CN105079717A - Pharmaceutical preparation for treating depression - Google Patents

Abstract

The invention belongs to the field of a traditional Chinese medicinal preparation, and in particular provides a pharmaceutical preparation for treating depression, wherein the pharmaceutical preparation is prepared from the following raw materials: 24 parts of herba violae, 25 parts of desmodium caudatum, 18 parts of periploca calophylla, 25 parts of cortex cereis, 15 parts of microsorium fortunei ching, 25 parts of selfheal, 28 parts of curcuma aromatica, 15 parts of bamboo shavings, 15 parts of tuber fleeceflower stem, 20 parts of chrysanthemum, 25 parts of rhizoma alismatis, 20 parts of astragalus membranaceus, 25 parts of angelica, 20 parts of ligusticum wallichii, 15 parts of safflower, 15 parts of fructus aurantii, 15 parts of folium artemisiae argyi, 25 parts of common dayflower herb, 15 parts of fructus citrus sarcodactylis and 5 parts of liquorice. The pharmaceutical preparation disclosed by the invention can be used for treating depression.

Description

A kind of pharmaceutical preparation being used for the treatment of depression

Technical field

The present invention relates to technical field of traditional Chinese medicine preparation, be specifically related to a kind of pharmaceutical preparation being used for the treatment of depression and its preparation method and application.

Background technology

Depression is also known as depressive disorder, low for main clinical characteristics with remarkable and lasting mental state, is the main Types of mood disorders.Clinical visible mental state is low unbecoming with its situation, and the downhearted of emotion can from depressed to extremely grieved, and depression of feeling oneself inferior is even pessimistic and worldweary, can have suicidal attempt or behavior; Even occur numb; Some cases have obvious anxiety and mobility intense; The psychotic symptoms such as hallucination, vain hope can be there is in severe patient.Even each outbreak continues at least 2 weeks more than, elder's several years, majority of cases has the tendency of recurrent exerbation, and each outbreak great majority can be alleviated, and part can have residual symptoms or transfer to chronic.For this reason, the needs that the medicine developing more Cure of depressions safely and effectively meets clinical treatment are bursting to.

Summary of the invention

In order to solve the problem, the object of the present invention is to provide a kind of can the Chinese medicine preparation of Cure of depression disease.In order to reach this object, adopt following technical scheme:

Technical scheme: a kind of pharmaceutical preparation being used for the treatment of depression, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: little Herba Polygalae Telephioidis 24 parts, Desmodium caudatum (Thunb.) DC. 25 parts, blue or green mabi 18 parts, Cortex cercis chinensis 25 parts, Microsorium fortunei (Moore) Ching [Drynaria fortunei Moore 15 parts, Spica Prunellae 25 parts, Radix Curcumae 28 parts, Caulis Bambusae In Taenia 15 parts, Caulis Polygoni Multiflori 15 parts, Flos Chrysanthemi 20 parts, Rhizoma Alismatis 25 parts, the Radix Astragali 20 parts, Radix Angelicae Sinensis 25 parts, Rhizoma Chuanxiong 20 parts, 15 parts, Flos Carthami, Fructus Aurantii 15 parts, Folium Artemisiae Argyi 15 parts, Herba Commelinae 25 parts, Fructus Citri Sarcodactylis 15 parts, 5 parts, Radix Glycyrrhizae.

The described pharmaceutical preparation being used for the treatment of depression, dosage form is pharmaceutically acceptable granule, tablet, capsule.

The described pharmaceutical preparation being used for the treatment of depression, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.

The described application of pharmaceutical preparation in preparation medicament for treatment of depression being used for the treatment of depression.

Little Herba Polygalae Telephioidis is Polygalaceae polygala polygala arvensis PolygalaarvensisWilld., with all herbal medicine.Autumn gathers, and dries.Dissipating blood stasis stops blooding, preventing phlegm from forming and stopping coughing, removing toxic substances and promoting subsidence of swelling.For chest pain of coughing, pulmonary tuberculosis, hemoptysis, hematuria, has blood in stool, menoxenia, traumatic injury, poliomyelitis sequela, hepatitis, venom.

Desmodium caudatum (Thunb.) DC. is pulse family beggar-ticks plant Desmodium caudatum (Thunb.) DC. Desmodiumcaudatum (Thunb.) DC., is used as medicine with root or Herb.Summer, autumn gather, and clean and dry, the using fresh herb four seasons can adopt.Heat-clearing and toxic substances removing, expelling wind and removing dampness.For cat fever, gastroenteritis, dysentery, infantile malnutrition, rheumatic arthritis; Venom is controlled in external, carbuncle furuncle furuncle, mastitis.The present invention is used as medicine with root.

Blue or green mabi is asclepiadaceae Periploca Plants U.S. leaf P. sepium Bunge Periplocacalophylla (Wight) Falc., is used as medicine with stem, expelling wind and cold, cold expelling of invigorating blood circulation.For rheumatic numbness, lumbago, traumatic injury, menoxenia.

Cortex cercis chinensis is the dry bark of leguminous plant cercis, Classification system CercischinensisBunge, energy promoting blood circulation to restore menstrual flow, reducing swelling and alleviating pain, removing toxic substances.For menoxenia, dysmenorrhea, amenorrhea is suffered from abdominal pain, rheumatic arthritis, traumatic injury, laryngopharynx swelling and pain; Swelling and pain of hemorrhoid is controlled in external, worm venom.

Microsorium fortunei (Moore) Ching [Drynaria fortunei Moore is Polypodiaceae subfam. Microsoroideae Cyclosorus plant south of the River Microsorium Link Microsoriumfortune (Moore) Ching, is used as medicine with herb and root stock.The four seasons can adopt, and clean, using fresh herb or dry.Clearing away heat-damp and promoting diuresis, cooling blood for hemostasis, reducing swelling and alleviating pain.For jaundice, dysentery, urinary tract infection, tuberculous lymphadenitis, leucorrhea, rheumatic arthritis, hemoptysis, spits blood, has blood in stool, epistaxis; Traumatic injury is controlled in external, fracture, venom, furuncle swelling toxin.The present invention is with all herbal medicine.All the other Chinese medicines are pharmacopeia kind.

Beneficial effect: the traditional Chinese medical science is thought, mostly depression is because feelings will hindered, depression of liver-QI causes caused by the five internal organs mechanism of qi discord gradually, but mainly liver, spleen, the heart three is dirty gets involved and disorder of QI and blood forms, the little Herba Polygalae Telephioidis of the present invention, Desmodium caudatum (Thunb.) DC., blue or green Serpentis rattan, Cortex cercis chinensis, Microsorium fortunei (Moore) Ching [Drynaria fortunei Moore, Spica Prunellae, Radix Curcumae, Caulis Bambusae In Taenia, Caulis Polygoni Multiflori, Flos Chrysanthemi heat-clearing and toxic substances removing, depressed liver-energy dispersing and QI regulating is monarch drug, Rhizoma Alismatis, the Radix Astragali, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Flos Carthami, Fructus Aurantii, Folium Artemisiae Argyi, Herba Commelinae, Fructus Citri Sarcodactylis blood circulation promoting and blood stasis dispelling, wind-dispelling heat-dissipating, dispersing the stagnated live-QI to relieve the stagnation of QI is ministerial drug, Radix Glycyrrhizae is adjuvant, the mutual compatibility of full side, Cure of depression successful.

Detailed description of the invention

Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.

1, the preparation of granule embodiment: get little Herba Polygalae Telephioidis 24g, Desmodium caudatum (Thunb.) DC. 25g, blue or green mabi 18g, Cortex cercis chinensis 25g, Microsorium fortunei (Moore) Ching [Drynaria fortunei Moore 15g, Spica Prunellae 25g, Radix Curcumae 28g, Caulis Bambusae In Taenia 15g, Caulis Polygoni Multiflori 15g, Flos Chrysanthemi 20g, Rhizoma Alismatis 25g, Radix Astragali 20g, Radix Angelicae Sinensis 25g, Rhizoma Chuanxiong 20g, Flos Carthami 15g, Fructus Aurantii 15g, Folium Artemisiae Argyi 15g, Herba Commelinae 25g, Fructus Citri Sarcodactylis 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, and atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch 50g, granulate, make granule.

2, the preparation of Tablets Example: get little Herba Polygalae Telephioidis 24g, Desmodium caudatum (Thunb.) DC. 25g, blue or green mabi 18g, Cortex cercis chinensis 25g, Microsorium fortunei (Moore) Ching [Drynaria fortunei Moore 15g, Spica Prunellae 25g, Radix Curcumae 28g, Caulis Bambusae In Taenia 15g, Caulis Polygoni Multiflori 15g, Flos Chrysanthemi 20g, Rhizoma Alismatis 25g, Radix Astragali 20g, Radix Angelicae Sinensis 25g, Rhizoma Chuanxiong 20g, Flos Carthami 15g, Fructus Aurantii 15g, Folium Artemisiae Argyi 15g, Herba Commelinae 25g, Fructus Citri Sarcodactylis 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, adds dextrin 50g, granulates, tabletting, makes tablet.

3, the preparation of capsule embodiment: get little Herba Polygalae Telephioidis 24g, Desmodium caudatum (Thunb.) DC. 25g, blue or green mabi 18g, Cortex cercis chinensis 25g, Microsorium fortunei (Moore) Ching [Drynaria fortunei Moore 15g, Spica Prunellae 25g, Radix Curcumae 28g, Caulis Bambusae In Taenia 15g, Caulis Polygoni Multiflori 15g, Flos Chrysanthemi 20g, Rhizoma Alismatis 25g, Radix Astragali 20g, Radix Angelicae Sinensis 25g, Rhizoma Chuanxiong 20g, Flos Carthami 15g, Fructus Aurantii 15g, Folium Artemisiae Argyi 15g, Herba Commelinae 25g, Fructus Citri Sarcodactylis 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, adds starch 50g, granulates, fill, makes capsule.

4, pharmaceutical preparation Cure of depression of the present invention clinical research

4.1 general data: this pharmaceutical preparation is applied to clinical observation depression case 50 example, 45 ~ 64 years old age.The shortest person of the course of disease 4 months, most elder reaches 3 years.

4.2 diagnostic criterias: the diagnostic criteria of all cases meet " Chinese Spirit Obstacles classification and diagnostic criteria " (CCMD-3) depression: (1) is low based on mental state, and has following 4 at least: 1. hebetude, without happy sense; 2. energy goes down or tired sense; 3. psychomotor activity is sluggish or intense; 4. self evaluation too low, self-accusation or have feeling of guilt; 5. association difficulty or conscious elaborative faculty decline; 6. repeatedly there is the thought of wanting to die or have suicide, autolesionism; 7. sleep disorder, as insomnia, early awakening or hypersomnia; 8. appetite reduction or body weight obviously alleviate; 9. hyposexuality.(2) order of severity standard (having one of following situation at least): 1. social function is impaired; 2. cause suffering or adverse consequences to me.(3) course of disease standard: symptom at least continues 2 weeks; (4) compliance is good, agrees to the person of following up a case by regular visits to.

4.3 test methods: prepare clinical sample by above-mentioned process for producing granula, specification is 10 grams every bag, within five days, is a course for the treatment of, one day three bags, take point early, middle and late three half an hour ante cibum.Period in a medicine is avoided eating anything raw or cold, pungent, stimulate and rotten thing.Blank group oral placebo granule five days is a course for the treatment of, one day three bags, point early, middle and late three half an hour ante cibum take.

4.4 criterions of therapeutical effect: do 17 Hamilton depressive scales (HAMD) at pre-treatment and after treatment respectively, using front and back deduction as the observation index of curative effect, deduction rate >=80% is recovery from illness, deduction rate is effective between 50-79%, deduction rate is effectively at 25-49%, and deduction rate is less than 25% for invalid.

4.5 therapeutic effect: in table 1.

Table 1 liang group comparitive study

Group	n	Recovery from illness	Effective	Effectively	Invalid	Total effective rate (%)
							Treatment group	25	4	3	15	3	88
Blank group	25	1	1	0	23	8

Visible, the medicine that the present invention obtains can safe and effective Cure of depression, and has no side effect.

Claims (4)

1. one kind is used for the treatment of the pharmaceutical preparation of depression, it is characterized in that, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: little Herba Polygalae Telephioidis 24 parts, Desmodium caudatum (Thunb.) DC. 25 parts, blue or green mabi 18 parts, Cortex cercis chinensis 25 parts, Microsorium fortunei (Moore) Ching [Drynaria fortunei Moore 15 parts, Spica Prunellae 25 parts, Radix Curcumae 28 parts, Caulis Bambusae In Taenia 15 parts, Caulis Polygoni Multiflori 15 parts, Flos Chrysanthemi 20 parts, Rhizoma Alismatis 25 parts, the Radix Astragali 20 parts, Radix Angelicae Sinensis 25 parts, Rhizoma Chuanxiong 20 parts, 15 parts, Flos Carthami, Fructus Aurantii 15 parts, Folium Artemisiae Argyi 15 parts, Herba Commelinae 25 parts, Fructus Citri Sarcodactylis 15 parts, 5 parts, Radix Glycyrrhizae.

2. be used for the treatment of the pharmaceutical preparation of depression as claimed in claim 1, it is characterized in that, dosage form is pharmaceutically acceptable granule, tablet, capsule.

3. be used for the treatment of the pharmaceutical preparation of depression as claimed in claim 1, it is characterized in that, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.

4. be used for the treatment of the application of pharmaceutical preparation in medicament for treatment of depression of depression according to claim 1.