CN105307601A - Auxiliary small vasculature guidewire - Google Patents
Auxiliary small vasculature guidewire Download PDFInfo
- Publication number
- CN105307601A CN105307601A CN201480015085.9A CN201480015085A CN105307601A CN 105307601 A CN105307601 A CN 105307601A CN 201480015085 A CN201480015085 A CN 201480015085A CN 105307601 A CN105307601 A CN 105307601A
- Authority
- CN
- China
- Prior art keywords
- pilot line
- supplemental pilot
- guide wire
- electroactive polymer
- supplemental
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
- A61M25/09—Guide wires
- A61M25/0905—Guide wires extendable, e.g. mechanisms for extension
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
- A61M25/09—Guide wires
- A61M2025/09133—Guide wires having specific material compositions or coatings; Materials with specific mechanical behaviours, e.g. stiffness, strength to transmit torque
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
- A61M25/09—Guide wires
- A61M2025/0915—Guide wires having features for changing the stiffness
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention generally relates to an auxiliary guidewire for an intravascular procedure. The invention provides an auxiliary guidewire that slips over a primary guidewire and can provide a very fine extension beyond the end of the primary guidewire. The primary guidewire can be taken to its limit within the fine vasculature, and the auxiliary guidewire can then extend further into the fine vasculature. The primary guidewire can be taken to a bifurcation. The primary guidewire and the auxiliary guidewire can be sent down separate branches of the bifurcation. A physician can select which of the primary guidewire and the auxiliary guidewire are within the branch that needs to be treated by, for example, consulting an angiography display.
Description
Cross reference related application
This application claims interests and the priority of the U.S. Provisional Patent Application 61/783,023 that on March 14th, 2013 submits to, its content is incorporated to herein by reference.
Technical field
The present invention relates generally to the supplemental pilot line for endovascular surgeries, works together with the guide wire for endovascular surgeries.
Background technology
Because fatty speckle accumulates the flowing limiting blood in some tremulous pulsies, or interrupt and block the flowing of blood even completely, they are in the risk of heart disease or apoplectic seizure.Angioplasty is a kind of operation being used for the treatment of the position affected by speckle.In this operation, with the skin formation opening of pin through patient.Subsequently guide wire be inserted through this opening and be directed through tremulous pulse until affected position.Doctor attempts guiding this guide wire by twisting and handling the near-end be positioned at outside patient.
Guide wire is intended in many therapeutic choice helpful.Such as, (such as, with ultrasonic or optical imaging sensor) imaging guide wire may be used for making affected position visual.If affected blood vessel seriously narrows due to speckle accumulation, guide wire may be used for, via conduit, air bag or support are transported to affected position, to opening the blood vessel narrowed.If affected position blocks completely, guide wire or special instrument may be used for cutting blocking.
Many problems are performed the operation relevant to these.Such as, may block in the vascular system that the guide wire for standard is too very thin.Enough very thin and the guide wire of such blood vessel can be reached may be too soft and can not use.The blood vessel of branch it is also proposed a difficult problem for guiding.It may be difficult for line being guided into correct branch.
Summary of the invention
The invention provides a kind of supplemental pilot line, it slides and can provide the very very thin extension exceeding leading wire ends on leading lead-in wire.Leading lead-in wire can be taken to its limit in very thin vascular system, and supplemental pilot line can extend much further into very thin vascular system subsequently.Leading lead-in wire can be brought to bifurcated.Leading lead-in wire and supplemental pilot line can send downwards along the branch separated of bifurcated.Doctor can needed in the branch for the treatment of by which such as checking that angiography display selects in leading lead-in wire and supplemental pilot line.Another guide wire can be removed, and by conduit, treatment can be transported to the correct branch of bifurcated.Supplemental pilot line is slided on leading lead-in wire by sleeve part.In certain embodiments, sleeve part can by such as comprising electroactive polymer to fluff at sleeve part or tightening up.This allows supplemental pilot line or moves forward together with leading lead-in wire, or moves forward relative to leading lead-in wire.Use supplemental pilot line as the very very thin extension of leading lead-in wire therefore to the instrument that doctor leads in the vascular system that patient is very very thin.Treated with the irremediable fatty speckle of other mode.
In some aspects, the invention provides supplemental pilot line, comprise at least one sleeve part arranged along ennation.Preferably, sleeve part limits the opening area of about 0.014 inch.Preferably, supplemental pilot line is sub-0.014 inch of supplemental pilot line.Sleeve part can comprise the electroactive polymer of at least one part.Supplemental pilot line can comprise multiple sleeve part.Sleeve part can comprise the portion of reaming.
Each aspect of the present invention is provided for the system for the treatment of very thin vascular system, and this system comprises: guide wire, conduit and supplemental pilot line.Preferably, guide wire is standard 0.014 inch of guide wire.And supplemental pilot line comprises at least one sleeve part arranged along ennation, sleeve part has the opening area of about 0.014 inch.Preferably, supplemental pilot line is sub-0.014 inch of supplemental pilot line.Sleeve part can comprise the electroactive polymer of at least one part.
In related fields, the invention provides method conduit being inserted branch selected by bifurcated.The method is included in this bifurcated of the upper observation of angiography display.Identify that the selection branch of this bifurcated is for treatment.Insert guide wire until this bifurcated.Supplemental pilot line slides on guide wire, and is brought to this branch.This supplemental pilot line is sent downwards along a branch, this guide wire is sent downwards along another branch.By which in this supplemental pilot line of angiography Identification display and this guide wire in this selection branch.Remove in this supplemental pilot line and this guide wire another.Conduit is transported to this selection branch.
Accompanying drawing explanation
Fig. 1 shows the conduit with guide wire.
Fig. 2 shows guide wire.
Fig. 3 shows supplemental pilot line of the present invention.
Fig. 4 illustrates the system comprising supplemental pilot line.
Fig. 5 shows and the sleeve pipe of supplemental pilot line reams portion.
Fig. 6 presents and supplemental pilot line reams portion.
Fig. 7 depicts and uses supplemental pilot line to enter very thin vascular system.
Fig. 8 shows and uses system of the present invention to select the bifurcated of bifurcated.
Detailed description of the invention
The invention provides a kind of supplemental pilot line for endovascular surgeries, it comprises along supplemental pilot line at one or more sleeve pipe of one or more position or ream portion's (such as, being made up of electroactive polymer).Preferably, supplemental pilot line is sub-0.014 inch of guide wire, and can be inserted on standard (such as 0.014 inch) guide wire and to slide along it.Guide wire, supplemental pilot line or they both can be used in endovascular surgeries, such as cross chronic completely blocking or in coronary angioplasty, carry air bag or support.
Fig. 1 shows conduit 101, and guide wire 201 arranges through wherein.Conduit 101 mainly comprises the nearly portion 103 extending to distal part 111.Optionally, such as the therapeutic equipment such as air bag or support 105 can be located near tip 109 far away.
Fig. 2 shows the nearly portion 213 that comprises and extend to distal part 209 and ends at the guide wire 201 of end 205 far away.Preferably, guide wire 201 is standard 0.014 inch of guide wire.
Fig. 3 shows the distal part of supplemental pilot line 301.Supplemental pilot line 301 can have any suitable shape of cross section, such as, and such as circle, pancake, ellipse or kidney-shaped cross section.Supplemental pilot line can comprise one or more sleeve pipe 305, and being sized to of sleeve pipe 305 can be slided on guide wire 201.Sleeve part 305 can comprise electroactive polymer.Preferably, supplemental pilot line 301 is sub-0.014 inch of guide wire, and can by using one or more sleeve part 305 at proximal slide on standard guide wire 201.
Fig. 4 shows the supplemental pilot line 301 being coupled to guide wire 201.
Fig. 5 depicts interchangeable embodiment, and wherein sleeve part 305 comprises the portion of reaming 309.Comprise the portion of reaming 309 and can provide inclined-plane for guiding enters very thin vascular system, this is useful.In addition, it is useful for comprising the portion of reaming 309 by increasing the area entering the perforate of sleeve pipe 305, makes supplemental pilot line 301 to be coupled to guide wire 201 and becomes and more easily realize.
Fig. 6 depicts embodiment, and wherein supplemental pilot line 301 supporting ends at the prolongation tube chamber in the portion of reaming 309.When hope keep supplemental pilot line 301 fully against guide wire 201, the present embodiment can be preferred.
In certain embodiments, supplemental pilot line 301 comprises the electroactive polymer of at least one part.In certain embodiments, sleeve part 305 comprises the electroactive polymer of at least one part.Electroactive polymer can cause sleeve pipe 305 to be out of shape (such as contraction or expansion) when being energized.Therefore can expansion sleeve pipe fitting 305, allow to insert and slide on guide wire 201.Can retract or limiting boot part 305, so that supplemental pilot line 301 is fixed on guide wire 201.In addition, after removing guide wire 201, can retract or limit electroactive polymer to reduce sleeve part 305.Reducing sleeve part 305 allows conduit 101 to pass through on supplemental pilot line 201.
Electroactive polymer is out of shape when there is extra electric field, the spitting image of piezo-activator.EAP produces power, strain, deflection or their combination.Usually, the type of EAP comprise ion, electrolyte and composite.Ion EAP carrys out work by ion movement in the polymer.Ion EAP has the coupling power of biological muscles and the potentiality of energy density.Ionic polymers-metallic composite (IPMC) is in response to as ambulant being electrically excited of result of cation in polymer network and the electroactive polymer bent.Usually, adopt the base polymer of two types to form IPMC, the perfluorocarboxylic acid ester of the trade mark that such as Du Pont sells to be trade mark that the perfluorinated sulfonic acid ester of NAFION and Japanese AsahiGlass sell be FLEMION.IPMC requires the low voltage (1-10V) exciting bending response under lower than the low frequency of 1Hz.
Some crystal (such as quartz, tourmaline and Rochelle salt) producing voltage in some axis compression on plane of crystal.The effect of reverse side is also presented, and the applying of electric current makes crystal modification thus.Any suitable electroactive material is includable.Suitable material comprises poly-(vinylidene fluoride) or PVDF and copolymer thereof.These materials comprise the partially crystallizable composition being in non-activity amorphous phase.The AC field (~ 200MV/m) applied causes electrostriction (non-linear) strain of about 2%.P (VDF-TrFE) is that one shows the PVDF polymer of Electrostrictive strain up to 5% through electron radiation at low frequency driving field (150V/mm).
Can adopt electrostatic field to the polymer that those present low elasticity rigidity and high dielectric constant, to cause large actuation strain, these polymer are called as electrostatic electrostrictive polymer (ESSP) actuator.
Ferroelectric electroactive polymer actuator can carry out work in air, vacuum or water in whole wide temperature range.
Electricity dielectric living polymer is elastomer capacitor in essence.Electrostatic force causes charged electrode compression intermediate polymer layer, causes such as along the strain-responsive expanded in the direction orthogonal with compression.This process is also reversible, and it may be used for producing electric power or being used as sensor (the spitting image of piezoelectrics).Electricity dielectric living polymer forms the basis of electroactive polymer artificial-muscle (EPAM) " spring volume " actuator.Electricity dielectric electroactive polymer actuator can use large electric field (~ 100V/mm) and can produce level of strain (10-200%).Acrylic elastomer band, the trade mark that such as 3M sells is the band of VHB, can have the plane strain more than 300% for twin shaft symmetry constraint, can have the linear strain of nearly 215% for single shaft constraint.
Electrostriction is transplanted elastomer and is comprised two compositions, flexible macromolecule main chain and the transplanting polymer that can produce in crystalline form.This material presents high strain (~ 4%), combined machine power and outstanding processing characteristics.In certain embodiments, the present invention utilizes poly-(vinylidene fluoride-trifluoro-ethylene) copolymer of piezoelectricity to provide electrostriction to transplant elastomer.This combination has the ability of the ferroelectric-electrostrictive molecular composite systems of the amount of changing.These can as piezoelectric transducer or or even electrostrictive actuator carry out work.
Embodiments of the invention can comprise electric viscoelastic elastomers, and it comprises silicone elastomer and polarity phase.When solidifying, apply electric field, it makes polarity mutually directed in elastomer array.The electric field (<6V/mm) applied causes the change of modulus of shearing.
Liquid crystal elastic body (LCE) material has electroactive polymer characteristic by causing Joule heating.The composite that LCE is made up of single domain nematic liquid crystal elastomer and conducting polymer, it is distributed in their network structure.Actuating mechanism is the phase transformation between nematic phase and isotropic phase.Actuating occurred in the time less than one second.
Conducting polymer (CP) comprises this EAP, and it is by occurring in the insertion of the reversible counter ion counterionsl gegenions in redox cycle and ejecting actuating.By oxidation at respective electrode place of ion and electrolytical exchange and reduction reaction, there is significant change in volume.Conductive polymer actuator requires the voltage within the scope of 1-5V.The change of voltage can control actuation speed.20J/cm can be reached more than with these materials
3comparatively high mechanical energy metric density.Electrode for conducting polymer from polypyrrole or polyaniline or can obtain doped with the polyacrylonitrile (PAN) of HC1.Other combination of materials for conducting polymer is polypyrrole, polyethylene dioxythiophene, poly-(to phenylacetylene) class, polyaniline and polythiophene.
CNT (CNT) can change by electrolyte medium and bond distance the polymer activated, and the charge injection that bond distance changes by affecting the charge balancing ion between nanotube and electrolyte realizes.The electric charge injecting CNT is more, and size changes larger.Due to the mechanical strength of single CNT and modulus and attainable actuator displacement, these electroactive polymers can have the highest merit of each cycle, and produce much higher mechanical stress than the electroactive polymer of other form.
Comprise other character one or more that electroactive polymer may be used for affecting supplemental pilot line 301.Any character relevant with the change in size in response to applied electromotive force is includable.Exemplary character comprises variable rigidity, and variable rigidity is because the one or more diverse locations on supplemental pilot line 301 comprise electroactive polymer at least partially.
In certain embodiments, the actuating of electroactive polymer causes the region rigidity around electroactive polymer part to increase, and what increase supplemental pilot line 301 thus can promotion.Interchangeable, the actuating of the electroactive polymer of at least one part causes the region rigidity around this electroactive polymer part to reduce, and increases the flexibility of supplemental pilot line 301 thus.
In one embodiment, the electroactive polymer of this at least one part forms interior axle or a part for outer shaft for supplemental pilot line 301.In one embodiment, the electroactive polymer of this at least one part is longitudinal tape.In one embodiment, the axle of supplemental pilot line 301 is obtained by electroactive polymer.In one embodiment, the electroactive polymer of this at least one part forms the outer surface of interior axle.In one embodiment, the electroactive polymer of this at least one part is positioned at the tip of auxiliary conductor 301.
Due to the strategy orientation of electroactive polymer diverse location on guide wire of at least one part, electroactive polymer can provide a kind of ability bending or rotate, and such as, leads in vascular system.In one embodiment, the electroactive polymer of at least one part is only positioned at the side of axle, to control the deflection of tip far away.In one embodiment, the electroactive polymer of at least one part changes the spatial configuration of guide wire, to improve turning to around turning.In one embodiment, guide wire has the electroactive polymer of at least one part.In one embodiment, guide wire tip has the electroactive polymer of at least one part.In one embodiment, the electroactive polymer being in this at least one part of actuating state causes guide wire axial shrinkage.The action that can be presented by supplemental pilot line 301 comprise stretching or compression, axial-rotation (such as moment of torsion), oscillation crosswise, reciprocating motion (such as dragsaw or brush action) or any other action or their combination.
Except the guiding improved by comprising electroactive polymer, supplemental pilot line 301 relies on its minor diameter to present the guiding of improvement.Such as, supplemental pilot line 301 can insert the unaccommodated blood vessel of guide wire 201.
Fig. 7 illustrates the guiding advantage provided by supplemental pilot line 301.Insert guide wire 201 and provide path for following for supplemental pilot line 301.Compared with only using guide wire 201, supplemental pilot line 301 provide a kind of to vascular system more depths guiding mechanism.
The very thin vascular system guidance capability of supplemental pilot line 301 provides further guiding advantage in conjunction with the motility of the improvement of supplemental pilot line 301.Such as, owing to comprising at least one electroactive polymer, supplemental pilot line 301 can be rotated, to enter the branch of off-axis.
Further, supplemental pilot line 301 can at the point of the tip nearside far away of guide wire 201 from guide wire 201 bifurcated (such as supplemental pilot line 301 and guide wire 201 form " Y " shape).As a result, for the Liang Ge branch of bifurcated in blood vessel, doctor can lead and enter.
Fig. 8 illustrates the path using the guiding of supplemental pilot line 301 to enter the vascular system bifurcateds that self-conductance lead-in wire 301 is followed the trail of.This area all knows that guiding is the challenge of difficulty in bifurcated.See the people such as such as Suzuki, 2013, a kind of novel guide wire method for the treatment of acute angle bifurcated, JInvCardiol25 (l): 48-54; The people such as Lefevre, 2007, the stent endoprosthesis of bifurcated lesions, JIntervenCardiol14 (6): 573-585; And the people such as Oesterle, 2005, the angioplasty of coronary artery crotch, CathCardDiag12 (l): 57-63, in them, the content of each is incorporated to herein by reference.
When bifurcated vessels must be treated, the bifurcated shown in Fig. 8 may be obtained.Doctor can check the position (such as by angiography) of supplemental pilot line 301 and guide wire 201 subsequently and treatment conduit is delivered to which branch of bifurcated by decision.No matter doctor determines to treat which branch, and the guide wire of another branch corresponding can be removed subsequently.Therefore, supplemental pilot line 301 gives the ability selecting which branch conduit being delivered to bifurcated vessels.Bifurcated is discussed at the United States Patent (USP) 8,088,102 of Adams; The United States Patent (USP) 7,300,460 of Levine; The U.S. of Vardi discloses 2009/0326634; The U.S. of Vardi discloses 2001/0049548, and in them, the content of each is incorporated to herein by reference.
Such fact that curvature for supplemental pilot line 301 can cause from computer work (such as by mouse, stick or Computer key), supplemental pilot line 301 can be guided through or intravasation, even in the position of distortion or bifurcated.Such as, doctor can the display of reference vessel radiography.Angiography system by radiopaque contrast agent being injected blood vessel and using such as fluoroscopy etc. based on the technology imaging of X-ray, can make visualization of blood vessels.
Angiography comprises the imaging technique of projection radiography and such as CT angiography and MR angiography.In certain embodiments, angiography relate to use x-ray contrast agent and x-ray system make tremulous pulse and guide wire 201 visual.The radioscopic image of the instantaneous ray contrast distribution in the blood flowed in coronary artery allows the position of guide wire 201, especially relative to position visual of arterial ostium.
Doctor can with reference to angiography display to guide guide wire 201.Angioradiographic system and method are discussed at, such as, and United States Patent (USP) 7,734,009; United States Patent (USP) 7,564,949; United States Patent (USP) 6,520,677; United States Patent (USP) 5,848,121; United States Patent (USP) 5,346,689; United States Patent (USP) 5,266,302; United States Patent (USP) 4,432,370; Disclose in 2011/0301684 with the U.S., in them each content in order to various object by reference entirety be incorporated to herein.Useful conduit and guide wire are discussed at United States Patent (USP) 7, and 766,896 and United States Patent (USP) 7,909, in 844, their content is incorporated to herein by reference.
Supplemental pilot line 301 can comprise size adjustment mechanism, to regulate the circumferential size of guide wire.In the present embodiment, size adjustment mechanism can carry out work by a pair electroactive polymer actuator.Electroactive polymer actuator is configured to the experience deflection when activating, to regulate the circumferential size of guide wire.
Usually, supplemental pilot line 301 can comprise one or more electroactive polymer actuator, with the elastomer polymer be placed between pair of electrodes.Elastomer polymer layer can be configured to deflect when striding across elastomer polymer and applying pressure reduction.One or more during can to comprise in multiple polymers any number of of electroactive polymer actuator, such as, comprise electric Jie's electrostriction electroactive polymer, ion exchange electroactive polymer, ionic polymers-metallic composite electroactive polymer.For some embodiment, because their response time and work efficiency, electric Jie's electrostriction electroactive polymer is supposed to especially.The specific examples of operable polymer comprises NusilCF19-2186 (can obtain from NusilTechnology, Carpenteria, Calif.); Electricity Jie elastomer polymer; Silicone rubber; Silicone elastomer; Acrylic elastomer, such as VHB4910 acrylic elastomer (3M company can be derived from, St.Paul, Minn.); Silicone, such as DowCorningHS3 (can DowCorning be derived from, Wilmington, Del.); Fluorosilicone, such as DowCorning730 (can DowCorning be derived from, Wilmington, Del.); Acrylic polymer, the acrylic resin (3M company can be derived from, St.Paul, Minn.) in such as 4900VHB oleic series; Polyurethane; Thermoplastic elastomer (TPE); Comprise the copolymer of poly-(vinylidene fluoride); Contact adhesive; Fluoroelastomer; Comprise the polymer of silicone and acrylic resin, such as comprise silicone and acrylic acid copolymer, and comprise the polymer blend of silicone elastomer and acrylic elastomer; And the combination of two or more these polymer.Electroactive polymer is discussed at United States Patent (USP) 8, and 206,429; United States Patent (USP) 8,133,199; United States Patent (USP) 6,514,237; United States Patent (USP) 5,573,520; United States Patent (USP) 4,830; 023; The U.S. discloses 2012/0265268; Disclose 2007/0208276 with the U.S., its content is incorporated to herein by reference.The use of electroactive polymer is discussed at United States Patent (USP) 8,100,838 further; United States Patent (USP) 8,021,377; United States Patent (USP) 6,969,395; United States Patent (USP) 6,139,510; The U.S. discloses 2005/0165439; Disclose 2004/0220606 with the U.S., its content is incorporated to herein by reference.
In certain embodiments, the electroactive polymer of at least one part forms spiral around guide wire 301.Spiral can be, such as, and the electroactive polymer of single manifold electroactive polymer or a continuous part.In at least one embodiment, the electroactive polymer of multiple part is had to form overall spiral pattern.In at least one embodiment, the electroactive polymer of this at least one part extends in the whole length of guide wire substantially with spiral pattern.The electroactive polymer of spiral part can optionally be activated, and what be forced to cause supplemental pilot line 301 bends or stretch.Such as, supplemental pilot line 301 in place in the blood vessel and by use after, while guide wire is removed, supplemental pilot line may be in curved shape, and it may interfere with support such as in place.In at least one embodiment, selectable actuating will stop or prevent axle in the process of guide wire taking-up from keeping, adopt or maintaining the bending of blood vessel or shape.
As discussed herein, the actuating of electroactive polymer makes guide wire being improved around turning or turning to of turning round through during vascular system.
Supplemental pilot line 301 can be manufactured by the nylon wire that coextrusion on the wall of guiding bobbin is removable.After nylon wire is drawn out, the axle obtained can scribble electrically conductive ink to form electrode and to fill electroactive polymer by electropolymerization.Antielectrode can be guiding the electrically conductive ink on outside bobbin.Each axial component of electroactive polymer can be deposited in a part of the circumference of metal supplemental pilot line 301.Antielectrode can deposit or print on insulator, and it is positioned on supplemental pilot line 301, contrary with the part of electroactive polymer.The actuating of electroactive polymer part causes supplemental pilot line 301 to bend along a direction, and this direction is contrary with the part that electroactive polymer applies supplemental pilot line 301.Desirable, in use, the axial component of these electroactive polymers will allow doctor to control the direction of supplemental pilot line 301, and permission manipulates better in body cavity.
In at least one embodiment, supplemental pilot line 301 comprises the polymer heat-shrink tube be made up of polyester (PET).Can deposition on a pet film by electrically conductive ink (such as, but be not limited to from the silver-colored ink of Erconinc or bronze ink).Because the line of electrically conductive ink can make very very thin, multiple conductor lines can be printed along supplemental pilot line 301.In the position of electroactive polymer actuator, larger surface can be printed, and electroactive polymer is deposited.
Extraly or alternatively, electroactive polymer may be used for hardening or the selection part of non-sclerosis (such as, make soft) supplemental pilot line 301.Supplemental pilot line 301 can comprise the longitudinal band of the electroactive polymer of some circumferential registration around guiding bobbin.The many electroactive polymer bands being positioned at identical circumferential coordinate place can along the longitudinal length location of guiding bobbin.Accurate placement around the circumference of guiding bobbin is not crucial, as long as the band of electroactive polymer guides the zone location of the flexibility/stiffness of bobbin around the whole circumference of axle along desired control.Desirable, the actuating of the longitudinal band of electroactive polymer changes the rigidity of the guiding bobbin in electroactive polymer banded zone.Band may be used for the hardness of increase guide wire subsequently and reduces flexible.In one embodiment, longitudinal band size when activateding reduces, and reduces the hardness of guide wire and increase flexibility.In one embodiment, the longitudinal band of electroactive guide wire around the circumferential registration guiding bobbin, and extends to the remote area of guiding bobbin from the proximal end region of guiding bobbin.In addition, the quantity around the band of the electroactive polymer of the circumferential registration of guiding bobbin can change.Actuating mechanism mainly comprises electrode.The electrode of electroactive polymer different piece is separated from each other, therefore can accomplish the accurate actuating of electroactive polymer expectation part.The outer surface of the band of electroactive polymer can flush substantially with the outer surface of guiding bobbin.In certain embodiments, the band of electroactive polymer can form an only part for the wall of guiding bobbin, that is, the band of electroactive polymer does not have the thickness identical with the wall of guiding bobbin, and does not neither flush with the inner surface of axle with the outer surface of axle yet.
In certain embodiments, hard element such as hard polymer band joins layer of electroactive polymer to.If expect the guide wire 201 of more high rigidity, activate layer of electroactive polymer.The actuating of layer of electroactive polymer causes size on electroactive polymer volume to increase, and by the outwards movement of hard polymer band, to cause the hardness of guide wire 201 to increase, because hardness increases along with the biquadratic of size.Polymeric tapes can extend along the whole length of guide wire 201, or band can be placed in the specific region of the hardness of desired control guiding bobbin along the length of guide wire 201.Similar, layer of electroactive polymer can extend along the whole length of guide wire 201, or layer of electroactive polymer can be placed in the specific region of the hardness of desired control guiding bobbin along the length of guide wire 201.In one embodiment, guide wire has layer of electroactive polymer at least partially, with at least one the hard polymer band engaged.For the example of the suitable material of hard polymer band including, but not limited to polyamide, polyethylene (PE), Marlex high density polyethylene (HDPE), polyether-ether-ketone (PEEK), polyimides (PI) and Polyetherimide (PEI), liquid crystal polymer (LCP), acetal and any mixture thereof or compositions.Such as, polymer and actuator can be placed as the U.S. discloses as described in 2005/0165439.
The part of supplemental pilot line 301 of the present invention can by any suitable material and the electroactive polymer manufacture that can give desired characteristic.The example of suitable material including, but not limited to, such as polyformaldehyde (POM), polybutylene terephthalate (PBT), polyether block ester, polyether block amide (PEBA), fluorinated ethylene propylene (FEP) (FEP), polyethylene (PE), polypropylene (PP), polrvinyl chloride (PVC), polyurethane, politef (PTFE), polyethers-ether ketone (PEEK), polyimides, polyamide, polyphenylene sulfide (PPS), polyphenylene oxide (PPO), polysulfones, nylon, perfluor (propyl vinyl ether) (PFA), polyether ester, the polymer such as polymer/metal complex, or their mixture, blend or combination.An example of polyether block ester, can obtain with trade (brand) name ARNITEL, and the suitable example of of polyether block amide (PEBA) can obtain from ATOMCHEMPOLYMERS, Birdsboro, PA with trade mark PEBA.
Guide wire of the present invention activates by using electroactive polymer actuator, activates at least partly.Electroactive polymer is characterised in that they change the ability of shape in response to electric excitation.Electroactive polymer comprises electrical electroactive polymer and ionic electroactive polymer.Also piezoelectric can be adopted.The electrostrictive polymers that electrical electroactive polymer comprises ferroelectric electroactive polymer, electric dielectric living polymer, such as electrostriction transplant elastomer and electric viscoelastic elastomers, and liquid crystal elastic body material.
About the extraneous information of electroactive polymer actuator, their design is considered, and the material that wherein can adopt and composition, can at such as United States Patent (USP) 7,777399; United States Patent (USP) 6,258,052; United States Patent (USP) 6,249,076; United States Patent (USP) 6,139,510; United States Patent (USP) 5,693,015; United States Patent (USP) 5,120,308; The U.S. discloses 2006/0100694; Disclose in 2006/0074442 with the U.S. and find, each in them is complete to be by reference incorporated to herein.Further, the network of conducting polymer can also be adopted.Such as, known in electroactive polymer network pyrrole polymerization, such as poly-(vinyl chloride), poly-(vinyl alcohol), comprise small part sulfonic group or carboxylic ions functional group and can E.I.DuPontCo. be derived from, Inc. a kind of perfluorinated polymers of (Wilmington, DE).Electroactive polymer be also discussed at the U.S. disclose 2004/0143160 and the U.S. disclose 2004/0068161, its each content is incorporated to herein by reference.
As used in this article, unless otherwise, word "or" is meant to " with or or ", sometimes show for or be called "and/or".
be incorporated to way of reference
In this is open, does the reference of, periodical, book, paper, Web content open to alternative document such as patent, patent application, patent and has quoted.All these files are incorporated in order to all objects are complete by reference herein.
equivalent
To those skilled in the art, based on the complete content of presents, comprise the reference to the science quoted and patent documentation herein, except showing in this article except those and describing, various change of the present invention and its many further embodiment will be obvious.Protection theme herein comprises important information, citing and guide, and it goes for the practice of the present invention in its each embodiment and equivalent thereof.
Claims (12)
1. a supplemental pilot line, comprising:
Ennation; And
Along at least one sleeve part that this ennation is arranged.
2. supplemental pilot line as claimed in claim 1, wherein this sleeve part limits the opening diameter of about 0.014 inch.
3. supplemental pilot line as claimed in claim 1, wherein this supplemental pilot line is sub-0.014 inch of supplemental pilot line.
4. supplemental pilot line as claimed in claim 1, wherein this sleeve part comprises the electroactive polymer of at least one part.
5. supplemental pilot line as claimed in claim 1, also comprises multiple sleeve part.
6. supplemental pilot line as claimed in claim 1, wherein this sleeve part comprises the portion of reaming.
7. be used for the treatment of a system for very thin vascular system, this system comprises:
Guide wire;
Conduit, comprises the tube chamber through this conduit and makes this guide wire extend through this tube chamber; And
Supplemental pilot line, has the diameter less than the diameter of this guide wire, and extends beyond the far-end of this guide wire.
8. system as claimed in claim 7, wherein this guide wire is standard 0.014 inch of guide wire.
9. system as claimed in claim 8, wherein this supplemental pilot line comprises at least one sleeve part arranged along ennation, and this sleeve part has the opening area of about 0.014 inch.
10. system as claimed in claim 9, wherein this supplemental pilot line preferably sub-0.014 inch of supplemental pilot line.
11. systems as claimed in claim 10, wherein this sleeve part comprises the electroactive polymer of at least one part.
12. 1 kinds of methods conduit being inserted branch selected by bifurcated, the method comprises:
This bifurcated is observed in angiography display;
Identify that the selection branch of this bifurcated is for treatment;
Insert guide wire until this bifurcated;
Make supplemental pilot line in upper slip, and by this supplemental pilot tape to this branch;
This supplemental pilot line is sent downwards along a branch, this guide wire is sent downwards along another branch;
By which in this supplemental pilot line of angiography Identification display and this guide wire in this selection branch;
Remove in this supplemental pilot line and this guide wire another; And
Conduit is transported to this selection branch.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361783023P | 2013-03-14 | 2013-03-14 | |
| US61/783,023 | 2013-03-14 | ||
| PCT/US2014/027230 WO2014152340A1 (en) | 2013-03-14 | 2014-03-14 | Auxiliary small vasculature guidewire |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105307601A true CN105307601A (en) | 2016-02-03 |
| CN105307601B CN105307601B (en) | 2019-01-29 |
Family
ID=51530827
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201480015085.9A Active CN105307601B (en) | 2013-03-14 | 2014-03-14 | Assist thin vessels system guide wire |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20140276620A1 (en) |
| EP (1) | EP2967946B1 (en) |
| JP (1) | JP2016513542A (en) |
| CN (1) | CN105307601B (en) |
| WO (1) | WO2014152340A1 (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108601926A (en) * | 2016-02-05 | 2018-09-28 | 得克萨斯系统大学董事会 | Steerable intraluminal medical device |
| CN108653842A (en) * | 2018-05-30 | 2018-10-16 | 哈尔滨工业大学 | A kind of more receiving terminal wireless power transmissions auxiliary blood supply device of tape relay coil |
| CN108671298A (en) * | 2018-05-30 | 2018-10-19 | 哈尔滨工业大学 | A kind of wireless power transmission human body auxiliary blood supply device |
| CN108686274A (en) * | 2018-05-30 | 2018-10-23 | 哈尔滨工业大学 | A kind of more receiving terminal implantation type wireless electric energy transmission people's body auxiliary blood supply devices |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20160287178A1 (en) * | 2015-03-30 | 2016-10-06 | St. Jude Medical Coordination Center Bvba | Sensor guide wire having a proximal tube with improved torque performance and maintained low bending stiffness |
| US10250165B2 (en) * | 2015-05-27 | 2019-04-02 | Snu R&Db Foundation | High speed actuator including active stiffness controller and method of driving the same |
| US10271795B2 (en) * | 2015-06-12 | 2019-04-30 | C. R. Bard, Inc. | Systems and methods for confirmation of prior catheter tip placement |
| TR201902927T4 (en) | 2015-10-27 | 2019-03-21 | Koninklijke Philips Nv | Medical probe for ultrasound imaging. |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20010049548A1 (en) * | 1999-06-04 | 2001-12-06 | Gil Vardi | Bifurcation lesion stent delivery using multiple guidewires |
| US20020183763A1 (en) * | 2001-05-17 | 2002-12-05 | Callol Joseph R. | Stent and catheter assembly and method for treating bifurcations |
| US20060100694A1 (en) * | 2002-06-13 | 2006-05-11 | Oren Globerman | Guidewire system |
| US20070118052A1 (en) * | 2005-10-27 | 2007-05-24 | Cook Incorporated | Wire guide having distal coupling tip |
| US20070250036A1 (en) * | 2006-04-25 | 2007-10-25 | Boston Scientific Scimed, Inc. | Variable stiffness catheter assembly |
| US20080109061A1 (en) * | 2006-11-02 | 2008-05-08 | Boston Scientific Scimed, Inc. | Adjustable bifurcation catheter incorporating electroactive polymer and methods of making and using the same |
| US20100292614A1 (en) * | 2007-10-02 | 2010-11-18 | Cook Incorporated | Medical systems, devices and methods for coupling wire guides |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006149804A (en) * | 2004-11-30 | 2006-06-15 | Japan Lifeline Co Ltd | Medical guide wire |
| US7901367B2 (en) * | 2005-06-30 | 2011-03-08 | Cook Incorporated | Wire guide advancement system |
| US9005138B2 (en) * | 2005-08-25 | 2015-04-14 | Cook Medical Technologies Llc | Wire guide having distal coupling tip |
| US8876772B2 (en) * | 2005-11-16 | 2014-11-04 | Boston Scientific Scimed, Inc. | Variable stiffness shaft |
| CA2630215A1 (en) * | 2005-11-17 | 2007-05-24 | Micromuscle Ab | Medical devices and methods for their fabrication and use |
| US7811238B2 (en) * | 2006-01-13 | 2010-10-12 | Cook Incorporated | Wire guide having distal coupling tip |
| US7798980B2 (en) * | 2006-01-31 | 2010-09-21 | Cook Incorporated | Wire guide having distal coupling tip for attachment to a previously introduced wire guide |
| US7785275B2 (en) * | 2006-01-31 | 2010-08-31 | Cook Incorporated | Wire guide having distal coupling tip |
| US8414632B2 (en) * | 2006-03-06 | 2013-04-09 | Boston Scientific Scimed, Inc. | Adjustable catheter tip |
| US20080281229A1 (en) * | 2007-04-23 | 2008-11-13 | Juan Carlos Parodi | Guidewire with adjustable stiffness |
| US8133199B2 (en) * | 2008-08-27 | 2012-03-13 | Boston Scientific Scimed, Inc. | Electroactive polymer activation system for a medical device |
-
2014
- 2014-03-14 CN CN201480015085.9A patent/CN105307601B/en active Active
- 2014-03-14 WO PCT/US2014/027230 patent/WO2014152340A1/en active Application Filing
- 2014-03-14 JP JP2016502377A patent/JP2016513542A/en active Pending
- 2014-03-14 US US14/210,872 patent/US20140276620A1/en not_active Abandoned
- 2014-03-14 EP EP14770194.0A patent/EP2967946B1/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20010049548A1 (en) * | 1999-06-04 | 2001-12-06 | Gil Vardi | Bifurcation lesion stent delivery using multiple guidewires |
| US20020183763A1 (en) * | 2001-05-17 | 2002-12-05 | Callol Joseph R. | Stent and catheter assembly and method for treating bifurcations |
| US20060100694A1 (en) * | 2002-06-13 | 2006-05-11 | Oren Globerman | Guidewire system |
| US20070118052A1 (en) * | 2005-10-27 | 2007-05-24 | Cook Incorporated | Wire guide having distal coupling tip |
| US20070250036A1 (en) * | 2006-04-25 | 2007-10-25 | Boston Scientific Scimed, Inc. | Variable stiffness catheter assembly |
| US20080109061A1 (en) * | 2006-11-02 | 2008-05-08 | Boston Scientific Scimed, Inc. | Adjustable bifurcation catheter incorporating electroactive polymer and methods of making and using the same |
| US20100292614A1 (en) * | 2007-10-02 | 2010-11-18 | Cook Incorporated | Medical systems, devices and methods for coupling wire guides |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108601926A (en) * | 2016-02-05 | 2018-09-28 | 得克萨斯系统大学董事会 | Steerable intraluminal medical device |
| US10960182B2 (en) | 2016-02-05 | 2021-03-30 | Board Of Regents Of The University Of Texas System | Steerable intra-luminal medical device |
| US11850378B2 (en) | 2016-02-05 | 2023-12-26 | Board Of Regents Of The University Of Texas System | Steerable intra-luminal medical device |
| US11918766B2 (en) | 2016-02-05 | 2024-03-05 | Board Of Regents Of The University Of Texas System | Steerable intra-luminal medical device |
| CN108653842A (en) * | 2018-05-30 | 2018-10-16 | 哈尔滨工业大学 | A kind of more receiving terminal wireless power transmissions auxiliary blood supply device of tape relay coil |
| CN108671298A (en) * | 2018-05-30 | 2018-10-19 | 哈尔滨工业大学 | A kind of wireless power transmission human body auxiliary blood supply device |
| CN108686274A (en) * | 2018-05-30 | 2018-10-23 | 哈尔滨工业大学 | A kind of more receiving terminal implantation type wireless electric energy transmission people's body auxiliary blood supply devices |
| CN108671298B (en) * | 2018-05-30 | 2020-12-11 | 哈尔滨工业大学 | Human body auxiliary blood supply device adopting wireless power transmission |
| CN108686274B (en) * | 2018-05-30 | 2020-12-11 | 哈尔滨工业大学 | Multi-receiving-end implanted wireless electric energy transmission human body auxiliary blood supply device |
| CN108653842B (en) * | 2018-05-30 | 2020-12-11 | 哈尔滨工业大学 | Multi-receiving-end wireless power transmission auxiliary blood supply device with relay coil |
Also Published As
| Publication number | Publication date |
|---|---|
| US20140276620A1 (en) | 2014-09-18 |
| CN105307601B (en) | 2019-01-29 |
| EP2967946A4 (en) | 2016-11-16 |
| JP2016513542A (en) | 2016-05-16 |
| EP2967946A1 (en) | 2016-01-20 |
| EP2967946B1 (en) | 2023-03-01 |
| WO2014152340A1 (en) | 2014-09-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105307601A (en) | Auxiliary small vasculature guidewire | |
| US20140180089A1 (en) | System and method for guidewire control | |
| US11850378B2 (en) | Steerable intra-luminal medical device | |
| US8414632B2 (en) | Adjustable catheter tip | |
| US9504804B2 (en) | Variable stiffness shaft | |
| US7766896B2 (en) | Variable stiffness catheter assembly | |
| EP3548131B1 (en) | Steerable medical device and the preparing method thereof | |
| US7909844B2 (en) | Catheters having actuatable lumen assemblies | |
| JP4481826B2 (en) | Thrombolysis catheter | |
| US10925688B2 (en) | Auxiliary small vasculature guidewire | |
| CN102781338A (en) | Improved Catheter | |
| RU2650583C2 (en) | Catheter having flat beam deflection tip with fiber puller members | |
| EP4461200A2 (en) | Steerable medical device and the preparing method thereof | |
| EP4461201A2 (en) | Steerable medical device and the preparing method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CP01 | Change in the name or title of a patent holder | ||
| CP01 | Change in the name or title of a patent holder |
Address after: California, USA Patentee after: Philips image guided therapy Co. Address before: California, USA Patentee before: VOLCANO Corp. |