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CN105833251A - Hand and foot chapping nursing composition and preparing method thereof - Google Patents

Hand and foot chapping nursing composition and preparing method thereof Download PDF

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Publication number
CN105833251A
CN105833251A CN201610288535.2A CN201610288535A CN105833251A CN 105833251 A CN105833251 A CN 105833251A CN 201610288535 A CN201610288535 A CN 201610288535A CN 105833251 A CN105833251 A CN 105833251A
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parts
pedis
care composition
rhagadia manus
interleukin
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陆东霞
赵伟
杨洪青
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Abstract

The invention discloses a hand and foot chapping nursing composition and a preparing method thereof .The hand and foot chapping nursing composition is mainly prepared from, by weight, 2-8 parts of sphingolipid, 1-5 parts of glycyrrhizin, 2-4 parts of asiaticoside, 3-6 parts of acetylsalicylic acid, 1-2 parts of theanine, 0.2-0.3 part of interleukin, 1-2 parts of oleanolic acid, 3-8 parts of sugar alcohol, 0.5-1.5 parts of beta-oxidized juglone, 3-6 parts of plant essential oil, 1-4 parts of water soluble vitamin and 3-6 parts of alginic acid .By combining the components in certain proportion, the functions of antisepsis and anti-inflammation, anti-infection, relieving swelling, pains and itching, removing necrosis, promoting granulation, promoting blood circulation, avoiding cicatrization and beautifying and nursing skin are realized, and then quick healing of chapped wounds is accelerated .The composite has a remarkable clinical treatment effect.

Description

A kind of rhagadia manus et pedis care composition and preparation method thereof
Technical field
The present invention relates to technical field, be specifically related to a kind of rhagadia manus et pedis care composition and preparation method thereof.
Background technology
Rhagadia manus et pedis refers to hand and foot xerosis cutis and the crackle caused by a variety of causes, with pain, seriously Person can affect daily life and work.Primary disease is some dermopathic simultaneous phenomenons, is also a kind of independent Dermatosis.
The reason causing rhagadia manus et pedis is broadly divided into endogenous cause of ill and exopathogenic factor, and endogenous cause of ill is that horny layer is thicker, at the palm sole of the foot etc. Position spy is thick, easily ftractures, and the palm sole of the foot is without hair follicle and sebaceous gland, and temperature is low and time humidity is less in the winter time, The skin lacking sebum protection is just susceptible to cracking；The additionally situation such as old people, ichthyosis and seborrheic keratosis, Easily causing xerosis cutis, horny layer more thickens, more susceptible disease under the influence of some extraneous factors.Exopathogenic factor is Outside brothers are exposed to, both hands often in contact with various materials, as being dried, friction, wound, it is easy to by acid, Alkali, organic solvent fat melting effect, and fungus, antibacterial etc. invade cause infection.In life, work, , easily there is chapped skin in the tractive of activities.
Rhagadia manus et pedis is apt to occur in autumn and winter season.Erythra be distributed in finger bend side, palm, heel, foot the sole of the foot outside etc. Cuticle thickening or the position often rubbed against, clinical manifestation is the depth along dermatoglyph development, different in size splitting Gap, from without any, skin lesion can feel that slight twinge or moderate are touched a tender spot, or even causalgia with hemorrhage.
The most conventional medicine includes the medicines such as external Plaster for reunion of laceration of skin, glycerol liniment, 15% carbamide ointment.As Fruit is chapped hemorrhage, the degree of causalgia, preferably with hot water by affected part maceration, make skin moisturizing, with blade by angle Matter blocked up place skiving, external used medicine the most again.But all there is the inapparent shortcoming of curative effect in existing medicine.
Summary of the invention
Present invention solves the technical problem that and be to provide a kind of rhagadia manus et pedis care composition and preparation method thereof.
The technical scheme is that a kind of rhagadia manus et pedis care composition, by weight, mainly by Following component forms: sphingolipid 2-8 part, glycyrrhizin 1-5 part, Asiaticoside 2-4 part, aspirin 3-6 part, theanine 1-2 part, interleukin 0.2-0.3 part, oleanolic acid 1-2 part, sugar alcohol 3-8 Part, beta oxidation Folium Juglandis quinone 0.5-1.5 part, plants essential oil 3-6 part, water soluble vitamins 1-4 part, algae Glue acid 3-6 part.
Further, described interleukin IL-β and interleukin 8 are by arbitrarily than the mixture of composition.
Further, described water soluble vitamins is that vitamin B1, vitamin B2 and vitamin C are by arbitrarily Mixture than composition.
Further, described plants essential oil be tea tree ethereal oil, lavandula angustifolia essence, fir essential oil, thyme oil, Cedrus deoclar (Roxb.) G. Don quintessence oil, chamomile essential oil press (3-6): (2-4.5): (2-2.5): (1-2): (1-1.8): the weight of (1-1.2) Amount is than the mixture of composition.
A kind of rhagadia manus et pedis care composition, its preparation method is:
(1) by described proportioning weigh sphingolipid, glycyrrhizin, Asiaticoside, aspirin, theanine, Interleukin, oleanolic acid, sugar alcohol, beta oxidation Folium Juglandis quinone, plants essential oil, water soluble vitamins, Algin acid；
(2) by described sphingolipid, glycyrrhizin, Asiaticoside, aspirin, theanine, interleukin 8 Element, oleanolic acid, sugar alcohol, beta oxidation Folium Juglandis quinone, plants essential oil, water soluble vitamins, algin acid mix After conjunction, stir, be crushed to 1-10 μm with supersonic jet mill, obtain admixed finepowder；
(3) described plants essential oil nebulization is uniformly sprayed on the admixed finepowder of step (2) gained, I.e. obtain rhagadia manus et pedis care composition.
Further, this care composition is prepared as ointment.
Further, the preparation method of described ointment is: weigh 20-30 part substrate, first by described hands Care composition of chapping enough joins in the substrate of 1/3, and described substrate is by simethicone, Cera Flava, Laurel Alcohol sodium sulfate forms according to the proportions of 1:4:10, grinds to form fine and smooth pasty state, adds 0.1-0.2 part and prevents Rotten agent sorbic acid, 0.1-0.2 part antioxidant gallic acid alkyl ester and the substrate of residue 2/3, continue to grind into powder Uniformly, ointment is i.e. made.
The invention has the beneficial effects as follows: in the present composition, sphingolipid is that the important composition of biofilm structure becomes Point, it is the critically important bioactive molecule of a class, they participate in regulation growths of cell, differentiation, aging and cell journey Many important signal transduction processes such as sequence is dead；Glycyrrhizin has antiinflammatory, antiallergic and protecting film knot Structures etc. act on；Asiaticoside has promotion Wound Healing, is used for treating wound, operation wound, burns, Keloid and scleroderma；Aspirin has antipyretic, analgesia, antiinflammatory, rheumatism and antiplatelet and gathers Many pharmacological actions such as collection, play drug effect rapid, and drug effect is certainly；Theanine has the merit of calmness of releiving Effect；Beta oxidation Folium Juglandis quinone has preferable antiinflammatory bactericidal action, controls wound infection；Water soluble vitamins Rehabilitation to body has important effect, appropriate vitimin supplement when of wound, contribute to wound and Time healing, moreover it is possible to provide body resistance, play pre-aseptic effect；Tea tree ethereal oil has sterilization and disappears Scorching, convergence pore, the effect for the treatment of suppurative wound, Herba Lysimachiae foenum-graeci quintessence oil can with wrinkle removal skin care, promote impaired group Knitting the function that regeneration recovers, fir essential oil can be releived pain, promotes wound healing, and thyme oil is permissible Help wound healing, treatment eczema and pimples skin quality, activating brain cell, antibacterial, spasmolytic, anti-insect poison Liquid, sterilizing, keep fit, promote the effect that scabs, Cedrus deoclar (Roxb.) G. Don quintessence oil has a significant antiinflammation, antibacterial, convergence, Diuresis, softness, reduce phlegm, antifungal, chamomile essential oil can promote the healing of the wound of inflammation, ulcer. Help improve eczema, pimples, herpes, chronic eczema, hypersensitization skin, and general allergic phenomena, calm down brokenly The blood capillary split, promotes elasticity, and strengthening tissue is splendid to being dried the skin easily itched.The above composition presses one Fixed proportioning combination, energy anti-inflammation, infection, reduces swelling and alleviating pain and pruritus, removes necrosis And granulation promoting, blood circulation promoting is avoided cicatrization, is beautified and skin nursing, thus reaches to rapidly promote chap The function of the wound healing split, clinical efficacy is notable.
Detailed description of the invention
Embodiment 1:
A kind of rhagadia manus et pedis care composition, by weight, mainly consists of the following composition: sphingolipid 2 Part, glycyrrhizin 1 part, Asiaticoside 2 parts, aspirin 3 parts, theanine 1 part, interleukin 8 Element 0.2 part, oleanolic acid 1 part, sugar alcohol 3 parts, beta oxidation Folium Juglandis quinone 0.5 part, plants essential oil 3 parts, Water soluble vitamins 1 part, algin acid 3 parts.
Wherein, described interleukin IL-β and interleukin 8 are by arbitrarily than the mixture of composition.Institute Stating water soluble vitamins is that vitamin B1, vitamin B2 and vitamin C are by arbitrarily than the mixture of composition. Described plants essential oil is tea tree ethereal oil, lavandula angustifolia essence, fir essential oil, thyme oil, Cedrus deoclar (Roxb.) G. Don quintessence oil, ocean Flos Chrysanthemi quintessence oil presses the mixture of the weight ratio composition of 3:2:2:1:1:1.
The preparation method of this rhagadia manus et pedis care composition is:
(1) by described proportioning weigh sphingolipid, glycyrrhizin, Asiaticoside, aspirin, theanine, Interleukin, oleanolic acid, sugar alcohol, beta oxidation Folium Juglandis quinone, plants essential oil, water soluble vitamins, Algin acid；
(2) by described sphingolipid, glycyrrhizin, Asiaticoside, aspirin, theanine, interleukin 8 Element, oleanolic acid, sugar alcohol, beta oxidation Folium Juglandis quinone, plants essential oil, water soluble vitamins, algin acid mix After conjunction, stir, be crushed to 1 μm with supersonic jet mill, obtain admixed finepowder；
(3) described plants essential oil nebulization is uniformly sprayed on the admixed finepowder of step (2) gained, I.e. obtain rhagadia manus et pedis care composition.
Again this care composition being prepared as ointment, preparation method is: weigh 20 parts of substrate, first by described Rhagadia manus et pedis care composition joins in the substrate of 1/3, and described substrate is by simethicone, Cera Flava, the moon Lauryl sulfate forms according to the proportions of 1:4:10, grinds to form fine and smooth pasty state, adds 0.1 part of anticorrosion Agent sorbic acid, 0.1 part of antioxidant gallic acid alkyl ester and the substrate of residue 2/3, continue to grind into powder uniformly, I.e. make ointment.
Using method: clean behind affected part with normal saline, takes appropriate ointment uniform application in affected part, 0.5g/cm2, note protecting wound no longer by secondary injury.
Embodiment 2:
A kind of rhagadia manus et pedis care composition, by weight, mainly consists of the following composition: sphingolipid 5 Part, glycyrrhizin 3 parts, Asiaticoside 3 parts, aspirin 4.5 parts, theanine 1.5 parts, the thinnest Born of the same parents' interleukin 0.25 part, oleanolic acid 1.5 parts, sugar alcohol 5.5 parts, beta oxidation Folium Juglandis quinone 1.0 parts, plant Thing quintessence oil 4.5 parts, water soluble vitamins 2.5 parts, algin acid 4.5 parts.
Wherein, described interleukin IL-β and interleukin 8 are by arbitrarily than the mixture of composition.Institute Stating water soluble vitamins is that vitamin B1, vitamin B2 and vitamin C are by arbitrarily than the mixture of composition. Described plants essential oil is tea tree ethereal oil, lavandula angustifolia essence, fir essential oil, thyme oil, Cedrus deoclar (Roxb.) G. Don quintessence oil, ocean Flos Chrysanthemi quintessence oil presses the mixture of the weight ratio composition of 4.5:3.75:2.25:1.5:1.4:1.1.
The preparation method of this rhagadia manus et pedis care composition is:
(1) by described proportioning weigh sphingolipid, glycyrrhizin, Asiaticoside, aspirin, theanine, Interleukin, oleanolic acid, sugar alcohol, beta oxidation Folium Juglandis quinone, plants essential oil, water soluble vitamins, Algin acid；
(2) by described sphingolipid, glycyrrhizin, Asiaticoside, aspirin, theanine, interleukin 8 Element, oleanolic acid, sugar alcohol, beta oxidation Folium Juglandis quinone, plants essential oil, water soluble vitamins, algin acid mix After conjunction, stir, be crushed to 5.5 μm with supersonic jet mill, obtain admixed finepowder；
(3) described plants essential oil nebulization is uniformly sprayed on the admixed finepowder of step (2) gained, I.e. obtain rhagadia manus et pedis care composition.
Again this care composition being prepared as ointment, preparation method is: weigh 25 parts of substrate, first by described Rhagadia manus et pedis care composition joins in the substrate of 1/3, and described substrate is by simethicone, Cera Flava, the moon Lauryl sulfate forms according to the proportions of 1:4:10, grinds to form fine and smooth pasty state, adds 0.15 part and prevents Rotten agent sorbic acid, 0.15 part of antioxidant gallic acid alkyl ester and the substrate of residue 2/3, continue to grind into powder uniformly, I.e. make ointment.
Using method: clean behind affected part with normal saline, takes appropriate ointment uniform application in affected part, 0.35g/cm2, note protecting wound no longer by secondary injury.
Embodiment 3:
A kind of rhagadia manus et pedis care composition, by weight, mainly consists of the following composition: sphingolipid 8 Part, glycyrrhizin 5 parts, Asiaticoside 4 parts, aspirin 6 parts, theanine 2 parts, interleukin 8 Element 0.3 part, oleanolic acid 2 parts, sugar alcohol 8 parts, beta oxidation Folium Juglandis quinone 1.5 parts, plants essential oil 6 parts, Water soluble vitamins 4 parts, algin acid 6 parts.
Wherein, described interleukin IL-β and interleukin 8 are by arbitrarily than the mixture of composition.Institute Stating water soluble vitamins is that vitamin B1, vitamin B2 and vitamin C are by arbitrarily than the mixture of composition. Described plants essential oil is tea tree ethereal oil, lavandula angustifolia essence, fir essential oil, thyme oil, Cedrus deoclar (Roxb.) G. Don quintessence oil, ocean Flos Chrysanthemi quintessence oil presses the mixture of the weight ratio composition of 6:4.5:2.5:2:1.8:1.2.
The preparation method of this rhagadia manus et pedis care composition is:
(1) by described proportioning weigh sphingolipid, glycyrrhizin, Asiaticoside, aspirin, theanine, Interleukin, oleanolic acid, sugar alcohol, beta oxidation Folium Juglandis quinone, plants essential oil, water soluble vitamins, Algin acid；
(2) by described sphingolipid, glycyrrhizin, Asiaticoside, aspirin, theanine, interleukin 8 Element, oleanolic acid, sugar alcohol, beta oxidation Folium Juglandis quinone, plants essential oil, water soluble vitamins, algin acid mix After conjunction, stir, be crushed to 10 μm with supersonic jet mill, obtain admixed finepowder；
(3) described plants essential oil nebulization is uniformly sprayed on the admixed finepowder of step (2) gained, I.e. obtain rhagadia manus et pedis care composition.
Again this care composition being prepared as ointment, preparation method is: weigh 30 parts of substrate, first by described Rhagadia manus et pedis care composition joins in the substrate of 1/3, and described substrate is by simethicone, Cera Flava, the moon Lauryl sulfate forms according to the proportions of 1:4:10, grinds to form fine and smooth pasty state, adds 0.2 part of anticorrosion Agent sorbic acid, 0.2 part of antioxidant gallic acid alkyl ester and the substrate of residue 2/3, continue to grind into powder uniformly, I.e. make ointment.
Using method: clean behind affected part with normal saline, takes appropriate ointment uniform application in affected part, 0.2g/cm2, note protecting wound no longer by secondary injury.
The clinical observation on the therapeutic effect of medicine of the present invention
1, physical data: accept out-patient's totally 86 example for medical treatment.
2, diagnostic criteria: rhagadia manus et pedis is apt to occur in autumn and winter season.Erythra be distributed in finger bend side, palm, heel, Cuticle thickening or the position that often rubs against such as outside the foot sole of the foot, clinical manifestation is the depth along dermatoglyph development, length The short crack differed, from without any, skin lesion can feel that slight twinge or moderate are touched a tender spot, or even causalgia and with Hemorrhage.According to the clinical characters of skin lesion, the most diagnosable, carry out if desired Mycology examination, antibacterial culturing and Patch test.
3, Therapeutic Method: first disease sites normal saline is cleaned up；Ointment with embodiment 2 preparation It is coated with uniformly in affected part, 2-3 time on the 1st, continuous coating 5-7 days.
4, efficacy assessment standard:
Effective: rhagadia manus et pedis symptom is fully recovered, recover normal.
Take a turn for the better: rhagadia manus et pedis disease states alleviates, and the state of an illness progressively takes a turn for the better.
Invalid: not reach improvement standard person.
5, therapeutic outcome (see table):
Total number of persons/people Effective/people Improvement/people Invalid/people Effective percentage/%
86 75 9 2 97.67
In above-mentioned treatment, by Drug therapy rhagadia manus et pedis patient 86 example of the present invention, effective 75 examples of result, Obvious effective rate is 87.21%, and take a turn for the better 2 examples, and improvement rate is 10.47%, invalid 2 examples, and total effective rate is 95.74%.
Although embodiment of the present invention are disclosed as above, but it is not restricted to description and embodiment Using listed by, it can be applied to various applicable the field of the invention completely, for being familiar with this area For personnel, it is easily achieved other amendment, is therefore being limited without departing substantially from claim and equivalency range Under fixed general concept, the present invention is not limited to specific details.

Claims (7)

1. a rhagadia manus et pedis care composition, it is characterised in that by weight, mainly by following One-tenth is grouped into: sphingolipid 2-8 part, glycyrrhizin 1-5 part, Asiaticoside 2-4 part, aspirin 3-6 Part, theanine 1-2 part, interleukin 0.2-0.3 part, oleanolic acid 1-2 part, sugar alcohol 3-8 part, Beta oxidation Folium Juglandis quinone 0.5-1.5 part, plants essential oil 3-6 part, water soluble vitamins 1-4 part, algin acid 3-6 part.
2. a kind of rhagadia manus et pedis care composition as claimed in claim 1, it is characterised in that described white thin Born of the same parents interleukin IL-β and interleukin 8 are by arbitrarily than the mixture of composition.
3. a kind of rhagadia manus et pedis care composition as claimed in claim 1, it is characterised in that described water-soluble Property vitamin be vitamin B1, vitamin B2 and vitamin C by arbitrarily than the mixture formed.
4. a kind of rhagadia manus et pedis care composition as claimed in claim 1, it is characterised in that described plant Quintessence oil is tea tree ethereal oil, lavandula angustifolia essence, fir essential oil, thyme oil, Cedrus deoclar (Roxb.) G. Don quintessence oil, chamomile essential oil The mixture formed by a certain percentage.
5. a kind of rhagadia manus et pedis care composition as claimed in claim 1, it is characterised in that preparation method For:
(1) by described proportioning weigh sphingolipid, glycyrrhizin, Asiaticoside, aspirin, theanine, Interleukin, oleanolic acid, sugar alcohol, beta oxidation Folium Juglandis quinone, plants essential oil, water soluble vitamins, Algin acid；
(2) by described sphingolipid, glycyrrhizin, Asiaticoside, aspirin, theanine, interleukin 8 After element, oleanolic acid, sugar alcohol, beta oxidation Folium Juglandis quinone, water soluble vitamins, algin acid mixing, stirring Uniformly, it is crushed to 1-10 μm with supersonic jet mill, obtains admixed finepowder；
(3) described plants essential oil nebulization is uniformly sprayed on the admixed finepowder of step (2) gained, I.e. obtain rhagadia manus et pedis care composition.
The preparation method of a kind of rhagadia manus et pedis care composition the most as claimed in claim 5, it is characterised in that This care composition is prepared as ointment.
The preparation method of a kind of rhagadia manus et pedis care composition the most as claimed in claim 5, it is characterised in that The preparation method of described ointment is: weigh 20-30 part substrate, first by described rhagadia manus et pedis care composition Join in the substrate of 1/3, grind to form fine and smooth pasty state, add 0.1-0.2 part preservative, 0.1-0.2 Part antioxidant and the substrate of residue 2/3, continue to grind into powder uniformly, i.e. make ointment.
CN201610288535.2A 2016-05-03 2016-05-03 Hand and foot chapping nursing composition and preparing method thereof Pending CN105833251A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108014033A (en) * 2018-01-04 2018-05-11 湖北瑞晟生物有限责任公司 The sufficient essential oil of one kind shield and its preparation process

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Publication number Priority date Publication date Assignee Title
CN1943545A (en) * 2006-10-17 2007-04-11 王海龙 Cosmetics composite and its preparing method and use
CN101322750A (en) * 2008-06-04 2008-12-17 张小平 Novel use of Cistanche tubulosa extract
CN101795732A (en) * 2007-04-19 2010-08-04 玫琳凯有限公司 Magnolia extract containing compositions
CN103961615A (en) * 2014-05-23 2014-08-06 梁亮 Traditional Chinese medicine composition for treating rhagadia manus and pedalis and preparation thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1943545A (en) * 2006-10-17 2007-04-11 王海龙 Cosmetics composite and its preparing method and use
CN101795732A (en) * 2007-04-19 2010-08-04 玫琳凯有限公司 Magnolia extract containing compositions
CN101322750A (en) * 2008-06-04 2008-12-17 张小平 Novel use of Cistanche tubulosa extract
CN103961615A (en) * 2014-05-23 2014-08-06 梁亮 Traditional Chinese medicine composition for treating rhagadia manus and pedalis and preparation thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108014033A (en) * 2018-01-04 2018-05-11 湖北瑞晟生物有限责任公司 The sufficient essential oil of one kind shield and its preparation process

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Application publication date: 20160810