CN106075748B - The device of oncotherapy is carried out using wobbling magnet diffusion proton beam - Google Patents
The device of oncotherapy is carried out using wobbling magnet diffusion proton beam Download PDFInfo
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- CN106075748B CN106075748B CN201610614055.0A CN201610614055A CN106075748B CN 106075748 B CN106075748 B CN 106075748B CN 201610614055 A CN201610614055 A CN 201610614055A CN 106075748 B CN106075748 B CN 106075748B
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- proton beam
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1042—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy with spatial modulation of the radiation beam within the treatment head
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1042—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy with spatial modulation of the radiation beam within the treatment head
- A61N5/1043—Scanning the radiation beam, e.g. spot scanning or raster scanning
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1042—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy with spatial modulation of the radiation beam within the treatment head
- A61N5/1045—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy with spatial modulation of the radiation beam within the treatment head using a multi-leaf collimator, e.g. for intensity modulated radiation therapy or IMRT
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1077—Beam delivery systems
- A61N5/1081—Rotating beam systems with a specific mechanical construction, e.g. gantries
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N2005/1085—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy characterised by the type of particles applied to the patient
- A61N2005/1087—Ions; Protons
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Radiation-Therapy Devices (AREA)
Abstract
The present invention relates to a kind of therapies and device carrying out tumour using wobbling magnet diffusion proton beam, and this method comprises the following steps：First, the proton beam (10) of diverging is converged by concentrating element (1)；Secondly, the proton beam (10) after convergence is scattered by wobbling magnet (3), it is made to surround proton center Periodic Rotating, form a uniform line (11) on a large scale；Then, after the collimator (9) for which being passed through tumour leading portion, a homogeneous beam spot (12) consistent with tumor shape is obtained.Therapy using the present invention and device; the beam spot that the irradiation visual field, the uniformity are high greatly can be obtained, the beam spot is consistent with patient's tumor region, to protect the normal structure of patient to the full extent; this method greatly reduces the difficulty of construction and control, and is moved to the position of tumour insensitive.
Description
Technical field
The invention belongs to field of medical technology, and in particular to a kind of to carry out tumour using wobbling magnet diffusion proton beam
The method and device for the treatment of.
Background technology
Proton therapeutic mainly utilizes accelerator to generate the proton beam of certain energy, is arrived beam transfer by each electromagnetic component
Target area bombards tumour cell, achievees the effect that treatment.Since energy loss of the proton in substance shows sharp Bragg
Peak, therefore normal structure can be protected to the greatest extent while killing cancerous tumor cell, this makes proton therapeutic become current
One of state-of-the-art treating malignant tumor means in the world.
There are two types of basic modes for the treatment head that traditional proton therapeutic appts use：Scattering and scanning.Wherein, scattering method
It is to be achieved the purpose that lateral line extension, the dress by multiple low-angle elasticity Coulomb scattering when passing through scatter plate using proton
The shortcomings that setting is the proton beam for being difficult to obtain big irradiation field and high evenness, and complicated, causes rotary frame excessively stupid
Weight；The mode of scanning is to install a pair of of sweeping magnet in treatment head, and dosage is obtained by controlling the changes of magnetic field of sweeping magnet
The shortcomings that uniform irradiation field, the device is sensitive to tumour displacement itself, and control difficulty is big.
Invention content
In view of the deficiencies in the prior art, present invention offer is a kind of utilizes wobbling magnet diffusion proton beam to carry out
The uniform line of big irradiation field can be obtained in the method and device of oncotherapy；The control difficulty of beam spot is reduced, it will not be to normal
Tissue damage；Device is simple, build with it is easy to control.
To achieve the above objectives, the technical solution adopted by the present invention is：A kind of utilization wobbling magnet diffusion matter is provided
The method that beamlet carries out oncotherapy, includes the following steps：First, the proton beam of diverging is converged by concentrating element
It is poly-；Secondly, the proton beam after convergence is scattered by wobbling magnet, it is made to surround proton center Periodic Rotating, shape
At a large-scale uniform line；Then, homogeneous beam stream is adjusted by the collimator of tumour leading portion, by tumor region
Outer proton beam card falls；Finally, a homogeneous beam spot consistent with tumor shape is obtained.
Further, the proton beam after being converged by concentrating element passes through the first matter before entering wobbling magnet
Beamlet stream diagnostic device measures by force its section and stream.
Further, the proton beam after being scanned by wobbling magnet, then pass sequentially through energy modulator and range position
After shifting device is respectively adjusted the broadening of proton beam stream energy and range, into collimator.
Further, by the proton beam after energy modulator and the adjustment of range shifter, then pass through multi-leaf optical grating respectively
Beam spot shape on target is adjusted with patient's compensator, falls the proton beam card outside tumor region and according to patient tumors
After depth and Adjusting Shape beam energy, into collimator.
Further, it is additionally provided between range shifter and multi-leaf optical grating for being surveyed by force to proton beam flow section and stream
Second proton beam diagnostic device of amount.
The device of oncotherapy being carried out using wobbling magnet diffusion proton beam the present invention also provides a kind of, including is used for
The concentrating element that the proton beam of diverging is converged, for the proton beam after convergence to scatter, makes it in proton
Heart Periodic Rotating, the wobbling magnet for forming a large-scale uniformly line, after handling wobbling magnet
The homogeneous beam stream collimator that is adjusted, falls the proton beam card outside tumor region.
Further, it is equipped between the concentrating element and wobbling magnet for being cut to the proton beam after convergence
The first proton beam diagnostic device that face and stream measure by force.
Further, it is equipped with successively for the Energy Broadening to proton beam between the wobbling magnet and collimator
Energy modulator, the range shifter for being adjusted to proton beam stream energy range, for the proton beam after adjustment
The second proton beam diagnostic device that section and stream measure by force, for adjusting beam spot shape on target, by tumor region
Multi-leaf optical grating that outer proton beam card falls, for being compensated according to the depth of patient tumors and the patient of Adjusting Shape beam energy
Device.
The beneficial technical effect of the present invention lies in：
The therapy of the present invention should using wobbling magnet generation perpendicular to the mechanical periodicity magnetic field of proton beam
Magnetic field size is constant, direction cyclically-varying, and proton beam will surround beam center Periodic Rotating, shape behind the magnetic field
At the beam spot of an a wide range of high evenness, after the homogeneous beam spot is by the collimator before sufferer, one and disease are finally obtained
The consistent homogeneous beam spot in human tumour region, to protect the normal structure of patient；This method greatly reduces the difficulty of control, and
It is insensitive to the movement of knub position；Therapeutic device provided by the invention, it is simple in structure, it is easy to control.
Description of the drawings
Fig. 1 is the structure chart that wobbling magnet diffusion proton beam of the present invention carries out therapeutic apparatus for treating tumor；
Fig. 2 is wobbling magnet of the present invention and the schematic diagram of collimator being used cooperatively；
Fig. 3 is the fundamental diagram of wobbling magnet of the present invention.
In figure：
1- concentrating elements 2- the first proton beam diagnostic device 3- wobbling magnet 4- energy modulator 5- ranges
Shifter 6- the second proton beam diagnostic device 7- multi-leaf optical grating 8- patient's compensator 9- collimator 10- proton beams
The uniform line 12- homogeneous beam spots of 11-
Specific implementation mode
Below in conjunction with the accompanying drawings, the specific implementation mode of the present invention is described in further detail.
As shown in Figure 1, 2, be it is proposed by the present invention using wobbling magnet diffusion proton beam carry out therapeutic apparatus for treating tumor,
The device includes concentrating element 1, the first proton beam diagnostic device 2, wobbling magnet 3, energy modulator 4, range successively
Shifter 5, the second proton beam diagnostic device 6, multi-leaf optical grating 7, patient's compensator 8, collimator 9, above-mentioned each component pass through beam
Flow tube road is connected.Wherein, the first proton beam diagnostic device 2 and the second proton beam diagnostic device 6 are ionisation chamber.Rotation is swept
Magnet 3 is retouched to be powered by a three phase mains.
The proton beam 10 that the present invention is transferred to the diverging for the treatment of head is examined after line focus element 1 converges by proton beam
Disconnected device 2 measures diagnosis by force to its section and stream, is conveyed to wobbling magnet 3, which will will produce
Perpendicular to the magnetic field of the mechanical periodicity of proton beam, proton beam is under the action of the wobbling magnet, it will in line
Heart Periodic Rotating forms uniform line 11, the uniform line 11 after expansion on a large scale after wobbling magnet and passes through energy
It measures modulator 4 and range shifter 5 carries out Energy Broadening and modulation, its section is diagnosed by the second proton beam diagnostic device 6
It is strong with stream, to adjust depth of the proton beam in lesion, by patient's compensator 8 according to the depth and shape of patient tumors
Beam energy is adjusted, prevents tumour rear portion normal structure impaired, the combination of multi-leaf optical grating 7 and collimator 9 can be by lesion edge
Line card fall, the homogeneous beam spot 12 consistent with lesion shape is finally obtained, to avoid the normal structure of patient from being damaged.
As shown in figure 3, the wobbling magnet is utilized, perpendicular to proton beam, size is constant, direction cyclically-varying
Magnetic field, make the proton beam by the wobbling magnet by the periodically variable active force in direction, in the effect of the power
Under, proton beam will surround wobbling magnet center Periodic Rotating；Since proton beam itself is in Gaussian Profile, work as
When proton beam is rotated around wobbling magnet center, the proton beam of marginal portion will be superimposed, and it is uniform to form a center
The beam spot of distribution.In figure：Abscissa r/mm is the radius of turn of proton beam；Ordinate Beam profile are proton beam
Rotation profile.
The method that proton beam carries out oncotherapy is spread using wobbling magnet the present invention also provides a kind of, including as follows
Step：
1) convergence of proton beam 10 of diverging is got up by concentrating element 1, then leads to the proton beam 10 after convergence
The first proton beam diagnostic device 2 is crossed to carry out section to it and flow to measure by force；
2) by by the proton beam 10 after measurement, into wobbling magnet 3, wobbling magnet 3 utilizes its generation
Size it is constant, direction periodically variable Dipole magnet field drives proton beam to be rotated on target, obtain it is a wide range of it is high uniformly
The uniform line 11 of degree；
3) obtain uniform line 11 by energy modulator 4 and range shifter 5 respectively to its Energy Broadening and modulation；
4) it and then is again measured by the way that the second proton beam diagnostic device 6 is strong to the section of uniform line after modulation and stream；
5) by multi-leaf optical grating 7, beam spot shape on target is adjusted, the proton beam card outside tumor region is fallen；
6) tumour rear portion is being prevented just according to the depth of patient tumors and Adjusting Shape beam energy by patient's compensator 8
Normal tissue damaged；
7) collimator 9 coordinates with multi-leaf optical grating 7, obtains the homogeneous beam spot 12 consistent with lesion shape.
The present invention is not limited to above-mentioned using the method and device of wobbling magnet diffusion proton beam progress oncotherapy
Specific implementation mode, those skilled in the art can derive other implementation manners according to the technical scheme of the present invention, and also belong to this
The technological innovation scope of invention.
Claims (3)
1. a kind of device carrying out oncotherapy using wobbling magnet diffusion proton beam, it is characterized in that：Including being used to send out
The concentrating element (1) that scattered proton beam (10) is converged, for the proton beam (10) after convergence to scatter, it is made to surround
Proton center Periodic Rotating, the wobbling magnet (3) for forming a large-scale uniformly line (11), are used for scan process
The collimator (9) that uniform line (11) afterwards is adjusted and falls the proton beam card outside tumor region, passes through rotation sweep
Proton beam (10) after magnet (3) scanning, passes sequentially through energy modulator (4) and range shifter (5) respectively to proton beam
After stream energy broadening and range are adjusted, into collimator (9).
2. the device as described in claim 1 that oncotherapy is carried out using wobbling magnet diffusion proton beam, it is characterized in that：
It is equipped between the concentrating element (1) and wobbling magnet (3) for carrying out section and stream by force to the proton beam after convergence
The the first proton beam diagnostic device (2) measured.
3. the device as claimed in claim 2 that oncotherapy is carried out using wobbling magnet diffusion proton beam, it is characterized in that：
It is also equipped with successively for the proton beam after being adjusted to range shifter (5) between the wobbling magnet (3) and collimator (9)
The second proton beam diagnostic device (6) that flow section and stream measure by force, for adjusting beam spot shape on target, by tumour
Multi-leaf optical grating (7) that proton beam card outside region falls, for according to the depth of patient tumors and Adjusting Shape beam energy
Patient's compensator (8).
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610614055.0A CN106075748B (en) | 2016-07-29 | 2016-07-29 | The device of oncotherapy is carried out using wobbling magnet diffusion proton beam |
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| CN201610614055.0A CN106075748B (en) | 2016-07-29 | 2016-07-29 | The device of oncotherapy is carried out using wobbling magnet diffusion proton beam |
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| CN106075748A CN106075748A (en) | 2016-11-09 |
| CN106075748B true CN106075748B (en) | 2018-10-09 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109675072A (en) * | 2018-11-02 | 2019-04-26 | 深圳铭杰医疗科技有限公司 | A kind of line needle chlorination equipment based on magnetic field |
| CN114470535B (en) * | 2022-01-20 | 2022-12-09 | 中国原子能科学研究院 | Boron neutron capture treatment beam line layout structure |
Citations (7)
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|---|---|---|---|---|
| CN1107374A (en) * | 1994-02-26 | 1995-08-30 | 宋世鹏 | Rotary focus type radioactive therapeutic apparatus |
| US6717162B1 (en) * | 1998-12-24 | 2004-04-06 | Ion Beam Applications S.A. | Method for treating a target volume with a particle beam and device implementing same |
| CN1919373A (en) * | 2005-08-25 | 2007-02-28 | 惠小兵 | Radiation therapeutical device |
| CN1919374A (en) * | 2005-08-25 | 2007-02-28 | 惠小兵 | Radiation therapeutical irradiation device |
| WO2008011900A1 (en) * | 2006-07-27 | 2008-01-31 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Irradiation device and collimator |
| CN101778528A (en) * | 2010-03-09 | 2010-07-14 | 中国原子能科学研究院 | Method and device for high homogenization of beam current |
| CN205073541U (en) * | 2015-09-28 | 2016-03-09 | 南京中硼联康医疗科技有限公司 | A beam diagnostic system for neutron capture treatment system |
-
2016
- 2016-07-29 CN CN201610614055.0A patent/CN106075748B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1107374A (en) * | 1994-02-26 | 1995-08-30 | 宋世鹏 | Rotary focus type radioactive therapeutic apparatus |
| US6717162B1 (en) * | 1998-12-24 | 2004-04-06 | Ion Beam Applications S.A. | Method for treating a target volume with a particle beam and device implementing same |
| CN1919373A (en) * | 2005-08-25 | 2007-02-28 | 惠小兵 | Radiation therapeutical device |
| CN1919374A (en) * | 2005-08-25 | 2007-02-28 | 惠小兵 | Radiation therapeutical irradiation device |
| WO2008011900A1 (en) * | 2006-07-27 | 2008-01-31 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Irradiation device and collimator |
| CN101778528A (en) * | 2010-03-09 | 2010-07-14 | 中国原子能科学研究院 | Method and device for high homogenization of beam current |
| CN205073541U (en) * | 2015-09-28 | 2016-03-09 | 南京中硼联康医疗科技有限公司 | A beam diagnostic system for neutron capture treatment system |
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