CN105726174A - Intravascular stent and preparation method and application thereof - Google Patents
Intravascular stent and preparation method and application thereof Download PDFInfo
- Publication number
- CN105726174A CN105726174A CN201610268333.1A CN201610268333A CN105726174A CN 105726174 A CN105726174 A CN 105726174A CN 201610268333 A CN201610268333 A CN 201610268333A CN 105726174 A CN105726174 A CN 105726174A
- Authority
- CN
- China
- Prior art keywords
- intravascular stent
- section
- repeated monomer
- repeated
- monomer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 7
- 210000003111 iliac vein Anatomy 0.000 claims abstract description 28
- 239000000178 monomer Substances 0.000 claims description 77
- 238000000034 method Methods 0.000 claims description 11
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 8
- 239000000463 material Substances 0.000 claims description 8
- 229910052751 metal Inorganic materials 0.000 claims description 8
- 239000002184 metal Substances 0.000 claims description 8
- 229910045601 alloy Inorganic materials 0.000 claims description 6
- 239000000956 alloy Substances 0.000 claims description 6
- 229910000831 Steel Inorganic materials 0.000 claims description 5
- 229920002988 biodegradable polymer Polymers 0.000 claims description 5
- 239000004621 biodegradable polymer Substances 0.000 claims description 5
- 239000010959 steel Substances 0.000 claims description 5
- 229910000861 Mg alloy Inorganic materials 0.000 claims description 4
- 238000013461 design Methods 0.000 claims description 4
- 150000002739 metals Chemical class 0.000 claims description 4
- 229910001362 Ta alloys Inorganic materials 0.000 claims description 3
- 229910001069 Ti alloy Inorganic materials 0.000 claims description 3
- 229910052742 iron Inorganic materials 0.000 claims description 3
- 238000005554 pickling Methods 0.000 claims description 2
- 210000003462 vein Anatomy 0.000 abstract description 7
- 230000015572 biosynthetic process Effects 0.000 abstract description 4
- 206010070995 Vascular compression Diseases 0.000 description 7
- 208000011580 syndromic disease Diseases 0.000 description 6
- 208000007536 Thrombosis Diseases 0.000 description 5
- 210000000988 bone and bone Anatomy 0.000 description 4
- 238000001514 detection method Methods 0.000 description 4
- 238000010586 diagram Methods 0.000 description 4
- 210000003141 lower extremity Anatomy 0.000 description 4
- 206010047249 Venous thrombosis Diseases 0.000 description 3
- 208000027418 Wounds and injury Diseases 0.000 description 3
- 230000017531 blood circulation Effects 0.000 description 3
- 210000004204 blood vessel Anatomy 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 206010051055 Deep vein thrombosis Diseases 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 238000010276 construction Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000010147 laser engraving Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 229910001000 nickel titanium Inorganic materials 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 230000000638 stimulation Effects 0.000 description 2
- 238000007631 vascular surgery Methods 0.000 description 2
- 229910018131 Al-Mn Inorganic materials 0.000 description 1
- 229910018461 Al—Mn Inorganic materials 0.000 description 1
- 229910000640 Fe alloy Inorganic materials 0.000 description 1
- 229910001021 Ferroalloy Inorganic materials 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 206010034272 Pelvic venous thrombosis Diseases 0.000 description 1
- 229920000954 Polyglycolide Polymers 0.000 description 1
- 208000006193 Pulmonary infarction Diseases 0.000 description 1
- 206010046996 Varicose vein Diseases 0.000 description 1
- HZEWFHLRYVTOIW-UHFFFAOYSA-N [Ti].[Ni] Chemical compound [Ti].[Ni] HZEWFHLRYVTOIW-UHFFFAOYSA-N 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 210000003191 femoral vein Anatomy 0.000 description 1
- 210000003090 iliac artery Anatomy 0.000 description 1
- KHYBPSFKEHXSLX-UHFFFAOYSA-N iminotitanium Chemical compound [Ti]=N KHYBPSFKEHXSLX-UHFFFAOYSA-N 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 210000004731 jugular vein Anatomy 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 229920000747 poly(lactic acid) Polymers 0.000 description 1
- 239000004633 polyglycolic acid Substances 0.000 description 1
- 239000004626 polylactic acid Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000007575 pulmonary infarction Effects 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000008320 venous blood flow Effects 0.000 description 1
- 208000037997 venous disease Diseases 0.000 description 1
- 238000003466 welding Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
- A61F2/954—Instruments specially adapted for placement or removal of stents or stent-grafts for placing stents or stent-grafts in a bifurcation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2002/823—Stents, different from stent-grafts, adapted to cover an aneurysm
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2002/825—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents having longitudinal struts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2240/00—Manufacturing or designing of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2240/001—Designing or manufacturing processes
- A61F2240/002—Designing or making customized prostheses
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
Abstract
The invention relates to an intravascular stent and a preparation method and application thereof. The intravascular stent comprises a positioning section and a supporting section, the positioning section comprises a plurality of first repeat single parts, the supporting section comprises at least two supporting units and at least one connection unit, each supporting unit comprises a plurality of second repeat single parts, the first repeat single parts are not as many as the second repeat single parts, and a plane formed by the front ends of the first repeat single parts are perpendicular to the axis of the intravascular stent. The intravascular stent is especially applicable to iliac veins, effective in iliac vein supporting, less in harms to vein walls and capable of effectively avoiding formation of secondary thrombi in the implanted intravascular stent. In addition, the intravascular stent is capable of well positioning in the iliac veins, release accuracy is improved, and convenience in operation is achieved. Furthermore, the intravascular stent is simple in structure, convenient to produce and low in cost, thereby having important practical significances and promising clinical application prospect.
Description
Technical field
The invention belongs to medical instruments field, be specifically related to a kind of intravascular stent, its preparation method and application.
Background technology
Venous disease is most commonly seen in vascular surgery disease, and especially deep vein thrombosis of lower extremity and lower limb great saphenous varicose vein are more common.And having in the reason that both diseases are formed is caused by iliac vein compression greatly.Detection of iliac vein compression syndrome (iliacveincompressionsyndrome, IVCS) mean that iliac vein is oppressed by iliac artery, cause intracavity adhesion, narrow or inaccessible, thus there is the syndrome of range of clinical symptom, also known as May Thurner, Cockett syndrome.Detection of iliac vein compression syndrome incidence rate is 20%～34%.
Solving compression of vein to perform the operation in treatment, owing to needs enter abdomen operation, wound is relatively big, and patient is difficult to accept always always, therefore less in the operation number of cases of China's report.Cause that a lot of patient's lower extremity swelling and distension cannot solve, have some patients, because the blood stasis of blood is stagnant, phlebothrombosis occurs.Development from eighties of last century the nineties interventional technique, domestic begin through balloon expandable, the method of stent endoprosthesis solves iliac vein compression, through the clinical treatment of nearly 20 years, the method of interventional therapy is accepted by vascular surgery circle, simultaneously because wound is little, patient also can accept, and now domestic have a lot of hospital to carry out this work.Also have a lot of doctors that this technology is used for the patient of iliac vein thrombosis sequela simultaneously.Along with being significantly increased of clinical disease number of cases, and the arterial bracket that the clinical bore of use always is bigger at present treats the patient of detection of iliac vein compression syndrome, thus occurring in that an important problem, namely in support, the probability of secondary thrombus is higher, this is little with arterial bracket mesh, and the structure of iliac vein causes that arterial bracket must stretch into postcava 1-1.5 centimetre, and its support force does not cause designed by vein.
At present, the research report display of lot of domestic and foreign, less with the support that detection of iliac vein compression syndrome designs for indication.Domestic have can be taken off self-inflated bone vein support (utility model: 201520126120.6) effectively prevention deep vein thrombosis of lower extremity and come off the pulmonary infarction caused, after completing therapeutic purposes, can take out through jugular vein or femoral vein approach and avoid support Preserving time to produce complication.The latticed webmaster being coiled into for treating the narrow support of iliac vein (utility model: 201320053442.3) to be woven by nickel-titanium metal silk, webmaster front tube actinal surface is inclined-plane, the angle of inclined-plane and webmaster section is 40 degree, webmaster has the labelling circle of ellipse, it is achieved accurate positioning.But these bone vein supports yet suffer from some problems: be not all suitable for recovering bone venous blood flow state and increasing blood flow, and be easily caused the formation of thrombosis, thus be necessary to carry out research and development and the applied research of novel bone vein support.
Summary of the invention
The technical problem to be solved is to overcome the deficiencies in the prior art, intravascular stent, its preparation method and application that a kind of structure is different are provided, this intravascular stent has and is not easily formed thrombosis, histocompatibility is good, the support force of vein suitably and is not affected blood flow, simple in construction, easy to operate, accurate positioning, it is possible to meet the needs to iliac vein treatment in clinic.
For solving above technical problem, the present invention adopts the following technical scheme that
It is an object of the present invention to provide a kind of intravascular stent, it can change to the expansion state of the second cross-sectional diameter having had extended from the compressive state with the first cross-sectional diameter,
Described intravascular stent includes the location section and the support section that are connected on the axis direction of described intravascular stent,
Described location section includes circumferentially distributed multiple first repeated monomers along described intravascular stent,
Described supports at least two support unit and at least one the connection unit that section includes adjoining one another on the axis direction of described intravascular stent, and described support unit includes circumferentially distributed multiple second repeated monomers along described intravascular stent,
The number of the first described repeated monomer is different from the number of the second described repeated monomer, the axis perpendicular of the plane that the leading section of multiple the first described repeated monomers is formed and described intravascular stent.
According to an embodiment of the invention, the number of the first described repeated monomer is less than the number of the second described repeated monomer.
Preferably, the number of the second described repeated monomer is 2 ~ 4 times of the number of the first described repeated monomer, and the number of the first described repeated monomer is 4 to 10.
Further, the described leading section supporting section is connected to the first developing cell.
According to a preferred aspect of the present invention, the leading section of described the second repeated monomer supporting section is connected to the first developing cell, and the number of the first developing cell can equal can not also wait with the number of the first described repeated monomer.
In the present invention, the first repeated monomer can be connected with the second repeated monomer, it is also possible to is connected with being connected unit.
According to an embodiment of the invention, the described bearing of trend of location section is 0 ° ~ 60 ° with the angle of the axis direction of described intravascular stent.
Preferably, when the described bearing of trend of location section is 0 ° with the angle of the axis direction of described intravascular stent, described intravascular stent is substantially in cylinder；When the described bearing of trend of location section has angle with the axis direction of described intravascular stent, described location section extends away from the direction of the axis of described intravascular stent towards leading section gradually from the one end being connected with described support section.
According to a preferred aspect of the present invention, the leading section of the first described repeated monomer is fillet, and the circular arc internal diameter radius of fillet is be more than or equal to 0.1mm.
According to a preferred aspect of the present invention, the length of the first described repeated monomer is 5 ~ 15mm, it is preferred to 10 ~ 15mm；The described length supporting section is 40 ~ 140mm, it is preferred to 60 ~ 120mm；The thickness of described intravascular stent is 0.1 ~ 0.3mm.
According to an embodiment of the invention, the length of the second described repeated monomer is 1 ~ 7mm, it is preferred to 2 ~ 5mm.
Preferably, the described rearward end supporting section is connected to multiple second developing cell.It is further preferable that the number of the second described developing cell is 3 to 10.
According to a specific embodiment of the present invention, the described unit that connects includes the circumferentially distributed multiple connectors along described intravascular stent, the number of the no more than second described repeated monomer of number of described connector.
Preferably, the width of described connector is 0.1 ~ 0.3mm.
In the present invention, the width of described connector is equal with the width of the first described repeated monomer.
In the present invention, the width of the second described repeated monomer can adopt regular width, for instance 0.1 ~ 0.3mm.
In the present invention, the material of described intravascular stent is one or more in rustless steel, memorial alloy, titanium alloy, tantalum alloy, cochrome, biodegradable metals, biodegradable polymer, magnesium alloy, pure iron.
The preparation method that it is a further object to provide a kind of above-mentioned intravascular stent, carries out cut by material according to the path on support Design drawing, then processes obtain described intravascular stent through pickling, electrochemical process.
Certainly, the intravascular stent of the present invention can also adopt additive method to be prepared, for instance, weave or welding.
3rd purpose of the present invention is to provide a kind of stent delivery system, and it includes above-mentioned intravascular stent.
4th purpose of the present invention is to provide a kind of above-mentioned intravascular stent purposes in bifurcated vessels.
Preferably, the present invention provides a kind of above-mentioned intravascular stent purposes in iliac vein.
The present invention is defined as the front of intravascular stent positioning side, section place, is defined as the rear of intravascular stent supporting side, section place.
In the present invention, the angle of definition is the angle less than 90 ° formed between straight line and plane or straight line and straight line.
The total length of the intravascular stent in the present invention refers to the leading section the longest vertical dimension to the second developing cell of the first repeated monomer.The length of the first repeated monomer and the second repeated monomer refers to the leading section vertical dimension to rearward end of each repeated monomer.Support the length of section and refer to that the first developing cell is to the vertical dimension between the second developing cell.
Due to the enforcement of technique scheme, the present invention compared with prior art has the advantage that
The intravascular stent of the present invention is particularly well-suited to iliac vein, the support effect of iliac vein is good and the injury of wall of vein is little, it is possible to be prevented effectively from intravascular stent and implant the formation of secondary thrombus in after-poppet, in addition, the intravascular stent of the present invention can be good at positioning in iliac vein, improves the accuracy of release, easy and simple to handle, the simple in construction of the intravascular stent of the present invention, convenient for production, cost is low, thus having important practical significance and good potential applicability in clinical practice.
Accompanying drawing explanation
Fig. 1 is the schematic diagram (bearing of trend of location section is consistent with the axis direction of intravascular stent) that the intravascular stent of embodiment 1 is implanted in iliac vein；
Fig. 2 is the structural representation that the intravascular stent of embodiment 1 is launched into plane；
Fig. 3 is the intravascular stent axonometric chart (bearing of trend of location section is consistent with the axis direction of intravascular stent) at expansion state of embodiment 1；
Fig. 4 is the intravascular stent axonometric chart (location section is horn mouth shape) at expansion state of embodiment 1；
Fig. 5 is the enlarged drawing of the first connector；
Fig. 6 is the enlarged drawing of the first repeated monomer；
Fig. 7 is the structural representation that the intravascular stent of embodiment 2 is launched into plane；
Fig. 8 is the intravascular stent axonometric chart (bearing of trend of location section is consistent with the axis direction of intravascular stent) at expansion state of embodiment 2；
Fig. 9 is the intravascular stent axonometric chart (location section is horn mouth shape) at expansion state of embodiment 2；
Figure 10 is the schematic diagram (location section is horn mouth shape) that the intravascular stent of embodiment 1 is implanted in iliac vein；
Figure 11 is the schematic diagram (bearing of trend of location section is consistent with the axis direction of intravascular stent) that the intravascular stent of embodiment 2 is implanted in iliac vein；
Figure 12 is the schematic diagram (location section is horn mouth shape) that the intravascular stent of embodiment 2 is implanted in iliac vein；
Wherein: 1, location section；11, the first repeated monomer；2, central support section；21, support unit；211, the second repeated monomer；22, unit is connected；221, connector；4, the first developing cell；5, the second developing cell；β is the angle of the plane that formed of the leading section of the first repeated monomer and the axis of intravascular stent；W1 is the width of connector；W3 is the width of the first repeated monomer；W4 is the width of the second repeated monomer；L1 is the length of the first repeated monomer；L2 is the length supporting section；L4 is the length of the second repeated monomer；L6 is the intravascular stent total length when expansion state.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention will be further described in detail, but the present invention is not limited to following example.
The intravascular stent of the present invention is primarily adapted for use in bifurcated vessels, is particularly well-suited in iliac vein (such as Fig. 1).In the process that intravascular stent is implanted iliac vein, intravascular stent is arranged in the carrier of stent delivery system, now, intravascular stent is in compressive state, after intravascular stent is delivered to correct position by carrier, release intravascular stent, intravascular stent expands outwardly to expansion state, thus iliac vein is played a supporting role, intravascular stent has the first cross section when compressive state, there is the second cross section when expansion state state, and, the diameter of the first cross section is less than the diameter of the second cross section.In the present invention, the first cross section and the second cross section are the cross section supporting section 2, and the axis perpendicular of this cross section and intravascular stent.In the present embodiment, the external diameter of the second cross section is 10 ~ 20mm, it is preferred to 12 ~ 16mm.
The material of intravascular stent is one or more in rustless steel, memorial alloy, titanium alloy, tantalum alloy, cochrome, biodegradable metals, biodegradable polymer, magnesium alloy, pure iron.Rustless steel can adopt SUS-316L rustless steel etc..Memorial alloy can adopt Ni-Ti alloy, Cu-Al-Mn alloy etc..Cochrome can adopt CoCr-L605 cochrome etc..Biodegradable metals is a kind of metal that can decompose in human body, for instance pure magnesium, magnesium alloy, pure iron and ferroalloy etc..Biodegradable polymer can be polylactic acid, polyglycolic acid, poly-(lactic acid-6-caprolactone), gathers Biodegradable polymerics such as (glycolic-6-caprolactones).In addition, it is possible in vivo in degradable metal, coat a kind of biodegradable polymer material and be used as the material of intravascular stent.
The intravascular stent of the present invention can utilize laser engraving one-shot forming.The production process of laser engraving: first, utilizes CAM to create cutting path based on support Design drawing；Secondly, metal or macromolecular material are carried out cut；Finally, improve surface smoothness through overpickling and electrochemical process, make each edge shape mellow and full.
As shown in Figures 2 and 3, intravascular stent includes connecting from front to back on the axis direction of intravascular stent location section 1 and support section 2.
Location section 1 includes circumferentially distributed multiple first repeated monomers 11 along intravascular stent.
Support at least two support unit 21 and at least one connection unit 22 that section 2 includes adjoining one another on the axis direction of intravascular stent, support unit 21 includes circumferentially distributed multiple second repeated monomers 211 along intravascular stent, connects unit 22 and includes the circumferentially distributed multiple connectors 221 along intravascular stent.The number of no more than second repeated monomer 211 of number of connector 221, it is preferable that the number of the second repeated monomer 211 in each support unit 21 is 2 ~ 3 times of connector 221 number in each connection unit 22.
The first repeated monomer 11 and the structure of the second repeated monomer 211 in the present invention can be able to be formed the arbitrary shape in hole, for instance V-type, grid type, rhombus etc..The connector 221 distribution mode on whole intravascular stent can be arbitrary, for instance form of straight lines, V-type, W type, S type, N-type etc..
In the present invention, the leading section supporting section 2 is connected to the first developing cell 4, and in the present embodiment, the leading section of the second repeated monomer 211 supporting section 2 is connected to the first developing cell 4, the setting of the first developing cell 4 makes intravascular stent can be good at realizing location, facilitates doctor to find point of release accurately.
In the present embodiment, the rearward end of the first repeated monomer 11 is connected with the leading section of the second repeated monomer 211.
In the present invention, the number of the first repeated monomer 11 is 4 to 10, and the number of the first developing cell 4 is equal or different with the number of the first repeated monomer 11.
In the present invention, the rearward end supporting section 2 is connected to multiple second developing cell 5, and the number of the second developing cell 5 is 3 to 10, and, the number of the second developing cell 5 is equal with the number of the first developing cell 4.In the present embodiment, the second developing cell 5 can be connected with support unit 21, or is connected with being connected unit 22, and the second developing cell 5 is uniformly distributed along the circumference of intravascular stent.
In the present invention, the number of the first repeated monomer 11 is different from the number of the second repeated monomer 211.Preferably, the number of the first repeated monomer 11 is less than the number of the second repeated monomer 211, in the present embodiment, the number of the second repeated monomer 211 is 2 ~ 4 times of the number of the first repeated monomer 11, thus ensureing that the aperture that the first repeated monomer 11 is formed is bigger, after as shown in Figure 1 intravascular stent being implanted iliac vein, when location section 1 extends postcava, it is possible to avoid because the aperture of intravascular stent is less of causing the formation of thrombosis and avoiding location section 1 that the blood flow of opposite iliac vein is impacted.
In the present embodiment, the bearing of trend of location section 1 is 0 ° ~ 45 ° with the angle of the axis direction of intravascular stent.As it is shown on figure 3, the bearing of trend of location section 1 is consistent with the axis direction of intravascular stent, namely angle is 0 °, and now, intravascular stent is substantially cylinder type when expansion state.As shown in Figure 4, angle is there is in the bearing of trend of location section 1 with the axis direction of intravascular stent, and, location section 1 extends away from the direction of the axis of intravascular stent towards leading section gradually from the one end being connected with support section 2, and namely location section 1 is in the horn mouth shape expanded outwardly gradually from back to front.
In the present embodiment, the width W1(of connector 221 is as shown in Figure 5) it is 0.1 ~ 0.3mm.The width W1 of the connector 221 and width W3(of the first repeated monomer 11 is as shown in Figure 6) equal.The width W4(of the second repeated monomer 211 is as shown in Figure 5) regular width can be adopted, for instance 0.1 ~ 0.3mm.
In the present embodiment, the thickness 0.1 ~ 0.3mm(of intravascular stent is not shown), the thickness of intravascular stent refers to the external diameter of the cross section of intravascular stent and the difference of internal diameter.
In the present embodiment, the leading section of the first repeated monomer 11 is fillet, and the circular arc internal diameter radius of fillet is not shown more than 0.1mm(), thus decreasing the intravascular stent stimulation to blood vessel.
In the present embodiment, the length L1 of the first repeated monomer 11 is 5 ~ 15mm, it is preferred to 10 ~ 15mm, and the length of the first repeated monomer 11 is long, can cause that the leading section of the first repeated monomer 11 touches the blood vessel wall on opposite and causes the adverse effects such as the stimulation to blood vessel；The length of the first repeated monomer 11 is too short, then can affect intravascular stent location in iliac vein so that intravascular stent cannot stably be implanted in desired location.
The length L2 supporting section 2 is 40 ~ 140mm, it is preferred to 60 ~ 120mm, the length L4 of the second repeated monomer 211 is 1 ~ 7mm, it is preferred to 2 ~ 5mm.That is, supporting section 2 and generally comprise 16 support units 21, certainly, the number of support unit 21 can also be adjusted according to actual needs.
The intravascular stent of the present invention total length L 6 when expansion state is 50 ~ 120mm, it is preferred to 60 ~ 100mm.
Embodiment 1 is identical with the foregoing of embodiment 2, difference only with: in embodiment 1, the axis perpendicular of the plane that the leading section of multiple first repeated monomers 11 is formed and intravascular stent, as shown in Figures 2 and 3.In embodiment 2, the axes intersect of the plane that the leading section of multiple first repeated monomers 11 is formed and intravascular stent, and the angle β of the axis of the plane that the leading section of multiple first repeated monomers 11 is formed and intravascular stent is 45 ° ~ 89 °, as shown in Figs. 7-9, wherein, in Fig. 7 to 9, the angle β of the axis of the plane that the leading section of multiple first repeated monomers 11 is formed and intravascular stent is 70 °, in embodiment 2, the length of the first repeated monomer 11 gradually changes, but, its length range should within the length range of the first repeated monomer 11 of above-mentioned restriction.
Above the present invention is described in detail; its object is to allow the personage being familiar with this art will appreciate that present disclosure and to be carried out; can not limit the scope of the invention with this; and the invention is not restricted to the embodiments described; the equivalence that all spirit according to the present invention are made changes or modifies, and all should be encompassed within protection scope of the present invention。
Claims (13)
1. an intravascular stent, it can change to the expansion state of the second cross-sectional diameter having had extended from the compressive state with the first cross-sectional diameter, it is characterised in that:
Described intravascular stent includes the location section (1) and support section (2) that are connected on the axis direction of described intravascular stent,
Described location section (1) includes circumferentially distributed multiple first repeated monomers (11) along described intravascular stent,
Described support section (2) includes at least two support unit (21) and at least one connection unit (22) that adjoin one another on the axis direction of described intravascular stent, described support unit (21) includes circumferentially distributed multiple second repeated monomers (211) along described intravascular stent
The number of described the first repeated monomer (11) is different from the number of described the second repeated monomer (211), the axis perpendicular of the plane that the leading section of multiple described the first repeated monomers (11) is formed and described intravascular stent.
2. intravascular stent according to claim 1, it is characterised in that: the number of described the first repeated monomer (11) is less than the number of described the second repeated monomer (211).
3. intravascular stent according to claim 2, it is characterised in that: the number of described the second repeated monomer (211) is 2 ~ 4 times of the number of described the first repeated monomer (11), and the number of described the first repeated monomer (11) is 4 to 10.
4. intravascular stent according to claim 1, it is characterised in that: the leading section of described support section (2) is connected to the first developing cell (4).
5. intravascular stent according to claim 1, it is characterised in that: the angle of the bearing of trend of described location section (1) and the axis direction of described intravascular stent is 0 ° ~ 60 °.
6. intravascular stent according to claim 1, it is characterised in that: the leading section of described the first repeated monomer (11) is fillet, and the circular arc internal diameter radius of fillet is be more than or equal to 0.1mm.
7. intravascular stent according to claim 1, it is characterised in that: the length of described the first repeated monomer (11) is 5 ~ 15mm, and the length of described support section (2) is 40 ~ 140mm, and the thickness of described intravascular stent is 0.1 ~ 0.3mm.
8. intravascular stent according to claim 1, it is characterised in that: the rearward end of described support section (2) is connected to multiple second developing cell (5), and the number of described the second developing cell (5) is 3 to 10.
9. intravascular stent according to claim 1, it is characterized in that: described connection unit (22) includes the circumferentially distributed multiple connectors (221) along described intravascular stent, the number of no more than described second repeated monomer (211) of number of described connector (221), the width of described connector (221) is 0.1 ~ 0.3mm.
10. intravascular stent according to claim 1, it is characterised in that: the material of described intravascular stent is one or more in rustless steel, memorial alloy, titanium alloy, tantalum alloy, cochrome, biodegradable metals, biodegradable polymer, magnesium alloy, pure iron.
11. the preparation method of the intravascular stent as according to any one of claim 1 to 10, it is characterised in that: material is carried out cut according to the path on support Design drawing, then processes obtain described intravascular stent through pickling, electrochemical process.
12. the purposes that the intravascular stent as according to any one of claim 1 to 10 is in bifurcated vessels.
13. the purposes that the intravascular stent as according to any one of claim 1 to 10 is in iliac vein.
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610268333.1A CN105726174B (en) | 2016-04-27 | 2016-04-27 | A kind of intravascular stent, preparation method and application |
| PCT/CN2016/089590 WO2017185529A1 (en) | 2016-04-27 | 2016-07-11 | Vascular stent, preparation method therefor, and application thereof |
| US15/737,365 US10695201B2 (en) | 2016-04-27 | 2016-07-11 | Intravascular stent, preparation method and use thereof |
| EP16900039.5A EP3449878A4 (en) | 2016-04-27 | 2016-07-11 | VESSELED, MANUFACTURING PROCESS FOR IT AND APPLICATION THEREOF |
| US16/878,320 US11471309B2 (en) | 2016-04-27 | 2020-05-19 | Intravascular stent, preparation method and use thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610268333.1A CN105726174B (en) | 2016-04-27 | 2016-04-27 | A kind of intravascular stent, preparation method and application |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105726174A true CN105726174A (en) | 2016-07-06 |
| CN105726174B CN105726174B (en) | 2018-06-29 |
Family
ID=56285707
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610268333.1A Active CN105726174B (en) | 2016-04-27 | 2016-04-27 | A kind of intravascular stent, preparation method and application |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105726174B (en) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106176003A (en) * | 2016-07-06 | 2016-12-07 | 苏州天鸿盛捷医疗器械有限公司 | A kind of intravascular stent, its preparation method and application |
| CN106963451A (en) * | 2017-03-29 | 2017-07-21 | 上海心玮医疗科技有限公司 | One kind takes bolt device |
| WO2017185529A1 (en) * | 2016-04-27 | 2017-11-02 | 苏州天鸿盛捷医疗器械有限公司 | Vascular stent, preparation method therefor, and application thereof |
| CN107951603A (en) * | 2017-12-18 | 2018-04-24 | 上海脉全医疗器械有限公司 | A kind of biodegradable stent system for crotch branch vessel |
| CN108175548A (en) * | 2018-01-25 | 2018-06-19 | 重庆医科大学附属第二医院 | A kind of accurate positioning and submissive iliac vein stent |
| CN110613540A (en) * | 2019-10-24 | 2019-12-27 | 上海唯域医疗科技有限公司 | Blood vessel implantation stent |
| CN110613538A (en) * | 2019-10-24 | 2019-12-27 | 上海唯域医疗科技有限公司 | Blood vessel support capable of positioning |
| CN111096832A (en) * | 2018-12-19 | 2020-05-05 | 上海善迪医疗科技有限公司 | Blood vessel expansion support |
| US11471309B2 (en) | 2016-04-27 | 2022-10-18 | Suzhou Venmed Technology Co., Ltd. | Intravascular stent, preparation method and use thereof |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2724662Y (en) * | 2004-08-17 | 2005-09-14 | 微创医疗器械(上海)有限公司 | Combination and bent at all ldirection type stent with coating |
| CN1726885A (en) * | 2005-07-25 | 2006-02-01 | 哈尔滨工业大学 | TiNi-based drug-eluting stent and preparation method thereof |
| CN1816367A (en) * | 2003-04-30 | 2006-08-09 | 尼普洛株式会社 | Extendable soft stent with excellent follow-up capability to blood vessel |
| CN2917584Y (en) * | 2004-09-30 | 2007-07-04 | 大连理工大学 | Laser engraved Nitinol self-expanding anti-jump bracket |
| CN201200504Y (en) * | 2008-05-04 | 2009-03-04 | 中国人民解放军第二军医大学 | Anti-reflux bile duct metal stent with valve |
| CN102481186A (en) * | 2009-08-14 | 2012-05-30 | 麦德托尼克瓦斯科尔勒公司 | Low profile prosthesis |
| CN103230310A (en) * | 2013-04-19 | 2013-08-07 | 湖南埃普特医疗器械有限公司 | Thoracic aortic aneurysm coated stent and thoracic aortic aneurysm minimally invasive treatment system |
| CN203408130U (en) * | 2013-08-12 | 2014-01-29 | 万瑞飞鸿(北京)医疗器材有限公司 | Self-expansion carotid artery covered stent |
| CN203988521U (en) * | 2014-06-24 | 2014-12-10 | 内蒙古工业大学 | A kind of asymmetric conical intravascular stent |
-
2016
- 2016-04-27 CN CN201610268333.1A patent/CN105726174B/en active Active
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1816367A (en) * | 2003-04-30 | 2006-08-09 | 尼普洛株式会社 | Extendable soft stent with excellent follow-up capability to blood vessel |
| CN2724662Y (en) * | 2004-08-17 | 2005-09-14 | 微创医疗器械(上海)有限公司 | Combination and bent at all ldirection type stent with coating |
| CN2917584Y (en) * | 2004-09-30 | 2007-07-04 | 大连理工大学 | Laser engraved Nitinol self-expanding anti-jump bracket |
| CN1726885A (en) * | 2005-07-25 | 2006-02-01 | 哈尔滨工业大学 | TiNi-based drug-eluting stent and preparation method thereof |
| CN201200504Y (en) * | 2008-05-04 | 2009-03-04 | 中国人民解放军第二军医大学 | Anti-reflux bile duct metal stent with valve |
| CN102481186A (en) * | 2009-08-14 | 2012-05-30 | 麦德托尼克瓦斯科尔勒公司 | Low profile prosthesis |
| CN103230310A (en) * | 2013-04-19 | 2013-08-07 | 湖南埃普特医疗器械有限公司 | Thoracic aortic aneurysm coated stent and thoracic aortic aneurysm minimally invasive treatment system |
| CN203408130U (en) * | 2013-08-12 | 2014-01-29 | 万瑞飞鸿(北京)医疗器材有限公司 | Self-expansion carotid artery covered stent |
| CN203988521U (en) * | 2014-06-24 | 2014-12-10 | 内蒙古工业大学 | A kind of asymmetric conical intravascular stent |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017185529A1 (en) * | 2016-04-27 | 2017-11-02 | 苏州天鸿盛捷医疗器械有限公司 | Vascular stent, preparation method therefor, and application thereof |
| US10695201B2 (en) | 2016-04-27 | 2020-06-30 | Suzhou Venmed Technology Co., Ltd. | Intravascular stent, preparation method and use thereof |
| US11471309B2 (en) | 2016-04-27 | 2022-10-18 | Suzhou Venmed Technology Co., Ltd. | Intravascular stent, preparation method and use thereof |
| CN106176003A (en) * | 2016-07-06 | 2016-12-07 | 苏州天鸿盛捷医疗器械有限公司 | A kind of intravascular stent, its preparation method and application |
| CN106963451A (en) * | 2017-03-29 | 2017-07-21 | 上海心玮医疗科技有限公司 | One kind takes bolt device |
| CN106963451B (en) * | 2017-03-29 | 2024-05-31 | 上海心玮医疗科技股份有限公司 | Thrombolysis device |
| CN107951603A (en) * | 2017-12-18 | 2018-04-24 | 上海脉全医疗器械有限公司 | A kind of biodegradable stent system for crotch branch vessel |
| CN108175548A (en) * | 2018-01-25 | 2018-06-19 | 重庆医科大学附属第二医院 | A kind of accurate positioning and submissive iliac vein stent |
| CN111096832A (en) * | 2018-12-19 | 2020-05-05 | 上海善迪医疗科技有限公司 | Blood vessel expansion support |
| CN110613540A (en) * | 2019-10-24 | 2019-12-27 | 上海唯域医疗科技有限公司 | Blood vessel implantation stent |
| CN110613538A (en) * | 2019-10-24 | 2019-12-27 | 上海唯域医疗科技有限公司 | Blood vessel support capable of positioning |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105726174B (en) | 2018-06-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105726174A (en) | Intravascular stent and preparation method and application thereof | |
| CN106176003B (en) | A kind of intravascular stent, preparation method and application | |
| CN105726178A (en) | Intravascular stent and preparation method and application thereof | |
| CN105796220A (en) | Intravascular stent and preparation method and application thereof | |
| WO2011131115A1 (en) | Stent for bifurcated vessel | |
| CN103550017A (en) | Intravascular stent applicable to conical blood vessel | |
| CN207168613U (en) | A kind of intravascular stent | |
| CN111374809A (en) | A vertebral artery stent | |
| US10695201B2 (en) | Intravascular stent, preparation method and use thereof | |
| CN206566053U (en) | A kind of effective biological support of coronary blood | |
| US11471309B2 (en) | Intravascular stent, preparation method and use thereof | |
| CN103300951A (en) | Vertebral artery stent | |
| CN203122692U (en) | Intracranial arterial stent | |
| CN216294346U (en) | Vertebral artery stent system | |
| CN203425071U (en) | Blood vessel stent suitable for conical blood vessel | |
| CN204411043U (en) | A kind of progressive thickness coronary artery bracket being applicable to the tortuous angulation pathological changes of coronary artery | |
| CN206342572U (en) | A kind of intravascular stent | |
| WO2009052703A1 (en) | Nested stent in body lumen | |
| CN107874877A (en) | Aorta tectorial membrane stent | |
| CN206534738U (en) | Aorta tectorial membrane stent | |
| CN105796219A (en) | Intravascular stent and preparation method and application thereof | |
| CN206372164U (en) | A kind of intravascular stent | |
| WO2019075790A1 (en) | Blood vessel stent | |
| CN204671319U (en) | A kind of conical support graft being applicable to the band distal end bare bracket of dissection of aorta | |
| CN219230280U (en) | Vascular stent |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CP03 | Change of name, title or address |
Address after: Rooms 202, 501, and 502, Building 7, No. 188 Fuchunjiang Road, High tech Zone, Suzhou City, Jiangsu Province, 215000 Patentee after: SUZHOU VENMED TECHNOLOGY Co.,Ltd. Country or region after: China Address before: 215163 south 2nd floor, building 11, No.8 Jinfeng Road, science and Technology City, Suzhou high tech Zone, Jiangsu Province Patentee before: SUZHOU VENMED TECHNOLOGY Co.,Ltd. Country or region before: China |
|
| CP03 | Change of name, title or address |