CN105794883B - A kind of rose Chinese medicine composition for removing dust mite and its preparation method and application - Google Patents
A kind of rose Chinese medicine composition for removing dust mite and its preparation method and application Download PDFInfo
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- CN105794883B CN105794883B CN201610171708.2A CN201610171708A CN105794883B CN 105794883 B CN105794883 B CN 105794883B CN 201610171708 A CN201610171708 A CN 201610171708A CN 105794883 B CN105794883 B CN 105794883B
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/40—Liliopsida [monocotyledons]
- A01N65/46—Stemonaceae [Stemona family], e.g. croomia
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Abstract
The invention belongs to biomedicine field, and in particular to a kind of rose Chinese medicine composition for removing dust mite and its preparation method and application.The rose Chinese medicine composition contains rose, Jasmine, peppermint oil, the tuber of stemona and sandliving sophora seed.The rose Chinese medicine composition has the effect of removing dust mite, can be applied in the medicine for killing acarid is prepared.
Description
Technical field
The invention belongs to biomedicine field, and in particular to a kind of rose Chinese medicine composition for removing dust mite and its preparation side
Method and application.
Background technology
Various anaphylactogens cause mankind's allergic diseases.It is known, for example, that house dust can draw for a long time
The allergic reaction disease of the mankind is sent out, such as asthma and allergic rhinitis.Early in nineteen twenty-eight, foreign countries have reported that dust mite is that dust is led
The main reason for causing allergic reaction.
Dust mite belongs to the microarthropods of spider shape net on taxology, and its shape has 8 pin like spider, individual atomic
Small, only 170-500 microns are long, and human eye is not easy to find.Only it is a few with the related mite of people's anaphylactoid reaction, such as
Dermatophagoides pteronyssinus, dust mite and euroglyphus maynei etc..Dust mite is widely distributed, dermatophagoides pteronyssinus mainly multiply in the pillow in bedroom, cotton-padded mattress by, cushion and
In furniture.Dust mite can also largely multiply on the ground of flour mill, cotton mill and food warehouse, Chinese medicine warehouse etc..Dust mite is one
Kind nibbles the spontaneous mite of feeding habits, using powdery material as food, such as animal scurf, flour, cottonseed cake and fungi.The excretion of dust mite
Catabolite of thing, secretion and dead polypide etc. is all anaphylactogen, and the sensitization of wherein faecal pellet is most strong.Above-mentioned excreta is divided
Solve as molecule, by the activities such as folded quilt, housecleaner of making the bed, fly upward dust, allergic constitution person induces super quick after sucking
Reaction.
Numerous studies confirm that dust mite and bronchial astehma are in close relations, and New Zealand scholar has carried out more than ten years to asthmatic children
Follow-up study, it was confirmed that dust mite drastically influence the incidence of disease of asthma as a kind of independent dangerous sensitizing agent, the U.S.
Three investigation also confirm dust mite in succession and cat hair, cockroach are the important risk factors for inducing bronchial astehma, and dust mite is to induce
The important allergen of the allergic diseases such as bronchial astehma.
Allergy common clinical manifestation caused by dust mite is mainly asthma and allergic rhinitis, the incidence of disease in children liken to
It is artificial high, it is about more than half in patient to be fallen ill before 12 years old.1987 so far, has held for several times about dust mite allergy and branch
The international symposium of san bronchial asthma relation, a large amount of bases about dust mite allergy asthma and clinical progress are reported,
But the Main Preventive Measures taken at present the disease are：1. often cleaning dedusting, diligent washed, diligent to shine bed clothes mattress；2. keep
Room ventilation drying, few dirt；3. using acaricide, such as Buddhist nun's pa is net, Actellic and Benzyl Benzoate fat.These measure only parts
The environment of dust mite existence is eliminated, acaricide has certain side effect to human body in addition to having killing action to dust mite, substantially
Can not dedusting, depositing dust, except mite.For diseases such as the asthma caused by dust mite allergy or allergic rhinitises, at present still without ideal
Treatment method, generally can use dust mite immersion liquid carry out desensitization injection, make body produce immunological tolerance, so as to mitigate symptom and
The breaking-out of disease is reduced, can not be cured completely.
For above-mentioned prior art, the present invention now provides a kind of rose Chinese medicine composition for removing dust mite, the rose Chinese medicine
Composition has the effect of removing dust mite, can be with by carrying out heating the occupation mode that steam is stifling, is sprayed in air indoors
Kill acarid.Present invention simultaneously provides the preparation method and application of the rose Chinese medicine composition.
The content of the invention
It is an object of the invention to provide a kind of rose Chinese medicine composition for removing dust mite.
It is a further object to provide the application of above-mentioned rose Chinese medicine composition.
It is a further object to provide the preparation method of above-mentioned rose Chinese medicine composition.
Above-mentioned purpose of the present invention is achieved through the following technical solutions：
A kind of rose Chinese medicine composition for removing dust mite, the rose Chinese medicine composition contain rose, Jasmine, peppermint
Oil, the tuber of stemona and sandliving sophora seed.
It is a kind of remove dust mite rose Chinese medicine composition, the rose Chinese medicine composition contain following weight than component：
Rose 10-20 parts, Jasmine 10-20 parts, peppermint oil 0.1-5 parts, tuber of stemona 5-20 parts, the sub- 5-20 parts of sandliving sophora seed.
The rose Chinese medicine composition can be applied in the medicine for preparing prevention allergic diseases.
The rose Chinese medicine composition can be applied in the medicine for killing acarid is prepared.
Wherein, the medicine be carry out heating indoors steam is stifling, sprayed in air by way of use.
Rose Chinese medicine composition of the present invention also contains emulsifying agent.
Wherein, the emulsifying agent is 1-10 parts according to weight ratio.
The emulsifying agent is dodecyl sodium sulfate.
A kind of preparation method for the rose Chinese medicine composition for removing dust mite, the preparation method are as follows：
1. adding distilled water 100ml into rose, 80 DEG C decoct distillation, and concentrate distillate to 10ml, are prepared
Rose wate decocting liquid；
2. Jasmine, the tuber of stemona, sandliving sophora seed are decocted 20-40 minutes for 100 DEG C in 2000ml distilled water, it is small that standing puts 24
When, filter paper filtering, 90ml is concentrated into, the rose wate decocting liquid being prepared in adding 1., pharmaceutical aqueous solution is made；
3. adding emulsifying agent into peppermint oil, stir while adding, it is to be mixed uniformly after be slowly added to 2. in obtained medicine
The thing aqueous solution, stirring produce affiliated rose Chinese medicine composition, are sealed to mixing.
The invention provides a kind of rose Chinese medicine composition for removing dust mite, the prescription of said composition with reference to plurality of medical
Pharmacological basis, it is nontoxic to human body：
Peppermint oil：This product is colourless or flaxen supernatant liquid.There is special refrigerant fragrance, it is pungent, rear cool at the beginning of taste.Fragrance
Medicine, remedium corrigens and carminative.Refrigerant sense being produced available for skin or mucous membrane to mitigate to be not suitable for, fish mint has Qinghuo Jiedu,
The effect of desinsection is antipruritic.
Rose：Rose sweet and slightly bitter taste, slightly warm in nature, Return liver, spleen, stomach.Rose contains abundant natural complex
C, protein, mineral matter etc..Beautifying skin-protection function with highly significant, energy whitening effect, soft skin, smooths microgroove, in advance
Anti-wrinkle, skin regeneration can be promoted, make skin keep elasticity and gloss.Activate, stimulate circulation, improve spleen function, profit
Spleen invigorating heart.Rose has certain antibacterial, bacteria resistance function simultaneously.
Jasmine：Jasmine have qi-regulating and in, open it is strongly fragrant ward off it is dirty.Cure mainly the diseases such as diarrhea stomachache, red eye, swell pain, sore swollen toxin
Disease.Volatilization oily matter contained by Jasmine has the effect of promoting qi circulation and relieving pain, the strongly fragrant dissipating bind of solution, anti-inflammation.
The tuber of stemona：Sweet, bitter, the tepor of property.Return lung passes through.Moisten the lung and relieve the cough；Desinsection and delousion.For the head louse of enterobiasis and people, animal, body
Lice etc..
Sandliving sophora seed：This product such as beans, ellipse, long 3~5mm, surface pink or reddish yellow are alternate, smooth, push up sometimes
End has white membranoid substance, and hilum point-like, indent, lower section is extended with a dark colour line.Matter is hard, kind skin separation, cotyledon
Yellow.Taste is extremely bitter.Sandliving sophora seed is a kind of Tibetan medicine, is mainly used in diphtheria disease, icteric hepatitis, suppurative tonsillitis, parasitosis
Treatment, wherein alkaloid has antibacterial, disinsection efficiency.
Emulsifying agent：Lauryl sodium sulfate, belong to anion surfactant, there is good emulsification, foaming, permeate, go
Dirty and dispersive property, is widely used in toothpaste, shampoo, hair cream, shampoo, washing powder, liquid are washed, the demoulding of cosmetics and plastics,
The industry such as lubrication and pharmacy, papermaking, building materials, chemical industry.
The beneficial effects of the present invention are：
1st, a kind of rose Chinese medicine composition for removing dust mite provided by the invention, reasonable recipe, compatibility is without taboo, to human body
It is free of toxic effects.The environment of dust mite life can be not only eliminated, effectively kills dust mite, moreover it is possible to destroy the allergy such as various excretas
Original, especially to there is allergic constitution, but do not induce and excite hypersensitivity person to have prevention effect, eliminate the reaction of its dust mite allergy,
Prevent allergic diseases.
2nd, the rose Chinese medicine composition provided by the invention for removing dust mite can be fumigated by heating steam, be sprayed in air
Mode be distributed in space, active area is big, and dead angle is few, can effectively destroy various excretas, eliminate dust mite.
Embodiment
Embodiment 1：Remove the preparation method of the rose Chinese medicine composition of dust mite
Reagent：10% lauryl sodium sulfate, Shanghai Sheng Gong bioengineering limited company；
1. rose 20g adds distilled water 100ml, 80 DEG C decoct distillation, and concentrate distillate to 10ml, and rose is prepared
The rare aqueous solution.
2. by tuber of stemona 20g, Jasmine 20g, the sub- 20g of sandliving sophora seed 100 DEG C of decoction 20-40 minutes in 2000ml distilled water,
Standing is put 24 hours, filter paper filtering, is concentrated into 90ml, is added the above-mentioned rose aqueous solution 1. prepared, obtain pharmaceutical aqueous solution；
3. peppermint oil 5ml, 10ml emulsifying agents (10% lauryl sodium sulfate) are added, stirs while adding, is slowly added to
Above-mentioned pharmaceutical aqueous solution 2., mixing is slowly stirred, produces rose Chinese medicine composition, be sealed.
Embodiment 2：Remove the preparation method of the rose Chinese medicine composition of dust mite
Reagent：10% lauryl sodium sulfate, Shanghai Sheng Gong bioengineering limited company；
1. rose 15g adds distilled water 100ml, 80 DEG C decoct distillation, and concentrate distillate to 10ml, and rose is prepared
The rare aqueous solution.
2. by tuber of stemona 10g, Jasmine 15g, the sub- 15g of sandliving sophora seed 100 DEG C of decoction 20-40 minutes in 2000ml distilled water,
Standing is put 24 hours, filter paper filtering, is concentrated into 90ml, is added the above-mentioned rose aqueous solution 1. prepared, obtain pharmaceutical aqueous solution.
3. peppermint oil 1ml, adding 2ml emulsifying agents (10% lauryl sodium sulfate), stirring while adding, slowly add afterwards
Enter above-mentioned pharmaceutical aqueous solution 2., be slowly stirred mixing, produce rose Chinese medicine composition, be sealed.
Embodiment 3：Remove the preparation method of the rose Chinese medicine composition of dust mite
Reagent：10% lauryl sodium sulfate, Shanghai Sheng Gong bioengineering limited company；
1. rose 10g adds distilled water 100ml, 80 DEG C decoct distillation, and concentrate distillate to 10ml, and rose is prepared
The rare aqueous solution.
It is 2. Jasmine 10g, the sub- 5g of sandliving sophora seed 100 DEG C of decoction 20-40 minutes in 2000ml distilled water, quiet by tuber of stemona 5g
Put 24 hours, filter paper filtering, be concentrated into 90ml, add the above-mentioned rose aqueous solution 1. prepared, obtain pharmaceutical aqueous solution.
3. peppermint oil 0.1ml, 1ml emulsifying agents (10% lauryl sodium sulfate) are added, are stirred while adding, afterwards slowly
Above-mentioned pharmaceutical aqueous solution 2. is added, is slowly stirred mixing, rose Chinese medicine composition is produced, is sealed.
Embodiment 4：Remove the application method of the rose Chinese medicine composition of dust mite
During using rose Chinese medicine composition, 200ml water can be added in rose Chinese medicine composition, by spraying or heating steaming
The stifling mode of vapour makes rose Chinese medicine composition scattered in a room, maintenance 30 minutes, in triplicate.
Embodiment 5：The effect of rose Chinese medicine composition for removing dust mite, is verified
The present embodiment is removed the effect of rose Chinese medicine composition of dust mite and verified, is the bubble chamber simulation with good seal performance
The experimental verification that room environment is carried out, obtains preferable effect.
1st, reagent
10% lauryl sodium sulfate, Shanghai Sheng Gong bioengineering limited company；
Recombinant dust mite allergen Der P1 albumen, ProSpec-Tany Techno Gene Ltd；
ELISA kit, ProSpec-Tany Techno Gene Ltd.
2nd, simulated experimental environments：
Preservative film is fixed using the bubble chamber of 7 30cm × 40cm × 30cm good seal performances, and in its bottom, it is determined that
3.5g dust mixture (containing 0.2 microgram recombinant dust mite allergen Der P1 albumen), after 200 mesh sieve are sieved through, by dust
After mixture is uniformly applied on fixed preservative film, medicine composite preparation in rose is sprayed.
3rd, experimentation：
After dust mixture is uniformly applied on fixed preservative film, medicine composite preparation in rose is sprayed respectively, maintains 9 every time
Hour.After end, dust mixture is collected, adds 800 microlitres of distilled water, 3000 leave the heart 15 minutes, and take supernatant to be tried with ELISA
The content of agent box check weighing group dust mite allergen Der P1 albumen, so as to analyze destruction of the rose Chinese medicine composition to dust mite allergen
And reduce degree.
4th, experimental group is set：
Blank control group：Distilled water.
Rose control group：Rose 20g adds distilled water 100ml, and 80 DEG C decoct distillation, produce rose control group,
It is sealed.
The sub- control group of the tuber of stemona+sandliving sophora seed：Tuber of stemona 20g, the sub- 20g of sandliving sophora seed 100 DEG C of decoction 20-40 in 1000ml distilled water
Minute, standing is put 24 hours, filter paper filtering, is concentrated into 100ml, is produced the sub- control group of the tuber of stemona+sandliving sophora seed, be sealed.
Peppermint oil control group：Peppermint oil 5ml, 10ml emulsifying agents (10% lauryl sodium sulfate) are added, stirred when adding
Mix, be slowly added to 100ml distilled water afterwards, be slowly stirred mixing, produce peppermint oil control group, be sealed.
Rose Chinese medicine composition high dose group：Prepare such as embodiment 1.
Rose Chinese medicine composition middle dose group：Prepare such as embodiment 2.
Rose Chinese medicine composition low dose group：Prepare such as embodiment 3.
Percentage=(blank control group-experimental group)/blank control group of recombinant dust mite allergen Der P1 albumen reductions
× 100%, wherein, the percentage of recombinant dust mite allergen Der P1 albumen reductions, which compares so as to see who is superior, represents recombinant dust mite allergen Der P1
The reduction degree of albumen.
The recombinant dust mite allergen Der P1 albumen of table 1 reduces degree
Rose Chinese medicine composition reduces degree to restructuring dust mite allergen Der P1 albumen and is shown in Table 1.Through rose Chinese traditional medicine composition
After thing sprinkling, significantly reducing (P ＜ 0.05) in dust mixture, the reduction degree of recombinant dust mite allergen Der P1 albumen reaches
To 46.9%~86.7%, rose Chinese medicine composition is notable to the reduction or destructiveness for recombinating dust mite allergen Der P1 albumen
Better than peppermint oil control group, the sub- control group of the tuber of stemona+sandliving sophora seed and rose control group, wherein, high dose group and middle dose group
Most pronounced effects, reduction degree respectively reach 60.1% and 86.7%.
Rose Chinese medicine composition can be decreased or even eliminated by destroying or adsorbing recombinant dust mite allergen Der P1 albumen
Dust mite allergen in dust, the rose Chinese medicine composition is prompted to be answered in the medicine for preparing prevention allergic diseases
With, also can prepare kill acarid medicine in apply.
Claims (8)
1. a kind of rose Chinese medicine composition for removing dust mite, it is characterised in that the rose Chinese medicine composition is by following weight ratio
Component composition：Rose 15-20 parts, Jasmine 15-20 parts, peppermint oil 1-5 parts, tuber of stemona 10-20 parts, the sub- 15-20 of sandliving sophora seed
Part.
2. application of the rose Chinese medicine composition as claimed in claim 1 in the medicine for preparing prevention allergic diseases.
3. application of the rose Chinese medicine composition as claimed in claim 1 in the medicine for killing acarid is prepared.
4. application as claimed in claim 3, it is characterised in that the medicine be by carry out heating indoors steam it is stifling,
What the mode sprayed in air used.
5. the rose Chinese medicine composition of dust mite is removed as claimed in claim 1, it is characterised in that the rose Chinese medicine composition
Also contain emulsifying agent.
6. the rose Chinese medicine composition of dust mite is removed as claimed in claim 5, it is characterised in that the emulsifying agent is according to weight
Than for 1-10 parts.
7. the rose Chinese medicine composition of dust mite is eliminated as claimed in claim 5, it is characterised in that the emulsifying agent is dodecane
Base sodium sulfonate.
8. a kind of preparation method of the rose Chinese medicine composition as claimed in claim 5 for removing dust mite, it is characterised in that described
Preparation method is as follows：1. adding distilled water l00ml into rose, 80 DEG C decoct distillation, and concentrate distillate to l0ml, prepare
Obtain rose wate decocting liquid；2. Jasmine, the tuber of stemona, sandliving sophora seed are decocted into 20-40 minutes for 100 DEG C in 2000ml distilled water,
Standing is put 24 hours, filter paper filtering, is concentrated into 90rnl, the rose wate decocting liquid being prepared in adding 1., it is water-soluble that medicine is made
Liquid；3. adding emulsifying agent into peppermint oil, stir while adding, it is to be mixed uniformly after be slowly added to 2. in obtained medicine it is water-soluble
Liquid, stirring produce affiliated rose Chinese medicine composition, are sealed to mixing.
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| CN201610171708.2A CN105794883B (en) | 2016-03-24 | 2016-03-24 | A kind of rose Chinese medicine composition for removing dust mite and its preparation method and application |
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| CN110338197A (en) * | 2019-07-31 | 2019-10-18 | 西藏阿木达草本科技有限公司 | A kind of plant type disinfecting mite-removing element and preparation method |
| CN111838203A (en) * | 2020-07-20 | 2020-10-30 | 华玫科技集团有限公司 | Cloud rose aromatherapy disinfection spray and preparation method thereof |
| CN115500361A (en) * | 2022-09-27 | 2022-12-23 | 上海家化联合股份有限公司 | Water-based product containing peppermint leaf oil and mite killing application thereof |
| CN118415197A (en) * | 2024-04-25 | 2024-08-02 | 广州云丽生物科技有限公司 | Herbal mite-killing stock solution and application thereof |
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| CN1085247A (en) * | 1993-05-22 | 1994-04-13 | 周行 | Bedding cleaning spray |
| GB2407981A (en) * | 2003-11-15 | 2005-05-18 | Reckitt Benckiser | Method of deactivating allergens |
| GB2410897A (en) * | 2004-02-13 | 2005-08-17 | Reckitt Benckiser | Method of deactivating allergens such as dust mites |
| CN101632391A (en) * | 2008-07-25 | 2010-01-27 | 刘志刚 | Development of novel indoor acaricide |
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