CN105167753A - Inclined plate type mechanical pain-sensitivity determining device - Google Patents
Inclined plate type mechanical pain-sensitivity determining device Download PDFInfo
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- CN105167753A CN105167753A CN201510656874.7A CN201510656874A CN105167753A CN 105167753 A CN105167753 A CN 105167753A CN 201510656874 A CN201510656874 A CN 201510656874A CN 105167753 A CN105167753 A CN 105167753A
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Abstract
The invention relates to an inclined plate type mechanical pain-sensitivity determining device which adopts the structure that the bottom side of a vertical plate is vertical to a horizontal plate; the horizontal plate and an inclined plate positioned above the horizontal plate are rotatably connected through a shaft lever; a wire mesh is arranged in the middle of the inclined plate; a magnet is positioned below the wire mesh, a probe is arranged on the magnet and extends out of the wire mesh; angle measuring scales are radially marked on the vertical plate from the left bottom corner to the right top corner. According to the invention, the defects in the prior art that the price is expensive, users are easy to suffer from cervical vertebra strain, the probe is easy to damage, and the pain-sensitivity threshold value of the bottom of only one paw can be determined once are overcome; the determining device has the advantages that the manufacture is simple; angle is used for grading pain degrees, can be directly used as a comparison parameter, and can be converted into force F for comparison according to the formula: F=0.25mgcos alpha, so that the determination accuracy is good; through the measurement of the weight of rats, the paw withdrawal mechanical threshold (the probe irritation force F) of rats can be accurately calculated; therefore, the determining device is applicable to the determination of mechanical pain threshold values of big and small animals.
Description
Technical field
The present invention relates to medical instruments field, particularly a kind of ramp type machinery pain sensitive detection device.
Background technology
Pain is divided into acute pain and chronic pain, one of acute pain guarding reflex belonging to body, but chronic pain a kind of morbid state performance often.Chronic pain often shows as hyperpathia and the paraesthesia of damage location and adjacent tissue, and chronic pain has the feature such as pathogenic factor and mechanism complexity, not easily alleviation, and the basic research for its mechanism and therapeutic strategy is study hotspot always.
The research of experimental chronic pain be unable to do without the mensuration to Pain behaviour, because pain is a kind of subjective feeling, animal can not be expressed pain and is subject to, and measure so usually relate to mechanical hyperalgesia and thermal hyperalgesia, wherein the mensuration of mechanical hyperalgesia is the most conventional.
Before making the present invention, at present, many use VonFrey carry out the quick monitoring of machinery pain, its principle is that rat is placed in ferrum on the net, the probe tip of machine is aimed at rat sole, vertically upward slow jack-up, until rat sole reflexive is lifted, dynamics during machine display contracting foot, be the sufficient threshold value of machinery contracting, the less explanation of this value more bitterly.Although its mensuration is highly sensitive, there is serious defect: 1. price is high, ready availability difference; 2. the easy cervical vertebra strain of user: because observer needs constantly at grid bottom alignment sole, turning one's head for a long time and facing upward to form cervical vertebra strain; 3. probe rapid wear, probe is bad to be belonged to the sensitivity that fine features determines machine and easily damages, and maintenance cost is high.4. the disposable quick threshold value of pain that can only measure a vola, can not obtain the quick threshold value of pain of to be measured group and matched group in pairs, therefore, a kind of ready availability good, assay method is simple and easy, the development of hommization and high efficiency device just necessitates.
Summary of the invention
Object of the present invention is just to overcome above-mentioned defect, develops a kind of ramp type machinery pain sensitive detection device.
Technical scheme of the present invention is:
A kind of ramp type machinery pain sensitive detection device, its technical characteristics is that perpendicular plate base is vertical with horizontal plate, horizontal plate is connected by spindle rotation with the swash plate of top, in the middle of swash plate, wire gauze is set, Magnet is below wire gauze, Magnet arranges probe, and probe leans out from wire gauze, perpendicular plate is starting point radially indicates angle measuring calibration to the upper right corner with the lower left corner.
Described probe is that nonmagnetic substance is made.
The base of described perpendicular plate and the inside flush left of horizontal plate, the aligned of the upper surface when horizontal base line on scale and swash plate are set level.
Be empty in the middle of described swash plate, wire gauze covers the space of this sky.
Advantage of the present invention and beneficial effect are:
1. described in, determinator preparation is simple, and material requested is ready availability good, and hard plate used, wire gauze, Magnet are articles for daily use;
2. the Hyperalgesia degree that device described in can be used for measuring rat extremity has two available parameter indexs: angle [alpha] and dynamics F.1) pain degree classification is carried out with angle: the stimulation dynamics of probe to the tested facies palmaris of rat increases along with the reduction of swash plate angle, if the angle recorded is larger, illustrate that animal is more responsive to pain, its effect can meet experiment demand, alternative existing high gauge, is expected to reduce experimental cost; 2) described angle [alpha] both directly can be used as and compare parameter, also can be converted into dynamics F=0.25mgcos α and compare;
3. it is good that device described in measures accuracy, and the machinery that accurately can calculate rat by measuring the body weight of rat contracts sufficient threshold value (the dynamics F that probe stimulates).
4. described in, device is simple to operate, only needs rat to be placed ferrum online, in position, vola to be measured adsorption magnet, slowly reduces swash plate angle, and when rat occurs to contract foot, the angle of perpendicular plate reflects the sufficient threshold value of current contracting.
5. the method for this mensuration grip force is applied to the mensuration of the mechanical pain thresholds being applicable to large and small animal, is worthy of popularization.
Accompanying drawing illustrates:
Fig. 1---structural principle schematic diagram of the present invention.
In figure, each label represents that corresponding component names is as follows:
Perpendicular plate 1, swash plate 2, axostylus axostyle 3; Horizontal plate 4, Magnet 5, wire gauze 6, probe 7.
Detailed description of the invention:
As shown in Figure 1:
The present invention is made up of perpendicular plate 1, swash plate 2, Magnet 5, wire gauze 6, probe 7, axostylus axostyle 3, horizontal plate 4.Wherein, perpendicular plate 1 base be connected as one structure vertical with horizontal plate 4, horizontal plate 4 is rotationally connected into " loose-leaf " structure with the swash plate 2 of top by axostylus axostyle 3, and Magnet 5, below wire gauze 6, Magnet 5 is arranged probe 7, and probe 7 leans out from wire gauze 6.
Described perpendicular plate 1 is that starting point radially indicates angle measuring calibration to the upper right corner with the lower left corner, for measuring the place angle of swash plate 2; The base of described perpendicular plate 1 and the inside flush left of horizontal plate 4, the aligned of the upper surface when horizontal base line on scale and swash plate 2 are set level;
Described wire gauze 6 is for being positioned at swash plate 2 central authorities, and be namely empty in the middle of swash plate 2, swash plate 2 is hardboard, and wire gauze 6 is covered with the region of this sky; Described swash plate 2 smooth surface, can be limited to wire gauze 6 region by the range of activity of rat on swash plate 2, because under normal circumstances, rat will automatically slide into or return middle wire gauze 6 region because of the force of borrowing do not grasped on smooth swash plate 2.
The length of the mesh aperture of described wire gauze 6 and to be widely all limited between 3 ~ 4mm, to ensure that rat facies palmaris is uniformly distributed on wire gauze 6, described wire gauze 6 is when meeting hardness requirement, the diameter of iron wire should be little as much as possible, can ensure that wire gauze 6 and swash plate 2 are at same plane on the one hand, being convenient to wire gauze carries out stimulation applications 6 times on the other hand;
Described stimulation parts are made up of Magnet 5 and probe 7, and probe 7 above is vertically fixed on the upper surface of Magnet 5, and the upper surface of described Magnet 5 is smooth flat, are adsorbed in wire gauze 6 and can ensure that probe 7 is perpendicular to ferrum net below; The length of described probe 7 just slightly exposes the surface of wire gauze 6, for stimulating the vola of tested rat.Described probe 7 is made for nonmagnetic metal, and must have certain degree of hardness, to ensure to be adsorbed on wire gauze 6; The top of described probe 7 is blunt nosed design, reduces the sharp instrument injury to In The Rat Sole.Described Magnet 5 should be not less than 50g with the absorption strength of wire gauze 6, if the vola of too low rat can make the stimulation degree of depth of probe 7 be shifted, the stimulation of probe 7 is lowered.
When using the present invention to measure the sufficient threshold value of machinery contracting, before enforcement, complete the connection as Fig. 1.
Application process of the present invention illustrates:
The present invention is applicable to two kinds of using forestland, can be divided into angle [alpha] parameter using forestland (sxemiquantitative) and stimulate dynamics F using forestland (quantitatively).In addition, the quick threshold value of pain of all right Simultaneously test more than one group.
Embodiment 1:
Angle [alpha] parameter using forestland (for rat)
(1), when using this measurement device pain quick, the horizontal plate 4 of device is lain against desktop, and it is initial angle (for 80 °) that wire gauze 6 arranges a maximum angle, is placed by rat on wire gauze 6, and rat can tightly be held wire gauze 6 not landing;
(2) when rat is motionless, at its tested vola (for left back vola) adsorption magnet 5, make the probe 7 perpendicular alignmnet vola above Magnet 5 and contact, if now rat would not be moved bitterly, namely can to lower gradually the angle of swash plate 2, slowly can increase probe 7 like this and stimulate dynamics; Once rat lifts foot, pain is described, fixing swash plate 2, now swash plate 2 angle [alpha] corresponded on perpendicular plate 1 just reflects its pain threshold.
Embodiment 2:
Stimulation dynamics F using forestland (for rat)
(1) need rat weight to be measured before using this device to measure, quality is m;
(2) measure constantly, the horizontal plate 4 of device is lain against desktop, and it is initial angle (for 80 °) that wire gauze 6 arranges a maximum angle, is placed by rat on wire gauze 6, and rat can tightly be held wire gauze 6 not landing;
(3) when rat is motionless, at its tested vola (for left back vola) adsorption magnet 5, probe 7 now above Magnet 5 just perpendicular alignmnet vola contacting, if rat would not be moved bitterly, then to lower gradually the angle [alpha] of swash plate 2, along with the reduction of angle [alpha], cos α can increase, so the stimulation dynamics F=0.25mgcos α in probe 7 pairs of volas can increase gradually; Once rat lifts foot, pain is described, fixing swash plate 2, records the angle [alpha] on the perpendicular plate 1 of now swash plate 2 correspondence.
(4) can mechanical threshold be scaled according to angle: F=0.25mgcos α, the threshold of pain of the different rat of Quantitative Comparison can be carried out like this.
Embodiment 3:
The using forestland (to survey at the bottom of 2 metapedes) of Simultaneously test more than one group data
(1), when using this measurement device pain quick, the horizontal plate 4 of device is lain against desktop, and it is initial angle (for 80 °) that wire gauze 6 arranges a maximum angle, is placed by rat on wire gauze 6, and rat can tightly be held wire gauze 6 not landing;
(2) when rat is motionless, the each adsorption magnet of the wire gauze 6 of (homonymy and offside) 5 one pieces at the bottom of its tested metapedes, make the probe 7 perpendicular alignmnet vola above Magnet 5 and contact, if now rat would not be moved bitterly, to lower gradually the angle [alpha] of swash plate 2, along with the reduction of angle [alpha], cos α can increase, so the stimulation dynamics F=0.25mgcos α in probe 7 pairs of volas can increase gradually; Once rat homonymy lifts foot, homonymy vola pain is described, fixing swash plate 2, now the angle [alpha] 1 of swash plate 2 correspondence just reflects the pain threshold in homonymy vola; Remove the Magnet 5 of homonymy, the method continuing decline swash plate 2 can draw again the angle [alpha] 2 that the threshold of pain of offside is corresponding, compares the self-contrast that α 1 and α 2 just can carry out homonymy, the threshold of pain, offside vola.
To sum up, the inventive method is simple and easy, be conducive to the cost reducing pain mechanical hyperalgesia threshold value determination, research funding can be saved and purchasing the expenditure in high equipment, the efficiency of measuring can also be improved, be conducive to the further genralrlization of pain research in the long term, meet the needs of innovation drive-type Preclinic and clinic medical treatment development.
Claims (4)
1. a ramp type machinery pain sensitive detection device, it is characterized in that perpendicular plate base is vertical with horizontal plate, horizontal plate is connected by spindle rotation with the swash plate of top, in the middle of swash plate, wire gauze is set, Magnet is below wire gauze, Magnet arranges probe, and probe leans out from wire gauze, perpendicular plate is starting point radially indicates angle measuring calibration to the upper right corner with the lower left corner.
2. a kind of ramp type machinery pain sensitive detection device according to claim 1, is characterized in that described probe is that nonmagnetic substance is made.
3. a kind of ramp type machinery pain sensitive detection device according to claim 1, is characterized in that the base of described perpendicular plate and the inside flush left of horizontal plate, the aligned of the upper surface when horizontal base line on scale and swash plate are set level.
4. a kind of ramp type machinery pain sensitive detection device according to claim 1, it is characterized in that in the middle of described swash plate be empty, wire gauze covers the space of this sky.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201510656874.7A CN105167753B (en) | 2015-10-12 | 2015-10-12 | A kind of ramp type machinery pain sensitive detection device |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510656874.7A CN105167753B (en) | 2015-10-12 | 2015-10-12 | A kind of ramp type machinery pain sensitive detection device |
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| CN105167753A true CN105167753A (en) | 2015-12-23 |
| CN105167753B CN105167753B (en) | 2017-12-29 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023070701A1 (en) * | 2021-10-29 | 2023-05-04 | 中山大学 | Automatic animal pain test system |
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| CN204654885U (en) * | 2014-11-28 | 2015-09-23 | 叶宁 | Contact pilotage induced pain biological function experiment dolorimeter |
| CN205054169U (en) * | 2015-10-12 | 2016-03-02 | 南京大学医学院附属鼓楼医院 | Quick survey device of ramp type machinery grief |
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2015
- 2015-10-12 CN CN201510656874.7A patent/CN105167753B/en not_active Expired - Fee Related
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060178596A1 (en) * | 2005-01-25 | 2006-08-10 | University Of Massachusetts | Cutaneous indentation sensory testing device |
| WO2010024492A1 (en) * | 2008-08-27 | 2010-03-04 | Vivozon, Inc. | The measuring device of pain reaction for experimental animals |
| US8944008B2 (en) * | 2011-04-08 | 2015-02-03 | Topcat Metrology Limited | Force measurement |
| CN104545798A (en) * | 2013-10-11 | 2015-04-29 | 济南益延科技发展有限公司 | Rat and mouse pelma pain threshold detector |
| CN203523524U (en) * | 2013-10-30 | 2014-04-09 | 赵京杰 | Experimental animal muscle force detection device |
| CN104095614A (en) * | 2014-07-10 | 2014-10-15 | 中国人民解放军第四军医大学 | Rat balance based multifunctional pain threshold measuring apparatus and method |
| CN204654885U (en) * | 2014-11-28 | 2015-09-23 | 叶宁 | Contact pilotage induced pain biological function experiment dolorimeter |
| CN204520626U (en) * | 2014-12-29 | 2015-08-05 | 首都医科大学宣武医院 | Marking device capable of measuring length, angle and pain score |
| CN204600776U (en) * | 2015-04-23 | 2015-09-02 | 王永滨 | Warm-keeping device is fixed in a kind of handstand for mouse experiment |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2023070701A1 (en) * | 2021-10-29 | 2023-05-04 | 中山大学 | Automatic animal pain test system |
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