CN105997625A - Moistening cream for daily skin and mucosa care of children and application of moistening scream - Google Patents
Moistening cream for daily skin and mucosa care of children and application of moistening scream Download PDFInfo
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
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Abstract
The invention discloses a moistening cream for daily skin and mucosa care of children and application of the moistening scream, and belongs to the field of cosmetics. The moistening cream comprises, by weight, 1-10% of camellia-seed oil, 1-10% of avocado resin, 0.5-10% of soybean lecithin, 1-10% of triglyceride, 1-10% of bee wax, 0.5-10% of cholesterol, 1-15% of squalene or squalane, 1-15% of PCA-Na (sodium pyrrolidone carboxylate), 1-15% of sodium lactate, 1-10% of APG (alkyl polyglucoside), 1-10% of lysozyme or antimicrobial peptide, 0.1-3% of xanthan gum, 0.1-2% of lavender oil, 0.1-5% of tea polyphenol and 20-80% of deionized water. The moistening cream has the advantages that the moistening cream does not contain petrochemical materials, has the effect of moistening, smoothening and repairing skin, enhancing skin barrier function and the like and can be applied to the daily skin and mucosa care of the children.
Description
Technical field
The present invention relates to a kind of moist breast for child skin mucosa operational maintenance and application thereof, belong to cosmetic technical field.
Background technology
Child skin mucosa is fine and smooth thin tender, outermost horny layer is cell monolayer, lacking clear layer, collagen fiber in corium are rare, thin and lack flexibility, hyposteatosis, the moisture-retaining capacity of skin, Thermoregulation ability, opposing foreign body and pathogenic bacteria ability poor, easily friction is impaired and is stimulated by foreign substance and poisonous substance permeates, and mucocutaneous injury often occurs, there is mucocutaneous inflammation, the symptoms such as eczema, allergy, redness, ulcer occur.
Sebum secreted is one of main mechanism of the skin mucocutaneous barrier function of performance; sebum is to cover the ultra-thin protecting film at skin surface; make skin bright and new bright; skin surface is helped to have flexibility; alleviate the stimulation that friction produces; the natural Moisture factor (such as sodium lactate and pyrrolidone sodium carboxylate etc.) and the moisture content that prevent skin itself scatter and disappear, and skin can be protected not invaded by antibacterial or foreign substance.And child skin mucosa sebaceous gland function is not yet grown perfect, hyposteatosis.Therefore, the operational maintenance of child skin mucosa should supplement sebum, strengthens and recovers Mucocutaneous barrier function and starts with.
And child skin mucosa is fine and smooth thin tender, the petrochemical materials compositions itself such as chemical preservative conventional in cosmetics, coloring agent, essence, pigment, antibiotic, hormone, surfactant have stimulation to mucocutaneous, and readily permeable entrance is internal, upgrowth and development of children is produced long-range impact.Therefore, the cosmetics of child skin mucosa operational maintenance should be avoided selecting the chemical raw material such as oil, coal tar, should select same or analogous with the composition of skin sebum, and the compatibility with skin is good, non-stimulated, the raw material that safety is high.
Summary of the invention
An object of the present invention, is to provide a kind of moist breast for child skin mucosa operational maintenance.The moist breast of the present invention, according to bionics principle, chooses composition same or analogous with the natural constituents in sebum and skin texture, supplements child skin hyposteatosis, strengthens Mucocutaneous barrier function.
The technical scheme is that a kind of moist breast for child skin mucosa operational maintenance, including following percetage by weight raw material: Camellia oil 1～10%, shea resin 1～10%, soybean lecithin 0.5～10%, triglyceride 1～10%, Cera Flava 1～10%, cholesterol 0.5～10%, Squalene or squalane 1～15%, Anjidew NL50 1～15%, sodium lactate 1～15%, APG 1～10%, lysozyme or antibacterial peptide 1～10%, xanthan gum 0.1～3%, Oleum lavandula angustifolia 0.1～2%, tea polyphenols 0.1～5% and deionized water 20～80%.
The present invention is according to bionics principle, choose composition same or analogous with the natural constituents in sebum and skin texture, if Camellia oil, triglyceride, Cera Flava, Anjidew NL50, sodium lactate, cholesterol, Squalene or squalane, shea resin, soybean lecithin are with supplementary sebum, strengthen and recover the barrier function of child skin mucosa；Choosing the natural active matter anticorrosion such as lysozyme or antibacterial peptide, the green surfactant APG selecting safety higher carries out emulsifying；Select xanthan gum natural thickener thickening；Select Oleum lavandula angustifolia natural perfume material perfumery；Select tea polyphenols Natural antioxidant antioxidation.Meanwhile, not adding of the moist breast of the present invention is any from oil, the chemical components of coking coal, may cause the additive of untoward reaction without essence, coloring agent, chemical preservative etc..
The source of raw material of the present invention, contained main component and effect brief introduction:
Camellia oil and shea resin are vegetable oil, rich in saturated and unsaturated fatty acid, stearic acid is the solid fatty acids of plant and animal material, it is same class material with the fatty acid in people's sebum, good with skin-friendliness, have nutrition, antioxidation, moisturizing, moisten, antiallergic, antipruritic, the effect of skin protection.
Cera Flava is a kind of fatty matter of of the right age worker bee secretion, is same class material with the wax component in sebum, has plastotype, film forming, water conservation, skin anti-oxidation, bright and the effect such as hair, enhancing skin barrier.
Lecithin, triglyceride, cholesterol, Squalene or squalane are all the Life Base materials of human body, same or similar with the component in people's sebum, there is the effects such as soft and moist, gloss, promotion reparation, skin nutrition, defying age, lifting skin regeneration vigor, pitch-black hair, suppression alopecia.
Anjidew NL50, sodium lactate are that the nature moisturizing factor of human body skin and hair has the functions such as the moisturizing of uniqueness, submissive, promotion reparation, make skin be in light moisture state, prevent wrinkle from producing, improve hair quality.
APG, the i.e. abbreviation of glucoside, synthesized by Renewable resource natural fat alcohol and glucose, it it is a kind of more comprehensive new non-ionic surfactants of performance, have the characteristic of conventional nonionic and anion surfactant concurrently, there is high surface, good ecological security and intermiscibility, be internationally recognized first-selection " green " functional surfactant, instead of the synthetic surfactant to human body and environmental danger, improve the present invention and moisten the safety of breast.
Xanthan gum is natural thickener, little to the toxicity of skin and human body, and biological degradability is good, replaces the chemosynthesis thickening agent that human body and environment produce bigger harm, drastically increases the present invention and moistens the safety of breast.
Tea polyphenols is the Natural antioxidant, to skin and human non-toxic, and has defying age, smoothing wrinkle, speckle dispelling, antiinflammatory, the effect such as antibacterial.Instead of the chemosynthesis antioxidant to human body and environmental danger, improve the present invention and moisten the safety of breast.
The natural active matter such as lysozyme or antibacterial peptide is as preservative, there is bactericidal and antivirus action, and without result in the long-range misgivings of microorganism drug resistance, also there is the effect such as moisturizing, antiinflammatory, natural origin is the least to human body and dermal toxicity, drastically increases the present invention and moistens the safety of breast.
Oleum lavandula angustifolia is natural origin, has unlike bigger harm from chemically composite perfume to skin, and natural perfume material is the least to human body and dermal toxicity, and has speckle dispelling, effect of waiting for a long time antibacterial, anti-ageing, drastically increases the present invention and moistens safety and effect of breast.
Above-mentioned whole components of the present invention are the existing product of pharmaceutical grade or food stage.
On the basis of technique scheme, the present invention can also do following improvement.
Further, including the raw material of percetage by weight: Camellia oil 4%, shea resin 4%, soybean lecithin 5%, triglyceride 4%, Cera Flava 4%, cholesterol 5%, Squalene or squalane 7%, Anjidew NL50 7%, sodium lactate 7%, APG 4%, lysozyme or antibacterial peptide 4%, xanthan gum 1%, Oleum lavandula angustifolia 1%, tea polyphenols 3% and deionized water 40%.
Further, including the raw material of percetage by weight: Camellia oil 2%, shea resin 2%, soybean lecithin 2%, triglyceride 2%, Cera Flava 2.5%, cholesterol 1%, Squalene or squalane 1%, Anjidew NL50 2.5%, sodium lactate 6.5%, APG 3.5%, lysozyme or antibacterial peptide 6%, xanthan gum 0.7%, Oleum lavandula angustifolia 0.5%, tea polyphenols 1% and deionized water 66.8%.
Further, including the raw material of percetage by weight: Camellia oil 10%, shea resin 2%, soybean lecithin 5%, triglyceride 8%, Cera Flava 8%, cholesterol 2%, Squalene or squalane 5%, Anjidew NL50 5%, sodium lactate 10%, APG 5%, lysozyme or antibacterial peptide 1%, xanthan gum 0.2%, Oleum lavandula angustifolia 1%, tea polyphenols 5% and deionized water 32.8%.
Use and above-mentioned further provide the benefit that: above-mentioned raw materials is optimal parameter.Each raw material under this parameter, obtain moist breast best results.
Further, the dosage form of described moist breast is the one in unguentum, liniment, spray.
Use and above-mentioned further provide the benefit that: above-mentioned moist breast is that the moisturizing of oil water mixture, beneficially skin, reparation and active component penetrate into, and can be prepared as unguentum, liniment, spray, puts on mucocutaneous surface easily.
The two of the purpose of the present invention, are to provide the application of above-mentioned moist breast.
The technical scheme is that the application in the daily moist maintenance of child skin mucosa of a kind of moist breast as above.
The invention has the beneficial effects as follows:
(1) the moist breast that the present invention provides, according to bionics principle, chooses composition same or analogous with the natural constituents in sebum and skin texture, supplements child skin hyposteatosis, strengthens Mucocutaneous barrier function.
(2) the moist breast that the present invention provides, select and all use natural origin composition, do not contain by the source such as oil, coal tar chemical industry synthesis material, do not contain the additive such as hormone, chemical preservative, there is the advantages such as, environmental protection non-stimulated to skin, treatment and nursing efficacy are good.
(3) the moist breast that the present invention provides has moist, moisturizing, reparation, the effect such as submissive.
(4) the moist breast that the present invention provides, can be prepared as the concrete dosage form such as unguentum, liniment, spray.
(5) the moist breast that the present invention provides, can apply the daily moist maintenance of child skin mucosa.
Detailed description of the invention
Being described principle and the feature of the present invention below in conjunction with specific embodiment, example is served only for explaining the present invention, is not intended to limit the scope of the present invention.
Embodiment 1
The moist breast for child skin mucosa operational maintenance of the present embodiment, including the raw material of following weight: Camellia oil 3kg, shea resin 2kg, soybean lecithin 2kg, cholesterol 1kg, triglyceride 2kg, Cera Flava 3kg, squalane 1kg, Anjidew NL50 4kg, sodium lactate 4kg, APG 2.5kg, lysozyme 2.5kg, xanthan gum 0.5kg, Oleum lavandula angustifolia 1kg, tea polyphenols 3kg and deionized water 68.5kg.
The dosage form of above-mentioned moist breast is unguentum.
Above-mentioned moist breast, can be used for the daily moist maintenance of child skin mucosa.
Embodiment 2
The moist breast for child skin mucosa operational maintenance of the present embodiment, including the raw material of following weight: Camellia oil 1kg, shea resin 1kg, soybean lecithin 1kg, cholesterol 0.5kg, triglyceride 1kg, Cera Flava 1kg, Squalene 1kg, Anjidew NL50 1kg, sodium lactate 1kg, APG 1kg, antibacterial peptide 2.4kg, xanthan gum 0.1kg, Oleum lavandula angustifolia 2kg, tea polyphenols 5kg and deionized water 80kg.
The dosage form of above-mentioned moist breast is spray.
Above-mentioned moist breast, can be used for the daily moist maintenance of child skin mucosa.
Embodiment 3
The moist breast for child skin mucosa operational maintenance of the present embodiment, including the raw material of following weight: Camellia oil 10kg, shea resin 10kg, soybean lecithin 10kg, cholesterol 10kg, triglyceride 10kg, Cera Flava 10kg, Squalene 10kg, Anjidew NL50 3kg, sodium lactate 2.9kg, APG 1kg, antibacterial peptide 1kg, xanthan gum 0.1kg, Oleum lavandula angustifolia 1kg, tea polyphenols 1kg and deionized water 20kg.
The dosage form of above-mentioned moist breast is liniment.
Above-mentioned moist breast, can be used for the daily moist maintenance of child skin mucosa.
Embodiment 4
The moist breast for child skin mucosa operational maintenance of the present embodiment, including the raw material of following weight: Camellia oil 2kg, shea resin 2kg, soybean lecithin 2kg, triglyceride 2kg, Cera Flava 2.5kg, cholesterol 1kg, Squalene 1kg, Anjidew NL50 2.5kg, sodium lactate 6.5kg, APG 3.5kg, lysozyme 6kg, xanthan gum 0.7kg, Oleum lavandula angustifolia 0.5kg, tea polyphenols 1kg and deionized water 66.8kg.
The dosage form of above-mentioned moist breast is unguentum.
Above-mentioned moist breast, can be used for the daily moist maintenance of child skin mucosa.
Embodiment 5
The moist breast for child skin mucosa operational maintenance of the present embodiment, including the raw material of following weight: Camellia oil 10kg, shea resin 2kg, soybean lecithin 5kg, triglyceride 8kg, Cera Flava 8kg, cholesterol 2kg, squalane 5kg, Anjidew NL50 5kg, sodium lactate 10kg, APG 5kg, antibacterial peptide 1kg, xanthan gum 0.2kg, Oleum lavandula angustifolia 1kg, tea polyphenols 5kg and deionized water 32.8kg.
The dosage form of above-mentioned moist breast is liniment.
Above-mentioned moist breast, can be used for the daily moist maintenance of child skin mucosa.
Experimental example:
1, by embodiment 1 gained unguentum, carry out physical and chemical index, noxious substance limitation, Micro biological Tests, the results are shown in Table 1-3.
Table 1 physical and chemical index
Table 2 noxious substance is limited the quantity
Table 3 microbial check
2, toxicology test
(1) by made for embodiment 1 moist emulsifiable paste, according to " cosmetics safety technical specification " (version in 2015), acute ocular irritation test is carried out
1. material: select 3 adult regular grade new zealand rabbits, Medical University Of Chongqing's Experimental Animal Center provide.Single cage is raised, feed of freely drinking water, laboratory temperature: 16～24 DEG C, relative humidity: 45～65%RH.The made moist emulsifiable paste 10g of Example 1, takes filtrate after 10mL normal saline dilution.
2. test method:
Eyes inspection in 24h before test: with the hands thumb and forefinger pull open the palpebra inferior of rabbit gently, instills the fluorescein sodium diluent 2 of 2%, makes upper and lower eyelid passively close about 1s and prevent medicinal liquid from flowing out, then unclamp both hands to animal conjunctival sac, gives free rein to Guan Bi.Slowly rinse with pure water after 30s, the fluorescein sodium in eyes is rinsed well, observe after 1 hour, have no that animal eyes occurs that the monthly damage of irritation, corneal defect and knot, 3 rabbits are completely used for test.
Contamination method: with the hands thumb and forefinger pull open the palpebra inferior of eyes on the right side of rabbit gently, by every 0.1mL, the filtrate of embodiment 1 gained unguentum is directly painted in the conjunctival sac that New Zealand exempts from dimsight eye, making upper and lower eyelid passively close about 1s prevents it from flowing out, and does not rinse eyes after being painted into tested material in 24h.Left side eyes do not process makees own control.24h instills 2% fluorescein sodium diluent after observing, and cleans up after 30s.
Clinical examination and scoring: after being painted into tested material, animal eyes is checked by 1h, 24h, 48h, 72h and 4d and 7d.If 72h does not occurs irritating reaction, get final product termination test.If it find that involve cornea or have other Eye irritation effect, not recuperator in 7d, observing time need to be extended for the reversibility or irreversibility determining this infringement, be usually no more than 21d, and the visual report of 7d, 14d, 21d is provided.In addition to corneal, iris, conjunctiva are observed, other detrimental effect is all recorded faithfully.All should be by " cosmetics safety technical specification " (version in 2015) in checking every time, the integration of acute ocular zest/corrosion test table 1 " standards of grading of eye infringement " record Eye irritation reaction.
Evaluation of result: swash the top of reaction with the eye observing time point to animal corneal, iris or conjunctiva after tested material each comfortable 24h, 48h or 72h and evaluate recovery time, by " cosmetics safety technical specification " (version in 2015), acute ocular zest/corrosion test table 3 " eye excitatory reaction classification " judges the tested material stimulus intensity to eye.The results are shown in Table 4.
Table 4 tested material experiment excitatory to rabbit acute ocular appraisal result (experiment condition: do not rinse)
(2) the embodiment 1 made moist emulsifiable paste acute toxicity testing to rabbit
1. material: the white family of body weight 2.0～2.5kg exempts from, male and female half and half, is provided by Medical University Of Chongqing's animal experimental center.Use the made moist emulsifiable paste of embodiment 1.
2. test method: take healthy white rabbit 16, body weight 2.0～2.5kg, male and female half and half.The hair that family exempts from both sides, back with depilatory is sloughed, and every lateral area is 1.0 × 1.5cm2, check skin after unhairing, have damage is divided into damaged skin group.Rabbit is randomly divided into 4 groups, intact skin group, damaged skin group, normal saline integrity degree skin group, normal saline damaged skin group, often group 4.The scratch of damaged skin group rabbit skin 400# sand paper is had oozing of blood to wound surface, give the made moist emulsifiable paste of embodiment 1 and normal saline, dosage 4g/kg respectively, 1 day 3 times, wrap up with gauze.Wash away continuous 1 week of the changes such as remaining medicine, observer's rabbit skin conditions, and diet, defecation, activity, body weight with warm water after 24h.After observing 1 week, vivisection, see that the heart, liver, kidney are with or without ANOMALOUS VARIATIONS.
3. result: administration group compares with normal saline group without significant difference, and more complete group of damaged skin group rabbit skin is red, has no edema, downright bad, each group man exempts to be showed no toxic reaction, and the heart, liver, kidney have no different.
(3) the embodiment 1 made moist emulsifiable paste long term toxicity test (oral experiment) to SD rat
1. material: SD rat, 16, male and female half and half, Medical University Of Chongqing's animal experimental center provide.
2. method: SD rat 16, it is randomly divided into two groups, experimental group gavage gives embodiment 1 made moist emulsifiable paste 1g/kg/ days, divide and sooner or later pour into for twice, matched group gavage gives normal saline, successive administration 1 month, observes the situations of change such as Mus diet, defecation, activity, vivisection, observes liver, kidney with or without ANOMALOUS VARIATIONS.
3. result: experimental group compares without significant difference with matched group, each group Mus is showed no toxic reaction, and the heart, liver, kidney have no different.
3, the moistening effect evaluation of the made moist emulsifiable paste of embodiment 1
(1) some pieces of the clean glass plate of material: 7.5 × 7.5cm, 3M adhesive plaster.Reference substance is that POKO baby's baby water moistens protective skin cream.
(2) experimental technique: weigh 6 pieces of glass plate weight (M posting 3M adhesive plaster0), record respectively, 3 pieces is blank, and 3 pieces is sampling test.Take 0.2g sample to be added on the glass plate posting 3M adhesive plaster, weigh this weight M with analytical balance1(being accurate to 0.000lg), smoothens sample, and glass plate is put into dry behaviour's device of constant humidity (60%).Remaining 3 pieces of blank glass plate is put into together in the exsiccator of constant humidity.After placing 4h, 8h, take out glass plate, weigh this glass plate weight (M2), test its moisturizing rate and relative humidity rate, be immediately placed in the exsiccator of constant humidity after weighing.
Moisturizing rate computing formula: moisturizing rate=(M2-M0)/(M1-M0) × 100%
(3) experimental result (table 5): as shown in Table 5, the moistening effect in short-term of the made moist emulsifiable paste of embodiment 1 and long-acting moistening effect are with POKO baby skin protection frost quite.
The made moist emulsifiable paste of table 5 embodiment 1 and POKO reference substance are in the moisturizing rate of RH60%
Toxicology test, pharmacodynamics test prove, the moist breast of the present invention, reasonable recipe, safety non-toxic, without skin hypersensitivity, to animal normal skin and damaged skin nonirritant, there is preferable moisturizing, moisten effect, can be applicable to the daily moist maintenance of child skin mucosa.
The foregoing is only presently preferred embodiments of the present invention, not in order to limit the present invention, all within the spirit and principles in the present invention, any modification, equivalent substitution and improvement etc. made, should be included within the scope of the present invention.
Claims (6)
1. the moist breast for child skin mucosa operational maintenance, it is characterised in that include as follows
Percetage by weight raw material: Camellia oil 1～10%, shea resin 1～10%, soybean lecithin
0.5～10%, triglyceride 1～10%, Cera Flava 1～10%, cholesterol 0.5～10%, Squalene or angle
Shark alkane 1～15%, Anjidew NL50 1～15%, sodium lactate 1～15%, APG 1～10%, lysozyme or antibacterial
Peptide 1～10%, xanthan gum 0.1～3%, Oleum lavandula angustifolia 0.1～2%, tea polyphenols 0.1～5% and deionization
Water 20～80%.
A kind of moist breast for child skin mucosa operational maintenance the most according to claim 1,
It is characterized in that, including the raw material of following percetage by weight: Camellia oil 4%, shea resin 4%,
Soybean lecithin 5%, triglyceride 4%, Cera Flava 4%, cholesterol 5%, Squalene or squalane 7%, PCA
Sodium 7%, sodium lactate 7%, APG 4%, lysozyme or antibacterial peptide 4%, xanthan gum 1%, Oleum lavandula angustifolia 1%,
Tea polyphenols 3% and deionized water 40%.
A kind of moist breast for child skin mucosa operational maintenance the most according to claim 1,
It is characterized in that, including the raw material of following percetage by weight: Camellia oil 2%, shea resin 2%,
Soybean lecithin 2%, triglyceride 2%, Cera Flava 2.5%, cholesterol 1%, Squalene or squalane 1%,
Anjidew NL50 2.5%, sodium lactate 6.5%, APG 3.5%, lysozyme or antibacterial peptide 6%, xanthan gum 0.7%,
Oleum lavandula angustifolia 0.5%, tea polyphenols 1% and deionized water 66.8%.
A kind of moist breast for child skin mucosa operational maintenance the most according to claim 1,
It is characterized in that, including the raw material of following percetage by weight: Camellia oil 10%, shea resin 2%,
Soybean lecithin 5%, triglyceride 8%, Cera Flava 8%, cholesterol 2%, Squalene or squalane 5%, PCA
Sodium 5%, sodium lactate 10%, APG 5%, lysozyme or antibacterial peptide 1%, xanthan gum 0.2%, Oleum lavandula angustifolia
1%, tea polyphenols 5% and deionized water 32.8%.
5. according to a kind of described in any one of claim 1-4 for child skin mucosa operational maintenance
Moisten breast, it is characterised in that the dosage form of described moist breast is the one in unguentum, liniment, spray.
6. the moist breast as described in any one of claim 1-4 is in the daily taste of child skin mucosa
Application in profit maintenance.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108703898A (en) * | 2018-08-30 | 2018-10-26 | 广州市华晟健康产业有限公司 | A kind of children's moisturiser containing camellia |
| CN109077982A (en) * | 2018-11-01 | 2018-12-25 | 广州市华晟健康产业有限公司 | A kind of improvement infant skin barrier the effect of property lotion |
| AT520799A1 (en) * | 2018-01-09 | 2019-07-15 | Wilhelm Zsifkovits | Basic formulation for a means of animal defense |
| CN111743813A (en) * | 2020-07-07 | 2020-10-09 | 上海舒彩网络科技有限公司 | Sebum-like membrane component and preparation method thereof |
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| CN105316136A (en) * | 2015-11-09 | 2016-02-10 | 重庆琥珀茶油有限公司 | Camellia seed shampoo soap |
| CN105560131A (en) * | 2016-03-16 | 2016-05-11 | 广州丹奇日用化工厂有限公司 | Sensitive repairing type cleansing cream and preparation method thereof |
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| CN105316136A (en) * | 2015-11-09 | 2016-02-10 | 重庆琥珀茶油有限公司 | Camellia seed shampoo soap |
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| CN109077982A (en) * | 2018-11-01 | 2018-12-25 | 广州市华晟健康产业有限公司 | A kind of improvement infant skin barrier the effect of property lotion |
| CN111743813A (en) * | 2020-07-07 | 2020-10-09 | 上海舒彩网络科技有限公司 | Sebum-like membrane component and preparation method thereof |
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| CN105997625B (en) | 2018-08-28 |
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