CN105250696A - Traditional Chinese medicine gel capable of promoting skin wound to heal and preparation method of traditional Chinese medicine gel - Google Patents
Traditional Chinese medicine gel capable of promoting skin wound to heal and preparation method of traditional Chinese medicine gel Download PDFInfo
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Abstract
The invention belongs to the field of traditional Chinese medicine, discloses a traditional Chinese medicine gel capable of promoting a skin wound to heal and is characterized by comprising a high molecular material, a penetration enhancer, a surfactant, a pH modifier, a preservative, water and traditional Chinese medicine clear paste prepared through raw materials of hyperforin perforatum, herb of denseleaf crazyweed, radix zanthoxyli, herb of thymeleaf speed welt, euonymus fortunei, hibiscus mutabilis and bletilla striata. According to the Chinese medicine gel capable of promoting the skin wound to heal, all medicine interacts collaboratively, stasis can be eliminated to subdue swelling, heat and toxic materials can be cleaned away, and effects of antisepsis and anti-inflammation as well as removing necrotic tissue and promoting granulation are realized. The effects of rapidly relieving patient's pain, rapidly healing the wound, removing blood stasis for promoting tissue regeneration and activating blood and dissipating stasis are realized; besides, the traditional Chinese medicine gel is uniform and fine and easy to coat after folding, the residence time is long, skin won't be tightened, the gel is stable to release, the stability is good, no toxic or side effect exists, the obedience of a patient for receiving treatment is improved greatly, and the life quality of the patient is improved.
Description
Technical field
The embodiment of the present invention, specifically discloses a kind of Chinese medicine gel promoting skin wound healing and preparation method thereof.
Background technology
From ancient times to the present, skin trauma, damage are all surgical clinical commonly encountered diseases, such as burn and scald, various wound, skin ulcer, mucosa injury etc. all belong to surgical wound, as cured not in time, pathogenic factor and antibacterial invade, and not only can expand wound surface, skin ulceration, even cause infection, produce septicemia, cause death.Repair in trauma is one of study hotspot in surgical field all the time.Wound healing is the pathological process caused after wound, is jointly participated in by multiple somatomedin, cytokine, inflammatory cell and repair cell, the process of complexity and hight coordinate.Wound is complicated, and influence factor is numerous, except fibroblast, inflammatory cell, somatomedin, Fn Fiberonectin trace element, pH value etc., also has extracellular matrix, epidermis cell and cytokine profiles.
Modern medicine is thought, the agglutination of wound surface is divided into local inflammation reaction, cell proliferation and differentiation and Reconstruction 3 the different stage overlapping again each other substantially.These 3 any one links of stage are affected, and all may cause the prolongation of wound healing time, and therefore, effective controls local infects, promote cell proliferation, increase collage synthesis and wound surface nutrition, becomes and accelerates the effective method of wound healing.
But Shortcomings in conventional wound medicine.As the use of disinfectant (povidone iodine etc.), adhesive bandage, sterilizing effect can be played, but can not trauma pain be reduced; External lidocaine emulsifiable paste and aerosol, can play analgesic effect, but infection control is poor; Other is principal agent with Chinese medicine extract, is mostly medical mechanical domain, and quality control standard is not strict; Topical drug dosage form mostly being ointment, liniment, there is inconvenience in administration.
People can promote the medicine that wound surface heals as early as possible and method always after constantly seeking, exploring wound.The traditional Chinese medical science has unique understanding to wound, and external application Chinese medicine has unique short more curative effect.The mechanism of its wound healing mainly plays its Mutiple Targets, too many levels, multi-level comprehensive regulation effect for the major influence factors of wound healing.
Summary of the invention
In view of the deficiencies in the prior art, inventor is on the basis furtherd investigate folk remedy, provide a kind of Chinese medicine gel promoting skin wound healing, it has effect of heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, promoting tissue regeneration and wound healing, it is evident in efficacy, safe and reliable, have no side effect, may be used for the wound of any position on health, any size, there is wide potential applicability in clinical practice.
The object of the present invention is achieved like this:
Promote a Chinese medicine gel for skin wound healing, it is characterized in that the Chinese medicine clear paste comprising macromolecular material, penetration enhancer, surfactant, pH adjusting agent, wetting agent, antiseptic, water and be made up of following raw material: Herba Hyperici perforati, Herba Oxytropis Myriophyllae, Radix Zanthoxyli, Herba Veronicae Serpyllifoliae, Caulis Seu Folium Euonymi Fortunei, Flos Hibisci Mutabilis, the Pseudobulbus Bletillae (Rhizoma Bletillae);
Wherein: by weight percentage, macromolecular material 0.5-8%, penetration enhancer 1-28%, surfactant 1-3.5%, pH adjusting agent 0.5-5%, wetting agent 6-10%, antiseptic 0.2-0.7%, Chinese medicine clear paste 5-15%, surplus is water.
Because the composition of Chinese medicine clear paste is comparatively complicated, may have an effect with macromolecular material, or because Chinese medicine clear paste is that height oozes system, irreversible destruction is produced to the structure of gel, therefore preferably, high-molecular matrix material described above is carbomer, chitosan, hydroxypropyl emthylcellulose, methylcellulose, the combination in any of one of them or they of sodium carboxymethyl cellulose, when the preparation method of described gel, when high-molecular matrix material is carbomer, add PH regulator, PH regulator is sodium hydroxide, potassium hydroxide, sodium bicarbonate, ethylenediamine, any one in triethanolamine.
Further, penetration enhancer described above is the combination in any of one of them or they of laurocapram, propylene glycol, ethanol.
Further, surfactant described above is one of poly yamanashi esters, polyoxyethylene fatty acid ester class, polyoxyethylene aliphatic alcohol ether class or their combination in any.
Further, wetting agent described above is one of glycerol, propylene glycol or their combination.
Further, antiseptic described above can be the combination in any of benzoic acid, sodium benzoate, chlorobutanol, methyl hydroxybenzoate, ethyl hydroxybenzoate or butyl ester one of them or they.
Further, high-molecular matrix material described above is Acritamer 940 and hydroxypropyl emthylcellulose; Described wetting agent is glycerol; Described antiseptic is methyl parahydroxybenzoate; Described penetration enhancer is laurocapram; Described surfactant is Tween-80; By weight percentage, Acritamer 940 1.5-3.5%, hydroxypropyl emthylcellulose 1.0-2.0%, laurocapram 1-3%, Tween-80 1-3.5%, pH adjusting agent 1.5-3.5%, glycerol 6-10%, methyl hydroxybenzoate 0.2-0.5%, Chinese medicine clear paste 5-15%, surplus is water.
In order to increase the chemiluminescence of effective active composition in clear paste, to reach better therapeutic effect, preferably, described Chinese medicine clear paste is processed by the crude drug of following weight parts and is prepared from: Herba Hyperici perforati 9-19 part, Herba Oxytropis Myriophyllae 8-18 part, Radix Zanthoxyli 5-15 part, Herba Veronicae Serpyllifoliae 5-15 part, Caulis Seu Folium Euonymi Fortunei 15-35 part, Flos Hibisci Mutabilis 8-18 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 6-16 part.
Further preferably, Chinese medicine clear paste described above is processed by the crude drug of following weight parts and is prepared from: Herba Hyperici perforati 12-17 part, Herba Oxytropis Myriophyllae 11-15 part, Radix Zanthoxyli 8-13 part, Herba Veronicae Serpyllifoliae 10-15 part, Caulis Seu Folium Euonymi Fortunei 23-28 part, Flos Hibisci Mutabilis 10-15 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 10-15 part.
Further preferably, Chinese medicine clear paste described above is processed by the crude drug of following weight parts and is prepared from: Herba Hyperici perforati 15 parts, Herba Oxytropis Myriophyllae 12 parts, Radix Zanthoxyli 10 parts, Herba Veronicae Serpyllifoliae 12 parts, Caulis Seu Folium Euonymi Fortunei 25 parts, Flos Hibisci Mutabilis 10 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 14 parts.
Prescription analysis: Herba Hyperici perforati energy heat-clearing and toxic substances removing, astringing to arrest bleeding; Radix Zanthoxyli promoting the circulation of QI to relieve pain, blood circulation promoting and blood stasis dispelling, dispelling wind and removing obstruction in the collateral, two medicine compatibilities use, and both heat-clearing and toxic substances removing, again blood circulation promoting and blood stasis dispelling, removing obstruction in the collateral to relieve pain are monarch drug.Herba Oxytropis Myriophyllae heat-clearing and toxic substances removing, detumescence hemostasis; Herba Veronicae Serpyllifoliae promoting blood circulation to remove blood stasis, hemostasis, removing toxic substances, the equal sweet in the mouth energy of two medicines and principal drug assistance are ministerial drug.Caulis Seu Folium Euonymi Fortunei pungent temperature energy relaxing muscles and tendons and activating QI and blood in the collateral, hemostasis repercussive; Flos Hibisci Mutabilis is worked hard cool, energy heat-clearing and toxic substances removing, cooling blood for hemostasis, detumescence and apocenosis; Pseudobulbus Bletillae (Rhizoma Bletillae) hardship can expel the heat-evil, pungent energy eliminating stagnation, astringing to arrest bleeding, detumescence and promoting granulation.All medicines are worked in coordination with mutually, both can dissipating blood stasis for subsidence of swelling pain relieving, again can heat-clearing and toxic substances removing, anti-inflammation, removing the necrotic tissue and promoting granulation.Namely reach and alleviate patient's pain fast, make wound healing, reach promoting tissue regeneration by removing blood stasis again, the effect of invigorating blood circulation addiction.
In side, the pharmacological property of each medical material is as follows:
Herba Hyperici perforati: [nature and flavor] bitter in the mouth; Puckery; Property is put down.[return through] Liver Channel.[function cures mainly] astringing to arrest bleeding; Regulating menstruation lactogenesis; Heat-clearing and toxic substances removing; Dampness removing.Main spitting of blood; Spit blood; Discharging fresh blood stool; Metrorrhagia; Traumatic hemorrhage; Menstruation is fried and is adjusted; Breast woman agalactia; Jaundice; Have sore throat; Conjunctival congestion and swelling pain; Urinary tract infection; The raw skin ulcer of mouth and nose; Carbuncle furuncle and phyma poison; Burn and scald.
Herba Oxytropis Myriophyllae: [nature and flavor] are sweet; Cold.[return through] lung; Liver; Spleen channel.[function cures mainly] heat-clearing and toxic substances removing; Detumescence hemostasis.Main flow sense; Laryngopharynx swelling and pain; Carbuncle pyogenic infections from tumour or sore; Injury from falling down; Blood stasis swelling; Various hemorrhage.
Radix Zanthoxyli: [nature and flavor] are bitter, pungent, flat; Slightly poisonous.[return through] returns liver, stomach warp.[function cures mainly] promoting the circulation of QI to relieve pain, blood circulation promoting and blood stasis dispelling, dispelling wind and removing obstruction in the collateral.The traumatic injury caused for qi depression to blood stasis, rheumatic arthralgia, stomachache, toothache, venom; The burning hot wound of external treatment soup.
Herba Veronicae Serpyllifoliae: [nature and flavor] sweet in the mouth; Bitter; Puckery; Property is put down.[return through] returns Liver Channel.[function cures mainly] promoting blood circulation to remove blood stasis; Hemostasis; Removing toxic substances.Main traumatic injury; Menoxenia; Wound hemorrhage; Aphtha; Burn and scald.
Caulis Seu Folium Euonymi Fortunei: [nature and flavor] are bitter; Sweet; Micro-pungent; Tepor.[return through] liver; Spleen; Kidney channel.[function cures mainly] relaxing muscles and tendons and activating QI and blood in the collateral; Kidney tonifying strengthens waist; Hemostasis repercussive.Main soreness of waist and knee joint of suffering from a deficiency of the kidney; Hemiplegia; Rheumatic arthralgia; Infantile convulsion; Spitting of blood; Spit blood; Metrorrhagia; Have through uncomfortable; Uterine prolapse; Injury and bone fracture; Wound hemorrhage.
Flos Hibisci Mutabilis: [nature and flavor] are pungent; Micro-hardship; Cool.[return through] lung; The heart; Liver Channel.[function cures mainly] heat-clearing and toxic substances removing; Cooling blood for hemostasis; Detumescence and apocenosis.Main cough due to lung-heat; Spit blood; Conjunctival congestion and swelling pain; Metrorrhagia; Leucorrhea; Diarrhoea; Stomachache; Carbuncle; Furuncle; Venom; Burn due to hot liquid or fire; Traumatic injury.
The Pseudobulbus Bletillae (Rhizoma Bletillae): [nature and flavor] are bitter; Sweet; Puckery; Cold.[return through] lung; Stomach warp.[function cures mainly] astringing to arrest bleeding; Detumescence and promoting granulation.Main spitting of blood; Spit blood; Epistaxis; Have blood in stool; Traumatic hemorrhage; Carbuncle pyogenic infections from tumour or sore; Scald and burn; Rhagadia manus et pedis; Anal fissure.
Present invention also offers a kind of preparation method promoting the Chinese medicine gel of skin wound healing, it comprises the following steps:
Get described crude drug, decoct with water 2 ~ 3 times, each amount of water is 6 ~ 10 times of described crude drug weight, and decocting time is 1 ~ 2 hour, filters; Merging filtrate, leave standstill, getting supernatant concentration to relative density is 1.10 ~ 1.15 (60 DEG C record), adds ethanol and makes the volumn concentration of ethanol reach 70% ~ 80% (preferably 75%), and after stirring, precipitate with ethanol leaves standstill; Get supernatant and reclaim ethanol, and to be concentrated into relative density be 1.10 ~ 1.15 (60 DEG C record), obtains described Chinese medicine clear paste;
Get surfactant, mix with gained Chinese medicine clear paste after thin up, obtain the first mixture; Macromolecular material is fully swelling, add wetting agent, antiseptic, be uniformly mixed, obtain the second mixture; By the first mixture, the second mixture and described short mixing thoroughly, moisturizing, to recipe quantity, is uniformly mixed, after adjust ph and get final product.
The present invention is further illustrated below by way of testing.These tests comprise the zoopery of inventive gel agent and clinical observation on the therapeutic effect test etc.
One, Chinese medicine gel of the present invention is to the experimentation of rabbit skin wound healing
1 materials and methods
1.1 laboratory animal rabbit 30, body weight 2.0-2.5kg, male and female dual-purpose, is provided by the Academy of Medical Sciences, Shandong animal experimental center.
1.2 experimental models and process: the urethane with 20% in rabbit auricular vein injecting anesthetic, by 5mL/kg administration.Every rabbit back cuts off 3 pieces, the hair-fields of 6cm × 6cm, respectively measures the region of 3cm × 4cm and picric acid is marked with ruler.Cut off epidermis with scalpel along graticule, visible thin film, gently pulls striping, stays a little blood as seen, and stop wound, rear each wound all uses iodine disinfection.Experimental group is evenly coated with Chinese medicine gel of the present invention, and matched group is coated with the sulfadiazine silver cream of equivalent, and blank group is coated with iodine tincture, with sterile gauze wrapping after coating, changes dressings every day 1 time and observes indices.Test and put to death rabbit on the 20th day, remove crust sheet, and take off the tissue of one piece of suitable size from each wound surface, light-emitting lens inspection.
1.3 experimental index
1.3.1 wound healing rate: each group rabbit measured wound healing area respectively at the 4th, 5,6,7,11,12 day, calculated healing rate.
1.3.2 observe exudate amount number and extinction time: start healing time, namely wound surface periphery starts desquamation.Complete healing time, standard forms a scab all to come off, and new skin grows.
1.3.3 light microscopy checking: the last 1d terminated in experiment, does skin biopsy, observes inflammatory cell infiltration situation and granulation tissue growing state.
1.4 statistical methods: measurement data with
represent, and adopt rank test to data, enumeration data adopts X 2 test, and P < 0.05 has statistical significance for difference.
2 results
2.1 wound healing rates: compare with blank group, experimental group and matched group all can improve rabbit wound healing rate (P < 0.05, P < 0.01).Experimental group is compared with matched group, and 5d, 7d, 12d redissolution wound healing rate difference has significance (P < 0.05), and test group onset is very fast, better effects if.In table 1.
Table 1 wound healing rate compares:
%
Note: compare with blank group, * P < 0.05, * * P < 0.01; Compare with matched group,
#p < 0.05.
2.2 wound healing situations: the 2nd day of experiment, often organizing wound has transudate, and wound not yet starts healing, can not observe the difference of 3 groups.Experimental group: have the transudate of 6 rabbit wound surface substantially to disappear on the 3rd day, and start incrustation healing, within the 4th day, all start healing, at the end of experiment in the 12nd day, have 4 wounds healed completely.Matched group: have the transudate of 4 rabbit wound surface substantially to disappear on the 3rd day, and start incrustation healing, within the 4th day, all start healing, at the end of experiment in the 12nd day, have 3 wounds healed completely.Blank group: transudate does not disappear on the 3rd day substantially, and wound not yet starts healing, all starts healing on the 4th day, has 0 wound healed completely at the end of experiment in the 12nd day.
12nd day om observation result after 2.3 wounds: experimental group epidermis covers substantially, and has thin layer granulation tissue, the visible scar tissue of lower floor.Matched group wound surface has a small amount of epidermis to cover, visible granulation tissue, and a little cicatrix also has a small amount of inflammatory cell infiltration, has 2 rabbit wound surface to cover without epidermis.Blank is formed face epidermis major part and to be come off necrosis, and inflammatory cell infiltrates in a large number, and visible wound surface covers a large amount of granulation tissue.
Results of animal shows: the effect of inventive gel agent treatment wound is obvious, more excellent than the curative effect of matched group.
Two, Chinese medicine gel of the present invention is to the experimentation of Rat Experimental II degree wound tissue healing
1 data and method
1.1 laboratory animal groupings are prepared with model: cleaning grade SD rat 30, weight 230 ~ 250g, male and female are not limit.100mL/L water and chloral liquid, intraperitoneal injection anesthesia (30mg/kg), loses hair or feathers in back.Next day anaesthetizes with method, uses constant temperature and pressure scald apparatus, and with diameter 2.5cm, 90 DEG C, 2.3kPa pressure scalds rat dorsum skin 15s, makes the dark II degree wound surface 3 (through proved by pathology) of diameter 2.5cm, each wound surface interval 1cm.Middle wound surface is for scalding matched group, outer painting inventive gel substrate; Other two wound surface are respectively zinc sulfadiazine paste treatment group and inventive gel agent treatment group, respectively the outer gel treatment being coated with zinc sulfadiazine paste and the embodiment of the present invention 1.Exposure method, wound surface is changed dressings 1 time every day.
1.2 observation indexs:
1.2.1 wound surface gross examination of skeletal muscle: when every day changes dressings, perusal edema wound oozes out degree, whether dry, there are all rednesses of noinvasive and secretions etc.As found that there is abnormal secretion thing, sending and doing antibacterial culturing and qualification.
1.2.2 observe wound healing time: turn to healing standard with the complete epithelium of wound surface, and confirm through wound surface pathological section HE dyeing.
1.3 statistical methods: measurement data with
represent, and adopt t inspection to data, P < 0.05 has statistical significance for difference.
2 results
2.1 respectively form face gross examination of skeletal muscle and hinder rear 1 ~ 2d scald matched group wound surface skin-color in vain, and swelling, has and ooze out and create week redness.Zinc sulfadiazine paste group and inventive gel agent form that face noinvasive week is red and swollen, and after wound, face drying is formed in the agent of 2d inventive gel, after wound 3d all the other 2 form face and be dried to crust.Zinc sulfadiazine paste group and inventive gel agent group in agglutination under crust without secretions, there is secretions under 14d part wound surface (6/20) crust in matched group, bacteria cultivation results is staphylococcus aureus after wound.
2.2 respectively organize healing time: scalding matched group wound surface the average healing is (18.9 ± 4.7) d; Zinc sulfadiazine paste forms face the average healing for (17.8 ± 4.3) d; Inventive gel agent forms face the average healing for (14.3 ± 3.5) d, and compare with matched group, difference has statistical significance (P < 0.01); With zinc sulfadiazine paste group, difference also has statistical significance (P < 0.05).
Above-mentioned results of animal shows: the effect of inventive gel agent treatment wound is obvious; more excellent than the curative effect of matched group; its mechanism may be promote that wound blood vessels is rebuild; keep good blood circulation; reduce the infiltration of inflammatory cell; the hypertrophy accelerating collagen fiber forms cicatrix, and protection wound is protected from infection.
Three, clinical observation test
1 data and method
1.1 physical data: choose in December, 2012 in December ,-2014 at the court's emergency treatment, the outpatient service Patients with 300 Cases medical because of traumatic wound, be divided into experimental group and matched group at random.Experimental group 200 example, age 6-76 year, 37.3 ± 8.5 years old mean age.Wherein facial wound 28 example, trunk 46 example, extremity 126 example; Wound length is less than 5cm person 146 example, and wound length is greater than 5cm person 54 example, and wound depth is person 162 example within 0.5cm, and wound depth is in 0.5cm-1.0cm person 38 example.Matched group 100 example, 6 years old-72 years old age, 36.8 ± 7.7 years old mean age.Wherein facial wound 15 example, trunk 22 example, extremity 63 example; Wound length is less than 5cm person 72 example, and wound length is greater than 5cm person 28 example, and wound depth is person 80 example within 0.5cm, and wound depth is in 0.5cm-1.0cm person 20 example.Above patient all bleeds because wound causes open wound, pain is gone to a doctor, until recovery from illness.Two groups of Genders, age, wound location, sewing needle number, wound degrees etc. are through statistical procedures, and there was no significant difference (P > 0.05), has comparability.
1.2 Therapeutic Method:
Experimental group: to traumatic wound debridement or after sewing up, wound surface and surrounding skin smear Chinese medicine gel prepared by the embodiment of the present invention 1, and continuous 1-2 minute, is not absorbed as suitable with surrounding skin, changes dressings every day 1 time, until wound healing or take out stitches.
Matched group: to traumatic wound debridement or sew up after, with 5% iodophor disinfection wound surface and surrounding skin, apply alcohol gauze, every day change dressings 1 time.
1.3 observation index:
Two groups of patient hemostasis, detumescence, analgesic time, wound healing situation.
1.4 statistical methods: measurement data with
represent, and adopt t inspection to data, P < 0.05 has statistical significance for difference.
2 experimental results
2.1 liang of group hemostasis, detumescences, analgesic effects compare: in experimental group after 200 routine patient's wound external application inventive gel agent, can stop blooding rapidly, pain relieving, detumescence, with matched group, there is pole significant difference (P < 0.01).In table 2.And experimental group when changing dressings or take out stitches without pain or slightly keenly feel.And matched group patient is at more change dressings or when taking out stitches, and has pain in various degree.
Table 2 liang group hemostasis, detumescence, analgesic effect compare,
| Group | Case load | Bleeding stopping period/h | Swelling time/h | Analgesic time/h |
| Experimental group | 200 | 0.35±0.45 # | 30.0±12.5 # | 12.3±15.4 # |
| Matched group | 100 | 3.46±1.42 | 108.5±25.3 | 78.6±22.2 |
Note: compare with matched group,
#p < 0.05.
2.2 liang of group wound infections, wound healing situations compare: after treatment, and none example of experimental group infects, and within average 5 days, take out stitches, I phase healing rate can reach 98.5%.Matched group is taken out stitches for average 8 days, and I phase healing rate is only 73%, and has 8 routine wounds to infect.Refer to table 3.
Table 3 liang group wound infection, wound healing situation, example
| Group | Case load | The I phase heals | The II phase heals | Wound infection |
| Experimental group | 200 | 197 | 3 | 0 |
| Matched group | 100 | 73 | 27 | 8 |
Note: the I phase heals and refers to that tissue repair is based on original cell, only containing a small amount of fibrous tissue, local is without infecting, and hematoma or necrosis, tissue regeneration processes is rapid, and 26S Proteasome Structure and Function reparation is good.The II phase heal refer to that tissue defect is large, edge of wound is not whole, tremble out, cannot be neatly involutory, or with the healing of the wound infected.
Visible Chinese medicine gel of the present invention, preventing Be very effective in wound infection, contributes to wound healing.
In a word: the present invention has following beneficial effect: Chinese medicine gel of the present invention is very remarkable for the therapeutic effect of skin trauma, full side plays effect of heat-clearing and toxic substances removing, promoting blood circulation to remove blood stasis, reducing swelling and alleviating pain, promoting tissue regeneration and ulcer healing altogether, wound location blood circulation can be promoted, from outward appearance to inner essence promote that medicine permeates, absorbs in local organization, reaches dredging the meridian, blood circulation promoting and blood stasis dispelling and lenitive object; Medicine directly contacts wound, is conducive to wound clearing heat for detumescence, putrefaction-removing granulation-promoting, promotes wound healing; In addition Chinese medicine gel uniform and smooth of the present invention, easily coating after launching, holdup time long not skin tightening again, release is stable, good stability, without any side effects, drastically increases the compliance for the treatment of patients, improves the quality of life of patient.
Detailed description of the invention
Further describe the present invention below by way of detailed description of the invention, but the present invention is not limited only to following examples.Within the scope of the invention or not departing from content of the present invention, spirit and scope, the present invention is suitably improved, replaces the identical component of effect, will become apparent to those skilled in the art that they are all deemed to be included within scope of the present invention.
Embodiment 1
Gel forms: Acritamer 940 2.6%, hydroxypropyl emthylcellulose 1.4%, laurocapram 1.5%, Tween-80 2.5%, triethanolamine 1.4%, glycerol 7.5%, methyl hydroxybenzoate 0.3%, Chinese medicine clear paste 10%, and surplus is water;
Chinese medicine clear paste prescription: Herba Hyperici perforati 15 parts, Herba Oxytropis Myriophyllae 12 parts, Radix Zanthoxyli 10 parts, Herba Veronicae Serpyllifoliae 12 parts, Caulis Seu Folium Euonymi Fortunei 25 parts, Flos Hibisci Mutabilis 10 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 14 parts
Gel preparation method: get Herba Hyperici perforati, Herba Oxytropis Myriophyllae, Radix Zanthoxyli, Herba Veronicae Serpyllifoliae, Caulis Seu Folium Euonymi Fortunei, Flos Hibisci Mutabilis, the Pseudobulbus Bletillae (Rhizoma Bletillae), decocts with water 2 ~ 3 times, and each amount of water is 6 ~ 10 times of described crude drug weight, and decocting time is 1 ~ 2 hour, filters; Merging filtrate, leave standstill, getting supernatant concentration to relative density is 1.12 (60 DEG C record), adds ethanol and makes the volumn concentration of ethanol reach 75%, and after stirring, precipitate with ethanol leaves standstill; Get supernatant and reclaim ethanol, and to be concentrated into relative density be 1.12 (60 DEG C record), obtains described Chinese medicine clear paste;
Get surfactant Polysorbate-80, mix with gained Chinese medicine clear paste after thin up, obtain the first mixture; Macromolecular material Acritamer 940, hydroxypropyl emthylcellulose is fully swelling, add wetting agent glycerol, antiseptic methyl parahydroxybenzoate, be uniformly mixed, obtain the second mixture; First mixture, the second mixture and described penetration enhancer laurocapram are mixed, moisturizing, to recipe quantity, is uniformly mixed, with after triethanolamine adjust ph and get final product.
Embodiment 2
Gel forms: Acritamer 940 1.8%, hydroxypropyl emthylcellulose 1.6%, laurocapram 1.3%, Tween-80 25%, triethanolamine 1.7%, glycerol 8%, methyl parahydroxybenzoate 0.45%, Chinese medicine clear paste 7%, surplus is water.
Chinese medicine clear paste prescription: Herba Hyperici perforati 15 parts, Herba Oxytropis Myriophyllae 12 parts, Radix Zanthoxyli 10 parts, Herba Veronicae Serpyllifoliae 12 parts, Caulis Seu Folium Euonymi Fortunei 25 parts, Flos Hibisci Mutabilis 10 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 14 parts
Gel preparation method: get described raw material, decocts with water 2 ~ 3 times, and each amount of water is 6 ~ 10 times of described crude drug weight, and decocting time is 1 ~ 2 hour, filters; Merging filtrate, leave standstill, getting supernatant concentration to relative density is 1.10 (60 DEG C record), adds ethanol and makes the volumn concentration of ethanol reach 75%, and after stirring, precipitate with ethanol leaves standstill; Get supernatant and reclaim ethanol, and to be concentrated into relative density be 1.12 (60 DEG C record), obtains described Chinese medicine clear paste;
Get surfactant Polysorbate-80, mix with gained Chinese medicine clear paste after thin up, obtain the first mixture; Macromolecular material Acritamer 940, hydroxypropyl emthylcellulose is fully swelling, add wetting agent glycerol, antiseptic methyl parahydroxybenzoate, be uniformly mixed, obtain the second mixture; First mixture, the second mixture and described penetration enhancer laurocapram are mixed, moisturizing, to recipe quantity, is uniformly mixed, with after triethanolamine adjust ph and get final product.
Embodiment 3
Gel forms: Acritamer 940 3.0%, hydroxypropyl emthylcellulose 1.5%, laurocapram 2.2%, Tween-80 3.0%, triethanolamine 2.9%, glycerol 6.5%, methyl hydroxybenzoate 0.25%, Chinese medicine clear paste 12%, surplus is water.
Chinese medicine clear paste prescription: Herba Hyperici perforati 15 parts, Herba Oxytropis Myriophyllae 12 parts, Radix Zanthoxyli 10 parts, Herba Veronicae Serpyllifoliae 12 parts, Caulis Seu Folium Euonymi Fortunei 25 parts, Flos Hibisci Mutabilis 10 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 14 parts
Gel preparation method: get described raw material, decocts with water 2 ~ 3 times, and each amount of water is 6 ~ 10 times of described crude drug weight, and decocting time is 1 ~ 2 hour, filters; Merging filtrate, leave standstill, getting supernatant concentration to relative density is 1.15 (60 DEG C record), adds ethanol and makes the volumn concentration of ethanol reach 77%, and after stirring, precipitate with ethanol leaves standstill; Get supernatant and reclaim ethanol, and to be concentrated into relative density be 1.14 (60 DEG C record), obtains described Chinese medicine clear paste;
Get surfactant Polysorbate-80, mix with gained Chinese medicine clear paste after thin up, obtain the first mixture; Macromolecular material Acritamer 940, hydroxypropyl emthylcellulose is fully swelling, add wetting agent glycerol, antiseptic methyl parahydroxybenzoate, be uniformly mixed, obtain the second mixture; First mixture, the second mixture and described penetration enhancer laurocapram are mixed, moisturizing, to recipe quantity, is uniformly mixed, with after triethanolamine adjust ph and get final product.
Embodiment 4
Gel forms: Acritamer 940 2.0%, hydroxypropyl emthylcellulose 1.6%, laurocapram 2.0%, Tween-80 2.5%, triethanolamine 1.9%, glycerol 6.5%, methyl hydroxybenzoate 0.25%, Chinese medicine clear paste 10%, surplus is water.
Chinese medicine clear paste prescription: Herba Hyperici perforati 15 parts, Herba Oxytropis Myriophyllae 15 parts, Radix Zanthoxyli 12 parts, Herba Veronicae Serpyllifoliae 10 parts, Caulis Seu Folium Euonymi Fortunei 23 parts, Flos Hibisci Mutabilis 12 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 12 parts
Gel preparation method: with reference to embodiment 1-3.
Embodiment 5
Gel forms: Acritamer 940 3.5%, hydroxypropyl emthylcellulose 1.0%, laurocapram 2.5%, Tween-80 3.2%, triethanolamine 3.4%, glycerol 5.5%, methyl hydroxybenzoate 0.20%, Chinese medicine clear paste 13%, surplus is water.
Chinese medicine clear paste prescription: Herba Hyperici perforati 17 parts, Herba Oxytropis Myriophyllae 13 parts, Radix Zanthoxyli 13 parts, Herba Veronicae Serpyllifoliae 15 parts, Caulis Seu Folium Euonymi Fortunei 27 parts, Flos Hibisci Mutabilis 16 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 8 parts
Gel preparation method: with reference to embodiment 1-3.
Embodiment 6
Gel forms: Acritamer 940 3.0%, hydroxypropyl emthylcellulose 1.8%, laurocapram 2.5%, Tween-80 2.0%, triethanolamine 2.8%, glycerol 7.5%, methyl hydroxybenzoate 0.35%, Chinese medicine clear paste 12%, surplus is water.
Chinese medicine clear paste prescription: Herba Hyperici perforati 12 parts, Herba Oxytropis Myriophyllae 15 parts, Radix Zanthoxyli 12 parts, Herba Veronicae Serpyllifoliae 15 parts, Caulis Seu Folium Euonymi Fortunei 25 parts, Flos Hibisci Mutabilis 15 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 15 parts
Gel preparation method: with reference to embodiment 1-3.
Embodiment 7
Gel forms: Acritamer 940 2.5%, chitosan 2.0%, laurocapram 3.0%, Tween-80 4.5%, triethanolamine 1.5%, propylene glycol 10%, chlorobutanol 0.5%, Chinese medicine clear paste 10%, and surplus is water;
Chinese medicine clear paste prescription: Herba Hyperici perforati 10 parts, Herba Oxytropis Myriophyllae 15 parts, Radix Zanthoxyli 12 parts, Herba Veronicae Serpyllifoliae 10 parts, Caulis Seu Folium Euonymi Fortunei 23 parts, Flos Hibisci Mutabilis 15 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 12 parts
Gel preparation method: get described raw material, decocts with water 2 ~ 3 times, and each amount of water is 6 ~ 10 times of described crude drug weight, and decocting time is 1 ~ 2 hour, filters; Merging filtrate, leave standstill, getting supernatant concentration to relative density is 1.12 (60 DEG C record), adds ethanol and makes the volumn concentration of ethanol reach 73%, and after stirring, precipitate with ethanol leaves standstill; Get supernatant and reclaim ethanol, and to be concentrated into relative density be 1.15 (60 DEG C record), obtains described Chinese medicine clear paste;
Get surfactant Polysorbate-80, mix with gained Chinese medicine clear paste after thin up, obtain the first mixture; Macromolecular material Acritamer 940, chitosan is fully swelling, add wetting agent propylene glycol, antiseptic chlorobutanol, be uniformly mixed, obtain the second mixture; First mixture, the second mixture and described penetration enhancer laurocapram are mixed, moisturizing, to recipe quantity, is uniformly mixed, after adjust ph and get final product.
Embodiment 8
Gel forms: sodium carboxymethyl cellulose 5.5%, hydroxypropyl emthylcellulose 1.5%, chitosan 1.0%, propylene glycol 14%, Tween-80 2.5%, benzoic acid 0.35%, Chinese medicine clear paste 9%, surplus is water.
Chinese medicine clear paste prescription: Herba Hyperici perforati 18 parts, Herba Oxytropis Myriophyllae 15 parts, Radix Zanthoxyli 12 parts, Herba Veronicae Serpyllifoliae 15 parts, Caulis Seu Folium Euonymi Fortunei 28 parts, Flos Hibisci Mutabilis 10 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10 parts
Gel preparation method: get described raw material, decocts with water 2 ~ 3 times, and each amount of water is 6 ~ 10 times of described crude drug weight, and decocting time is 1 ~ 2 hour, filters; Merging filtrate, leave standstill, getting supernatant concentration to relative density is 1.15 (60 DEG C record), adds ethanol and makes the volumn concentration of ethanol reach 75%, and after stirring, precipitate with ethanol leaves standstill; Get supernatant and reclaim ethanol, and to be concentrated into relative density be 1.13 (60 DEG C record), obtains described Chinese medicine clear paste;
Get surfactant Polysorbate-80, mix with gained Chinese medicine clear paste after thin up, obtain the first mixture; Macromolecular material sodium carboxymethyl cellulose, hydroxypropyl emthylcellulose, chitosan is fully swelling, add propylene glycol, benzoic acid, be uniformly mixed, obtain the second mixture; First mixture, the second mixture and described penetration enhancer are mixed, moisturizing, to recipe quantity, is uniformly mixed, and to obtain final product.
Embodiment 9
Gel forms: Carbopol 941 2.5%, sodium carboxymethyl cellulose 4.0%, ethanol 23%, Tween-80 3.5%, sodium hydroxide 2.5%, propylene glycol 10%, para hydroxybenzene methyl ethyl 0.5%, Chinese medicine clear paste 10%, and surplus is water;
Chinese medicine clear paste prescription: Herba Hyperici perforati 15 parts, Herba Oxytropis Myriophyllae 12 parts, Radix Zanthoxyli 10 parts, Herba Veronicae Serpyllifoliae 12 parts, Caulis Seu Folium Euonymi Fortunei 25 parts, Flos Hibisci Mutabilis 10 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 14 parts.
Gel preparation method: get described raw material, decocts with water 2 ~ 3 times, and each amount of water is 6 ~ 10 times of described crude drug weight, and decocting time is 1 ~ 2 hour, filters; Merging filtrate, leave standstill, getting supernatant concentration to relative density is 1.10 ~ 1.15 (60 DEG C record), adds ethanol and makes the volumn concentration of ethanol reach 70% ~ 80% (preferably 75%), and after stirring, precipitate with ethanol leaves standstill; Get supernatant and reclaim ethanol, and to be concentrated into relative density be 1.10 ~ 1.15 (60 DEG C record), obtains described Chinese medicine clear paste;
Get surfactant Polysorbate-80, mix with gained Chinese medicine clear paste after thin up, obtain the first mixture; Macromolecular material Carbopol 941, sodium carboxymethyl cellulose is fully swelling, add wetting agent propylene glycol, antiseptic para hydroxybenzene methyl ethyl, be uniformly mixed, obtain the second mixture; First mixture, the second mixture and described penetration enhancer ethanol are mixed, moisturizing, to recipe quantity, is uniformly mixed, after adjust ph and get final product.
Claims (10)
1. promote a Chinese medicine gel for skin wound healing, it is characterized in that the Chinese medicine clear paste comprising macromolecular material, penetration enhancer, surfactant, pH adjusting agent, wetting agent, antiseptic, water and be made up of following raw material: Herba Hyperici perforati, Herba Oxytropis Myriophyllae, Radix Zanthoxyli, Herba Veronicae Serpyllifoliae, Caulis Seu Folium Euonymi Fortunei, Flos Hibisci Mutabilis, the Pseudobulbus Bletillae (Rhizoma Bletillae);
Wherein: by weight percentage, macromolecular material 0.5-8%, penetration enhancer 1-28%, surfactant 1-3.5%, pH adjusting agent 0.5-5%, wetting agent 6-10%, antiseptic 0.2-0.7%, Chinese medicine clear paste 5-15%, surplus is water.
2. Chinese medicine gel as claimed in claim 1, is characterized in that described Chinese medicine clear paste is made up of the crude drug of following weight parts: Herba Hyperici perforati 9-19 part, Herba Oxytropis Myriophyllae 8-18 part, Radix Zanthoxyli 5-15 part, Herba Veronicae Serpyllifoliae 5-15 part, Caulis Seu Folium Euonymi Fortunei 15-35 part, Flos Hibisci Mutabilis 8-18 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 6-16 part.
3. Chinese medicine gel as claimed in claim 2, is characterized in that described Chinese medicine clear paste is made up of the crude drug of following preferred weight part: Herba Hyperici perforati 12-17 part, Herba Oxytropis Myriophyllae 11-15 part, Radix Zanthoxyli 8-13 part, Herba Veronicae Serpyllifoliae 10-15 part, Caulis Seu Folium Euonymi Fortunei 23-28 part, Flos Hibisci Mutabilis 10-15 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 10-15 part.
4. Chinese medicine gel as claimed in claim 3, is characterized in that described Chinese medicine clear paste is made up of the crude drug of following preferred weight part: Herba Hyperici perforati 15 parts, Herba Oxytropis Myriophyllae 12 parts, Radix Zanthoxyli 10 parts, Herba Veronicae Serpyllifoliae 12 parts, Caulis Seu Folium Euonymi Fortunei 25 parts, Flos Hibisci Mutabilis 10 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 14 parts.
5. Chinese medicine gel as claimed in claim 1, is characterized in that described high-molecular matrix material is the combination in any of one of them or they of carbomer, chitosan, hydroxypropyl emthylcellulose, methylcellulose, sodium carboxymethyl cellulose.
6. Chinese medicine gel as claimed in claim 5, is characterized in that described high-molecular matrix material is Acritamer 940 and hydroxypropyl emthylcellulose.
7. Chinese medicine gel as claimed in claim 1, is characterized in that described penetration enhancer is the combination in any of one of them or they of laurocapram, propylene glycol, ethanol; Described surfactant is one of poly yamanashi esters, polyoxyethylene fatty acid ester class, polyoxyethylene aliphatic alcohol ether class or their combination in any; Described wetting agent is one of glycerol, propylene glycol or their combination; Described antiseptic can be the combination in any of benzoic acid, sodium benzoate, chlorobutanol, methyl hydroxybenzoate, ethyl hydroxybenzoate or butyl ester one of them or they.
8. Chinese medicine gel as claimed in claim 7, is characterized in that described described wetting agent is glycerol; Described antiseptic is methyl parahydroxybenzoate; Described penetration enhancer is laurocapram; Described surfactant is Tween-80.
9. Chinese medicine gel as claimed in claim 1, it is characterized in that, by weight percentage, comprise Acritamer 940 1.5-3.5%, hydroxypropyl emthylcellulose 1.0-2.0%, laurocapram 1-3%, Tween-80 1-3.5%, pH adjusting agent 1.5-3.5%, glycerol 6-10%, methyl hydroxybenzoate 0.2-0.5%, Chinese medicine clear paste 5-15%, surplus is water.
10. the Chinese medicine gel as described in claim 1-9, is characterized in that preparation method comprises the following steps:
Get Herba Hyperici perforati, Herba Oxytropis Myriophyllae, Radix Zanthoxyli, Herba Veronicae Serpyllifoliae, Caulis Seu Folium Euonymi Fortunei, Flos Hibisci Mutabilis, the Pseudobulbus Bletillae (Rhizoma Bletillae), decoct with water 2 ~ 3 times, each amount of water is 6 ~ 10 times of described crude drug weight, and decocting time is 1 ~ 2 hour, filters; Merging filtrate, leave standstill, getting supernatant concentration to relative density is 1.10 ~ 1.15 (60 DEG C record), adds ethanol and makes the volumn concentration of ethanol reach 70% ~ 80% (preferably 75%), and after stirring, precipitate with ethanol leaves standstill; Get supernatant and reclaim ethanol, and to be concentrated into relative density be 1.10 ~ 1.15 (60 DEG C record), obtains described Chinese medicine clear paste;
Get surfactant, mix with gained Chinese medicine clear paste after thin up, obtain the first mixture; Macromolecular material is fully swelling, add wetting agent, antiseptic, be uniformly mixed, obtain the second mixture; First mixture, the second mixture and described penetration enhancer are mixed, moisturizing, to recipe quantity, is uniformly mixed, after adjust ph and get final product.
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| CN110639055A (en) * | 2019-11-07 | 2020-01-03 | 广州市福托康生物科技有限公司 | Wound care ointment and preparation method thereof |
| CN111921005A (en) * | 2020-08-29 | 2020-11-13 | 山东百多安医疗器械股份有限公司 | Preparation method of hemostatic and antibacterial dressing containing herba Cephalanoploris extract |
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