CN105124578A - Health-care food - Google Patents
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- CN105124578A CN105124578A CN201510558745.4A CN201510558745A CN105124578A CN 105124578 A CN105124578 A CN 105124578A CN 201510558745 A CN201510558745 A CN 201510558745A CN 105124578 A CN105124578 A CN 105124578A
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention discloses a health-care food. The health-care food contains the following raw materials of paecilomyces hepialid powder, glossy ganoderma, freeze-dried natto powder, poria cocos, astragalus membranaceus, radix achyranthis bidentatae, Chinese angelica, dendrobium candidum, American ginseng, radix salviae miltiorrhizae and pseudo-ginseng. According to the health-care food, the selected raw materials are scientific and reasonable in compounding ratio, foretaste tests on human bodies prove that the health-care food has favorable effects of improving immunity, strengthening constitutions and assisting in reducing blood lipid.
Description
Technical field
The present invention relates to a kind of health food, especially a kind of there is good raising immunity, build up health, the health food of auxiliary antilipemic effect.
Background technology
According to the World Health Organization's statistics display in recent years, the people in the whole world nearly more than 70% is in the third state and sub-health state, and is multiplely born in professional population, and thus inferior health is otherwise known as " new century is sick ".Data analysis according to " the large investigation of Chinese city health status " shows, " White Bone Demon " (white collar, backbone, elite) crowd's sub-health state ratio in China's main flow city reaches 76%, be in overwork state close to sixty percent, " Healthy People " ratio extremely low (less than 3%) truly.In the salt of the earth of 35 to 50 years old and middle booming income crowd, " biological age " overage trend was obviously accelerated, average more than " physiological age " about 10 years.
Summary of the invention
The invention provides a kind of health food, good raising immunity can be played, build up health, auxiliary antilipemic effect.
The present invention realizes with following technical scheme: health food of the present invention is made up of the common hybrid process of the raw material of following portions by weight: peacilomyce hepiahi bacterium powder 2-6 part, glossy ganoderma 1-3 part, freeze dry powder of fermented soybean 8-16 part, Poria cocos 0.2-0.5 part, Radix Astragali 0.4-1 part, root of bidentate achyranthes 0.3-0.6 part, Radix Angelicae Sinensis 1-3 part, dendrobium candidum 0.2-0.4 part, American Ginseng 3-8 part, red sage root 0.5-1 part, pseudo-ginseng 1-2 part.
Preparation method of the present invention, comprise the following steps: glossy ganoderma, Poria cocos, the Radix Astragali, the root of bidentate achyranthes, Radix Angelicae Sinensis, dendrobium candidum, American Ginseng, the red sage root, pseudo-ginseng are mixed by weight proportion, then conveniently water extraction mode extracts twice, after merging extracted twice liquid, concentrated spray is dry, mix with the peacilomyce hepiahi bacterium powder of formula ratio, freeze dry powder of fermented soybean again, add auxiliary material and can obtain granule, tablet, hard capsule, soft capsule through corresponding technique.
Peacilomyce hepiahi bacterium powder is the substitute of natural cordyceps in pharmacy industry and food industry.Be separated from natural cordyceps and obtain Chinese caterpillar fungus hypha, through fermented and cultured, the mycelial effect of gained is substantially identical with natural cordyceps, and effect is stronger.It is rich in adenosine, polysaccharide isoreactivity material, and not only rich content and ratio are suitable, effectively strengthen human body constitution, improve immunity function and anti-fatigue ability comprehensively.Peacilomyce hepiahi bacterium powder can impel the antibody-secreting amount of human body to increase, and can activate the immunocompetent cell of body, especially have obvious facilitation to lymphocyte transformation and abdominal cavity macrophage phagocytosis.
Glossy ganoderma, profile is umbrella, cap kidney shape, semicircle or subcircular, is the fructification of On Polyporaceae glossy ganoderma.There is invigorating qi for tranquilization, relieving cough and asthma effect, cough breathe heavily for dizzy egersis, palpitation, consumptive disease.
Freeze dry powder of fermented soybean contains Bacillus natto, natto polypeptide, natto polysaccharide, mucoitin, superoxide dismutase, glutathione, Nattokinase, pyridinedicarboxylic acid, lysozyme, high resiliency protease, lecithin, saponin, isoflavones, farnoquinone, vitamin E, B family vitamin, several mineral materials etc., has the physiological activator of more than 150 kinds.Can immune system be improved, improve the disease of immune system such as rheumatoid disease, lupus erythematosus, psoriasis; Impel cancer cell-apoptosis, improve polyp, hyperplasia, tumour, myomata, tumour etc.
Compendium of Material Medica: Poria cocos smell is light and ooze, and its property is up, born fluid, loosing the interspaces of skin and muscles, grows water source and declines, diuresis, therefore Zhang Jiegu calls its genus sun, floats and rises, saying its property also; Dong Yuan calls it for the YIN aspect of YANG, fall and under, Yan Qigong is also.
The Radix Astragali, nature and flavor: sweet, tepor.Gui Jing: return lung, spleen, liver, kidney channel.Its history in medicinal existing more than 2000 year so far, it has enhanced machine body immunity function, protects the liver, diuresis, anti-ageing, resisting stress, step-down and antibacterial action more widely.
The root of bidentate achyranthes, nature and flavor: bitter, sweet, sour are flat.Gui Jing: return liver, kidney channel.Effect: stimulate the menstrual flow by the stasis of blood, filling liver kidney, strengthening the bones and muscles, inducing diuresis for treating strangurtia, ensurings proper downward flow of the blood.Cure mainly: for through closing, dysmenorrhoea, soreness of waist and knee joint, muscles and bones is unable, stranguria, oedema, headache, dizzy, toothache, day sore, spit blood, bleeding from five sense organs or subcutaneous tissue.
Radix Angelicae Sinensis, function cures mainly: enrich blood; Invigorate blood circulation; Menstruction regulating and pain relieving; Moisturize laxation.The all cards of the main deficiency of blood; Irregular menstruation; Through closing; Dysmenorrhoea; Abdominal mass knot is poly-; Uterine bleeding; Asthenia cold abdominalgia; Impotence numbness; Numbness; Intestines are dry just difficult; Heavy after dysentery characterized by blood in the stool; Ulcer sores; Injury from falling down.
Dendrobium candidum, flavor efficacy: taste is sweet, cold nature.To promote the production of body fluid nourishing the stomach; Nourishing Yin and clearing heat; Moistening lung kidney-nourishing; The strong waist of improving eyesight.
American Ginseng, nature and flavor: cool in nature, sweet, the micro-hardship of taste.Function cures mainly: boosting qi and nourishing yin, clearing heat and promoting fluid.Lose for deficiency of vital energy the moon, interior heat, cough and breathe heavily phlegm blood, abnormal heat is tired of tired, quenches one's thirst, and the dry larynx of mouth is done.Benefit lung yin, the clear fire of deficiency type, promotes the production of body fluid to quench thirst.Control the deficiency syndrome of the lung to cough for a long time, lose blood, dry throat and mouth, abnormal heat is tired of tired.
The red sage root has promoting blood circulation, inducing meastruation to relieve menalgia, and clear away heart-fire relieving restlessness, and cool blood disappears effect of carbuncle.For chest impediment and cardialgia, gastral cavity abdomen hypochondriac pain, lump in the abdomen lump in the abdomen is gathered, hot numbness pain, dysphoria and insomnia, and irregular menstruation, dysmenorrhoea is through closing, and sore swells and ache.
Pseudo-ginseng, nature and flavor: sweet, micro-hardship, temperature.Gui Jing: return liver, stomach warp.Effect: loose stasis of blood hemostasis, detumescence ding-tong.Cure mainly: for spitting of blood, spit blood, bleeding from five sense organs or subcutaneous tissue, has blood in stool, uterine bleeding, traumatism and bleeding, chest ventral spine pain, tumbling and swelling.
The invention has the beneficial effects as follows: the present invention utilizes pure natural Chinese herbal medicine and raw-food material to be prepared into health food, this formula studies science in strict accordance with theory of traditional Chinese medical science and modern health to draft, whole reasonable recipe, rigorous, the health food of multiple formulation can be prepared into, the cause of disease of existing inferior health has been decided from human organism's Interior Solutions, fundamentally solve inferior health problem, instead of simply take stopgap measures.
The present invention selects peacilomyce hepiahi bacterium powder to replace the Cordyceps sinensis of traditional Chinese medicine, replaces expensive natural product with artificial fermentate, relaxes natural cs medicine source few, the contradiction that supply falls short of demand.The raw material that the present invention chooses is easy to get, and preparation technology is relatively simple, and cost can be controlled, and is easy to suitability for industrialized production.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described further.
Embodiment 1
A kind of health food, this health food is prepared into hard shell capsules, and its component and parts by weight are: 4 parts, peacilomyce hepiahi bacterium powder, glossy ganoderma 1.5 parts, freeze dry powder of fermented soybean 12 parts, 0.26 part, Poria cocos, the Radix Astragali 0.7 part, the root of bidentate achyranthes 0.38 part, Radix Angelicae Sinensis 1.5 parts, dendrobium candidum 0.33 part, American Ginseng 6 parts, the red sage root 0.8 part, pseudo-ginseng 1.5 parts.Glossy ganoderma, Poria cocos, the Radix Astragali, the root of bidentate achyranthes, Radix Angelicae Sinensis, dendrobium candidum, American Ginseng, the red sage root, pseudo-ginseng are mixed by weight proportion, then conveniently water extraction mode extracts twice, after merging extracted twice liquid, concentrated spray is dry, mix with the peacilomyce hepiahi bacterium powder of formula ratio, freeze dry powder of fermented soybean again, be filled in capsule shells by hard shell capsules automatic filling equipment, make hard capsule.
According to Example formulations, 1000 people try out, wherein 971 people think the present invention in raising immunity, build up health, there is significant effect in reducing blood lipid, total effective rate is 97.1%.
Embodiment 2
A kind of health food, this health food is prepared into tablet, and its component and parts by weight are: 5.6 parts, peacilomyce hepiahi bacterium powder, glossy ganoderma 2.1 parts, freeze dry powder of fermented soybean 15 parts, 0.36 part, Poria cocos, the Radix Astragali 0.78 part, the root of bidentate achyranthes 0.45 part, Radix Angelicae Sinensis 1.5 parts, dendrobium candidum 0.28 part, American Ginseng 6 parts, the red sage root 0.6 part, pseudo-ginseng 1.8 parts.Glossy ganoderma, Poria cocos, the Radix Astragali, the root of bidentate achyranthes, Radix Angelicae Sinensis, dendrobium candidum, American Ginseng, the red sage root, pseudo-ginseng are mixed by weight proportion, then conveniently water extraction mode extracts twice, after merging extracted twice liquid, concentrated spray is dry, mix with the peacilomyce hepiahi bacterium powder of formula ratio, freeze dry powder of fermented soybean again, add a certain amount of sodium carboxymethyl starch, after granulation, be pressed into plain sheet, dressing, obtains tablet.
According to Example formulations, 1000 people try out, and wherein 969 people think that the present invention has significant effect in improving immunity, building up health, and total effective rate is 96.9%.
Function test
1 materials and methods
1.1 sample copy invention products, specification 0.8g/ sheet × 40 slice/bottle, are provided by the present inventor, sample morphology be yellowish-brown to sepia tablet, sealing is put shady and cool dry place and is preserved.Sample human body RD is 3.2g/ (people d).
200 Healthy female mouse that 1.2 animal origins and point group selection are bred purchased from Shanghai western pul-Bi Kai animal used as test Co., Ltd, body weight is 19.0 ~ 21.9g.Experimental animal room temperature is 21 ~ 25 DEG C, relative humidity is 45% ~ 70%.Experimental animal is divided into 5 large group at random by body weight, often organizes 40 greatly and is divided into 4 dosage groups, each dosage group 10 mouse, and wherein first treated animal measures the mouse spleen lymphocyte conversion of ConA induction and utilizes lactic dehydrogenase enzyme process mensuration NK cytoactive; Second largest treated animal utilizes auricle edema method to carry out the delayed allergy of DNFB inducing mouse; The third-largest treated animal carries out humoral immune function detection (antibody-producting cell detects and serum hemolysin measures); The fourth-largest treated animal carries out the carbonic clearance test of monocytes/macrophages function; The fifth-largest treated animal carry out monocytes/macrophages function utilize half intracorporal method carry out peritoneal macrophage engulf chicken red blood cell test.
The human body RD that 1.3 dosage choice and tested material give mode given the test agent is 3.2 (people d) (with 60kg batheroom scale), if be equivalent to 3 dosage groups of 5 times of given the test agent human body recommended intake, 10 times, 30 times respectively, namely 0.27,0.53,1.60g/ (kgbwd).Control group is separately established to replace tested material with sterilized water, i.e. 0g/ (kgbwd).Adopt sterilized water preparation given the test agent, by high, medium and low dosage respectively compound concentration be 160,53,27mg/ml, per os gives the tested material of animal subject corresponding dosage once a day, and mouse stomach amount is 0.1ml/ (10gbw).Successive administration detects various functions index after one month.
1.4 pertinent instruments and reagent
1.4.1 instrument.Card punch, multi-functional ELIASA, CO2gas incubator, SG-603 Biohazard Safety Equipment, T1000 type electronic balance, JA2003 type electronic balance, JJ-100 type electronic balance.
1.4.2 reagent.GPS, india ink, isopropyl alcohol, Dou Shi reagent, SA buffer solution, YAC-1 cell, LDH matrix liquid, DNFB, SRBC, RPMI1640, Co-nA, MTT.
1.5 data statistics SPSS10.0 softwares carry out homogeneity test of variance to each test initial data, meet the data information that variance requires together, in use one-way analysis of variance method, between multiple test group and a control group, the comparative approach between two of mean carries out statistical disposition; Suitable variable transitions is carried out to the data information of Non-Gaussian Distribution or heterogeneity of variance, after meeting normal state or variance and requiring together, carries out statistical disposition by the data of conversion gained.
1.6 results judge that in wantonly 2, result is positive in cellular immune function (the mouse spleen lymphocyte conversion of ConA induction, DNFB inducing mouse DTH), humoral immune function (antibody-producting cell detection, serum hemolysin measure), monocytes/macrophages function (mouse carbonic clearance, Turnover of Mouse Peritoneal Macrophages engulf chicken red blood cell), NK cytoactive 4, can judge that this given the test agent has develop immunitypty effect.2 result of the tests wherein in cellular immune function assay, humoral immune function mensuration, each project of monocytes/macrophages functional examination are the positive, or 2 dosage group results of any one test are positive, can judge that this functional examination result is positive.More than one dosage group result of NK cytoactive detection test is positive, can judge that NK cytoactive result is positive.
2 results and analysis
2.1 cellular immune function tests
2.1.1 product of the present invention is on the impact of the mouse spleen lymphocyte conversion that ConA induces.After per os gives the product 30d of the present invention of mouse various dose, carry out the mouse spleen lymphocyte conversion test (mtt assay) of ConA induction, calculate the difference (add ConA hole and do not add ConA hole) of absorbance, and homogeneity test of variance is carried out to it, meet homogeneity of variance requirement, carry out statistical disposition with the comparative approach between two of mean between test group multiple in one-way analysis of variance method and a control group.1.60 (kgbwd) organize the difference (add ConA hole with do not add ConA hole) of absorbance, and, higher than 0g/ (kgbwd) group, difference has statistical significance (P<0.05).
2.1.2 product of the present invention is on the impact of DNFB inducing mouse DTH.Per os gave the product of the present invention of mouse various dose after one month, carry out DNFB inducing mouse DTH by ear swelling method to test, calculating auricular concha increases weight, and carry out homogeneity test of variance, meet after homogeneity of variance requires and carry out statistical disposition with the comparative approach between two of mean between test group multiple in one-way analysis of variance method and a control group.0.53,1.60 (kgbwd) organize auricular concha weightening finish higher than 0g/ (kgbwd) group, and difference has statistical significance (P<0.05).
2.2 ion vitro immunization function tests
2.2.1 product of the present invention is on the impact of mouse antibodies cellulation.After per os gives the product 30d of the present invention of mouse various dose, improve slide method with Jerne and carry out the test of mouse antibodies cellulation, calculate hemolysis plaque number, and carry out homogeneity test of variance, meet after homogeneity of variance requires and carry out statistical disposition with the comparative approach between two of mean between test group multiple in one-way analysis of variance method and a control group.1.60g/ (kgbwd) organizes hemolysis plaque number higher than 0g/ (kgbwd) group, and difference has statistical significance (P<0.05).
2.2.2 product of the present invention is on the impact of mice serum HD50 value.Per os gave the product of the present invention of mouse various dose after one month, measured the half hemolytic dose of mouse, and carried out homogeneity test of variance, do not meet homogeneity of variance requirement, carry out statistical disposition with rank test by HD50 value method.0.27,0.53,1.60g/ (kgbwd) organizes mice serum HD50 value (HC5.) compare with 0g/ (kgbwd) group, no significant difference (P>0.05).
2.3 monocytes/macrophages function tests
2.3.1 product of the present invention is on the impact of mouse carbonic clearance ability.Per os gave the product of the present invention of mouse various dose after one month, carry out the test of mouse carbonic clearance, calculate phagocytic index a, and carry out homogeneity test of variance, meet homogeneity of variance requirement, carry out statistical disposition with the comparative approach between two of mean between test group multiple in one-way analysis of variance method and a control group.1.60g/ (kgbwd) organizes mouse phagocytic index higher than 0g/ (kgbwd) group, and difference has statistical significance (P<0.05).
2.3.2 product of the present invention engulfs the impact of chicken red blood cell on Turnover of Mouse Peritoneal Macrophages.After per os gives the product 30d of the present invention of mouse various dose, carry out Turnover of Mouse Peritoneal Macrophages with half intracorporal method and engulf chicken red blood cell test, calculate phagocytic index and phagocytic percentage, and by phagocytic percentage through sin
-1p
1/2(P is phagocytic percentage, represents decimally) carries out homogeneity test of variance after transforming, and after meeting homogeneity of variance requirement, carries out statistical disposition with the comparative approach between two of mean between test group multiple in one-way analysis of variance method and a control group.1.60g/ (kgbwd) organizes phagocytic percentage and phagocytic index higher than 0g/ (kgbwd) group, and difference has statistical significance (P<0.05).
2.4NK cytoactive detection per os carries out NK cells in mice determination of activity, by it through sin by determination of lactate dehydrogenase method after giving the product 30d of the present invention of mouse various dose
-1p
1/2(P is NK cytoactive, represents decimally) carries out homogeneity test of variance after transforming, and meets homogeneity of variance requirement, carries out statistical disposition with the comparative approach between two of mean between test group multiple in one-way analysis of variance method and a control group.0.27,0.53,1.60 (kgbwd) organize NK cytoactive and 0 (kgbwd) group and compare, no significant difference (P>0.05).
3 brief summaries
Product of the present invention with 0.27,0.53,1.60g/ (kgbwd) gives sample 30d continuously, by " health food inspection and assessment technical specification " requirement, respectively the mouse of various dose group is carried out to the mensuration of cellular immune function, humoral immune function, monocytes/macrophages function, NK cytoactive.Found that, the cellular immune function test of product develop immunitypty function of the present invention is humoral immune function test that is positive, product develop immunitypty function of the present invention is that monocytes/macrophages function test that is negative, product develop immunitypty function of the present invention is the positive, the NK cytoactive detection test of product develop immunitypty function of the present invention is feminine gender.
Result according to the develop immunitypty function test of " health food inspection and assessment technical specification " judges, in cellular immune function (the mouse spleen lymphocyte conversion of ConA induction, DNFB inducing mouse DTH), humoral immune function (antibody-producting cell detection, serum hemolysin measure), monocytes/macrophages function (mouse carbonic clearance, Turnover of Mouse Peritoneal Macrophages engulf chicken red blood cell), NK cytoactive 4, in wantonly 2, result is positive, can judge that this given the test agent has develop immunitypty effect.Under this experimental condition, product of the present invention has develop immunitypty function.
Above to invention has been detailed introduction, the explanation of above embodiment just understands the present invention for helping.Those of ordinary skill in the art should be appreciated that to change technical scheme of the present invention, retouch or be equal to and replaces, and does not depart from the spirit and scope of technical solution of the present invention, and it all should belong in the middle of claims of the present invention.
Claims (2)
1. a health food, is characterized in that it is made up of the common hybrid process of the raw material of following portions by weight: peacilomyce hepiahi bacterium powder 2-6 part, glossy ganoderma 1-3 part, freeze dry powder of fermented soybean 8-16 part, Poria cocos 0.2-0.5 part, Radix Astragali 0.4-1 part, root of bidentate achyranthes 0.3-0.6 part, Radix Angelicae Sinensis 1-3 part, dendrobium candidum 0.2-0.4 part, American Ginseng 3-8 part, red sage root 0.5-1 part, pseudo-ginseng 1-2 part.
2. the preparation method of a health food, comprise the following steps: glossy ganoderma, Poria cocos, the Radix Astragali, the root of bidentate achyranthes, Radix Angelicae Sinensis, dendrobium candidum, American Ginseng, the red sage root, pseudo-ginseng are mixed by weight proportion, then conveniently water extraction mode extracts twice, after merging extracted twice liquid, concentrated spray is dry, mix with the peacilomyce hepiahi bacterium powder of formula ratio, freeze dry powder of fermented soybean again, add auxiliary material and obtain granule, tablet, hard capsule, soft capsule through corresponding technique.
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| CN110663948A (en) * | 2019-11-20 | 2020-01-10 | 江西普正制药股份有限公司 | Health product with immunity enhancing effect and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110663948A (en) * | 2019-11-20 | 2020-01-10 | 江西普正制药股份有限公司 | Health product with immunity enhancing effect and preparation method thereof |
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Application publication date: 20151209 |