CN105194003A - Disinfectant used for cleaning up wounds - Google Patents
Disinfectant used for cleaning up wounds Download PDFInfo
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- CN105194003A CN105194003A CN201510656653.XA CN201510656653A CN105194003A CN 105194003 A CN105194003 A CN 105194003A CN 201510656653 A CN201510656653 A CN 201510656653A CN 105194003 A CN105194003 A CN 105194003A
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Abstract
The invention discloses a disinfectant used for cleaning up wounds. The disinfectant is prepared from the following main raw materials in parts by weight: 1-3 parts of benzalkonium chloride, 3-7 parts of herb of Japanese thistle, 2-6 parts of baikal skullcap root, 3-7 parts of platycladus orientalis carbonisatus, 1-5 parts of wild chrysanthemum, 5-10 parts of cape jasmine fruit, 6-12 parts of honeysuckle flower, 200-400 parts of water for injection and 3-5 parts of hydrogen peroxide. The disinfectant is low in production cost, simple in preparation process and easy in realization of process conditions and has good product stability.
Description
divisional application, original applying number 2014104116007, applying date 2014.08.20, title is for the disinfectant solution that cleans a wound and preparation method.
Technical field
The present invention relates to traditional Chinese medicine field, particularly relating to a kind of disinfectant solution for cleaning a wound and preparation method.
Background technology
Operation technique or wound, particularly hemorrhage, oozing of blood, be sometimes difficult to control, not only can increase blood loss but also can increase operating difficulty, even threat to life.Beijing Hospital's surgical specialist Cao Jin tongued bell is thought, any surgical procedures almost relates to hemorrhage with hemostasis bar none, and good hemostasis is the operation safety prerequisite of carrying out and guarantee.In operation, the choose reasonable of Hemostasis can control that wound surface is hemorrhage, oozing of blood, guarantee visual area is clear, improve procedure efficiency, shorten operating time, thus minimizing is lost blood and is transfused blood, be conducive to avoiding the generation with postoperative related complication in art, accelerate patient's post-operative recovery, and then alleviate misery and the medical expense of patient.Annual hemorrhagic disease number is more than 9,000,000 people, and be mainly distributed in surgical departments and part internal medicine section office, in multiple Hemostasis, hemorrhage is widely used.In recent decades, the haemostatic medicaments such as hemocoagulase, because it is not by the restriction of the aspect such as operative site, Surgical Operation, generally adopt in various operation.Along with the continuous renewal of hemostasis theory, new haemostatic medicament is also constantly released.
Wound, refers to the outer damage that health or object cause due to the erosion etc. of the strike of external object, collision or chemical substance.Refer to the emotions such as the indignant worry because producing by external irritant.To record in " numerous Lu Xuntianzhi in spring and autumn road " as Han dynasty Dong Zhong relaxes: with happy person, outside raw, Thailand also; Spirit person, fills also within raw; If outer Thailand not in fill, much less wound? angryly sympathize melancholy hatred person, the wound of life also; With say the person of encouraging people to do good, life support also.Wound, language goes out " Plain Questions distracting patient’s attention to change the flow of QI-blood opinion ".1. one of injury symptoms classification.Refer generally to pounce on the damage of skin caused by tumbling down, muscle, muscles and bones.2., for internal injury caused by excess of seven emotions, refer to that six climate exopathogens exopathogen hindered, as cold, typhoid fever, affection of dampness, Sunstroke etc.Wound comprises bullet, Jin Ren, traumatic injury, injury by overexertion, burn and scald, cold injury and insect-animal injury etc.The wounds such as bullet, Jin Ren, traumatic injury, injury by overexertion, can cause integumentary musculature swelling and pain due to blood stasis, hemorrhage, or injury of tendon and muscle fracture, dislocation.Heavy then damage internal organs, or Massive Bleeding, the serious change such as stupor, tic, YANG-depletion collapse can be caused.How burn and scald, caused by high temperature article, boiling water or deep fat or burn and scald etc.The lighter damages skin, red in injury, swollen, hot, bitterly, xerosis cutis or get blister, severe pain; Severe burn and scald then muscle injury, muscles and bones can make analgesis, and wound surface is as leather sample, or wax is white, sallow or carbonization; Serious burn and scald, then it is excessive to hinder face, and apart from outside local symptom, Chang Yin has an intense pain, fire-toxin inside fire attack, body fluid evaporation or ooze out, and can occur that dysphoria, heating, xerostomia are thirsty, oliguria etc., even dead.Cold injury, refers to that human body is damaged by the general caused by low temperature invasion and attack or locality.General cold injury, because of cold being a kind of YIN pathogen, easy impairment of YANG gas, YIN-cold crosses Sheng, and yang-energy is impaired, and lose in warm and promotion blood, then shiver with cold, body temperature declines gradually, pale complexion, bluish lip, and fingernail is livid purple, stolidity, spiritlessness and weakness, or lethargy, hypopnea, and slow pulse is thin.If do not given treatment to, easily lethally to die.Part frozen, mostly occurs in hands, foot, auricle, nose and face position.Fall ill from the beginning of, position of enduring cold is because of cold main spasm, and passages through which vital energy circulates contraction is anxious, and coagulation of QI-blood is smooth, and impact is endured cold the warm and nutrition of local, and cause local skin pale, cold fiber crops, the then swelling that continues is livid purple, itches bitterly scorching hot, or occurs the blister etc. that differs in size, normal easy infection after diabrosis.Insect-animal injury, comprises poisonous snake, the beast of prey, mad dog bites, or scorpion, bee sting wound etc.Swelling and ache, appear in light then local damage, hemorrhage etc.; Heavy then damage internal organs, or Massive Bleeding and dead.Then there is systemic toxicity profiles symptom in venom, as given treatment to not in time, often causes being poisoned to death.Mad dog is bitten, from the beginning of rarely seen local pain, hemorrhage, after wound healing, through one period of incubation period, then can occur agitation, greatly alarmed, gnathospasma, tic, hydrophobia, the probably disease such as wind.
Well-known: the wound of wound and operation, if dealt with improperly, inflammation and the pain of local can be caused, bring many miseries to patient.
Authorization Notice No. CN102813751B(Authorization Notice No. CN102813751B) Chinese patent literature disclose a kind of wound treatment agent, it is characterized in that, be decocted with water by the raw material of Chinese medicine of following weight parts, filter, concentrated water extract; The weight portion of described raw material of Chinese medicine is: Folium Callicarpae Formosanae 30 parts, Radix Sanguisorbae dry product 15 parts, Lignum Dalbergiae Odoriferae 6 parts, Herba Corydalis Bungeanae dry product 12 parts, Myrrha 3 parts, Radix Angelicae Sinensis 6 parts, Herba Salviae Chinensis 12 parts, Radix Rehmanniae Preparata 15 parts, Radix Arnebiae (Radix Lithospermi) 12 parts, 20 parts, Radix Glycyrrhizae; The weight of described water extract is that 1.5-2.0 is doubly to the weight of medical material dry product.Application publication number CN102462732A(application publication number CN102462732A) Chinese patent literature disclose a kind of Wound disinfectant, it is characterized in that: the component comprising following parts by weight: oils and fats perforatum extract 5-18 part, Herba Clinopodii Polycephali 10-25 part, non-ionic surface active agent 3-8 part, trichloro hydroxyl diphenyl ether 6-15 part, medical alcohol 25-50 part, deionized water 80-120 part.
In a word, Chinese medicine achieves certain effect in development in the disinfectant solution that cleans a wound, but also there is following problem: existing disinfectant solution, and therapeutic effect is not good enough, needs to be improved further.
Summary of the invention
For the deficiencies in the prior art, an object of the present invention is that providing a kind of prepares the disinfectant solution for cleaning a wound simple, easy to use, has effect of quick-acting haemostatic powder, bactericidal antiphlogistic, to the treatments for bleeding Be very effective that wound causes.
Another object of the present invention is to provide the preparation method of above-mentioned wound gelfoam.
Technical scheme of the present invention is:
For the disinfectant solution cleaned a wound, take off the primary raw material stating weight proportion and be prepared from: benzalkonium chloride 1-3 part, Radix Cirsii Japonici 3-7 part, Radix Scutellariae 2-6 part, Cacumen Platycladi preparata 3-7 part, Flos Chrysanthemi Indici 1-5 part, Fructus Gardeniae 5-10 part, and Flos Lonicerae 6-12 part (preferred, Flos Lonicerae 7-10 part; Be more preferably, Flos Lonicerae 8.5 parts), water for injection 200-400 part, hydrogen peroxide 3-5 part.
For the disinfectant solution cleaned a wound, preferred scheme is: take off the primary raw material stating weight proportion and be prepared from: benzalkonium chloride 1.5-2.5 part, Radix Cirsii Japonici 4-6 part, Radix Scutellariae 3-5 part, Cacumen Platycladi preparata 4-6 part, Flos Chrysanthemi Indici 2-4 part, Fructus Gardeniae 6-9 part, Flos Lonicerae 8-10 part, water for injection 250-350 part, hydrogen peroxide 3.5-4.5 part.
For the disinfectant solution cleaned a wound, better preferred scheme is: take off the primary raw material stating weight proportion and be prepared from: benzalkonium chloride 2 parts, Radix Cirsii Japonici 5 parts, Radix Scutellariae 4 parts, Cacumen Platycladi preparata 5 parts, Flos Chrysanthemi Indici 3 parts, Fructus Gardeniae 8 parts, Flos Lonicerae 9 parts, water for injection 300 parts, hydrogen peroxide 4 parts.
According to the preparation method of arbitrary described disinfectant solution for cleaning a wound above, preferred scheme is: step is as follows:
(1) Flos Chrysanthemi Indici is placed in marmite, is dipped to the complete variable color of water with water for injection, filter, filtrate is for subsequent use, is exposed to the sun, the Flos Chrysanthemi Indici dried and Radix Cirsii Japonici, Radix Scutellariae, Cacumen Platycladi preparata, Fructus Gardeniae and Flos Lonicerae ethanol is mixed thoroughly under the Flos Chrysanthemi Indici after immersion is placed in daylight, stewing 10-20 hour, takes out stand-by;
(2) joined in step (1) gained filtrate by step (1) gained crude drug, intense fire is fried open, and turns 20-40 minute at a simmer, filters, and filtrate cooling is for subsequent use;
(3) step (3) gained filtrate and benzalkonium chloride are added in Agitation Tank, leave standstill after 1-3 hour, stir at 40-60 DEG C after 0.5-1.5 hour and obtain buffer solution, then buffer solution temperature is down to-5-0 DEG C;
(4) hydrogen peroxide is joined in step (3) gained buffer solution, continue to stir 0.5-1.5 hour to obtain disinfectant solution;
(5) by step (4) gained disinfectant solution by filtering with microporous membrane, subpackage and get final product.
Foregoing preparation method, it is characterized in that: step (1) is exposed to the sun 4-6 days (preferably under the Flos Chrysanthemi Indici after immersion is placed in daylight, be exposed to the sun under Flos Chrysanthemi Indici after immersion is placed in daylight 4.5-5.5 days, is more preferably, and is exposed to the sun 5 days under the Flos Chrysanthemi Indici after immersion is placed in daylight).
Foregoing preparation method, is characterized in that: step (1) boils in a covered pot over a slow fire 13-18 hour, takes out stand-by (preferred stewing 15 hours, take out stand-by).
Foregoing preparation method, is characterized in that: step (3) stirs after 0.6-0.8 hour and obtains buffer solution (preferably stir at 50 DEG C after 0.7 hour and obtain buffer solution) at 45-55 DEG C.
Foregoing preparation method, is characterized in that: buffer solution temperature is down to-4 to-2 DEG C (preferably buffer solution temperature being down to-3 DEG C) by step (3).
Foregoing preparation method, is characterized in that: disinfectant solution (preferred continuation stirring obtains disinfectant solution in 1 hour) is stirred 0.8-1.3 hour to obtain in step (4) step (4) continuation.
Foregoing preparation method, is characterized in that: the aperture of step (5) described microporous filter membrane is 0.10-0.45 μm (preferred aperture is 0.15-0.30, and being more preferably aperture is 0.22 μm).
Using method: after traumatic hemorrhage, epistaxis, gets one piece for the disinfectant solution that cleans a wound directly by being pressed in bleeding part.
The pharmacological effect of each crude drug is respectively:
Benzalkonium chloride: benzalkonium chloride is a kind of cationic surfactant, belong to non oxidizing bactericide, there is wide spectrum, efficiently sterilization algae removal ability, effectively can control bacterium algae propagation and foundry loam growth in water, and there is good sludge stripping effect and certain dispersion, osmosis, have simultaneously certain to deoil, deodorizing capability and corrosion inhibition.Benzalkonium chloride is made into the aqueous solution of 1:1000, for operation consent medical worker both hands soaking disinfection.The cleaning and disinfecting of traumatic infection can with the Benza of 0.01% concentration.
Radix Cirsii Japonici: nature and flavor: sweet, bitter, cold.Gui Jing: GUIXIN, Liver Channel.Effect: cooling blood for hemostasis, removing blood stasis to reduce swelling.Cure mainly: for epistaxis.Spit blood.Hematuria, has blood in stool, metrostaxis, traumatic hemorrhage, carbuncle sore tumefacting virus.
Radix Scutellariae: nature and flavor: bitter, cold.Gui Jing: return lung, gallbladder, spleen, large intestine, small intestine meridian.Effect: heat clearing and damp drying, rushes down people's removing toxic substances, hemostasis, antiabortive.Cure mainly: for hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, cough due to lung-heat, high hot excessive thirst, heat in blood tells nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.
Cacumen Platycladi preparata: be the Preparation process product of Cacumen Platycladi is bitter, puckery, cold.Return lung, liver, spleen channel.Astringing to arrest bleeding.Hemorrhage for deficient cold type, spitting of blood, spits blood, has blood in stool, metrostaxis.
Flos Chrysanthemi Indici: nature and flavor: bitter, pungent, is slightly cold.Gui Jing: return liver, heart channel.Effect: heat-clearing and toxic substances removing.Cure mainly: for furuncle carbuncle, conjunctival congestion and swelling pain.Have a headache dizzy.
Fructus Gardeniae: nature and flavor: bitter, cold.Gui Jing: GUIXIN, lung, tri-jiao channel.Effect: pathogenic fire purging relieving restlessness, clearing away heat and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body.Cure mainly: vexed for calentura, yellow cellulitis dark coloured urine, blood strangury and dry pain, heat in blood tells nosebleed, conjunctival congestion and swelling pain, pathogenic fire,toxin and furuncles; External treatment bruise pain.
Flos Lonicerae: Flos Lonicerae is cold in nature, sweet in the mouth, enters lung, the heart, stomach warp, has heat-clearing and toxic substances removing, antiinflammatory, tonify deficiency treat effect of wind, cures mainly disease under distension, epidemic febrile disease heating, the diseases such as pyretic toxicity carbuncle and ulcer and tumor.The diseases such as it is dizzy for giddy, xerostomia is done yearningly, hyperhidrosis is unhappy, enteritis, bacillary dysentery, measles, pneumonia, encephalitis b, epidemic encephalitis, acute mastitis, septicemia, appendicitis, skin infection, carbuncle furuncle, erysipelas, parotitis, suppurative tonsillitis all have certain curative effect.
Water for injection: the water that water for injection specifies under referring to meet Chinese Pharmacopoeia water for injection item.Water for injection be distilled water or deionization through distilling the water of gained, therefore also known as double distilled water.The preparation of water for injection, storage and distribution should be able to prevent growing of microorganism and pollute.Basin and conveyance conduit material therefor should be nontoxic, corrosion-resistant.The design and installation of pipeline should avoid dead angle, blind pipe.Basin and pipeline will specify cleaning, sterilising cycle.The blow vent of injection water storage tank should install the hydrophobicity germ tight filter of the fiber that do not come off.The storage of water for injection can adopt more than 80 DEG C insulations, more than 70 DEG C soak cycles or less than 4 DEG C are deposited.Pharmacological action: solvent.
Hydrogen peroxide: hydrogen peroxide chemistry formula is H2O2, is commonly called as hydrogen peroxide.Outward appearance is colourless transparent liquid, is a kind of strong oxidizer, and its aqueous solution is applicable to wound disinfection and environment, food sterilization.Daily sterilization be medical hydrogen peroxide, medical hydrogen peroxide can kill pathogenic entero becteria, pyococcus, and pathogenic yeast bacterium, is generally used for surface disinfection.Hydrogen peroxide has Oxidation, but medical hydrogen peroxide concentration is equal to or less than 3%, wipes wound face, has burning sensation, surface is oxidized to white and emits bubble, just passable once by clean water, crosses and just recovers the original colour of skin in 3-5 minutes.
The present invention is simple for the disinfectant solution preparation method cleaned a wound, and selected principle is cheap, and very remarkable to the effect that cleans a wound, can good bactericidal haemostatic.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.
embodiment 1for the disinfectant solution cleaned a wound, take off the primary raw material stating weight proportion and be prepared from: benzalkonium chloride 1 gram, Radix Cirsii Japonici 3 grams, Radix Scutellariae 2 grams, Cacumen Platycladi preparata 3 grams, Flos Chrysanthemi Indici 1 gram, Fructus Gardeniae 5 grams, Flos Lonicerae 6 grams, water for injection 200 grams, hydrogen peroxide 3 grams.
The preparation method of the above-mentioned disinfectant solution for cleaning a wound, step is as follows:
(1) Flos Chrysanthemi Indici is placed in marmite, is dipped to the complete variable color of water with water for injection, filter, filtrate is for subsequent use, is exposed to the sun 4 days, the Flos Chrysanthemi Indici dried and Radix Cirsii Japonici, Radix Scutellariae, Cacumen Platycladi preparata, Fructus Gardeniae and Flos Lonicerae ethanol is mixed thoroughly under the Flos Chrysanthemi Indici after immersion is placed in daylight, stewing 10 hours, take out stand-by;
(2) joined in step (1) gained filtrate by step (1) gained crude drug, intense fire is fried open, and turns 20 minutes at a simmer, filters, and filtrate cooling is for subsequent use;
(3) step (3) gained filtrate and benzalkonium chloride are added in Agitation Tank, leave standstill after 1 hour, stir at 40 DEG C after 0.5 hour and obtain buffer solution, then buffer solution temperature is down to-5 DEG C;
(4) hydrogen peroxide is joined in step (3) gained buffer solution, continue stirring and obtain disinfectant solution in 0.5 hour;
(5) by step (4) gained disinfectant solution by filtering with microporous membrane, the aperture of microporous filter membrane is 0.10 μm, subpackage and get final product.
embodiment 2for the disinfectant solution cleaned a wound, take off the primary raw material stating weight proportion and be prepared from: benzalkonium chloride 3 grams, Radix Cirsii Japonici 7 grams, Radix Scutellariae 6 grams, Cacumen Platycladi preparata 7 grams, Flos Chrysanthemi Indici 5 grams, Fructus Gardeniae 10 grams, Flos Lonicerae 12 grams, water for injection 400 grams, hydrogen peroxide 5 grams.
The preparation method of the above-mentioned disinfectant solution for cleaning a wound, step is as follows:
(1) Flos Chrysanthemi Indici is placed in marmite, is dipped to the complete variable color of water with water for injection, filter, filtrate is for subsequent use, is exposed to the sun 6 days, the Flos Chrysanthemi Indici dried and Radix Cirsii Japonici, Radix Scutellariae, Cacumen Platycladi preparata, Fructus Gardeniae and Flos Lonicerae ethanol is mixed thoroughly under the Flos Chrysanthemi Indici after immersion is placed in daylight, stewing 20 hours, take out stand-by;
(2) joined in step (1) gained filtrate by step (1) gained crude drug, intense fire is fried open, and turns 40 minutes at a simmer, filters, and filtrate cooling is for subsequent use;
(3) step (3) gained filtrate and benzalkonium chloride are added in Agitation Tank, leave standstill after 3 hours, stir at 60 DEG C after 1.5 hours and obtain buffer solution, then buffer solution temperature is down to 0 DEG C;
(4) hydrogen peroxide is joined in step (3) gained buffer solution, continue stirring and obtain disinfectant solution in 1.5 hours;
(5) by step (4) gained disinfectant solution by filtering with microporous membrane, the aperture of microporous filter membrane is 0.45 μm, subpackage and get final product.
model case one: Zhu XX, female, 27 years old.Patient is before 1 hour, go on a visit to the seaside together with colleague, accidentally by the little shell incised wound right crus of diaphragm thumb on seashore, in water, do not have pain at once, after disembarkation, sensation right crus of diaphragm thumb pain, also has many blood to bleed, limitation of activity, oneself stops blooding with the alcohol wipe carried with, subsides adhesive bandage, and effect is all not obvious, and kind colleague allows it use the disinfectant solution for cleaning a wound oneself carried with.
Using the disinfectant solution of the embodiment of the present invention 2 gained for cleaning a wound, by gelfoam directly by being pressed in export department position, pressing after 1 minute, hemorrhage obvious minimizing; Press 3 minutes, wound hemostasis, bleeds and stops completely.
embodiment 3for the disinfectant solution cleaned a wound, take off the primary raw material stating weight proportion and be prepared from: benzalkonium chloride 1.5 grams, Radix Cirsii Japonici 4 grams, Radix Scutellariae 3 grams, Cacumen Platycladi preparata 4 grams, Flos Chrysanthemi Indici 2 grams, Fructus Gardeniae 6 grams, Flos Lonicerae 8 grams, water for injection 250 grams, hydrogen peroxide 3.5 grams.
The preparation method of the above-mentioned disinfectant solution for cleaning a wound, step is as follows:
(1) Flos Chrysanthemi Indici is placed in marmite, is dipped to the complete variable color of water with water for injection, filter, filtrate is for subsequent use, is exposed to the sun 4.5 days, the Flos Chrysanthemi Indici dried and Radix Cirsii Japonici, Radix Scutellariae, Cacumen Platycladi preparata, Fructus Gardeniae and Flos Lonicerae ethanol is mixed thoroughly under the Flos Chrysanthemi Indici after immersion is placed in daylight, stewing 13 hours, take out stand-by;
(2) joined in step (1) gained filtrate by step (1) gained crude drug, intense fire is fried open, and turns 25 minutes at a simmer, filters, and filtrate cooling is for subsequent use;
(3) step (3) gained filtrate and benzalkonium chloride are added in Agitation Tank, leave standstill after 1.3 hours, stir at 45 DEG C after 0.8 hour and obtain buffer solution, then buffer solution temperature is down to-4 DEG C;
(4) hydrogen peroxide is joined in step (3) gained buffer solution, continue stirring and obtain disinfectant solution in 0.8 hour;
(5) by step (4) gained disinfectant solution by filtering with microporous membrane, the aperture of microporous filter membrane is 0.15 μm, subpackage and get final product.
model case two: Lee XX, man, 13 years old, the student in certain middle school, from June, the always epistaxis of unknown cause, each is all wake up morning, within one week, sometimes can occur 2 times, remove examination in hospital, it is abnormal what does not find yet, but or epistaxis, neighbours see that its symptom tells its father and mother, say that the present invention is for the disinfectant solution effect that cleans a wound very good, goes home to use to son so patient has just bought some.
Use the disinfectant solution of the present embodiment 3 gained for cleaning a wound, get gelfoam directly by being pressed on nostril, after 2 minutes, hemorrhage obvious minimizing, after 4 minutes, blood flow stops.
embodiment 4for the disinfectant solution cleaned a wound, take off the primary raw material stating weight proportion and be prepared from: benzalkonium chloride 2.5 grams, Radix Cirsii Japonici 6 grams, Radix Scutellariae 5 grams, Cacumen Platycladi preparata 6 grams, Flos Chrysanthemi Indici 4 grams, Fructus Gardeniae 9 grams, Flos Lonicerae 10 grams, water for injection 350 grams, hydrogen peroxide 4.5 grams.
The preparation method of the above-mentioned disinfectant solution for cleaning a wound, step is as follows:
(1) Flos Chrysanthemi Indici is placed in marmite, is dipped to the complete variable color of water with water for injection, filter, filtrate is for subsequent use, is exposed to the sun 5.5 days, the Flos Chrysanthemi Indici dried and Radix Cirsii Japonici, Radix Scutellariae, Cacumen Platycladi preparata, Fructus Gardeniae and Flos Lonicerae ethanol is mixed thoroughly under the Flos Chrysanthemi Indici after immersion is placed in daylight, stewing 18 hours, take out stand-by;
(2) joined in step (1) gained filtrate by step (1) gained crude drug, intense fire is fried open, and turns 35 minutes at a simmer, filters, and filtrate cooling is for subsequent use;
(3) step (3) gained filtrate and benzalkonium chloride are added in Agitation Tank, leave standstill after 2.5 hours, stir at 55 DEG C after 1.3 hours and obtain buffer solution, then buffer solution temperature is down to-2 DEG C;
(4) hydrogen peroxide is joined in step (3) gained buffer solution, continue stirring and obtain disinfectant solution in 1.3 hours;
(5) by step (4) gained disinfectant solution by filtering with microporous membrane, the aperture of microporous filter membrane is 0.30 μm, subpackage and get final product.
embodiment 5for the disinfectant solution cleaned a wound, take off the primary raw material stating weight proportion to be prepared from: take off the primary raw material stating weight proportion and be prepared from: benzalkonium chloride 2 grams, Radix Cirsii Japonici 5 grams, Radix Scutellariae 4 grams, Cacumen Platycladi preparata 5 grams, Flos Chrysanthemi Indici 3 grams, Fructus Gardeniae 8 grams, Flos Lonicerae 9 grams, water for injection 300 grams, hydrogen peroxide 4 grams.
The preparation method of the above-mentioned disinfectant solution for cleaning a wound, step is as follows:
(1) Flos Chrysanthemi Indici is placed in marmite, is dipped to the complete variable color of water with water for injection, filter, filtrate is for subsequent use, is exposed to the sun 5 days, the Flos Chrysanthemi Indici dried and Radix Cirsii Japonici, Radix Scutellariae, Cacumen Platycladi preparata, Fructus Gardeniae and Flos Lonicerae ethanol is mixed thoroughly under the Flos Chrysanthemi Indici after immersion is placed in daylight, stewing 15 hours, take out stand-by;
(2) joined in step (1) gained filtrate by step (1) gained crude drug, intense fire is fried open, and turns 30 minutes at a simmer, filters, and filtrate cooling is for subsequent use;
(3) step (3) gained filtrate and benzalkonium chloride are added in Agitation Tank, leave standstill after 2 hours, stir at 50 DEG C after 1 hour and obtain buffer solution, then buffer solution temperature is down to-2 DEG C;
(4) hydrogen peroxide is joined in step (3) gained buffer solution, continue stirring and obtain disinfectant solution in 1 hour;
(5) by step (4) gained disinfectant solution by filtering with microporous membrane, the aperture of microporous filter membrane is 0.22 μm, subpackage and get final product.
experimental example 1the clinical practice of disinfectant solution of embodiment 5 gained for cleaning a wound: 4 hospitals' screening 300 exception wounds.Operation etc. has the patient of wound.Be divided into experimental group and matched group, experimental group 200 people, matched group 100 people, experimental group uses the present embodiment 5 products obtained therefrom, and matched group uses other disinfectant solution (routine such as povidone iodine, ethanol, Gentian Violet is used for the disinfectant solution of wound disinfection).Using method: be poured on by disinfectant solution in clean container, is stained with disinfectant solution with clean cotton swab and cleans a wound.Curative effect situation criterion: recovery from illness: after using this product, through test, the antibacterials such as staphylococcus aureus, staphylococcus epidermidis, enterococcus disappear; Effective: after using this product, through test, the antibacterials such as staphylococcus aureus, staphylococcus epidermidis, enterococcus disappear to some extent; Invalid: after using this product, through test, the antibacterials such as staphylococcus aureus, staphylococcus epidermidis, enterococcus are all without disappearance.Result is as shown in table 1.
Table 1: the disinfectant solution bactericidal effect checking that embodiment 5 gained cleans a wound
Therapeutic effect: 46 examples (92%) of stopping blooding in using 3 minutes, effective 3 examples (6%), invalid 1 example (2%), total effective rate 98%, successful is better than matched group, uses the disinfectant solution of gained of the present invention for cleaning a wound, for general traumatic hemorrhage, blood will be stopped in 3 minutes, even if hemorrhage serious patient is in 5 minutes, also blood can be stopped.
Finally it should be noted that, embodiment is the detailed description of the invention of optimum of the present invention, be not limited to the present invention, although with reference to previous embodiment to invention has been detailed description, for a person skilled in the art, it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (2)
1. the disinfectant solution for cleaning a wound, is characterized in that, takes off the primary raw material stating weight proportion and is prepared from: benzalkonium chloride 1.5 grams, Radix Cirsii Japonici 4 grams, Radix Scutellariae 3 grams, Cacumen Platycladi preparata 4 grams, Flos Chrysanthemi Indici 2 grams, Fructus Gardeniae 6 grams, Flos Lonicerae 8 grams, water for injection 250 grams, hydrogen peroxide 3.5 grams.
2. the preparation method of disinfectant solution for cleaning a wound, step is as follows:
(1) Flos Chrysanthemi Indici is placed in marmite, is dipped to the complete variable color of water with water for injection, filter, filtrate is for subsequent use, is exposed to the sun 4.5 days, the Flos Chrysanthemi Indici dried and Radix Cirsii Japonici, Radix Scutellariae, Cacumen Platycladi preparata, Fructus Gardeniae and Flos Lonicerae ethanol is mixed thoroughly under the Flos Chrysanthemi Indici after immersion is placed in daylight, stewing 13 hours, take out stand-by;
(2) joined in step (1) gained filtrate by step (1) gained crude drug, intense fire is fried open, and turns 25 minutes at a simmer, filters, and filtrate cooling is for subsequent use;
(3) step (3) gained filtrate and benzalkonium chloride are added in Agitation Tank, leave standstill after 1.3 hours, stir at 45 DEG C after 0.8 hour and obtain buffer solution, then buffer solution temperature is down to-4 DEG C;
(4) hydrogen peroxide is joined in step (3) gained buffer solution, continue stirring and obtain disinfectant solution in 0.8 hour;
(5) by step (4) gained disinfectant solution by filtering with microporous membrane, the aperture of microporous filter membrane is 0.15 μm, subpackage and get final product.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410411600.7A CN104189162B (en) | 2014-08-20 | 2014-08-20 | For the thimerosal and the preparation method that clean a wound |
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| CN201410411600.7A Division CN104189162B (en) | 2014-08-20 | 2014-08-20 | For the thimerosal and the preparation method that clean a wound |
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| CN105194003A true CN105194003A (en) | 2015-12-30 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510656653.XA Withdrawn CN105194003A (en) | 2014-08-20 | 2014-08-20 | Disinfectant used for cleaning up wounds |
| CN201510658902.9A Withdrawn CN105267354A (en) | 2014-08-20 | 2014-08-20 | Sterilization liquid benefit for cleaning wound |
| CN201510656562.6A Withdrawn CN105267353A (en) | 2014-08-20 | 2014-08-20 | Sterilization liquid used for cleaning wound |
| CN201510660579.9A Withdrawn CN105194005A (en) | 2014-08-20 | 2014-08-20 | Disinfectant for cleaning up wounds |
| CN201410411600.7A Expired - Fee Related CN104189162B (en) | 2014-08-20 | 2014-08-20 | For the thimerosal and the preparation method that clean a wound |
| CN201510657075.1A Withdrawn CN105194004A (en) | 2014-08-20 | 2014-08-20 | Preparation method of disinfectant used for cleaning up wounds |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201510658902.9A Withdrawn CN105267354A (en) | 2014-08-20 | 2014-08-20 | Sterilization liquid benefit for cleaning wound |
| CN201510656562.6A Withdrawn CN105267353A (en) | 2014-08-20 | 2014-08-20 | Sterilization liquid used for cleaning wound |
| CN201510660579.9A Withdrawn CN105194005A (en) | 2014-08-20 | 2014-08-20 | Disinfectant for cleaning up wounds |
| CN201410411600.7A Expired - Fee Related CN104189162B (en) | 2014-08-20 | 2014-08-20 | For the thimerosal and the preparation method that clean a wound |
| CN201510657075.1A Withdrawn CN105194004A (en) | 2014-08-20 | 2014-08-20 | Preparation method of disinfectant used for cleaning up wounds |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106166244A (en) * | 2016-08-10 | 2016-11-30 | 李春燕 | A kind of Traditional Chinese medicine disinfectant and its preparation method and application |
| CN106943454A (en) * | 2017-03-30 | 2017-07-14 | 黑龙江童医生儿童生物制药有限公司 | A kind of disposable antibacterial spraying of plant type and preparation method thereof |
| CN107349253A (en) * | 2017-06-23 | 2017-11-17 | 苏州凌科特新材料有限公司 | Non-stimulated Medical antiseptic solution and preparation method thereof |
| CN113197048A (en) * | 2021-04-29 | 2021-08-03 | 李裕圆 | Planting method utilizing space on tree |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102772764A (en) * | 2012-07-19 | 2012-11-14 | 张吉玲 | Nursing traditional Chinese medicine disinfectant and preparation method |
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| CN1094207A (en) * | 1993-04-10 | 1994-10-26 | 张心玉 | Disinfecting cover for telephone |
| CN1123695A (en) * | 1995-12-04 | 1996-06-05 | 周凌煜 | Preparation of Paoxuanling for curing tinea |
| CN1380098A (en) * | 2002-05-20 | 2002-11-20 | 张勇飞 | Anti-infection compound preparation and its preparation method |
| AU2008338250B2 (en) * | 2007-12-17 | 2014-05-15 | Novapharm Research (Australia) Pty Ltd | Viricidal composition |
| CN102784350A (en) * | 2012-08-07 | 2012-11-21 | 孙雅儒 | Mite killing bactericide and preparation method of mite killing bactericide |
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2014
- 2014-08-20 CN CN201510656653.XA patent/CN105194003A/en not_active Withdrawn
- 2014-08-20 CN CN201510658902.9A patent/CN105267354A/en not_active Withdrawn
- 2014-08-20 CN CN201510656562.6A patent/CN105267353A/en not_active Withdrawn
- 2014-08-20 CN CN201510660579.9A patent/CN105194005A/en not_active Withdrawn
- 2014-08-20 CN CN201410411600.7A patent/CN104189162B/en not_active Expired - Fee Related
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102772764A (en) * | 2012-07-19 | 2012-11-14 | 张吉玲 | Nursing traditional Chinese medicine disinfectant and preparation method |
Non-Patent Citations (4)
| Title |
|---|
| 《中兽医医药杂志》 * |
| 《中国医药导报》 * |
| 《中国消毒学杂志》 * |
| 《北京中医药大学学报》 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104189162B (en) | 2016-05-04 |
| CN104189162A (en) | 2014-12-10 |
| CN105194005A (en) | 2015-12-30 |
| CN105194004A (en) | 2015-12-30 |
| CN105267354A (en) | 2016-01-27 |
| CN105267353A (en) | 2016-01-27 |
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Address after: 343000 Ji'an city of Jiangxi Province, Jizhou District No. 15 Shaoshan West Road, No. 2 building 2-102 Applicant after: Zhang Guangrong Address before: 250014 Shandong Province, Lixia District, Ji'nan City Road No. 26 Applicant before: Zhang Guangrong |
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