CN105193410A - EEG (electroencephalogram) signal amplifying system - Google Patents
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Abstract
The invention discloses an EEG (electroencephalogram) signal amplifying system. The EEG signal amplifying system comprises an EEG electrode cap, an EEG signal amplifying module and a parallel acquisition module, wherein the EEG electrode cap is arranged on the head surface and used for receiving an EEG of a cerebral cortex and outputting EEG analog signals; the EEG signal amplifying module performs differential amplification on the received EEG analog signals and comprises 36 unipolar signal amplifiers and 4 bipolar signal amplifiers; the parallel acquisition module comprises 40 AD (analog-digital) converters, any one of AD converter is only in lead connection with one unipolar signal amplifier or one bipolar signal amplifier, and the parallel acquisition module parallelly acquires 40 amplified EEG analog signals in real time and converts the signals into EEG digital signals. The EEG signal amplifying system can further improve the spatial resolution and can observe different functions of a brain region meticulously.
Description
Technical field
The present invention relates to a kind of EEG signals amplification system, more particularly, the present invention relates to and be a kind ofly applied to the schizoid amplification system possessing 40 channel parallel collections, amplification.
Background technology
Electroencephalogram (EEG) is cranial nerve cell bioelectrical activity in the overall reflection of cerebral cortex or scalp surface.Contain a large amount of physiology and disease information in EEG signals, in clinical medicine, EEG Processing not only can be some disease of brain and provides diagnosis basis, but also provides effective treatment means for some disease of brain.In engineer applied, people also attempt utilizing EEG signals to realize torsion free modules (BCI), utilizing people to the difference of the brain electricity of different sensations, motion or cognitive activities, controlling object by reaching certain to the effective extraction of EEG signals and classification.But because EEG signals does not possess ergodic nonstationary random signal, and its background noise is also very strong, and therefore the treatment and analysis of EEG signals is very attractive but is the research topic with suitable difficulty always.The invention provides efficient EEG signals and amplify scheme, the supervision and analysis technology be intended to for people's cerebral biological electricity provides new method.Schizophrenia is the not bright major psychosis of one group of cause of disease, many person between twenty and fifty slow or subacute onset, often show as the different syndrome of symptom clinically, relate to the inharmonious of many-sided obstacles such as sensory perception, thinking, emotion and behavior and ergasia.The general Clear consciousness of patient, intelligence is normal, but some patients there will be the infringement of cognitive function in lysis.The course of disease is generally delayed, and in recurrent exerbation, increases the weight of or worsens, and decline and mental handicap finally appear in some patients, but some patients can keep recovery from illness or the state that is almost recovered after treatment.
Summary of the invention
An object of the present invention is to solve at least the problems referred to above and defect, and the advantage will illustrated after providing.
A further object of the invention is to provide a kind of EEG signals amplification system, by arranging 40 a/d converter, can improve spatial resolution further, can careful observation brain district difference in functionality.
A further object of the invention is reservation single electrode goes to measure EEG signals while, and bipolar electrode measures level eye current potential, vertical eye current potential, myoelectric potential, these 4 signals of heart potential respectively, has good autgmentability.Last synchronous acquisition EEG signals and this few class signal, by analyzing the relatedness between this several unlike signal, carrying out more deep research and using.
A further object of the invention is by arranging magnetic coupling isolator between the first microprocessor and the second microprocessor of main control chip module, and Magnetic isolation is not only faster than light isolation speed, also has circuit design more succinct, the features such as integrated level is high, low-power consumption.
A further object of the invention arranges the stimulating module that can send the bionical electricity irritation of brain electricity by scalp, and to arrange in main control chip module and control stimulating module to carry out electricity irritation the 3rd microprocessor in feature region, simultaneously, 3rd microprocessor also records the conversion zone of the strongest EEG signals and the most weak EEG signals, user can according to the information obtained, obtain the relatedness of stimulated zone and conversion zone, and then judge whether this relatedness meets routine, reduce the time and difficulty of detecting disease.
In order to realize, according to these objects of the present invention and other advantage, providing a kind of EEG signals amplification system, comprise brain electrode cap, EEG signals amplification module and parallel acquisition module:
Described brain electrode cap is arranged on scalp, and it receives the brain electricity of cortex, and exports brain electric analoging signal;
The brain electric analoging signal differential amplification that described EEG signals amplification module will receive, it comprises 36 unipolar signal amplifiers and 4 bipolar signal amplifiers;
Described parallel acquisition module comprises 40 a/d converter, a/d converter described in any one with and only lead with a unipolar signal amplifier or bipolar signal amplifier, brain electric analoging signal real-time parallel after amplifying 40 tunnels gathers, and converts brain electricity digital signal to.
Preferably, described EEG signals amplification module also comprises the expansion electrode of 4 eye of reception level respectively electric potential signals, vertical eye electric potential signal, myoelectric potential signal and heart potential signal, and described 4 expansion electrodes are connected correspondingly with described 4 bipolar signal amplifiers.
Preferably, described EEG signals amplification system is also included in line impedence Sampling network, and it, by applying alternating current to described brain electrode cap, regulates the voltage of electrode-skin interface reaction, make impedance reach 5-80 milliohm.
Preferably, described EEG signals amplification system also comprises main control chip module, it comprises first microprocessor and the second microprocessor, wherein said first microprocessor is to parallel acquisition module transmitting control commands, judge whether to receive brain electricity digital signal from described parallel acquisition module according to resistance value, subsequently the 40 road brain electricity digital signals received are transferred to described second microprocessor through magnetic coupling isolator.
Preferably, described EEG signals amplification system also comprises USB2.0 data transmission module and Butterworth Filtering Processing module, described USB2.0 data transmission module synchronously receives the brain electricity digital signal that described second microprocessor exports, and to described Butterworth Filtering Processing module transfer, described Butterworth Filtering Processing module installation single order high pass, step low-pass two kinds of wave filter carry out filtering to gathered EEG signals data, complete the enlarging function of display EEG signals.
Preferably, described EEG signals amplification system also comprises the stimulating module be arranged on scalp, described stimulating module comprises and is evenly pasted on head electrode everywhere, be preferably on the acupuncture point of head, skull barrier stimulation brain is penetrated from the outer hurtless measure of cranium with imitative bio electricity, described stimulating module is connected with described main control chip module, and under the stimulation order that described main control chip module sends, described stimulating module carries out the bionical electricity irritation of brain electricity to scalp;
Wherein, described main control chip module also comprises the 3rd microprocessor, it carries out subregion to scalp, and described stimulating module is sent to the stimulation order of specific region, contrast the EEG signals that cerebral cortex sends after electricity irritation, record sends the conversion zone of the strongest EEG signals and the most weak EEG signals simultaneously.
Preferably, the input of described unipolar signal amplifier is to diode, and outfan is the operational amplifier of accurate skin peace level input current.
Preferably, the electric current of described bipolar signal amplifier is 1.3mA, and input imbalance is 50uV, and input bias current is 1nA, and CMRR is 100dB, and input noise is 0.28uV.
Preferably, the resolution of described a/d converter is 22bit, and dynamic range is 105dB, and non-linear is ± 0.003%, and the interface of described parallel acquisition module is spi bus interface.
Preferably, the bionical electricity irritation frequency of described brain electricity is 0.5Hz, and stimulating current intensity is 20-400 μ A.The present invention at least comprises following beneficial effect:
1, by arranging 40 a/d converter, spatial resolution can be improved further, can careful observation brain district difference in functionality.
2, by going at reservation single electrode to measure while EEG signals, bipolar electrode measures level eye current potential, vertical eye current potential, myoelectric potential, these 4 signals of heart potential respectively, has good autgmentability.Last synchronous acquisition EEG signals and this few class signal, by analyzing the relatedness between this several unlike signal, carrying out more deep research and using.
3, by arranging magnetic coupling isolator between the first microprocessor and the second microprocessor of main control chip module, Magnetic isolation is not only faster than light isolation speed, also has circuit design more succinct, the features such as integrated level is high, low-power consumption.
4, the stimulating module that can send the bionical electricity irritation of brain electricity is set by scalp, and to arrange in main control chip module and control stimulating module to carry out electricity irritation the 3rd microprocessor in feature region, simultaneously, 3rd microprocessor also records the conversion zone of the strongest EEG signals and the most weak EEG signals, user can according to the information obtained, obtain the relatedness of stimulated zone and conversion zone, and then judge whether this relatedness meets routine, reduce the time and difficulty of detecting disease.
Part is embodied by explanation below by other advantage of the present invention, target and feature, part also will by research and practice of the present invention by those skilled in the art is understood.
Accompanying drawing explanation
Fig. 1 is the system block diagram of embodiment 1 in the present invention.
Detailed description of the invention
Below in conjunction with accompanying drawing, the present invention is described in further detail, can implement according to this with reference to description word to make those skilled in the art.
Should be appreciated that used hereinly such as " to have ", other element one or more do not allotted in " comprising " and " comprising " term or the existence of its combination or interpolation.
A kind of EEG signals amplification system, comprises brain electrode cap, EEG signals amplification module and parallel acquisition module:
Described brain electrode cap is arranged on scalp, and it receives the brain electricity of cortex, and exports brain electric analoging signal;
The brain electric analoging signal differential amplification that described EEG signals amplification module will receive, it comprises 36 unipolar signal amplifiers and 4 bipolar signal amplifiers;
Described parallel acquisition module comprises 40 a/d converter, a/d converter described in any one with and only lead with a unipolar signal amplifier or bipolar signal amplifier, brain electric analoging signal real-time parallel after amplifying 40 tunnels gathers, and converts brain electricity digital signal to.
Described EEG signals amplification module also comprises the bipolar electrode of 4 eye of reception level respectively electric potential signals, vertical eye electric potential signal, myoelectric potential signal and heart potential signal, and described 4 bipolar electrodes are connected correspondingly with described 4 bipolar signal amplifiers.
Described EEG signals amplification system is also included in line impedence Sampling network, and it, by applying alternating current to described brain electrode cap, regulates the voltage of electrode-skin interface reaction, make impedance reach 5-80 milliohm.
Described EEG signals amplification system also comprises main control chip module, it comprises first microprocessor and the second microprocessor, wherein said first microprocessor is to parallel acquisition module transmitting control commands, judge whether to receive brain electricity digital signal from described parallel acquisition module according to resistance value, subsequently the 40 road brain electricity digital signals received are transferred to described second microprocessor through magnetic coupling isolator.
Described EEG signals amplification system also comprises USB2.0 data transmission module and Butterworth Filtering Processing module, described USB2.0 data transmission module synchronously receives the brain electricity digital signal that described second microprocessor exports, and to described Butterworth Filtering Processing module transfer, described Butterworth Filtering Processing module installation single order high pass, step low-pass two kinds of wave filter carry out filtering to gathered EEG signals data, complete the enlarging function of display EEG signals.
Described EEG signals amplification system also comprises the stimulating module be arranged on scalp, and described stimulating module is connected with described main control chip module, and under the stimulation order that described main control chip module sends, described stimulating module carries out the bionical electricity irritation of brain electricity to scalp;
Wherein, described main control chip module also comprises the 3rd microprocessor, it carries out subregion to scalp, and described stimulating module is sent to the stimulation order of specific region, contrast the EEG signals that cerebral cortex sends after electricity irritation, record sends the conversion zone of the strongest EEG signals and the most weak EEG signals simultaneously.
The input of described unipolar signal amplifier is to diode, and outfan is the operational amplifier of accurate skin peace level input current.
The electric current of described bipolar signal amplifier is 1.3mA, and input imbalance is 50uV, and input bias current is 1nA, and CMRR is 100dB, and input noise is 0.28uV.
The resolution of described a/d converter is 22bit, and dynamic range is 105dB, and non-linear is ± 0.003%.
The interface of described parallel acquisition module is spi bus interface.
The bionical electricity irritation frequency of described brain electricity is 0.5Hz, and stimulating current intensity is 20-400 μ A, and efficient output current amount is little, little to skin irritation, the acceptance level of user is high, and owing to being stimulate scalp, do not need to implant in brain, strengthen the satisfaction of user.
As shown in Figure 1,
Embodiment 1
A kind of EEG signals amplification system is by online impedance detection network, EEG signals amplification module, parallel acquisition module, buffer circuit, USB2.0 transport module, Triger circuit, digital Butterworth Filtering Processing display module, and totally 7 parts form.
Online impedance detection network
The size of electrode one skin contact impedance affects the quality of the physiological signals such as brain electricity, electrocardio, and excessive easy introducing 50Hz disturbs, and the amplitude of physiological signal also reduces.Online impedance detection is controlled built-in DA by port I2C by microprocessor in main control chip module 1, applies alternating current to electrode one skin contact, and the voltage signal of detecting electrode one skin contact reaction, calculates R=U/I.If impedance is excessive in implantation process, process will be adjusted, to reduce contact resistance.Online impedance detection network can realize the resistance value size that real-time show electrode cap contacts with scalp layer.
EEG signals amplification module
EEG signals is amplified, and reacting wider physiological signal can record, can the composition of reaction signal more realistically.EEG electro-physiological signals is generally picked up by metal, can produce polarization DC potential when contacting with meninges, generally at hundred more than mV, and analog digital conversion scope ± 2.5V, thus adopt low range to amplify.Low range is amplified, and the stability of amplification system is high, and reaction is fast, does not have AC amplification time constant.
EEG signals amplification module of the present invention comprises unipolar signal amplifier and bipolarity magnifying electrode.Overall channel number is 40, and wherein unipolarity port number is 36, and ambipolar port number is 4.Unipolarity amplifies employing homophase structure for amplifying, and this structure has high input impedance.Structure is simple, is easy to parameter consistency, is easy to carry out software difference, improves common mode rejection ratio.Input takes diode, can effectively to antistatic, and protect accurate skin to pacify level input current amplifying device and do not damaged by electrostatic, amplification can reach 19 times.Bipolarity amplifies the instrument amplifier adopting classics, Circuit Classical, A/D chip, is easy to realize.The feature of A/D chip: low-power consumption: 1.3mA, input imbalance: 50uV, input bias current: 1nA, CMRR:100dB.Input noise: 0.28uV, amplification can reach 10 times.
Impedance detection, by the 30Hz sinusoidal signal of 10M Ω, is loaded between electrode and ground, after collection, through the IIR band filter of 28 to 8Hz, detects its amplitude Vx.By the contact impedance between the tested passage of formulae discovery and reference.
Parallel acquisition module
Parallel acquisition module is the EEG signals in order to record scalp, is made up of 40 a/d converter, can carry out Synchronization Control, collection, realize the synchronicity between event channel to 40 road signals, can realize adding of signal to cut algorithm.Its feature is comprise 4 independently analog digital conversion inside each module.Spi bus interface is also easy to daisy chain structure design cascade.Designed by daisy chain structure, realize gathering the data of 40 passages.Acquisition rate, by software control, can reach 1000Hz.
After data syn-chronization EOC, by CASCIN, the SDATA starting sheet #1 exports data, and the SDATA of sheet #2 forbids exporting, and when sheet #1 data end of output, its CASCOUT notifies sheet #2, allows No. 2 outputs.Daisy chain structure that Here it is designs, and so repeatedly carries out cascade, meets Multi-Channel Parallel Acquisition demand.
Buffer circuit
The function of buffer circuit is restraint speckle interference.In order to reach national safety standard, buffer circuit adopts high speed magnetic isolation technology, faster than light isolation speed, and reach 10MHz, isolation voltage is up to 5000V.It is more succinct that Magnetic isolation also has circuit design, the features such as integrated level is high, low-power consumption (being only the 1/10-1/6 of optocoupler).
USB2.0 data are transmitted
Data transmission adopts USB2.0 agreement.Traffic rate is up to 480MHz, and CY7C68013 selected by device.By usb2.0 transmission means, the EEG signals collected is transferred to computer.
Triger circuit
Triger circuit is stimulation circuit again, and function is the code sending stimulus object.Stimulate code and reaction code receiving circuit to comprise serial ports, parallel port form, reaction button receiving circuit is 4bit mode.Wherein serial ports receives baud rate is 115.2kbps, 10bit, start bit, position of rest agreement.
The display of numeral Butterworth Filtering Processing
Filtering Processing is to remove interference.Modern digital filtering technique is ripe, no matter is real-time or afterwards, can extract the signal that institute needs easily.Design basis ground motion low order iir filter, uses software engineering, realizes multiband, various filters, the multichannel physiological single processing ability of acceleration.
1. impedance detection is by the 30Hz sinusoidal signal of 10M Ω, is loaded between electrode and ground, after collection, through the IIR band filter of 28 to 8Hz, detects its amplitude Vx.By the contact impedance between the tested passage of formulae discovery and reference.EEG signals amplification module of the present invention comprises unipolarity and amplifies and bipolarity amplification.Overall channel number is 40, and wherein unipolarity port number is 36, and ambipolar port number is 4.One pole amplification can reach 19 times.Bipolar amplification can reach 10 times.
2. parallel acquisition module is made up of 40 AD, can carry out Synchronization Control, collection, realize the synchronicity between event channel to 40 road signals, can realize adding of signal to cut algorithm.
3.Triger circuit (stimulation circuit) stimulates code and reaction code receiving circuit to comprise serial ports, parallel port form, and reaction button receiving circuit is 4bit mode.
4. buffer circuit adopts high speed magnetic isolation technology, and reach 10MHz, isolation voltage is up to 5000V.
5. transport module adopts high speed USB 2.0 to transmit.
6. adopt digital Butterworth Filtering Processing, design basis ground motion low order iir filter, use software engineering to realize multiband, various filters, the multichannel physiological single processing ability of acceleration.
The advantage of unipolarity and bipolarity combination
While reservation single electrode goes to measure EEG signals, bipolar electrode measures level eye current potential, vertical eye current potential, myoelectric potential, these 4 signals of heart potential respectively, has good autgmentability.Last synchronous acquisition EEG signals and this few class signal, by analyzing the relatedness between this several unlike signal, carrying out more deep research and using.The effect of eye current potential is for eliminating artefact nictation (the eye current potential that nictation produces in process).Artefact was common noise in eeg signal acquisition process, produced have a strong impact on the extraction of effective EEG signals nictation.In order to reduce the interference of artefact nictation, ordinary circumstance tester can require that acceptance test personnel control oneself eye motion for a long time, this not only can cause ophthalmic uncomfortable, simultaneously suffering from the child of hyperkinetic syndrome, the patient of mental sickness is unmanageable with it.A kind of mode is also had to be that algorithm goes to eliminate interfering signal, decomposed the signal gathered by algorithm, contrast the difference between EEG signals and electro-ocular signal simultaneously, be removed, shortcoming is many, the consuming time length of algorithm requirement data volume, has higher requirement to the professional ability of user simultaneously.Bipolar signal amplifier of the present invention can independently use, and is attached to eyelid upper and lower, after obtaining a current potential absolute value, deducts an electric potential signal and draw accurate signal in primary signal.Advantage be without the need to acceptance test personnel control nictation, test process is simple, consuming time short.
Other physiologic information of bipolar signal amplifier essential record, comprises ECG, EOG (level, vertical), EMG etc.Physiological signal is weak signal, and common mode is relatively more serious, in order to obtain good information, all adopts Differential Input pattern.
40 meanings of leading and selectivity use feasibility.
40 lead resolution, mainly can improve spatial resolution further, can careful observation brain district difference in functionality.Develop into now 256 to lead or 512 to lead.
40 lead and can screen, can independent assortment, by an addition and subtraction that leads, and the different characteristic of analytic signal.Instrument is all kinds of computational science software, as matlab etc.
Industrial applicibility of the present invention
1, by arranging 40 a/d converter, spatial resolution can be improved further, can careful observation brain district difference in functionality.
2, while reservation single electrode goes to measure EEG signals, bipolar electrode measures level eye current potential, vertical eye current potential, myoelectric potential, these 4 signals of heart potential respectively, has good autgmentability.Last synchronous acquisition EEG signals and this few class signal, by analyzing the relatedness between this several unlike signal, carrying out more deep research and using.
3, by arranging magnetic coupling isolator between the first microprocessor and the second microprocessor of main control chip module, Magnetic isolation is not only faster than light isolation speed, also has circuit design more succinct, the features such as integrated level is high, low-power consumption.
4, the stimulating module that can send the bionical electricity irritation of brain electricity is set by scalp, and to arrange in main control chip module and control stimulating module to carry out electricity irritation the 3rd microprocessor in feature region, simultaneously, 3rd microprocessor also records the conversion zone of the strongest EEG signals and the most weak EEG signals, user can according to the information obtained, obtain the relatedness of stimulated zone and conversion zone, and then judge whether this relatedness meets routine, reduce the time and difficulty of detecting disease.
Although embodiment of the present invention are open as above, it is not restricted to listed in description and embodiment utilization.It can be applied to various applicable the field of the invention completely.For those skilled in the art, can easily realize other amendment.Therefore do not deviating under the general concept that claim and equivalency range limit, the present invention is not limited to specific details and illustrates here and the legend described.
Claims (10)
1. an EEG signals amplification system, comprises brain electrode cap, EEG signals amplification module and parallel acquisition module, it is characterized in that:
Described brain electrode cap is arranged on scalp, and it receives the brain electricity of cortex, and exports brain electric analoging signal;
The brain electric analoging signal differential amplification that described EEG signals amplification module will receive, it comprises 36 unipolar signal amplifiers and 4 bipolar signal amplifiers;
Described parallel acquisition module comprises 40 a/d converter, a/d converter described in any one with and only lead with a unipolar signal amplifier or bipolar signal amplifier, brain electric analoging signal real-time parallel after amplifying is gathered, and converts brain electricity digital signal to.
2. EEG signals amplification system as claimed in claim 1, it is characterized in that, also comprise the bipolar electrode of 4 eye of reception level respectively electric potential signals, vertical eye electric potential signal, myoelectric potential signal and heart potential signal, described 4 bipolar electrodes and described 4 bipolar signal amplifiers lead correspondingly.
3. EEG signals amplification system as claimed in claim 1, is characterized in that, be also included in line impedence Sampling network, and it, by applying alternating current to described brain electrode cap, regulates the voltage of electrode-skin interface reaction, make impedance reach 5-80 milliohm.
4. EEG signals amplification system as claimed in claim 2, it is characterized in that, also comprise main control chip module, it comprises first microprocessor and the second microprocessor, wherein said first microprocessor is to parallel acquisition module transmitting control commands, judge whether to receive brain electricity digital signal from described parallel acquisition module according to resistance value, subsequently the 40 road brain electricity digital signals received are transferred to described second microprocessor through magnetic coupling isolator.
5. EEG signals amplification system as claimed in claim 3, it is characterized in that, also comprise USB2.0 data transmission module and Butterworth Filtering Processing module, described USB2.0 data transmission module synchronously receives the brain electricity digital signal that described second microprocessor exports, and to described Butterworth Filtering Processing module transfer, described Butterworth Filtering Processing module installation single order high pass, step low-pass two kinds of wave filter carry out filtering to gathered EEG signals data, complete the enlarging function of display EEG signals.
6. EEG signals amplification system as claimed in claim 3, it is characterized in that, also comprise the stimulating module be arranged on scalp, described stimulating module is connected with described main control chip module, under the stimulation order that described main control chip module sends, described stimulating module carries out the bionical electricity irritation of brain electricity to scalp;
Wherein, described main control chip module also comprises the 3rd microprocessor, it carries out subregion to scalp, and described stimulating module is sent to the stimulation order of specific region, contrast the EEG signals that cerebral cortex sends after electricity irritation, record sends the conversion zone of the strongest EEG signals and the most weak EEG signals simultaneously.
7. EEG signals amplification system as claimed in claim 1, it is characterized in that, the input of described unipolar signal amplifier is to diode, and outfan is the operational amplifier of accurate skin peace level input current.
8. EEG signals amplification system as claimed in claim 1, it is characterized in that, the electric current of described bipolar signal amplifier is 1.3mA, and input imbalance is 50uV, and input bias current is 1nA, and CMRR is 100dB, and input noise is 0.28uV.
9. EEG signals amplification system as claimed in claim 1, it is characterized in that, the resolution of described a/d converter is 22bit, and dynamic range is 105dB, and non-linear is ± 0.003%, and the interface of described parallel acquisition module is spi bus interface.
10. EEG signals amplification system as claimed in claim 5, is characterized in that, the bionical electricity irritation frequency of described brain electricity is 0.5Hz, and stimulating current intensity is 20-400 μ A.
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| CN106859642A (en) * | 2017-02-22 | 2017-06-20 | 武汉智普天创科技有限公司 | Eeg signal acquisition processing control apparatus |
| CN112006684A (en) * | 2020-09-10 | 2020-12-01 | 南京邮电大学 | Hidden information flow research method based on virtual human body information network |
| CN115105099A (en) * | 2022-07-18 | 2022-09-27 | 华南理工大学 | Electroencephalogram amplification system capable of outputting iteration enhancement signals |
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