CN106053197A - Resonance evenly mixing system and method - Google Patents
Resonance evenly mixing system and method Download PDFInfo
- Publication number
- CN106053197A CN106053197A CN201610345071.4A CN201610345071A CN106053197A CN 106053197 A CN106053197 A CN 106053197A CN 201610345071 A CN201610345071 A CN 201610345071A CN 106053197 A CN106053197 A CN 106053197A
- Authority
- CN
- China
- Prior art keywords
- resonance
- cup
- test cup
- sample
- automatic controller
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/38—Diluting, dispersing or mixing samples
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/38—Diluting, dispersing or mixing samples
- G01N2001/386—Other diluting or mixing processes
Landscapes
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Mixers With Rotating Receptacles And Mixers With Vibration Mechanisms (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
The invention provides a resonance evenly mixing system and method. The system comprises an automatic controller, a cup feeding device, which is connected to the automatic controller, a sample adding device, a resonance device, and a thermal insulation device that is connected to the resonance device. The automatic controller is used to control the cup feeding device to add test cups into the thermal insulation device. When the automatic controller receives a first confirmation command of the cup feeding device to ensure that a test cup has been placed, the automatic controller controls the sample adding device to add a sample and reagents into the test cup. When the automatic controller receives a second confirmation command indicating that the sample has been added completely, the automatic controller controls the resonance device to carry out resonance. The resonance device is used to generate a resonance force and transmits the resonance force to the thermal insulation device. The thermal insulation device can drive the test cup to carry out resonance under the action of the resonance force so as to evenly mix the sample and reagents in the test cup. Through the resonance force generated by a resonance device, a sample and reagents in a test cup can be fully and evenly mixed; the dead angle of mixing will not be generated, the structure of macromolecular enzymes will not be destroyed, and the consistency of test results can be guaranteed.
Description
Technical field
The application relates to technical field of medical instruments, particularly relates to a kind of resonance blending system and method.
Background technology
In blood coagulation tester, after needing to mix the test cup being added with sample and reagent, after mixing
Liquid is tested.In the prior art, the sample in umbrella slurry stirring-type or ultrasonic type mixing test cup and examination are generally used
Agent, but, umbrella slurry stirring-type cannot mix the stirring dead angle in test rectangle cup, therefore can be to the concordance of test result with steady
Qualitative generation affects；Ultrasonic type has great destructiveness for the structure of the macromole enzyme in sample and reagent, also can be to survey
The concordance of test result and stability produce impact.
Summary of the invention
In view of this, the application provides a kind of resonance blending system and method, to solve existing umbrella slurry stirring-type or super
Sound wave type can affect the concordance of test result and the problem of stability.
First aspect according to the embodiment of the present application, it is provided that a kind of resonance blending system, described system includes: automatically control
Device, supply cup device, sample adding device and the resonance device being connected with described automatic controller respectively are connected with described resonance device
Attemperator；
Wherein, described automatic controller, it is used for controlling described adding test cup in described attemperator for cup device；When
Receive described for cup device first confirmation instruction determine described test cup place complete after, control described sample adding device and add
Add sample and reagent in described test cup；When receive described sample adding device second confirmation instruction determine sample-adding complete it
After, drive described resonance device to carry out resonance；
Described resonance device, is used for producing resonance power and described resonance power being delivered to described attemperator；
Described attemperator, for driving described test cup resonance under the effect of described resonance power, mixes described test
Sample in Bei and reagent.
Second aspect according to the embodiment of the present application, it is provided that a kind of resonance mixing method, described method includes:
Controlled in cup device interpolation test cup to attemperator by automatic controller；
Determine that described test cup has been placed when described automatic controller receives described the first confirmation instruction for cup device
After Biing, control sample adding device and add sample and reagent in described test cup；
When described automatic controller receive described sample adding device second confirmation instruction determine sample-adding complete after, pass through
Described automatic controller drives resonance device to carry out resonance；
Produce resonance power by described resonance device and described resonance power is delivered to described attemperator；
Described attemperator drives described test cup resonance under the effect of described resonance power, mixes in described test cup
Sample and reagent.
Application the embodiment of the present application, drives resonance device to carry out resonance by automatic controller, then by this resonance device
Producing resonance power and resonance power is delivered to attemperator, attemperator drives test cup resonance under the effect of resonance power, mixed
Sample in even test cup and reagent, based on above-mentioned implementation, the resonance power produced by resonance device can be by test cup
In sample and reagent fully mix, it is not necessary to stirring rod stirring and evenly mixing sample and reagent, cross-contamination, and nothing can be avoided
Opinion is the test cup of what shape, does not all have stirring dead angle in blending process, and resonance mixing simultaneously also will not destroy big
The structure of molecule enzyme, thereby may be ensured that concordance and the stability of test result.
Accompanying drawing explanation
Figure 1A is the application structure chart according to a kind of resonance blending system shown in an exemplary embodiment；
Figure 1B is the plan structure figure of the attemperator in system shown in Figure 1A and resonance device；
Fig. 1 C is the cross section structure figure that in plan structure figure shown in Figure 1B, line B-B obtains；
Fig. 1 D is the schematic diagram that the eccentric motor in Fig. 1 C illustrated embodiment produces all directions resonance power；
Fig. 1 E is the three-dimensional structure diagram of the attemperator in Figure 1B and Fig. 1 C illustrated embodiment and resonance device；
Fig. 2 A is the application cross section structure figure according to the resonance device shown in an exemplary embodiment；
Fig. 2 B is the cross section stereo structure chart of the resonance device in Fig. 2 A illustrated embodiment；
Fig. 3 is that the application mixes the flow chart of method according to a kind of resonance shown in an exemplary embodiment；
Fig. 4 is that the application mixes the flow chart of method according to the another kind of resonance shown in an exemplary embodiment；
Fig. 5 is that the application mixes the flow chart of method according to the another kind of resonance shown in an exemplary embodiment.
Detailed description of the invention
Here will illustrate exemplary embodiment in detail, its example represents in the accompanying drawings.Explained below relates to
During accompanying drawing, unless otherwise indicated, the same numbers in different accompanying drawings represents same or analogous key element.Following exemplary embodiment
Described in embodiment do not represent all embodiments consistent with the application.On the contrary, they are only with the most appended
The example of the apparatus and method that some aspects that described in detail in claims, the application are consistent.
It is only merely for describing the purpose of specific embodiment at term used in this application, and is not intended to be limiting the application.
" a kind of ", " described " and " being somebody's turn to do " of singulative used in the application and appended claims is also intended to include majority
Form, unless context clearly shows that other implications.It is also understood that term "and/or" used herein refers to and wraps
Any or all containing one or more projects of listing being associated may combination.
Although should be appreciated that in the application possible employing term first, second, third, etc. to describe various information, but this
A little information should not necessarily be limited by these terms.These terms are only used for same type of information is distinguished from each other out.Such as, without departing from
In the case of the application scope, the first information can also be referred to as the second information, and similarly, the second information can also be referred to as
One information.Depend on linguistic context, word as used in this " if " can be construed to " ... time " or " when ...
Time " or " in response to determining ".
Figure 1A is the application structure chart according to a kind of resonance blending system shown in an exemplary embodiment, such as Figure 1A institute
Showing, this system includes: automatic controller 11, be connected with automatic controller 11 respectively for cup device 12, sample adding device 13 and
The attemperator 15 that resonance device 14 is connected with resonance device 14.
Wherein, automatic controller 11, it is used for controlling adding test cup in attemperator 15 for cup device 12；When receiving
After confirming that instruction determines that test cup placement is complete for the first of cup device 12, control sample adding device 13 adds sample and reagent arrives
In test cup；After the second confirmation instruction receiving sample adding device 13 determines that sample-adding is complete, resonance device 14 is driven to carry out
Resonance；
Resonance device 14, is used for producing resonance power and resonance power being delivered to attemperator 15；
Attemperator 15, for driving test cup resonance under the effect of resonance power, the sample in mixing test cup and examination
Agent.
In one embodiment, automatic controller 11, it is also possible to for sending shifting cup instruction to for cup device 12, and to adding
Sampling device 13 sends sample-adding instruction；For cup device 12, it is also possible to for when receiving shifting cup instruction, detecting in attemperator 15
The most still it is placed with the test cup mixed；If attemperator 15 being still placed with the test cup mixed, from attemperator
Capture the test cup mixed in 15, and the test cup mixed is placed on transmitting device；From holding test cup structure
Capture empty test cup, empty test cup is placed in the cup structure of attemperator 15；Sample adding device 13, it is also possible to be used for
When receiving sample-adding instruction, in empty test cup, add sample and reagent.
Wherein, for including microprocessor in cup device 12, grab cup structure, hold test cup structure, microprocessor exists
When receiving the shifting cup instruction that automatic controller 11 sends, detection attemperator 15 is the most still placed with the test mixed
Cup, if being still placed with the test cup mixed in attemperator 15, microprocessor controls to grab cup structure and captures the survey mixed
Test glass, and the test cup mixed is placed on transmitting device, this grabs cup structure from holding crawl sky test cup structure
Test cup, and empty test cup is placed in the cup structure of attemperator 15.
Figure 1B is the plan structure figure of the attemperator in system shown in Figure 1A and resonance device, and Fig. 1 C is to bow shown in Figure 1B
The cross section structure figure that in TV structure figure, line B-B obtains, as illustrated in figures ib and 1 c, attemperator 15 alternatively referred to as sample incubation dress
Putting, be used for simulating body temperature environment, such as 37 degrees Celsius, attemperator 15 is except including the cup structure holding test cup
151 (including multiple cup structure), it is also possible to include temperature-control circuit and heat-insulation layer 152, the specific heat capacity of heat-insulation layer is low, rigidity
Good, temperature-control circuit is maintained at 37 degrees Celsius for the temperature controlling attemperator 15.
In one embodiment, as shown in Figure 1 C, resonance device 14 can include vibrating motor 141, line slide rail 142, shakes
Galvanic electricity machine 141 may be used for being received from the first voltage signal that movement controller 11 sends, and starts under the first voltage signal drives
Rotating and produce the resonance power of all directions, line slide rail 142 may be used for the resonance power absorbing and filtering to all directions, and obtains
The resonance power axially in parallel with line slide rail 142.Additionally, resonance device 14 can also include vibrating matrix 143, vibrate matrix
The symmetrical two ends of 143 are connected with vibrating motor 141 and line slide rail 142 respectively, the other end of vibration matrix 143 and attemperator
15 connect, for the resonance power axially in parallel with line slide rail 142 is delivered to attemperator 15.
Wherein, vibrating motor 141 can be high speed eccentric motor, under the first voltage signal drives, starts to rotate and produces
The resonance power of raw all directions, Fig. 1 D is the signal that the eccentric motor in Fig. 1 C illustrated embodiment produces all directions resonance power
Figure, as shown in figure ip, the resonant frequency that high speed eccentric motor produces can be 3KHz to 5KHz, to ensure the sample in test cup
This and reagent can fully mix, and will not destroy macromole enzymatic structure.Owing to the symmetrical two ends of vibration matrix 143 connect respectively
It is connected to vibrating motor 141 and line slide rail 142, and has the insulation of attemperator 15 in the other end connection vibrating matrix 143
Layer 152, therefore, it can be filtered the resonance power absorbing all directions that vibrating motor 141 produces by line slide rail 142, finally
Obtain the resonance power axially in parallel with line slide rail 142, and through vibration matrix 143 by axially in parallel with line slide rail 142 humorous
The power of shaking is delivered to attemperator 15, and attemperator 15 drives test cup resonance under the effect of resonance power, in mixing test cup 5
Sample and reagent.
In one embodiment, the attemperator during Fig. 1 E is Figure 1B and Fig. 1 C illustrated embodiment is tied with the three-dimensional of resonance device
Composition, as referring to figure 1e, resonance blending system can also include the spring 16 that two ends symmetrical with resonance device 14 are connected respectively, from
Movement controller 11 can include that first determines unit, for determining the duration driving resonance device 14 resonance；Control unit,
For when first determines that the duration that unit determines reaches the first preset duration, stop driving resonance device 14, by bullet
The elastic force of spring 16 makes test cup stop resonance and reset；Second determines unit, is used for determining that stopping drives resonance device 14 corresponding
Time point, from second determine the second preset duration that the time point that unit determines starts after, continue executing with control for cup
Put 12 interpolation test cups to the step in attemperator 15.
Specifically, automatic controller 11 determines the duration driving vibrating motor 141 vibration, when duration reaches the
During one preset duration, automatic controller 11 controls to stop driving vibrating motor 141；At the spring 16 being positioned at resonance device 14 both sides
Elastic force effect under, test cup stops resonance and also resets；Determined that by automatic controller 11 stopping drives vibrating motor 141 right again
The time point answered；After the second preset duration that time point starts, continue executing with automatic controller 11 to for cup device 12
Send the step moving cup instruction.
Wherein, described first preset duration can be the scope of 1 to 10 seconds, and described spring 16 can include multiple disc spring,
The shape of these disc springs is identical, stiffness factor is identical, elastic modelling quantity is the most identical, these disc springs can be assembled according to involutory mode
Become two disc spring groups, after applying certain pretightning force, be separately mounted in resonance device 14 vibrate the both sides of matrix 143, when certainly
Movement controller 11 stops driving vibrating motor 141, and after the second Preset Time, test cup stops resonance and resets, described
Second Preset Time can be the scope of 5 to 10 milliseconds.
From above-described embodiment, resonance device 14 is driven to carry out resonance by automatic controller 11, then by this resonance
Device 14 produces resonance power and resonance power is delivered to attemperator 15, and attemperator 15 drives test under the effect of resonance power
Cup resonance, the sample in mixing test cup and reagent, based on above-mentioned implementation, the resonance power produced by resonance device 14 can
The sample in test cup and reagent fully to be mixed, it is not necessary to stirring rod stirring and evenly mixing sample and reagent, can avoid intersecting
Pollute, and the test cup of either what shape, blending process does not all have stirring dead angle, resonance mixes also simultaneously
The structure of macromole enzyme will not be destroyed, thereby may be ensured that concordance and the stability of test result.
In one embodiment, Fig. 2 A is the application cross section structure according to the resonance device shown in an exemplary embodiment
Figure, Fig. 2 B is the cross section stereo structure chart of the resonance device in Fig. 2 A illustrated embodiment, and resonance device 14 can include that piezoelectricity is made pottery
Porcelain agitator 144, for being received from the second voltage signal that movement controller 11 sends, starts to shake under the second voltage signal drives
Move and produce the resonance power with the centerline axis parallel of Piezoelectric Ceramic Oscillator 144；Resonance device can also include oscillating plate
Being provided with cup structure 146 on 145, and oscillating plate 145, oscillating plate 145 is for receiving Piezoelectric Ceramic Oscillator 144 transmission
With the resonance power of the centerline axis parallel of Piezoelectric Ceramic Oscillator 144, drive under the effect of resonance power and be positioned at cup structure 146
In test cup resonance, mixing test cup in sample and reagent.
Wherein, Piezoelectric Ceramic Oscillator 144 is cylindrical, and the second voltage signal sent at automatic controller 11 drives
Under, start the resonance power of vibration generation and the centerline axis parallel of this Piezoelectric Ceramic Oscillator 144, the resonance frequency of this resonance power
Rate can be 3KHz to 5KHz, to ensure that sample in test cup and reagent can fully mix, and will not destroy macromole
Enzymatic structure.
In the present embodiment, the temperature environment of the test cup in the cup structure 146 of oscillating plate 145 can be by heat radiation
Device maintains, and this temperature environment is used for simulating body temperature environment, and such as, heat radiation device maintains 37 degrees Celsius.
In one embodiment, for another example shown in Fig. 2 A and Fig. 2 B, resonance blending system can also include respectively with oscillating plate 145
The leaf spring 17 that symmetrical both sides connect.Due to, Piezoelectric Ceramic Oscillator is connected with the leaf spring 17 of oscillating plate 145 side, therefore, and piezoelectricity
Resonance power with the centerline axis parallel of this Piezoelectric Ceramic Oscillator 144 can be delivered to by ceramic resonator 144 through leaf spring 17
Oscillating plate 145, oscillating plate 145 drives the test cup resonance being positioned in cup structure 146, mixing test under the effect of resonance power
Sample in Bei and reagent, test the liquid after mixing for test device.
Additionally, automatic controller 11 determines the duration driving Piezoelectric Ceramic Oscillator 144 vibration；When duration reaches
During to the first preset duration, automatic controller 11 controls to stop driving Piezoelectric Ceramic Oscillator 144；It is being positioned at oscillating plate 145 liang
Under the elastic force effect of the leaf spring 17 of side, test cup stops resonance and resets；Stopping driving pressure being determined again by automatic controller 11
The time point of electroceramics agitator 144 correspondence；After the second preset duration that time point starts, continue executing with automatic controller
11 to the step sending shifting cup instruction for cup device 12.
From above-described embodiment, driven the Piezoelectric Ceramic Oscillator 144 in resonance device 14 by automatic controller 11
Carrying out vibrating and producing the resonance power with this Piezoelectric Ceramic Oscillator 144 centerline axis parallel, Piezoelectric Ceramic Oscillator 144 should
After the oscillating plate 145 that resonance power is delivered in resonance device 14, this oscillating plate 145 drives under the effect of resonance power and is positioned at cup
Test cup resonance in groove structure 146, the sample in mixing test cup and reagent.Based on above-mentioned implementation, filled by resonance
Sample in test cup and reagent can fully be mixed by the resonance power putting 14 generations, it is not necessary to stirring rod stirring and evenly mixing sample and
Reagent, can avoid cross-contamination, and the test cup of either what shape, does not all have stirring dead in blending process
Angle, resonance mixing simultaneously also will not destroy the structure of macromole enzyme, thereby may be ensured that concordance and the stability of test result.
Fig. 3 is that the application mixes the embodiment flow chart of method according to a kind of resonance shown in an exemplary embodiment, as
Shown in Fig. 3, this embodiment comprises the following steps:
Step 301: controlled in cup device interpolation test cup to attemperator by automatic controller；
Step 302: determine that test cup is placed complete when this automatic controller receives the first confirmation instruction for cup device
Afterwards, control sample adding device and add sample and reagent in test cup；
Step 303: when this automatic controller receives after the second confirmation instruction of sample adding device determines that sample-adding is complete, logical
Crossing this automatic controller drives resonance device to carry out resonance；
Step 304: produce resonance power by resonance device and resonance power is delivered to attemperator；
Step 305: attemperator drives test cup resonance, the sample in mixing test cup and examination under the effect of resonance power
Agent.
Flow process described in above-mentioned steps 301 to step 305 may refer to the associated description of above-mentioned Figure 1A illustrated embodiment, no
Repeat again.
In the present embodiment, drive resonance device to carry out resonance by automatic controller, then produce humorous by this resonance device
Resonance power is also delivered to attemperator by power of shaking, and attemperator drives test cup resonance, mixing test under the effect of resonance power
Sample in Bei and reagent, based on above-mentioned implementation, the resonance power produced by resonance device can be by the sample in test cup
This and reagent fully mix, it is not necessary to stirring rod stirring and evenly mixing sample and reagent, can avoid cross-contamination, and the most assorted
The test cup of shape, does not all have stirring dead angle in blending process, and resonance mixing simultaneously also will not destroy macromole enzyme
Structure, thereby may be ensured that concordance and the stability of test result.
Fig. 4 is that the application mixes the embodiment flow chart of method according to the another kind of resonance shown in an exemplary embodiment,
As shown in Figure 4, this embodiment comprises the following steps:
Step 401: controlled in cup device interpolation test cup to attemperator by automatic controller；
Automatic controller can move cup instruction to sending for cup device, for cup device when receiving the instruction of this shifting cup, and inspection
Survey in attemperator and be the most still placed with the test cup mixed, if attemperator is still placed with the test cup mixed,
By capturing, for cup device, the test cup mixed from attemperator, and the test cup mixed is placed on transmitting device
On, then for cup device from holding the test cup capturing sky test cup structure, empty test cup is placed on attemperator
In cup structure.
Step 402: determine that test cup is placed complete when this automatic controller receives the first confirmation instruction for cup device
Afterwards, control sample adding device and add sample and reagent in test cup；
Above-mentioned steps 401 and step 402, as described in step 301 and step 302, repeat no more.
Described sample can be blood plasma, if blood coagulation tester uses Chromogenic assay and carries out blood coagulation test, described
Reagent can be reaction reagent, if blood coagulation tester uses immunoturbidimetry and carries out blood coagulation test, described reagent is permissible
It it is semi-commercial (semiworks) production.
Step 403: when this automatic controller receives after the second confirmation instruction of sample adding device determines that sample-adding is complete, logical
Cross this automatic controller and send the first voltage signal to the vibrating motor being arranged in resonance device, believed by described first voltage
Number vibrating motor is driven to start to rotate and produce the resonance power of all directions；
Sample adding device, after adding sample and reagent in empty test cup, sends the second confirmation to automatic controller and refers to
Order, this automatic controller determines that sample-adding is complete, sends the first voltage signal to the vibrating motor being arranged in resonance device, pass through
First voltage signal drives vibrating motor to start to rotate and produce the resonance power of all directions.
Step 404: by resonance power absorbing and filtering to all directions of the line slide rail that is arranged in resonance device, and obtain
The resonance power axially in parallel with line slide rail；
Step 405: the resonance power axially in parallel with line slide rail is passed by the vibration matrix being arranged in resonance device
It is delivered to attemperator；
Step 406: attemperator drives test cup resonance, the sample in mixing test cup and examination under the effect of resonance power
Agent.
Flow process described in above-mentioned steps 403 to step 406 may refer to implement shown in Figure 1B, Fig. 1 C, Fig. 1 D and Fig. 1 E
The associated description of example, repeats no more.
From above-described embodiment, resonance device is driven to carry out resonance by automatic controller, then by this resonance device
Producing resonance power and resonance power is delivered to attemperator, attemperator drives test cup resonance under the effect of resonance power, mixed
Sample in even test cup and reagent, based on above-mentioned implementation, the resonance power produced by resonance device can be by test cup
In sample and reagent fully mix, it is not necessary to stirring rod stirring and evenly mixing sample and reagent, cross-contamination, and nothing can be avoided
Opinion is the test cup of what shape, does not all have stirring dead angle in blending process, and resonance mixing simultaneously also will not destroy big
The structure of molecule enzyme, thereby may be ensured that concordance and the stability of test result.
Fig. 5 is that the application mixes the embodiment flow chart of method according to the another kind of resonance shown in an exemplary embodiment,
This embodiment be after a upper embodiment mixing on the basis of, sample adding device adds a kind of reagent or chromogenic dose of starting again to
Mixed in test cup once, wherein, the immunoturbidimetry mentioned in startup reagent correspondence embodiment illustrated in fig. 4, chromogenic dose
The Chromogenic assay mentioned in corresponding embodiment illustrated in fig. 4, can be to mixing one by the mixing method in this embodiment
Secondary test cup mixes again, tests, the liquid after again mixing in test cup such as Fig. 5 institute for test device
Showing, this embodiment comprises the following steps:
Step 501: control to add test cup to the vibration being arranged in resonance device for cup device by automatic controller
In the cup structure of plate；
Step 501, as described in step 401, repeats no more, and simply supplying cup device in the present embodiment is to grab from transmitting device
Take the test cup mixed once, and sample adding device with the addition of startup reagent or chromogenic reagent in this test cup, supplies
After cup device grabs this test cup mixed once, this was mixed test cup once and had been placed on oscillating plate
In cup structure.
Step 502: determine that test cup is placed complete when this automatic controller receives the first confirmation instruction for cup device
Afterwards, send the second voltage signal by this automatic controller to the Piezoelectric Ceramic Oscillator being arranged in resonance device, pass through
Second voltage signal drives Piezoelectric Ceramic Oscillator to start vibration the generation centerline axis parallel with Piezoelectric Ceramic Oscillator
Resonance power；
Step 503: the resonance power with the centerline axis parallel of Piezoelectric Ceramic Oscillator is passed by Piezoelectric Ceramic Oscillator
It is delivered to the oscillating plate being arranged in resonance device；
Step 504: oscillating plate drives the test cup resonance being positioned in cup structure, mixing test under the effect of resonance power
Sample in Bei and reagent.
Flow process described in above-mentioned steps 502 to step 504 may refer to Fig. 2 A and the associated description of Fig. 2 B illustrated embodiment,
Repeat no more.
From above-described embodiment, the Piezoelectric Ceramic Oscillator in resonance device is driven to vibrate by automatic controller
And producing the resonance power with this Piezoelectric Ceramic Oscillator centerline axis parallel, this resonance power is delivered to humorous by Piezoelectric Ceramic Oscillator
After oscillating plate in vibrating device, this oscillating plate drives the test cup being positioned in cup structure humorous under the effect of this resonance power
Shake, the sample in mixing test cup and reagent.Based on above-mentioned implementation, the resonance power produced by resonance device can will be surveyed
Sample and reagent in test glass fully mix, it is not necessary to stirring rod stirring and evenly mixing sample and reagent, can avoid cross-contamination, and
And the test cup of either what shape, blending process does not all have stirring dead angle, resonance mixing simultaneously also will not be broken
The structure of bad macromole enzyme, thereby may be ensured that concordance and the stability of test result.Additionally, resonance device mixes at resonance
During test cup, sample adding device and confession cup device are not shut down, and sample adding device can be that the test cup on transmitting device continues
Add reagent, can continue to be placed on transmitting device the test cup mixed once for cup device, thus improve blood coagulation
The testing efficiency of tester.
Automatic controller in the embodiment of the present application can be realized by hardware circuit according to the design requirement of side circuit.Institute
The technical staff in genus field is it can be understood that arrive, for convenience and simplicity of description, and the tool of the embodiment of the method for foregoing description
Body running process, is referred to the corresponding process in aforementioned system embodiment, does not repeats them here.
One of ordinary skill in the art will appreciate that: all or part of step realizing above-described embodiment can pass through program
The hardware that instruction is relevant completes, and aforesaid program can be stored in a computer read/write memory medium, and this program is being held
During row, perform to include the step of said method embodiment；And aforesaid storage medium includes: ROM, RAM, magnetic disc or CD etc.
The various media that can store program code.
Last it is noted that above example is only in order to illustrate the technical scheme of the application, it is not intended to limit；Although
With reference to previous embodiment, the application is described in detail, it will be understood by those within the art that: it still may be used
So that the technical scheme described in foregoing embodiments to be modified, or wherein portion of techniques feature is carried out equivalent；
And these amendment or replace, do not make appropriate technical solution essence depart from the application each embodiment technical scheme spirit and
Scope.
Claims (10)
1. a resonance blending system, it is characterised in that described system includes: automatic controller, automatically control with described respectively
The attemperator being connected with described resonance device for cup device, sample adding device and resonance device that device connects；
Wherein, described automatic controller, it is used for controlling described adding test cup in described attemperator for cup device；Work as reception
After determining that the placement of described test cup is complete to described the first confirmation instruction for cup device, control described sample adding device and add sample
This and reagent are in described test cup；After the second confirmation instruction receiving described sample adding device determines that sample-adding is complete, drive
Dynamic described resonance device carries out resonance；
Described resonance device, is used for producing resonance power and described resonance power being delivered to described attemperator；
Described attemperator, for driving described test cup resonance under the effect of described resonance power, mixes in described test cup
Sample and reagent.
System the most according to claim 1, it is characterised in that
Described automatic controller, is additionally operable to send shifting cup instruction to described for cup device, and adds to the transmission of described sample adding device
Sample instructs；
Described for cup device, it is additionally operable to, when receiving the instruction of described shifting cup, detect in described attemperator and be the most still placed with
The test cup mixed；If described attemperator is still placed with the test cup mixed, capture from described attemperator
The test cup mixed, and the described test cup mixed is placed on transmitting device；Capture from holding test cup structure
Empty test cup, is placed on the test cup of described sky in the cup structure of described attemperator；
Described sample adding device, is additionally operable to, when receiving described sample-adding instruction, add sample and examination in the test cup of described sky
Agent.
System the most according to claim 1, it is characterised in that described resonance device includes: vibrating motor, line slide rail；
Wherein, described vibrating motor, for receiving the first voltage signal that described automatic controller sends, at described first voltage
Signal starts to rotate and produce the resonance power of all directions under driving；
Described line slide rail, for the resonance power absorbing and filtering to all directions, and obtains axially in parallel with described line slide rail
Resonance power；
Described resonance device also includes: vibration matrix, the symmetrical two ends of described vibration matrix respectively with described vibrating motor and institute
Stating line slide rail to connect, the other end of described vibration matrix is connected with described attemperator；
Described vibration matrix, for being delivered to described attemperator by the resonance power axially in parallel with described line slide rail.
System the most according to claim 1, it is characterised in that described system also includes symmetrical with described resonance device respectively
The spring that two ends connect；Described automatic controller includes:
First determines unit, for determining the duration driving described resonance device resonance；
Control unit, for when described first determines that the described duration that unit determines reaches the first preset duration, stops
Drive described resonance device, make described test cup stop resonance and reset by the elastic force of described spring；
Second determines unit, for determining the time point stopping driving described resonance device corresponding, determines unit from described second
After the second preset duration that the described time point determined starts, continue executing with control described confession cup device and add test cup to institute
State the step in attemperator.
System the most according to claim 1, it is characterised in that described resonance device includes: Piezoelectric Ceramic Oscillator；
Described Piezoelectric Ceramic Oscillator, for receiving the second voltage signal that described automatic controller sends, at described second electricity
Pressure signal starts the resonance power of vibration generation and the centerline axis parallel of described Piezoelectric Ceramic Oscillator under driving；
Described resonance device also includes: oscillating plate, and described oscillating plate is provided with cup structure；
Described oscillating plate, for receiving the central axis with described Piezoelectric Ceramic Oscillator of described Piezoelectric Ceramic Oscillator transmission
Parallel resonance power, drives the test cup resonance being positioned in described cup structure under the effect of described resonance power, and mixing is described
Sample in test cup and reagent.
6. the resonance mixing method being capable of the arbitrary described system of Claims 1 to 5, it is characterised in that described method
Including:
Controlled in cup device interpolation test cup to attemperator by automatic controller；
When described automatic controller receive described for cup device first confirmation instruction determine described test cup place complete it
After, control sample adding device and add sample and reagent in described test cup；
When described automatic controller receive described sample adding device second confirmation instruction determine sample-adding complete after, by described
Automatic controller drives resonance device to carry out resonance；
Produce resonance power by described resonance device and described resonance power is delivered to described attemperator；
Described attemperator drives described test cup resonance under the effect of described resonance power, mixes the sample in described test cup
And reagent.
Method the most according to claim 6, it is characterised in that described interpolation for cup device by automatic controller control is surveyed
Test glass in attemperator, including:
Described automatic controller sends shifting cup instruction to described for cup device；
Described confession cup device is when receiving the instruction of described shifting cup, and described detection in described attemperator for cup device is the most still put
It is equipped with the test cup mixed；
If described attemperator is still placed with the test cup mixed, supply cup device from described attemperator by described
Capture the test cup mixed, and the described test cup mixed is placed on transmitting device；
The test cup of described sky, from holding the test cup capturing sky test cup structure, is placed on described guarantor by described confession cup device
In the cup structure of temperature device；
Described when described automatic controller receive described for cup device first confirmation instruction determine that described test cup has been placed
After Biing, control sample adding device and add sample and reagent in described test cup, including:
Described automatic controller sends sample-adding instruction to described sample adding device；
When described sample adding device receives described sample-adding instruction, in the test cup of described sky, add sample and reagent.
Method the most according to claim 6, it is characterised in that described by described automatic controller drive resonance device enter
Row resonance, including:
The first voltage signal is sent to the vibrating motor being arranged in resonance device, by described by described automatic controller
One voltage signal drives described vibrating motor to start to rotate and produce the resonance power of all directions；
By the line slide rail that is arranged in the described resonance device resonance power absorbing and filtering to all directions, and obtain with described directly
The resonance power that line slide rail is axially in parallel；
Described produce resonance power described resonance power is delivered to described attemperator by described resonance device, including:
By the vibration matrix being arranged in described resonance device, the resonance power axially in parallel with described line slide rail is delivered to
Described attemperator.
Method the most according to claim 6, it is characterised in that described method also includes:
The duration driving the vibration of described resonance device is determined by described automatic controller；
When described duration reaches the first preset duration, control to stop driving described vibration electricity by described automatic controller
Machine；
Under being positioned at the elastic force effect of spring of described resonance device both sides, described test cup stops resonance and resets；
The time point stopping driving described resonance device corresponding is determined by described automatic controller；
After the second preset duration that described time point starts, described automatic controller continues executing with control to be added for cup device
Test cup is to the step in attemperator.
Method the most according to claim 6, it is characterised in that described by described automatic controller driving resonance device
Carry out resonance, including:
The second voltage signal is sent to the Piezoelectric Ceramic Oscillator being arranged in described resonance device by described automatic controller,
Described Piezoelectric Ceramic Oscillator is driven to start vibration and produce and described Piezoelectric Ceramic Oscillator by described second voltage signal
The resonance power of centerline axis parallel；
Described method also includes:
By described Piezoelectric Ceramic Oscillator, the resonance power with the centerline axis parallel of described Piezoelectric Ceramic Oscillator is delivered to
It is arranged on the oscillating plate in described resonance device；
Described oscillating plate drives the test cup resonance in the cup structure being positioned at described oscillating plate under the effect of described resonance power,
Mix the sample in described test cup and reagent.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610345071.4A CN106053197B (en) | 2016-05-23 | 2016-05-23 | Resonance blending system and method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610345071.4A CN106053197B (en) | 2016-05-23 | 2016-05-23 | Resonance blending system and method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106053197A true CN106053197A (en) | 2016-10-26 |
| CN106053197B CN106053197B (en) | 2021-11-12 |
Family
ID=57176585
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610345071.4A Active CN106053197B (en) | 2016-05-23 | 2016-05-23 | Resonance blending system and method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106053197B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108871922A (en) * | 2018-09-03 | 2018-11-23 | 大连技嘉科技有限公司 | Glycolated hemoglobin analysis mixes service sink with ultrasound |
Citations (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998037397A1 (en) * | 1997-02-21 | 1998-08-27 | University Of Washington | Piezo-ceramic actuator-driven mixing device |
| CN201034940Y (en) * | 2007-03-23 | 2008-03-12 | 潘本兴 | Device used for water quality detecting |
| CN101946181A (en) * | 2008-05-08 | 2011-01-12 | 株式会社日立高新技术 | Automated analyzer |
| CN203245100U (en) * | 2013-03-11 | 2013-10-23 | 无锡新慧森感知科技有限公司 | Novel resonant mode vibration machine rack |
| CN103441702A (en) * | 2013-09-23 | 2013-12-11 | 苏州大学张家港工业技术研究院 | Resonance driving mechanism based on burr friction asymmetry and robot structure |
| CN103630699A (en) * | 2013-12-06 | 2014-03-12 | 北京中勤世帝生物技术有限公司 | Thrombus elasticity measuring device |
| CN203738955U (en) * | 2014-03-03 | 2014-07-30 | 东莞市南兴家具装备制造股份有限公司 | Installation adjustment mechanism of double-end edge sealing machine |
| CN104048904A (en) * | 2014-06-23 | 2014-09-17 | 中国石油大学(华东) | Experimental device and method for testing surfactant adsorption property under resonance wave action |
| CN203881781U (en) * | 2014-05-21 | 2014-10-15 | 凯和生物科技(上海)有限公司 | Strip type immune full-automatic analyzer |
| CN104111180A (en) * | 2014-05-23 | 2014-10-22 | 苏州日和科技有限公司 | Automatic-positioning vibration sampler |
| CN104345158A (en) * | 2013-07-30 | 2015-02-11 | 苏州浩欧博生物医药有限公司 | Automatic analysis apparatus and automatic analysis method |
| US20160045918A1 (en) * | 2014-08-15 | 2016-02-18 | Counsyl, Inc. | High-throughput sample processing systems and methods of use |
-
2016
- 2016-05-23 CN CN201610345071.4A patent/CN106053197B/en active Active
Patent Citations (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998037397A1 (en) * | 1997-02-21 | 1998-08-27 | University Of Washington | Piezo-ceramic actuator-driven mixing device |
| CN201034940Y (en) * | 2007-03-23 | 2008-03-12 | 潘本兴 | Device used for water quality detecting |
| CN101946181A (en) * | 2008-05-08 | 2011-01-12 | 株式会社日立高新技术 | Automated analyzer |
| CN203245100U (en) * | 2013-03-11 | 2013-10-23 | 无锡新慧森感知科技有限公司 | Novel resonant mode vibration machine rack |
| CN104345158A (en) * | 2013-07-30 | 2015-02-11 | 苏州浩欧博生物医药有限公司 | Automatic analysis apparatus and automatic analysis method |
| CN103441702A (en) * | 2013-09-23 | 2013-12-11 | 苏州大学张家港工业技术研究院 | Resonance driving mechanism based on burr friction asymmetry and robot structure |
| CN103630699A (en) * | 2013-12-06 | 2014-03-12 | 北京中勤世帝生物技术有限公司 | Thrombus elasticity measuring device |
| CN203738955U (en) * | 2014-03-03 | 2014-07-30 | 东莞市南兴家具装备制造股份有限公司 | Installation adjustment mechanism of double-end edge sealing machine |
| CN203881781U (en) * | 2014-05-21 | 2014-10-15 | 凯和生物科技(上海)有限公司 | Strip type immune full-automatic analyzer |
| CN104111180A (en) * | 2014-05-23 | 2014-10-22 | 苏州日和科技有限公司 | Automatic-positioning vibration sampler |
| CN104048904A (en) * | 2014-06-23 | 2014-09-17 | 中国石油大学(华东) | Experimental device and method for testing surfactant adsorption property under resonance wave action |
| US20160045918A1 (en) * | 2014-08-15 | 2016-02-18 | Counsyl, Inc. | High-throughput sample processing systems and methods of use |
Non-Patent Citations (2)
| Title |
|---|
| 罗伯特•诺顿: "《机械设计》", 30 November 2015, 机械工业出版社，第5版 * |
| 黄德中: "超声波振捣器研究", 《绍兴文理学院学报》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108871922A (en) * | 2018-09-03 | 2018-11-23 | 大连技嘉科技有限公司 | Glycolated hemoglobin analysis mixes service sink with ultrasound |
Also Published As
| Publication number | Publication date |
|---|---|
| CN106053197B (en) | 2021-11-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2904616C (en) | Apparatus, cartridge and method for hemostasis testing | |
| KR100347124B1 (en) | Vibration type acturator and vibration type driving apparatus | |
| CN102670247B (en) | Ultrasonic equipment for medical diagnosis and ultrasonography production method | |
| US20160250609A1 (en) | Stirring devices | |
| US20100122586A1 (en) | Automatic analyzer and dispensing method | |
| CN102687009A (en) | Portable coagulation monitoring device and method of assessing coagulation response | |
| JP2015168016A (en) | Robot monitoring system, robot monitoring apparatus, robot monitoring method, robot monitoring module, and robot monitoring program | |
| CN106053197A (en) | Resonance evenly mixing system and method | |
| WO2011076389A1 (en) | Apparatus and method for generating a tool motion | |
| JP2020533561A (en) | Improved guided wave thermography inspection system and how to use it | |
| WO2014043251A1 (en) | Blood coagulometer and method | |
| CN209362383U (en) | A kind of blood testing oscillation oscillating uniform device | |
| CN102802777A (en) | Agitator of a liquid sample | |
| CN111269805A (en) | Vortex oscillation device | |
| CN102308218A (en) | Stirrer and analyzer | |
| CN108572221B (en) | Ultrasonic flaw detection method, ultrasonic flaw detection system, and storage medium | |
| US9956590B2 (en) | Shaker | |
| Li et al. | Design and characteristic analysis of multi-degree-of-freedom ultrasonic motor based on spherical stator | |
| CN110511921A (en) | Method and apparatus for sonicating a biological sample | |
| JPWO2006018913A1 (en) | Specimen motion control apparatus, specimen motion parameter acquisition method, and specimen motion control method | |
| CN212246984U (en) | Vortex oscillation device | |
| JP4129450B2 (en) | Transducer-based sensor system and method for performing destructive event inspection | |
| US20190033264A1 (en) | Equipment For Fatigue Testing At Ultrasonic Frequencies In The Multiaxial Regime-Axial And Torsional Directions | |
| CN209052610U (en) | A kind of multichannel Peptide synthesizer | |
| WO2023154951A1 (en) | Systems for performing acoustic measurement of batteries |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |