CN105770034A - Chinese herbal preparation for treating femoral head necrosis and preparing method and application thereof - Google Patents
Chinese herbal preparation for treating femoral head necrosis and preparing method and application thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/36—Caryophyllaceae (Pink family), e.g. babysbreath or soapwort
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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Abstract
The invention discloses a Chinese herbal preparation for treating femoral head necrosis and a preparing method and application thereof.The Chinese herbal preparation is prepared from, by weight, 15-25 parts of radix ranunculi ternate, 3-10 parts of Magnolia amoena Cheng, 8-16 parts of Japonese pearlwort herb and 1-8 parts of cassia twig.Radix ranunculi ternate and Japonese pearlwort herb are smashed, screened and mixed, deionized water is added to be boiled with strong fire, decoction is conducted with slow fire, and then soaking is conducted to obtain a mixture A; Magnolia amoena Cheng and cassia twig are smashed, screened and mixed, ethyl alcohol of 75% is added, and heat treatment and ultrasonic treatment are conducted to obtain a mixture B; the mixture A is mixed with the mixture B to be subjected to ultrasonic treatment, heat stirring treatment, centrifugal separation and drying, so that the Chinese herbal preparation is prepared.Under the synergistic effect of all the raw materials, the functions of promoting urination and eliminating humidity, relieving swelling and internal heat or fever, eliminating phlegm and dredging collaterals, tonifying qi, liver and kidney, strengthening spleen and stomach and promoting coronary circulation are realized, femoral head necrosis can be effectively treated, cure time is short, cure rate is 86% or more, effective rate can reach 100%, no toxic or side effect is caused, relapse does not occur after cure, and the Chinese herbal preparation is worth wide clinical application and popularization.
Description
Technical field
The present invention relates to pharmaceutical technology field, a kind of Chinese medicine preparation treating femur head necrosis and preparation method thereof and should
With.
Background technology
Femur head necrosis is that blood supply of the femoral head interrupts or impaired, causes osteocyte and marrow components death and reparation subsequently, continues
And cause the disease of femoral head structural change, collapse of the femoral head, joint function disturbance.Femur head necrosis is also known as ischemic femoral head
Property downright bad, be the common refractory disease of field of orthopaedics.The femur head necrosis cause of disease is outer two kinds: a kind of generation is at neck of femur
Reduction of the fracture poor healing, the weight-bearing trabeculae in femoral head turns to heavy burden area carrier stress reduction, stress damage occurs,
So necrosis always occurs in patients with fractures's healing, after walking with load.Another kind is osseous tissue self pathological changes, as most common
Chronic alcoholism or use the osteonecrosis that causes of glucocorticoid, the Regeneration and Repair impairment of osseous tissue simultaneously.In addition
Also include childhood development growth stage femoral head germinal center-femoral head epiphyseal necrosis, also known as Femoral Head Necrosis in Children, coxa plana.
At present for femur head necrosis, mainly taking conservative treatment, late period may take artificial replacement's art, the most not only spends
The highest, and patient is the most painful, even if Post operation effect is the most undesirable.The medicine of existing treatment femur head necrosis
Although having multiple, but there is the shortcomings such as the length course for the treatment of, side effect is big, curative effect is undesirable in varying degrees.
Summary of the invention
It is an object of the invention to provide that a kind of healing time is short, good effect, have no side effect, the treatment of non-relapse after healing
Chinese medicine preparation of femur head necrosis and its preparation method and application, with the problem solving to propose in above-mentioned background technology.
For achieving the above object, the present invention provides following technical scheme:
A kind of Chinese medicine preparation treating femur head necrosis, is made up of according to the raw material of weight portion following: Radix Ranunculi Ternati 15-25 part,
Flos Magnoliae Amoenae 3-10 part, Herba Saginae Japonicae 8-16 part, Ramulus Cinnamomi 1-8 part.
As the further scheme of the present invention: the Chinese medicine preparation of described treatment femur head necrosis, by following former according to weight portion
Material composition: Radix Ranunculi Ternati 18-22 part, Flos Magnoliae Amoenae 5-8 part, Herba Saginae Japonicae 10-14 part, Ramulus Cinnamomi 3-6 part.
As the further scheme of the present invention: the Chinese medicine preparation of described treatment femur head necrosis, by following former according to weight portion
Material composition: Radix Ranunculi Ternati 20 parts, Flos Magnoliae Amoenae 7 parts, Herba Saginae Japonicae 12 parts, Ramulus Cinnamomi 5 parts.
The preparation method of the Chinese medicine preparation of described treatment femur head necrosis, comprises the steps of:
1) Radix Ranunculi Ternati and Herba Saginae Japonicae pulverized, cross 100-200 mesh sieve, after mixing, add the two quality 10-12 times go from
Sub-water, intense fire boils, slow fire boiling 1-1.2h, then soaks 2-3h, prepares mixture A；
2) Flos Magnoliae Amoenae and Ramulus Cinnamomi are pulverized, are crossed 200 mesh sieves, after mixing, add 75% ethanol of the two quality 10-12 times,
Stir process 45-60min at 85-90 DEG C, then carries out supersound process 1.5-2h at 65-70 DEG C, and ultrasonic power is 700W,
Prepare mixture B；
3) being mixed with mixture B by mixture A, supersound process 0.5-0.7h at 65-70 DEG C, ultrasonic power is 700W,
Prepare mixture C；
4) mixture C is warming up to 110-120 DEG C, and stir process 20-30min at such a temperature, discard after centrifugation
Lower sediment, by upper liquid drying Chinese medicine preparation.
The application in preparation treatment femur head necrosis medicine of the described Chinese medicine preparation.
Radix Ranunculi Ternati dissipating phlegm and resolving masses in the present invention, removing toxic substances and promoting subsidence of swelling, treat Drug resistant pulmonary tubeculosis, the most resistance to isoniazid, rifampicin
Patient with streptomycin.Cure mainly pulmonary tuberculosis, malaria, scrofula sucutaneous nodule, furuncle, worm venom, migraine, malaria, toothache.
Tuberculous lymphadenitis, lymphadenitis, pharyngolaryngitis.
Flos Magnoliae Amoenae clearing away heat and promoting diuresis, removing toxic substances and promoting subsidence of swelling, nourishing the lung to arrest cough.Control alcoholic jaundice, congenital deformity of the tongue, carbuncle sore tumefacting virus, xeropulmonary cough, expectorant
Middle band blood.
Herba Saginae Japonicae mass dissipating and swelling eliminating, detoxifying and relieving itching.For leukemia, dermatitis rhus, carbuncle, scrofula, dental caries.
Ramulus Cinnamomi has diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, effect of the flat gas that spins.It is usually used in anemofrigid cold, gastral cavity abdomen
Cold type of pain, cold in blood amenorrhea, arthralgia, phlegm retention, edema, cardiopalmus etc..
Compared with prior art, the invention has the beneficial effects as follows:
The present invention has diuretic dehumidifying, subduing swelling and detoxicating, the dredging collateral that eliminates the phlegm, QI invigorating invigorating the liver and kidney under the synergism of each raw material, is good for
Spleen stomach function regulating, assistant blood circulation and channel invigorating effect, can effectively treat femur head necrosis, healing time is short, cure rate more than 86%,
Effective percentage reaches 100%, has no side effect, non-relapse after healing, wide popularization and application on clinic.
Detailed description of the invention
Below in conjunction with the embodiment of the present invention, the technical scheme in the embodiment of the present invention is clearly and completely described, aobvious
So, described embodiment is only a part of embodiment of the present invention rather than whole embodiments.Based in the present invention
Embodiment, the every other embodiment that those of ordinary skill in the art are obtained under not making creative work premise, all
Belong to the scope of protection of the invention.
Embodiment 1
In the embodiment of the present invention, a kind of Chinese medicine preparation treating femur head necrosis, it is made up of according to the raw material of weight portion following:
Radix Ranunculi Ternati 15 parts, Flos Magnoliae Amoenae 3 parts, Herba Saginae Japonicae 8 parts, Ramulus Cinnamomi 1 part.
Radix Ranunculi Ternati and Herba Saginae Japonicae are pulverized, crossed 100 mesh sieves, after mixing, adds the deionized water of the two quality 10 times, military
Fire is boiled, slow fire boiling 1h, then soaks 2h, prepares mixture A.Flos Magnoliae Amoenae and Ramulus Cinnamomi are pulverized, are crossed 200 mesh sieves,
Add the ethanol that volumetric concentration is 75% of the two quality 10 times, stir process 45min at 85 DEG C after mixing, then exist
Carrying out supersound process 1.5h at 65 DEG C, ultrasonic power is 700W, prepares mixture B.Mixture A is mixed with mixture B
Closing, supersound process 0.5h at 65 DEG C, ultrasonic power is 700W, prepares mixture C.Mixture C is warming up to 110 DEG C,
And stir process 20min at such a temperature, discard lower sediment after centrifugation, by upper liquid drying Chinese medicine preparation.
Embodiment 2
In the embodiment of the present invention, a kind of Chinese medicine preparation treating femur head necrosis, it is made up of according to the raw material of weight portion following:
Radix Ranunculi Ternati 25 parts, Flos Magnoliae Amoenae 10 parts, Herba Saginae Japonicae 16 parts, Ramulus Cinnamomi 8 parts.
Radix Ranunculi Ternati and Herba Saginae Japonicae are pulverized, crossed 200 mesh sieves, after mixing, adds the deionized water of the two quality 12 times, military
Fire is boiled, slow fire boiling 1.2h, then soaks 3h, prepares mixture A.Flos Magnoliae Amoenae and Ramulus Cinnamomi are pulverized, are crossed 200 mesh sieves,
Add 75% ethanol of the two quality 12 times, stir process 60min at 90 DEG C after mixing, then surpass at 70 DEG C
Sonication 2h, ultrasonic power is 700W, prepares mixture B.Mixture A is mixed with mixture B, at 70 DEG C
Supersound process 0.7h, ultrasonic power is 700W, prepares mixture C.Mixture C is warming up to 120 DEG C, and in this temperature
Lower stir process 30min of degree, discards lower sediment, by upper liquid drying Chinese medicine preparation after centrifugation.
Embodiment 3
In the embodiment of the present invention, a kind of Chinese medicine preparation treating femur head necrosis, it is made up of according to the raw material of weight portion following:
Radix Ranunculi Ternati 18 parts, Flos Magnoliae Amoenae 5 parts, Herba Saginae Japonicae 10 parts, Ramulus Cinnamomi 3 parts.
Radix Ranunculi Ternati and Herba Saginae Japonicae are pulverized, crossed 200 mesh sieves, after mixing, adds the deionized water of the two quality 11 times, military
Fire is boiled, slow fire boiling 1.1h, then soaks 2.5h, prepares mixture A.Flos Magnoliae Amoenae and Ramulus Cinnamomi are pulverized, crossed 200 mesh
Sieve, adds 75% ethanol of the two quality 11 times, stir process 5min at 88 DEG C, then carries out at 70 DEG C after mixing
Supersound process 2h, ultrasonic power is 700W, prepares mixture B.Mixture A is mixed with mixture B, at 70 DEG C
Lower supersound process 0.7h, ultrasonic power is 700W, prepares mixture C.Mixture C is warming up to 115 DEG C, and at this
At a temperature of stir process 25min, discard lower sediment after centrifugation, by upper liquid drying Chinese medicine preparation.
Embodiment 4
In the embodiment of the present invention, a kind of Chinese medicine preparation treating femur head necrosis, it is made up of according to the raw material of weight portion following:
Radix Ranunculi Ternati 22 parts, Flos Magnoliae Amoenae 8 parts, Herba Saginae Japonicae 14 parts, Ramulus Cinnamomi 6 parts.
Radix Ranunculi Ternati and Herba Saginae Japonicae are pulverized, crossed 200 mesh sieves, after mixing, adds the deionized water of the two quality 11 times, military
Fire is boiled, slow fire boiling 1.1h, then soaks 2.5h, prepares mixture A.Flos Magnoliae Amoenae and Ramulus Cinnamomi are pulverized, crossed 200 mesh
Sieve, adds 75% ethanol of the two quality 11 times, stir process 5min at 88 DEG C, then carries out at 70 DEG C after mixing
Supersound process 2h, ultrasonic power is 700W, prepares mixture B.Mixture A is mixed with mixture B, at 70 DEG C
Lower supersound process 0.7h, ultrasonic power is 700W, prepares mixture C.Mixture C is warming up to 115 DEG C, and at this
At a temperature of stir process 25min, discard lower sediment after centrifugation, by upper liquid drying Chinese medicine preparation.
Embodiment 5
In the embodiment of the present invention, a kind of Chinese medicine preparation treating femur head necrosis, it is made up of according to the raw material of weight portion following:
Radix Ranunculi Ternati 20 parts, Flos Magnoliae Amoenae 7 parts, Herba Saginae Japonicae 12 parts, Ramulus Cinnamomi 5 parts.
Radix Ranunculi Ternati and Herba Saginae Japonicae are pulverized, crossed 200 mesh sieves, after mixing, adds the deionized water of the two quality 11 times, military
Fire is boiled, slow fire boiling 1.1h, then soaks 2.5h, prepares mixture A.Flos Magnoliae Amoenae and Ramulus Cinnamomi are pulverized, crossed 200 mesh
Sieve, adds 75% ethanol of the two quality 11 times, stir process 5min at 88 DEG C, then carries out at 70 DEG C after mixing
Supersound process 2h, ultrasonic power is 700W, prepares mixture B.Mixture A is mixed with mixture B, at 70 DEG C
Lower supersound process 0.7h, ultrasonic power is 700W, prepares mixture C.Mixture C is warming up to 115 DEG C, and at this
At a temperature of stir process 25min, discard lower sediment after centrifugation, by upper liquid drying Chinese medicine preparation.
Comparative example 1
In addition to not containing Flos Magnoliae Amoenae, its formula and preparation process are consistent with embodiment 5.
Comparative example 2
Containing only Flos Magnoliae Amoenae, its preparation process is consistent with embodiment 5.
In order to prove the therapeutic effect of Chinese medicine preparation of the present invention, carry out following experiments.
One, toxicity test
The Chinese medicine preparation of the present invention is a kind of Chinese medicine preparation that can treat femur head necrosis, the existing Chinese medicine prepared with embodiment 5
As a example by preparation, carry out studies on acute toxicity.
1, experiment material
1.1 medicines: the Chinese medicine preparation that embodiment 5 is made.
1.2 animals: mice, Kunming kind, body weight 18-22 gram, male and female all use, real purchased from Shandong anti-Pharmaceutical Group Lu Yuan branch company
Test animal center.
2, method and result
Take body weight 18-22 gram kunming mice 10, male and female half and half, gavage this product 33mg/10 gram, normally raise, see
Examine seven days.
Result: animal is taken food, drinking-water, fur, extremity are movable the most without exception with behavior etc., and body weight increases, and dissects naked eyes and sees
Wipe, main organs no abnormality seen.
3, brief summary and discussion
Gavage 33mg/10 gram of the present invention, seeing to wipe has any toxic reaction less than animal to this, due to by preparation and perfusion
Approach consumption is limited, and gavage cannot obtain the mice median lethal dose(LD 50) to bone growth promoting ball, can only substantially calculate that gavage of mice is raw
The maximum tolerated dose (MTO) of bone ball is more than 33mg/10g.This dose is calculated by kg body weight, is equivalent to people's dose
More than 100 times, the medicine of embodiment 5 is safe without toxic side effect in the case of oral.
It is the most without exception that medicine obtained in other scope of the invention carries out toxicity test.
Two, zoopery
1, case source
At certain province's 350 Patients with Aseptic Necrosis of Femoral of various big hospital random choose as drug use volunteer, wherein, male suffers from
Person 170, female patient 180, patient age is between 35-65 year, and patient's mild or moderate, moderate, the severe state of an illness are equal
Having, the severe state of an illness accounts for 20-30%, state of an illness judgment basis country relevant regulations.
2, experimental technique
According to sex, age, the state of an illness, Patients with Aseptic Necrosis of Femoral being equally divided into 7 groups, often organizes 50 examples, wherein treatment group is altogether
Five groups, it is respectively treatment 1 group, treats 2 groups, treat 3 groups, treat 4 groups, treat 5 groups, use embodiment 1-5 respectively
Medicine, matched group totally 2 groups, it is respectively comparison 1 group, compares 2 groups, use comparative example 1-2 medicine respectively, respectively organize patient
Age, sex, the course of disease and severity extent aspect comparing difference without significance (P > 0.05), there is comparability.
3, application method
The medicine of embodiment 1-5 prepared according to the inventive method and comparative example 1-2 is granted patient respectively, and application method is
1g every time, 2 times on the one.
4, criterion
Curing: after using one month, the state of an illness is fully recovered.
Effective: after using one month, the state of an illness is substantially alleviated, the transference cure such as pain, numbness, swelling or substantially disappear；
Effective: after using one month, the state of an illness has been alleviated, the symptom such as pain, numbness, swelling substantially alleviates；
Invalid: after using one month, the state of an illness is without alleviating or aggravation.
5, experimental result.As shown in table 1.
Table 1 Patients with Aseptic Necrosis of Femoral treatment situation
| Group | Total number of cases | Cure | Effective | Effectively | Invalid | Total effective rate % |
| Treat 1 group | 50 | 43 | 2 | 5 | 0 | 100 |
| Treat 2 groups | 50 | 44 | 3 | 3 | 0 | 100 |
| Treat 3 groups | 50 | 47 | 1 | 2 | 0 | 100 |
| Treat 4 groups | 50 | 48 | 1 | 1 | 0 | 100 |
| Treat 5 groups | 50 | 50 | 0 | 0 | 0 | 100 |
| Compare 1 group | 50 | 4 | 8 | 15 | 23 | 54 |
| Compare 2 groups | 50 | 0 | 4 | 10 | 36 | 28 |
6, experiment conclusion
From above-mentioned experimental result it can be seen that femur head necrosis is had well under the common effect of each raw material by medicine of the present invention
Therapeutic effect, and the cured substance time of the present invention is short, cure rate is high, and more than 86%, effective percentage is high, is 100%, nothing
Toxic and side effects, non-relapse after healing.
Model case:
1. Pan, female, 43 years old, once at certain hospital punching decompression treatment, disease relapse after half a year, on inspection, unilateral femur
Downright bad 2 phases.Take embodiment 5 medicine, treat one and a half months, move such as normal person after 2 months, there is no pain symptom.
2. Lee, man, 52 years old, femur head necrosis 2 phase, especially sensation marrow and knee pain, had an intense pain upstairs, go
Shenyang hospital diagnosis, right lateral thigh head necrosis, take embodiment 4 medicine 3 days, pain relief is obvious on foot, can more than
Step.Continue to take healing in 20 days, after do not recur.
It is obvious to a person skilled in the art that the invention is not restricted to the details of above-mentioned one exemplary embodiment, and do not carrying on the back
In the case of the spirit or essential attributes of the present invention, it is possible to realize the present invention in other specific forms.Therefore, no matter from
From the point of view of which point, all should regard embodiment as exemplary, and be nonrestrictive, the scope of the present invention is by appended power
Profit requires rather than described above limits, it is intended that all by fall in the implication of equivalency and scope of claim
Change is included in the present invention.
Although moreover, it will be appreciated that this specification is been described by according to embodiment, but the most each embodiment only comprises
One independent technical scheme, this narrating mode of description is only the most for clarity sake, and those skilled in the art should be by
Description is as an entirety, and the technical scheme in each embodiment can also be through appropriately combined, and forming those skilled in the art can
With other embodiments understood.
Claims (5)
1. the Chinese medicine preparation treating femur head necrosis, it is characterised in that be made up of according to the raw material of weight portion following: cat
Pawl grass 15-25 part, Flos Magnoliae Amoenae 3-10 part, Herba Saginae Japonicae 8-16 part, Ramulus Cinnamomi 1-8 part.
The Chinese medicine preparation for the treatment of femur head necrosis the most according to claim 1, it is characterised in that by following according to weight
The raw material composition of part: Radix Ranunculi Ternati 18-22 part, Flos Magnoliae Amoenae 5-8 part, Herba Saginae Japonicae 10-14 part, Ramulus Cinnamomi 3-6 part.
The Chinese medicine preparation for the treatment of femur head necrosis the most according to claim 2, it is characterised in that by following according to weight
The raw material composition of part: Radix Ranunculi Ternati 20 parts, Flos Magnoliae Amoenae 7 parts, Herba Saginae Japonicae 12 parts, Ramulus Cinnamomi 5 parts.
4. a preparation method for the Chinese medicine preparation of the treatment femur head necrosis as described in claim 1-3 is arbitrary, its feature exists
In, comprise the steps of:
1) Radix Ranunculi Ternati and Herba Saginae Japonicae pulverized, cross 100-200 mesh sieve, after mixing, add the two quality 10-12 times go from
Sub-water, intense fire boils, slow fire boiling 1-1.2h, then soaks 2-3h, prepares mixture A；
2) Flos Magnoliae Amoenae and Ramulus Cinnamomi are pulverized, are crossed 200 mesh sieves, after mixing, add 75% ethanol of the two quality 10-12 times,
Stir process 45-60min at 85-90 DEG C, then carries out supersound process 1.5-2h at 65-70 DEG C, and ultrasonic power is 700W,
Prepare mixture B；
3) being mixed with mixture B by mixture A, supersound process 0.5-0.7h at 65-70 DEG C, ultrasonic power is 700W,
Prepare mixture C；
4) mixture C is warming up to 110-120 DEG C, and stir process 20-30min at such a temperature, discard after centrifugation
Lower sediment, by upper liquid drying Chinese medicine preparation.
5. the application in preparation treatment femur head necrosis medicine of the Chinese medicine preparation as described in claim 1-3 is arbitrary.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107279580A (en) * | 2017-07-29 | 2017-10-24 | 丁文海 | A kind of feed addictive for improving immunity and its preparation method and application |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102178895A (en) * | 2011-04-27 | 2011-09-14 | 胡建忠 | Chinese medicine composition for treating orthopedic disorders and preparation method thereof |
| CN104740413A (en) * | 2015-04-20 | 2015-07-01 | 马扩助 | Traditional Chinese medicine for treating phlegm-stasis blocking collateral type femoral head necrosis and preparation method of traditional Chinese medicine |
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2016
- 2016-05-20 CN CN201610356548.9A patent/CN105770034A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102178895A (en) * | 2011-04-27 | 2011-09-14 | 胡建忠 | Chinese medicine composition for treating orthopedic disorders and preparation method thereof |
| CN104740413A (en) * | 2015-04-20 | 2015-07-01 | 马扩助 | Traditional Chinese medicine for treating phlegm-stasis blocking collateral type femoral head necrosis and preparation method of traditional Chinese medicine |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107279580A (en) * | 2017-07-29 | 2017-10-24 | 丁文海 | A kind of feed addictive for improving immunity and its preparation method and application |
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