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CN105770436A - 一种用于烧伤烫伤的软膏 - Google Patents

一种用于烧伤烫伤的软膏 Download PDF

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CN105770436A
CN105770436A CN201610154693.9A CN201610154693A CN105770436A CN 105770436 A CN105770436 A CN 105770436A CN 201610154693 A CN201610154693 A CN 201610154693A CN 105770436 A CN105770436 A CN 105770436A
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herba
radix
rhizoma
ointment
parts
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许笑笑
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Hangzhou Fuyang Feibo Technology Co Ltd
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Hangzhou Fuyang Feibo Technology Co Ltd
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Abstract

本发明涉及一种用于烧伤烫伤的软膏，其采用的原料药为：虎杖、紫草、茯苓、藏红花、五倍子、甘草、紫花地丁、连翘、败酱草、鱼腥草、半枝莲、蒲公英、白花蛇舌草、山慈菇、蚤休、侧柏叶、栀子、白芷、黄柏、刘寄奴、白芨、艾叶、牡丹皮、赤芍、熟地、三七、白术、红花、川芎、王不留行、舒筋草、蒺藜，将药物有效成分粉碎过筛后制备膏剂，本发明软膏清热燥湿、消肿止痛，活血通络，对烧伤烫伤效果显著，应用前景广阔。

Description

一种用于烧伤烫伤的软膏
技术领域
本发明属于中药药物技术领域，具体的，涉及一种用于烧伤烫伤的软膏。
背景技术
烧伤烫伤是一种严重危害人们身体健康的常见意外创伤，烧伤或者烫伤的程度不同，致伤的轻重不一，轻的损伤皮肤,重的损伤肌肉，再重的损伤筋骨。无论轻重的烧烫伤，本身都是火毒或热毒，如治疗不当造成伤面感染或会迫毒内攻，甚至会发展成败血症、脓毒败血症或破伤风。烧伤烫伤历来是难以治疗的疑难病症，烧伤的程度由温度的高低、作用时间的长短而不同，局部的变化可分为四度：第一度：因血管麻痹而充血；第二度：形成充满血清的烧伤水疱；第三度：组织坏死；第四度：组织的炭化。烧伤时可见血液中的乳酸量增加，动静脉血的pH值降低，随着组织毛细血管功能障碍的加重，缺氧血症也严重。
不论是传统还是现代的中医中药治疗烧伤的方法或处方，一般都停留在秘方阶段，并未形成切实的药品产品，很容易使传统的秘方失传而使我们中华医药的宝贵财富流失，本发明人针对上述情况，潜心研究中医中药治疗烧伤的机理。中医关于烧伤有着深厚的理论基础，中医认为烧伤亦称火烧疮、汤泼火烧、汤火伤。轻浅者通常不影响内脏功能，仅在局部出现红晕，起疱，或腐烂；重者损害面积大而深，产生火盛伤阴，热毒炽甚，耗伤体内阴液。甚则热毒内攻，或气血两虚等全身症状，临床可见口渴，发热，便秘，小便不利甚或烦躁不宁，神昏谵语。治疗轻者只需外治，用地榆、大黄等量，冰片少许研末，香油调敷。重者宜辨证施治，清热解毒，凉营熄风，或固气养阴，回阳救逆，多选用黄连解毒汤、犀角地黄汤、羚羊钩藤汤或生脉散、参附汤等加味，若病程日久，耗伤气血者，则宜补气养血，可用八珍汤加味。外治方法包括清洗疮面，水泡处理，清除焦痂或植皮等项，亦可将上述药膏涂敷疮面，严重者应及时进行中西医抢救治疗。
目前针对烧伤烫伤的治疗，一般采用西医或者外敷药，但是它们往往没有消炎的功能，而且与西药的消炎抗菌适应性较差，容易造成表面愈合内部仍然在发炎的现象，导致病人的伤口久治不愈，时好时坏。在以往的皮肤表皮烧、烫伤治疗过程中，治愈周期很长，用药过程患者十分痛苦，并且容易留下疤痕，影响美观。
多数治疗烧伤烫伤的药物治疗效果并不十分理想，部分药物治疗周期较长，或每天需要的用药量次数多，给患者带来诸多不便，另外就是有的药物患者不能在室外走动，限制了患者的活动量，抑或在药物中加入过多的化学成分，对患者的身体造成潜在的危害。
发明内容
本发明的目的在于提供一种治疗烧烫伤的药物组合物及其制备方法，本申请的发明人结合祖传秘方根据前人经验及自己多年的医疗实践，通过对传统中药的研究，并结合辩证论证，多方收集众家之长，以中医外治为主，寻求最佳治疗方案，采用纯天然中草药原料，结合传统中医技术精心配制成本发明的治疗烧伤的药物组合物，该中药组合物不仅对烧伤烫伤处治愈周期短，为患者带来方便，另外，该组合物治愈率高，无毒副作用。
为实现本发明目的，本发明采用的技术方案如下：
一种用于烧伤烫伤的软膏，其由下述重量配比的原料制作而成：
虎杖20-25份、紫草20-25份、茯苓20-25份、藏红花20-25份、五倍子20-22份、
甘草20-22份、紫花地丁18-20份、连翘18-20份、败酱草18-20份、鱼腥草18-20份、
半枝莲15-18份、蒲公英15-18份、白花蛇舌草15-18份,山慈菇15-18份、蚤休15-18份、
侧柏叶12-15份、栀子12-15份、白芷12-15份、黄柏12-15份、刘寄奴12-15份、
白芨10-12份、艾叶10-12份、牡丹皮10-12份、赤芍10-12份、熟地10-12份、
三七5-8份、白术5-8份、红花5-8份、川芎5-8份、王不留行5-8份、
舒筋草3-5份、蒺藜3-5份。
所述软膏的制备方法为：按照上述重量份数称取各原料药
（1）取虎帐、藏红花、败酱草、鱼腥草、半枝莲、侧柏叶、白芨、三七、川芎按所述比例混合，加相对于混合物2倍重量95%的乙醇，回流提取2次，每次1小时，提取液合并，浓缩至密度为1.2g/ml的清膏，80℃烘干，粉碎成粉末，即为复合物A；
(2)取剩余原料药加5倍重量水煎煮两次，第一次2小时，第二次1小时，合并两次滤液，将滤液减压干燥获得密度为1.2g/ml的浸膏，80℃烘干后，粉碎成粉末，即为复合物B；
(3)均匀混合复合物A和复合物B获得药粉，将药粉与麻油按重量比1:1.5拌合搅匀，经红外线灯灭菌后，装入无菌器皿内密封保存。用时取药软膏涂于经清理或消毒过的伤面上。
注意事项：治疗期间避免食用辛辣刺激以及光敏感性的食物，如辣椒、牛、羊肉、鱼虾、海鲜、芹菜、香菜、白萝卜、芒果、酱油、酒类等，避免引起发炎感染、色素沉着及促使疤痕增生。要多食用蔬菜及易消化的食品，以补体内气血两虚和增加营养，控制和预防感染，增强体内活性蛋白、微生素等营养与免疫力。以提高身体及肌肤机能加速愈伤组织的愈合，有利于皮肤尽快恢复正常，防止外伤疤痕。并可结合服用维生素C、维生素E，每次各100毫克。一日三次，可以减少因药物（外用内服）等治疗外伤过程中色素的沉着，促进康复。
本发明药物的组分均采用天然的中药原料，其配制简便，药源广泛，成本低廉，其遵循中医的处方用药原则，诸药合用，相得益彰，药性平和，其具备如下效果：
1)减少渗出，保护创面，促进创面愈合，愈合后疤痕少；
2)使用方法简单，每天换药的次数少，给患者带来很多方便，且不需要与其他抗菌素结合治愈周期短，见效快；
3)在普通的环境即可治疗，没有无菌环境的要求，制备方法简单，成本低，可以进行规模性生产。未出现毒副作用，应用前景广阔。
具体实施方式
实施例1
一种用于烧伤烫伤的软膏，其由下述重量配比的原料制作而成：
虎杖20份、紫草20份、茯苓20份、藏红花20份、五倍子20份、
甘草20份、紫花地丁18份、连翘18份、败酱草18份、鱼腥草18份、
半枝莲15份、蒲公英15份、白花蛇舌草15份,山慈菇15份、蚤休15份、
侧柏叶12份、栀子12份、白芷12份、黄柏12份、刘寄奴12份、
白芨10份、艾叶10份、牡丹皮10份、赤芍10份、熟地10份、
三七5份、白术5份、红花5份、川芎5份、王不留行5份、
舒筋草3份、蒺藜3份。
所述软膏的制备方法为：按照上述重量份数称取各原料药
（1）取虎帐、藏红花、败酱草、鱼腥草、半枝莲、侧柏叶、白芨、三七、川芎按所述比例混合，加相对于混合物2倍重量95%的乙醇，回流提取2次，每次1小时，提取液合并，浓缩至密度为1.2g/ml的清膏，80℃烘干，粉碎成粉末，即为复合物A；
(2)取剩余原料药加5倍重量水煎煮两次，第一次2小时，第二次1小时，合并两次滤液，将滤液减压干燥获得密度为1.2g/ml的浸膏，80℃烘干后，粉碎成粉末，即为复合物B；
(3)均匀混合复合物A和复合物B获得药粉，将药粉与麻油按重量比1:1.5拌合搅匀，经红外线灯灭菌后，装入无菌器皿内密封保存。用时取药软膏涂于经清理或消毒过的伤面上。
实施例2
一种用于烧伤烫伤的软膏，其由下述重量配比的原料制作而成：
虎杖25份、紫草25份、茯苓25份、藏红花25份、五倍子22份、
甘草22份、紫花地丁20份、连翘20份、败酱草20份、鱼腥草20份、
半枝莲18份、蒲公英18份、白花蛇舌草18份,山慈菇18份、蚤休18份、
侧柏叶15份、栀子15份、白芷15份、黄柏15份、刘寄奴15份、
白芨12份、艾叶12份、牡丹皮12份、赤芍12份、熟地12份、
三七8份、白术8份、红花8份、川芎8份、王不留行8份、
舒筋草5份、蒺藜5份。
所述软膏的制备方法为：按照上述重量份数称取各原料药
（1）取虎帐、藏红花、败酱草、鱼腥草、半枝莲、侧柏叶、白芨、三七、川芎按所述比例混合，加相对于混合物2倍重量95%的乙醇，回流提取2次，每次1小时，提取液合并，浓缩至密度为1.2g/ml的清膏，80℃烘干，粉碎成粉末，即为复合物A；
(2)取剩余原料药加5倍重量水煎煮两次，第一次2小时，第二次1小时，合并两次滤液，将滤液减压干燥获得密度为1.2g/ml的浸膏，80℃烘干后，粉碎成粉末，即为复合物B；
(3)均匀混合复合物A和复合物B获得药粉，将药粉与麻油按重量比1:1.5拌合搅匀，经红外线灯灭菌后，装入无菌器皿内密封保存。用时取药软膏涂于经清理或消毒过的伤面上。
实施例3
动物学实验
药理药效学试验
一、本发明局部用药毒理学
研究大鼠破损皮肤表面给药的急性毒性试验
大鼠皮肤毒性试验用最大浓度（药效学最佳浓度的30倍）给药一次。给药后观察7天，和对照组比较，受试组大鼠既未出现死亡又未出现明显中毒反应。说明本发明制剂经破损皮肤表面给药毒性极低。
兔皮肤刺激试验
用新西兰白兔完整皮肤和破损皮肤进行多次性（连续涂药7天）刺激试验，按《新药（西药）临床前研究指导原则汇编（药学、药理学、毒理学）》评分。结果表明：多次给药结束后，在对照区与受试区比较观察，皮肤刺激反应强度均＜0.5分，多次给药期间也未观察到皮肤红斑、水肿等刺激反应。表明本发明软膏多次给药（7天）对兔完整皮肤和破损皮肤均无刺激性。
实施例4
临床病例
1.本组病人133例，其中住院病人78例占58.6％，门诊病人55例占41.4％。年龄最大61岁，最小12岁。烧伤常见原因：(1)开水烫伤，(2)火烧伤，(3)热气流冲击伤，(4)化学物质烧伤，如硫酸，石灰水，(5)沥青烫伤等。
诊断证明：烧伤部位，四肢烧伤77例占57.9％；头面部烧伤29例占21.8％；躯干27例占20.3％。
烧伤面积及深度：I度烧伤53例，最大面积占全身面积21.3％；浅II度烧伤44例，深II度烧伤23例；III度烧伤13例。
2.治疗方法
对于刚烧伤的新鲜创面，入院后给以用碘伏或碘络酮液消毒，并清除创面上的污物，有水泡低位剪破放出积液，保留泡皮。游离或皱折的坏死腐皮予以清除，清除干净后再消毒一次。涂敷本发明得实施例1制备的中药物膏剂，24小时换药一次，连续换药3次，每次换药时应给予创面清创。
3.治疗结果
本组133例，I度烧伤53例，3-4天内全部愈合。浅II度烧伤44例，深II度烧伤23例，6～15天愈合。III度烧伤13例，20～42天愈合。早期入院的II度-III度病人经清创包扎或暴露治疗，没有出现因炎性反应而影响愈合。晚期入院的II度-III度病人，因烧伤局部出现感染组织液化痂下或痂下积脓，虽经彻底清创，局部组织氧化，但仍出现炎性病变影响愈合。本组仅有3例III度烧伤的病人虽经清创周边缘皮肽爬生再生修复而自行愈合，但仍留有条状疤痕。临床追访半年II度以上患者，没有其他不适。
典型病例
张某，男，31岁，沸水烫伤，伤口处红肿，起泡，患处面积3×6cm，给予实施例2制备的软膏后，4天后痊愈，且烫伤处不留疤痕，患者在敷药的过程中，没有疼痛感和其它不适感。
以上列举的仅是本发明的最佳具体实施例。显然，本发明不限于以上实施例，还可以有许多变形。本领域的普通技术人员能从本发明公开的内容直接导出或联想到的所有变形，均应认为是本发明的保护范围。

Claims (4)

1.一种用于烧伤烫伤的软膏，其由下述原料制备而成：
虎杖、紫草、茯苓、藏红花、五倍子、甘草、紫花地丁、连翘、败酱草、鱼腥草、
半枝莲、蒲公英、白花蛇舌草、山慈菇、蚤休、侧柏叶、栀子、白芷、黄柏、刘寄奴、
白芨、艾叶、牡丹皮、赤芍、熟地、三七、白术、红花、川芎、王不留行、舒筋草、蒺藜。
2.根据权利要求1所述的软膏，其特征在于其由下述重量配比的原料制作而成：
虎杖20-25份、紫草20-25份、茯苓20-25份、藏红花20-25份、五倍子20-22份、
甘草20-22份、紫花地丁18-20份、连翘18-20份、败酱草18-20份、鱼腥草18-20份、
半枝莲15-18份、蒲公英15-18份、白花蛇舌草15-18份、山慈菇15-18份、蚤休15-18份、侧柏叶12-15份、栀子12-15份、白芷12-15份、黄柏12-15份、刘寄奴12-15份、
白芨10-12份、艾叶10-12份、牡丹皮10-12份、赤芍10-12份、熟地10-12份、
三七5-8份、白术5-8份、红花5-8份、川芎5-8份、王不留行5-8份、
舒筋草3-5份、蒺藜3-5份。
3.权利要求1-2所述的软膏，其特征在于，所述软膏的制备方法为：
按照上述重量份数称取各原料药；
（1）取虎帐、藏红花、败酱草、鱼腥草、半枝莲、侧柏叶、白芨、三七、川芎按所述比例混合，加相对于混合物2倍重量95%（体积比）的乙醇，回流提取2次，每次1小时，提取液合并，浓缩至密度为1.2g/ml的清膏，80℃烘干，粉碎成粉末，即为复合物A；
(2)取剩余原料药加5倍重量水煎煮两次，第一次2小时，第二次1小时，合并两次滤液，将滤液减压干燥获得密度为1.2g/ml的浸膏，80℃烘干后，粉碎成粉末，即为复合物B；
(3)均匀混合复合物A和复合物B获得药粉，将药粉与麻油按重量比1:1.5拌合搅匀，即得。
4.权利要求1-3所述软膏的用途。
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CN106236951A (zh) * 2016-08-23 2016-12-21 徐峥 一种治疗烧烫伤及术后疤痕的中药组合物
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CN108938837A (zh) * 2017-05-20 2018-12-07 朱西发 一种治疗烫伤的药物组合物及其制备方法

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Application publication date: 20160720