CN105148812A - Treatment device and treatment method for laboratory liquid preparation - Google Patents
Treatment device and treatment method for laboratory liquid preparation Download PDFInfo
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- CN105148812A CN105148812A CN201510444434.5A CN201510444434A CN105148812A CN 105148812 A CN105148812 A CN 105148812A CN 201510444434 A CN201510444434 A CN 201510444434A CN 105148812 A CN105148812 A CN 105148812A
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Abstract
The invention discloses a treatment device for a laboratory liquid preparation. The treatment device mainly comprises a first liquid storage bottle, a second liquid storage bottle, a vacuum pump, an oxygen content determinator, a first hose, a second hose, a third hose, a fourth hose and a subpackaging mechanism, wherein the first liquid storage bottle and the second liquid storage bottle are connected through the fourth hose and are connected with one end of the third hose respectively through the first hose and the second hose, the other end of the third hose is connected to the vacuum pump, the content of oxygen in the second liquid storage bottle is measured by the oxygen content determinator, and the subpackaging mechanism is connected with the second liquid storage bottle. Meanwhile, the invention also provides a treatment method for the laboratory liquid preparation. According to the treatment device and the treatment method, three steps, i.e., filtering, low-oxygen treatment and subpackaging are integrated, so that influence caused by outside air can be avoided during operation, the oxygen removal effect of low-oxygen treatment is improved, and the stability of the liquid preparation is guaranteed.
Description
Technical field
The present invention relates to laboratory treatment liquid preparation technology, specifically a kind for the treatment of apparatus of laboratory liquid body preparation and processing method.
Background technology
Oxygen content in solution can affect the stability of Liquid drug preparation, particularly for the medicine of easily oxidation, has obvious impact.As some biologic products such as vitamin C injection, protein-based liquid preparation.It is add antioxidant in the formulation that the method improving oxidizable drug substance stable mainly contains two: one; Two is the oxygen content reduced by physical method in solution.For the pharmaceutical preparation that some is not suitable for adding antioxidant, unique method is the oxygen content reduced by physical method in solution, to improve the stability of pharmaceutical preparation.In laboratory, the process of liquid preparation is generally filtered, hypoxemia process, these three steps of packing, thus make the solution finally obtained have lower oxygen content, to ensure the stability of solution.At present, laboratory carries out filtering for liquid preparation, hypoxemia process and packing time, these three steps are separately carried out, thus poor to the deaerating effect of liquid preparation when causing hypoxemia process.Meanwhile, during three step separate operation, its complex operation step, affects speed of experiment.
Summary of the invention
The object of the invention is to overcome the deficiency that above prior art exists, provide the treating apparatus of laboratory liquid body preparation that a kind of structure is simple, can make filtration, hypoxemia process and packing integration.Present invention also offers a kind of processing method for the treatment of apparatus of laboratory liquid body preparation simultaneously.
In order to achieve the above object, the present invention is by the following technical solutions: a kind for the treatment of apparatus of laboratory liquid body preparation, comprise the first liquid storage bottle, the second liquid storage bottle, vavuum pump, determination of oxygen content instrument, the first flexible pipe, the second flexible pipe, the 3rd flexible pipe, the 4th flexible pipe and body-packing, the top of the first liquid storage bottle is inserted in one end of described first flexible pipe, the top of the second liquid storage bottle is inserted in one end of described second flexible pipe, the other end of described first flexible pipe is all connected with one end of the 3rd flexible pipe with the other end of the second flexible pipe, and the other end of described 3rd flexible pipe is connected with vavuum pump; The bottom of the first liquid storage bottle is inserted in one end of described 4th flexible pipe, and the other end of described 4th flexible pipe inserts the top of the second liquid storage bottle; Described first flexible pipe, the 3rd flexible pipe and the 4th flexible pipe are respectively equipped with the first switch, second switch and the 3rd switch; Described 4th flexible pipe is provided with the first filter, and described determination of oxygen content instrument is connected with the second liquid storage bottle; Described first liquid storage bottle is connected with the five weaknesses pipe for supplying protective gas, and described five weaknesses pipe is provided with the 4th switch.
Described body-packing comprise sub-bottling, the 6th flexible pipe, for supplying the 7th flexible pipe of protective gas and syringe needle in parallel; one end of described 6th flexible pipe is all connected with sub-bottling by syringe needle in parallel with one end of the 7th flexible pipe; the other end of described 6th flexible pipe inserts the bottom of the second liquid storage bottle, and described 6th flexible pipe and the 7th flexible pipe are respectively equipped with the 5th switch and the 6th switch.
The other end of described first flexible pipe and the other end of the second flexible pipe are all connected by three-way connection one end with the 3rd flexible pipe.
The treating apparatus of described laboratory liquid body preparation also comprises the first agitator and the second agitator, described first agitator comprises the first stirrer and first and stirs body, described first stirrer is placed in the first liquid storage bottle, described first stirs body is installed on the below of the first liquid storage bottle, and described first stirrer and first stirs body is connected; Described second agitator comprises the second stirrer and second and stirs body, and described second stirrer is placed in the second liquid storage bottle, and described second stirs body is installed on the below of the second liquid storage bottle, and described second stirrer and second stirs body is connected.
Described first liquid storage bottle comprises the first bottle and the first bottle cap, described first bottle cap is connected to the bottleneck of the first bottle, be provided with the first pad and the first connecting plate from bottom to top successively between the bottleneck of described first bottle and the first bottle cap, the first bottle is inserted through after the first bottle cap, the first connecting plate and the first pad all successively in one end of one end of described first flexible pipe, one end of the 4th flexible pipe and five weaknesses pipe.
Described second liquid storage bottle comprises the second bottle and the second bottle cap, described second bottle cap is connected to the bottleneck of the second bottle, be provided with the second pad and the second connecting plate from bottom to top successively between the bottleneck of described second bottle and the second bottle cap, one end of described second flexible pipe and the other end of the 4th flexible pipe insert the second bottle through after the second bottle cap, the second connecting plate and the second pad all successively.
Described first flexible pipe, the 3rd flexible pipe, five weaknesses pipe and the 7th flexible pipe are equipped with the second filter.
Based on a processing method for the treating apparatus of above-mentioned laboratory liquid body preparation, comprise the following steps:
1) filter: first close the first switch, the 5th switch and the 6th switch, open second switch, the 3rd switch and the 4th switch again, then vavuum pump is opened, thus by the solution extraction in the first liquid storage bottle to the second liquid storage bottle, and this solution arrives the process of the second liquid storage bottle by the first metre filter from the first liquid storage bottle;
2) hypoxemia process: comprise the following steps:
A, first close the first switch, the 3rd switch, the 4th switch, the 5th switch and the 6th switch, open second switch, then open vavuum pump, the second liquid storage bottle is vacuumized;
B, complete and vacuumize after, close second switch, then open the first switch and the 4th switch, then logical five weaknesses pipe leads to protective gas to the second liquid storage bottle;
C, repetition steps A and step B for several times, thus make the numerical value that determination of oxygen content instrument reaches required;
3) packing: comprise the following steps:
A, first close the first switch, second switch, the 3rd switch, the 4th switch and the 5th switch, open the 6th switch, then logical 7th flexible pipe leads to protective gas to sub-bottling;
After b, sub-bottling are full of protective gas, close second switch, the 3rd switch and the 6th switch, open the first switch, the 4th switch and the 5th switch, then logical five weaknesses pipe leads to protective gas to the second liquid storage bottle and makes to form malleation in the second liquid storage bottle and transfer in sub-bottling by liquid by the 6th flexible pipe, and loading amount closes all switches after the volume fixed;
C, will be equipped with liquid sub-bottling sealing preserve.
Described protective gas in step B and step a is a kind of in nitrogen, helium and carbon dioxide.
In step C, it is 0-20% that determination of oxygen content instrument reaches required numerical value.And further preferred, it is 5-15% that determination of oxygen content instrument reaches required numerical value.
The present invention, relative to prior art, has following advantage and effect:
1, the treating apparatus of laboratory liquid body preparation of the present invention is formed primarily of the first liquid storage bottle, the second liquid storage bottle, vavuum pump, determination of oxygen content instrument, the first flexible pipe, the second flexible pipe, the 3rd flexible pipe, the 4th flexible pipe and body-packing, it can make this three steps integration of filtration, hypoxemia process and packing, this can be avoided the impact of outside air in operation, improve the deaerating effect of hypoxemia process, ensure that the stability of liquid preparation.
2, the present invention makes this three steps integration of filtration, hypoxemia process and packing, avoids being subject to ectocine in operating, thus can realize the preparation of sterile sampling.
3, the present invention will filter, this three steps integration of hypoxemia process and packing, this simplify operation, improve speed of experiment.
Accompanying drawing explanation
Fig. 1 is a kind of overall structure schematic diagram for the treatment of apparatus of laboratory liquid body preparation.
Detailed description of the invention
For ease of it will be appreciated by those skilled in the art that the present invention is described in further detail below in conjunction with drawings and Examples.
Embodiment 1
A kind for the treatment of apparatus of laboratory liquid body preparation, comprise the first liquid storage bottle 1, second liquid storage bottle 2, vavuum pump 3, determination of oxygen content instrument 4, first flexible pipe 5, second flexible pipe 6, the 3rd flexible pipe 7, the 4th flexible pipe 8 and body-packing 9, the top of the first liquid storage bottle 1 is inserted in one end of described first flexible pipe 5, the top of the second liquid storage bottle 2 is inserted in one end of described second flexible pipe 6, the other end of described first flexible pipe 5 is all connected with one end of the 3rd flexible pipe 7 with the other end of the second flexible pipe 6, and the other end of described 3rd flexible pipe 7 is connected with vavuum pump 3; The bottom of the first liquid storage bottle 1 is inserted in one end of described 4th flexible pipe 8, and the other end of described 4th flexible pipe 8 inserts the top of the second liquid storage bottle 2; Described first flexible pipe 5, the 3rd flexible pipe 7 and the 4th flexible pipe 8 are respectively equipped with the first switch 19, second switch 10 and the 3rd switch 11; Described 4th flexible pipe 8 is provided with the first filter 12, and described determination of oxygen content instrument 4 is connected with the second liquid storage bottle 2; Described first liquid storage bottle 1 is connected with the five weaknesses pipe 13 for supplying protective gas, and described five weaknesses pipe 13 is provided with the 4th switch 14.
Described body-packing 9 comprise sub-bottling 901, the 6th flexible pipe 902, for supplying the 7th flexible pipe 903 and the syringe needle in parallel 904 of protective gas; one end of described 6th flexible pipe 902 is all connected with sub-bottling 901 by syringe needle 904 in parallel with one end of the 7th flexible pipe 903; the other end of described 6th flexible pipe 902 inserts the bottom of the second liquid storage bottle 2, and described 6th flexible pipe 902 and the 7th flexible pipe 903 are respectively equipped with the 5th switch 905 and the 6th switch 906.
Concrete, in the present embodiment, the first liquid storage bottle 1 and the second liquid storage bottle 2 all adopt Xiao Te
laboratory vials; First flexible pipe 5, second flexible pipe 6, the 3rd flexible pipe 7, the 4th flexible pipe 8, described five weaknesses pipe 13, the 6th flexible pipe 902 and the 7th flexible pipe 903 are pharmaceutical grade plastic flexible pipe; First switch 19, second switch 10, the 3rd switch 11, the 4th switch 14, the 5th switch 905 and the 6th switch 906 all adopt stainless steel flexible hose clip; Sub-bottling 901 adopts cillin bottle.
The other end of described first flexible pipe 5 is all connected by three-way connection 15 one end with the 3rd flexible pipe 7 with the other end of the second flexible pipe 6.Concrete, three-way connection 15 is stainless steel three-way connection, and this structure is simple, and makes the connection sealing between the first flexible pipe 5, second flexible pipe 6 and the 3rd flexible pipe 7, ensures the reliability of experiment.
The treating apparatus of described laboratory liquid body preparation also comprises the first agitator 16 and the second agitator 17, described first agitator 16 comprises the first stirrer 1601 and first and stirs body 1602, described first stirrer 1601 is placed in the first liquid storage bottle 1, described first stirs body 1602 is installed on the below of the first liquid storage bottle 1, and described first stirrer 1601 and first stirs body 1602 is connected; Described second agitator 17 comprises the second stirrer 1701 and second and stirs body 1702, described second stirrer 1701 is placed in the second liquid storage bottle 2, described second stirs body 1702 is installed on the below of the second liquid storage bottle 2, and described second stirrer 1701 and second stirs body 1702 is connected.First agitator 16 and the second agitator 17 are magnetic stirring apparatus.Stir body with between stirrer for magnetic force is connected.
Described first liquid storage bottle 1 comprises the first bottle 101 and the first bottle cap 102, described first bottle cap 102 is connected to the bottleneck of the first bottle 101, be provided with the first pad 103 and the first connecting plate 104 between the bottleneck of described first bottle 101 and the first bottle cap 102 from bottom to top successively, the first bottle 101 is inserted through after the first bottle cap 102, first connecting plate 104 and the first pad 103 all successively in one end of one end of described first flexible pipe 5, one end of the 4th flexible pipe 8 and five weaknesses pipe 13.First connecting plate 104 is corrosion resistant plate, and it ensures that each flexible pipe inserts stability in the first liquid storage bottle 1; And pad ensure that the sealing of the first liquid storage bottle 1.
Described second liquid storage bottle 2 comprises the second bottle 201 and the second bottle cap 202, described second bottle cap 202 is connected to the bottleneck of the second bottle 201, be provided with the second pad 203 and the second connecting plate 204 between the bottleneck of described second bottle 201 and the second bottle cap 202 from bottom to top successively, one end of described second flexible pipe 6 and the other end of the 4th flexible pipe 8 insert the second bottle 201 through after the second bottle cap 202, second connecting plate 204 and the second pad 203 all successively.Second connecting plate 204 is corrosion resistant plate, and it ensures that each flexible pipe inserts stability in the second liquid storage bottle 2; And pad ensure that the sealing of the second liquid storage bottle 2.
Described first flexible pipe 5, the 3rd flexible pipe 7, five weaknesses pipe 13 and the 7th flexible pipe 903 are equipped with the second filter 18.
Based on a processing method for the treating apparatus of above-mentioned laboratory liquid body preparation, comprise the following steps:
1) filter: first close the first switch, the 5th switch and the 6th switch, open second switch, the 3rd switch and the 4th switch again, then vavuum pump is opened, thus by the solution extraction in the first liquid storage bottle to the second liquid storage bottle, and this solution arrives the process of the second liquid storage bottle by the first metre filter from the first liquid storage bottle;
2) hypoxemia process: comprise the following steps:
A, first close the first switch, the 3rd switch, the 4th switch, the 5th switch and the 6th switch, open second switch, then open vavuum pump, the second liquid storage bottle is vacuumized;
B, complete and vacuumize after, close second switch, then open the first switch and the 4th switch, then logical five weaknesses pipe leads to protective gas to the second liquid storage bottle;
C, repetition steps A and step B for several times, thus make the numerical value that determination of oxygen content instrument reaches required;
3) packing: comprise the following steps:
A, first close the first switch, second switch, the 3rd switch, the 4th switch and the 5th switch, open the 6th switch, then logical 7th flexible pipe leads to protective gas to sub-bottling;
After b, sub-bottling are full of protective gas, close second switch, the 3rd switch and the 6th switch, open the first switch, the 4th switch and the 5th switch, then logical five weaknesses pipe leads to protective gas to the second liquid storage bottle and makes to form malleation in the second liquid storage bottle and transfer in sub-bottling by liquid by the 6th flexible pipe, and loading amount closes all switches after the volume fixed;
C, will be equipped with liquid sub-bottling sealing preserve.
When needs fill many bottles of liquid, only repeat above-mentioned steps a, b and c.
Described protective gas in step B and step a is the one in nitrogen, helium and carbon dioxide.
In step C, it is 5% that determination of oxygen content instrument reaches required numerical value.
Concrete, at the environment of B level clean area, (temperature is 18 DEG C ~ 26 DEG C to the treating apparatus of the laboratory liquid body preparation of the present embodiment, relative humidity is 45% ~ 65 DEG C, and pressure reduction relatively outdoor is greater than 10PA) in, respectively following sample to be filtered, hypoxemia process and packaging operation.The water of sample 1:500ml; Sample 2:500ml is containing the aqueous solution of 10% glycerine; Sample 3:500ml1% vitamin c solution; Sample 4:500ml5% Bovine Serum Albumin in Aqueous Solution; The sample 5:500ml cell culture medium aqueous solution.Be divided in every bottle of 5ml in the cillin bottle of 10ml specification, and coherent detection is carried out to the water in final cillin bottle.As shown in table 1, the oxygen content in solution can be reduced about 80% in the present embodiment.
Table 1
In above-mentioned table 1:
Oxygen content is the percentage of oxygen content in oxygen content and air in solution, makes oxygen content in air be 100%;
Oxygen content × 100% before deoxidize rate=(before process oxygen content-finished product oxygen content)/process.
Embodiment 2
The processing method of the treating apparatus of this laboratory liquid body preparation except following technical characteristic with embodiment 1: in step C, it is 10% that determination of oxygen content instrument reaches required numerical value.
Embodiment 3
The processing method of the treating apparatus of this laboratory liquid body preparation except following technical characteristic with embodiment 1: in step C, it is 15% that determination of oxygen content instrument reaches required numerical value.
Above-mentioned detailed description of the invention is the preferred embodiments of the present invention, can not limit the present invention, and any of other does not deviate from technical scheme of the present invention and the substitute mode of the change made or other equivalence, is included within protection scope of the present invention.
Claims (10)
1. the treating apparatus of a laboratory liquid body preparation, it is characterized in that: comprise the first liquid storage bottle, the second liquid storage bottle, vavuum pump, determination of oxygen content instrument, the first flexible pipe, the second flexible pipe, the 3rd flexible pipe, the 4th flexible pipe and body-packing, the top of the first liquid storage bottle is inserted in one end of described first flexible pipe, the top of the second liquid storage bottle is inserted in one end of described second flexible pipe, the other end of described first flexible pipe is all connected with one end of the 3rd flexible pipe with the other end of the second flexible pipe, and the other end of described 3rd flexible pipe is connected with vavuum pump; The bottom of the first liquid storage bottle is inserted in one end of described 4th flexible pipe, and the other end of described 4th flexible pipe inserts the top of the second liquid storage bottle; Described first flexible pipe, the 3rd flexible pipe and the 4th flexible pipe are respectively equipped with the first switch, second switch and the 3rd switch; Described 4th flexible pipe is provided with the first filter, and described determination of oxygen content instrument is connected with the second liquid storage bottle; Described first liquid storage bottle is connected with the five weaknesses pipe for supplying protective gas, and described five weaknesses pipe is provided with the 4th switch.
2. the treating apparatus of laboratory liquid body preparation according to claim 1; it is characterized in that: described body-packing comprise sub-bottling, the 6th flexible pipe, for supplying the 7th flexible pipe of protective gas and syringe needle in parallel; one end of described 6th flexible pipe is all connected with sub-bottling by syringe needle in parallel with one end of the 7th flexible pipe; the other end of described 6th flexible pipe inserts the bottom of the second liquid storage bottle, and described 6th flexible pipe and the 7th flexible pipe are respectively equipped with the 5th switch and the 6th switch.
3. the treating apparatus of laboratory liquid body preparation according to claim 1, is characterized in that: the other end of described first flexible pipe and the other end of the second flexible pipe are all connected by three-way connection one end with the 3rd flexible pipe.
4. the treating apparatus of laboratory liquid body preparation according to claim 1, it is characterized in that: also comprise the first agitator and the second agitator, described first agitator comprises the first stirrer and first and stirs body, described first stirrer is placed in the first liquid storage bottle, described first stirs body is installed on the below of the first liquid storage bottle, and described first stirrer and first stirs body is connected; Described second agitator comprises the second stirrer and second and stirs body, and described second stirrer is placed in the second liquid storage bottle, and described second stirs body is installed on the below of the second liquid storage bottle, and described second stirrer and second stirs body is connected.
5. the treating apparatus of laboratory liquid body preparation according to claim 1, it is characterized in that: described first liquid storage bottle comprises the first bottle and the first bottle cap, described first bottle cap is connected to the bottleneck of the first bottle, be provided with the first pad and the first connecting plate from bottom to top successively between the bottleneck of described first bottle and the first bottle cap, the first bottle is inserted through after the first bottle cap, the first connecting plate and the first pad all successively in one end of one end of described first flexible pipe, one end of the 4th flexible pipe and five weaknesses pipe.
6. the treating apparatus of laboratory liquid body preparation according to claim 1, it is characterized in that: described second liquid storage bottle comprises the second bottle and the second bottle cap, described second bottle cap is connected to the bottleneck of the second bottle, successively from upper and be provided with the second pad and the second connecting plate between the bottleneck of described second bottle and the second bottle cap, one end of described second flexible pipe and the other end of the 4th flexible pipe insert the second bottle through after the second bottle cap, the second connecting plate and the second pad all successively.
7. the treating apparatus of laboratory liquid body preparation according to claim 1, is characterized in that: described first flexible pipe, the 3rd flexible pipe, five weaknesses pipe and the 7th flexible pipe are equipped with the second filter.
8., based on a processing method for the treating apparatus of laboratory liquid body preparation according to claim 2, it is characterized in that, comprise the following steps:
1) filter: first close the first switch, the 5th switch and the 6th switch, open second switch, the 3rd switch and the 4th switch again, then vavuum pump is opened, thus by the solution extraction in the first liquid storage bottle to the second liquid storage bottle, and this solution arrives the process of the second liquid storage bottle by the first metre filter from the first liquid storage bottle;
2) hypoxemia process: comprise the following steps:
A, first close the first switch, the 3rd switch, the 4th switch, the 5th switch and the 6th switch, open second switch, then open vavuum pump, the second liquid storage bottle is vacuumized;
B, complete and vacuumize after, close second switch, then open the first switch and the 4th switch, then logical five weaknesses pipe leads to protective gas to the second liquid storage bottle;
C, repetition steps A and step B for several times, thus make the numerical value that determination of oxygen content instrument reaches required;
3) packing: comprise the following steps:
A, first close the first switch, second switch, the 3rd switch, the 4th switch and the 5th switch, open the 6th switch, then logical 7th flexible pipe leads to protective gas to sub-bottling;
After b, sub-bottling are full of protective gas, close second switch, the 3rd switch and the 6th switch, open the first switch, the 4th switch and the 5th switch, then logical five weaknesses pipe leads to protective gas to the second liquid storage bottle and makes to form malleation in the second liquid storage bottle and transfer in sub-bottling by liquid by the 6th flexible pipe, and loading amount closes all switches after the volume fixed;
C, will be equipped with liquid sub-bottling sealing preserve.
9. the processing method of the treating apparatus of laboratory liquid body preparation according to claim 8, is characterized in that: the described protective gas in step B and step a is a kind of in nitrogen, helium and carbon dioxide.
10. the processing method of the treating apparatus of laboratory liquid body preparation according to claim 8, is characterized in that: in step C, and it is 0-20% that determination of oxygen content instrument reaches required numerical value.
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| CN201510444434.5A CN105148812B (en) | 2015-07-24 | 2015-07-24 | Treatment device and treatment method for laboratory liquid preparation |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112108100A (en) * | 2020-10-23 | 2020-12-22 | 山东诺为制药流体系统有限公司 | Baffle box and reactor |
| CN115232713A (en) * | 2022-09-02 | 2022-10-25 | 安徽大学 | Portable laboratory simple and easy device of oxygen in getting rid of culture medium |
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| CN201855700U (en) * | 2010-10-09 | 2011-06-08 | 中国石油化工股份有限公司 | Low-oxygen processing device for laboratory polymer solution |
| CN203470018U (en) * | 2013-09-10 | 2014-03-12 | 浙江农林大学 | Device for metering amount of added liquid through nitrogen filling and oxygen dispensing |
| CN204017480U (en) * | 2014-08-18 | 2014-12-17 | 福建师范大学 | A kind of laboratory starvation suction filtration device |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201855700U (en) * | 2010-10-09 | 2011-06-08 | 中国石油化工股份有限公司 | Low-oxygen processing device for laboratory polymer solution |
| CN203470018U (en) * | 2013-09-10 | 2014-03-12 | 浙江农林大学 | Device for metering amount of added liquid through nitrogen filling and oxygen dispensing |
| CN204017480U (en) * | 2014-08-18 | 2014-12-17 | 福建师范大学 | A kind of laboratory starvation suction filtration device |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112108100A (en) * | 2020-10-23 | 2020-12-22 | 山东诺为制药流体系统有限公司 | Baffle box and reactor |
| CN115232713A (en) * | 2022-09-02 | 2022-10-25 | 安徽大学 | Portable laboratory simple and easy device of oxygen in getting rid of culture medium |
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| CN105148812B (en) | 2017-04-12 |
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