CN105476601A - Portable mechanical hyperalgesia measuring apparatus - Google Patents

Abstract

The invention relates to a portable mechanical pain sensitivity detector. The structure of the present invention is that the probe is connected to the shaft, the shaft passes through the cylinder and is connected to the recording part, and the recording part is connected to the refill, and an arc-shaped scale is arranged beside the refill; a spring is arranged inside the cylinder, and the inner bottom of the cylinder is connected There is a round tube; the probe includes a needle body and a base, the core includes a shaft, a disc, and an upper screw, the recording part includes a wire, a metal tube, and a lower screw, and the cylindrical part includes a cylinder , Arc surface scale, round tube. The invention overcomes the defects of high price, fragile probe, dependence on power supply, relatively bulky and the like. The measuring device of the present invention is simple to prepare, and probes, shafts, metal wires, cylinders, circular tubes, springs, etc. are commonly used items to measure the degree of pain sensitivity of rat limbs, with good sensitivity and simple operation. Power supply and other special conditions are more energy-saving and environmentally friendly than traditional methods.

Description

Portable Mechanical Pain Sensitivity Tester

technical field

The invention relates to the field of medical devices, in particular to a portable mechanical pain sensitivity detector.

Background technique

Pain is divided into acute pain and chronic pain. Acute pain is one of the body's protective reflexes, but chronic pain is often a morbid manifestation. Chronic pain often manifests as hyperalgesia and paresthesia at the site of injury and adjacent tissues. It has the characteristics of complex etiology and mechanism, and is difficult to relieve. Basic research on its mechanism and treatment strategies has always been a research hotspot.

Experimental chronic pain research is inseparable from the measurement of pain behavior. Since pain is a subjective feeling and animals cannot express pain perception, it often involves the measurement of mechanical hyperalgesia and thermal hyperalgesia. The mechanical hyperalgesia The measurement is most commonly used.

Before the present invention, VonFrey is currently used to monitor mechanical pain sensitivity. The principle is that the rat is placed on the iron net, the probe needle of the machine is aimed at the sole of the rat's foot, and the probe is lifted vertically upward slowly until the rat The sole of the foot is raised reflexively, and the machine displays the strength of the foot withdrawal, which is the mechanical foot withdrawal threshold. The smaller the value, the more painful it is. Although its measurement sensitivity is high, its biggest disadvantages are: 1. High price and poor availability; 2. The probe is fragile, and the probe is a delicate part, which determines the sensitivity of the machine. Once damaged, the maintenance cost is expensive ; 3. The measurement depends on the power supply; 4. Traditional instruments are relatively bulky.

Contents of the invention

The purpose of the present invention is just to overcome above-mentioned defect, develops a kind of portable mechanical pain sensitivity detector.

Technical scheme of the present invention is:

The main technical feature of the portable mechanical pain sensitivity tester is that the probe is connected to the shaft, the shaft passes through the cylinder and is connected to the recording part, the recording part is connected to the pen core, and an arcuate scale is arranged next to the pen core; inside the cylinder is a A spring, a circular tube connected to the inner bottom of the cylinder; the probe includes a needle body and a base, the core includes a shaft, a disc, and an upper screw, and the recording part includes a metal wire, a metal tube, and a lower screw, The cylindrical part includes a cylinder, an arcuate scale, and a circular tube.

Both the upper end and the lower end of the shaft rod have concave interfaces, the upper concave interface is connected to the base of the probe, and the lower concave interface is connected to the metal wire by means of screws.

The shaft is in the middle of the disk and is vertical to the disk. The shaft passes through the tube and the bottom of the cylinder sequentially inside the cylinder. After passing out, the upper screw directly below the bottom of the cylinder is used to connect the metal wire.

The disc fits in the opening at the upper end of the cylinder.

The bottom of the cylinder is closed, and an upward circular tube is vertically fixedly connected to the center of the bottom, and a section of the lower part of the core is inside the circular tube.

The metal wire is elastic and arc-shaped, the lower end points to the concave surface of the arc-shaped scale, and the lower end is connected with the metal pipe as an integral structure.

The metal tube is made of magnetic material.

The curved scale is made of magnetically conductive metal.

The arcuate scale is at the bottom of the cylinder and is integrally formed by part of the cylinder wall continuing downward.

The spring is inside the cylinder and outside the circular tube, the upper end is connected to the lower part of the disk of the core, and the lower end is connected to the inner bottom of the cylinder of the cylinder part.

The advantages and beneficial effects of the present invention are that the measuring device is simple to prepare, and the required materials are easily available. The probes, shafts, metal wires, cylinders, circular tubes, springs, etc. used are commonly used items; they can be used to measure rat limbs. The degree of pain sensitivity, the measurement result is represented by the maximum length x of the track of the pen core on the curved scale; the measurement sensitivity is good, and the turning point of slight force changes can be sensitively captured by recording the compression track in real time; the operation is simple and no special equipment is required The device does not require power supply and other special conditions, and is more energy-saving and environmentally friendly than traditional methods; it is suitable for the determination of mechanical pain thresholds for large and small animals, and is worthy of popularization and application.

Description of drawings:

Fig. 1 -- the schematic diagram of vertical section structure of the present invention.

Each label in the figure indicates the corresponding component name as follows:

Probe 1, core 2, recording part 3, cylinder part 4, spring 5, refill 6.

Among them, the probe 1 includes a needle body 1-1, a base part 1-2, the core 2 includes a shaft 2-1, a disk 2-2, and an upper screw 2-3, and the recording part 3 includes a metal wire 3-1, a metal The tube 3-2, the lower screw 3-3, and the cylinder part 4 include a cylinder 4-1, an arcuate scale 4-2, and a circular tube 4-3.

detailed description:

As shown in Figure 1:

The present invention is composed of a probe 1, a core 2, a recording part 3, a cylindrical part 4, a spring 5 and a refill 6; the needle body 1-1 is connected to the base part 1-2, and the base part 1-2 is connected to the shaft of the core 2 The upper end of 2-1, the shaft 2-1 is in the middle of the disc 2-2 of the core 2, and the upper and lower sides of the disc 2-2 are vertically connected to the shaft 2-1 of the core 2. In the non-working state, the core 2 The disk 2-2 is embedded in the opening of the upper end of the cylinder 4-1 of the cylinder part 4, and the shaft 2-1 of the core 2 is put into the cylinder 4-1 of the cylinder part 4 and passes through the cylinder 4-1 in turn. 3 and the bottom of the cylinder 4-1, the bottom of the cylinder 4-1 is closed but there is a round hole in the center, where the circular pipe 4-3 is fixedly connected upwards vertically, and the shaft 2-1 is connected from the bottom of the cylinder 4-1 Or after the end comes out, the upper screw 2-3 connects the metal wire 3-1 directly below the bottom of the cylinder 4-1, and at the bottom of the cylinder 4-1, part of the cylinder wall continues downward, forming an arcuate scale 4 -2; the upper screw 2-3 connects the metal wire 3-1 of the recording part 3, the metal wire 3-1 connects the metal tube 3-2, and the lower end of the metal tube 3-2 connects the pen core 6 by the lower screw 3-3; Inside the cylinder 4-1 of the tube part 4 and outside the circular pipe 4-3, the spring 5 is used as a stage clip, the upper end is connected to the bottom of the disc 2-2, and the lower end is connected to the bottom of the cylinder 4-1.

The base portion 1-2 is detachably connected to the upper end of the shaft 2-1, and can be used to replace probes 1 of different specifications; the upper and lower ends of the shaft 2-1 have concave interfaces, and the upper end of the concave interface The base part 1-2 of the probe 1 is connected, and the concave interface at the lower end is connected with the metal wire 3-1 through the upper screw 2-3.

The upper screw 2-3 can adjust the distance between the lower end of the metal wire 3-1 and the concave surface of the curved scale 4-2, and is used for zero calibration; the metal wire 3-1 is elastic and arc-shaped, and the lower end points to the curved surface The concave surface of the scale 4-2 is integrated with the metal tube 3-2; the direction of the metal tube 3-2 can be adjusted by shaping the metal wire 3-1 to assist zero adjustment; the metal tube 3-2 The tube 3-2 is made of magnetic material, and the arc-shaped scale 4-2 is made of magnetically conductive metal, and the two can attract each other. When the pen core 6 is inserted, the tip of the pen core 6 can automatically move on the arc-surface scale. 4-2 up for the record.

The bottom of the cylinder 4-1 is integrated with the circular tube 4-3; the shaft 2-1 is tangent to the inner surface of the circular tube 4-3, ensuring that the shaft 2-1 is inside the cylinder 4-1 The movement is always perpendicular to the bottom; the curved scale 4-2 is integrated with the cylinder 4-1; the concave surface of the curved scale 4-2 is marked with a scale, which is used to mark the scale on the curved surface of the refill 6 The track length left on the ruler; there is a groove on the vertical center line of the curved scale 4-2, and the pen core 6 slides therein to ensure that the pen core 6 slides in the vertical direction all the time, which is convenient for the curved scale 4-2. 2 Measure the length of the straight handwriting.

Description of the application process of the present invention:

Example 1:

Direct Mode (Taking Rats as an Example)

(1) By debugging the screw 3-3, the refill 6 can be aligned with the zero scale of the curved scale 4-2 for zero calibration;

(2) Hold the cylinder 4-1 in hand, point the probe 1 vertically upward at the sole of the rat's foot, and slowly lift the sole of the foot. If the rat does not feel pain at this time, it will not lift the foot. At this time, the cylinder The spring 5 in 4-1 will always be compressed as a compression spring, because the disc 2-2 is fixed on the upper end of the spring 5, and correspondingly its downstream integrated parts such as the recording part will have a relative displacement with the cylinder 4-1, as shown in the figure, due to There is magnetic attraction between the metal tube 3-2 and the curved scale 4-2, so the pen core 6 fixed in the metal tube 3-2 will leave a track when sliding down on the curved scale 4-2 , and because the refill always slides in the groove on the concave centerline of the curved scale 4-2, the trajectory left is a straight line;

(3) When the rat feels pain, the sole of the foot is lifted, and the pressure on the upper end of the probe 1 disappears immediately, the spring 5 recovers its deformation, and the corresponding pen core 6 slides in the opposite direction (upward), and the turning point of this track is recorded The maximum deformation of the spring 5 is shown, which reflects the pain threshold, and the pain threshold of different rats can be qualitatively compared by comparing the reentry position;

Example 2:

Indirect mode (take rats as an example)

(1) After adjusting the screw 3-3 to complete the zero calibration, insert a heavy object with a predetermined weight (such as 30g) on the probe 1, record the track length s, and obtain the elastic coefficient k=mg/s of the spring 5 through calculation;

Before the determination, the rats to be tested were weighed, and the mass was m;

(2) Adjust the screw 3-3 to complete the zero calibration again;

(3) Hold the cylinder 4-1 in hand, point the probe 1 vertically upward at the sole of the rat's foot, and slowly lift the sole of the foot. If the rat does not feel pain at this time, it will not lift the foot. At this time, the cylinder The spring 5 in 4-1 will always be compressed as a compression spring, because the disc 2-2 is fixed on the upper end of the spring 5, and correspondingly its downstream integrated parts such as the recording part will have a relative displacement with the cylinder 4-1, as shown in the figure, due to There is magnetic attraction between the metal tube 3-2 and the curved scale 4-2, so the pen core 6 fixed in the metal tube 3-2 will leave a track when sliding down on the curved scale 4-2 , and because the refill always slides in the groove on the concave centerline of the curved scale 4-2, the trajectory left is a straight line;

(4) When the rat feels pain, the sole of the foot is lifted, and the pressure on the upper end of the probe 1 disappears immediately, the spring 5 recovers its deformation, and the corresponding pen core 6 slides in the opposite direction (upward). The turning point of this track is recorded as x1 _;

(5) The pain sensitivity threshold (stimulation intensity) F ₁ =kx ₁ can be calculated according to x ₁ , and a quantitative comparison is made for all the rats tested.

To sum up, the method of the present invention is simple, which is beneficial to reduce the cost of pain mechanical pain threshold measurement, not only saves the expenditure of scientific research funds, but also saves energy and environmental protection, and promotes the further development of pain research in the long run, which is in line with innovation-driven The needs of formula basic and clinical research development.

Claims (10)

1. The portable mechanical pain sensitivity tester is characterized in that the probe is connected to the shaft, the shaft passes through the cylinder and is connected to the recording part, the recording part is connected to the pen core, and an arcuate scale is arranged next to the pen core; A spring, a circular tube connected to the inner bottom of the cylinder; the probe includes a needle body and a base, the core includes a shaft, a disc, and an upper screw, and the recording part includes a metal wire, a metal tube, and a lower screw, The cylindrical part includes a cylinder, an arcuate scale, and a circular tube. 2. The portable mechanical pain sensitivity detector according to claim 1, characterized in that the upper and lower ends of the shaft have concave interfaces, the concave interface at the upper end is connected to the base of the probe, and the concave interface at the lower end is connected by a screw metallic line. 3. The portable mechanical pain sensitivity tester according to claim 1, characterized in that the shaft is in the middle of the disc and is vertical to the disc, and the shaft passes through the tube and the cylinder sequentially inside the cylinder Bottom, after passing through, connect the metal wire with the upper screw just below the bottom of the cylinder. 4. The portable mechanical pain sensitivity detector according to claim 3, characterized in that the disc is embedded in the opening at the upper end of the cylinder. 5. The portable mechanical pain sensitivity detector according to claim 1, characterized in that the bottom of the cylinder is closed, and an upward circular tube is vertically fixedly connected to the center of the bottom, and a section of the bottom of the core is in the circular tube. 6. The portable mechanical pain sensitivity tester according to claim 1, wherein the metal wire is elastic and arc-shaped, the lower end points to the concave surface of the arc-shaped scale, and the lower end is connected with the metal tube as an integral structure. 7. The portable mechanical pain sensitivity detector according to claim 5, characterized in that the metal tube is made of magnetic material. 8. The portable mechanical pain sensitivity detector according to claim 1, characterized in that the curved scale is made of magnetically conductive metal. 9. The portable mechanical pain sensitivity tester according to claim 7, characterized in that the arcuate scale is at the bottom of the cylinder and is integrally formed by part of the cylinder wall continuing downward. 10. The portable mechanical pain sensitivity tester according to claim 1, characterized in that the spring is inside the cylinder and outside the tube, the upper end is connected to the lower part of the disc of the core, and the lower end is connected to the cylinder of the cylindrical part bottom.