CN105412706A - Traditional Chinese medicine composition for treating female endocrine dyscrasia - Google Patents

Abstract

Provided is a traditional Chinese medicine composition for treating female endocrine dyscrasia. The traditional Chinese medicine composition is prepared from fructus ligustri lucidi, polygonum multiflorum, herba leonuri, caulis spatholobi, bamboo shavings, radix notoginseng, indigowoad leaves, gingko leaves, coix seeds, herba dendrobii, pericarpium citri reticulatae viride, Szechwan chinaberry fruit, fructus piperis longi, safflower, semen cuscutae, radix linderae, natural indigo, radix lithospermi, cortex moutan, dried human placenta, radix polygalae, milkvetch roots, finger citron, cortex eucommiae, rubus idaeus, roses, radix puerariae, dandelions, periostracum cicadae, herba cistanches, epimedium herb, tuber fleeceflower stems, cortex magnoliae officinalis and herba artemisiae scopariae. The traditional Chinese medicine composition is prominent in curative effect, quick in effect, not prone to relapse, safe and free of side effect, common Chinese herbal medicines serve as the raw materials, the production cost is low, and the traditional Chinese medicine composition is suitable for application and promotion.

Description

A kind of Chinese medicine composition for the treatment of female endocrine dyscrasia

Technical field

The invention belongs to medical art, relate to a kind of Chinese medicine composition, be specifically related to a kind of Chinese medicine composition for the treatment of female endocrine dyscrasia.

Background technology

Healthy human body is the metabolism and the physiological function that are regulated human body by the various hormone of hormonal system together with nervous system.Hormonal system is many physiological activities such as participate in regulating the metabolic process of human body, growth promoter, reproduction old and feeble and biosis, and collaborative various ferment maintain the relative stability of human internal environment, to adapt to inside and outside change complicated and changeable.Endocrine is the regulation and control person of human physiological functions, and it is played a role in human body by secreting hormone.Such as, antibacterial enters human body, and thymosin just can increase secretion automatically, to resist pathogenic bacteria; Female menstrual period, progestogen also can increase, and estrogen is corresponding minimizing then.If because some cause of disease, the hormonosis causing endocrine gland to secrete or very few, metabolic function is disorderly, will cause endocrine disturbance, cause endocrinopathy to occur, comprise female acyesis.

Under normal circumstances various hormone be keep balance, as because of certain reason, this balance is broken (certain hormonosis or very few) this just cause endocrine disturbance, corresponding clinical manifestation can be caused.Modern female, due to operating pressure and environmental factors, is much in subhealth state and endocrine disturbance's state.The common manifestation of endocrine disturbance: luteal phase defect is the infertile modal performance of dyscrinic.Women's luteal phase defect has many harm to health.Luteal phase defect main manifestations be menstrual cycle shorten but menstrual period normal, through to measure normally or slightly many, companion's history of spontaneous abortion.Often auxiliary examination need be relied on to make a definite diagnosis.In fact, the Recurrent spontaneous abortion of nearly 35% ~ 40% is caused by luteal phase defect.During normal pregnancy, ovum starts the implantation of film implantation in uterus at after fertilization 5 ~ 7d, and trophoblastic cell starts to secrete chorionic-gonadotropin hormone (HCG), and HCG stimulates corpus luteum continuation growth to grow up, and becomes corpus luteum of pregnancy, makes progesterone continue to produce.When gestation plays luteal function decline for 6 weeks, trophoblast synthesis progesterone starts.Therefore the most easily miscarry when pregnant 6 ~ 7 weeks.As luteal phase defect comprises the corpus luteum lost of life, and corpus luteum secretory function is low, so that progesterone secretion quantity not sufficient, after the bad or early pregnancy of endometrial secretory reaction, decidua reaction is bad, cause cytula not easily after implantation or implantation development of fertilized ovum be affected, cause miscarriage.Luteal phase defect is large on female pathology impact, and women occurs that the symptom of luteal phase defect needs timely hospital treatment.

Disease reason:

1, ovulation failure: the various endocrine function ovulation failure caused of lacking of proper care all can directly cause infertile.

2, congenital disorders of sex differentiation: mainly comprise Hyperandrogenism, hypoandrogenism, the diseases such as androgen dysfunction.3, the amenorrhea that causes of endocrine factors: amenorrhea is a kind of extremely form of infrequent menstruation.Primary amenorrhea and secondary amenorrhea can be divided into.Primary amenorrhea to refer to after women 18 one full year of life the still menolipsis person of rising; Secondary amenorrhea refers to once well-regulated menstruation, and causes for a certain reason and stop menstruation more than 3 months persons.4, polycystic ovary syndrome: there is menoxenia, amenorrhea, anovulation hirsutism, obesity, the increase of infertile merging bilateral ovaries in many capsule changes.5, hirsutism is with manlike: hirsutism refers to compared with women and its women of the same age of the same clan, or compared with before he or she's disease, hair undue growth, thicker, blackening.Manlike is a kind of clinical syndrome, refers to that women is except performance hirsutism, still have clitoridauxe, muscular, have a low and deep voice, facial acne, male pattern alopecia, women's secondary sex characteristics go down or disappear and amenorrhea etc.Hirsutism and butch be to increase in various degree or caused by whole non-organ increases androgenic sensitivity because a variety of causes causes body inner estrogen level.6, high lactogenic mass formed by blood stasis: Prolactin is abnormal too high infertilely or sterile comprises amenorrhea, galactorrhea, hypomenorrhea and rare, luteal phase defect and ovulation.7, thyroid: hyperthyroidism, go down, struma lymphomatosa etc. all can affect ovulation and cause infertile.9, luteal phase defect: menstruation in advance, dripping not to the utmost, palace blood forms anovulation type menstruation etc.10, other as: diabetes, adrenal gland's cryptorrhea etc. also can affect ovary ovulation.

The medicine of the existing endocrine disturbance of being used for the treatment of mostly is western medicine composition in the market, and as hormones, its side effect is large, and function ratio is more single, fundamentally can not improve the problem of human endocrine imbalance.Therefore how overcoming the deficiencies in the prior art is problems that current technical field of Chinese medicines needs solution badly.

Summary of the invention

The present invention is directed to weak point of the prior art, provide a kind of Chinese medicine composition for the treatment of female endocrine dyscrasia, this Chinese medicine composition is based on blood yiqi, enriching yin and nourishing kidney, raising immunity of organisms, can prevent controlling, curative effect is given prominence to, instant effect, not easily recur, safety has no side effect.

For achieving the above object, present invention employs following technical scheme:

Treat a Chinese medicine composition for female endocrine dyscrasia, the crude drug of described Chinese medicine composition is made up of Fructus Ligustri Lucidi, Radix Polygoni Multiflori, Herba Leonuri, Caulis Spatholobi, Caulis Bambusae In Taenia, Radix Notoginseng, Folium Isatidis, Folium Ginkgo, Semen Coicis, Herba Dendrobii, Pericarpium Citri Reticulatae Viride, Fructus Toosendan, Fructus Piperis Longi, Flos Carthami, Semen Cuscutae, the Radix Linderae, Indigo Naturalis, Radix Arnebiae (Radix Lithospermi), Cortex Moutan, Placenta Hominis, Radix Polygalae, the Radix Astragali, Fructus Citri Sarcodactylis, the Cortex Eucommiae, Fructus Rubi, Flos Rosae Rugosae, Radix Puerariae, Herba Taraxaci, Periostracum Cicadae, Herba Cistanches, Herba Epimedii, Caulis Polygoni Multiflori, Cortex Magnoliae Officinalis, Herba Artemisiae Scopariae.

Further, crude drug composition and the parts by weight of making described Chinese medicine composition are: Fructus Ligustri Lucidi 11-14 part, Radix Polygoni Multiflori 9-15 part, Herba Leonuri 3-6 part, Caulis Spatholobi 8-13 part, Caulis Bambusae In Taenia 3-5 part, Radix Notoginseng 1-3 part, Folium Isatidis 5-10 part, Folium Ginkgo 5-10 part, Semen Coicis 3-10 part, Herba Dendrobii 8-13 part, Pericarpium Citri Reticulatae Viride 3-5 part, Fructus Toosendan 1-3 part, Fructus Piperis Longi 9-15 part, Flos Carthami 3-7 part, Semen Cuscutae 8-13 part, Radix Linderae 3-6 part, Indigo Naturalis 8-13 part, Radix Arnebiae (Radix Lithospermi) 3-5 part, Cortex Moutan 11-15 part, Placenta Hominis 5-10 part, Radix Polygalae 2-5 part, Radix Astragali 4-9 part, Fructus Citri Sarcodactylis 12-20 part, Cortex Eucommiae 10-16 part, Fructus Rubi 3-8 part, Flos Rosae Rugosae 5-12 part, Radix Puerariae 12-17 part, Herba Taraxaci 7-12 part, Periostracum Cicadae 4-9 part, Herba Cistanches 15-20 part, Herba Epimedii 10-15 part, Caulis Polygoni Multiflori 8-12 part, Cortex Magnoliae Officinalis 2-5 part, Herba Artemisiae Scopariae 3-7 part.

Further, described Chinese medicine composition is prepared according to following method:

(1) pulverized by pulverizer after each crude drug of described components by weight percent proportionally being mixed, be ground into 100 order ~ 200 object powder, adding determining alcohol is 85% ~ 90% alcohol reflux 2.5 ~ 4 hours, the ethanol quality added is 3.5 ~ 5 times of mixture quality, filter, obtain filtering liquid medicine, the extractum of 1.3-1.4 when concentrating under reduced pressure becomes relative density to be 80 DEG C, heating is concentrated into paste, stand for standby use;

(2) medicinal residues that ethanol extraction in step (1) is crossed are put into 10-12 times of water gaging, then put into extraction pot heated and boiled 1.5-2 hour, filter, filtrate is for subsequent use; Filtering residue adds water, and second time heating, boils 45 minutes, and filter, filtrate is for subsequent use;

(3) 2 filtrates in step (2) be combined, by filtered through gauze, add 50-60% ethanol in residue, 60 DEG C-70 DEG C are continued lixiviate 2-3h, and every 10min stirs once, filtered through gauze, merge lixiviating solution, are condensed into pasty state;

(4) the pastel decompression recycling ethanol concentrated for step (1) paste that obtains and step (3) obtained also is concentrated into 1.15-1.20 when relative density is about 20 DEG C, centrifugal under the rotating speed of 3000r/min, at 60 DEG C of-80 DEG C of spraying dry, obtain dry extract;

(5) dry extract obtained for step (4) is placed in super micron mill pulverizes 1.5-2 hour, pulverize, sieve, obtain 350-400 object micropowders;

(6) micropowders that step (5) is obtained is added appropriate micropowder silica gel, α-galactose mixing, take ethanol as wetting agent, granulate, dry, granulate, encapsulated, obtained capsule.

Further, described Chinese medicine composition is prepared according to following method:

(1) pulverized by pulverizer after each crude drug of described components by weight percent proportionally being mixed, be ground into 100 order ~ 200 object powder, adding determining alcohol is 85% ~ 90% alcohol reflux 2.5 ~ 4 hours, the ethanol quality added is 3.5 ~ 5 times of mixture quality, filter, obtain filtering liquid medicine, the extractum of 1.3-1.4 when concentrating under reduced pressure becomes relative density to be 80 DEG C, heating is concentrated into paste, stand for standby use;

(2) medicinal residues that ethanol extraction in step (1) is crossed are put into 10-12 times of water gaging, then put into extraction pot heated and boiled 1.5-2 hour, filter, filtrate is for subsequent use; Filtering residue adds water, and second time heating, boils 45 minutes, and filter, filtrate is for subsequent use;

(3) 2 filtrates in step (2) be combined, by filtered through gauze, add 50-60% ethanol in residue, 60 DEG C-70 DEG C are continued lixiviate 2-3h, and every 10min stirs once, filtered through gauze, merge lixiviating solution, are condensed into pasty state;

(4) the pastel decompression recycling ethanol concentrated for step (1) paste that obtains and step (3) obtained also is concentrated into 1.15-1.20 when relative density is about 20 DEG C, centrifugal under the rotating speed of 3000r/min, at 60 DEG C of-80 DEG C of spraying dry, obtain dry extract;

(5) dry extract obtained for step (4) is placed in super micron mill pulverizes 1.5-2 hour, pulverize, sieve, obtain 350-400 object micropowders;

(6) micropowders that step (5) is obtained is added suitable amount of sucrose, dextrin mixing, take ethanol as wetting agent, granulate, dry, granulate, tabletting, obtained tablet.

Further, described Chinese medicine composition is prepared according to following method:

(1) pulverized by pulverizer after each crude drug of described components by weight percent proportionally being mixed, be ground into 100 order ~ 200 object powder, adding determining alcohol is 85% ~ 90% alcohol reflux 2.5 ~ 4 hours, the ethanol quality added is 3.5 ~ 5 times of mixture quality, filter, obtain filtering liquid medicine, the extractum of 1.3-1.4 when concentrating under reduced pressure becomes relative density to be 80 DEG C, heating is concentrated into paste, stand for standby use;

(2) medicinal residues that ethanol extraction in step (1) is crossed are put into 10-12 times of water gaging, then put into extraction pot heated and boiled 1.5-2 hour, filter, filtrate is for subsequent use; Filtering residue adds water, and second time heating, boils 45 minutes, and filter, filtrate is for subsequent use;

(3) 2 filtrates in step (2) be combined, by filtered through gauze, add 50-60% ethanol in residue, 60 DEG C-70 DEG C are continued lixiviate 2-3h, and every 10min stirs once, filtered through gauze, merge lixiviating solution, are condensed into pasty state;

(4) the pastel decompression recycling ethanol concentrated for step (1) paste that obtains and step (3) obtained also is concentrated into 1.15-1.20 when relative density is about 20 DEG C, centrifugal under the rotating speed of 3000r/min, at 60 DEG C of-80 DEG C of spraying dry, obtain dry extract;

(5) dry extract obtained for step (4) is placed in super micron mill pulverizes 1.5-2 hour, pulverize, sieve, obtain 350-400 object micropowders;

(6), after the micropowders that step (5) is obtained being added suitable amount of sucrose, dextrin mixing, take ethanol as wetting agent, granulate, dry, granulate, obtained granule.

The invention still further relates to the application of Chinese medicine composition in treatment female endocrine dyscrasia medicine of described treatment female endocrine dyscrasia.

The Chinese medicine composition for the treatment of female endocrine dyscrasia provided by the present invention, it for raw material, gives full play to the property of medicine of each component with common Chinese herbal medicine:

Fructus Ligustri Lucidi, sweet, bitter, cold.Return liver, kidney channel.Invigorating the liver and kidney, strong waist knee joint.Control yin asthenia generating intrinsic heat, dizzy, order flower, tinnitus, soreness of the waist and knees, early whitening of beard and hair.Nourishing the liver and kidney, improving eyesight black hair.For vertigo and tinnitus, soreness of the waist and knees, early whitening of beard and hair, poor vision." book on Chinese herbal medicine just ": " yin nourishing gas, Pingyin fire, separates dysphoria with smothery sensation hectic fever due to YIN-deficiency, and only sweating due to debility, quenches one's thirst, and stranguria with turbid discharge, and metrorrhagia, has blood in stool, hematuria, the erosion of vulva, anal fistula pain.Also clearing away liver-fire, can improving eyesight arresting lacrimation.”

Radix Polygoni Multiflori, bitter in the mouth, sweet; Puckery, slightly warm in nature, returns liver, kidney channel.Mainly contain nourishing the blood and yin, loosening bowel to relieve constipation, preventing the attack (or recurrence) of malaria, dispel the wind, detoxify.Cure mainly blood deficiency Light-headedness, cardiopalmus, insomnia, the soreness of the waist and knees of the hepatic and renal YIN deficiency, early whitening of beard and hair, tinnitus, seminal emission, dryness of the intestine constipation, chronic malaria body void, rubella pruritus, carbuncle sore, scrofula, hemorrhoid etc.

Herba Leonuri: acrid-sweet flavor, feeble QI temperature, nontoxic.Enter the heart, liver, urinary bladder channel.Invigorate blood circulation, blood stasis dispelling, regulating menstruation, disappear water.Control menoxenia, vaginal bleeding during pregnancy is had difficult labour, and retention of placenta, puerperal blood faints, abdominal pain due to blood stasis, metrorrhagia and metrostaxis, hematuria, rushes down blood, carbuncle skin infection.

Caulis Spatholobi: bitter in the mouth, micro-sweet, warm in nature; Return liver, the heart, kidney channel.Relaxing muscles and tendons to promote blood circulation, nourishing blood for regulating menstruation.Cure mainly rheumatic arthralgia, numb hand and foot, quadriplegia, menoxenia, blockage of menstruation, dysmenorrhea, amenorrhea, leukopenia.

Caulis Bambusae In Taenia: sweet, is slightly cold.Return lung, stomach, the heart, gallbladder meridian.There is removing heat-phlegm, relieving restlessness, effect of preventing or arresting vomiting.For phlegm-heat cough, expectorant held under the arm by gallbladder fire, and palpitation with fear is not peaceful, vexed insomnia, middle wind-phlegm fan, aphasia with stiff tongue, gastropyretic vomiting, pregnancy reactions, frequent fetal movement.

Radix Notoginseng: the sweet mildly bitter flavor of Radix Notoginseng property, warm in nature, return liver, stomach through being used as medicine with root, root stock.Rare Chinese medicine, raw with can hemostasia and dissipation blood stasis, reducing swelling and alleviating pain, there is good hemostasia effect, significant hemopoietic function; Can tighten and improve Coronary microcirculation, Radix Notoginseng is used as medicine with a long history, acts on the peculiar treasured be considered as by ancient Chinese medicine doctor in medicine, therefore has the saying of " Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) "." taste is micro-sweet and bitter, quite like the taste of Radix Ginseng for Radix Notoginseng." " all canes flutter trauma, and the dripping person of blood stasis, chew namely stopping of rotten net for catching birds or fish immediately, namely bruise person dissipate.If during by cane, first take one, two money, then the blood not centre of punch, should take it after cane especially, puerperal, clothes were also good.On the whole this medicine temperature, sweet and slightly bitter taste, and sun is bright, the medicine of cloudy blood system of fainting, therefore all disorders of blood can be controlled "." book on Chinese herbal medicine is looked for the truth " is recorded: " Radix Notoginseng, common people only know function hemostasis and pain-relieving.Hardly realize that pain aches work because of blood stasis, because applying loose, blood stops blood.The bitter temperature of Radix Notoginseng abnormal smells from the patient, can in its blood stasis of blood systemization." Radix Notoginseng can increase coronary flow, decreased heart rate, reduces myocardial oxygen consumption, increases myocardium oxygen-resistant ability, improve microcirculation, removes the effect of smooth muscle spasm.

Folium Isatidis: bitter in the mouth, cold in nature.Return liver, the heart, stomach, spleen channel.Heat-clearing and toxic substances removing, blood cooling and ecchymoses removing.For the high hot excessive thirst of calentura; Coma; Macule; Spit blood; Epistaxis; Jaundice; Dysentery; Erysipelas; Sore throat; Aphtha; Mumps.

Folium Ginkgo: in the 2000th version pharmacopeia (one), Folium Ginkgo is loaded into as official drug, calls it: nature and flavor are sweet, bitter, puckery, flat, GUIXIN lung meridian, function is astringed the lung, relieving asthma, blood circulation promoting and blood stasis dispelling, pain relieving, for cough and asthma due to lung deficiency, coronary heart diseases and angina pectoris, hyperlipidemia.

Semen Coicis, sweet in the mouth, light, cold nature.Return spleen, stomach, lung meridian.Energy promoting diuresis to eliminate damp pathogen, damp eliminating eliminating impediment, invigorating the spleen to arrest diarrhea, clearing away heat and discharging pus.Cure mainly dysuria, edema, beriberi, arthralgia chiefly caused by damp pathogen contracture, hygropyrexia from the beginning of and the card such as diarrhea due to hypofunction of the spleen, lung abscess, acute appendicitis.

Herba Dendrobii: sweet, is slightly cold.Return stomach, kidney channel.Effect with cure mainly: reinforcing stomach reg fluid, nourishing YIN and clearing away heat.Lose for cloudy impairment of body fluid, xerostomia excessive thirst, lack of appetite is retched. deficiency-heat after being ill. and poor vision.

Pericarpium Citri Reticulatae Viride: bitter in the mouth, pungent, warm in nature, enter liver, gallbladder, stomach warp, there is the effect that easypro gallbladder dispelling the stagnated QI, removing food stagnancyization are stagnant, for stagnation of QI due to dyspepsia, abdominal distention, infantile malnutrition, old man stops eating abdominal distention, gentle stimulation is had to gastrointestinal tract, can facilitating digestion liquid secretion and get rid of gas in body, again can diastole gastrointestinal smooth muscle, main manifestations is the effect of adjustment gastrointestinal function.

Fructus Toosendan: Chinese crude drug is the mature fruit of Meliaceae deciduous tree toosendanin, cold in nature, and bitter in the mouth is the one of qi-activating drug.There are soothing liver-QI promoting the circulation of QI to relieve pain, the drug effect of anthelmintic.For the breast side of body, abdominal distention, colic, abdominal pain due to worm stagnation.But also be make efficiently without the important source material of the free of contamination novel plant pesticide of residual hazard.The sedimentation of Fructus Toosendan bitter cold, mainly enters Liver Channel, catharsis liver-heat, and promoting the circulation of QI to relieve pain, control the stagnation of QI and have the card of heat especially suitable.

Fructus Piperis Longi, acrid in the mouth, warm in nature, return stomach, spleen, kidney channel, there is cold relieving, invigorate blood circulation, warming YANG, blood stasis dispelling, the effect such as to regulate the flow of vital energy, be mainly used in the diseases such as treatment angina pectoris, stomachache, diarrhoea.

Flos Carthami is warm in nature, acrid in the mouth.Function cures mainly and is applied to latus rectum of invigorating blood circulation, eliminating stasis to stop pain.For amenorrhea, dysmenorrhea, lochia, lump in the abdomen mass in the abdomen, traumatic injury." book on Chinese herbal medicine converge with speech ": Flos Carthami, the medicine of removing blood stasis, promoting the circulation of blood and blood, tune blood also.Main tire produces all kinds of diseases and ailments because blood is for suffering from, or blood is tired of bruise, and coma in silence; Or lochia robs the heart, umbilicus angina abdominis; Or drop slurry is difficult raw; Or afterbirth does not fall, dead fetus in the uterus, be all just before giving birth all cards, non-Flos Carthami can not be controlled.If puerperal blood faints, locked mouth refer to hold in the hand; Or heresy enters blood room, delirium is gone mad; Or blood is vexed interior swollen, sudden syncope with rigidity as extremely, be all puerperal all cards, non-Flos Carthami can not be determined.All as obstructed in amenorrhea and cold and heat are handed over and are done, or expired stomachache and purple black dripping, or injury from falling down and the QI and blood stasis of blood are amassed, or skin infection sufferings and swollen burst uneasy, be the card of all disharmony between QI and blood, non-Flos Carthami can not be adjusted, Flos Carthami promoting blood circulation to restore menstrual flow, reducing swelling and alleviating pain, there are inhibition thrombosis, antiinflammatory, analgesic effect, there is the vasoconstrictive effect eliminating epinephrine, norepinephrine, have " tonneau passages through which vital energy circulates " to act on.

Semen Cuscutae is the dry mature seed of convolvulaceous plant Cuscuta australis CuscutaaustralisR.Br. or Semen Cuscutae CuscutachinensisLam..Pungent, sweet, flat.Return liver,kidney,spleen warp.Can liver and kidney tonifying, controlling nocturnal emission with astringent drugs reducing urination, antiabortive, improving eyesight, antidiarrheal; External pathogenic wind expelling speckle dispelling.For deficiency of the liver and kindey, soreness of the waist and knees, impotence and seminal emission, enuresis frequent micturition.Vaginal bleeding due to deficiency of the kidney during pregnancy, frequent fetal movement, blurred vision tinnitus, spleen is suffered from a deficiency of the kidney and is rushed down; Externally treating leucoderma.

The Radix Linderae: pungent, yearningly.Return lung, spleen, kidney, urinary bladder channel.Effect with cure mainly: pleasant pain relieving, warming kidney for dispelling cold.For chest and abdomen swelling and pain, QI rising in reverse order dyspnea with rapid respiration, deficiency-cold in the urinary bladder, enuresis frequent micturition, hernia, dysmenorrhea.

Indigo Naturalis, salty, cold.Return Liver Channel.Heat-clearing and toxic substances removing, removing heat from blood, arresting convulsion.For maculae caused by violent heat pathogen, heat in blood tells nosebleed, chest pain hemoptysis, aphtha, mumps, sore throat, pediatric epilepsy scared.

Radix Arnebiae (Radix Lithospermi) is sweet, salty, cold.GUIXIN, Liver Channel.Function cures mainly: removing heat from blood, invigorates blood circulation, removing toxic substances rash.Contain for heat in blood poison, macule purple is black, measles without adequate eruption, skin infection, eczema, burn due to hot liquid or fire.

Cortex Moutan, bitter, pungent, be slightly cold.GUIXIN, liver, kidney channel.Clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling.For maculae caused by violent heat pathogen, hematemesis and epistaxis, night fever abating at dawn, lossless hectic fever due to YIN-deficiency, amenorrhea dysmenorrhea, carbuncle sore tumefacting virus, falls and flutters the pain of injury.

Placenta Hominis: sweet, salty, temperature.GUIXIN, lung, kidney channel.Effect with cure mainly: the kidney warming mends essence, benefiting QI and nourishing blood.Win thin for asthenia, hectic fever due to YIN-deficiency night sweat, cough and asthma, lack of appetite is breathed hard, impotence and seminal emission, infertile hypogalactia.

Radix Polygalae is conventional Chinese medicine, be recorded in Shennong's Herbal the earliest, be classified as top grade, and be regarded as supporting life key medicine, warm in nature, bitter in the mouth, pungent, the function of there is Fructus Alpiniae Oxyphyllae of calming the nerves, eliminate the phlegm, subsiding a swelling, the insomnia and dreamful sleep caused for disarmony between the heart and kidney, forgetful palpitation with fear, staring spells, expectoration is not well, sore swollen toxin, breast swell and pain.

The Radix Astragali, nature and flavor are sweet, slightly warm in nature, there is enhancing human body immunity function, protect the liver, diuresis, defying age, anti-stress, blood pressure lowering, antibacterial effect, Jishengshenqiwan albuminuria can also be eliminated, strengthen myocardial contraction, regulate blood sugar content.The Radix Astragali can not only coronary artery dilator, improves blood supply of cardiac muscle, improves immunologic function, and can the process of delaying cell aging, weak for exterior deficiency spontaneous perspiration, night sweat due to yin deficiency, the deficiency of vital energy, fatigue and weakness, or the disease such as sinking of QI of middle-JIAO, proctoptosis, uterine prolapse.

Fructus Citri Sarcodactylis: pungent, bitter, sour, temperature; Return liver, spleen, lung meridian." the southern regions of the Yunnan Province book on Chinese herbal medicine ": " Fructus Citri Sarcodactylis disappears cold syndrome of the stomach expectorant, controls gastric qi pain, the only cold pain in face, and middle circulation of qi promoting for tonifying liver warming the stomach, anti-nausea." " book on Chinese herbal medicine is new again ": " control gas soothing liver-QI, stomach function regulating reduces phlegm, and removing mass controls dysphagia and regurgitation, eliminating mass abdominal mass scrofula." liver-smoothing, qi-regulating, and stomach and alleviating pain.For stagnation of liver-QI and stomach-QI, distending pain in the chest and hypochondrium, gastral cavilty feeling of fullness, lack of appetite is vomitted.

The Cortex Eucommiae, warm in nature, sweet in the mouth, there is invigorating the liver and kidney, strong waist knee joint, bone and muscle strengthening, antiabortive effect, have regulating action in various degree to immune system, hormonal system, central nervous system, blood circulation and urinary system, can excited Pituitary Adrenalcortical system, adrenal cortex reinforcing function, for spinal column ache, foot and knee flaccidity, dribbling urination, uncontrolled urination is itched, vaginal bleeding during pregnancy for falling, frequent fetal movement, the diseases such as hypertension.

Fructus Rubi: base is former: for the dry fruit of basin is covered in Rosaceae rubus East China.Nature and flavor with return through: sweet, sour, temperature.Return liver, kidney, urinary bladder channel.Function with cure mainly: supplementing the kidney to control the nocturnal reducing urination, nourishing the liver to improve visual acuity.For emission and spermatorrhea, enuresis frequent micturition, impotence and premature ejaculation, order is secretly dim-sighted.

Flos Rosae Rugosae, sweet, micro-hardship, temperature.Return liver, spleen channel.For promoting QI circulation for relieving depression, and blood, pain relieving.For stomachache due to hyperactive liver-QI attacking the stomach, lack of appetite vomiting and nausea, menoxenia, falls and flutters the pain of injury.

Radix Puerariae, sweet in the mouth, pungent, cool in nature.Enter spleen, stomach warp.There is yang invigorating expelling pathogenic factors from muscles, rash antidiarrheal, effect that relieving restlessness is only warm.For typhoid fever, warm headache stiffness of the nape, dysphoria with smothery sensation is quenched one's thirst, and has loose bowels, dysentery, and skin eruption is not saturating, hypertension, and angina pectoris is deaf.Be used for Hypertension neck pain, angina pectoris clinically, but also there is hypoglycemic activity.

Herba Taraxaci: be feverfew Herba Taraxaci TaraxacummongolicumHand.-Mazz., alkali ground Herba Taraxaci TaraxacumsinicumKitag. or the dry herb belonging to several plants together.Heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, inducing diuresis for treating stranguria syndrome.For furuncle swelling toxin, acute mastitis, scrofula, conjunctival congestion, pharyngalgia, lung abscess, acute appendicitis, jaundice due to damp-heat, the puckery pain of pyretic stranguria.

Periostracum Cicadae: sweet in the mouth; Salty; Cool in nature.Enter lung; Liver Channel.Dispelling wind-heat; Rash sore-throat relieving; Removing nebula to improve visual acuity; Expelling wind and relieving convulsion.Cure mainly anemopyretic cold; Laryngopharynx swelling and pain; Cough hoarseness; Stupid rash is not saturating; Rubella pruritus; Cataract; Infantile convulsion is twitched; Tetanus." detailed outline " carries: " control phlegm-accumulating vertigo, skin wind heat, varioliform exanthema is had an itch, tetanus and treatment toxic swelling tumor, and adult's aphonia, children's's lockjaw sky hangs, frightened night cry of crying, swelling of the vulva." modern medicine study confirmation; Periostracum Cicadae has obvious convulsion, sedation, can block parasympathetic conduction on neck, is widely used in treatment tetanus, chronic Herba Urticae Cannabinae is examined, suppurative otitis media, vasodilation; also have cough-relieving to cough in addition, the particularly effect coughed of itching of the throat.

Herba Cistanches, sweet, salty, temperature.Return kidney, large intestine channel.Kidney-replenishing, benefiting essence-blood, loosening bowel to relieve constipation.For sexual impotence, infertile, soreness of the waist and knees, muscles and bones is unable, dryness of the intestine constipation." herbal classic ": " main five kinds of strain and seven kinds of impairment, invigorating middle warmer, except stem invasion by pathogenic cold burning pain, support the five internal organs, reinforcing YIN-essence, beneficial vital essence, gynecological mass in abdomen.”

Herba Epimedii, acrid in the mouth, sweet, warm in nature, return Liver Channel, kidney channel.Energy kidney-replenishing, bone and muscle strengthening, wind-damp dispelling.For impotence and seminal emission, muscles and bones flaccidity is soft, rheumatic arthralgia, numbness contracture; Climacteric hypertension.

Caulis Polygoni Multiflori: sweet micro-hardship is flat.Enter the heart, Liver Channel.Function cures mainly: nourish heart, and calms the nerves, and dredging collateral dispels the wind.Control insomnia, impairment caused by overstrain, hyperhidrosis, blood deficiency general pain, carbuncle, scrofula, wind skin ulcer scabies.

Cortex Magnoliae Officinalis: bitter, pungent, temperature.Return spleen, stomach, lung, large intestine channel.Effect with cure mainly: dampness expectorant, the therapeutic method to keep the adverse QI flowing downwards is except full.For humidity hysteresis damaging the spleen and stomach, gastral cavity painful abdominal mass is vomited and diarrhoea, and stagnation of QI due to dyspepsia, abdominal distention constipation, phlegm retention is breathed with cough.

Herba Artemisiae Scopariae: bitter in the mouth, pungent, cold nature.Return spleen, stomach, liver, gallbladder meridian.Function cures mainly: clearing away damp-heat, jaundice eliminating subcutaneous ulcer.For jaundice oliguria, eczema pruritus; Infectious jaundice type hepatitis." herbal classic ": the raw pathogenic heat gas of main air, accumulation of heat jaundice." not Lu ": control the whole body jaundice, dysuria, except feverish sensation in the head, removes mass in the large intestine.Supplement to the Herbal: get round by bribery, go stagnant heat, typhoid fever uses it." medical center bun is wanted ": hard kidney, dry spleen wets, and goes strongly fragrant, antipyretic." book on Chinese herbal medicine is new again ": pathogenic fire purging, suppressing the hyperactive liver, reduces phlegm, cough-relieving diaphoresis, dampness removing, detumescence, treats all poison of skin ulcer fire.

In the traditional Chinese medical science, endocrine disturbance is the performance of the deficiency of YIN, is to be retarded by silt by QI and blood caused.Congestion is detained in body, venation is obstructed, outer poison invasion human body, lochiostasis etc. all may cause that QI and blood is retarded by silt.A lot of women's commonly encountered diseases is all that disease is embodied in caused by endocrine disturbance: blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea in fact.Chinese traditional treatment endocrine disturbance is mainly based on Chinese medicine conditioning, physical condition according to everyone carries out dialectical treating, and Chinese medicine can deposit by purged body intracellular metabolite, balance women QI and blood, make hormonal system recover normal to run, generally carry out Chinese medicine conditioning by QI and blood regulating, blood stasis-eliminating and stagnation-dissipating.

Chinese medicine composition of the present invention meets the principle of drug matching, first fundamentally starts with, and the medicine being the monarch and his subjects with Radix Polygoni Multiflori, Herba Leonuri, Caulis Spatholobi, Radix Notoginseng, Fructus Piperis Longi, Placenta Hominis, Cortex Moutan, Radix Arnebiae (Radix Lithospermi), Folium Ginkgo, Flos Carthami is used for promoting blood flow to regulate menstruation, invigorating qi and benefiting blood; With Fructus Ligustri Lucidi, Caulis Bambusae In Taenia, Radix Notoginseng, Folium Isatidis, Semen Coicis, Herba Dendrobii, Pericarpium Citri Reticulatae Viride, Fructus Toosendan, Semen Cuscutae etc. for the medicine of assisting a ruler in governing a country plays coordinative role, invigorating the liver and kidney, hemostasia and dissipation blood stasis, heat-clearing and toxic substances removing, relax gallbladder dispelling the stagnated QI, Yin-nourishing and body fluid promoting, liver and kidney tonifying, promoting QI circulation for relieving depression, yang invigorating expelling pathogenic factors from muscles, strengthen the function of monarch drug and ministerial drug, and restrict the toxic and side effects of other drug.The patient of this Chinese medicine composition to the sick type of difference gives specific aim and strengthens, the same use of all medicines, and drug effect is gentle, the efficacy of a drug is lasting, thus reaches the alluvial of purged body intracellular metabolite, balance women QI and blood, make hormonal system recover normal to run, effect of enriching yin and nourishing kidney, thus effectively cure female endocrine dyscrasia.

The beneficial effect of this Chinese medicine composition is: curative effect is given prominence to, and instant effect, not easily recurs, and safety has no side effect, and with common Chinese herbal medicine for raw material, production cost is low, is suitable for applying.

Detailed description of the invention:

For making the object of the embodiment of the present invention, technical scheme and advantage clearly, below in conjunction with embodiment, technical scheme of the present invention is clearly and completely described.Obviously, described embodiment is a part of the present invention, instead of whole embodiments.Based on described embodiments of the invention, the every other embodiment that those of ordinary skill in the art obtain under without the need to the prerequisite of creative work, all belongs to the scope of protection of the invention.Except as otherwise noted, the percent of the amount of alcohol in the present invention is percentage by volume.

Embodiment 1:

A kind of Chinese medicine composition for the treatment of female endocrine dyscrasia of the present invention, comprise the raw material of Chinese medicine medicine of following weight: Fructus Ligustri Lucidi 14 grams, Radix Polygoni Multiflori 9 grams, Herba Leonuri 6 grams, Caulis Spatholobi 8 grams, Caulis Bambusae In Taenia 5 grams, Radix Notoginseng 1 gram, Folium Isatidis 10 grams, Folium Ginkgo 5 grams, Semen Coicis 10 grams, Herba Dendrobii 8 grams, 5 grams, Pericarpium Citri Reticulatae Viride, Fructus Toosendan 1 gram, Fructus Piperis Longi 15 grams, 3 grams, Flos Carthami, Semen Cuscutae 8 grams, the Radix Linderae 6 grams, Indigo Naturalis 8 grams, Radix Arnebiae (Radix Lithospermi) 3 grams, Cortex Moutan 15 grams, Placenta Hominis 5 grams, Radix Polygalae 3 grams, the Radix Astragali 5 grams, Fructus Citri Sarcodactylis 12 grams, the Cortex Eucommiae 16 grams, Fructus Rubi 3 grams, Flos Rosae Rugosae 12 grams, Radix Puerariae 12 grams, Herba Taraxaci 10 grams, Periostracum Cicadae 9 grams, Herba Cistanches 15 grams, Herba Epimedii 15 grams, Caulis Polygoni Multiflori 8 grams, Cortex Magnoliae Officinalis 5 grams, Herba Artemisiae Scopariae 3 grams.

Described Chinese medicine composition is prepared according to following method:

(1) pulverized by pulverizer after each crude drug of described components by weight percent proportionally being mixed, be ground into 100 order ~ 200 object powder, adding determining alcohol is 85% ~ 90% alcohol reflux 2.5 ~ 4 hours, the ethanol quality added is 3.5 ~ 5 times of mixture quality, filter, obtain filtering liquid medicine, the extractum of 1.3-1.4 when concentrating under reduced pressure becomes relative density to be 80 DEG C, heating is concentrated into paste, stand for standby use;

(2) medicinal residues that ethanol extraction in step (1) is crossed are put into 10-12 times of water gaging, then put into extraction pot heated and boiled 1.5-2 hour, filter, filtrate is for subsequent use; Filtering residue adds water, and second time heating, boils 45 minutes, and filter, filtrate is for subsequent use;

(3) 2 filtrates in step (2) be combined, by filtered through gauze, add 50-60% ethanol in residue, 60 DEG C-70 DEG C are continued lixiviate 2-3h, and every 10min stirs once, filtered through gauze, merge lixiviating solution, are condensed into pasty state;

(4) the pastel decompression recycling ethanol concentrated for step (1) paste that obtains and step (3) obtained also is concentrated into 1.15-1.20 when relative density is about 20 DEG C, centrifugal under the rotating speed of 3000r/min, at 60 DEG C of-80 DEG C of spraying dry, obtain dry extract;

(5) dry extract obtained for step (4) is placed in super micron mill pulverizes 1.5-2 hour, pulverize, sieve, obtain 350-400 object micropowders;

(6) micropowders that step (5) is obtained is added appropriate micropowder silica gel, α-galactose mixing, take ethanol as wetting agent, granulate, dry, granulate, encapsulated, obtained capsule; Or the micropowders that step (5) is obtained is added suitable amount of sucrose, dextrin mixing, and take ethanol as wetting agent, granulate, dry, granulate, tabletting, obtained tablet; Or after the micropowders that step (5) is obtained is added suitable amount of sucrose, dextrin mixing, take ethanol as wetting agent, granulate, dry, granulate, obtained granule.

Clinical data:

Zhao, female, 32 years old, Qingdao City Laoshan District people, in January, 2014 went to a doctor.Private prosecution: face occurs that mottle more than a year, and recent forehead also occurs, and more and more heavier, once repeatedly treats, but poor effect.Be diagnosed as: endocrine disturbance.Take tablet of the present invention one day three times, each three, sooner or later one after each meal, within 7 days, be a course for the treatment of, after 1 course for the treatment of, mottle obviously alleviates; Continue to take 2 courses for the treatment of, mottle disappears completely, cures.

Embodiment 2:

A kind of Chinese medicine composition for the treatment of female endocrine dyscrasia of the present invention, comprise the raw material of Chinese medicine medicine of following weight: Fructus Ligustri Lucidi 11 grams, Radix Polygoni Multiflori 15 grams, Herba Leonuri 3 grams, Caulis Spatholobi 13 grams, Caulis Bambusae In Taenia 3 grams, Radix Notoginseng 3 grams, Folium Isatidis 5 grams, Folium Ginkgo 10 grams, Semen Coicis 3 grams, Herba Dendrobii 13 grams, 3 grams, Pericarpium Citri Reticulatae Viride, Fructus Toosendan 3 grams, Fructus Piperis Longi 9 grams, 7 grams, Flos Carthami, Semen Cuscutae 10 grams, the Radix Linderae 4 grams, Indigo Naturalis 10 grams, Radix Arnebiae (Radix Lithospermi) 4 grams, Cortex Moutan 13 grams, Placenta Hominis 6 grams, Radix Polygalae 4 grams, the Radix Astragali 8 grams, Fructus Citri Sarcodactylis 20 grams, the Cortex Eucommiae 10 grams, Fructus Rubi 8 grams, Flos Rosae Rugosae 5 grams, Radix Puerariae 17 grams, Herba Taraxaci 12 grams, Periostracum Cicadae 4 grams, Herba Cistanches 20 grams, Herba Epimedii 10 grams, Caulis Polygoni Multiflori 12 grams, Cortex Magnoliae Officinalis 2 grams, Herba Artemisiae Scopariae 7 grams.

Preparation method is with embodiment 1.

Clinical data:

Money, female, 35 years old, Qingdao Jimo people, in March, 2014 went to a doctor.Patient's private prosecution: often want to fly into a rage, be off one's feed, hyposexuality, seems much old for sb.'s years.Be diagnosed as: endocrine disturbance.Take capsule of the present invention one day three times, each three, sooner or later one after each meal, within 7 days, be a course for the treatment of, after 1 course for the treatment of, appetite, libido are obviously improved; Continue to take 2 courses for the treatment of, symptom and sign all disappear, and cure.Follow up a case by regular visits to and do not recur half a year.

Embodiment 3:

A kind of Chinese medicine composition for the treatment of female endocrine dyscrasia of the present invention, comprise the raw material of Chinese medicine medicine of following weight: Fructus Ligustri Lucidi 12 grams, Radix Polygoni Multiflori 13 grams, Herba Leonuri 4 grams, Caulis Spatholobi 9 grams, Caulis Bambusae In Taenia 4 grams, Radix Notoginseng 2 grams, Folium Isatidis 6 grams, Folium Ginkgo 6 grams, Semen Coicis 5 grams, Herba Dendrobii 10 grams, 4 grams, Pericarpium Citri Reticulatae Viride, Fructus Toosendan 2 grams, Fructus Piperis Longi 10 grams, 5 grams, Flos Carthami, Semen Cuscutae 12 grams, the Radix Linderae 5 grams, Indigo Naturalis 12 grams, Radix Arnebiae (Radix Lithospermi) 3 grams, Cortex Moutan 12 grams, Placenta Hominis 9 grams, Radix Polygalae 4 grams, the Radix Astragali 7 grams, Fructus Citri Sarcodactylis 13 grams, the Cortex Eucommiae 11 grams, Fructus Rubi 4 grams, Flos Rosae Rugosae 6 grams, Radix Puerariae 13 grams, Herba Taraxaci 7 grams, Periostracum Cicadae 5 grams, Herba Cistanches 18 grams, Herba Epimedii 11 grams, Caulis Polygoni Multiflori 9 grams, Cortex Magnoliae Officinalis 4 grams, Herba Artemisiae Scopariae 6 grams.

Preparation method is with embodiment 1.

Clinical data:

Suddenly certain, female, 28 years old, people from Lixia District, Jinan City.Private prosecution: many speckles on the face, the nursing in several cycle of having gone to beauty parlor to do, speckle is light at the beginning, do not go out a month speckle and be presented on skin surface again, come institute and check, doctor says it is long on the face speckle because endocrine disturbance causes, do aesthetic nursing to cure the symptoms, not the disease, thoroughly can not eradicate speckle on the face.Take granule of the present invention one day three times, each three bags, one after each meal, 7 days is a course for the treatment of sooner or later, after 2 courses for the treatment of, find that speckle on the face starts desalination, skin starts to become smooth exquisiteness, after continuing to take four courses for the treatment of, facial skin exquisiteness is pale, and flexible, and speckle disappears entirely.

Embodiment 4:

A kind of Chinese medicine composition for the treatment of female endocrine dyscrasia of the present invention, comprise the raw material of Chinese medicine medicine of following weight: Fructus Ligustri Lucidi 13 grams, Radix Polygoni Multiflori 14 grams, Herba Leonuri 5 grams, Caulis Spatholobi 12 grams, Caulis Bambusae In Taenia 3 grams, Radix Notoginseng 1 gram, Folium Isatidis 10 grams, Folium Ginkgo 9 grams, Semen Coicis 7 grams, Herba Dendrobii 11 grams, 3 grams, Pericarpium Citri Reticulatae Viride, Fructus Toosendan 1 gram, Fructus Piperis Longi 12 grams, 6 grams, Flos Carthami, Semen Cuscutae 8 grams, the Radix Linderae 4 grams, Indigo Naturalis 11 grams, Radix Arnebiae (Radix Lithospermi) 4 grams, Cortex Moutan 14 grams, Placenta Hominis 8 grams, Radix Polygalae 3 grams, the Radix Astragali 6 grams, Fructus Citri Sarcodactylis 17 grams, the Cortex Eucommiae 15 grams, Fructus Rubi 7 grams, Flos Rosae Rugosae 11 grams, Radix Puerariae 16 grams, Herba Taraxaci 8 grams, Periostracum Cicadae 8 grams, Herba Cistanches 16 grams, Herba Epimedii 14 grams, Caulis Polygoni Multiflori 11 grams, Cortex Magnoliae Officinalis 3 grams, Herba Artemisiae Scopariae 5 grams.

Preparation method is with embodiment 1.

Clinical data:

Fourth, female, 45 years old, people from Laiyang, Yantai.Private prosecution: often fly into a rage, also with uncomfortable in chest, starts to think that climacteric has arrived.On inspection, the high liver fire that endocrine disturbance causes is diagnosed as.With capsule of the present invention a day three times, each three, one after each meal sooner or later, within 7 days, be a course for the treatment of, after 3 courses for the treatment of, symptom disappears entirely.

Embodiment 5:

A kind of Chinese medicine composition for the treatment of female endocrine dyscrasia of the present invention, comprise the raw material of Chinese medicine medicine of following weight: Fructus Ligustri Lucidi 11 grams, Radix Polygoni Multiflori 11 grams, Herba Leonuri 5 grams, Caulis Spatholobi 10 grams, Caulis Bambusae In Taenia 5 grams, Radix Notoginseng 3 grams, Folium Isatidis 8 grams, Folium Ginkgo 8 grams, Semen Coicis 9 grams, Herba Dendrobii 12 grams, 5 grams, Pericarpium Citri Reticulatae Viride, Fructus Toosendan 3 grams, Fructus Piperis Longi 13 grams, 3 grams, Flos Carthami, Semen Cuscutae 13 grams, the Radix Linderae 6 grams, Indigo Naturalis 9 grams, Radix Arnebiae (Radix Lithospermi) 5 grams, Cortex Moutan 12 grams, Placenta Hominis 7 grams, Radix Polygalae 5 grams, the Radix Astragali 9 grams, Fructus Citri Sarcodactylis 15 grams, the Cortex Eucommiae 12 grams, Fructus Rubi 5 grams, Flos Rosae Rugosae 9 grams, Radix Puerariae 15 grams, Herba Taraxaci 9 grams, Periostracum Cicadae 7 grams, Herba Cistanches 19 grams, Herba Epimedii 13 grams, Caulis Polygoni Multiflori 10 grams, Cortex Magnoliae Officinalis 4 grams, Herba Artemisiae Scopariae 4 grams.

Preparation method is with embodiment 1.

Clinical data:

Zhen Nv, female, 27 years old, people from Yishui, Linyi.Private prosecution: often insomnia, dreaminess, cold perspiration, menoxenia, sexual life aspect indifference, patient is very worried, introduces to our hospital through friend, is diagnosed as neurasthenia that endocrine disturbance causes, suffers from a deficiency of the kidney, sexual disorder.Take granule of the present invention one day three times, each three bags, one after each meal, 7 days is a course for the treatment of sooner or later, after 2 courses for the treatment of, sleep state is improved, and other symptom also takes a turn for the better to some extent, after continuing to take 2 courses for the treatment of of the present invention, symptom is eliminated gradually, and whole people becomes confidence.

Embodiment 6:

A kind of Chinese medicine composition for the treatment of female endocrine dyscrasia of the present invention, comprise the raw material of Chinese medicine medicine of following weight: Fructus Ligustri Lucidi 11 grams, Radix Polygoni Multiflori 11 grams, Herba Leonuri 5 grams, Caulis Spatholobi 10 grams, Caulis Bambusae In Taenia 5 grams, Radix Notoginseng 3 grams, Folium Isatidis 8 grams, Folium Ginkgo 8 grams, Semen Coicis 4 grams, Herba Dendrobii 9 grams, 5 grams, Pericarpium Citri Reticulatae Viride, Fructus Toosendan 3 grams, Fructus Piperis Longi 14 grams, 4 grams, Flos Carthami, Semen Cuscutae 12 grams, the Radix Linderae 3 grams, Indigo Naturalis 8 grams, Radix Arnebiae (Radix Lithospermi) 5 grams, Cortex Moutan 15 grams, Placenta Hominis 7 grams, Radix Polygalae 2 grams, the Radix Astragali 4 grams, Fructus Citri Sarcodactylis 19 grams, the Cortex Eucommiae 14 grams, Fructus Rubi 6 grams, Flos Rosae Rugosae 7 grams, Radix Puerariae 14 grams, Herba Taraxaci 9 grams, Periostracum Cicadae 6 grams, Herba Cistanches 17 grams, Herba Epimedii 13 grams, Caulis Polygoni Multiflori 10 grams, Cortex Magnoliae Officinalis 4 grams, Herba Artemisiae Scopariae 4 grams.

Preparation method is with embodiment 1.

Clinical data:

Wang, female, 23 years old, Laoshan people.Patient's private prosecution: menstruation irregularis, dysmenorrhea, once repeatedly treated, but poor effect.Be diagnosed as: endocrine disturbance.Take tablet of the present invention after menstruation one day three times, each three, sooner or later one after each meal, within 7 days, be a course for the treatment of, after 1 course for the treatment of, dysmenorrhea obviously alleviates, and continue to take 3 courses for the treatment of, dysmenorrhea disappears completely, menstruation rule, cures, and within 1 year subsequently, pays a return visit without recurrence.

Clinical reasoning:

In April ,-2015 in January, 2014, the routine clinical observation of female endocrine dyscrasia patient 90 of making a definite diagnosis is randomly drawed in outpatient service place, and patient is divided into two groups at random, treatment group 45 example, age 18-40 year, 27.1 years old mean age; Matched group 45 example, age 21-42 year, 29.3 years old mean age.The degrees of symptoms of two groups of cases is basically identical, without significant difference, has comparability.

Diagnostic criteria: the diagnostic criteria according to endocrine disturbance in People's Republic of China's traditional Chinese medicine industry standard " disease of tcm Standardization of diagnosis and curative effect ":

1. emotional factor: the variation occurring emotion emergentness, often wants to fly into a rage;

2. external feature: mottle appears in face, skin conditions worsens;

3. infertile for a long time: endocrine regulation can affect estrogenic secretion, causes female acyesis;

4. poliosis senilism: seem excessive aging, and actual age is not inconsistent, alopecia senilism.

Therapeutic Method:

Treatment group: patient takes the tablet of the embodiment of the present invention 2, sooner or later take at twice, each 27 days is 1 course for the treatment of, treats 2-3 the course for the treatment of altogether.

Matched group: patient takes the regulating menstruation clever sheet of benefit (Xian Renren Phar. Co., Ltd., the accurate word of traditional Chinese medicines: Z20003277), sooner or later respectively taking 4,7 days is 1 course for the treatment of, treats 2-3 the course for the treatment of altogether.

Curative effect determinate standard:

(1) cure: clinical symptom disappearance, sign is normal, without recurring after following up a case by regular visits to half a year;

(2) effective: clinical symptom relief, sign takes a turn for the better to some extent;

(3) effective: clinical symptoms alleviates to some extent, and sign is without being clearly better;

(4) invalid: clinical symptoms is without improvement, and sign is without improvement.

Clinical efficacy comparison, the results are shown in Table 1.

Table 1 liang group patient effective percentage relative analysis

Group

Number of cases

Cure

Effective

Effectively

Invalid

Effectively total

Treatment group

45

27(60％)

11(24.4％)

5(11.1％)

2(4.4％)

43(95.6％)

Matched group

45

14(31.1％)

11(24.4％)

7(15.6％)

13(28.9％)

32(71.1％)

Wherein, total effective rate=cure rate+obvious effective rate.

Table 1 result shows: tablet total effective rate prepared by the embodiment of the present invention 2 is 95.6%; matched group total effective rate 71.1%; result shows, illustrates that medicine of the present invention achieves better therapeutic effect than traditional therapy in curative effect, is suitable for scale clinical practice.

Last it is noted that above embodiment is only in order to illustrate technical scheme of the present invention, be not intended to limit; Although with reference to previous embodiment to invention has been detailed description, those of ordinary skill in the art is to be understood that: it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature; And these amendments or replacement, do not make the essence of appropriate technical solution depart from the scope of various embodiments of the present invention technical scheme.

Claims (6)

1. treat a Chinese medicine composition for female endocrine dyscrasia, it is characterized in that: the crude drug of described Chinese medicine composition is made up of Fructus Ligustri Lucidi, Radix Polygoni Multiflori, Herba Leonuri, Caulis Spatholobi, Caulis Bambusae In Taenia, Radix Notoginseng, Folium Isatidis, Folium Ginkgo, Semen Coicis, Herba Dendrobii, Pericarpium Citri Reticulatae Viride, Fructus Toosendan, Fructus Piperis Longi, Flos Carthami, Semen Cuscutae, the Radix Linderae, Indigo Naturalis, Radix Arnebiae (Radix Lithospermi), Cortex Moutan, Placenta Hominis, Radix Polygalae, the Radix Astragali, Fructus Citri Sarcodactylis, the Cortex Eucommiae, Fructus Rubi, Flos Rosae Rugosae, Radix Puerariae, Herba Taraxaci, Periostracum Cicadae, Herba Cistanches, Herba Epimedii, Caulis Polygoni Multiflori, Cortex Magnoliae Officinalis, Herba Artemisiae Scopariae.

2. the Chinese medicine composition for the treatment of female endocrine dyscrasia according to claim 1, it is characterized in that: crude drug composition and the parts by weight of making described Chinese medicine composition are: Fructus Ligustri Lucidi 11-14 part, Radix Polygoni Multiflori 9-15 part, Herba Leonuri 3-6 part, Caulis Spatholobi 8-13 part, Caulis Bambusae In Taenia 3-5 part, Radix Notoginseng 1-3 part, Folium Isatidis 5-10 part, Folium Ginkgo 5-10 part, Semen Coicis 3-10 part, Herba Dendrobii 8-13 part, Pericarpium Citri Reticulatae Viride 3-5 part, Fructus Toosendan 1-3 part, Fructus Piperis Longi 9-15 part, Flos Carthami 3-7 part, Semen Cuscutae 8-13 part, Radix Linderae 3-6 part, Indigo Naturalis 8-13 part, Radix Arnebiae (Radix Lithospermi) 3-5 part, Cortex Moutan 11-15 part, Placenta Hominis 5-10 part, Radix Polygalae 2-5 part, Radix Astragali 4-9 part, Fructus Citri Sarcodactylis 12-20 part, Cortex Eucommiae 10-16 part, Fructus Rubi 3-8 part, Flos Rosae Rugosae 5-12 part, Radix Puerariae 12-17 part, Herba Taraxaci 7-12 part, Periostracum Cicadae 4-9 part, Herba Cistanches 15-20 part, Herba Epimedii 10-15 part, Caulis Polygoni Multiflori 8-12 part, Cortex Magnoliae Officinalis 2-5 part, Herba Artemisiae Scopariae 3-7 part.

3. the Chinese medicine composition for the treatment of female endocrine dyscrasia according to claim 2, is characterized in that: described Chinese medicine composition is prepared according to following method:

(1) pulverized by pulverizer after each crude drug of described components by weight percent proportionally being mixed, be ground into 100 order ~ 200 object powder, adding determining alcohol is 85% ~ 90% alcohol reflux 2.5 ~ 4 hours, the ethanol quality added is 3.5 ~ 5 times of mixture quality, filter, obtain filtering liquid medicine, the extractum of 1.3-1.4 when concentrating under reduced pressure becomes relative density to be 80 DEG C, heating is concentrated into paste, stand for standby use;

(2) medicinal residues that ethanol extraction in step (1) is crossed are put into 10-12 times of water gaging, then put into extraction pot heated and boiled 1.5-2 hour, filter, filtrate is for subsequent use; Filtering residue adds water, and second time heating, boils 45 minutes, and filter, filtrate is for subsequent use;

(3) 2 filtrates in step (2) be combined, by filtered through gauze, add 50-60% ethanol in residue, 60 DEG C-70 DEG C are continued lixiviate 2-3h, and every 10min stirs once, filtered through gauze, merge lixiviating solution, are condensed into pasty state;

(4) the pastel decompression recycling ethanol concentrated for step (1) paste that obtains and step (3) obtained also is concentrated into 1.15-1.20 when relative density is about 20 DEG C, centrifugal under the rotating speed of 3000r/min, at 60 DEG C of-80 DEG C of spraying dry, obtain dry extract;

(5) dry extract obtained for step (4) is placed in super micron mill pulverizes 1.5-2 hour, pulverize, sieve, obtain 350-400 object micropowders;

(6) micropowders that step (5) is obtained is added appropriate micropowder silica gel, α-galactose mixing, take ethanol as wetting agent, granulate, dry, granulate, encapsulated, obtained capsule.

4. the Chinese medicine composition for the treatment of female endocrine dyscrasia according to claim 2, is characterized in that: described Chinese medicine composition is prepared according to following method:

(1) pulverized by pulverizer after each crude drug of described components by weight percent proportionally being mixed, be ground into 100 order ~ 200 object powder, adding determining alcohol is 85% ~ 90% alcohol reflux 2.5 ~ 4 hours, the ethanol quality added is 3.5 ~ 5 times of mixture quality, filter, obtain filtering liquid medicine, the extractum of 1.3-1.4 when concentrating under reduced pressure becomes relative density to be 80 DEG C, heating is concentrated into paste, stand for standby use;

(2) medicinal residues that ethanol extraction in step (1) is crossed are put into 10-12 times of water gaging, then put into extraction pot heated and boiled 1.5-2 hour, filter, filtrate is for subsequent use; Filtering residue adds water, and second time heating, boils 45 minutes, and filter, filtrate is for subsequent use;

(3) 2 filtrates in step (2) be combined, by filtered through gauze, add 50-60% ethanol in residue, 60 DEG C-70 DEG C are continued lixiviate 2-3h, and every 10min stirs once, filtered through gauze, merge lixiviating solution, are condensed into pasty state;

(4) the pastel decompression recycling ethanol concentrated for step (1) paste that obtains and step (3) obtained also is concentrated into 1.15-1.20 when relative density is about 20 DEG C, centrifugal under the rotating speed of 3000r/min, at 60 DEG C of-80 DEG C of spraying dry, obtain dry extract;

(5) dry extract obtained for step (4) is placed in super micron mill pulverizes 1.5-2 hour, pulverize, sieve, obtain 350-400 object micropowders;

(6) micropowders that step (5) is obtained is added suitable amount of sucrose, dextrin mixing, take ethanol as wetting agent, granulate, dry, granulate, tabletting, obtained tablet.

5. the Chinese medicine composition for the treatment of female endocrine dyscrasia according to claim 2, is characterized in that: described Chinese medicine composition is prepared according to following method:

(1) pulverized by pulverizer after each crude drug of described components by weight percent proportionally being mixed, be ground into 100 order ~ 200 object powder, adding determining alcohol is 85% ~ 90% alcohol reflux 2.5 ~ 4 hours, the ethanol quality added is 3.5 ~ 5 times of mixture quality, filter, obtain filtering liquid medicine, the extractum of 1.3-1.4 when concentrating under reduced pressure becomes relative density to be 80 DEG C, heating is concentrated into paste, stand for standby use;

(2) medicinal residues that ethanol extraction in step (1) is crossed are put into 10-12 times of water gaging, then put into extraction pot heated and boiled 1.5-2 hour, filter, filtrate is for subsequent use; Filtering residue adds water, and second time heating, boils 45 minutes, and filter, filtrate is for subsequent use;

(3) 2 filtrates in step (2) be combined, by filtered through gauze, add 50-60% ethanol in residue, 60 DEG C-70 DEG C are continued lixiviate 2-3h, and every 10min stirs once, filtered through gauze, merge lixiviating solution, are condensed into pasty state;

(4) the pastel decompression recycling ethanol concentrated for step (1) paste that obtains and step (3) obtained also is concentrated into 1.15-1.20 when relative density is about 20 DEG C, centrifugal under the rotating speed of 3000r/min, at 60 DEG C of-80 DEG C of spraying dry, obtain dry extract;

(5) dry extract obtained for step (4) is placed in super micron mill pulverizes 1.5-2 hour, pulverize, sieve, obtain 350-400 object micropowders;

(6), after the micropowders that step (5) is obtained being added suitable amount of sucrose, dextrin mixing, take ethanol as wetting agent, granulate, dry, granulate, obtained granule.

6. the application of Chinese medicine composition in treatment female endocrine dyscrasia medicine of the treatment female endocrine dyscrasia as described in as arbitrary in claim 1-5.