CN105942492A - Pufanxi capsules (capsules prepared from procyanidine, lycopene, and selenium carrageenan) capable of enhancing anti-oxidation ability of cell membranes and preparation method thereof - Google Patents
Pufanxi capsules (capsules prepared from procyanidine, lycopene, and selenium carrageenan) capable of enhancing anti-oxidation ability of cell membranes and preparation method thereof Download PDFInfo
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/01—Hydrocarbons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Zoology (AREA)
- Insects & Arthropods (AREA)
- Marine Sciences & Fisheries (AREA)
- Inorganic Chemistry (AREA)
- Animal Husbandry (AREA)
- Medicines Containing Plant Substances (AREA)
- Cosmetics (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The present invention discloses Pufanxi capsules (capsules prepared from procyanidine, lycopene, and selenium carrageenan) capable of enhancing anti-oxidation ability of cell membranes and a preparation method thereof. The Pufanxi capsules (capsules prepared from procyanidine, lycopene, and selenium carrageenan) consist of the following components in weight ratios: 80-150 mg of propolis, 80-120 mg of lycopene, 70-130 mg of soybean isoflavones, 90-110 mg of procyanidine, 30-80 mg of vitamin E solution, 50-70 mg of selenium carrageenan, 20-40 mg of pearl powder, and 50-80 mg of traditional Chinese medicine powder. The preparation method comprises the following steps: the propolis is electrically crushed into powder, the remaining materials are fully mixed with the propolis powder in weight proportion, then the mixture is subjected to filling through an automatic capsule filling machine, and the vitamin E solution is then added dropwise into capsules loaded with the materials. The Pufanxi capsules (capsules prepared from procyanidine, lycopene, and selenium carrageenan) can reasonably supplement the natural antioxidant pairs of the cell membranes and improve the anti-oxidation ability of the cell membranes, so as to effectively resist the damages of the free radicals to the cells, delay the aging and inhibit the formation of the brown spots.
Description
Technical field
Health composition and preparation side's Portugal kind selenium capsule strengthening cell membrane oxidation resistance thereof of the present invention relates to a kind of defying age and preparation method thereof, belong to health food preparing technical field.
Background technology
Aging refers to organism with advancing age, a series of chronic, the change of Progressive symmetric erythrokeratodermia, degenerative that organism occurs in terms of morphosis and physiological function, the chloasma at face occurs, is commonly called as " butterfly spot ", it is simply that one of Main change.
The research that old and feeble and chloasma are carried out by scientist finds, with advancing age, the free radical in human body can gradually increase, and internal removing free radical and oxidation resistance are then gradually lowered.Internal free radical first has to attack cells film, causes cell membrane generation degeneration so that cell can not absorb nutrition from outside, also can not drain intracellular metabolic waste, and long term accumulation forms melanin, forms skin splash.It can be seen that cell membrane is the first line of defence line preventing radical damage cell.Suitably supplement the antioxidant oxidation resistance with raising cell membrane, can help to reduce the damage of radical pair cell, slow down aging, reduce mottle and formed.
Vitamin E and selenium are a kind of natural anti-oxidations pair present on cell membrane, and the character of the two is different, resist the different oxide damage to cell membrane differing mechanism, define cell and resist the natural cover for defense of radical damage.If vitamin E and selenium have any lazy weight, the oxidation resistance of cell membrane all may be reduced.Reasonable supplement antioxidant, the oxidation resistance to raising cell membrane, the damage preventing radical pair cell is very important.Although the product of the most visible multiple supplementary antioxidant, but mostly exist and natural anti-oxidation pair on cell membrane is supplemented unreasonable, consider insufficient, have even without the problem in view of cell membrane natural anti-oxidation pair, although antioxidant supplement is a lot, but get half the result with twice the effort, it is difficult to produce a desired effect.
Summary of the invention
The technical problem to be solved is: provide a kind of Portugal kind selenium capsule strengthening cell membrane oxidation resistance and preparation thereof
Method.
For solving above-mentioned technical problem, the technical solution used in the present invention is:
The present invention includes the component of following weight proportion: propolis 80-150 milligram, lycopene 80-120 milligram, soybean isoflavone 70-130 milligram, procyanidin 90-110 milligram, vitamin E solution 30-80 milligram, selenocarrageenan 50-70 milligram, Margarita powder 20-40 milligram, Chinese medicinal powder 50-80 milligram.
Preferential, the present invention includes the component of following weight proportion: propolis 100 milligrams, lycopene 100 milligrams, soybean isoflavone 100 milligrams, procyanidin 100 milligrams, vitamin E solution 50 milligrams, selenocarrageenan 50 milligrams, Margarita powder 25 milligrams, Chinese medicinal powder 75 milligrams.
Preferential, the Chinese medicinal powder that the present invention selects is that boy joins and Radix Astragali combination, and the weight ratio of the two is 1:2, i.e. 25:50 milligram.
The invention will be further described below:
Heretofore described propolis is the resin (gummy) that Apis gathers from plant spore or trunk, is mixed into palatine gland on it, a kind of jelly with aromatic odor that the secretions of wax gland processes.Propolis is opaque solid, smooth surface or coarse, and fracture is sand shape, and tangent plane is similar to marble profile, has special fragranced.Abundant contained by propolis propolis and the bioactive substance of uniqueness makes it have good antioxidation, effect of scavenging radical, and have antiinflammatory, toxin expelling, improvement circulation, endocrine regulation, promotion regeneration thus can eliminate decomposition pigmented spots, reduce wrinkle, slow down aging.
Heretofore described lycopene is a kind of natural pigment contained in plant, is primarily present in the mature fruit of plant of Solanaceae Fructus Lycopersici esculenti, and it is one of the powerful antioxidant being found in the plant of nature at present.Lycopene is removed effect of free radical and is outclassed other carotenoid materials, can eliminate free radical with effectively preventing, thus maintain cell homergy, and prevention wrinkle grows, slow down aging.
Heretofore described procyanidin is the one new and effective Natural antioxidant material extracted from Semen Vitis viniferae.It is the antioxidation found in current nature, the material that Scavenging ability is the strongest, its antioxidant activity is 50 times of vitamin E, ascorbic 20 times, the free radical that it is unnecessary in effectively removing human body, has the effect of superpower slow down aging and enhancing immunity.Procyanidin is described as " skin vitamin ", can encroach on skin by shielding of ultraviolet, hinder melanin to be formed, have astriction, tighten up skin, postpone and reduce the appearance of wrinkle of skin, prevention chloasma is formed remarkable result.
Heretofore described soybean isoflavone is the bioactive substance refined from Non-transgenic soybean, it it is a kind of natural nutrition factor with multiple important physiologically active, it it is the phytoestrogen of pure natural, easily it is absorbed by the body, can prevent women ovarian function from failing too early, reach the effect of slow down aging.Isoflavone or a kind of effective antioxidant, can stop the generation of oxygen-derived free radicals, can improve skin quality, make female skin smooth, fine and smooth, soft and smooth.
Heretofore described Margarita powder is the powder ground with produced Margaritas of shell-fish such as hydriopsis cumingii, cristaria plicata, pteria martensiis, white or be white, have the special fishy smell of Margarita.Ming Dynasty's Li Shizhen (1518-1593 A.D.) more payes attention to the pharmacological action of Margarita, it is believed that the drug effect of Margarita is at skin Caring, thus writes especially in Compendium of Material Medica: " Margarita salty in the mouth is sweet cold nontoxic, relieving palpitation point mesh；Margarita is coated with face, makes us moist good color." modern study also shows that Margarita powder is improving the aspect such as body immunity, slow down aging, freckle removing and whitening and all have the effect of uniqueness.
Heretofore described selenocarrageenan is the nutrition enhancer as Selenium Supplement element.Selenium is the ingredient of glutathione peroxidase, is maintained the function of cell membrane by Oxidation, improves the yield of the endogenous antioxidant of the lipid nature of protein.Participating in the conversion of energy, affect metabolism, emulsifying, absorption and multivitamin absorption to fat play an important role.The most also participate in and coenzyme A, the synthesis of ubiquinone, affect the function of other biological enzyme system.Amino acid whose metabolism, the synthesis of protein, carbohydate metabolism, biological oxidation are all had an impact.
Heretofore described vitamin E is a kind of fatsoluble vitamin, and its hydrolyzate is tocopherol, is one of topmost antioxidant.Can be used for preventing and treating the aspects such as climacteric syndrome, slow down aging and minimizing skin pigment formation.The vitamin E of this product is its soybean oil solution of 50%.
Vitamin E and selenium are the antioxidants that on cell membrane, a pair character is different, are to there is the natural anti-oxidation pair on cell membrane, and the two resists the different oxide damage to cell membrane to differ mechanism, defines the natural defence line resisting radical damage,.This formula, by the two connection and application, is effectively increased single application cell membrane and resists kind and the quantity of oxidant, enhance oxidation resistance.Added with vitamin E in this formula, also can produce synergism with propolis, soybean isoflavone, strengthen the biological activity being used alone.And selenium also can produce synergism with Margarita powder, lycopene, procyanidin, further enhance its antioxidation.Boy's ginseng and the Radix Astragali all belong to and are medicine and the Chinese herbal medicine of food, there is good yin nourishing QI invigorating effect, it is vitamin E and the good allied forces of this pair cell membrane natural anti-oxidation pair of selenium, can further improve the oxidation resistance of cell membrane, suppression radical pair cell or even the damage of whole body.
In the present invention, propolis, lycopene, procyanidin, soybean isoflavone have antioxidation, can effective slow down aging, Margarita powder has beauty functions, carries out compatibility with selenocarrageenan and vitamin E and makes Portugal kind selenium board and nourish beautiful capsule and have effect of functions of removing chloasma and defying age.Compatibility of the present invention is reasonable, evident in efficacy, safe and reliable, and the oxidation resistance improving cell membrane is had preferable synergism, can effectively resist the damage of radical pair cell, produces the effects such as antioxidation, defying age, antiplaque, enhancing immunity.
The present invention also provides for a kind of method prepared, and comprises the following steps:
(1) propolis is placed on 30 min low-temperature freeze dryinies in 3～10 DEG C of refrigerators, electronic is ground into powdery；
(2) Chinese medicine is cleaned drying, make the powder of 200-300 mesh with pulverizer；
(3), after propolis, lycopene, procyanidin, soybean isoflavone, selenocarrageenan, Margarita powder and Chinese medicinal powder being sufficiently mixed by weight proportion, fill is carried out by automatic capsule filling machine.
(4) according to dosage require to instill in the capsule having been charged into above-mentioned substance by vitamin E solution, then carry out conventional method encapsulation capsule.
The present invention can the natural anti-oxidation pair of reasonable supplement cell membrane, improve the oxidation resistance of cell membrane, thus effectively resist the damage of radical pair cell, slow down aging, suppression brown patch is formed.Vitamin E is added in capsule 's content by the method that employing instills, and has the plurality of advantages such as dosage is accurate, it is uniform to add, minimizing destroys, in order to be effective.
Detailed description of the invention
Embodiment 1
The present embodiment includes the component of following weight proportion: propolis 100 milligrams, lycopene 100 milligrams, soybean isoflavone 100 milligrams, procyanidin 100 milligrams, vitamin E solution 50 milligrams, selenocarrageenan 50 milligrams, Margarita powder 25 milligrams, Chinese medicinal powder 50 milligrams.
The Chinese medicinal powder selected is that boy joins and Radix Astragali combination, and the weight ratio of the two is 1:2.
The method preparing the present embodiment capsule, comprises the following steps:
(1) propolis is placed on 30 min low-temperature freeze dryinies in 3 DEG C of refrigerators, electronic is ground into powdery；
(2) Chinese medicine is cleaned drying, make the powder of 200 mesh with pulverizer；
(3) fill is carried out by automatic capsule filling machine after propolis, lycopene, procyanidin, soybean isoflavone, selenocarrageenan, Margarita powder and Chinese medicinal powder being sufficiently mixed by weight proportion.
(4) according to dosage require to instill in the capsule having been charged into above-mentioned substance by vitamin E solution again, then carry out conventional method encapsulation capsule.
Embodiment 2
The present embodiment includes the component of following weight proportion: propolis 110 milligrams, lycopene 110 milligrams, soybean isoflavone 90 milligrams, procyanidin 90 milligrams, vitamin E solution 45 milligrams, selenocarrageenan 55 milligrams, Margarita powder 40 milligrams, Chinese medicinal powder 60 milligrams.
The Chinese medicinal powder selected is that boy joins and Radix Astragali combination, and the weight ratio of the two is 1:2.
The method preparing the present embodiment capsule, comprises the following steps:
(1) propolis is placed on 30min low-temperature freeze drying in 10 DEG C of refrigerators, electronic is ground into powdery；
(2) Chinese medicine is cleaned drying, make the powder of 300 mesh with pulverizer；
(3) fill is carried out by automatic capsule filling machine after propolis, lycopene, procyanidin, soybean isoflavone, selenocarrageenan, Margarita powder and Chinese medicinal powder being sufficiently mixed by weight proportion.
(4) according to dosage require to instill in the capsule having been charged into above-mentioned substance by vitamin E solution again, then carry out conventional method encapsulation capsule.
Implementation result data:
For investigating the clinical efficacy of capsule for treating mottle of the present invention further, 39 example mottle patients are selected to carry out clinical observation on the therapeutic effect.
1, clinical data
39 example mottle female patients, all clinic cases, the age is 35-45 year, and the most all cases are provided with the clinical symptoms of mottle.
2, Therapeutic Method
Use capsule of the present invention, of the present invention capsule 4 (the most each two) be administered orally every day, continuous 85 days.
3, criterion of therapeutical effect
Cure: naked eyes disappear depending on mottle area 90%, color disappears substantially；
Effective: naked eyes disappear ＞ 60% depending on mottle area, and color is the most thin out；
Effective: naked eyes disappear 30%～60% depending on mottle cotton knot, and color is thin out；
Invalid: naked eyes disappear ＜ 30% depending on mottle area, color change is inconspicuous.
4, therapeutic effect
In 39 example patients, cure 11 examples, effective 19 examples, effective 7 examples, invalid 2 examples；Total effective rate 95%.
Compare before taking capsule, take rear experimenter serum MDA level reduce, total antioxidant capacity SOD activity improve, facial colour spot area reduces, color and luster shoals, indices experiment before and after difference all have significant.Illustrate that the capsule of the present invention has raising human body oxidation resistance, defying age, the effect of antiplaque；And it is evident in efficacy to treat mottle, has no side effect, cure rate is high.
Model case:
1. Zhang, female, 41 years old, patient facial region had butterfly spot, pigmentation to increase the weight of year by year, using multiple cosmetic effect inconspicuous, take the capsule of the present invention, within 1 month, skin of face is the finest and the smoothest, and pore attenuates, within 2 months, pigment shoals, 4 months, and mottle disappears, and facial wrinkles shoals.
2. Song, female, 32 years old, owing to lacking of proper care after childbirth, for many years, mottle is gradually become dark brown by filbert to face cyasma, area is gradually increased, invalid with multi-medicament and cosmetics, takes the capsule of the present invention, medication 20 days, complexion is transferred to ruddy by Huang, mottle desalination in 2 months, have rosy cheeks pale, drug withdrawal in 3 months, it is seen that mottle disappears, canthus fishtail line disappears, and pays a return visit and does not recurs.
Claims (4)
1. the Portugal kind selenium capsule strengthening cell membrane oxidation resistance, component including following weight proportion: propolis 80-150 milligram, lycopene 80-120 milligram, soybean isoflavone 70-130 milligram, procyanidin 90-110 milligram, vitamin E solution 30-80 milligram, selenocarrageenan 50-70 milligram, Margarita powder 20-40 milligram, Chinese medicinal powder 50-80 milligram.
Portugal kind the most according to claim 1 selenium capsule, it is characterized in that, component including following weight proportion: propolis 100 milligrams, lycopene 100 milligrams, soybean isoflavone 100 milligrams, procyanidin 100 milligrams, vitamin E solution 50 milligrams, selenocarrageenan 50 milligrams, Margarita powder 25 milligrams, Chinese medicinal powder 75 milligrams.
Portugal kind the most according to claim 1 and 2 selenium capsule, it is characterised in that Chinese medicinal powder is that boy joins and Radix Astragali combination, and the weight ratio of the two is 1:2.
4. the method preparing Portugal kind selenium capsule described in any of the above-described claim, it is characterised in that comprise the following steps:
(1) propolis is placed on 30 min low-temperature freeze dryinies in 3～10 DEG C of refrigerators, electronic is ground into powdery；
(2) Chinese medicine is cleaned drying, make the powder of 200-300 mesh with pulverizer；
(3), after propolis, lycopene, procyanidin, soybean isoflavone, selenocarrageenan, Margarita powder and Chinese medicinal powder being sufficiently mixed by weight proportion, fill is carried out by automatic capsule filling machine；
(4) according to dosage require to instill in the capsule having been charged into above-mentioned substance by vitamin E solution, then carry out conventional method encapsulation capsule.
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