chesson abundant containing humus." stem is tetanic, like bamboo arrow shaft, has for Collective Notes to the Canon of Materia medica cloud
Joint ", therefore have the name of Rhizoma Polygonati Odorati.The rhizome of plant can hyoscine.Rhizoma Polygonati Odorati tool yin nourishing, moisturize, heat clearing away, life
The effect such as Tianjin, cough-relieving, can be used as tonic, cures mainly consumption of YIN caused by febrile disease, deficiency-heat cough caused by dryness, heart disease, sugar
The diseases such as urine disease, tuberculosis, and high-grade nourishing food, delicacies and beverage can be made, with health role.
Although producing at present and there is the medicine of function of polysaccharide and substitute products are of a great variety, but have fall blood concurrently
The health product mainly comprising leaf of Cyclocarya paliurus Iljinskaja, Radix Puerariae and Rhizoma Polygonati Odorati of sugar, blood pressure lowering and hypolipemic function are the most not
Appear in the newspapers.
Summary of the invention
The present inventor, through extensively collecting exploration blood sugar lowering proved recipe among the people, in immense medicine food raw material, passes through
Long-term research and practice, obtain unexpectedly one have concurrently blood sugar lowering, blood pressure lowering and hypolipemic function,
Comprise the health composition of leaf of Cyclocarya paliurus Iljinskaja, Radix Puerariae and Rhizoma Polygonati Odorati, thus overcome on present in prior art
State defect.
According to an aspect of the invention, it is provided a kind of health care comprising leaf of Cyclocarya paliurus Iljinskaja, Radix Puerariae and Rhizoma Polygonati Odorati
Compositions, wherein the percentage by weight of leaf of Cyclocarya paliurus Iljinskaja, Radix Puerariae and Rhizoma Polygonati Odorati is 1-98%:1-98%:1-98%.
In one embodiment of the invention, the percentage by weight of leaf of Cyclocarya paliurus Iljinskaja, Radix Puerariae and Rhizoma Polygonati Odorati is
10-80%:10-80%:10-80%.
Preferably, the percentage by weight of leaf of Cyclocarya paliurus Iljinskaja, Radix Puerariae and Rhizoma Polygonati Odorati is 20-60%:20-60%:
20-60%.
It is further preferred that the percentage by weight of leaf of Cyclocarya paliurus Iljinskaja, Radix Puerariae and Rhizoma Polygonati Odorati is 35%:35%:30%.
In yet another embodiment of the present invention, above-mentioned health composition also can comprise the free Fructus Lycii of choosing
Son, Rhizoma Polygonati, Thallus Laminariae (Thallus Eckloniae), Fructus Mume, Cortex Mori, Radix Ginseng, Radix Notoginseng, Fructus Ligustri Lucidi, Fructus Corni, Rhizoma Chuanxiong, grey
Art, Radix Scrophulariae, Radix Rehmanniae, the Radix Paeoniae Alba, Radix Angelicae Sinensis, Radix Rhodiolae, Radix Panacis Quinquefolii, Aloe, Fructus Schisandrae Chinensis, Radix Ophiopogonis,
Radix et Rhizoma Rhei (processed), the Rhizoma Anemarrhenae, Fructus Tribuli, Folium Ginkgo, the Radix Astragali, Herb Gynostemmae Pentaphylli, Fructus Momordicae charantiae, Radix Et Rhizoma Fagopyri Tatarici, Fructus Cucurbitae moschatae, Rhizoma amorphophalli,
One or more of in the group that Herba Apii graveolentis, Stigma Maydis, Tremella, Hericium erinaceus (Bull. Ex Fr.) Pers. and Bulbus Allii are formed.
In the present invention, described health composition can be carried out by the preparation method of any routine in this area
Preparation.
According to another aspect of the present invention, it is provided that described health composition is preparing blood sugar lowering, fall blood
Application in terms of pressure or health-care composition for reducing blood fat.
According to a further aspect of the invention, it is provided that a kind of medicine system containing described health composition
Agent.
The health composition of the present invention can be prepared as any with pharmaceutically acceptable adjuvant as required
Suitably oral formulations is for blood sugar lowering, blood pressure lowering or blood fat reducing.
In yet other embodiments, described oral formulations can be tablet, capsule,
The dosage forms such as granule, powder, effervescent, bagged steeping drug.
In yet other embodiments, described pharmaceutically acceptable adjuvant such as can select
From pregelatinized Starch, beta-schardinger dextrin-, carbomer, microcrystalline Cellulose, hydroxypropyl methyl cellulose, low take
For hydroxypropyl cellulose, Polyethylene Glycol (PEG), sodium carboxymethyl cellulose, methylcellulose, ethyl
Cellulose, mannitol, cross-linking sodium carboxymethyl cellulose, lactose, polyvinylpyrrolidone (PVP),
One in magnesium stearate, Pulvis Talci, micropowder silica gel, aspartame, sodium bicarbonate, sodium carbonate or more
Multiple.
Effect activity of each primary raw material medicine in the present invention
Leaf of Cyclocarya paliurus Iljinskaja: mildly bitter flavor, pungent, property is put down.Have invigorating the spleen for eliminating dampness, Clearing heat and removing obstruction of fu-organs, depressed liver-energy dispersing and QI regulating,
The effect of enriching yin and nourishing kidney, to because dysfunction of the spleen, expectorant are turbid, addiction delicious food savoury, lazy dynamic, abdominal distention food stagnation,
The liver silt stagnation of QI and the obesity that causes, have good improvement.
Radix Puerariae: sweet in the mouth, pungent, cool in nature.Attach to the lung and stomach meridians.Have expelling pathogenic factors from muscles for reducing heat, rash, promoting the production of body fluid to quench thirst,
Effect of yang invigorating antidiarrheal, the deficiency of YIN thirsty for exterior syndrome heating, stiff nape and back, measles without adequate eruption, calentura disappears
Yearningly, the disease such as diarrhea of heat type hematodiarrhoea, diarrhea due to hypofunction of the spleen.
Rhizoma Polygonati Odorati: yin nourishing, moisturize, heat clearing away, promote the production of body fluid, cough-relieving, can be used as tonic, cure mainly calentura wound
The disease such as the moon, deficiency-heat cough caused by dryness, heart disease, diabetes, tuberculosis.
Technical scheme has the advantage that
The health composition of the present invention, based on natural drug, has no side effect, and makes patient at normal drink
In the case of food, consciously safeguard glucostasis, it is thus achieved that the non-drug therapy effect of diabetes；
The present invention is additionally contemplates that when preparing health composition the nutritive equilibrium of diabetics and metabolism are asked
Topic, is simultaneously applicable to hypertension and the prevention of hyperlipemic patients and treatment.
Detailed description of the invention
To further describe the present invention below in detail.It is pointed out that following description is only to this
The illustration of the technical scheme that invention is claimed, the not any restriction to these technical schemes.This
The content that the protection domain of invention is recorded with appended claims is as the criterion.
Embodiment 1
Formula forms: leaf of Cyclocarya paliurus Iljinskaja 1.0kg, Radix Puerariae 8.0kg, Rhizoma Polygonati Odorati 1.0kg.
Preparation method:
2.1 accurately weigh each taste Chinese medicine according to above-mentioned formula, clean by clean water, boil extraction 2 times；
For the first time add 12 times amount water, extracts 2 hours, add 10 times amount water for the second time, extract 1 hour, 100
Mesh filters；
2.2 united extraction liquid, filter, and filtrate is concentrated into 60 DEG C of heat and surveys relative density 1.05-1.08, standby；
2.3 filtrate is added in spray dryer, first preheating tower temperature, treat that inlet temperature reaches 210 DEG C ± 10
Charging is started after DEG C；The regulation of flow to be carried out, wind speed after charging, leaving air temp is controlled 95 DEG C ±
5 DEG C, obtain extract powder, seal powder with double-deck clean plastic bag packaging；
2.4 by extract powder and mannitol, mixes 3-5 minute；
2.5 by mixed material with 70% edible ethanol moistening soft material, cross 20 mesh, obtain wet granular, wet
Grain dries to obtain dry granule；
2.6 with 20 mesh and 60 eye mesh screen granulate, take less than 20 mesh and are more than the 60 dry granules of purpose by 3g/
Bag carries out subpackage, to obtain final product.
Embodiment 2
1, formula composition: leaf of Cyclocarya paliurus Iljinskaja 2.0kg, Radix Puerariae 1.0kg, Rhizoma Polygonati Odorati 7.0kg.
2, preparation method: with embodiment 1.
Embodiment 3
1, formula composition: leaf of Cyclocarya paliurus Iljinskaja 3.5kg, Radix Puerariae 3.5kg, Rhizoma Polygonati Odorati 3.0kg.
2, preparation method: with embodiment 1.
Embodiment 4
1, formula composition: leaf of Cyclocarya paliurus Iljinskaja 6.0kg, Radix Puerariae 2.0kg, Rhizoma Polygonati Odorati 2.0kg.
2, preparation method: with embodiment 1.
Embodiment 5
1, formula composition: leaf of Cyclocarya paliurus Iljinskaja 8.0kg, Radix Puerariae 1.0kg, Rhizoma Polygonati Odorati 1.0kg.
2, preparation method: with embodiment 1.
Embodiment 6
1, formula composition: leaf of Cyclocarya paliurus Iljinskaja 1.0kg, Rhizoma Polygonati Odorati 1.0kg, Rhizoma Dioscoreae 1.0kg, Fructus Lycii 1.0kg,
Radix Rhodiolae 1.0kg, Radix Ophiopogonis 1.0kg, Radix et Rhizoma Rhei (processed) 1.0kg, Fructus Schisandrae Chinensis 1.0kg, Rhizoma amorphophalli 1.0kg, monkey
Head mushroom 1.0kg.
2, preparation method: with embodiment 1.
Comparative example 1
Choose the sample as a comparison case 1 that leaf of Cyclocarya paliurus Iljinskaja 10kg is prepared by the preparation method in embodiment 1.
Comparative example 2
Choose the sample as a comparison case 2 that Radix Puerariae 10kg is prepared by the preparation method in embodiment 1.
Comparative example 3
Choose the sample as a comparison case 3 that Rhizoma Polygonati Odorati 10kg is prepared by the preparation method in embodiment 1.
The scope of the present invention is not limited to above example, and each component in above-described embodiment is all selected from
Commercial goods, by the preparation process that this area is conventional, can make multiple dosage form described on pharmaceutics,
Such as capsule, granule, powder, tablet, oral liquid, the bag bubble bitter edible plant etc..
Experimental example 1: blood sugar lowering is tested
1, material and method
1.1 samples and reagent: sample prepared by embodiment 1-6 and comparative example 1-3, be respectively designated as S1,
S2, S3, S4, S5, S6, and D1, D2, D3；Streptozotocin, SIGMA Products,
Specification: 1g/ props up, lot number: SLBJ7785V；Detection kit for insulin, import subpackage, Nanjing is built up
Bio-engineering corporation, 20141022；The sodium chloride injection (normal saline) of 0.9%, specification: 250ml/
Bottle, Kelun Pharm Ind Co., Ltd., Sichuan, lot number: C13102005-1；High lipid food formula (79%
Basal diet+1% cholesterol+15% fresh yolk+5% Adeps Sus domestica), picric acid etc..
1.2 instrument W-80A eddy mixers, Instrument Factory of Shanghai Medical Univ.'s product；Electronic balance, mettler
Toledo, made by mettler-toledo group, model: p1303；LDZ5-2 centrifuge, north
Jing Yiyonglixinjichang；Johnson & Johnson surely person of outstanding talent's blood glucose meter (Johnson & Johnson (Chinese) medical device company limited)；
BECKMAN Synchron CX5 fully automatic blood biochemistry analyzer (U.S.)；Microplate reader, bio-rad
(U.S.), model: iMark；DCA2000 type glycolated hemoglobin analysis, public for Bayer Bitterfeld GmbH
Department's product；Other: platform balance, fixing cage etc..
1.3 laboratory animal SPF level SD rats, body weight 160～180g, male, big by south medical courses in general
Experimental Animal Center provides, the quality certification number: SCXK (Guangdong) 2011-0015.Animal is in SPF level barrier
Level Animal House is raised, and animal use credit number is: SYXK (Guangdong) 2012-0081.
1.4 dosage arrange adult's plan dosage and are 3.0g/60kg BW days, and human body 10 times amount is rat
Dosage, dosage is with crude drug gauge.
1.5 statistical analysis use SPSS17.0 statistical software to carry out data process, and parameter mean ±
Standard deviationRepresenting, comparing between group and use ANOVA variance analysis test, p ＜ 0.05 is for there being statistics
Learn difference.
2. method and result
2.1 method
2.1.1 rat feed normal diet: Semen Maydis powder 80%, flour 15%, analysis for soybean powder 5%；High fat
Feedstuff: 79% basal diet+1% cholesterol+15% fresh yolk+5% Adeps Sus domestica.
2.1.2 modeling: take 160-180gSPF level SD rat 110, male, body weight 160～180g,
Adaptability takes 10 after feeding one week and is only used as Normal group, feeds with chow diet, and other respectively organizes elder generation
Feed 1 month with high lipid food, after selective examination blood lipids index is significantly raised, lumbar injection STZ 35mg/kg
(STZ is before use by the citric acid/sodium citrate buffering of 0.1mmol/LpH=4.5 for induced Diabetic model
Liquid is made into the solution of 6mg/mL, and is finished in 60min).7d after injection, docking gathers sky
Abdomen venous blood, measures blood glucose with blood glucose meter, is considered as being modeled as more than or equal to 16.7mmol/L by blood glucose value
Merit.After model stability, according to blood-fat and blood sugar height packet, it is orally administered to test medicine and control drug,
Observe indices.
2.1.3 it is grouped and is administered: preferable 100 the modeling success animals of state of choosing are according to blood glucose value and body
Weight average is even is divided into 10 groups: often group 10, i.e. type ii diabetes model control group (giving distilled water),
S1 group, S2 group, S3 group, S4 group, S5 group, S6 group, D1 group, D2 group and D3 group.Normally
The SD rat of not modeling 10 is Normal group (giving distilled water).Each group is administered orally by corresponding dosage
It is administered, is administered once daily, dosage period: 4 weeks (4W).
2.2 testing index
2.2.1 use blood glucose meter respectively measure administration before and be administered after 2W and 4W blood glucose value.
2.2.2 serum insulin, saccharification hemoglobin content are detected.
2.2.4 carbohydrate tolerance test: terminate a few days ago to detect in experiment；Carbohydrate tolerance detects: animal fasting
About 6 hours, each group gave variable concentrations given the test agent, oral administration of glucose 2.0g/kg after 15-20 minute,
Measuring to the blood glucose value of after glucose 0,0.5,2 hours, observing and nursing matched group is given with given the test agent group
The change of each time point Area under the curve of blood glucose after glucose.Area under the curve of blood glucose=1/2 × (0 hour blood
Sugar value+0.5 hours blood glucose value) × 0.5+1/2 × (2 hours blood glucose value+0.5 hours blood glucose value) × 1.5=
0.25 × (0 hours blood glucose value+4 × 0.5 hours blood glucose value+3 × 2 hours blood glucose value).
2.3 result
2.3.1 the impact on type ii diabetes rat blood sugar
From table 1, comparing with Normal group, it is notable that the front Glycemia Decline of administration respectively organizes rat blood sugar
Raise, show diabetes model modeling success.After being administered 2w, compare with model control group, S1-S6
Group and D1 group blood glucose all have decline.After being administered 4w, S1-S6 group and D1 group blood glucose all have decline.
The impact on type ii diabetes rat blood sugar of table 1. sample
Note: compare with Normal group:#P ＜ 0.05,##P ＜ 0.01；Compare with model group: * p ＜ 0.05,
* p ＜ 0.01
2.3.2 on type ii diabetes rat blood serum insulin and the impact of glycolated hemoglobin
From table 2, comparing with Normal group, model control group feeds high lipid food and Glycemia Decline
After, rat blood serum insulin substantially reduces (p ＜ 0.01), glycolated hemoglobin significantly raised (p ＜ 0.01),
Show olive Antihyperlipidemia capsule modeling success.Compare with model control group, S1-S6 group and D1 group serum
Insulin all has increase.Compare with model control group, under S1-S6 group and D1 group glycolated hemoglobin all have
Fall (comparing P ＜ 0.05 with model group).
Table 2. sample is on type ii diabetes rat blood serum insulin and the impact of glycolated hemoglobin
| Group | n | Insulin (mmol/L) | Glycolated hemoglobin (mmol/L) |
| Normal group | 10 | 18.42±2.83 | 3.65±0.71 |
| Model control group | 10 | 8.92±2.42## | 9.52±1.41## |
| S1 group | 10 | 12.21±2.35* | 6.96±1.74* |
| S2 group | 10 | 12.52±2.44* | 6.87±1.62* |
| S3 group | 10 | 13.41±1.83** | 6.42±1.28** |
| S4 group | 10 | 12.40±2.26* | 7.01±1.36* |
| S5 group | 10 | 12.58±2.19* | 7.10±1.45* |
| S6 group | 10 | 12.69±2.17* | 6.99±1.29* |
| D1 group | 10 | 12.15±2.11* | 6.95±1.35* |
| D2 group | 10 | 9.87±2.74 | 8.63±2.31 |
| D3 group | 10 | 9.90±2.85 | 8.54±2.06 |
Note: compare with Normal group:#P ＜ 0.05,##P ＜ 0.01；Compare with model group: * p ＜ 0.05,
* p ＜ 0.01
2.3.3 to type ii diabetes rat carbohydrate tolerance test result
From table 3, comparing with model control group, the Area under the curve of blood glucose of S1-S6 group and D1 group is equal
There is decline.
Table 3. sample is to type ii diabetes rat carbohydrate tolerance test result
| Group | n | Area under the curve of blood glucose |
| Normal group | 10 | 12.14±0.95 |
| Model control group | 10 | 38.60±6.45## |
| S1 group | 10 | 30.22±6.15* |
| S2 group | 10 | 31.57±6.48* |
| S3 group | 10 | 27.94±5.78** |
| S4 group | 10 | 28.89±6.76* |
| S5 group | 10 | 30.81±6.19* |
| S6 group | 10 | 31.30±5.74* |
| D1 group | 10 | 30.44±6.86* |
| D2 group | 10 | 35.47±5.97 |
| D3 group | 10 | 36.83±6.40 |
Note: compare with Normal group:#P ＜ 0.05,##P ＜ 0.01；Compare with model control group: p is equal
More than 0.05.
3. conclusion: S1-S6 and D1 has obvious hypoglycemic activity, and S1-S6 to diabetic model rats
Compositions in terms of blood sugar lowering, create significant synergy.
Experimental example 2: lipid-lowering test
1, material and method
1.1 medicines and reagent: sample prepared by embodiment 1-6 and comparative example 1-3, be respectively designated as S1,
S2, S3, S4, S5, S6, and D1, D2, D3；The sodium chloride injection (normal saline) of 0.9%,
Specification: 250ml/ bottle, Kelun Pharm Ind Co., Ltd., Sichuan, lot number: C13102005-1；High fat is raised
Material formula (79% basal diet+1% cholesterol+15% fresh yolk+5% Adeps Sus domestica), distilled water, picric acid,
Deng.
1.2 instrument W-80A eddy mixers, Instrument Factory of Shanghai Medical Univ.'s product；Electronic balance, mettler
Toledo, made by mettler-toledo group, model: p1303；LDZ5-2 centrifuge, north
Jing Yiyonglixinjichang；BECKMAN Synchron CX5 fully automatic blood biochemistry analyzer is (beautiful
State)；Other: platform balance, fixing cage etc..
1.3 laboratory animal SPF level SD rats, body weight 160～180g, male, big by south medical courses in general
Experimental Animal Center provides, the quality certification number: SCXK (Guangdong) 2011-0015.Animal is in SPF level barrier
Level Animal House is raised, and animal use credit number is: SYXK (Guangdong) 2012-0081.
1.4 dosage arrange adult's plan dosage and are 3.0g/60kg BW days, and human body 10 times amount is rat
Dosage, dosage is with crude drug gauge.
1.5 statistical analysis use SPSS17.0 statistical software to carry out data process, and parameter mean ±
Standard deviation (x ± s) represents, comparing between group and use ANOVA variance analysis test, p ＜ 0.05 is for there being statistics
Learn difference.
2. method and result
2.1 packets take SPF level SD rat 110 with method, male, and body weight 160～180g is suitable
Answering property takes 10 after feeding one week and is only used as Normal group, feeds with chow diet；Residue gives high fat
Forage feed.Continuous nursing 4 weeks (determining that modeling is the most successful by timing blood drawing detection four items of blood lipid tests)
After, preferable 100 the modeling success animals of state of choosing uniformly are divided into 10 according to blood fat numerical value and body weight
Group: often group 10, i.e. hyperlipemia model matched group (giving distilled water), S1 group, S2 group, S3
Group, S4 group, S5 group, S6 group, D1 group, D2 group and D3 group.
High lipid food is started to be administered and continue (just feeding high lipid food by above packet situation after feeding 4 weeks
Often matched group feeds normal diet), every day 1 time, successive administration 4w.After last is administered, fasting overnight,
After next day weighs in, chloral hydrate anesthesia, put to death after postcava blood sampling.Take supernatant after Li Xin to survey
Biochemical indicator in serum.
2.2 Testing index:
(1) general status is observed, and records body weight weekly.
(2) each group rat blood serum lipid index: orbital venous plexus takes blood every two weeks, separation Virus monitory:
T-CHOL (TC), triglyceride (TG), high density lipoprotein (HDL-C), low density lipoprotein, LDL
(LDL-C)。
2.3 result
2.3.1 on the impact of TC, TG, HDL-C, LDL-C in serum
Iipid data in rat blood serum after table 4. modeling success even group-division
Note: compare with Normal group:#P ＜ 0.05,##P ＜ 0.01；Compare with model control group: p is equal
More than 0.05.
Table 5. is each after being administered 4W organizes Iipid data in rat blood serum
Note: compare with Normal group:#P ＜ 0.05,##P ＜ 0.01；Compare with model group: * p ＜ 0.05,
* p ＜ 0.01
From table 4, compare with Normal group, after model control group feeds high lipid food 4W, rat
Serum TC, LDL-C significantly raise (p ＜ 0.01), TG significantly raised (p ＜ 0.05), show hyperlipemia
Disease rat model modeling success.4 groups uniformly it are divided into according to blood lipid level.
From table 5, after being administered 4W, comparing with model control group, S1-S6 group and D1 group can reduce
TC, TG, LDL-C level (p ＜ 0.05 or p ＜ 0.01) in serum.
3. conclusion: S1-S6 and D1 has obvious effect for reducing blood fat, and S1-S6 to Hyperlipemia model rat
Compositions in terms of blood fat reducing, create significant synergy.
Experimental example 3: blood pressure lowering is tested
1, material and method
1.1 medicines and reagent: sample prepared by embodiment 1-6 and comparative example 1-3, be respectively designated as S1,
S2, S3, S4, S5, S6, and D1, D2, D3；The sodium chloride injection (normal saline) of 0.9%,
Specification: 250ml/ bottle, Kelun Pharm Ind Co., Ltd., Sichuan, lot number: C13102005-1；Distilled water,
Picric acid, etc..
1.2 instrument DKB-501A type super constant temperature water tanks, reliable test Instrument Ltd. for Shanghai is gloomy
Product；Constant Temp. Oven, for Changsha medical apparatus and instruments factory product；Powlab/4sp ML125 type without
Wound pressure measuring system (ML125/R NIBP, MLT1199 BPTrans-ducer/Cable Kit), Australia is big
Leah Ai De Instrument Ltd. product；MP120-1 electronic balance, for Shanghai Second Balance Factory
Product.
1.3 laboratory animal SPF level SHR rat, body weight 190～230g, male, logical by Beijing dimension
Li Hua laboratory animal Technology Co., Ltd. provides, the quality certification number: SCXK (capital) 2012-0001.Animal in
SPF level barrier level Animal House is raised, and animal use credit number is: SYXK (Guangdong) 2012-0081,
SPF level WISTAR male rat, Beijing Vital River Experimental Animals Technology Co., Ltd. provides, real
Testing animal productiong credit number is: SCXK (capital) 2012-0001.
1.4 dosage arrange adult's plan dosage and are 3.0g/60kg BW days, and human body 10 times amount is rat
Dosage, dosage is with crude drug gauge.
1.5 statistical analysis use SPSS17.0 statistical software to carry out data process, and parameter mean ±
Standard deviation (x ± s) represents, comparing between group and use ANOVA variance analysis test, p ＜ 0.05 is for there being statistics
Learn difference.
2. method and result
10 groups are divided at random, often group 10 by male for 9-10 week old spontaneous hypertensive rat (SHR),
I.e. hypertension model matched group (giving distilled water), S1 group, S2 group, S3 group, S4 group, S5 group,
S6 group, D1 group, D2 group and D3 group.Separately take normal WISTAR rat 10 for Normal group
(giving distilled water).Each treated animal gavage respectively gives various dose drug, every day 1 time, is administered 4 altogether
Week.Within 4 weeks, rat tail artery blood is detected with noinvasive arteria caudalis pressure measuring system before being administered and after being administered
Pressure value (shrinks pressure, SAP, mmHg).
Noinvasive tail sleeve method (NIBP): rat is put into rat fixator, exposes rat-tail.Take with infrared
Warmer, temperature is set to 38 DEG C, and after irradiating heating rat-tail about 10min, rat-tail deliquescing, rat-tail is moved
Arteries and veins is fully expanded.Be passed through pressurizeing tail sleeve and being fixed on the root of rat-tail, make rat tail artery with
PowerlabML125/R noinvasive arteria caudalis blood pressure determination is analyzed the pulse transducer of system and is in close contact, with
Time observation system pulse wave, can start when stable pulse wave occurs to measure blood pressure.Treat that animal is pacified
After quiet, select 90～420BPM (rat pressurization shelves) to tail sleeve inflating pressure, it is seen that pulse wave gradually subtracts
Little to disappearing, then tail sleeve starts venting, and Mus set pressure reduces, and when pressure is equal to when shrinking pressure, starts
Pulse wave occur, the pressure value of this point is rat-tail and shrinks pressure.Repeated measure 3 times, averages.Meter
Calculating voltage drop value (drop-out value of blood pressure), before after administration, SAP deducts administration, SAP obtains.The results are shown in Table 6:
The impact to SHR rat blood pressure (SAP, mmHg) of table 6 sample
Note: compare with Normal group: # is P ＜ 0.01；Compare with model control group: * is P ＜ 0.05.
Result shows, compares with Normal group, and model control group rat blood pressure significantly raises, it is seen that from
The success of Essential hypertension rat model.Can show at administration 4W with model control group, S1-S6 group and D1 group
Write the blood pressure (P ＜ 0.05) reducing SHR rat.
3. conclusion: S1-S6 and D1 sample has significant hypotensive activity, and the compositions of S1-S6 exists
Blood pressure lowering aspect creates significant synergy.
Present invention merely illustrates some claimed specific embodiments, one of them or
Technical characteristic described in more technical schemes can be with arbitrary one or more technical scheme phases
Combination, these are combined and the technical scheme that obtains also in the application protection domain, just as these are through group
As the technical scheme closed and obtain specifically is recorded in the disclosure of invention.
Claims (10)
1. a health composition, it comprises leaf of Cyclocarya paliurus Iljinskaja, Radix Puerariae and Rhizoma Polygonati Odorati.
Health composition the most according to claim 1, wherein leaf of Cyclocarya paliurus Iljinskaja, Radix Puerariae and Rhizoma Polygonati Odorati
Percentage by weight be 1-98%:1-98%:1-98%.
Health composition the most according to claim 1 and 2, wherein leaf of Cyclocarya paliurus Iljinskaja, Radix Puerariae and
The percentage by weight of Rhizoma Polygonati Odorati is 10-80%:10-80%:10-80%.
4. according to the health composition described in any one of claim 1-3, wherein leaf of Cyclocarya paliurus Iljinskaja, Radix Puerariae
It is 20-60%:20-60%:20-60% with the percentage by weight of Rhizoma Polygonati Odorati.
5. according to the health composition described in any one of claim 1-4, wherein leaf of Cyclocarya paliurus Iljinskaja, Radix Puerariae
It is 35%:35%:30% with the percentage by weight of Rhizoma Polygonati Odorati.
6. according to the health composition described in any one of claim 1-5, wherein said health composition
In also comprise choosing free Folium Mori, Fructus Lycii, Rhizoma Polygonati, Thallus Laminariae (Thallus Eckloniae), Fructus Mume, Cortex Mori, Radix Ginseng, Radix Notoginseng,
Fructus Ligustri Lucidi, Fructus Corni, Rhizoma Chuanxiong, Rhizoma Atractylodis, Radix Scrophulariae, Radix Rehmanniae, the Radix Paeoniae Alba, Radix Angelicae Sinensis, Radix Rhodiolae, west
Radix Panacis Quinquefolii, Aloe, Fructus Schisandrae Chinensis, Radix Ophiopogonis, Radix et Rhizoma Rhei (processed), the Rhizoma Anemarrhenae, Fructus Tribuli, Folium Ginkgo, the Radix Astragali, strand
Stock indigo plant, Fructus Momordicae charantiae, Radix Et Rhizoma Fagopyri Tatarici, Fructus Cucurbitae moschatae, Rhizoma amorphophalli, Herba Apii graveolentis, Stigma Maydis, Tremella, Hericium erinaceus (Bull. Ex Fr.) Pers. and Bulbus Allii
One or more of in the group formed.
7. the health composition described in any one of claim 1-6 is preparing blood sugar lowering, blood pressure lowering or fall
Application in blood fat health composition.
8. comprise a pharmaceutical preparation for health composition described in any one of claim 1-6, wherein
Described health composition and pharmaceutically acceptable adjuvant are prepared as oral formulations.
Pharmaceutical preparation the most according to claim 8, wherein said oral formulations is tablet, glue
Wafer, granule, powder, effervescent or bagged steeping drug.
Pharmaceutical preparation the most according to claim 8 or claim 9, wherein said pharmaceutically acceptable
Adjuvant is selected from pregelatinized Starch, beta-schardinger dextrin-, carbomer, microcrystalline Cellulose, hydroxypropyl methyl fiber
Element, low-substituted hydroxypropyl cellulose, Polyethylene Glycol (PEG), sodium carboxymethyl cellulose, methyl are fine
Dimension element, ethyl cellulose, mannitol, cross-linking sodium carboxymethyl cellulose, lactose, polyvinylpyrrolidine
Ketone (PVP), magnesium stearate, Pulvis Talci, micropowder silica gel, aspartame, sodium bicarbonate, carbonic acid
One or more of in sodium.
Priority Applications (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510213059.3A CN106177433A (en) | 2015-04-29 | 2015-04-29 | A kind of Hyperglycemic health care compositions comprising leaf of Cyclocarya paliurus Iljinskaja, Radix Puerariae and Rhizoma Polygonati Odorati |
| EP16785076.7A EP3125914B1 (en) | 2015-04-29 | 2016-04-28 | Compositions comprising cyclocarya paliurus extract and preparation method and uses thereof |
| EP16785077.5A EP3151843B1 (en) | 2015-04-29 | 2016-04-28 | Compositions comprising cyclocarya paliurus extract and preparation method and uses thereof |
| US15/128,827 US10413580B2 (en) | 2015-04-29 | 2016-04-28 | Compositions comprising Cyclocarya paliurus extract and preparation method and uses thereof |
| US15/128,835 US20170173101A1 (en) | 2015-04-29 | 2016-04-28 | Tea composition comprising cyclocarya paliurus and preparation method and uses thereof |
| EP16785075.9A EP3139941A4 (en) | 2015-04-29 | 2016-04-28 | Tea composition comprising cyclocarya paliurus and preparation method and uses thereof |
| PCT/CN2016/080551 WO2016173511A1 (en) | 2015-04-29 | 2016-04-28 | Compositions comprising cyclocarya paliurus extract and preparation method and uses thereof |
| PCT/CN2016/080553 WO2016173512A1 (en) | 2015-04-29 | 2016-04-28 | Tea composition comprising cyclocarya paliurus and preparation methord and uses thereof |
| US15/128,866 US10111923B2 (en) | 2015-04-29 | 2016-04-28 | Compositions comprising Cyclocarya paliurus extract and preparation method and uses thereof |
| PCT/CN2016/080547 WO2016173509A1 (en) | 2015-04-29 | 2016-04-28 | Compositions comprising cyclocarya paliurus extract and preparation method and uses thereof |
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| CN201510213059.3A CN106177433A (en) | 2015-04-29 | 2015-04-29 | A kind of Hyperglycemic health care compositions comprising leaf of Cyclocarya paliurus Iljinskaja, Radix Puerariae and Rhizoma Polygonati Odorati |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107087697A (en) * | 2017-03-29 | 2017-08-25 | 广西凌云县盘古生态产业发展有限公司 | It is a kind of can anti-trioxypurine sleeping type cyclocarya paliurus tea and preparation method thereof |
| CN107280006A (en) * | 2017-06-30 | 2017-10-24 | 武汉市百锐纳思生物科技有限公司 | It is a kind of that there is hypoglycemic, blood fat reducing function composition, beverage and its application |
| CN108851046A (en) * | 2018-06-04 | 2018-11-23 | 湖南百汉原健康中药生物有限公司 | A kind of method of integration of drinking and medicinal herbs traditional Chinese medicine extraction melbine |
| CN110651872A (en) * | 2019-11-09 | 2020-01-07 | 泉州市神草茶业有限责任公司 | Cyclocarya paliurus leaf substitute tea and preparation process thereof |
-
2015
- 2015-04-29 CN CN201510213059.3A patent/CN106177433A/en not_active Withdrawn
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107087697A (en) * | 2017-03-29 | 2017-08-25 | 广西凌云县盘古生态产业发展有限公司 | It is a kind of can anti-trioxypurine sleeping type cyclocarya paliurus tea and preparation method thereof |
| CN107280006A (en) * | 2017-06-30 | 2017-10-24 | 武汉市百锐纳思生物科技有限公司 | It is a kind of that there is hypoglycemic, blood fat reducing function composition, beverage and its application |
| CN108851046A (en) * | 2018-06-04 | 2018-11-23 | 湖南百汉原健康中药生物有限公司 | A kind of method of integration of drinking and medicinal herbs traditional Chinese medicine extraction melbine |
| CN110651872A (en) * | 2019-11-09 | 2020-01-07 | 泉州市神草茶业有限责任公司 | Cyclocarya paliurus leaf substitute tea and preparation process thereof |
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Application publication date: 20161207 |
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| WW01 | Invention patent application withdrawn after publication |