CN105687788A - Pharmaceutical composition capable of softening blood vessels and application thereof - Google Patents

Abstract

The invention provides a pharmaceutical composition capable of softening blood vessels. The pharmaceutical composition is prepared from leaves of crataegus pinnatifida var. major, radix salvia miltiorrhiza, scorpions, squama manis, radix achyranthis bidentatae, rhizoma et radix notopterygii, rhizoma atractylodis macrocephalae, tribulus terrestris, radix notoginseng, capillary wormwood herb, white mulberry root-bark, caulis spatholobi, ramulus uncariae cum uncis, flos carthami, Chinese crossostepium leaves, poria cocos, snow lotus herb, folium cortex eucommiae, radix angelica sinensis, rhizoma chuanxiong, pericarpium citri reticulatae, rhizoma polygoni cuspidate, lumbricus, herba portulacae, folium ginkgo, kudzuvine roots, semen cassia, fructus crataegi and rhizoma gastrodiae. According to the pharmaceutical composition, compatibility is in compliance with the 'monarch, minster, assistant and guide' principle of traditional Chinese medicine, gives prominence to the key points and is comprehensive and reasonable, by orally taking the medicine, the viscera functions can be regulated, blood fat can be lowered, the blood vessels can be softened, the blood quality can be made to be clear and thin, the blood flow activity can be improved, and the blood vessel softening effect is obvious; in addition, the raw materials are rich, a preparation technology is simple, no toxic or side effect is generated, the price is low, and the good application prospect on softening the blood vessels and treating and preventing high blood pressure, high blood fat and high blood sugar, especially the high blood fat is achieved.

Description

The pharmaceutical composition of a kind of vessel softening and application thereof

Technical field

The invention belongs to pharmaceutical technology field, relate to a kind of Chinese medicine composition, be specifically related to pharmaceutical composition and the application thereof of a kind of vessel softening。

Background technology

Due to economical day by day flourishing, the continuous lifting of modern's living standard, cause people too much have deep love for enjoy, do not notice that the life style of oneself, behavioural habits, diet are had a liking for, thus the disease caused。Society with fast rhythm lives, the operating pressure of keen competition, the physical and mental health of modern is caused serious threat, unreasonable plus long-term diet, that is: essence grain replaces coarse grain completely, the pesticide that remains in substantial amounts of three-hypers (high heat, high protein, higher fatty acid), the absorption of more than three (preservative is many, flavour enhancer is many, hormone many) food and food, chemical fertilizer stockpiling in vivo, add air, pollution of waterhead and quantity of motion less than normal, the fat affluenza just having become city family with diabetes。Being what has statistics about three-hypers, in the Chinese ten big causes of death, the mortality rate relevant to metabolic disease is just up to 35.7%, and the death toll relevant to " three high " also accounts for the 27% of total death toll。" three-hypers disease " refers to hypertension, hyperglycemia (diabetes) and hyperlipidemia。Hyperlipidemia can cause blood vessel embolism；Hypertension can cause cerebral hemorrhage and rupture of blood vessel in brain；Hyperglycemia can cause diabetes。Generally along with obesity。They are that " affluenza " is derived from modern society, it is possible to individualism, it is also possible to interrelated。As: diabetes patient is easy to suffer from hypertension or hyperlipidemia simultaneously, and hyperlipidemia is the principal element of arteriosclerosis formation and development, and arteriosclerotic's blood vessel elasticity difference aggravation blood pressure raises, so the later stage all defines " three-hypers disease "。World Health Organization (WHO) once clearly proposed, it is prevented that the first line of defence of cardiovascular diseases reduces " three high " exactly and controls " three high "。A lot of diabetes patients are with hyperlipemia, and therefore diabetes and hyperlipemia, people generally call that sister is sick, and think that hyperlipidemia is the secondary disease of diabetes。The diabetic of about 40% has disorders of lipid metabolism according to statistics。It is characterized in that triglyceride increases to reduce with high density lipoprotein。

Hyperlipidemia is a kind of systemic disease, and a large amount of research datas show, hyperlipidemia is apoplexy, coronary heart disease, myocardial infarction, cardiac sudden death independently important risk factor。Additionally, hyperlipidemia is also the important risk factor promoting hypertension, impaired glucose tolerance, diabetes。Hyperlipidemia can also result in fatty liver, liver cirrhosis, cholelithiasis, pancreatitis, retinal hemorrhage, blind, peripheral vascular disease, limping, hyperuricemia。

Between nearly 20 years, the food consumption of people and diet structure there occurs very big change, and the sickness rate that the most active effects thus brought is exactly hyperlipidemia constantly promotes, and progressively occurs becoming younger。City white collar rhythm of life is fast, and operating pressure is big, and diet is irregular, lacks motion, and the people of about 40% is hyperlipidemia。According to statistics, China's hyperlipidemia number of patients is up to 1.6 hundred million, and expert estimates, in the middle of the adult in more than 30 years old, the whole nation, the sickness rate of hyperlipidemia is at about 10%-20%, and hyperlipemia number is up to 90,000,000。Investigation display, China has 250 ten thousand to 300 ten thousand people to die from cardiovascular diseases every year, and this kind of disease has become harm China city and the major causes of death of rural population health。Talking about cardiovascular disease, a lot of people know relevant with hypertension, but it practice, hide at us internal, the moment threatens also more hidden, more severe " killer " of our vascular health, and it is exactly hyperlipidemia。Expert points out, dyslipidemia is one of important risk factor of the medium cardiovascular and cerebrovascular disease of coronary heart disease, heart infarction and ischemic cerebral apoplexy。

Young generation " senile disease " is increased year by year in recent years。Arteriosclerotic cardiovascular and cerebrovascular disease occurs gradually, many and bad life style, the accumulation environmental pollution of vivotoxin causes that hyperlipidemia cohesion is relevant, life, work strain, smoking, excessive drinking, overnutrition, blood thickness, abnormal composition (toxin) etc. in blood, severe overweight, form arteriosclerosis, the thrombosis at vascular inflammation and initial stage, mid-term, the dysemia phase, teenager is cradle even, mid-term, angiopathy becomes the hemodynamic change phase, the young and the middle aged can occur, late period, stage of exhaustion (a sick phase) angiemphraxis of visceral organ injury phase or life is serious, cardiovascular and cerebrovascular disease is caused more than 50%, peripheral vessels occurs, form serious hypertension, severe patient life exhaustion。

Sclerosis of blood vessels blood thickness is the source of ten thousand diseases。The arteriosclerosis that thus causes, blood high viscosity syndrome, heart disease, heart infarction, cerebral infarction, apoplexy, hypertension, diabetes, tumor etc. are in being gradually increasing trend。It is especially prominent that high blood viscosity thick initiation three-hypers, high blood viscosity cause hyperlipidemia, high blood viscosity to cause hypertension, high blood viscosity to accelerate diabetic complication。Western medicine current therapeutic effect in treatment sclerosis of blood vessels blood thickness is unsatisfactory, price is high, and generally all it is attended by serious side effect, have a strong impact on the healthy of patient, Chinese medicine has unique advantage because its side effect is little in treating such chronic disease, but lacks effective prescription of vessel softening at present。

Summary of the invention

The present invention is directed to weak point of the prior art, it is provided that the pharmaceutical composition of a kind of vessel softening and application thereof, this pharmaceutical composition technique is simple, and cost is low, has no side effect, and has significant curative effect in vessel softening。

The above-mentioned purpose of the present invention is realized by following technical proposals:

The pharmaceutical composition of a kind of vessel softening, the crude drug of described pharmaceutical composition is made up of crataegus pin natifida var. Major leaf, Radix Salviae Miltiorrhizae, Scorpio, Squama Manis, Radix Achyranthis Bidentatae, Rhizoma Et Radix Notopterygii, the Rhizoma Atractylodis Macrocephalae, Fructus Atriplicis Sibiricae, Radix Notoginseng, Herba Artemisiae Scopariae, Cortex Mori, Caulis Spatholobi, Ramulus Uncariae Cum Uncis, Flos Carthami, Folium Crossostephii Chinensis, Poria, Herba Saussureae Involueratae, Folium Eucommiae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Pericarpium Citri Reticulatae, Rhizoma Polygoni Cuspidati, Pheretima, Herba Portulacae, Folium Ginkgo, Radix Puerariae, Semen Cassiae, Fructus Crataegi, Rhizoma Gastrodiae。

In a preferred embodiment, make described pharmaceutical composition raw material composition and parts by weight be: crataegus pin natifida var. Major leaf 12-20 part, Scorpio 10-16 part, Radix Angelicae Sinensis 3-8 part, Squama Manis 5-12 part, Radix Achyranthis Bidentatae 12-17 part, Radix Salviae Miltiorrhizae 7-12 part, Flos Carthami 4-9 part, Rhizoma Atractylodis Macrocephalae 15-20 part, Fructus Atriplicis Sibiricae 10-15 part, Herba Artemisiae Scopariae 8-12 part, Cortex Mori 2-5 part, Rhizoma Et Radix Notopterygii 3-7 part, Caulis Spatholobi 11-14 part, Ramulus Uncariae Cum Uncis 9-15 part, Rhizoma Chuanxiong 3-6 part, Folium Crossostephii Chinensis 8-13 part, Herba Saussureae Involueratae 3-5 part, Folium Eucommiae 1-3 part, Pericarpium Citri Reticulatae 5-10 part, Radix Notoginseng 5-10 part, Rhizoma Polygoni Cuspidati 13-16 part, Pheretima 3-10 part, Herba Portulacae 8-13 part, Folium Ginkgo 3-5 part, Poria 1-3 part, Radix Puerariae 5-10 part, Semen Cassiae 3-6 part, Fructus Crataegi 8-13 part, Rhizoma Gastrodiae 3-5 part。

In a preferred embodiment, make described pharmaceutical composition raw material composition and parts by weight be: 12 parts of crataegus pin natifida var. Major leaf, Scorpio 16 parts, Radix Angelicae Sinensis 3 parts, Squama Manis 12 parts, Radix Achyranthis Bidentatae 12 parts, Radix Salviae Miltiorrhizae 10 parts, 9 parts of Flos Carthami, the Rhizoma Atractylodis Macrocephalae 15 parts, Fructus Atriplicis Sibiricae 15 parts, Herba Artemisiae Scopariae 8 parts, Cortex Mori 5 parts, Rhizoma Et Radix Notopterygii 3 parts, Caulis Spatholobi 14 parts, Ramulus Uncariae Cum Uncis 9 parts, Rhizoma Chuanxiong 6 parts, Folium Crossostephii Chinensis 8 parts, Herba Saussureae Involueratae 5 parts, Folium Eucommiae 1 part, Pericarpium Citri Reticulatae 10 parts, Radix Notoginseng 5 parts, Rhizoma Polygoni Cuspidati 16 parts, Pheretima 10 parts, Herba Portulacae 8 parts, Folium Ginkgo 5 parts, 1 part of Poria, Radix Puerariae 10 parts, Semen Cassiae 6 parts, Fructus Crataegi 8 parts, 3 parts of Rhizoma Gastrodiae。

In a preferred embodiment, make described pharmaceutical composition raw material composition and parts by weight be: 20 parts of crataegus pin natifida var. Major leaf, Scorpio 10 parts, Radix Angelicae Sinensis 8 parts, Squama Manis 5 parts, Radix Achyranthis Bidentatae 17 parts, Radix Salviae Miltiorrhizae 12 parts, 4 parts of Flos Carthami, the Rhizoma Atractylodis Macrocephalae 20 parts, Fructus Atriplicis Sibiricae 10 parts, Herba Artemisiae Scopariae 12 parts, Cortex Mori 2 parts, Rhizoma Et Radix Notopterygii 7 parts, Caulis Spatholobi 11 parts, Ramulus Uncariae Cum Uncis 15 parts, Rhizoma Chuanxiong 3 parts, Folium Crossostephii Chinensis 13 parts, Herba Saussureae Involueratae 3 parts, Folium Eucommiae 3 parts, Pericarpium Citri Reticulatae 5 parts, Radix Notoginseng 10 parts, Rhizoma Polygoni Cuspidati 13 parts, Pheretima 3 parts, Herba Portulacae 13 parts, Folium Ginkgo 3 parts, 3 parts of Poria, Radix Puerariae 5 parts, Semen Cassiae 4 parts, Fructus Crataegi 10 parts, 4 parts of Rhizoma Gastrodiae。

In a preferred embodiment, make described pharmaceutical composition raw material composition and parts by weight be: 13 parts of crataegus pin natifida var. Major leaf, Scorpio 11 parts, Radix Angelicae Sinensis 4 parts, Squama Manis 6 parts, Radix Achyranthis Bidentatae 13 parts, Radix Salviae Miltiorrhizae 7 parts, 5 parts of Flos Carthami, the Rhizoma Atractylodis Macrocephalae 18 parts, Fructus Atriplicis Sibiricae 11 parts, Herba Artemisiae Scopariae 9 parts, Cortex Mori 4 parts, Rhizoma Et Radix Notopterygii 6 parts, Caulis Spatholobi 12 parts, Ramulus Uncariae Cum Uncis 13 parts, Rhizoma Chuanxiong 4 parts, Folium Crossostephii Chinensis 9 parts, Herba Saussureae Involueratae 4 parts, Folium Eucommiae 2 parts, Pericarpium Citri Reticulatae 6 parts, Radix Notoginseng 6 parts, Rhizoma Polygoni Cuspidati 14 parts, Pheretima 5 parts, Herba Portulacae 10 parts, Folium Ginkgo 4 parts, 2 parts of Poria, Radix Puerariae 6 parts, Semen Cassiae 5 parts, Fructus Crataegi 12 parts, 3 parts of Rhizoma Gastrodiae。

In a preferred embodiment, make described pharmaceutical composition raw material composition and parts by weight be: 17 parts of crataegus pin natifida var. Major leaf, Scorpio 15 parts, Radix Angelicae Sinensis 7 parts, Squama Manis 11 parts, Radix Achyranthis Bidentatae 16 parts, Radix Salviae Miltiorrhizae 8 parts, 8 parts of Flos Carthami, the Rhizoma Atractylodis Macrocephalae 16 parts, Fructus Atriplicis Sibiricae 14 parts, Herba Artemisiae Scopariae 11 parts, Cortex Mori 3 parts, Rhizoma Et Radix Notopterygii 5 parts, Caulis Spatholobi 13 parts, Ramulus Uncariae Cum Uncis 14 parts, Rhizoma Chuanxiong 5 parts, Folium Crossostephii Chinensis 12 parts, Herba Saussureae Involueratae 3 parts, Folium Eucommiae 1 part, Pericarpium Citri Reticulatae 10 parts, Radix Notoginseng 9 parts, Rhizoma Polygoni Cuspidati 13 parts, Pheretima 7 parts, Herba Portulacae 11 parts, Folium Ginkgo 3 parts, 1 part of Poria, Radix Puerariae 10 parts, Semen Cassiae 4 parts, Fructus Crataegi 11 parts, 4 parts of Rhizoma Gastrodiae。

In a preferred embodiment, make described pharmaceutical composition raw material composition and parts by weight be: 15 parts of crataegus pin natifida var. Major leaf, Scorpio 12 parts, Radix Angelicae Sinensis 5 parts, Squama Manis 9 parts, Radix Achyranthis Bidentatae 15 parts, Radix Salviae Miltiorrhizae 9 parts, 7 parts of Flos Carthami, the Rhizoma Atractylodis Macrocephalae 19 parts, Fructus Atriplicis Sibiricae 13 parts, Herba Artemisiae Scopariae 10 parts, Cortex Mori 4 parts, Rhizoma Et Radix Notopterygii 4 parts, Caulis Spatholobi 11 parts, Ramulus Uncariae Cum Uncis 11 parts, Rhizoma Chuanxiong 5 parts, Folium Crossostephii Chinensis 10 parts, Herba Saussureae Involueratae 5 parts, Folium Eucommiae 3 parts, Pericarpium Citri Reticulatae 8 parts, Radix Notoginseng 8 parts, Rhizoma Polygoni Cuspidati 14 parts, Pheretima 9 parts, Herba Portulacae 12 parts, Folium Ginkgo 5 parts, 3 parts of Poria, Radix Puerariae 8 parts, Semen Cassiae 6 parts, Fructus Crataegi 9 parts, 5 parts of Rhizoma Gastrodiae。

In a preferred embodiment, make described pharmaceutical composition raw material composition and parts by weight be: 19 parts of crataegus pin natifida var. Major leaf, Scorpio 14 parts, Radix Angelicae Sinensis 6 parts, Squama Manis 7 parts, Radix Achyranthis Bidentatae 14 parts, Radix Salviae Miltiorrhizae 9 parts, 6 parts of Flos Carthami, the Rhizoma Atractylodis Macrocephalae 17 parts, Fructus Atriplicis Sibiricae 13 parts, Herba Artemisiae Scopariae 10 parts, Cortex Mori 4 parts, Rhizoma Et Radix Notopterygii 4 parts, Caulis Spatholobi 11 parts, Ramulus Uncariae Cum Uncis 11 parts, Rhizoma Chuanxiong 5 parts, Folium Crossostephii Chinensis 10 parts, Herba Saussureae Involueratae 5 parts, Folium Eucommiae 3 parts, Pericarpium Citri Reticulatae 8 parts, Radix Notoginseng 8 parts, Rhizoma Polygoni Cuspidati 14 parts, Pheretima 4 parts, Herba Portulacae 9 parts, Folium Ginkgo 5 parts, 3 parts of Poria, Radix Puerariae 8 parts, Semen Cassiae 3 parts, Fructus Crataegi 8 parts, 5 parts of Rhizoma Gastrodiae。

In a preferred embodiment, described Chinese medicine composition is prepared in following manner:

(1) each medical material of components by weight percent in the arbitrary described pharmaceutical composition of claim 2-8 is taken, add in the ethanol of 5-10 times amount and soak 1-2 hour, heating extraction 2 times, each 1-2 hour, removes supernatant, united extraction liquid, 100-120 order filters, the ultrafiltration post ultrafiltration that molecular weight is 5000-10000 then through damming, the extractum of 1.36 when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C, heating is concentrated into paste, stand for standby use；

(2) being put in 10 times amount water by the medicinal residues that ethanol extraction is crossed, be then placed in extraction pot heated and boiled 1 hour, filter, filtrate is standby；Filtering residue adds water, second time heating, boils 45 minutes, filters, and filtrate is standby；

(3) 2 filtrates in step (2) being combined, by filtered through gauze, add 50-60% ethanol in residue, 60 DEG C-70 DEG C are continued lixiviate 2h, every 10min and stir once, and filtered through gauze merges lixiviating solution, is condensed into pasty state；

(4) the pastel decompression recycling ethanol that step (1) paste that obtains of concentration and step (3) obtained to be concentrated into liquor strength be 0.6-0.7g crude drug/mL, after sucking filtration, the relative density of filtrate is about 1.0-1.1 when 20 DEG C；It is centrifuged under the rotating speed of 3000r/min；At 60 DEG C of-80 DEG C of spray drying, obtain dry extract；

(5) dry extract that step (4) prepares is pulverized, add suitable amount of sucrose, dextrin mixing, with ethanol for wetting agent, granulate, dry, granulate, granule can be prepared；Or the dry extract that step (4) prepares be dry, pulverize, make powder；Or dry extract step (4) prepared is pulverized, add appropriate micropowder silica gel, α-galactose mixing, with ethanol for wetting agent, granulate, dry, granulate, encapsulated, prepare capsule；Or dry extract step (4) prepared is pulverized, add suitable amount of sucrose, dextrin mixing, with ethanol for wetting agent, granulate, dry, granulate, tabletting, prepare tablet；Or to above-mentioned steps (4) obtain centrifugal after concentrated solution in add suitable amount of sucrose, essence mixing, sterilizing, fill, prepare medicinal liquid agent。

The invention still further relates to the application in vessel softening medicine of a kind of described pharmaceutical composition。

The pharmaceutical composition of vessel softening provided by the present invention, it gives full play to the property of medicine of each component with common Chinese herbal medicine for raw material:

Contained by crataegus pin natifida var. Major leaf, crataegus pin natifida var. Major leaf flavonoids has pharmacological action widely, is particularly useful for cardiovascular system。Experimentation shows, crataegus pin natifida var. Major leaf flavonoids has blood pressure lowering, reduces peripheral vascular resistance, coronary artery dilator, increase coronary flow, reduce myocardial oxygen consumption, heart tonifying, increase cardiac output, resist myocardial ischemia, and antiplatelet aggregation, improves hemorheological property, eliminates oxygen-derived free radicals, drops the pharmacological actions such as excellent and constitution, enhancing hypoxia-bearing capability and diuresis。It is all safe and effective for being clinically used for preventing and treating angina pectoris, hypertension, arrhythmia and hyperlipemia, atherosclerosis etc., is worthy of popularization。Crataegus pin natifida var. Major leaf is very abundant at China various places particularly Resources of The West Area In China, has significantly high Development volue。

Radix Salviae Miltiorrhizae, bitter, it is slightly cold。GUIXIN, Liver Channel。Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness。For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, chest and abdomen twinge, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia。For costa sternales hypochondriac pain, rheumatic arthralgia, lump in the abdomen lumps, and skin infection swells and ache, and tumbling down is grieved, menoxenia, amenorrhea dysmenorrhea, puerperal stasis of blood pain etc.。Treatment costa sternales pain, lump in the abdomen caking, and menoxenia, amenorrhea dysmenorrhoea has good effect。" detailed outline " carries: Radix Salviae Miltiorrhizae, and by " the sensible opinion of married woman " cloud, SIWU TANG controls gynecopathy, pays no attention to antenatal puerperal, how many through water, and all generally applicable, only taste Radix Salviae Miltiorrhizae dissipates, and cures mainly same。Lid Radix Salviae Miltiorrhizae can break stagnated blood, mends fresh blood, peaceful tire, and fall stillborn fetus, only metrorrhagia dysentery, regulating menstruation arteries and veins。Main Compositions of Radix Salviae Miltiorrhizae TANSHINONES has expansion blood vessel, improves circulation, releases the effects such as intravascular coagulation, has effect of invigorating blood circulation trace, and can promote that liver blood circulates, is beneficial to liver cell regeneration。

Scorpio, edible, medicinal history is long。The primary medicinal component of Scorpio is charybdotoxin, and according to Compendium of Material Medica and " Chinese Pharmacopoeia " load, Scorpio has " spasmolytic that relieves dizziness, high fever, infantile convulsions, epilepsy, etc., antiinflammatory counteracting toxic substances, removing obstruction in the collateral to relieve pain " function；Cure mainly diseases such as " infantile convulsion, tic spasm, dermatosis, cardiovascular and cerebrovascular disease, inflammation, hepatitis B, tumors "。Scorpio is also a kind of high-grade delicious food, nutritious, the preventing and curing diseases of food, enhancing immunity and anti-ageing function of waiting for a long time。

Squama Manis, part of being used as medicine, the scute of Squama Manis, effect and effect: blood circulation promoting and dispersing pathogen accumulation；Stimulate the menstrual flow stimulating milk secretion；Eliminating carbuncle is burst hard。Main blood stasis amenorrhea；Lump in the abdomen；Rheumatic arthralgia；Agalactia；Carbuncle；Scrofula。For amenorrhea abdominal mass, galactostasis, carbuncle sore tumefacting virus, arthralgia, numbness contracture。

Radix Achyranthis Bidentatae: bitter in the mouth, acid；Property is put down, and returns liver；Kidney channel, has invigorating the liver and kidney；Bone and muscle strengthening；Promoting blood circulation to restore menstrual flow；Ignite (blood) descending；Effect of inducing diuresis for treating stranguria syndrome, cures mainly soreness of waist and knee joint；Flaccidity and weakness of the lower limbs；Amenorrhea due to stagnation of blood；Dysmenorrhea；Puerperal abdominal pain due to blood stasis；Lump in the abdomen；Retention of placenta；Pyretic stranguria；Stranguria with blood；Traumatic injury；Carbuncle malignant boil；Laryngopharynx swelling and pain etc. are demonstrate,proved。

Rhizoma Et Radix Notopterygii, acrid in the mouth；Bitter；Warm in nature。Dissipate exterior cold；Wind-damp dispelling；Profit joint；Pain relieving。Main affection of exogenous wind-cold；Have a headache lossless；Edema due to wind pathogen edema；Sore swollen toxin。For impotence and seminal emission, enuresis frequent micturition, chills and pain of the waist and kness, suffer from a deficiency of the kidney and breathe heavily, Diarrhoea；External curing vitiligo, alopecia areata。Induce sweat cold expelling, expelling wind and dampness, pain relieving。

Rhizoma Atractylodis Macrocephalae bitter in the mouth, sweet, temperature。Return spleen, stomach warp。Cure mainly invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive。For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement。Oncocyte is had cytotoxicity by the Rhizoma Atractylodis Macrocephalae, can reduce the rate of increase of oncocyte, lowers the aggressive of tumor tissue, improves the ability of body antitumor reaction。Mice ehrlich carcinoma, lymphosarcoma ascitic type, the esophageal carcinoma (Ecal09), sarcoma 180 etc. are had inhibitory action by Rhizoma Atractylodis Macrocephalae volatile oil。Atractylodes lactone B lumbar injection is to the murine sarcoma people。Also effect is significantly inhibited。" property of medicine opinion " carries it: monarch, and sweet in the mouth is pungent, nontoxic。The main big migratory arthralgia of energy, diarrhea due to disorder of qi for many years, trusted subordinate's distending pain, the broken dyspepsia that disappears, appetizing, remove sputum, except cold and heat, let out under only。Interarea light is pleased, and preserves youthful looks, de-black。Swelling of harnessing the river is full, tells vomiting, cold type of pain in abdomen, vomits and diarrhoea incessantly, and insufficiency of stomach-QI cold-dysentery。

Fructus Atriplicis Sibiricae is that annual or herbaceos perennial Fructus Tribuli TribulusterrestrisL the mature fruit of zygophyllaceae is bitter, pungent, flat, enters Liver Channel。Suppressing the hyperactive liver resolving depression, dispelling pathogenic wind for improving eyesight。Have a headache for dizziness due to hyperactivity of liver-YANG, hypochondriac pain due to stagnation of liverQI, headache due to pathogenic wind-heat, conjunctival congestion and swelling pain, the disease such as skin pruritus。

Radix Notoginseng: the sweet mildly bitter flavor of Radix Notoginseng property, warm in nature, return liver, stomach through being used as medicine with root, root stock。Rare Chinese medicine, raw with can hemostasia and dissipation blood stasis, reducing swelling and alleviating pain, there is good hemostasia effect, significant hemopoietic function；Tightening and improving Coronary microcirculation, Radix Notoginseng is used as medicine with a long history, acts on the peculiar treasured being considered as in medicine by ancient Chinese medicine doctor, therefore has the saying of " Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) "。" taste is micro-sweet and bitter, quite like the taste of Radix Ginseng for Radix Notoginseng。" " all canes flutter trauma, the dripping person of blood stasis, chew namely stopping of rotten net for catching birds or fish immediately, and namely bruise person dissipate。If during by cane, first taking one, two money, then the blood not centre of punch, especially should taking it after cane, puerperal, clothes were also good。On the whole this medicine temperature, sweet and slightly bitter taste, and sun is bright, the medicine of cloudy blood system of fainting, therefore all disorders of blood can be controlled "。" book on Chinese herbal medicine is looked for the truth " is recorded: " Radix Notoginseng, common people only know function hemostasis and pain-relieving。Hardly realizing that pain aches work because of blood stasis, because of deposited dissipating, blood stops blood。Radix Notoginseng abnormal smells from the patient hardship temperature, can in its blood stasis of blood systemization。" Radix Notoginseng can increase coronary flow, decreased heart rate, reduce myocardial oxygen consumption, increase cardiac muscle oxygen-resistant ability, improve microcirculation, release the effect of smooth muscle spasm。

Herba Artemisiae Scopariae: bitter in the mouth, pungent, cold nature。Return spleen, stomach, liver, gallbladder meridian。Function cures mainly: clearing away damp-heat, jaundice eliminating subcutaneous ulcer。For jaundice oliguria, eczema pruritus；Infectious jaundice type hepatitis。" herbal classic ": the raw pathogenic heat gas of main air, accumulation of heat jaundice。" not Lu ": control the whole body jaundice, dysuria, except feverish sensation in the head, remove mass in the large intestine。Supplement to the Herbal: get round by bribery, goes stagnant heat, and typhoid fever uses it。" medical center bun is wanted ": hard kidney, dry spleen wets, and goes strongly fragrant, antipyretic。" book on Chinese herbal medicine is new again ": pathogenic fire purging, suppressing the hyperactive liver, reduces phlegm, cough-relieving diaphoresis, dampness removing, detumescence, treats the skin ulcer all poison of fire。

Cortex Mori is the root bark of moraceae plants Mulberry MorusalbaL.。Main product in Anhui, Henan, Zhejiang, Jiangsu, the ground such as Hunan。Effect: eliminating pathogen from the lung for relieving asthma, inducing diuresis to remove edema。For diseases such as lung-heat cough with asthma, the edema of the face, dysuria。" property of medicine opinion ": make, flat。Controlling lung qi dyspnea with fullness of the chest, aqueous vapor edema, main wound is exhausted, dredging water passages, and disappear aqueous vapor, and asthenia exopathogenic heat is had a headache, interior tonifying for the deficiency。" Japan hanako materia medica ": temperature, in tune, the therapeutic method to keep the adverse QI flowing downwards。Expectorant is quenched the thirst, profit intestine and small intestine, appetizing, and lower food kills abdomen and hides worm, and only cholera is vomited and diarrhoea。

Caulis Spatholobi, property is bitter, sweet, temperature。Return liver, kidney channel, enrich blood, invigorate blood circulation, dredging collateral。For menoxenia, blood deficiency and yellow complexion, paralysis and numbness, rheumatic arthralgia relaxing muscles and tendons to promote blood circulation；Nourishing blood for regulating menstruation, supplementary Amplifications of the Compendium of Materia Medica carries it can cure numb hand and foot；Quadriplegia；Rheumatic arthralgia；Women has through uncomfortable；Dysmenorrhea。External is gynecological's good medicine of activating blood circulation to dissipate blood stasis。

Ramulus Uncariae Cum Uncis, sweet in the mouth, cool in nature。Enter liver, heart channel。Energy heat clearing away suppressing the hyperactive liver, relieve dizziness, high fever, infantile convulsions, epilepsy, etc. arresting convulsion。Cure mainly pediatric epilepsy scared, adult's slight Hypertension, dizzy, dizzy, married woman's eclamposia。Its pharmacological action has sedation and hypotensive effect。

Flos Carthami is warm in nature, acrid in the mouth。Function cures mainly and is applied to invigorate blood circulation latus rectum, eliminating stasis to stop pain。For amenorrhea, dysmenorrhea, lochia, lump in the abdomen mass in the abdomen, traumatic injury。" book on Chinese herbal medicine converge with speech ": Flos Carthami, removing blood stasis, promoting the circulation of blood and blood, tune blood medicine also。Main tire produces all kinds of diseases and ailments because blood is for suffering from, or the tired bruise of blood, and coma is in silence；Or lochia robs the heart, umbilicus angina abdominis；Or drop slurry difficulty is raw,；Or afterbirth does not fall, dead fetus in the uterus, is all just before giving birth all cards, and non-Flos Carthami can not be controlled。If puerperal blood faints, locked mouth refer to hold in the hand；Or heresy enters blood room, delirium is gone mad；Or blood is vexed interior swollen, sudden syncope with rigidity as extremely, is all cards in puerperal, and non-Flos Carthami can not be determined。All as obstructed in amenorrhea and cold and heat are handed over and are made, or expired stomachache and purple black dripping, or injury from falling down and the QI and blood stasis of blood amass, or skin infection sufferings and swollen uneasiness of bursting, it is the card of all disharmony between QI and blood, non-Flos Carthami can not be adjusted, Flos Carthami promoting blood circulation to restore menstrual flow, reducing swelling and alleviating pain, there are inhibition thrombosis, antiinflammatory, analgesic effect, there is the vasoconstrictive effect eliminating epinephrine, norepinephrine, have " tonneau passages through which vital energy circulates " to act on。

Folium Crossostephii Chinensis: high and cold Folium Crossostephii Chinensis and coreopsis tinctoria have rubbish in efficient blood fat reducing, vessel softening, removing body; reach the body fluid balance of human body, improve painstaking effort output, increase myocardial oxygen delivery amount; coronary heart disease, hyperlipidemia, diabetes are had special curative effect by the normal physiological function of protection ischemic myocardium。

Poria sweet in the mouth, light, property are put down, and are used as medicine and have the function of promoting diuresis to eliminate damp pathogen, strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming。Modern medicine study: Poria energy enhancing human body immunity function, pachyman has obvious antitumor and protects the liver dirty effect。Poria slightly sweet flavor is put down, and enters the heart, lung, spleen channel。There is eliminating dampness and diuresis, invigorating the spleen and regulating the stomach, effect of mind tranquilizing and the heart calming。Dysuria, edema distension, phlegm retention cough with dyspnea, vomiting, malignant histocytosis can be controlled, have loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful disease such as grade。The diuretic of Poria, is reached by strong activating the spleen pulmonary function, different from the Chinese medicine of other direct diuretic。For diarrhea due to hypofunction of the spleen, leukorrhagia Poria can spleen invigorating, again can eliminating dampness by diuresis, for having loose bowels caused by insufficiency of the spleen dysfunction of the spleen in transportation and transformation, leukorrhagia, application Poria has the effect of giving consideration to both the incidental and fundamental, often and the compatibility such as Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae。Can be used as tonifying the lung spleen, control the adjuvant of the deficiency of vital energy。

Herba Saussureae Involueratae: Herba Saussureae Involueratae has physiologically active effective ingredient。Wherein umbelliferone have significantly antibacterial, blood pressure lowering is calm, spasmolysis；Have and dispel the wind, antiinflammatory, pain relieving, eliminate the phlegm and antitumor action, can the growth of anticancer, clinical have certain curative effect with breast carcinoma especially in order to treat cancer, and skin carcinoma, leukemia and what king's evil etc. are also had certain effect。To the special effect of gout acute attack。

Folium Eucommiae is the dried leaves of Eucommiaceae plant Cortex Eucommiae EucommiaulmoidesOliv.。Summer, season in autumn two branch and leaf luxuriant time gather, dry or oven drying at low temperature。Micro-pungent, temperature。Return liver, kidney channel。Function with cure mainly: invigorating the liver and kidney, bone and muscle strengthening。For deficiency of the liver and kindey, having a dizzy spell, soreness of waist and knee joint, muscles and bones flaccidity is soft。Effect to cardiovascular system, is significantly increased the effect of coronary flow to action of the heart Folium Eucommiae water decoction-alcohol sedimentation liquid 0.2g to guinea pig isolated heart tool。Rabbit intravenous 20g/kg, the ST section that intravenous isoproterenol is caused is raised and the change of T ripple does not have antagonism。After hypotensive effect anesthetized dog and cat intravenous Folium Eucommiae water decoction 0.4g/kg, blood pressure declines rapidly, namely gos up gradually after maintaining 5 minutes；During the above dosage of intravenous 1g/kg, blood pressure is remarkably decreased, and can maintain the long period。Alcohol extract also has a hypotensive effect, but Amplitude of Hypotensive and hold time all poor than water decoction。The drop test of anesthetized dog and cat all proves, Folium Eucommiae water decoction and alcohol extract repeat Bolos intravenous administration in a short time can produce tachylaxis, and successive administration pressure reduction effect even can not occur 3-4 time。Water decoction and the 65% ethanol extract 6g/kg intravenous of Folium Eucommiae all can cause rabbits blood pressure to be decreased obviously。The aqueous solution of Folium Eucommiae, alcoholic solution, ethereal solution and each composition such as saccharide, alkaloid of process purification, aucubin, chlorogenic acid, to rabbit intravenous, all have hypotensive effect in various degree。

Radix Angelicae Sinensis, its sweet in the mouth and weigh, therefore specially can enrich blood, its gas is light and pungent, therefore again can promoting the circulation of blood, invigorating middle warmer has, has benefit in row, the gas medicine in sincere blood, the also panacea in blood。Then mending to mend of about assistant, therefore nutrition blood can be supported, QI invigorating spermatogenesis, settling five organs, strong body, benefit mind, all tangible deficient diseases, unsuitable without institute。Assistant to attack, lead to, therefore pain relieving constipation of dispelling, relieving rigidity of muscles and joints, control contracture, paralysis, the card such as dry, puckery。Nutrient QI being deficient and exterior syndrome being not relieved person, assistant, with agent such as bavin, Pueraria lobota, fiber crops, osmanthus, can dissipate greatly Biao Weire, and person do not held back by table, help with Radix Et Rhizoma Rhei etc, again can consolidating superficial resistance。Precisely because gas Xin Erdong, therefore it is intended to its quiet person when keeping away it, the sliding benefaction of property, stool does not consolidate person when keeping away it。All cloudy moderate heat Sheng persons, the active blood of Radix Angelicae Sinensis, also non-institute is suitable, and cloudy deficiency of YANG of middle-JIAO person, Radix Angelicae Sinensis can nourish blood, and is indispensable。

Rhizoma Chuanxiong, pungent, temperature。Enter liver, gallbladder meridian。Activating QI to alleviate the depression, method wind-dryness is wet, promoting blood circulation and stopping pain。Controlling air-cooled headache rotation dizzy, hypochondriac pain abdomen aches, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation block pain, ulcer sores。For menoxenia, amenorrhea dysmenorrhea, abdominal mass is suffered from abdominal pain, breast side of body twinge, tumbling and swelling, headache, rheumatic arthralgia。" herbal classic " carries it: main apoplexy enters brain headache, arthralgia due to cold, clonic spasm of the muscle emergency, and gold wound, married woman's blood closes loss of fecundity。" not Lu " carries it: " except cold dynamic in brain, on face, urticaria goes, order lacrimation, profuse nasal discharge and spittle, before we notice it as liquor-saturated, all cold gas, trusted subordinate's heavily fortified point pain, attacked by pestiferous factors, soldier is anxious to swell and ache, side of body wind bitterly, warming middle-JIAO endogenous cold。" it is the good medicine of regulating qi to disperse stagnation。

Pericarpium Citri Reticulatae is warm in nature, acrid in the mouth, bitter in the mouth。Enter spleen channel, stomach warp, lung meridian。Regulating qi-flowing for strengthening spleen, in tune, dampness, reduce phlegm。Cure mainly distension and fullness in the abdomen or pain, the dyspepsia of stagnation of QI in spleen and stomach。Abdominal distention uncomfortable in chest in turbid damp resistance, indigestion and loss of appetite loose stool。Phlegm-damp stops up the cough and asthma of lung。For fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm。Compendium of Material Medica: it is to hundred and always takes chess and regulates the flow of vital energy the merit of dampness, then mends with tonic, then rushes down with cathartic, then rise with Hydrargyri Oxydum Rubrum, then drops with dropping medicine。Spleen is the mother of vigour, lung be take the photograph gas want, therefore Pericarpium Citri tangerinae be two through edema caused by disorder of QI want, but with join and reinforcing and reducing lift also。" daily book on Chinese herbal medicine ": can dissipate and can rush down, can temperature can mend, and can disappear diaphragm gas, and reduce phlegm saliva, and spleen antitussive, logical five types of stranguria。

The micro-hardship of Rhizoma Polygoni Cuspidati, it is slightly cold。Return liver, gallbladder, lung meridian。There is the function of heat-clearing and toxic substances removing, promoting the function of the gallbladder to alleviate jaundice, expelling wind and removing dampness, dissipating blood stasis analgesic therapy, relieving cough and resolving phlegm。Cure mainly arthralgia, jaundice due to damp-heat, amenorrhea, abdominal mass, cough with copious phlegm, burn due to hot liquid or fire, injury from falling down, carbuncle sore tumefacting virus。Anemia of pregnant woman is cautious use of。

Pheretima: salty in the mouth is cold in nature, returns liver, spleen, bladder warp, clearing away heat and relieving the wind syndrome, dredging collateral, diuresis of relievining asthma。Modern pharmacological research Pheretima has the effects such as analgesia, convulsion, antipyretic, blood pressure lowering, antithrombotic, antitumor。

Herba Portulacae inducing diuresis to remove edema, reduces blood pressure。Herba Portulacae contains substantial amounts of potassium salt, has good inducing diuresis to remove edema effect；Potassium ion also can be done directly in blood vessel wall, makes blood vessel wall expand, and stops ductus arteriosus wall to thicken, thus playing the effect reduced blood pressure。Medicinal function is heat-clearing and toxic substances removing, cooling blood for hemostasis。Because it contains abundant norepinephrine, pancreas islet gland excreting insulin can be promoted, regulate human body carbohydrate metabolism process, reduce blood sugar concentration, keep blood glucose constant, so diabetes have certain therapeutical effect。In addition it contains a kind of unsaturated fatty acid being called 3 W, the generation of cholesterol and triglyceride can be suppressed, cardiovascular is had protective effect。Compendium of Material Medica: " dissipate blood detumescence, profit intestinal habitual abortion, detoxify treating stranguria, sweating due to debility after managing property。"

Folium Ginkgo: function cures mainly: relieving asthma, blood circulation promoting and blood stasis dispelling, pain relieving, for cough and asthma due to lung deficiency, coronary heart diseases and angina pectoris, hyperlipidemia。

Radix Puerariae, sweet in the mouth, pungent, cool in nature。Enter spleen, stomach warp。There is yang invigorating expelling pathogenic factors from muscles, rash antidiarrheal, effect of relieving restlessness only temperature。For typhoid fever, warm headache stiffness of the nape, dysphoria with smothery sensation is quenched one's thirst, and has loose bowels, dysentery, and skin eruption is not saturating, hypertension, and angina pectoris is deaf。It is used for Hypertension neck pain, angina pectoris clinically, but also there is hypoglycemic activity。

Semen Cassiae is the mature seed of leguminous plant Semen Cassiae, is also known as Semen Cassiae。Shennong's Herbal is recorded Semen Cassiae sweetness and bitterness and is slightly cold, and returns liver, gallbladder, kidney three warp, has liver heat removing and eyesight improving, loosening bowel to relieve constipation, the function of lipid-lowering weight-reducing, can be used for dizziness of having a headache, and conjunctival congestion is dim-sighted, constipation etc., in recent years clinically again for the treatment of hypertension。Semen Cassiae, containing anthraglycosides material, produces rheum emodin, physcione, chrysophanic acid, chrysophanol and glucose etc. after decomposition。It is demonstrated experimentally that Semen Cassiae has blood pressure lowering, blood fat reducing, the effect such as antibacterial, being used for treating hyperlipemia has certain curative effect。Except medicinal ingredient, Semen Cassiae is possibly together with multivitamin and abundant aminoacid, carbohydrate etc.。

Fructus Crataegi: property, tepor。Taste is sweet, sour。Enter spleen, stomach, Liver Channel。This product is apt to promoting QI to circulate and dispersing the agglomeration of the pathogens, the effect of promoting digestion and removing stagnation；Current QI and blood, blood circulation promoting and blood stasis dispelling, treatment hyperlipidemia, hypertension all have good therapeutic effect；Its energy blood fat reducing, atherosclerosis, can reduce again serum cholesterol and triglyceride；Can also coronary artery dilator, increase coronary flow, Ischemic myocardium anoxia, heart tonifying, blood pressure lowering and arrhythmia；Removing Blood Stasis and do not hinder fresh blood, dissipating depression of QI gas and do not hinder healthy energy, its property peace especially is also。

Rhizoma Gastrodiae: property is flat。Taste, sweet。Master enters Liver Channel。This product endogenous wind stopping relieving convulsion, suppressing liver-YANG, dispelling wind and removing obstruction in the collateral。For controlling the key medicine of dizziness, headache；Again in numb limbs and tense tendons, hands and feet caused by paralysis, rheumatic arthralgia, the good merchantable brand of muscles and bones contracture。

Theory of Chinese medical science is thought, " three high " disease disease mainly by the imbalance of YIN and YANG of the heart, Liver and kidney function, adds that exopathogen such as experiencing wind, heat, poison is attacked, and the expectorant in human body, the mutual knot of the stasis of blood, and caused by various factors interacts。Therefore, by suppressing the hyperactive liver and subsiding YANG, vital energy regualting and blood circulation-promoting, YIN nourishing supports kidney, and Qingre Quyu is the effective way that treatment " three high " disease is sick。Desirable medicine should be to reverse its pathological process vessel softening while, prevents and treats the generation of complication, and should without obvious toxic and side effects。The present invention is based on above-mentioned theory, collects multiple Chinese herbal medicine and develops。Its present invention can quick blood circulation promoting and blood stasis dispelling, dredge the meridian passage, for hyperlipidemia, drop that blood is viscous, vessel softening, adjustment blood fat, for treating and preventing " three high ", there is unique curative effect。

The pharmaceutical composition compatibility of the vessel softening of the present invention meets Chinese medicine " monarch " principle, gives prominence to the key points, comprehensive and reasonable, by oral drugs scalable function, reduce blood fat, vessel softening, make blood matter rare clearly, increase blood flowing vigor, softening vessel effect is obvious, and abundant raw materials, preparation technology is simple, has no side effect, price is low, has good application prospect in vessel softening, treatment and prevention " three high " especially hyperlipidemia。

Detailed description of the invention

For making the purpose of the embodiment of the present invention, technical scheme and advantage clearly, below in conjunction with embodiment, technical scheme is clearly and completely described。Obviously, described embodiment is the part of the present invention, rather than whole embodiments。Based on described embodiments of the invention, the every other embodiment that those of ordinary skill in the art obtain under the premise without creative work, broadly fall into the scope of protection of the invention。Except as otherwise noted, the percent of the amount of alcohol in the present invention is percentage by volume, and v/v represents the volume ratio of solution。

Embodiment 1:

The pharmaceutical composition of a kind of vessel softening of the present invention, takes following traditional Chinese medicine raw medicine: 12 grams of crataegus pin natifida var. Major leaf, Scorpio 16 grams, Radix Angelicae Sinensis 3 grams, Squama Manis 12 grams, Radix Achyranthis Bidentatae 12 grams, Radix Salviae Miltiorrhizae 10 grams, 9 grams of Flos Carthami, the Rhizoma Atractylodis Macrocephalae 15 grams, Fructus Atriplicis Sibiricae 15 grams, Herba Artemisiae Scopariae 8 grams, Cortex Mori 5 grams, Rhizoma Et Radix Notopterygii 3 grams, Caulis Spatholobi 14 grams, Ramulus Uncariae Cum Uncis 9 grams, Rhizoma Chuanxiong 6 grams, Folium Crossostephii Chinensis 8 grams, Herba Saussureae Involueratae 5 grams, Folium Eucommiae 1 gram, Pericarpium Citri Reticulatae 10 grams, Radix Notoginseng 5 grams, Rhizoma Polygoni Cuspidati 16 grams, Pheretima 10 grams, Herba Portulacae 8 grams, Folium Ginkgo 5 grams, 1 gram of Poria, Radix Puerariae 10 grams, Semen Cassiae 6 grams, Fructus Crataegi 8 grams, 3 grams of Rhizoma Gastrodiae。

Embodiment 2:

The pharmaceutical composition of a kind of vessel softening of the present invention, takes following traditional Chinese medicine raw medicine: 20 grams of crataegus pin natifida var. Major leaf, Scorpio 10 grams, Radix Angelicae Sinensis 8 grams, Squama Manis 5 grams, Radix Achyranthis Bidentatae 17 grams, Radix Salviae Miltiorrhizae 12 grams, 4 grams of Flos Carthami, the Rhizoma Atractylodis Macrocephalae 20 grams, Fructus Atriplicis Sibiricae 10 grams, Herba Artemisiae Scopariae 12 grams, Cortex Mori 2 grams, Rhizoma Et Radix Notopterygii 7 grams, Caulis Spatholobi 11 grams, Ramulus Uncariae Cum Uncis 15 grams, Rhizoma Chuanxiong 3 grams, Folium Crossostephii Chinensis 13 grams, Herba Saussureae Involueratae 3 grams, Folium Eucommiae 3 grams, Pericarpium Citri Reticulatae 5 grams, Radix Notoginseng 10 grams, Rhizoma Polygoni Cuspidati 13 grams, Pheretima 3 grams, Herba Portulacae 13 grams, Folium Ginkgo 3 grams, 3 grams of Poria, Radix Puerariae 5 grams, Semen Cassiae 4 grams, Fructus Crataegi 10 grams, 4 grams of Rhizoma Gastrodiae。

Embodiment 3:

The pharmaceutical composition of a kind of vessel softening of the present invention, takes following traditional Chinese medicine raw medicine: 13 grams of crataegus pin natifida var. Major leaf, Scorpio 11 grams, Radix Angelicae Sinensis 4 grams, Squama Manis 6 grams, Radix Achyranthis Bidentatae 13 grams, Radix Salviae Miltiorrhizae 7 grams, 5 grams of Flos Carthami, the Rhizoma Atractylodis Macrocephalae 18 grams, Fructus Atriplicis Sibiricae 11 grams, Herba Artemisiae Scopariae 9 grams, Cortex Mori 4 grams, Rhizoma Et Radix Notopterygii 6 grams, Caulis Spatholobi 12 grams, Ramulus Uncariae Cum Uncis 13 grams, Rhizoma Chuanxiong 4 grams, Folium Crossostephii Chinensis 9 grams, Herba Saussureae Involueratae 4 grams, Folium Eucommiae 2 grams, Pericarpium Citri Reticulatae 6 grams, Radix Notoginseng 6 grams, Rhizoma Polygoni Cuspidati 14 grams, Pheretima 5 grams, Herba Portulacae 10 grams, Folium Ginkgo 4 grams, 2 grams of Poria, Radix Puerariae 6 grams, Semen Cassiae 5 grams, Fructus Crataegi 12 grams, 3 grams of Rhizoma Gastrodiae。

Embodiment 4:

The pharmaceutical composition of a kind of vessel softening of the present invention, takes following traditional Chinese medicine raw medicine: 17 grams of crataegus pin natifida var. Major leaf, Scorpio 15 grams, Radix Angelicae Sinensis 7 grams, Squama Manis 11 grams, Radix Achyranthis Bidentatae 16 grams, Radix Salviae Miltiorrhizae 8 grams, 8 grams of Flos Carthami, the Rhizoma Atractylodis Macrocephalae 16 grams, Fructus Atriplicis Sibiricae 14 grams, Herba Artemisiae Scopariae 11 grams, Cortex Mori 3 grams, Rhizoma Et Radix Notopterygii 5 grams, Caulis Spatholobi 13 grams, Ramulus Uncariae Cum Uncis 14 grams, Rhizoma Chuanxiong 5 grams, Folium Crossostephii Chinensis 12 grams, Herba Saussureae Involueratae 3 grams, Folium Eucommiae 1 gram, Pericarpium Citri Reticulatae 10 grams, Radix Notoginseng 9 grams, Rhizoma Polygoni Cuspidati 13 grams, Pheretima 7 grams, Herba Portulacae 11 grams, Folium Ginkgo 3 grams, 1 gram of Poria, Radix Puerariae 10 grams, Semen Cassiae 4 grams, Fructus Crataegi 11 grams, 4 grams of Rhizoma Gastrodiae。

Embodiment 5:

The pharmaceutical composition of a kind of vessel softening of the present invention, takes following traditional Chinese medicine raw medicine: 15 grams of crataegus pin natifida var. Major leaf, Scorpio 12 grams, Radix Angelicae Sinensis 5 grams, Squama Manis 9 grams, Radix Achyranthis Bidentatae 15 grams, Radix Salviae Miltiorrhizae 9 grams, 7 grams of Flos Carthami, the Rhizoma Atractylodis Macrocephalae 19 grams, Fructus Atriplicis Sibiricae 13 grams, Herba Artemisiae Scopariae 10 grams, Cortex Mori 4 grams, Rhizoma Et Radix Notopterygii 4 grams, Caulis Spatholobi 11 grams, Ramulus Uncariae Cum Uncis 11 grams, Rhizoma Chuanxiong 5 grams, Folium Crossostephii Chinensis 10 grams, Herba Saussureae Involueratae 5 grams, Folium Eucommiae 3 grams, Pericarpium Citri Reticulatae 8 grams, Radix Notoginseng 8 grams, Rhizoma Polygoni Cuspidati 14 grams, Pheretima 9 grams, Herba Portulacae 12 grams, Folium Ginkgo 5 grams, 3 grams of Poria, Radix Puerariae 8 grams, Semen Cassiae 6 grams, Fructus Crataegi 9 grams, 5 grams of Rhizoma Gastrodiae。

Embodiment 6:

The pharmaceutical composition of a kind of vessel softening of the present invention, takes following traditional Chinese medicine raw medicine: 19 grams of crataegus pin natifida var. Major leaf, Scorpio 14 grams, Radix Angelicae Sinensis 6 grams, Squama Manis 7 grams, Radix Achyranthis Bidentatae 14 grams, Radix Salviae Miltiorrhizae 9 grams, 6 grams of Flos Carthami, the Rhizoma Atractylodis Macrocephalae 17 grams, Fructus Atriplicis Sibiricae 13 grams, Herba Artemisiae Scopariae 10 grams, Cortex Mori 4 grams, Rhizoma Et Radix Notopterygii 4 grams, Caulis Spatholobi 11 grams, Ramulus Uncariae Cum Uncis 11 grams, Rhizoma Chuanxiong 5 grams, Folium Crossostephii Chinensis 10 grams, Herba Saussureae Involueratae 5 grams, Folium Eucommiae 3 grams, Pericarpium Citri Reticulatae 8 grams, Radix Notoginseng 8 grams, Rhizoma Polygoni Cuspidati 14 grams, Pheretima 4 grams, Herba Portulacae 9 grams, Folium Ginkgo 5 grams, 3 grams of Poria, Radix Puerariae 8 grams, Semen Cassiae 3 grams, Fructus Crataegi 8 grams, 5 grams of Rhizoma Gastrodiae。

Wherein, the preparation method of the described Chinese medicine composition of embodiment 1-6 is:

(1) each medical material of components by weight percent in the arbitrary described Chinese medicine composition of Example 1-6, add in the ethanol of 5-10 times amount and soak 1-2 hour, heating extraction 2 times, each 1-2 hour, removes supernatant, united extraction liquid, 100-120 order filters, the ultrafiltration post ultrafiltration that molecular weight is 5000-10000 then through damming, the extractum of 1.36 when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C, heating is concentrated into paste, stand for standby use；

(2) being put in 10 times amount water by the medicinal residues that ethanol extraction is crossed, be then placed in extraction pot heated and boiled 1 hour, filter, filtrate is standby；Filtering residue adds water, second time heating, boils 45 minutes, filters, and filtrate is standby；

(3) 2 filtrates in step (2) being combined, by filtered through gauze, add 50-60% ethanol in residue, 60 DEG C-70 DEG C are continued lixiviate 2h, every 10min and stir once, and filtered through gauze merges lixiviating solution, is condensed into pasty state；

(4) the pastel decompression recycling ethanol that step (1) paste that obtains of concentration and step (3) obtained to be concentrated into liquor strength be 0.6-0.7g crude drug/mL, after sucking filtration, the relative density of filtrate is about 1.0-1.1 when 20 DEG C；It is centrifuged under the rotating speed of 3000r/min；At 60 DEG C of-80 DEG C of spray drying, obtain dry extract；

(5) dry extract that step (4) prepares is pulverized, add suitable amount of sucrose, dextrin mixing, with ethanol for wetting agent, granulate, dry, granulate, granule can be prepared；Or the dry extract that step (4) prepares be dry, pulverize, make powder；Or dry extract step (4) prepared is pulverized, add appropriate micropowder silica gel, α-galactose mixing, with ethanol for wetting agent, granulate, dry, granulate, encapsulated, prepare capsule；Or dry extract step (4) prepared is pulverized, add suitable amount of sucrose, dextrin mixing, with ethanol for wetting agent, granulate, dry, granulate, tabletting, prepare tablet；Or to above-mentioned steps (4) obtain centrifugal after concentrated solution in add suitable amount of sucrose, essence mixing, sterilizing, fill, prepare medicinal liquid agent。

Acute toxicity test

Method one:

Test material: Kunming mouse 40, body weight 22-25g。Medicine: the medicinal liquid agent that the embodiment of the present invention 3 prepares, containing 0.0365mg/ml。

Method:

LD50 calculates: adopt improvement karber's method, mice is randomly divided into 4 groups, often group 10, the medicinal liquid agent that the embodiment of the present invention 3 prepares is added distilled water dissolve, be made into Cmax, by the maximum allowable capacity administration of mice, institute is followed successively by 18,14.4,11.5 to dosage by crude drug amount, 9.2,7.4 (g.kg-1), after animal fasting (can't help water) 18 hours, administration (interval half an hour) at twice in a day, each 0.5ml, observes animal dead situation。

Result of the test: in LD50 calculates when giving mice with maximum acceptable concentration and maximum allowable capacity (18g/Kg.d), have no dead mouse, namely LD50 is not measured, seeking maximum tolerated dose only, to observation post administration 14 days, none was dead for mice, main organs no abnormality seen, also have no other substantially abnormal, within the 14th day, put to death and cut open inspection some animals, perusal main organs no abnormality seen。Namely select the 300 times of doses being equivalent to clinical dosage, and have no adverse reaction, it was shown that acute toxicity is minimum, MTD > 18g/Kg.d。

Six months long term toxicity tests: weigh weekly once during administration, claim appetite every day, and without dead or moribund animals, result mice hair color is bright and clean, and behavioral activity, glandular secretion, breathing, feces character are all normal。Pathologic finding is pointed out, to various internal organs without obvious drug-induced pathological change。

Clinical reasoning:

In order to verify the effect of pharmaceutical composition of the present invention, in May ,-2014 in October, 2012, hyperlipemic patients 180 example is randomly drawed in outpatient service place, year at age 45～68 (55 ± 10.41), male patient 88 example, female patient 92 example。In hyperlipidemia medical history 3～16 (8.92 ± 3.21) year, body weight, height, motion, diet etc. do not have notable difference, P > 0.05, wherein 1 phase hyperpietic 90 example, 2 phase phase hyperpietic 65 examples, 3 phase hyperpietic 25 examples。It is randomly divided into treatment group and each 90 examples of matched group。

Electrocardiogram and lab testing:

Equal routine examination blood pressure (BP), electrocardiogram (ECG), glycolated hemoglobin (Hbaic%), triglyceride (TG), low density lipoprotein, LDL (LDLC), high density lipoprotein fHDL after being admitted to hospital) etc.。

Treatment

Matched group carries out conventional therapy, adopts the routine medication such as XINKESHU PIAN, JIANGZHILINGPIAN, actively moves。

Treatment group uses the tablet of embodiment 3 to treat, each two panels, every day 2-3 time, 10 days courses for the treatment of, continuously 2-4 the course for the treatment of of treatment, does not increase the Therapeutic Method of other traditional Chinese medical science or doctor trained in Western medicine。

Curative effect determinate standard

Cure: symptom all disappears；Main Physico-chemical tests index is normally。

Effective: symptomatology eliminates or cardinal symptom eliminates；Physico-chemical tests index is normal。

Effective: cardinal symptom disappears substantially；Main Physico-chemical tests index makes moderate progress。

Invalid: main Physico-chemical tests index is front with treatment unchanged。

Result:

Curative effect comparision result such as following table after two groups of case treatments:

Two groups of patient clinical comparitive study (example %)

Group	Number of cases	Cure	Effective	Effectively	Invalid	Total effective
							Treatment group	90	27 (30%)	54 (60%)	6 (6.7%)	3 (3.3%)	87 (96.7%)
Matched group	90	4 (4.4%)	27 (30%)	11 (12.2%)	48 (53.3%)	42 (46.7%)

Two groups of patient clinical comparitive study: treatment group total effective rate is 96.7%, matched group is 46.7%, two groups of comparing differences statistically significant (P < 0.05)。Treatment group is better than matched group。Visible, medicine that the preferred embodiment for the present invention prepares can safe and effective vessel softening, effective percentage is significantly higher than matched group。

Last it is noted that above example is only in order to illustrate technical scheme, it is not intended to limit；Although the present invention being described in detail with reference to previous embodiment, it will be understood by those within the art that: the technical scheme described in foregoing embodiments still can be modified by it, or wherein portion of techniques feature is carried out equivalent replacement；And these amendments or replacement, do not make the essence of appropriate technical solution depart from the scope of various embodiments of the present invention technical scheme。

Claims (10)

1. the pharmaceutical composition of a vessel softening, it is characterised in that: the crude drug of described pharmaceutical composition is made up of crataegus pin natifida var. Major leaf, Radix Salviae Miltiorrhizae, Scorpio, Squama Manis, Radix Achyranthis Bidentatae, Rhizoma Et Radix Notopterygii, the Rhizoma Atractylodis Macrocephalae, Fructus Atriplicis Sibiricae, Radix Notoginseng, Herba Artemisiae Scopariae, Cortex Mori, Caulis Spatholobi, Ramulus Uncariae Cum Uncis, Flos Carthami, Folium Crossostephii Chinensis, Poria, Herba Saussureae Involueratae, Folium Eucommiae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Pericarpium Citri Reticulatae, Rhizoma Polygoni Cuspidati, Pheretima, Herba Portulacae, Folium Ginkgo, Radix Puerariae, Semen Cassiae, Fructus Crataegi, Rhizoma Gastrodiae。

2. the pharmaceutical composition of vessel softening according to claim 1, it is characterized in that: make described pharmaceutical composition raw material composition and parts by weight be: crataegus pin natifida var. Major leaf 12-20 part, Scorpio 10-16 part, Radix Angelicae Sinensis 3-8 part, Squama Manis 5-12 part, Radix Achyranthis Bidentatae 12-17 part, Radix Salviae Miltiorrhizae 7-12 part, Flos Carthami 4-9 part, Rhizoma Atractylodis Macrocephalae 15-20 part, Fructus Atriplicis Sibiricae 10-15 part, Herba Artemisiae Scopariae 8-12 part, Cortex Mori 2-5 part, Rhizoma Et Radix Notopterygii 3-7 part, Caulis Spatholobi 11-14 part, Ramulus Uncariae Cum Uncis 9-15 part, Rhizoma Chuanxiong 3-6 part, Folium Crossostephii Chinensis 8-13 part, Herba Saussureae Involueratae 3-5 part, Folium Eucommiae 1-3 part, Pericarpium Citri Reticulatae 5-10 part, Radix Notoginseng 5-10 part, Rhizoma Polygoni Cuspidati 13-16 part, Pheretima 3-10 part, Herba Portulacae 8-13 part, Folium Ginkgo 3-5 part, Poria 1-3 part, Radix Puerariae 5-10 part, Semen Cassiae 3-6 part, Fructus Crataegi 8-13 part, Rhizoma Gastrodiae 3-5 part。

3. the pharmaceutical composition of vessel softening according to claim 1, it is characterized in that: make described pharmaceutical composition raw material composition and parts by weight be: 12 parts of crataegus pin natifida var. Major leaf, Scorpio 16 parts, Radix Angelicae Sinensis 3 parts, Squama Manis 12 parts, Radix Achyranthis Bidentatae 12 parts, Radix Salviae Miltiorrhizae 10 parts, 9 parts of Flos Carthami, the Rhizoma Atractylodis Macrocephalae 15 parts, Fructus Atriplicis Sibiricae 15 parts, Herba Artemisiae Scopariae 8 parts, Cortex Mori 5 parts, Rhizoma Et Radix Notopterygii 3 parts, Caulis Spatholobi 14 parts, Ramulus Uncariae Cum Uncis 9 parts, Rhizoma Chuanxiong 6 parts, Folium Crossostephii Chinensis 8 parts, Herba Saussureae Involueratae 5 parts, Folium Eucommiae 1 part, Pericarpium Citri Reticulatae 10 parts, Radix Notoginseng 5 parts, Rhizoma Polygoni Cuspidati 16 parts, Pheretima 10 parts, Herba Portulacae 8 parts, Folium Ginkgo 5 parts, 1 part of Poria, Radix Puerariae 10 parts, Semen Cassiae 6 parts, Fructus Crataegi 8 parts, 3 parts of Rhizoma Gastrodiae。

4. the pharmaceutical composition of vessel softening according to claim 1, it is characterized in that: make described pharmaceutical composition raw material composition and parts by weight be: 20 parts of crataegus pin natifida var. Major leaf, Scorpio 10 parts, Radix Angelicae Sinensis 8 parts, Squama Manis 5 parts, Radix Achyranthis Bidentatae 17 parts, Radix Salviae Miltiorrhizae 12 parts, 4 parts of Flos Carthami, the Rhizoma Atractylodis Macrocephalae 20 parts, Fructus Atriplicis Sibiricae 10 parts, Herba Artemisiae Scopariae 12 parts, Cortex Mori 2 parts, Rhizoma Et Radix Notopterygii 7 parts, Caulis Spatholobi 11 parts, Ramulus Uncariae Cum Uncis 15 parts, Rhizoma Chuanxiong 3 parts, Folium Crossostephii Chinensis 13 parts, Herba Saussureae Involueratae 3 parts, Folium Eucommiae 3 parts, Pericarpium Citri Reticulatae 5 parts, Radix Notoginseng 10 parts, Rhizoma Polygoni Cuspidati 13 parts, Pheretima 3 parts, Herba Portulacae 13 parts, Folium Ginkgo 3 parts, 3 parts of Poria, Radix Puerariae 5 parts, Semen Cassiae 4 parts, Fructus Crataegi 10 parts, 4 parts of Rhizoma Gastrodiae。

5. the pharmaceutical composition of vessel softening according to claim 1, it is characterized in that: make described pharmaceutical composition raw material composition and parts by weight be: 13 parts of crataegus pin natifida var. Major leaf, Scorpio 11 parts, Radix Angelicae Sinensis 4 parts, Squama Manis 6 parts, Radix Achyranthis Bidentatae 13 parts, Radix Salviae Miltiorrhizae 7 parts, 5 parts of Flos Carthami, the Rhizoma Atractylodis Macrocephalae 18 parts, Fructus Atriplicis Sibiricae 11 parts, Herba Artemisiae Scopariae 9 parts, Cortex Mori 4 parts, Rhizoma Et Radix Notopterygii 6 parts, Caulis Spatholobi 12 parts, Ramulus Uncariae Cum Uncis 13 parts, Rhizoma Chuanxiong 4 parts, Folium Crossostephii Chinensis 9 parts, Herba Saussureae Involueratae 4 parts, Folium Eucommiae 2 parts, Pericarpium Citri Reticulatae 6 parts, Radix Notoginseng 6 parts, Rhizoma Polygoni Cuspidati 14 parts, Pheretima 5 parts, Herba Portulacae 10 parts, Folium Ginkgo 4 parts, 2 parts of Poria, Radix Puerariae 6 parts, Semen Cassiae 5 parts, Fructus Crataegi 12 parts, 3 parts of Rhizoma Gastrodiae。

6. the pharmaceutical composition of vessel softening according to claim 1, it is characterized in that: make described pharmaceutical composition raw material composition and parts by weight be: 17 parts of crataegus pin natifida var. Major leaf, Scorpio 15 parts, Radix Angelicae Sinensis 7 parts, Squama Manis 11 parts, Radix Achyranthis Bidentatae 16 parts, Radix Salviae Miltiorrhizae 8 parts, 8 parts of Flos Carthami, the Rhizoma Atractylodis Macrocephalae 16 parts, Fructus Atriplicis Sibiricae 14 parts, Herba Artemisiae Scopariae 11 parts, Cortex Mori 3 parts, Rhizoma Et Radix Notopterygii 5 parts, Caulis Spatholobi 13 parts, Ramulus Uncariae Cum Uncis 14 parts, Rhizoma Chuanxiong 5 parts, Folium Crossostephii Chinensis 12 parts, Herba Saussureae Involueratae 3 parts, Folium Eucommiae 1 part, Pericarpium Citri Reticulatae 10 parts, Radix Notoginseng 9 parts, Rhizoma Polygoni Cuspidati 13 parts, Pheretima 7 parts, Herba Portulacae 11 parts, Folium Ginkgo 3 parts, 1 part of Poria, Radix Puerariae 10 parts, Semen Cassiae 4 parts, Fructus Crataegi 11 parts, 4 parts of Rhizoma Gastrodiae。

7. the pharmaceutical composition of vessel softening according to claim 1, it is characterized in that: make described pharmaceutical composition raw material composition and parts by weight be: 15 parts of crataegus pin natifida var. Major leaf, Scorpio 12 parts, Radix Angelicae Sinensis 5 parts, Squama Manis 9 parts, Radix Achyranthis Bidentatae 15 parts, Radix Salviae Miltiorrhizae 9 parts, 7 parts of Flos Carthami, the Rhizoma Atractylodis Macrocephalae 19 parts, Fructus Atriplicis Sibiricae 13 parts, Herba Artemisiae Scopariae 10 parts, Cortex Mori 4 parts, Rhizoma Et Radix Notopterygii 4 parts, Caulis Spatholobi 11 parts, Ramulus Uncariae Cum Uncis 11 parts, Rhizoma Chuanxiong 5 parts, Folium Crossostephii Chinensis 10 parts, Herba Saussureae Involueratae 5 parts, Folium Eucommiae 3 parts, Pericarpium Citri Reticulatae 8 parts, Radix Notoginseng 8 parts, Rhizoma Polygoni Cuspidati 14 parts, Pheretima 9 parts, Herba Portulacae 12 parts, Folium Ginkgo 5 parts, 3 parts of Poria, Radix Puerariae 8 parts, Semen Cassiae 6 parts, Fructus Crataegi 9 parts, 5 parts of Rhizoma Gastrodiae。

8. the pharmaceutical composition of vessel softening according to claim 1, it is characterized in that: make described pharmaceutical composition raw material composition and parts by weight be: 19 parts of crataegus pin natifida var. Major leaf, Scorpio 14 parts, Radix Angelicae Sinensis 6 parts, Squama Manis 7 parts, Radix Achyranthis Bidentatae 14 parts, Radix Salviae Miltiorrhizae 9 parts, 6 parts of Flos Carthami, the Rhizoma Atractylodis Macrocephalae 17 parts, Fructus Atriplicis Sibiricae 13 parts, Herba Artemisiae Scopariae 10 parts, Cortex Mori 4 parts, Rhizoma Et Radix Notopterygii 4 parts, Caulis Spatholobi 11 parts, Ramulus Uncariae Cum Uncis 11 parts, Rhizoma Chuanxiong 5 parts, Folium Crossostephii Chinensis 10 parts, Herba Saussureae Involueratae 5 parts, Folium Eucommiae 3 parts, Pericarpium Citri Reticulatae 8 parts, Radix Notoginseng 8 parts, Rhizoma Polygoni Cuspidati 14 parts, Pheretima 4 parts, Herba Portulacae 9 parts, Folium Ginkgo 5 parts, 3 parts of Poria, Radix Puerariae 8 parts, Semen Cassiae 3 parts, Fructus Crataegi 8 parts, 5 parts of Rhizoma Gastrodiae。

9. the pharmaceutical composition according to the arbitrary described vessel softening of claim 3-8, it is characterised in that: described Chinese medicine composition is prepared in following manner:

(1) each medical material of components by weight percent in the arbitrary described pharmaceutical composition of claim 3-8 is taken, add in the ethanol of 5-10 times amount and soak 1-2 hour, heating extraction 2 times, each 1-2 hour, removes supernatant, united extraction liquid, 100-120 order filters, the ultrafiltration post ultrafiltration that molecular weight is 5000-10000 then through damming, the extractum of 1.36 when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C, heating is concentrated into paste, stand for standby use；

(2) being put in 10 times amount water by the medicinal residues that ethanol extraction is crossed, be then placed in extraction pot heated and boiled 1 hour, filter, filtrate is standby；Filtering residue adds water, second time heating, boils 45 minutes, filters, and filtrate is standby；

(3) 2 filtrates in step (2) being combined, by filtered through gauze, add 50-60% ethanol in residue, 60 DEG C-70 DEG C are continued lixiviate 2h, every 10min and stir once, and filtered through gauze merges lixiviating solution, is condensed into pasty state；

(4) the pastel decompression recycling ethanol that step (1) paste that obtains of concentration and step (3) obtained to be concentrated into liquor strength be 0.6-0.7g crude drug/mL, after sucking filtration, the relative density of filtrate is about 1.0-1.1 when 20 DEG C；It is centrifuged under the rotating speed of 3000r/min；At 60 DEG C of-80 DEG C of spray drying, obtain dry extract；

(5) dry extract that step (4) prepares is pulverized, add suitable amount of sucrose, dextrin mixing, with ethanol for wetting agent, granulate, dry, granulate, granule can be prepared；Or the dry extract that step (4) prepares be dry, pulverize, make powder；Or dry extract step (4) prepared is pulverized, add appropriate micropowder silica gel, α-galactose mixing, with ethanol for wetting agent, granulate, dry, granulate, encapsulated, prepare capsule；Or dry extract step (4) prepared is pulverized, add suitable amount of sucrose, dextrin mixing, with ethanol for wetting agent, granulate, dry, granulate, tabletting, prepare tablet；Or to above-mentioned steps (4) obtain centrifugal after concentrated solution in add suitable amount of sucrose, essence mixing, sterilizing, fill, prepare medicinal liquid agent。

10. the application in vessel softening medicine of the pharmaceutical composition of the vessel softening as described in as arbitrary in claim 1-9。