CN105214028A - A kind of pharmaceutical composition is for the preparation of the purposes in treatment amenorrhea medicine - Google Patents
A kind of pharmaceutical composition is for the preparation of the purposes in treatment amenorrhea medicine Download PDFInfo
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Abstract
The invention belongs to the field of Chinese medicines, relate to a kind of pharmaceutical composition for the preparation of the purposes in treatment amenorrhea medicine.This pharmaceutical composition is prepared from by the raw material of following parts by weight: Radix Polygoni Multiflori 6-12 part, Rhizoma Dioscoreae 5-13 part, Radix Ophiopogonis 6-16 part, Folium Artemisiae Argyi 6-28 part, Rhizoma Corydalis 5-8 part, Radix Angelicae Sinensis 6-11 part, Fructus Toosendan 5-8 part, Radix Linderae 4-10 part, Cortex Moutan 5-12 part, Fructus Hordei Germinatus 10-14 part, Fructus Mori 6-12 part, Cortex Cinnamomi 4-8 part, Pericarpium Citri Reticulatae Viride 4-8 part, Radix Et Rhizoma Rhei 10-18 part, Radix Paeoniae Alba 6-16 part, Rhizoma Curcumae 7-14 part, Concha Ostreae 10-16 part, Rhizoma Zingiberis 2-6 part, Poria 10-15 part and Radix Glycyrrhizae 4-12 part.This pharmaceutical composition has effect of blood circulation promoting and blood stasis dispelling, menstruction regulating and pain relieving, nourishing YIN and moistening the lung, clearing away heart-fire for tranquillization and removing pathogenic heat from blood and toxic substance from the body, also has compatibility science, and curative effect is rapid, and cure rate is high, low cost and other advantages.
Description
Technical field
The invention belongs to the field of Chinese medicines, particularly relate to a kind of pharmaceutical composition for the preparation of the purposes in treatment amenorrhea medicine.
Background technology
Amenorrhea is symptom common in gynaecopathia, can be caused by various different reason.Usually amenorrhea is divided into constitutional and Secondary cases two kinds.All persons that do not pass through yet over 18 years old are called primary amenorrhea; After menarche, in any time before normal menopause (gestation or age of sucking except), menstruation apolipsis is called secondary amenorrhea more than 6 months persons.Menstruation causes endometrical cycle to come off by the periodic adjustment of hypothalamic-pituitary-ovarian axis to be formed, therefore any organic or functional change occurred on the links in hypothalamus, hypophysis, ovary and reproductive tract particularly uterus, all may cause amenorrhea.Organic and the functional exception of other endocrine gland, also may affect menstruation so that amenorrhea occurs.
In recent years, along with the increase of life stress, just there is the phenomenon of amenorrhea too early in a lot of women before menopause.Amenorrhea is very large on the impact of women's physical and mental health.Amenorrhea is a kind of gynecological common disease, clinical manifestation: from ischomenia, association's abdominal distention and pain symptom is the most outstanding, the traditional Chinese medical science is thought: the generation of amenorrhea, void is had to have reality, many with empty person, reality person is few, void person is due to congenital defect or the fecund exhaustion due to sexual indulgence day after tomorrow, prolonged illness serious disease, improper diet and overtiredness, the factor such as to worry too much of being worried causes kidney qi weakness, or deficient qi and blood, or deficiency of YIN blood is dry, depletion of blood can under, and cause amenorrhea due to blood depletion, reality person is due to internal injury caused by excess of seven emotions or experience cold and heat damp or ferritic obesity, excessive phlegm wets more, cause qi depression to blood stasis, or stagnation of phlegm-damp, blockage of vessel, menses must not be descending and cause blood every amenorrhea.According to theory of Chinese medical science, for the pathogeny of amenorrhea, with depressed liver-energy dispersing and QI regulating, benefiting vital QI and blood, dispelling cold by warming the meridian, blood circulation promoting and blood stasis dispelling for the rule for the treatment of, carry out dialectical prescription compatibility, to reach the object for the treatment of both the principal and secondary aspects of a disease.At present, the medicine for the treatment of amenorrhea is also a lot, but there is the deficiencies such as curative effect instability, treatment time is long, side effect is large.
Chinese patent 201310308011.1 discloses a kind of Chinese medicine composition for the treatment of amenorrhea, this Chinese medicine composition is prepared from by the raw material of following weight portion: Radix Codonopsis 20-30 part, Radix Rehmanniae Preparata 20-30 part, Herba Epimedii 20-30 part, Folium Photiniae (Folium Photiniae serrulatae) 20-30 part, Radix Angelicae Sinensis 20-30 part, Radix Paeoniae Alba 20-30 part, Herba Leonuri 10-20 part, Radix Astragali 10-15 part, Cornu Cervi Degelatinatum 10-15 part, Rhizoma Atractylodis Macrocephalae 5-15 part, Poria 5-15 part, Radix Rhapontici 5-15 part, Fructus Liquidambaris 5-15 part, Fructus Leonuri 5-15 part, Rhizoma Cyperi 5-15 part, Ramulus Cinnamomi 5-15 part, Fructus Lycii 5-15 part, Fructus Ligustri Lucidi 5-15 part, Semen Cuscutae 5-15 part, Fructus Rubi 5-15 part, Herba Ephedrae 5-15 part, Cortex Mori 5-15 part, Radix Achyranthis Bidentatae 5-15 part, Flos Carthami 5-15 part, Radix Bupleuri 5-15 part, Herba Lycopi 5-15 part, Radix Curcumae 5-15 part, Radix Glycyrrhizae 5-15 part, Eupolyphaga Seu Steleophaga 3-9 part, Hirudo 3-9 part, Radix Platycodonis 3-9 part, Rhizoma Chuanxiong 3-9 part.This Chinese medicine composition has stable curative effect, treatment time is short, side effect is little effect, but effect is not very remarkable in dispersing cold for relieving pain.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of pharmaceutical composition for the preparation of the purposes in treatment amenorrhea medicine, this pharmaceutical composition has effect of blood circulation promoting and blood stasis dispelling, menstruction regulating and pain relieving, nourishing YIN and moistening the lung, clearing away heart-fire for tranquillization and removing pathogenic heat from blood and toxic substance from the body, also there is compatibility science, curative effect is rapid, cure rate is high, low cost and other advantages.In addition, the present invention also provides corresponding manufacturing process to be made and facilitate easy-to-use preparation under the prerequisite ensureing curative effect by this pharmaceutical composition.
Pharmaceutical composition of the present invention is prepared from by the raw material of following parts by weight:
Radix Polygoni Multiflori 6-12 part, Rhizoma Dioscoreae 5-13 part, Radix Ophiopogonis 6-16 part, Folium Artemisiae Argyi 6-28 part, Rhizoma Corydalis 5-8 part, Radix Angelicae Sinensis 6-11 part, Fructus Toosendan 5-8 part, Radix Linderae 4-10 part, Cortex Moutan 5-12 part, Fructus Hordei Germinatus 10-14 part, Fructus Mori 6-12 part, Cortex Cinnamomi 4-8 part, Pericarpium Citri Reticulatae Viride 4-8 part, Radix Et Rhizoma Rhei 10-18 part, Radix Paeoniae Alba 6-16 part, Rhizoma Curcumae 7-14 part, Concha Ostreae 10-16 part, Rhizoma Zingiberis 2-6 part, Poria 10-15 part and Radix Glycyrrhizae 4-12 part.
Further, described pharmaceutical composition is prepared from by the raw material of following parts by weight:
Radix Polygoni Multiflori 6 parts, Rhizoma Dioscoreae 5 parts, Radix Ophiopogonis 6 parts, Folium Artemisiae Argyi 6 parts, Rhizoma Corydalis 5 parts, Radix Angelicae Sinensis 6 parts, Fructus Toosendan 5 parts, the Radix Linderae 4, Cortex Moutan 5 parts, 10 parts, Fructus Hordei Germinatus, Fructus Mori 6 parts, Cortex Cinnamomi 4 parts, 4 parts, Pericarpium Citri Reticulatae Viride, Radix Et Rhizoma Rhei 10 parts, the Radix Paeoniae Alba 6 parts, Rhizoma Curcumae 7 parts, Concha Ostreae 10 parts, Rhizoma Zingiberis 2 parts, 10 parts, Poria and 4 parts, Radix Glycyrrhizae.
Further, described pharmaceutical composition is prepared from by the raw material of following parts by weight:
Radix Polygoni Multiflori 12 parts, Rhizoma Dioscoreae 3 parts, Radix Ophiopogonis 16 parts, Folium Artemisiae Argyi 28 parts, Rhizoma Corydalis 8 parts, Radix Angelicae Sinensis 11 parts, Fructus Toosendan 8 parts, the Radix Linderae 10 parts, Cortex Moutan 12 parts, 14 parts, Fructus Hordei Germinatus, Fructus Mori 12 parts, Cortex Cinnamomi 8 parts, 8 parts, Pericarpium Citri Reticulatae Viride, Radix Et Rhizoma Rhei 18 parts, the Radix Paeoniae Alba 16 parts, Rhizoma Curcumae 14 parts, Concha Ostreae 16 parts, Rhizoma Zingiberis 6 parts, 15 parts, Poria and 12 parts, Radix Glycyrrhizae.
Further, described pharmaceutical composition is prepared from by the raw material of following parts by weight:
Radix Polygoni Multiflori 10 parts, Rhizoma Dioscoreae 8 parts, Radix Ophiopogonis 12 parts, Folium Artemisiae Argyi 18 parts, Rhizoma Corydalis 6 parts, Radix Angelicae Sinensis 8 parts, Fructus Toosendan 6 parts, the Radix Linderae 6 parts, Cortex Moutan 10 parts, 12 parts, Fructus Hordei Germinatus, Fructus Mori 8 parts, Cortex Cinnamomi 6 parts, 6 parts, Pericarpium Citri Reticulatae Viride, Radix Et Rhizoma Rhei 16 parts, the Radix Paeoniae Alba 12 parts, Rhizoma Curcumae 8 parts, Concha Ostreae 10 parts, Rhizoma Zingiberis 4 parts, 12 parts, Poria and 8 parts, Radix Glycyrrhizae.
Further, described pharmaceutical composition is made into capsule, tablet, powder, granule or pill.
Accordingly, the preparation method of described pharmaceutical composition comprises following step:
S1 gets Radix Ophiopogonis and pulverizes, be placed in supercritical carbon dioxide extraction apparatus, adding Radix Ophiopogonis coarse powder total amount 2-3 times concentration is the ethanol of 75-85%, regulation and control carbon dioxide flow is 16-22L/h, extracting pressure is 18-25MPa, extraction temperature is 55-65 DEG C, and extraction time is 2-3h, and decompression separation obtains Radix Ophiopogonis extract;
S2 gets Radix Polygoni Multiflori, Rhizoma Dioscoreae, Folium Artemisiae Argyi, Rhizoma Corydalis, Radix Angelicae Sinensis, Fructus Toosendan, the Radix Linderae, Cortex Moutan, Fructus Hordei Germinatus, Fructus Mori, Cortex Cinnamomi, Pericarpium Citri Reticulatae Viride, Radix Et Rhizoma Rhei, the Radix Paeoniae Alba, Rhizoma Curcumae, Concha Ostreae, Rhizoma Zingiberis, Poria and Radix Glycyrrhizae and pulverizes, add water heating and refluxing extraction 2-3 time of above-mentioned coarse powder total amount 10-15 times amount, each 2-3 hour, filter, merging filtrate, obtains aqueous extract;
The aqueous extract that step S2 obtains by S3 is evaporated at 60 DEG C and surveys the extractum that relative density is 1.15-1.25, the mass fraction adding above-mentioned extractum total amount 7-10% at 55-65 DEG C is the chitosan gum liquid solution of 0.8-1.2%, stir 5-10 minute, leave standstill 12-24 hour at normal temperatures, the centrifugal 10-15 minute of 1000-1200r/min, gets supernatant, mixes with the Radix Ophiopogonis extract that step S1 obtains, and be evaporated at 60 DEG C and survey the extractum that relative density is 1.20-1.35, to obtain final product.
Source, the nature and flavor of the present invention's component used, return through and effect:
Radix Polygoni Multiflori: this product is the dried root of polygonum multiflorum thunb; Bitter in the mouth, sweet, puckery, warm in nature; Return liver, the heart, kidney channel; Removing toxic substances, eliminating carbuncle, loosening bowel to relieve constipation.
Rhizoma Dioscoreae: be Dioscoreaceae plant Rhizoma Dioscoreae dry rhizome; Sweet, flat; Return spleen, lung, kidney channel; Spleen reinforcing, support lung, reinforce the kidney, benefit essence.
Radix Ophiopogonis: be herbal of Liliaceae Ophiopogon perennial evergreen; Sweet, micro-hardship, is slightly cold; GUIXIN, lung, stomach warp; YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.
Folium Artemisiae Argyi: be the dried leaves of feverfew Chinese mugwort; Its nature and flavor acrid, bitter, warm, returns liver,spleen,kidney warp; Folium Artemisiae Argyi has the effects such as warming the meridian for stopping bleeding, dispersing cold for relieving pain, regulating menstruation are antiabortive, removing damp to relieve itching, dredge the meridian passage.
Rhizoma Corydalis: this product is the dry tuber of papaveraceae plant corydalis; Acrid in the mouth, hardship, warm in nature; Return liver, spleen channel; Invigorate blood circulation, promoting the circulation of QI, pain relieving.
Radix Angelicae Sinensis: this product is the dry root of umbelliferae angelica; Sweet in the mouth, pungent, warm in nature; Return liver, the heart, spleen channel; Inrigorating qi and promoting blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.
Fructus Toosendan: this product is the dry mature fruit of Meliaceae plant Fructus Toosendan; Bitter in the mouth, cold in nature; Return liver, small intestinal, urinary bladder channel; Soothing liver-QI promoting the circulation of QI to relieve pain.
The Radix Linderae: this product is the dried root of the canella Radix Linderae; Acrid in the mouth, warm in nature; Return lung, spleen, kidney, urinary bladder channel; Pleasant pain relieving, warming kidney for dispelling cold.
Cortex Moutan: this product is the dry root bark of ranunculaceae peony; Bitter in the mouth, pungent, cold nature; GUIXIN, liver, kidney channel; Clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling.
Fructus Hordei Germinatus: this product is that the mature fruit of grass Fructus Hordei Vulgaris obtains through drying of germinateing; Sweet in the mouth, property is put down; Return spleen, stomach warp; Promote qi circulation digestion promoting, spleen benefiting and stimulating the appetite.
Fructus Mori: this product is the mature fruit of mulberry; Sweet in the mouth acid, cold in nature; Enter lung, liver, kidney, large intestine channel; The liver and the kidney tonifying, intestine moistening of promoting the production of body fluid, black hair improving eyesight, quench the thirst removing toxic substances, looks improving and the skin nourishing.
Cortex Cinnamomi: this product is the dry bark of canella Cortex Cinnamomi; Acrid in the mouth, sweet, extremely hot in nature; Return kidney, spleen, the heart, Liver Channel; Mend fire supporing yang, let the fire back to its origin, dispersing cold for relieving pain, promoting blood circulation to restore menstrual flow.
Pericarpium Citri Reticulatae Viride: this product is the dry young fruit of rutaceae orange and variety thereof or the peel of immature fruit; Bitter in the mouth, pungent, warm in nature; Return liver, gallbladder, stomach warp; Soothing the liver dispelling the stagnated QI, removing food stagnancyization is stagnant.
Radix Et Rhizoma Rhei: this product is the dry root and rhizome of polygonaceae plant Radix Et Rhizoma Rhei; Bitter in the mouth, cold in nature; Return spleen, stomach, large intestine, liver, pericardium channel; Purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation.
The Radix Paeoniae Alba: this product is the dry root of ranunculaceae plant Radix Paeoniae; Bitter in the mouth, acid, cold nature; Return liver, spleen channel; Suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, astringing YIN to stop sweating.
Rhizoma Curcumae: this product is the dry rhizome of zingiberaceous plant Rhizoma Curcumae; Acrid in the mouth, hardship, warm in nature; Return liver, spleen channel; Circulation of qi promoting removing blood stasis, removing food stagnancy pain relieving.
Concha Ostreae: this product is the shell of Ostreidae animal Concha Ostreae; Salty in the mouth, cold nature; Return liver, gallbladder, kidney channel; Tranquillization with heavy prescription, YANG hyperactivity suppressing nourishing YIN, hard masses softening and resolving.
Rhizoma Zingiberis: this product is the dry rhizome of zingiber; Acrid in the mouth, hot in nature; Return spleen, stomach, kidney, the heart, lung meridian; Warming spleen and stomach for dispelling cold, recuperating depleted YANG is promoted blood circulation, dampness expectorant.
Poria: this product is the dry sclerotia of On Polyporaceae Poria; Sweet in the mouth, light, property is put down; GUIXIN, lung, spleen, kidney channel; Promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.
Radix Glycyrrhizae: this product is the dry root of glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L..Sweet in the mouth, property is put down; GUIXIN, lung, spleen, stomach warp; Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.
Compared with prior art, the present invention has following technical advantage:
1, pharmaceutical composition of the present invention is compared with the medicine of other treatment amenorrhea, in blood circulation promoting and blood stasis dispelling, menstruction regulating and pain relieving, nourishing YIN and moistening the lung, clearing away heart-fire for tranquillization and removing pathogenic heat from blood and toxic substance from the body, has significant effect.
2, compared with the chemotherapeutic agent of Current therapeutic amenorrhea, pharmaceutical composition of the present invention is natural pure Chinese medicinal preparation, untoward reaction and side effect significantly reduce, and pharmaceutical composition effect of the present invention is comprehensive, medication effect is better, efficiently solve the morbidity root of amenorrhea, and improve the quality of life of patient.
3, pharmaceutical composition of the present invention also has compatibility science, and curative effect is rapid, and cure rate is high, low cost and other advantages.
Detailed description of the invention
It will be understood by those skilled in the art that technology disclosed in following examples represents the technology playing good action in the practice of the invention of the present inventor's discovery.But, many changes can be made in disclosed specific embodiments, and still obtain same or analogous result, and not depart from the spirit and scope of the present invention.
embodiment 1:
The embodiment of the present invention 1 pharmaceutical composition is prepared from by the raw material of following parts by weight: Radix Polygoni Multiflori 6 parts, Rhizoma Dioscoreae 5 parts, Radix Ophiopogonis 6 parts, Folium Artemisiae Argyi 6 parts, Rhizoma Corydalis 5 parts, Radix Angelicae Sinensis 6 parts, Fructus Toosendan 5 parts, the Radix Linderae 4, Cortex Moutan 5 parts, 10 parts, Fructus Hordei Germinatus, Fructus Mori 6 parts, Cortex Cinnamomi 4 parts, 4 parts, Pericarpium Citri Reticulatae Viride, Radix Et Rhizoma Rhei 10 parts, the Radix Paeoniae Alba 6 parts, Rhizoma Curcumae 7 parts, Concha Ostreae 10 parts, Rhizoma Zingiberis 2 parts, 10 parts, Poria and 4 parts, Radix Glycyrrhizae.
Preparation method is as follows:
S1 gets Radix Ophiopogonis and pulverizes, and be placed in supercritical carbon dioxide extraction apparatus, adding coarse powder total amount Radix Ophiopogonis 2 times of concentration is the ethanol of 75%, regulation and control carbon dioxide flow is 16L/h, and extracting pressure is 18MPa, and extraction temperature is 55 DEG C, extraction time is 2h, and decompression separation obtains Radix Ophiopogonis extract;
S2 gets Radix Polygoni Multiflori, Rhizoma Dioscoreae, Folium Artemisiae Argyi, Rhizoma Corydalis, Radix Angelicae Sinensis, Fructus Toosendan, the Radix Linderae, Cortex Moutan, Fructus Hordei Germinatus, Fructus Mori, Cortex Cinnamomi, Pericarpium Citri Reticulatae Viride, Radix Et Rhizoma Rhei, the Radix Paeoniae Alba, Rhizoma Curcumae, Concha Ostreae, Rhizoma Zingiberis, Poria and Radix Glycyrrhizae and pulverizes, add the water heating and refluxing extraction 2 times of above-mentioned coarse powder total amount 10 times amount, each 2 hours, filter, merging filtrate, obtains aqueous extract;
The aqueous extract that step S2 obtains by S3 is evaporated at 60 DEG C and surveys the extractum that relative density is 1.15, the mass fraction adding above-mentioned extractum total amount 7% at 55 DEG C is the chitosan gum liquid solution of 0.8%, stir 5 minutes, leave standstill 12 hours at normal temperatures, centrifugal 10 minutes of 1000r/min, gets supernatant, mix with the Radix Ophiopogonis extract that step S1 obtains, and be evaporated at 60 DEG C and survey the extractum that relative density is 1.20, add corresponding adjuvant, make capsule.
embodiment 2:
The embodiment of the present invention 2 pharmaceutical composition is prepared from by the raw material of following parts by weight: Radix Polygoni Multiflori 12 parts, Rhizoma Dioscoreae 3 parts, Radix Ophiopogonis 16 parts, Folium Artemisiae Argyi 28 parts, Rhizoma Corydalis 8 parts, Radix Angelicae Sinensis 11 parts, Fructus Toosendan 8 parts, the Radix Linderae 10 parts, Cortex Moutan 12 parts, 14 parts, Fructus Hordei Germinatus, Fructus Mori 12 parts, Cortex Cinnamomi 8 parts, 8 parts, Pericarpium Citri Reticulatae Viride, Radix Et Rhizoma Rhei 18 parts, the Radix Paeoniae Alba 16 parts, Rhizoma Curcumae 14 parts, Concha Ostreae 16 parts, Rhizoma Zingiberis 6 parts, 15 parts, Poria and 12 parts, Radix Glycyrrhizae.
S1 gets Radix Ophiopogonis and pulverizes, and be placed in supercritical carbon dioxide extraction apparatus, adding coarse powder total amount Radix Ophiopogonis 2 times of concentration is the ethanol of 80%, regulation and control carbon dioxide flow is 20L/h, and extracting pressure is 22MPa, and extraction temperature is 60 DEG C, extraction time is 2h, and decompression separation obtains Radix Ophiopogonis extract;
S2 gets Radix Polygoni Multiflori, Rhizoma Dioscoreae, Folium Artemisiae Argyi, Rhizoma Corydalis, Radix Angelicae Sinensis, Fructus Toosendan, the Radix Linderae, Cortex Moutan, Fructus Hordei Germinatus, Fructus Mori, Cortex Cinnamomi, Pericarpium Citri Reticulatae Viride, Radix Et Rhizoma Rhei, the Radix Paeoniae Alba, Rhizoma Curcumae, Concha Ostreae, Rhizoma Zingiberis, Poria and Radix Glycyrrhizae and pulverizes, add the water heating and refluxing extraction 2 times of above-mentioned coarse powder total amount 12 times amount, each 2 hours, filter, merging filtrate, obtains aqueous extract;
The aqueous extract that step S2 obtains by S3 is evaporated at 60 DEG C and surveys the extractum that relative density is 1.20, the mass fraction adding above-mentioned extractum total amount 8% at 60 DEG C is the chitosan gum liquid solution of 1.0%, stir 8 minutes, leave standstill 18 hours at normal temperatures, centrifugal 12 minutes of 1100r/min, gets supernatant, mix with the Radix Ophiopogonis extract that step S1 obtains, and be evaporated at 60 DEG C and survey the extractum that relative density is 1.30, add corresponding adjuvant, make tablet.
embodiment 3:
The embodiment of the present invention 3 pharmaceutical composition is prepared from by the raw material of following parts by weight: Radix Polygoni Multiflori 10 parts, Rhizoma Dioscoreae 8 parts, Radix Ophiopogonis 12 parts, Folium Artemisiae Argyi 18 parts, Rhizoma Corydalis 6 parts, Radix Angelicae Sinensis 8 parts, Fructus Toosendan 6 parts, the Radix Linderae 6 parts, Cortex Moutan 10 parts, 12 parts, Fructus Hordei Germinatus, Fructus Mori 8 parts, Cortex Cinnamomi 6 parts, 6 parts, Pericarpium Citri Reticulatae Viride, Radix Et Rhizoma Rhei 16 parts, the Radix Paeoniae Alba 12 parts, Rhizoma Curcumae 8 parts, Concha Ostreae 10 parts, Rhizoma Zingiberis 4 parts, 12 parts, Poria and 8 parts, Radix Glycyrrhizae.
S1 gets Radix Ophiopogonis and pulverizes, and be placed in supercritical carbon dioxide extraction apparatus, adding coarse powder total amount Radix Ophiopogonis 3 times of concentration is the ethanol of 85%, regulation and control carbon dioxide flow is 22L/h, and extracting pressure is 25MPa, and extraction temperature is 65 DEG C, extraction time is 3h, and decompression separation obtains Radix Ophiopogonis extract;
S2 gets Radix Polygoni Multiflori, Rhizoma Dioscoreae, Folium Artemisiae Argyi, Rhizoma Corydalis, Radix Angelicae Sinensis, Fructus Toosendan, the Radix Linderae, Cortex Moutan, Fructus Hordei Germinatus, Fructus Mori, Cortex Cinnamomi, Pericarpium Citri Reticulatae Viride, Radix Et Rhizoma Rhei, the Radix Paeoniae Alba, Rhizoma Curcumae, Concha Ostreae, Rhizoma Zingiberis, Poria and Radix Glycyrrhizae and pulverizes, add the water heating and refluxing extraction 3 times of above-mentioned coarse powder total amount 15 times amount, each 3 hours, filter, merging filtrate, obtains aqueous extract;
The aqueous extract that step S2 obtains by S3 is evaporated at 60 DEG C and surveys the extractum that relative density is 1.25, the mass fraction adding above-mentioned extractum total amount 10% at 65 DEG C is the chitosan gum liquid solution of 1.2%, stir 10 minutes, leave standstill 24 hours at normal temperatures, centrifugal 15 minutes of 1200r/min, gets supernatant, mix with the Radix Ophiopogonis extract that step S1 obtains, and be evaporated at 60 DEG C and survey the extractum that relative density is 1.35, add corresponding adjuvant, make pill.
pharmaceutical composition of the present invention is to the observation of curative effect of amenorrhea clinical volunteers patient
One, diagnostic criteria
(1) over 18 one full year of life woman, menstruation is menophania person not yet, belongs to primary amenorrhea;
(2) woman has passed through and has interrupted more than 3 months persons, belongs to secondary amenorrhea;
(3) must differentiate mutually with physiological menolipsis such as trimester of pregnancy, age of sucking, menopause.
Two, criterion of therapeutical effect
(1) cure: menstrual onset, continuous more than 3 times menorrheas;
(2) effective: menstruation recovery is risen, but menstrual cycle is abnormal;
(3) invalid; Menstruation is risen not yet.
Three, clinical trial
1, physical data
140 selected amenorrhea clinical volunteers patients are divided into 2 groups at random, and often organize 70 people, be respectively treatment group and matched group, the age is 18-48 year, and respectively organize the influence factor such as age, symptom, through statistical procedures, there was no significant difference, meets a point set condition.
2, Therapeutic Method
Treatment group: take the pill that embodiment 3 prepares, each 6g, every day 2 times, serve on 2 months;
Matched group: take pill for invigorating circulation of blood and regulating menstruation (Guangxi Wuzhou Sanhe Pharmaceutical Co., Ltd, accurate word Z45020639, the 9g*10 ball/box of traditional Chinese medicines), 1 ball, 2 times on the one, serve on 2 months.
3, therapeutic outcome, as shown in table 1:
The cure rate of pharmaceutical composition of the present invention is all greater than 80%, and total effective rate is all greater than 90%, much larger than cure rate and the total effective rate of matched group, visible, pharmaceutical composition good effect of the present invention, and cure rate is high, can as the drug use for the treatment of amenorrhea.
Owing to describing the present invention by above preferred embodiment, in spirit of the present invention and/or scope, any for replacement/of the present invention or combination implement the present invention, be all apparent for a person skilled in the art, and be included among the present invention.
Claims (6)
1. pharmaceutical composition is for the preparation of the purposes in treatment amenorrhea medicine, and it is characterized in that, described pharmaceutical composition is prepared from by the raw material of following parts by weight:
Radix Polygoni Multiflori 6-12 part, Rhizoma Dioscoreae 5-13 part, Radix Ophiopogonis 6-16 part, Folium Artemisiae Argyi 6-28 part, Rhizoma Corydalis 5-8 part, Radix Angelicae Sinensis 6-11 part, Fructus Toosendan 5-8 part, Radix Linderae 4-10 part, Cortex Moutan 5-12 part, Fructus Hordei Germinatus 10-14 part, Fructus Mori 6-12 part, Cortex Cinnamomi 4-8 part, Pericarpium Citri Reticulatae Viride 4-8 part, Radix Et Rhizoma Rhei 10-18 part, Radix Paeoniae Alba 6-16 part, Rhizoma Curcumae 7-14 part, Concha Ostreae 10-16 part, Rhizoma Zingiberis 2-6 part, Poria 10-15 part and Radix Glycyrrhizae 4-12 part.
2. purposes as claimed in claim 1, it is characterized in that, described pharmaceutical composition is prepared from by the raw material of following parts by weight:
Radix Polygoni Multiflori 6 parts, Rhizoma Dioscoreae 5 parts, Radix Ophiopogonis 6 parts, Folium Artemisiae Argyi 6 parts, Rhizoma Corydalis 5 parts, Radix Angelicae Sinensis 6 parts, Fructus Toosendan 5 parts, the Radix Linderae 4, Cortex Moutan 5 parts, 10 parts, Fructus Hordei Germinatus, Fructus Mori 6 parts, Cortex Cinnamomi 4 parts, 4 parts, Pericarpium Citri Reticulatae Viride, Radix Et Rhizoma Rhei 10 parts, the Radix Paeoniae Alba 6 parts, Rhizoma Curcumae 7 parts, Concha Ostreae 10 parts, Rhizoma Zingiberis 2 parts, 10 parts, Poria and 4 parts, Radix Glycyrrhizae.
3. purposes as claimed in claim 1, it is characterized in that, described pharmaceutical composition is prepared from by the raw material of following parts by weight:
Radix Polygoni Multiflori 12 parts, Rhizoma Dioscoreae 3 parts, Radix Ophiopogonis 16 parts, Folium Artemisiae Argyi 28 parts, Rhizoma Corydalis 8 parts, Radix Angelicae Sinensis 11 parts, Fructus Toosendan 8 parts, the Radix Linderae 10 parts, Cortex Moutan 12 parts, 14 parts, Fructus Hordei Germinatus, Fructus Mori 12 parts, Cortex Cinnamomi 8 parts, 8 parts, Pericarpium Citri Reticulatae Viride, Radix Et Rhizoma Rhei 18 parts, the Radix Paeoniae Alba 16 parts, Rhizoma Curcumae 14 parts, Concha Ostreae 16 parts, Rhizoma Zingiberis 6 parts, 15 parts, Poria and 12 parts, Radix Glycyrrhizae.
4. purposes as claimed in claim 1, it is characterized in that, described pharmaceutical composition is prepared from by the raw material of following parts by weight:
Radix Polygoni Multiflori 10 parts, Rhizoma Dioscoreae 8 parts, Radix Ophiopogonis 12 parts, Folium Artemisiae Argyi 18 parts, Rhizoma Corydalis 6 parts, Radix Angelicae Sinensis 8 parts, Fructus Toosendan 6 parts, the Radix Linderae 6 parts, Cortex Moutan 10 parts, 12 parts, Fructus Hordei Germinatus, Fructus Mori 8 parts, Cortex Cinnamomi 6 parts, 6 parts, Pericarpium Citri Reticulatae Viride, Radix Et Rhizoma Rhei 16 parts, the Radix Paeoniae Alba 12 parts, Rhizoma Curcumae 8 parts, Concha Ostreae 10 parts, Rhizoma Zingiberis 4 parts, 12 parts, Poria and 8 parts, Radix Glycyrrhizae.
5. the purposes as described in as arbitrary in claim 1-4, it is characterized in that, described pharmaceutical composition is made into capsule, tablet, powder, granule or pill.
6. the purposes as described in as arbitrary in claim 1-5, it is characterized in that, the preparation method of described pharmaceutical composition comprises following step:
S1 gets Radix Ophiopogonis and pulverizes, be placed in supercritical carbon dioxide extraction apparatus, adding Radix Ophiopogonis coarse powder total amount 2-3 times concentration is the ethanol of 75-85%, regulation and control carbon dioxide flow is 16-22L/h, extracting pressure is 18-25MPa, extraction temperature is 55-65 DEG C, and extraction time is 2-3h, and decompression separation obtains Radix Ophiopogonis extract;
S2 gets Radix Polygoni Multiflori, Rhizoma Dioscoreae, Folium Artemisiae Argyi, Rhizoma Corydalis, Radix Angelicae Sinensis, Fructus Toosendan, the Radix Linderae, Cortex Moutan, Fructus Hordei Germinatus, Fructus Mori, Cortex Cinnamomi, Pericarpium Citri Reticulatae Viride, Radix Et Rhizoma Rhei, the Radix Paeoniae Alba, Rhizoma Curcumae, Concha Ostreae, Rhizoma Zingiberis, Poria and Radix Glycyrrhizae and pulverizes, add water heating and refluxing extraction 2-3 time of above-mentioned coarse powder total amount 10-15 times amount, each 2-3 hour, filter, merging filtrate, obtains aqueous extract;
The aqueous extract that step S2 obtains by S3 is evaporated at 60 DEG C and surveys the extractum that relative density is 1.15-1.25, the mass fraction adding above-mentioned extractum total amount 7-10% at 55-65 DEG C is the chitosan gum liquid solution of 0.8-1.2%, stir 5-10 minute, leave standstill 12-24 hour at normal temperatures, the centrifugal 10-15 minute of 1000-1200r/min, gets supernatant, mixes with the Radix Ophiopogonis extract that step S1 obtains, and be evaporated at 60 DEG C and survey the extractum that relative density is 1.20-1.35, to obtain final product.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1203805A (en) * | 1998-06-04 | 1999-01-06 | 李胤良 | Health-care drink capable of preventing and curing menopathy |
| CN101829308A (en) * | 2010-07-01 | 2010-09-15 | 泰一和浦（北京）中医药研究院有限公司 | Traditional Chinese medicine combination for treating amenorrhea and preparation method thereof |
| CN104984297A (en) * | 2015-07-24 | 2015-10-21 | 青岛蓝盛洋医药生物科技有限责任公司 | Application of pharmaceutical composition in preparation of drugs for treating amenorrhea |
| CN105288538A (en) * | 2015-09-30 | 2016-02-03 | 叶宗耀 | Application of medicine composition for preparing medicine for treating amenorrhea |
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2015
- 2015-09-29 CN CN201510630763.9A patent/CN105214028A/en not_active Withdrawn
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1203805A (en) * | 1998-06-04 | 1999-01-06 | 李胤良 | Health-care drink capable of preventing and curing menopathy |
| CN101829308A (en) * | 2010-07-01 | 2010-09-15 | 泰一和浦（北京）中医药研究院有限公司 | Traditional Chinese medicine combination for treating amenorrhea and preparation method thereof |
| CN104984297A (en) * | 2015-07-24 | 2015-10-21 | 青岛蓝盛洋医药生物科技有限责任公司 | Application of pharmaceutical composition in preparation of drugs for treating amenorrhea |
| CN105288538A (en) * | 2015-09-30 | 2016-02-03 | 叶宗耀 | Application of medicine composition for preparing medicine for treating amenorrhea |
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| 田秦杰: "原发性闭经的病因", 《实用妇产科杂志》 * |
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