CN105287310A - Compound with wrinkle removing function and application of compound - Google Patents
Compound with wrinkle removing function and application of compound Download PDFInfo
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- CN105287310A CN105287310A CN201510859743.9A CN201510859743A CN105287310A CN 105287310 A CN105287310 A CN 105287310A CN 201510859743 A CN201510859743 A CN 201510859743A CN 105287310 A CN105287310 A CN 105287310A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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Abstract
The invention discloses a compound with a wrinkle removing function. The compound comprises triterpenoid saponin and triterpene acid, wherein the triterpenoid saponin and the triterpene acid are active ingredients from centella. The triterpenoid saponin comprises one or two of asiaticoside and hydroxy asiaticoside, and the triterpene acid comprises one or two of asiatic acid and madasiatic acid. By compounding any one or two of the triterpenoid saponin with any one or two of the triterpene acid, human skin fibroblast secretes type I collagen, and the like can be remarkably improved, the obvious effect of aging skin regeneration is realized, and the compound can be used for the development of wrinkle removing cosmetics.
Description
Technical field
The present invention relates to biological technical field, particularly relate to a kind of complex and the application thereof with wrinkle removal function.
Background technology
Herba Centellae CentellaasiaticaL. is Umbelliferae Centella plant, and another name collapses jorum, Herba Calthae Membranaceae, Gotu Kola, tiger grass etc.There is the use history of more than 2,000 year in China, be mainly used in the diseases such as clearing away heat-damp and promoting diuresis, subduing swelling and detoxicating, jaundice due to damp-heat, carbuncle sore tumefacting virus, traumatic injury.Modern pharmacology research shows, Herba Centellae extract has stronger Central nervous depressant and anti-gastric-ulcer, anticancer, antiinflammatory, hypermnesis, improves cardiovascular and cerebrovascular vessel, promotes the multiple pharmacological effect such as wound healing.Chief active thing in Herba Centellae is the asiaticoside, asiaticoside etc. of triterpene saponin, has and promotes skin flbroblast secretion collagen protein.Triterpene saponin (asiaticoside, asiaticoside) in Herba Centellae, because it is in the effect promoting skin flbroblast secretion collagen protein, more and more receives publicity, and has started to be applied in cosmetics.
And the triterpenic acid also containing unusual low content in Herba Centellae, triterpenic acid (asiatic acid and Madecassic acid etc.) be triterpene saponin through the method such as enzyme or acidolysis, after removing glycosyl completely, the relevant aglycone of generation.Triterpenic acid, in the product development of cosmetics, is used for the exploitation of whitening function skin care item.But also unexposedly up to now cross triterpene saponin and triterpenic acid compound in Herba Centellae, for the purposes that aging skin is repaired.
Summary of the invention
The technical problem that the present invention mainly solves is to provide a kind of complex and the application thereof with wrinkle removal function, and this complex can significantly improve the effect promoting skin flbroblast secretion collagen protein, can be applied in Wrinkle removing cosmetic.
For solving the problems of the technologies described above, the technical scheme that the present invention adopts is: provide a kind of complex with wrinkle removal function, comprise triterpene saponin and triterpenic acid, described triterpene saponin and described triterpenic acid are the active component derived from Herba Centellae.
In a preferred embodiment of the present invention, described triterpene saponin is one or both in asiaticoside, asiaticoside.
In a preferred embodiment of the present invention, described triterpenic acid is one or both in asiatic acid, Madecassic acid.
In a preferred embodiment of the present invention, the application of described complex in Wrinkle removing cosmetic.
In a preferred embodiment of the present invention, in described Wrinkle removing cosmetic, the mass content of the triterpene saponin in complex is 0.001-10%, and the mass content of triterpenic acid is 0.001-10%.
In a preferred embodiment of the present invention, described Wrinkle removing cosmetic comprises described complex and other functional active components.
In a preferred embodiment of the present invention, the component of described wrinkle removal frost is: by percentage to the quality, glycerol 6.0%, butanediol 3.0%, 1, 2-pentanediol 2.0%, EDETATE SODIUM 0.1%, PEG-100 stearate 1.5%, glyceryl stearate 0.5%, caprylic/capric/myristic acid/glycerol stearate three ester 6.0%, Cholesteryl hydroxystearate 1.0%, spermol 2.0%, Butyrospermum parkii fruit fat 2.0%, behenyl alcohol 0.5%, polydimethylsiloxane 1.0%, cholesterol 0.2%, xanthan gum 0.3%, hyaluronate sodium 0.05%, phenoxyethanol 0.3%, methyl hydroxybenzoate 0.2%, ethyl hydroxybenzoate 0.1%, essence 0.1%, complex 0.1%, deionized water polishing to 100%, in wherein said complex, the mass ratio of triterpene saponin and triterpenic acid is 3:1.
In a preferred embodiment of the present invention, the component of described wrinkle removal emulsion is: by percentage to the quality, glycerol 6.0%, butanediol 5.0%, 1, 2-pentanediol 2.5%, EDETATE SODIUM 0.1%, Natrulon H-10 stearate 1.0%, Natrulon H-10 distearate 0.5%, glyceryl stearate 0.5%, dimethyl siloxane 1.0%, stearic acid 0.5%, hydrolecithin 0.2%, hyaluronate sodium 0.05%, xanthan gum 0.3%, phenoxyethanol 0.3%, methyl hydroxybenzoate 0.2%, ethyl hydroxybenzoate 0.1%, essence 0.1%, complex 0.2%, deionized water polishing to 100%, in wherein said complex, the mass ratio of triterpene saponin and triterpenic acid is 5:1.
In a preferred embodiment of the present invention, the component of described wrinkle removal essence is: by percentage to the quality, glycerol 6.0%, butanediol 3.0%, 1, 2-pentanediol 2.0%, EDETATE SODIUM 0.1%, hydrolecithin 0.5%, Natrulon H-10 oleate 0.3%, caprylic/capric/myristic acid/glycerol stearate three ester 1.0%, Cholesteryl hydroxystearate 0.5%, squalane 1.0%, dipentaerythritol hexahydroxystearic acid ester/six stearate/six rosinate 0.5%, cholesterol 0.2%, polymethylsilsesquioxane 1.0%, polydimethylsiloxane 1.0%, xanthan gum 0.3%, hyaluronate sodium 0.03%, phenoxyethanol 0.3%, methyl hydroxybenzoate 0.2%, ethyl hydroxybenzoate 0.1%, essence 0.05%, complex 0.05%, deionized water polishing to 100%, in wherein said complex, the mass ratio of triterpene saponin and triterpenic acid is 2:1.
The invention has the beneficial effects as follows: complex and the application thereof with wrinkle removal function of the present invention, complex is that triterpene saponin and triterpenic acid are carried out composite use, compare when being used alone triterpene saponin or triterpenic acid, the effect promoting human skin fibroblast secretion I-type collagen etc. can be significantly improved, there is the repair significantly promoting aging skin, can be applicable in the exploitation of Wrinkle removing cosmetic.
Detailed description of the invention
Be clearly and completely described to the technical scheme in the embodiment of the present invention below, obviously, described embodiment is only a part of embodiment of the present invention, instead of whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art, not making other embodiments all obtained under creative work prerequisite, belong to the scope of protection of the invention.
There is provided a kind of complex with wrinkle removal function, comprise triterpene saponin and triterpenic acid, described triterpene saponin and described triterpenic acid are the active component derived from Herba Centellae.Described triterpene saponin is one or both in asiaticoside, asiaticoside.Described triterpenic acid is one or both in asiatic acid, Madecassic acid.Complex of the present invention is shown in embodiment below with Contrast on effect when being used alone triterpene saponin or triterpenic acid.
Embodiment one:
(1) normal human skin fibroblast is inoculated in Tissue Culture Plate with suitable density respectively, uses 0.25% trypsin digestion and cell, is then made into single cell suspension, with every hole 1 × 10 with the DMEM culture fluid containing percent by volume being the hyclone of 10%
5individually be inoculated in 96 orifice plates or Tissue Culture Dish (30mm), attach overnight, abandons supernatant.Then add not containing the DMEM culture medium of hyclone, hungry cultivation 24h, synchronization process respectively organizes cell, in 5%CO
2, cultivate in 37 DEG C of incubators.
Experiment point undressed blank group, and 5 processed group, be respectively the asiaticoside 50ug/ml of processed group 1, the asiaticoside 50ug/ml of processed group 2, the asiaticoside 25ug/ml of processed group 3 and asiaticoside 25ug/ml, the asiaticoside 25ug/ml of processed group 4 and asiatic acid 25ug/ml, the asiaticoside 25ug/ml of processed group 5 and Madecassic acid 25ug/ml, 5 processed group are all used and are not prepared containing the DMEM culture medium of hyclone.After cell Nature enemy, add active component respectively to process, and matched group is set, 6 multiple holes are set respectively, after cultivating 48h, supernatant is centrifugal, according to I procollagen type protein content detection kit (ProcollagenTypeIC-Peptide (PIP) EIAKit) description, detects I procollagen type protein content in supernatant.
(2) experimental result: based on quantitative result, is defined as 100% with the content of I procollagen type albumen in blank group culture fluid.When interpolation active component carries out cell culture, the content of the I procollagen type albumen of processed group 1 is 139.45 ± 4.75%, the content of processed group 2 is 140.97 ± 3.89%, the content of processed group 3 is 146.18 ± 5.01%, the content of processed group 4 is 226.32 ± 4.65%, and the content of processed group 5 is 212.75 ± 3.01%.Be used alone or in combination asiaticoside and compare with asiaticoside, after adding asiatic acid or Madecassic acid, the facilitation of I procollagen type protein excretion can be significantly improved.
Embodiment two:
Test according to the method for cell culture in embodiment one, experiment point undressed blank group, and 4 processed group, be respectively the asiatic acid 30ug/ml of processed group 1, the Madecassic acid 30ug/ml of processed group 2, the asiatic acid 15ug/ml of processed group 3 and Madecassic acid 15ug/ml, the asiatic acid 15ug/ml of processed group 4 and asiaticoside 15ug/ml, the asiatic acid 15ug/ml of processed group 5 and asiaticoside 15ug/ml.5 processed group are all used and are not prepared containing the DMEM culture medium of hyclone.After cell Nature enemy, add active component respectively to process, and matched group is set, 6 multiple holes are set respectively, after cultivating 48h, supernatant is centrifugal, according to I procollagen type protein content detection kit (ProcollagenTypeIC-Peptide (PIP) EIAKit) description, detects I procollagen type protein content in supernatant.
(2) experimental result: based on quantitative result, is defined as 100% with the content of I procollagen type albumen in blank group culture fluid.When interpolation active component carries out cell culture, the content of the I procollagen type albumen of processed group 1 is 121.34 ± 3.01%, the content of processed group 2 is 126.18 ± 4.10%, the content of processed group 3 is 124.551 ± 3.15%, the content of processed group 4 is 193.32 ± 3.41%, and the content of processed group 5 is 187.75 ± 4.27%.Be used alone or in combination asiatic acid and compare with Madecassic acid, after adding asiaticoside or asiaticoside, the facilitation of I procollagen type protein excretion can be significantly improved.Therefore, the asiatic acid of triterpenic acid or Madecassic acid, asiaticoside or the composite use of asiaticoside with triterpene saponin, can significantly improve the facilitation of triterpene saponin to I procollagen type protein excretion.
Embodiment three:
Being the application of complex in cosmetics of the triterpene saponin and triterpenic acid with remarkable wrinkle removal function below, is that technology forms the mixing of each composition routinely.
Cosmetic formulations one: wrinkle removal frost, by percentage to the quality, glycerol 6.0%, butanediol 3.0%, 1, 2-pentanediol 2.0%, EDETATE SODIUM 0.1%, PEG-100 stearate 1.5%, glyceryl stearate 0.5%, caprylic/capric/myristic acid/glycerol stearate three ester 6.0%, Cholesteryl hydroxystearate 1.0%, spermol 2.0%, Butyrospermum parkii (BUTYROSPERMUMPARKII) fruit fat 2.0%, behenyl alcohol 0.5%, polydimethylsiloxane 1.0%, cholesterol 0.2%, xanthan gum 0.3%, hyaluronate sodium 0.05%, phenoxyethanol 0.3%, methyl hydroxybenzoate 0.2%, ethyl hydroxybenzoate 0.1%, essence 0.1%, complex 0.1%, deionized water polishing to 100%, in wherein said complex, the mass ratio of triterpene saponin and triterpenic acid is 3:1.
Cosmetic formulations two: wrinkle removal emulsion, by percentage to the quality, glycerol 6.0%, butanediol 5.0%, 1, 2-pentanediol 2.5%, EDETATE SODIUM 0.1%, Natrulon H-10 stearate 1.0%, Natrulon H-10 distearate 0.5%, glyceryl stearate 0.5%, dimethyl siloxane 1.0%, stearic acid 0.5%, hydrolecithin 0.2%, hyaluronate sodium 0.05%, xanthan gum 0.3%, phenoxyethanol 0.3%, methyl hydroxybenzoate 0.2%, ethyl hydroxybenzoate 0.1%, essence 0.1%, complex 0.2%, deionized water polishing to 100%, in wherein said complex, the mass ratio of triterpene saponin and triterpenic acid is 5:1.
Cosmetic formulations three: wrinkle removal essence, by percentage to the quality, glycerol 6.0%, butanediol 3.0%, 1, 2-pentanediol 2.0%, EDETATE SODIUM 0.1%, hydrolecithin 0.5%, Natrulon H-10 oleate 0.3%, caprylic/capric/myristic acid/glycerol stearate three ester 1.0%, Cholesteryl hydroxystearate 0.5%, squalane 1.0%, dipentaerythritol hexahydroxystearic acid ester/six stearate/six rosinate 0.5%, cholesterol 0.2%, polymethylsilsesquioxane 1.0%, polydimethylsiloxane 1.0%, xanthan gum 0.3%, hyaluronate sodium 0.03%, phenoxyethanol 0.3%, methyl hydroxybenzoate 0.2%, ethyl hydroxybenzoate 0.1%, essence 0.05%, complex 0.05%, deionized water polishing to 100%, in wherein said complex, the mass ratio of triterpene saponin and triterpenic acid is 2:1.
The foregoing is only embodiments of the invention; not thereby the scope of the claims of the present invention is limited; every utilize description of the present invention to do equivalent structure or equivalent flow process conversion; or be directly or indirectly used in other relevant technical field, be all in like manner included in scope of patent protection of the present invention.
Claims (9)
1. have a complex for wrinkle removal function, it is characterized in that, comprise triterpene saponin and triterpenic acid, described triterpene saponin and described triterpenic acid are the active component derived from Herba Centellae.
2. the complex with wrinkle removal function according to claim 1, is characterized in that, described triterpene saponin is one or both in asiaticoside, asiaticoside.
3. the complex with wrinkle removal function according to claim 1, is characterized in that, described triterpenic acid is one or both in asiatic acid, Madecassic acid.
4. the application with the complex of wrinkle removal function according to claim 1, is characterized in that, the application of described complex in Wrinkle removing cosmetic.
5. the complex with wrinkle removal function according to claim 4, is characterized in that, in described Wrinkle removing cosmetic, the mass content of the triterpene saponin in complex is 0.001-10%, and the mass content of triterpenic acid is 0.001-10%.
6. the application with the complex of wrinkle removal function according to claim 4, is characterized in that, described Wrinkle removing cosmetic comprises described complex and other functional active components.
7. the application with the complex of wrinkle removal function according to claim 4, it is characterized in that, the component of described wrinkle removal frost is: by percentage to the quality, glycerol 6.0%, butanediol 3.0%, 1, 2-pentanediol 2.0%, EDETATE SODIUM 0.1%, PEG-100 stearate 1.5%, glyceryl stearate 0.5%, caprylic/capric/myristic acid/glycerol stearate three ester 6.0%, Cholesteryl hydroxystearate 1.0%, spermol 2.0%, Butyrospermum parkii fruit fat 2.0%, behenyl alcohol 0.5%, polydimethylsiloxane 1.0%, cholesterol 0.2%, xanthan gum 0.3%, hyaluronate sodium 0.05%, phenoxyethanol 0.3%, methyl hydroxybenzoate 0.2%, ethyl hydroxybenzoate 0.1%, essence 0.1%, complex 0.1%, deionized water polishing to 100%, in wherein said complex, the mass ratio of triterpene saponin and triterpenic acid is 3:1.
8. the application with the complex of wrinkle removal function according to claim 4, it is characterized in that, the component of described wrinkle removal emulsion is: by percentage to the quality, glycerol 6.0%, butanediol 5.0%, 1, 2-pentanediol 2.5%, EDETATE SODIUM 0.1%, Natrulon H-10 stearate 1.0%, Natrulon H-10 distearate 0.5%, glyceryl stearate 0.5%, dimethyl siloxane 1.0%, stearic acid 0.5%, hydrolecithin 0.2%, hyaluronate sodium 0.05%, xanthan gum 0.3%, phenoxyethanol 0.3%, methyl hydroxybenzoate 0.2%, ethyl hydroxybenzoate 0.1%, essence 0.1%, complex 0.2%, deionized water polishing to 100%, in wherein said complex, the mass ratio of triterpene saponin and triterpenic acid is 5:1.
9. the application with the complex of wrinkle removal function according to claim 4, it is characterized in that, the component of described wrinkle removal essence is: by percentage to the quality, glycerol 6.0%, butanediol 3.0%, 1, 2-pentanediol 2.0%, EDETATE SODIUM 0.1%, hydrolecithin 0.5%, Natrulon H-10 oleate 0.3%, caprylic/capric/myristic acid/glycerol stearate three ester 1.0%, Cholesteryl hydroxystearate 0.5%, squalane 1.0%, dipentaerythritol hexahydroxystearic acid ester/six stearate/six rosinate 0.5%, cholesterol 0.2%, polymethylsilsesquioxane 1.0%, polydimethylsiloxane 1.0%, xanthan gum 0.3%, hyaluronate sodium 0.03%, phenoxyethanol 0.3%, methyl hydroxybenzoate 0.2%, ethyl hydroxybenzoate 0.1%, essence 0.05%, complex 0.05%, deionized water polishing to 100%, in wherein said complex, the mass ratio of triterpene saponin and triterpenic acid is 2:1.
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| CN201510859743.9A CN105287310A (en) | 2015-12-01 | 2015-12-01 | Compound with wrinkle removing function and application of compound |
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| CN201510859743.9A CN105287310A (en) | 2015-12-01 | 2015-12-01 | Compound with wrinkle removing function and application of compound |
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Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105662974A (en) * | 2016-03-10 | 2016-06-15 | 江苏隆力奇生物科技股份有限公司 | Preparation with skin light aging prevention function and application of preparation |
| CN106074264A (en) * | 2016-07-05 | 2016-11-09 | 上海相宜本草化妆品股份有限公司 | A kind of additive and comprise the cosmetics of this additive |
| CN106727013A (en) * | 2017-01-04 | 2017-05-31 | 广州聚澜健康产业研究院有限公司 | A kind of anti-apolexis composition and its application |
| JP2017158538A (en) * | 2016-03-04 | 2017-09-14 | 御木本製薬株式会社 | Emulsion composition |
| CN107412235A (en) * | 2017-06-28 | 2017-12-01 | 上海交通大学 | Promote combination of monomers and its application of PC12 cell differentiations in a kind of centella |
| CN108265023A (en) * | 2016-12-30 | 2018-07-10 | 深圳华大基因研究院 | A kind of enhancer of proliferation and its application |
| CN109806177A (en) * | 2019-03-21 | 2019-05-28 | 辉达生物医药（苏州）有限公司 | A kind of high-efficiency moisturizing composition |
| CN109846776A (en) * | 2019-01-30 | 2019-06-07 | 广州诗美化妆品有限公司 | A kind of centella asiatica extract and its preparation method and application |
| CN113230172A (en) * | 2021-05-24 | 2021-08-10 | 泉州达浔生物科技有限公司 | Cosmetic or dermatological composition, preparation method and application thereof |
| WO2021258565A1 (en) * | 2020-06-23 | 2021-12-30 | 中南大学 | Application of carnosic acid in preparation of anti-photoaging products |
| WO2023180600A1 (en) * | 2022-03-23 | 2023-09-28 | Monteloeder S.L. | Composition of plant extracts for reducing the effects of aging by preventing or delaying cellular senescence |
| CN117898983A (en) * | 2023-12-13 | 2024-04-19 | 王叔和生物医药(武汉)有限公司 | High-delivery asiatic acid/asiaticoside/madecassic acid/asiatic acid extract flexible liposome and preparation method and application thereof |
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Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017158538A (en) * | 2016-03-04 | 2017-09-14 | 御木本製薬株式会社 | Emulsion composition |
| CN105662974A (en) * | 2016-03-10 | 2016-06-15 | 江苏隆力奇生物科技股份有限公司 | Preparation with skin light aging prevention function and application of preparation |
| CN106074264A (en) * | 2016-07-05 | 2016-11-09 | 上海相宜本草化妆品股份有限公司 | A kind of additive and comprise the cosmetics of this additive |
| CN108265023B (en) * | 2016-12-30 | 2021-12-03 | 深圳华大生命科学研究院 | Proliferation promoter and application thereof |
| CN108265023A (en) * | 2016-12-30 | 2018-07-10 | 深圳华大基因研究院 | A kind of enhancer of proliferation and its application |
| CN106727013A (en) * | 2017-01-04 | 2017-05-31 | 广州聚澜健康产业研究院有限公司 | A kind of anti-apolexis composition and its application |
| CN107412235A (en) * | 2017-06-28 | 2017-12-01 | 上海交通大学 | Promote combination of monomers and its application of PC12 cell differentiations in a kind of centella |
| CN109846776A (en) * | 2019-01-30 | 2019-06-07 | 广州诗美化妆品有限公司 | A kind of centella asiatica extract and its preparation method and application |
| CN109806177A (en) * | 2019-03-21 | 2019-05-28 | 辉达生物医药（苏州）有限公司 | A kind of high-efficiency moisturizing composition |
| WO2021258565A1 (en) * | 2020-06-23 | 2021-12-30 | 中南大学 | Application of carnosic acid in preparation of anti-photoaging products |
| CN113230172A (en) * | 2021-05-24 | 2021-08-10 | 泉州达浔生物科技有限公司 | Cosmetic or dermatological composition, preparation method and application thereof |
| CN113230172B (en) * | 2021-05-24 | 2022-07-01 | 泉州达浔生物科技有限公司 | Cosmetic or dermatological composition, preparation method and application thereof |
| WO2023180600A1 (en) * | 2022-03-23 | 2023-09-28 | Monteloeder S.L. | Composition of plant extracts for reducing the effects of aging by preventing or delaying cellular senescence |
| CN117898983A (en) * | 2023-12-13 | 2024-04-19 | 王叔和生物医药(武汉)有限公司 | High-delivery asiatic acid/asiaticoside/madecassic acid/asiatic acid extract flexible liposome and preparation method and application thereof |
| CN117898983B (en) * | 2023-12-13 | 2024-09-17 | 王叔和生物医药(武汉)有限公司 | High-delivery asiatic acid/asiaticoside/madecassic acid/asiatic acid extract flexible liposome and preparation method and application thereof |
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