CN105031331B - A kind of navel patch and preparation method thereof for treating dysmenorrhea - Google Patents
A kind of navel patch and preparation method thereof for treating dysmenorrhea Download PDFInfo
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Abstract
The invention belongs to technical field of traditional Chinese medicine preparation, in particular to a kind of navel patch and preparation method thereof for treating dysmenorrhea.The navel patch of the treatment dysmenorrhea mainly includes Radix Rehmanniae, radix rehmanniae preparata, pulp of dogwood fruit, the root bark of tree peony, rhizoma alismatis, Poria cocos, cortex cinnamomi, radix aconiti lateralis preparata, Chinese yam, radix achyranthis bidentatae, corydalis tuber, the root of three-nerved spicebush, rice shell, Rhizoma Chuanxiong, safflower, borneol isoreactivity ingredient and auxiliary material, it is effective by each ingredient, reasonable compatibility, mutually collaboration, it collectively promotes, drug effect is obtained significantly and specifically for the patch of dysmenorrhea, without any hormone medicine, curative effect is good, it does not have any side-effects, sequelae shape is uneasy to recur, cure rate is high, solves the pain of menalgia patient, relieve the various discomforts of dysmenorrhea bring in Working Life study.
Description
(1) technical field
The invention belongs to technical field of traditional Chinese medicine preparation, in particular to a kind of navel patch for treating dysmenorrhea and its preparation side
Method.
(2) background technique
Dysmenorrhea is one of most common gynaecology's symptom, refers to before and after passing through or lower abdominal pain, falling inflation occurs in the menstrual period, with
The soreness of waist or other uncomfortable, serious symptom influence quality of life persons.Dysmenorrhea is divided into primary dysmenorrhea and secondary two class, primary pain
Through referring to dysmenorrhea of the reproductive organs without organic disease, 90% or more dysmenorrhea is accounted for；Acquired dysmenorrhea refers to is drawn by pelvic cavity organic disease
The dysmenorrhea risen.Primary treatment drug is the common drug of prostaglandin synthase inhibitor at present, such as brufen, Ketoprofen, first
Clofenamic acids, Diclofenac etc..Chinese medicine treatment is mostly oral Chinese herbal medicine, Chinese patent drug, and type is more, and effect is not significant, late result
It is bad.
(3) summary of the invention
In order to make up for the deficiencies of the prior art, simple, with strong points, significant in efficacy and nothing is prepared the present invention provides a kind of
Navel patch for the treatment of dysmenorrhea of toxic side effect and preparation method thereof.The relieving spasm and pain of navel patch energy, the anti-inflammatory of the treatment dysmenorrhea,
With good therapeutic effect, any hormone medicine is free of, curative effect is good, does not have any side-effects, sequelae shape is not easy again
Hair, cure rate is high, solves the pain of menalgia patient, relieves the various discomforts of dysmenorrhea bring in Working Life study.
The present invention is achieved through the following technical solutions:
A kind of navel patch for treating dysmenorrhea, active constituent are prepared from the following raw materials in parts by weight:
4-8 parts of Radix Rehmanniae, 4-10 parts of radix rehmanniae preparata, 4-10 parts of pulp of dogwood fruit, 4-12 parts of the root bark of tree peony, 4-12 parts of rhizoma alismatis, 4-12 parts of Poria cocos, meat
Osmanthus 1-5 parts, 1-5 parts of radix aconiti lateralis preparata, 5-15 parts of Chinese yam, 4-12 parts of radix achyranthis bidentatae, 4-12 parts of corydalis tuber, 4-12 parts of the root of three-nerved spicebush, 1-6 parts of rice shell, river
2-10 parts of rhizome of chuanxiong, 2-10 parts of safflower, 0.5-2 parts of borneol；
It further include the auxiliary material of following parts by weight: 15-25 parts of glycerol, 20-40 parts of vaseline, 20-40 parts of lanolin, azone
5-15 parts, 5-15 parts of olive oil.
The navel patch of the treatment dysmenorrhea, preferred each active constituent are prepared from the following raw materials in parts by weight:
6 parts of Radix Rehmanniae, 6 parts of radix rehmanniae preparata, 8 parts of pulp of dogwood fruit, 8 parts of the root bark of tree peony, 8 parts of rhizoma alismatis, 8 parts of Poria cocos, 3 parts of cortex cinnamomi, 3 parts of radix aconiti lateralis preparata,
9 parts of Chinese yam, 8 parts of radix achyranthis bidentatae, 8 parts of corydalis tuber, 4 parts of 8 part, meter shell of the root of three-nerved spicebush, 6 parts of Rhizoma Chuanxiong, 6 parts of safflower, 1 part of borneol；
It further include the auxiliary material of following parts by weight: 20 parts of glycerol, 30 parts of vaseline, 30 parts of lanolin, 10 parts of olive oil, nitrogen
10 parts of ketone.
The preparation method of the navel patch of the treatment dysmenorrhea, includes the following steps:
A, Radix Rehmanniae, radix rehmanniae preparata, pulp of dogwood fruit, the root bark of tree peony, rhizoma alismatis, Poria cocos, cortex cinnamomi, the radix aconiti lateralis preparata, Chinese yam, ox of above-mentioned parts by weight are taken
Knee, corydalis tuber, the root of three-nerved spicebush, rice shell, Rhizoma Chuanxiong, safflower mixing, machinery are smashed into 10-20 mesh grade micro mist；
B, the step a micro mist crushed is placed in percolator, is continuously added 75% ethanol solution and carries out diacolation, collects and leach
Micro mist after liquid and diacolation, it is spare；The weight for the 75% total ethanol solution being added is 4-8 times of micropowder weight；
C, the micro mist after step b diacolation is taken out into drying, continues to be crushed to 200-400 mesh or nanoscale fine powder；
D, the leachate of step b is concentrated to give concentrate and is concentrated under reduced pressure into no ethanol flavor, recycled ethyl alcohol, obtain concentrate；So
It mixes and stirs evenly with the fine powder of step c afterwards；
E, take the auxiliary material of above-mentioned parts by weight: glycerol, vaseline, lanolin, azone and olive oil are mixed and are stirred evenly；
F, the borneol that the mixed material of step d and step e are mixed and added into above-mentioned parts by weight is placed in 18000- together
In the vortex mixer of 20000rmp/min mix be in ointment shape, weighing be shaped as pellet, be made patch to get.
The present invention treats the usage and dosage of the navel patch of dysmenorrhea: this navel patch alignment navel being attached, is used after sticking
Medicine person is comfortable on.Patient, which can be expert at during premenstrual 2-3 days or menstrual period, to be used, and general patch can be alleviated significantly simultaneously after 2-3 days
Eliminate symptom.Every patch can be used 24 hours.
The pharmaceutical characteristic of each active constituent of the present invention is as follows:
Radix Rehmanniae: it is sweet in flavor, it trembles with fear.Existing anastalsis, and have blood coagulation resisting function.It cures mainly folding to fall, exhausted muscle, in wound, by blood-arthralgia, fill out
Marrow, long muscle.
Radix rehmanniae preparata: sweet, tepor.Return liver and kidney channel.It enriches blood yin-nourishing, life essence-filling, marrow-benefitting.
Pulp of dogwood fruit: tonifying the liver and kidney, arresting seminal emission hidroschesis: the soreness of waist for kidney deficiency and liver passes out semen, has a dizzy spell, menorrhalgia and
The diseases such as frequent micturition, spontaneous perspiration.Spermatorrhea is controlled often with the fruit of Cherokee rose, the fruit of glossy privet；It controls spontaneous perspiration due to yang insufficiency and often matches Schisandra chinensis.
The root bark of tree peony: clearing heat and cooling blood；Promoting blood circulation to remove blood stasis.Warm heat disease heat invading xuefen；Macular eruption；Hematemesis；Germ later period heat volt brimful of tears
Yin distribution heat；Deficiency of Yin osteopyrexia and fever；Amenorrhea due to stagnation of blood；Dysmenorrhea；Carbuncle sore tumefacting virus；The pain of injury caused by falling and tumbling；Beriberoid pyretic arthralgia.
Rhizoma alismatis: sweet, light, cold.Return kidney, bladder meridian.Effect: controlling difficult urination, edema swelling, oliguria of having loose bowels, phlegmatic vertigo,
Puckery pain of heat gonorrhea, hyperlipidemia.
Poria cocos: slightly sweet flavor is flat, enters the heart, lung, the spleen channel.Effect: treatment edema and little urine, phlegm retention anti-dazzle nervous, spleen eating less, loose stool is let out
It rushes down, confused and worried, insomnia of palpitating with fear, it can strengthening the spleen and stomach, antitoxic heart-soothing and sedative.
Cortex cinnamomi: impotence palace cold, waist and knee crymodynia, kidney deficiency characterized by dyspnea, deficient yang with upper manifestation, dizziness hot eyes, trusted subordinate's crymodynia, cold of insufficiency type vomiting and diarrhea,
Cold hernia stomachache, dysmenorrhea menostasis.
Radix aconiti lateralis preparata: recuperating depleted yang, mends fire supporing yang, by wind-cold damp pathogen.It collapses for yang depletion, cold weak pulse of limb, impotence, palace cold,
Trusted subordinate's crymodynia, cold of insufficiency type vomiting and diarrhea, cold sensation of the genitalia oedema, deficiency of yang diseases caused by external factors, numbness and ache of cold dampness.
Chinese yam: weakness is controlled, general debility is treated, decaptitating seborrheic dematitis, stops pain in the loins, relieving restlessness heat, bushing unsaturated vapor, reaches the heart
Hole, more account, kidney-nourishing gas, strengthening the spleen and stomach, antidiarrheal dysentery, profit fur, it is raw to smash that patch swells, hard poison be controlled.
Radix achyranthis bidentatae: dispelling stasis of blood and stimulating the menstrual flow, nourishing liver and kidney, strengthening the bones and muscles, inducing diuresis for treating strangurtia are ensuringd proper downward flow of the blood.
Corydalis tuber: there are promoting blood circulation to remove blood stasis, regulating qi-flowing for relieving pain.
The root of three-nerved spicebush: promoting qi circulation and relieving pain, warming kidney for dispelling cold.
Rice shell: astringing lung-QI, puckery intestines, analgesic.
Rhizoma Chuanxiong: pungent scattered temperature is logical, can activating microcirculation and removing stasis medicinal and promoting qi circulation and relieving pain for " the gas medicine in blood " have sensible qi and blood function
Effect, therefore control all pains of the chest side of body of qi depression to blood stasis, abdomen.
Safflower: promoting menstruation, promoting blood circulation.Blood circulation, stasis eliminatings analgesic.Controlling through closing, abdominal mass, difficult labour, stillborn foetus, disease that postpartum lochia can't go,
Hemostasis is had a pain, carbuncle swells, injury from falling down.
Borneol: acrid flavour, hardship, it is slightly cold；Return heart, liver, lung channel；Delicate fragrance a surname dissipate has inducing resuscitation of having one's ideas straightened out heat-clearing dissipates poison, removing nebula
The effect of, cure mainly high fever and coma due to pyreticosis, apoplexy coma due to blocking of the respiratory system shies epilepsy, summer-heat and damp blinds clear key, throat deafness, aphtha tooth swells, sore carbuncle infantile malnutrition due to digestive disturbances or intestinalparasites hemorrhoid,
Red eye, swell pain, pterygium.All convulsive seizure due to phlegm-fire closing, sore throat hoarse voice, or intimately stop up stagnant, aphtha tooth swells person, borneol can be with cinnabar, boron
Sand, compound of glauber-salt and liquorice compatibility blow and put affected part on the skin, to dissipate fire removing toxic substances.
The auxiliary materials such as glycerol, vaseline, lanolin, azone, olive oil are added in the navel patch of the treatment dysmenorrhea, can enhance
The sterilization of medicament, antiseptic property, more conducively medicament molding.The effect of above each ingredient and effect are as follows:
Glycerol: effect: having the function of moisturizing, outside humectation, also have high activity, it is anti-oxidant, promote alcoholization.
Vaseline (white): effect: keeping skin wet, so that the skin histology of wound location is kept optimum state, accelerates
The repair ability of skin itself.In addition, vaseline is there is no sterilizing ability, it only block bacterium in air and
Skin contact, thus a possibility that reducing infection.
Lanolin: effect: moistness substance.It can make to dry because lacking natural moisture or rough skin softens and obtains
Restore.It is rather than moisture to be prevent completely to maintain the common water content of skin through epidermis by delay.
Olive oil: effect: antibacterial anti-inflammatory promotees to absorb, promote blood circulation, nourishing effect.
Azone: effect: bleeding agent.
In the above ingredient, the root of three-nerved spicebush enters Liver Channel, and energy soothing liver-qi stagnation, regulating qi-flowing for relieving pain are monarch drug in a prescription.
Radix rehmanniae preparata, Rhizoma Chuanxiong, corydalis tuber, safflower enter conscience, there is activating blood circulation, and the function of eliminating blood stasis and smoothing collaterals is promoting blood circulation, dredging channels, removing blood stasis and relieving pain
Main ingredient, be altogether monarch drug in a prescription with qi-activating drug.
The root bark of tree peony, cortex cinnamomi, radix aconiti lateralis preparata pungent-warm return heart, spleen, Liver Channel, the benefits of having the function of eliminating cold to stop pain in temperature, vital energy regualting and blood circulation-promoting can be increased
For ministerial drug.
Rhizoma alismatis is sweet light, clearing damp and promoting diuresis, the heat cold in nature for letting out kidney and bladder, damp-heat in lower-JIAO person especially be suitable for, with control pelvic inflammatory disease,
Fallopian tube adhesion, infertile, profuse leukorrhea, abdominal pain etc. are equipped with a meter shell, puckery intestines, analgesic.
Borneol can lead to all keys, dissipate stagnated fire, remove screen improving eyesight, swelling and pain relieving.
Radix achyranthis bidentatae first promoting blood circulation, second ensurings proper downward flow of the blood, to help the function of vital energy regualting and blood circulation-promoting.Radix Rehmanniae, pulp of dogwood fruit enter conscience, first
It enriches blood yin-nourishing, crossing for anti-promoting blood circulation and blood trouble, second relieving spasm to stop pain；Chinese yam, Poria cocos activating microcirculation and removing stasis medicinal invigorating the spleen again, can prevent row of largely invigorating blood circulation
The gas medicine impairment of the spleen and use.The above prescription gathers altogether is made patch, by SHENQUE acupoint (navel) be administered, have regulating the flow of vital energy and dispeling melancholy, it is promoting blood circulation and removing obstruction in channels,
The benefits of antalgic.
The navel patch of the treatment dysmenorrhea using its mutual collaboration or resists work by suitably cooperating a variety of drugs
With, compatibility, which goes out, can more preferably play drug effect and the navel patch specifically for dysmenorrhea, and it is significant in efficacy lasting, breach western medical treatment office
Limit, can the regulation of qi and blood to the maximum extent, improve blood circulation, promote and adjustment body immunity function, transfer human body in
Disease resistance, adjusts the balance of body and external environment, and adjusts the dynamic equilibrium of human body, regulating the flow of vital energy and dispeling melancholy, promoting blood circulation and removing obstruction in channels, Wen Jing
Analgesic, to achieve the purpose that cure disease.The navel patch treating both manifestation and root cause of disease of the treatment dysmenorrhea, without recurring, have no toxic side effect, make
With and it is easy to carry.
(4) specific embodiment
Below with reference to embodiment, the invention will be further described, but the present invention is not limited thereto.
Embodiment 1:
The navel patch of the treatment dysmenorrhea, active constituent are made of the raw material of following weight:
Radix Rehmanniae 6g, radix rehmanniae preparata 6g, pulp of dogwood fruit 8g, root bark of tree peony 8g, rhizoma alismatis 8g, Poria cocos 8g, cortex cinnamomi 3g, radix aconiti lateralis preparata 3g, Chinese yam 9g, ox
8 parts of knee, corydalis tuber 8g, root of three-nerved spicebush 8g, rice shell 4g, Rhizoma Chuanxiong 6g, safflower 6g, borneol 1g；
It further include the auxiliary material of following weight: glycerol 20g, vaseline 30g, lanolin 30g, azone 10g, olive oil 10g.
The preparation method of the navel patch of the treatment dysmenorrhea, using following steps:
A, take the Radix Rehmanniae of above-mentioned weight, radix rehmanniae preparata, pulp of dogwood fruit, the root bark of tree peony, rhizoma alismatis, Poria cocos, cortex cinnamomi, radix aconiti lateralis preparata, Chinese yam, radix achyranthis bidentatae,
Corydalis tuber, the root of three-nerved spicebush, rice shell, Rhizoma Chuanxiong, safflower mixing, machinery are smashed into 10 mesh grade micro mists；
B, the step a micro mist crushed is placed in percolator, is continuously added 75% ethanol solution and carries out diacolation, collects and leach
Micro mist after liquid and diacolation, it is spare；The weight for the 75% total ethanol solution being added is 6 times of micropowder weight；
C, the micro mist after step b diacolation is taken out into drying, continues to be crushed to 400 mesh or nanoscale fine powder；
D, the leachate of step b is concentrated under reduced pressure into no ethanol flavor, recycles ethyl alcohol, obtains concentrate；Then thin with step c
Powder mixing stirs evenly；
E, take the auxiliary material of above-mentioned weight: glycerol, vaseline, lanolin, olive oil and azone are mixed and are stirred evenly；
F, by the mixed material of step d and step e mix be placed in the vortex mixer of 20000rmp/min mix to
Ointment shape, weighing are shaped as pellet, 1 ball/3g, be made patch to get.
Usage and dosage: this navel patch alignment navel is attached, rear drug user is sticked and is comfortable on.Patient can be expert at before menstruation
It is used during 2-3 days or menstrual period, general patch can be alleviated significantly after 2-3 days and eliminate symptom.Every patch can be used 24 hours.
Embodiment 2:
The navel patch of the treatment dysmenorrhea, active constituent are made of the raw material of following weight:
Radix Rehmanniae 4g, radix rehmanniae preparata 4g, pulp of dogwood fruit 4g, root bark of tree peony 4g, rhizoma alismatis 4g, Poria cocos 4g, cortex cinnamomi 1g, radix aconiti lateralis preparata 1g, Chinese yam 5g, ox
4 parts of knee, corydalis tuber 4g, root of three-nerved spicebush 4g, rice shell 1g, Rhizoma Chuanxiong 2g, safflower 2g, borneol 0.5g；
It further include the auxiliary material of following weight: glycerol 15g, vaseline 20g, lanolin 20g, azone 5g, olive oil 5g.
The preparation method of the navel patch of the treatment dysmenorrhea, using following steps:
A, take the Radix Rehmanniae of above-mentioned weight, radix rehmanniae preparata, pulp of dogwood fruit, the root bark of tree peony, rhizoma alismatis, Poria cocos, cortex cinnamomi, radix aconiti lateralis preparata, Chinese yam, radix achyranthis bidentatae,
Corydalis tuber, the root of three-nerved spicebush, rice shell, Rhizoma Chuanxiong, safflower mixing, machinery are smashed into 20 mesh grade micro mists；
B, the step a micro mist crushed is placed in percolator, is continuously added 75% ethanol solution and carries out diacolation, collects and leach
Micro mist after liquid and diacolation, it is spare；The weight for the 75% total ethanol solution being added is 4 times of micropowder weight；
C, the micro mist after step b diacolation is taken out into drying, continues to be crushed to 200 mesh or nanoscale fine powder；
D, the leachate of step b is concentrated under reduced pressure into no ethanol flavor, recycles ethyl alcohol, obtains concentrate；Then thin with step c
Powder mixing stirs evenly；
E, take the auxiliary material of above-mentioned weight: glycerol, vaseline, lanolin, azone and olive oil are mixed and are stirred evenly；
F, by the mixed material of step d and step e mix be placed in the vortex mixer of 18000rmp/min mix to
Ointment shape, weighing are shaped as pellet, 1 ball/3g, be made patch to get.
Usage and dosage is with embodiment 1, and and will not be described here in detail.
Embodiment 3:
The navel patch of the treatment dysmenorrhea, active constituent are made of the raw material of following weight:
Radix Rehmanniae 8g, radix rehmanniae preparata 10g, pulp of dogwood fruit 10g, root bark of tree peony 12g, rhizoma alismatis 12g, Poria cocos 12g, cortex cinnamomi 5g, radix aconiti lateralis preparata 5g, Chinese yam
15g, 12 parts of radix achyranthis bidentatae, corydalis tuber 12g, root of three-nerved spicebush 12g, rice shell 6g, Rhizoma Chuanxiong 10g, safflower 10g, borneol 2g；
It further include the auxiliary material of following weight: glycerol 25g, vaseline 40g, lanolin 40g, azone 15g, olive oil 15g.
The preparation method of the navel patch of the treatment dysmenorrhea, using following steps:
A, take the Radix Rehmanniae of above-mentioned weight, radix rehmanniae preparata, pulp of dogwood fruit, the root bark of tree peony, rhizoma alismatis, Poria cocos, cortex cinnamomi, radix aconiti lateralis preparata, Chinese yam, radix achyranthis bidentatae,
Corydalis tuber, the root of three-nerved spicebush, rice shell, Rhizoma Chuanxiong, safflower mixing, machinery are smashed into 10 mesh grade micro mists；
B, the step a micro mist crushed is placed in percolator, is continuously added 75% ethanol solution and carries out diacolation, collects and leach
Micro mist after liquid and diacolation, it is spare；The weight for the 75% total ethanol solution being added is 8 times of micropowder weight；
C, the micro mist after step b diacolation is taken out into drying, continues to be crushed to 300 mesh or nanoscale fine powder；
D, the leachate of step b is concentrated under reduced pressure into no ethanol flavor, recycles ethyl alcohol, obtains concentrate；Then thin with step c
Powder mixing stirs evenly；
E, take the auxiliary material of above-mentioned weight: glycerol, vaseline, lanolin, azone and olive oil are mixed and are stirred evenly；
F, by the mixed material of step d and step e mix be placed in the vortex mixer of 20000rmp/min mix to
Ointment shape, weighing are shaped as pellet, 1 ball/3g, be made patch to get.
Usage and dosage is with embodiment 1, and and will not be described here in detail.
Embodiment 4:
The navel patch of the treatment dysmenorrhea, active constituent are made of the raw material of following weight:
Radix Rehmanniae 5g, radix rehmanniae preparata 5g, pulp of dogwood fruit 6g, root bark of tree peony 6g, rhizoma alismatis 6g, Poria cocos 6g, cortex cinnamomi 2g, radix aconiti lateralis preparata 2g, Chinese yam 7g, ox
6 parts of knee, corydalis tuber 6g, root of three-nerved spicebush 6g, rice shell 2g, Rhizoma Chuanxiong 4g, safflower 4g, borneol 1g；
It further include the auxiliary material of following weight: glycerol 17g, vaseline 25g, lanolin 25g, azone 8g, olive oil 8g.
Preparation method and usage and dosage are with embodiment 1, and and will not be described here in detail.
Embodiment 5:
The navel patch of the treatment dysmenorrhea, active constituent are made of the raw material of following weight:
Radix Rehmanniae 7g, radix rehmanniae preparata 8g, pulp of dogwood fruit 9g, root bark of tree peony 10g, rhizoma alismatis 10g, Poria cocos 10g, cortex cinnamomi 4g, radix aconiti lateralis preparata 4g, Chinese yam
12g, 10 parts of radix achyranthis bidentatae, corydalis tuber 10g, root of three-nerved spicebush 10g, rice shell 5g, Rhizoma Chuanxiong 8g, safflower 8g, borneol 2g；
It further include the auxiliary material of following weight: glycerol 23g, vaseline 35g, lanolin 35g, azone 12g, olive oil 12g.
Preparation method and usage and dosage are with embodiment 2, and and will not be described here in detail.
Clinical observation:
One) clinical test has been carried out using curative effect of the navel patch of the present invention to treatment female primary dysmenorrhea.Observation altogether
Primary dysmenorrhea case 240, wherein treatment group 120, each 60 of two control groups, observe result: treatment group's obvious effective rate
85.8%, control group obvious effective rate is respectively 56.6% and 55%, is handled through analysis, and there were significant differences for treatment group and control group, is controlled
Treatment group is better than control group, meanwhile, do not find that the medicine has obvious adverse reaction；It the following is clinical study results:
Case selection:
One, diagnostic criteria is formulated referring to " guideline of clinical investigations of new Chinese medicine treatment dysmenorrhea ".
(1), tcm diagnosis standard
Women is all, and in menstrual period or before menstruation after, the periodical hypogastralgia of appearance is primary symptom (within 1 week), uncomfortable with other,
So that influencing work and life can examine as dysmenorrhea.
(2), Chinese medical discrimination
1, syndrome of qi stagnation and blood stasis: distention and pain in the lower abdomen before or during menstruation tenderness, blood volume is few, blockage of menstruation, and color purple is dim block, block
Lower pain reprieves, premenstrual swollen breasts, discomfort uncomfortable in chest, and tongue is dim-purple or has petechia, veins string.
2, cold-dampness, which stagnates, demonstrate,proves: premenstrual or cold-type pain in the lower abdomen during menstruation, pain alleviated while getting warmth, delayed menstrual cycle, amount is few, and menses are dim and have stasis of blood block
Or such as semen sojae atricolor sweat sample, chilly, the hands and feet being not warm, profuse leukorrhea, tongue fur is white or greasy, veins string or heavy tight.
(3) Western medicine diagnostic criteria
Primary dysmenorrhea: refer to that reproductive organs is without significant organic pathology person, after mostly occurring in menarche through gynecologial examination
The adolescent girls of 2-3 or the young woman that do not give birth to.
(4) dysmenorrhea weight is grouped standard
1, severe: menstrual period or front and back underbelly are in great pain, feel restless, and seriously affect work, study and daily life, must
It must lie up, ache with waist, complexion white light is white, dripping cold sweat, peripheral coldness, vomiting and diarrhoea or rectal tenesmus, uses
Analgesic measure is not relieved.
2, moderate: underbelly is in great pain before and after menstrual period or menstrual period, aches with waist, nausea and vomiting, four limbs are not warm, with analgesic
Rotation pain is arranged to postpone.
3, slight: menstrual period or its front and back underbelly pain are obvious, ache with waist, but can adhere to work, no constitutional symptom has
When need to take anodyne.
Two, it is included in case standard:
Meet dysmenorrhea diagnostic criteria, belong to primary dysmenorrhea, be qi depression to blood stasis by Chinese medical discrimination, cold-dampness, which stagnates, demonstrate,proves marquis, does not make
Its invalid patient of medicine treatment is taken with/taking the treatment of its medicine or use/.
Three, exclusion criteria:
Meet dysmenorrhea diagnostic criteria, but belong to acquired dysmenorrhea, genitals have apparent organic disease person, examine through gynaecology
It looks into, the check-up such as B ultrasound, laparoscope have pelvic inflammatory disease, fibroid, endometriosis etc., or do not meet above-mentioned two Chinese medicine
Card type, the serious primary diseases such as merging angiocarpy, liver, kidney and hemopoietic system, mental patient, possible those who are allergic to this drug, no
Meet the standard of being included in, not by regulation medication, can not judge that curative effect or data be not congruent and affect the treatment or safety judgement person.
Observation method:
One, checking research are carried out using single blind randomized.In May, 13 in May, 15 is seen a doctor and meets the 240 of alternative condition
Example primary dysmenorrhea person is divided into treatment group and control group.Treatment group 120, control group each 60.
Two, application method
Treatment group: starting the navel patch of this treatment of docile dysmenorrhea for 3 days before menstrual onset, every time 1 patch, every patch 18-24h, and 3
Days as a treatment course are continuously taken three menstrual cycles, six menstrual cycles of clinical recovery case follow-up.
Control group 1: 3 days oral tablet of Corydalis tuber for alleviating pains before menstrual onset, 4 tablets once, 3 times a day, 3 days as one therapeutic course, and continuously
It takes three menstrual cycles, six menstrual cycles of clinical recovery example follow-up.
Control group 2: 3 days beginning docile dysmenorrhea plasters before menstrual onset are affixed on lower abdomen (lower 3 cun of navel), and it is small that every note continues 24
When, menstruation is thrown off in 12 hours after coming, and each menstrual cycle three pastes, and three months are as a treatment course.Clinical recovery case follow-up six
A menstrual cycle.
Three, observation index
1, the symptom situation of change of clinical manifestation, the pain degree of dysmenorrhea and duration.
2, the variation of menstrual cycle, amount, color, matter.
Treatment results:
One, curative effect determinate standard: " guideline of clinical investigations of new Chinese medicine treatment dysmenorrhea " system is issued according to the Ministry of Public Health
This fixed criterion of therapeutical effect.
1, fully recover: abdominal pain and other symptoms disappear after medication or docile navel patch, and 3 menstrual cycles of being discontinued do not recur
Person.
2, effective: abdominal pain is substantially reduced after medication or docile navel patch, remaining symptom improves, and not having to navel patch can be hard
Hold work.
3, effectively: abdominal pain mitigates after medication or docile navel patch, remaining symptom improves, docile navel patch can adhere to work
Make.
4, invalid: abdominal pain and other symptoms are without changer.
Two, total effects compare:
| Group | Recovery from illness | It is effective | Effectively | In vain | Obvious effective rate % |
| Treatment group | 60 | 43 | 14 | 3 | 85.8 |
| Control group 1 | 18 | 16 | 15 | 11 | 56.6 |
| Control group 2 | 19 | 14 | 13 | 14 | 55.0 |
Show that treatment group's curative effect is much better than control group by upper table.
Two) effect treated to navel patch of the present invention treatment women acquired dysmenorrhea has carried out clinical test.It observes altogether secondary
Property dysmenorrhea pathology 240, result: treatment group's obvious effective rate 84.2%, is observed by wherein treatment group 120 by control group each 60, control
1 obvious effective rate 55% of group, 2 obvious effective rate 56.7% of control group.It is handled through analysis, there were significant differences for treatment group and control group, treatment group
Better than control group, meanwhile, do not find that the medicine has obvious adverse reaction.
Case selection:
One, diagnostic criteria is formulated referring to " guideline of clinical investigations of new Chinese medicine treatment dysmenorrhea ".
(1), tcm diagnosis standard
Women is all, and in menstrual period or before menstruation after, the periodical hypogastralgia of appearance is primary symptom (within 1 week), uncomfortable with other,
So that influencing work and life can examine as dysmenorrhea.
(2), Chinese medical discrimination
Compared with modern medicine from anatomic angle to the understanding of disease mechanism, traditional Chinese medicine thinks, the pain hair of dysmenorrhea
Raw is that dirty ride its " qi and blood " is run at all.Internal organs QI-blood circulation is unsmooth, can cause pain because of " obstructed "；Internal organs qi and blood is not
Foot cannot support uterus, can cause pain because of part " not flourish ".The former is reality dysmenorrhea, and the latter is void dysmenorrhea.Reality epilepsy
Through that can cause because of factors such as cold solidifying, the stagnation of the circulation of vital energy, dampness, void dysmenorrhea is then malnutritive because of ferritic deficiency, the day after tomorrow, and because of menstrual flow
Caused by qi and blood caused by the reasons such as more, experience operation is lost.
(3) Western medicine diagnostic criteria
Acquired dysmenorrhea: be because of pelvic cavity organic disease caused by dysmenorrhea.Pelvioscopy and other auxiliary examinations often have different
The reason of often finding, secondary dysmenorrhoea can be found out.
(4) dysmenorrhea weight is grouped standard
1, severe: menstrual period or front and back underbelly are in great pain, feel restless, and seriously affect work, study and daily life, must
It must lie up, ache with waist, complexion white light is white, dripping cold sweat, peripheral coldness, vomiting and diarrhoea or rectal tenesmus, uses
Analgesic measure is not relieved.
2, moderate: underbelly is in great pain before and after menstrual period or menstrual period, aches with waist, nausea and vomiting, four limbs are not warm, with analgesic
Rotation pain is arranged to postpone.
3, slight: menstrual period or its front and back underbelly pain are obvious, ache with waist, but can adhere to work, no constitutional symptom has
When need to take anodyne.
Two, it is included in case standard:
Meet dysmenorrhea diagnostic criteria, belong to acquired dysmenorrhea, by Chinese medical discrimination be it is dirty to ride its " qi and blood " operation unsmooth and insufficient,
Be not used/take the treatment of its medicine or use/take its invalid patient of medicine treatment.
Three, exclusion criteria:
Meet dysmenorrhea diagnostic criteria, but belong to primary dysmenorrhea, or do not meet above-mentioned TCM Syndrome Type, mental patient may
Those who are allergic to this drug do not meet the standard of being included in, and not by regulation medication, can not judge that curative effect or data be not congruent and affect the treatment or pacify
Full property judgement person.
For example above-mentioned primary dysmenorrhea clinical treatment data of observation method, and will not be described here in detail.
Treatment results:
One, curative effect determinate standard: " guideline of clinical investigations of new Chinese medicine treatment dysmenorrhea " system is issued according to the Ministry of Public Health
This fixed criterion of therapeutical effect.
1, fully recover: abdominal pain and other symptoms disappear after medication or docile navel patch, and 3 menstrual cycles of being discontinued do not recur
Person.
2, effective: abdominal pain is substantially reduced after medication or docile navel patch, remaining symptom improves, and not having to navel patch can be hard
Hold work.
3, effectively: abdominal pain mitigates after medication or docile navel patch, remaining symptom improves, docile navel patch can adhere to work
Make.
4, invalid: abdominal pain and other symptoms are without changer.
Two, total effects compare:
| Group | Recovery from illness | It is effective | Effectively | In vain | Obvious effective rate % |
| Treatment group | 59 | 42 | 16 | 3 | 84.2 |
| Control group 1 | 17 | 16 | 16 | 11 | 55.0 |
| Control group 2 | 18 | 16 | 13 | 13 | 56.7 |
Show that treatment group's curative effect is much better than control group by upper table.
Claims (2)
1. a kind of navel patch for treating dysmenorrhea, it is characterized in that: the navel patch is made of active constituent and auxiliary material,
The active constituent is prepared from the following raw materials in parts by weight:
4-8 parts of Radix Rehmanniae, 4-10 parts of radix rehmanniae preparata, 4-10 parts of pulp of dogwood fruit, 4-12 parts of the root bark of tree peony, 4-12 parts of rhizoma alismatis, 4-12 parts of Poria cocos, cortex cinnamomi 1-
5 parts, 1-5 parts of radix aconiti lateralis preparata, 5-15 parts of Chinese yam, 4-12 parts of radix achyranthis bidentatae, 4-12 parts of corydalis tuber, 4-12 parts of the root of three-nerved spicebush, 1-6 parts of rice shell, Rhizoma Chuanxiong 2-
10 parts, 2-10 parts of safflower, 0.5-2 parts of borneol；
The auxiliary material is made of following component in parts by weight: 15-25 parts of glycerol, 20-40 parts of vaseline, lanolin 20-40
Part, 5-15 parts of azone, 5-15 parts of olive oil；
The preparation method of the navel patch of the treatment dysmenorrhea, includes the following steps:
A, take the Radix Rehmanniaes of above-mentioned parts by weight, radix rehmanniae preparata, pulp of dogwood fruit, the root bark of tree peony, rhizoma alismatis, Poria cocos, cortex cinnamomi, radix aconiti lateralis preparata, Chinese yam, radix achyranthis bidentatae,
Corydalis tuber, the root of three-nerved spicebush, rice shell, Rhizoma Chuanxiong, safflower mixing, machinery are smashed into 10-20 mesh grade micro mist；
B, the step a micro mist crushed is placed in percolator, be continuously added 75% ethanol solution carry out diacolation, collect leachate and
Micro mist after diacolation, it is spare；The weight for the 75% total ethanol solution being added is 4-8 times of micropowder weight；
C, the micro mist after step b diacolation is taken out into drying, continues to be crushed to 200-400 mesh or nanoscale fine powder；
D, the leachate of step b is concentrated, then mixes and stirs evenly with the fine powder of step c；
E, take the auxiliary material of above-mentioned parts by weight: glycerol, vaseline, lanolin, azone and olive oil are mixed and are stirred evenly；
F, the mixed material of step d and step e are mixed and added into the borneol of above-mentioned parts by weight, mixes to being in ointment shape, claims
Be shaped as pellet again, be made patch to get.
2. a kind of navel patch for treating dysmenorrhea according to claim 1, it is characterized in that: its active constituent is by following weight
The raw material of number is made:
6 parts of Radix Rehmanniae, 6 parts of radix rehmanniae preparata, 8 parts of pulp of dogwood fruit, 8 parts of the root bark of tree peony, 8 parts of rhizoma alismatis, 8 parts of Poria cocos, 3 parts of cortex cinnamomi, 3 parts of radix aconiti lateralis preparata, Chinese yam 9
Part, 8 parts of radix achyranthis bidentatae, 8 parts of corydalis tuber, 4 parts of 8 part, meter shell of the root of three-nerved spicebush, 6 parts of Rhizoma Chuanxiong, 6 parts of safflower, 1 part of borneol；
The auxiliary material is made of following component in parts by weight: 20 parts of glycerol, 30 parts of vaseline, 30 parts of lanolin, olive oil
10 parts, 10 parts of azone.
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| CN108014298A (en) * | 2017-12-19 | 2018-05-11 | 王继彩 | A kind of Chinese medicine composition for treating dysmenorrhoea and preparation method thereof |
| CN108030870A (en) * | 2018-01-18 | 2018-05-15 | 杨学生 | It is a kind of to treat protrusion of lumber intervertebral disc and the plaster of bone fracture and preparation method thereof |
| CN110575460A (en) * | 2019-09-24 | 2019-12-17 | 佘建华 | external patch for improving immunity and preparation method thereof |
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|---|---|---|---|---|
| CN1089150A (en) * | 1993-01-03 | 1994-07-13 | 贵州三力技术发展有限公司 | A kind of acupoint adhesive plaster for the treatment of dysmenorrhea |
| CN1772154A (en) * | 2005-10-24 | 2006-05-17 | 李亚萍 | Chinese herbal medicine decoction for treating premenstrual abdominal pain and its prepn |
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2015
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1089150A (en) * | 1993-01-03 | 1994-07-13 | 贵州三力技术发展有限公司 | A kind of acupoint adhesive plaster for the treatment of dysmenorrhea |
| CN1772154A (en) * | 2005-10-24 | 2006-05-17 | 李亚萍 | Chinese herbal medicine decoction for treating premenstrual abdominal pain and its prepn |
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| 止痛化瘀汤治疗原发性痛经45例;苏颖;《陕西中医》;20050525;第26卷(第5期);第398页 * |
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