CN105816344B - 一种含有吡咯并喹啉醌和n-乙酰基神经氨酸的组合物 - Google Patents
一种含有吡咯并喹啉醌和n-乙酰基神经氨酸的组合物 Download PDFInfo
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- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
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- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7012—Compounds having a free or esterified carboxyl group attached, directly or through a carbon chain, to a carbon atom of the saccharide radical, e.g. glucuronic acid, neuraminic acid
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
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Abstract
本发明涉及一种组合物，含有吡咯并喹啉醌或其盐和N‑乙酰基神经氨酸，其中吡咯并喹啉醌或其盐和N‑乙酰基神经氨酸的重量比为1∶1‑10，最优选吡咯并喹啉醌或其盐和N‑乙酰基神经氨酸的重量比为1∶5.5，所述的组合物具有很好的抗氧化效果，可以应用化妆品和食品中。
Description
技术领域
本发明涉及一种组合物，具体涉及一种含有吡咯并喹啉醌和N-乙酰基神经氨酸的组合物。
背景技术
吡咯并喹啉醌(PQQ)是最早从微生物发现的小分子化合物，在高等真核生物体内也有存在。PQQ是生物体的能力获得体系中必需的氧化还原的辅酶，可以从各种生物中提取。PQQ的生物活性已经进行了大量的研究，迄今为止已经发现的PQQ的生物活性有：提高人体免疫功能、防治肝损伤、减少自由基、调理神经系统疾病、促进氨基酸的吸收、促进合成生长因子、促进合成谷胱甘肽、抗癌、抗过敏等，PQQ的外用作用有：抗氧化、紫外线吸收、防止皮肤老化、防止光老化、除去活性氧作用等，上述用途使其广泛应用于药品、化妆品、食品等多个领域。吡咯并喹啉醌已经被提出具有成为新的维生素的可能性。
PQQ是一种水溶性化合物，通常以红褐色粉末状存在，PQQ的结构式如下：
燕窝是人们常用的美容保健食品，其中含有多种具有生物活性的化合物，N-乙酰基神经氨酸即为其中的一种，N-乙酰基神经氨酸是一种天然存在的氨基酸糖类的碳水化合物，最初由颌下腺粘蛋白中分离而出，也因此命名为唾液酸。迄今为止已经发现的N-乙酰基神经氨酸的生物活性有：提高婴儿智力和记忆力、抗老年痴呆、抗识别、提高肠道对维生素及矿物质的吸收、抗菌排毒和抗病毒等作用。
N-乙酰基神经氨酸是一种水溶性化合物，通常以白色粉末状存在，N-乙酰基神经氨酸的结构式如下：
含有吡咯并喹啉醌的组合物已经被广泛研究，中国专利CN103458865A公开了一种含有吡咯并喹啉醌和表面活性剂且pH为4-6的外用组合物，可以提高组合物的保存稳定性。中国专利CN102688155A公开了一种含有吡咯并喹啉醌、EDTA和醇的外用组合物，具有优异的弹性蛋白酶活性抑制作用。中国专利CN102793632A公开了一种含有吡咯并喹啉醌和肽的外用组合物，用于改善皮肤粗糙和改善皱纹。
N-乙酰基神经氨酸的应用也被文献所报道，中国专利CN104586642A公开了N-乙酰基神经氨酸在个人护理用品中的应用，具有消炎抑菌，促进细胞修复的功效。中国专利CN104998292A公开了N-乙酰基神经氨酸在卫生用品中的应用，具有抗炎美白的功效。中国专利CN104083291A公开了N-乙酰基神经氨酸在化妆品中的应用，具有保湿、美白、消炎、抗老化的功效。日本专利JP平1-163110A公开了N-乙酰基神经氨酸作为皮肤老化预防剂的应用。
吡咯并喹啉醌的抗氧化作用已经被应用于药品、食品和化妆品领域，但是目前还没有文献报道N-乙酰基神经氨酸具有抗氧化作用，本发明人在研究过程中出乎意料地发现，吡咯并喹啉醌和N-乙酰基神经氨酸组合后的抗氧化作用产生了协同作用，比单独使用吡咯并喹啉醌或N-乙酰基神经氨酸的抗氧化作用要好很多，从而完成了本发明。
发明内容
本发明的一个目的是提供一种组合物。
本发明提供了一种组合物，其特征在于，所述组合物含有吡咯并喹啉醌或其盐和N-乙酰基神经氨酸。
本发明提供了一种组合物，其特征在于，组合物中吡咯并喹啉醌或其盐和N-乙酰基神经氨酸的重量比为1∶1-10。
优选地，本发明的组合物中吡咯并喹啉醌或其盐和N-乙酰基神经氨酸的重量比为1∶3-7。
更优选地，本发明的组合物中吡咯并喹啉醌或其盐和N-乙酰基神经氨酸的重量比为1∶1，1∶5.5或1∶10。
最优选地，本发明的组合物中吡咯并喹啉醌或其盐和N-乙酰基神经氨酸的重量比为1∶5.5。
本发明的吡咯并喹啉醌的盐为吡咯并喹啉醌的无机盐或有机盐，例如无机盐为钠或钾等碱金属盐、钙或镁等碱土金属盐、铵盐，有机盐为三乙醇胺或三乙胺等有机胺盐，赖氨酸或精氨酸等碱性氨基酸盐。优选吡咯并喹啉醌的盐为钠盐或钾盐。上述吡咯并喹啉醌的盐可以单独使用，也可以2种以上组合使用。
本发明的另一个目的是提供上述组合物在制备抗氧化剂的用途。
本发明的另一个目的是提供一种化妆品组合物，其特征在于，所述化妆品组合物含有吡咯并喹啉醌或其盐和N-乙酰基神经氨酸。
本发明的化妆品组合物可以加入化妆品领域可接受的辅料，所述化妆品领域可接受的辅料为：溶剂、增溶剂、防腐剂、pH调节剂、促渗剂、脂质体、保湿剂、增稠剂、螯合剂、肤感调节剂、表面活性剂、乳化剂、推进/抛射剂、香精或/和色素，所述化妆品组合物为香皂、洗面奶、沐浴露、柔肤水、护肤啫喱、护肤乳液、护肤霜、精华液、眼霜、面膜、睫毛膏或唇膏，制成气雾或喷雾形式。
本发明的另一个目的是提供一种食品，其特征在于，所述食品含有吡咯并喹啉醌或其盐和N-乙酰基神经氨酸。
本发明的食品可以加入食品领域可接受的辅料，所述食品领域可接受的辅料为：增稠剂、稳定剂、乳化剂、护色剂、金属络合剂、营养强化剂、防腐剂、着色剂、漂白剂、膨松剂、酸度调节剂、组织改良剂、抗结剂、酶制剂、增味剂或/和食用香料，所述食品为固态或液态形式。
以化妆品组合物或食品的总重量计算，本发明的组合物占上述化妆品组合物或食品的总重量的0.1％-1％，优选0.3％-0.5％。
具体实施方式
下面结合实施例对本发明作进一步的详细说明，但本发明的实施方式不限于此。下述实施例中所用方法如无特别说明均为常规方法。
实施例1：取吡咯并喹啉醌10g和N-乙酰基神经氨酸10g，溶于1000mL蒸馏水，制备成溶液。
实施例2：取吡咯并喹啉醌10g和N-乙酰基神经氨酸55g，溶于1000mL蒸馏水，制备成溶液。
实施例3：取吡咯并喹啉醌10g和N-乙酰基神经氨酸100g，溶于1000mL蒸馏水，制备成溶液。
对比例1：取吡咯并喹啉醌10g，溶于1000mL蒸馏水，制备成溶液。
对比例2：取N-乙酰基神经氨酸10g，溶于1000mL蒸馏水，制备成溶液。
对比例3：取N-乙酰基神经氨酸55g，溶于1000mL蒸馏水，制备成溶液。
对比例4：取N-乙酰基神经氨酸100g，溶于1000mL蒸馏水，制备成溶液。
实施例4：抗氧化效果实验：采用清除DPPH·自由基法测定吡咯并喹啉醌和N-乙酰基神经氨酸的抗氧化作用。
测定DPPH·清除能力的方法：精确称取0.0122gDPPH·溶于无水乙醇中，然后用50％乙醇溶液定容于50mL容量瓶，作为母液冷藏备用，用移液管准确量取10mL母液定容于100mL棕色瓶，得到浓度为0.0244mg/mL的工作液。准确量取一系列不同量的待测液，分别加入10mL比色管中，各加入浓度为0.0244mg/mL的DPPH·溶液2.5mL，用50％乙醇定容至5mL，室温静置反应20分钟后，在517nm处测定吸光度.因体系内DPPH·的浓度与其吸光度成正比，所以可以直接以下式计算待测液对DPPH·的清除率.物质对DPPH·的清除率越高，说明该物质的抗氧化能力越强。
清除率的计算公式如下：清除率(％)＝(A0-A)/A0×100％，其中A0为未加待测液时测定的DPPH·溶液的吸光度；A为加入待测液后测定的DPPH·溶液的吸光度。通过测定实施例1-3和对比例1-4的清除率，结果如表1所示。
表1本发明组合物的协同清除作用
由表1的实验结果可知，吡咯并喹啉醌和N-乙酰基神经氨酸的组合对于DPPH·的清除率均大于二者在添加浓度下清除率的代数和，说明吡咯并喹啉醌和N-乙酰基神经氨酸之间存在抗氧化协同作用，可以利用抗氧化剂的协同作用，组合使用抗氧化剂，提高抗氧化效果。
Claims (9)
1.一种组合物，其特征在于，所述组合物含有吡咯并喹啉醌或其盐和N-乙酰基神经氨酸，其中吡咯并喹啉醌或其盐和N-乙酰基神经氨酸的重量比为1∶1-10。
2.根据权利要求1所述的组合物，其特征在于，吡咯并喹啉醌或其盐和N-乙酰基神经氨酸的重量比为1∶3-7。
3.根据权利要求1所述的组合物，其特征在于，吡咯并喹啉醌或其盐和N-乙酰基神经氨酸的重量比为1∶1，1∶5.5或1∶10。
4.根据权利要求1所述的组合物，其特征在于，吡咯并喹啉醌或其盐和N-乙酰基神经氨酸的重量比为1∶5.5。
5.根据权利要求1-4任一项所述的组合物，其特征在于，吡咯并喹啉醌的盐为吡咯并喹啉醌的无机盐或有机盐。
6.根据权利要求5所述的组合物，其特征在于，吡咯并喹啉醌的无机盐为钠盐或钾盐。
7.权利要求1-6任一项所述的组合物在制备抗氧化剂的用途。
8.一种化妆品组合物，其特征在于，所述化妆品组合物含有权利要求1-6任一项所述的组合物。
9.一种食品，其特征在于，所述食品含有权利要求1-6任一项所述的组合物。
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