CN104970806A - Smart device used for cancer relapse real-time dynamic monitoring - Google Patents
Smart device used for cancer relapse real-time dynamic monitoring Download PDFInfo
- Publication number
- CN104970806A CN104970806A CN201510406730.6A CN201510406730A CN104970806A CN 104970806 A CN104970806 A CN 104970806A CN 201510406730 A CN201510406730 A CN 201510406730A CN 104970806 A CN104970806 A CN 104970806A
- Authority
- CN
- China
- Prior art keywords
- wireless communication
- albumen
- module
- assembly
- communication module
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 206010028980 Neoplasm Diseases 0.000 title claims abstract description 85
- 201000011510 cancer Diseases 0.000 title claims abstract description 77
- 238000012544 monitoring process Methods 0.000 title claims abstract description 34
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 51
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 51
- 239000008280 blood Substances 0.000 claims abstract description 41
- 210000004369 blood Anatomy 0.000 claims abstract description 41
- 238000004891 communication Methods 0.000 claims description 51
- 238000010438 heat treatment Methods 0.000 claims description 46
- 230000027455 binding Effects 0.000 claims description 45
- 230000001939 inductive effect Effects 0.000 claims description 45
- 238000005057 refrigeration Methods 0.000 claims description 34
- 102000004506 Blood Proteins Human genes 0.000 claims description 32
- 108010017384 Blood Proteins Proteins 0.000 claims description 32
- 239000002070 nanowire Substances 0.000 claims description 26
- 230000005059 dormancy Effects 0.000 claims description 22
- 238000012545 processing Methods 0.000 claims description 13
- 238000006243 chemical reaction Methods 0.000 claims description 11
- 230000001052 transient effect Effects 0.000 claims description 11
- 238000004458 analytical method Methods 0.000 claims description 8
- 230000009870 specific binding Effects 0.000 claims description 6
- 238000004020 luminiscence type Methods 0.000 claims description 4
- 210000000056 organ Anatomy 0.000 claims description 4
- 238000000338 in vitro Methods 0.000 abstract description 6
- 206010027476 Metastases Diseases 0.000 abstract description 2
- 230000009401 metastasis Effects 0.000 abstract description 2
- 238000002513 implantation Methods 0.000 abstract 2
- 238000001727 in vivo Methods 0.000 abstract 2
- 230000005540 biological transmission Effects 0.000 abstract 1
- 239000003147 molecular marker Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 description 10
- 230000008569 process Effects 0.000 description 10
- 239000000427 antigen Substances 0.000 description 6
- 102000036639 antigens Human genes 0.000 description 6
- 108091007433 antigens Proteins 0.000 description 6
- 230000008859 change Effects 0.000 description 6
- 238000013459 approach Methods 0.000 description 5
- 238000001514 detection method Methods 0.000 description 5
- 230000003993 interaction Effects 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 238000012546 transfer Methods 0.000 description 5
- 230000002411 adverse Effects 0.000 description 4
- 230000036541 health Effects 0.000 description 4
- 239000000439 tumor marker Substances 0.000 description 4
- 102000027450 oncoproteins Human genes 0.000 description 3
- 108091008819 oncoproteins Proteins 0.000 description 3
- 230000002980 postoperative effect Effects 0.000 description 3
- 210000000707 wrist Anatomy 0.000 description 3
- 238000003745 diagnosis Methods 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 230000000266 injurious effect Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 210000002751 lymph Anatomy 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
Landscapes
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Abstract
The present invention discloses a smart device used for cancer relapse real-time dynamic monitoring. The smart device comprises an in vivo implantation assembly and an in vitro assembly, wherein the in vivo implantation assembly can convert tumor markers protein information in the blood to transmittable digital information which is transmitted to the in vitro assembly in a wireless transmission manner, and the in vitro assembly analyzes the received protein information and notifies an implantable cancer relapse real-time monitoring system user to notice the danger of cancer relapse by information display and alarm manners. The smart device provided by the present invention can monitor molecular marker protein of cancer relapse/metastasis in real time, and can detect the danger of cancer relapse at the early stage, thereby enabling the relapsed patient to acquire timely treatment.
Description
Technical field
The invention belongs to medical instruments field, relate to a kind of smart machine, be specifically related to a kind of smart machine for cancer return real-time dynamic monitoring.
Background technology
The curative competence of current China cancer is also not fully up to expectations, and in whole cancer patient, nearly 1/3 can be cured, and obtains the chance of long term survival, but also has the cancer patient about half to occur relapse and metastasis in the course of disease.Cancer return refers to that the cancer be brought under control occurs again on former hair device official, or cancer invades lymph vessels or body cavity from original site, moves to elsewhere continued growth, forms the tumor with primary tumor same-type.Some cancer can first treatment after some months or recur after several years.Therefore for cancer patient, the monitoring carrying out postoperative recurrence transfer is very important.The sign of cancer return transfer find more early, just can take counter-measure in time, the probability that effective suppression cancer return shifts, the life cycle that prolongation cancer patient is postoperative.
The mode of current patient monitoring cancer return mainly regularly arrives hospital and checks, and this mode is for patient, and one is inconvenient, and expend time in, two is check not in time, likely misses the probability of early discovery cancer return.Conveniently cancer patient can check oneself the recurrence of cancer timely, study a kind of can Real-Time Monitoring cancer patient recurrence equipment be necessary.
Summary of the invention
In order to solve the deficiencies in the prior art, the object of the present invention is to provide a kind of smart machine for cancer return real-time dynamic monitoring, described smart machine completes the monitoring to cancer return by the level of oncoprotein matter in monitoring of blood.Described smart machine arranges the threshold value of the level of oncoprotein matter in a blood, when detecting that the level of oncoprotein matter in blood reaches or exceedes this threshold value, described smart machine then can notify by the mode given the alarm that monitoring system wearer cancer return may occur, cancer patient just can arrive hospital in time and make a definite diagnosis, and enables the state of an illness obtain control early.
To achieve these goals, this invention takes following technical scheme:
For a smart machine for cancer return real-time dynamic monitoring, described smart machine comprises et al. Ke assembly 1 and external assembly 2; Described et al. Ke assembly 1 comprises blood protein sensor 11, data processing module 12, first wireless communication module 13; Described blood protein sensor 11 comprises albumen trapping layer 111, binding signal inductive layer 112, heating module 113, refrigeration module 114, containment vessel 115; Described albumen trapping layer 111 sticks on binding signal inductive layer 112, described containment vessel 115 covers in described albumen trapping layer 111 for described albumen trapping layer 111 being opened with blood separating, described heating module 113 for by the transient heating of described albumen sensor 11 to more than 56 DEG C, described refrigeration module 114 is for being reduced to physiological temp instantaneously by the temperature of the described albumen sensor 11 heated; Described data processing module 12 comprises input interface 121, microprocessor 122, output interface 123, reactor 124; Described input interface 121 receives the electrochemical signals of described blood protein sensor 11 output and inputs described microprocessor 122 after it is converted into digital signal, is uploaded to described external assembly 2 after described microprocessor 122 pairs of digital signals carry out protocol conversion by described output interface 123 via described first wireless communication module 13; Described external assembly 2 comprises data receiver 21, and described data receiver 21 comprises controller 211, display 212, siren 213, second wireless communication module 214; Described controller 211 receives and analyzes the protein signal that described et al. Ke assembly 1 uploads, afterwards Protein Information is sent on described display 212 and shows, the analysis programme of described controller 211 arranges a threshold value, when this threshold value of horizontal exceeding of albumen, described controller 211 sends instruction to described siren 213, described siren 213 gives the alarm, and notifies that wearer notes the danger of cancer return; The control command of described controller 211 passes on the described reactor 124 in described et al. Ke assembly 1 by described second wireless communication module 214, and described reactor 124 controls the unlatching of described containment vessel 115 or closedown, the startup of the described heating module of control 113 or dormancy, the startup of the described refrigeration module 114 of control or dormancy.
Further, described external assembly 2 also comprises intelligent mobile terminal equipment 22, described data receiver 21 also comprises the 3rd wireless communication module 215, and tumor marker protein information is sent in described intelligent mobile terminal equipment 22 by described 3rd wireless communication module 215 by described controller 211.
Described intelligent mobile terminal equipment 22 can be smart mobile phone, flat board or computer.
Further, described siren 213 is vibrators, notifies that wearer notes the danger of cancer return by the mode of vibration.
Further, described siren 213 is luminous organs, notifies that wearer notes the danger of cancer return by the mode of luminescence.
Further, described albumen trapping layer 111 is made up of the antibody with blood protein specific binding.
Further, described binding signal inductive layer 112 is made up of array of nanowire transistors.
The combination of described albumen trapping layer 111 of the present invention and described binding signal inductive layer 112 is the antibody surface of nano-wire transistor being covered with one deck target protein.
The operation principle of described blood protein sensor 11 of the present invention is: when after the antibodies on the tumor markers-target protein in blood and described albumen trapping layer 111, with the electron interaction of the nano-wire transistor top layer movement on described binding signal inductive layer 112, change the electric conductivity of nano-wire transistor, before and after being combined by comparison target protein, the difference of the electric conductivity of nano-wire transistor, can know the concentration information of target protein in blood.
The kind of the antibody in albumen trapping layer 111 of the present invention determines according to the target protein of antibody capture.The target protein satisfied condition is the mark of cancer return and transfer, and the concentration namely by detecting target protein can judge whether cancer recurs or again shift.The antibody that the marker protein of every cancer return and transfer is corresponding all can be used for the present invention.
Further, described first wireless communication module 13, described second wireless communication module 214, described 3rd wireless communication module 215 adopt any one in Bluetooth protocol or Zigbee protocol.
Further, described data receiver 12 can be worn at any part on cancer patient's health, is preferably worn in wrist.In addition, described data receiver 12 also can not be worn on a certain position of health of cancer patient, but uses as in vitro accessory.
Further, the timing of described controller 211 realize the control to the unlatching of described containment vessel 115 or closedown, the startup to heating module 113 or dormancy control, to the startup of refrigeration module 114 or the control of dormancy.The interval time of continuously adjustabe between 1s to 1800s that control command is assigned, adjustment stepping is 2s.
The operational approach of the smart machine for cancer return real-time dynamic monitoring of the present invention:
(1) described et al. Ke assembly 1 is implanted in blood;
(2) issue an order to described reactor 124 by described controller 211 and make it to control the unlatching of described containment vessel 115, at this moment described albumen trapping layer 111 and contacting blood, target protein and antibodies;
(3) after reacting certain hour, issue an order to described reactor 124 to make it to control described heating module 113 by described controller 211 and start, described albumen trapping layer 111 and described binding signal inductive layer 112 transient temperature is caused to reach more than 56 DEG C, now, the antigen combined is separated with antibody, afterwards, described controller 211 issues an order to described reactor 124 to control described containment vessel 115 and cuts out, described albumen trapping layer 111 is isolated with blood, simultaneously described controller 211 is issued an order to described reactor 124 to control refrigeration module 114 and the temperature of described albumen trapping layer 111 and described binding signal inductive layer 112 is reduced to physiological temp, thus complete one-time detection.
(4) wearer of smart machine of the present invention is known by the information and the reaction of siren 213 of observing the display of described display 212 and whether be there occurs cancer return danger;
Described heating module 113 causes described albumen trapping layer 111 and described binding signal inductive layer 112 to be elevated to more than 56 DEG C, this process is instantaneous, and after heating the only extremely short time namely start described refrigeration module 114 and complete temperature-fall period, therefore in whole process to the composition in blood without any injurious effects.
Preferably, described heating module 113 causes described albumen trapping layer 111 and described binding signal inductive layer 112 to be elevated to 56 DEG C.Because under 56 DEG C of conditions, the antigen-antibody that combined is separated, more than the 56 DEG C separation that can realize conjugated antigen antibody too.
Advantage of the present invention and beneficial effect:
By the level detecting the tumor marker protein in blood, whether the smart machine that 1, the present invention is used for cancer return real-time dynamic monitoring judges that cancer patient is postoperative and recurs, the diagnosis of molecular level can be able to find in early days in recurrence, provides diagnostic base for taking corresponding treatment means effectively and timely.
2, the smart machine for cancer return real-time dynamic monitoring of the present invention can realize monitoring anywhere or anytime, reaches the object of real-time dynamic monitoring, and cancer patient can be made to grasp the current intelligence of cancer return transfer easily timely.
3, the smart machine for cancer return real-time dynamic monitoring of the present invention can reuse, this smart machine reaches the object of antigen-antibody coalition separation by the temperature controlling blood protein sensor, avoids the operation often detecting and once need again to implant smart machine afterwards.
Accompanying drawing explanation
Fig. 1 shows a kind of structural representation of the smart machine for cancer return real-time dynamic monitoring of the present invention;
Fig. 2 shows a kind of structural representation of the smart machine for cancer return real-time dynamic monitoring of the present invention;
Wherein, 1: et al. Ke assembly; 11: blood protein sensor; 111: albumen trapping layer; 112: binding signal inductive layer; 113: heating module; 114: refrigeration module; 115: containment vessel; 12: data processing module; 121: input interface, 122: microprocessor, 123: output interface; 124: reactor; 13: the first wireless communication modules; 2: external assembly; 21: data receiver; 211: controller; 212: display; 213: siren; 214: the second wireless communication modules; 215: the three wireless communication modules; 22: intelligent mobile terminal equipment.
Detailed description of the invention
Below in conjunction with specific embodiment, illustrate the present invention further.Should be understood that these embodiments are only not used in for illustration of the present invention to limit the scope of the invention.
Embodiment 1 one kinds of smart machines for cancer return real-time dynamic monitoring
For a smart machine for cancer return real-time dynamic monitoring, smart machine comprises et al. Ke assembly 1 and external assembly 2; Et al. Ke assembly 1 comprises blood protein sensor 11, data processing module 12, first wireless communication module 13; Blood protein sensor 11 comprises albumen trapping layer 111, binding signal inductive layer 112, heating module 113, refrigeration module 114, containment vessel 115; Albumen trapping layer 111 sticks on binding signal inductive layer 112, containment vessel 115 covers in albumen trapping layer 111 for albumen trapping layer 111 and blood separating being opened, heating module 113 for by albumen sensor 11 transient heating to more than 56 DEG C, refrigeration module 114 is for being reduced to physiological temp instantaneously by the temperature of the albumen heated sensor 11; Data processing module 12 comprises input interface 121, microprocessor 122, output interface 123, reactor 124; Input interface 121 receives the electrochemical signals input microprocessor 122 after it being converted into digital signal that blood protein sensor 11 exports, and is uploaded to external assembly 2 after microprocessor 122 pairs of digital signals carry out protocol conversion by output interface 123 via the first wireless communication module 13; External assembly 2 comprises data receiver 21, and data receiver 21 comprises controller 211, display 212, siren 213, second wireless communication module 214; Controller 211 receives and analyzing body is implanted into the protein signal that assembly 1 is uploaded, afterwards Protein Information is sent in display 212 and shows, the analysis programme of controller 211 arranges a threshold value, when this threshold value of horizontal exceeding of albumen, controller 211 sends instruction to siren 213, siren 213 gives the alarm, and notifies that wearer notes the danger of cancer return; The control command of controller 211 passes on the reactor 124 in et al. Ke assembly 1 by the second wireless communication module 214, the startup of the startup of the unlatching of reactor 124 Control protection shell 115 or closedown, control heating module 113 or dormancy, control refrigeration module 114 or dormancy.
Siren 213 is vibrators, notifies that wearer notes the danger of cancer return by the mode of vibration.
Albumen trapping layer 111 is made up of the antibody with blood protein specific binding.
Binding signal inductive layer 112 is made up of array of nanowire transistors.
The combination of albumen trapping layer 111 and binding signal inductive layer 112 is the antibody surface of nano-wire transistor being covered with one deck target protein.
The operation principle of blood protein sensor 11 is: when after the tumor markers-target protein in blood and the antibodies in albumen trapping layer 111, with the electron interaction of the nano-wire transistor top layer movement on binding signal inductive layer 112, change the electric conductivity of nano-wire transistor, before and after being combined by comparison target protein, the difference of the electric conductivity of nano-wire transistor, can know the concentration information of target protein in blood.
First wireless communication module 13, second wireless communication module 214 adopts Bluetooth protocol.
Data receiver 12 can be worn at any part on cancer patient's health, such as, be worn in wrist.
Controller 211 timing realize the control to the unlatching of described containment vessel 115 or closedown, the startup to heating module 113 or dormancy control, to the startup of refrigeration module 114 or the control of dormancy.The interval time of continuously adjustabe between 1s to 1800s that control command is assigned, adjustment stepping is 2s.
Heating module 113 causes albumen trapping layer 111 and binding signal inductive layer 112 to be elevated to more than 56 DEG C, this process is instantaneous, and after heating the only extremely short time namely start refrigeration module 114 and complete temperature-fall period, therefore in whole process to the composition in blood without any adverse influence.
Operational approach for the smart machine of cancer return real-time dynamic monitoring:
(1) et al. Ke assembly 1 is implanted in blood;
(2) issue an order to reactor 124 by controller 211 and make it the unlatching of Control protection shell 115, at this moment albumen trapping layer 111 and contacting blood, target protein and antibodies;
(3) after reacting certain hour, issue an order to reactor 124 to make it to control heating module 113 by controller 211 and start, albumen trapping layer 111 and binding signal inductive layer 112 transient temperature is caused to reach 56 DEG C, now, the antigen combined is separated with antibody, afterwards, controller 211 cuts out to reactor 124 Control protection shell 115 of issuing an order, albumen trapping layer 111 and blood are isolated, issue an order to reactor 124 to control refrigeration module 114 with Time Controller 211 and the temperature of albumen trapping layer 111 and binding signal inductive layer 112 is reduced to physiological temp, thus complete one-time detection,
(4) reaction of the information that shown by observation display 212 of the wearer of this smart machine and siren 213 is known and whether be there occurs cancer return danger.
Embodiment 2 one kinds of smart machines for cancer return real-time dynamic monitoring
For a smart machine for cancer return real-time dynamic monitoring, smart machine comprises et al. Ke assembly 1 and external assembly 2; Et al. Ke assembly 1 comprises blood protein sensor 11, data processing module 12, first wireless communication module 13; Blood protein sensor 11 comprises albumen trapping layer 111, binding signal inductive layer 112, heating module 113, refrigeration module 114, containment vessel 115; Albumen trapping layer 111 sticks on binding signal inductive layer 112, containment vessel 115 covers in albumen trapping layer 111 for albumen trapping layer 111 and blood separating being opened, heating module 113 for by albumen sensor 11 transient heating to more than 56 DEG C, refrigeration module 114 is for being reduced to physiological temp instantaneously by the temperature of the albumen heated sensor 11; Data processing module 12 comprises input interface 121, microprocessor 122, output interface 123, reactor 124; Input interface 121 receives the electrochemical signals input microprocessor 122 after it being converted into digital signal that blood protein sensor 11 exports, and is uploaded to external assembly 2 after microprocessor 122 pairs of digital signals carry out protocol conversion by output interface 123 via the first wireless communication module 13; External assembly 2 comprises data receiver 21, and data receiver 21 comprises controller 211, display 212, siren 213, second wireless communication module 214; Controller 211 receives and analyzing body is implanted into the protein signal that assembly 1 is uploaded, afterwards Protein Information is sent on display 212 and shows, the analysis programme of controller 211 arranges a threshold value, when this threshold value of horizontal exceeding of albumen, controller 211 sends instruction to siren 213, siren 213 gives the alarm, and notifies that wearer notes the danger of cancer return; The control command of controller 211 passes on the reactor 124 in et al. Ke assembly 1 by the second wireless communication module 214, the startup of the startup of the unlatching of reactor 124 Control protection shell 115 or closedown, control heating module 113 or dormancy, control refrigeration module 114 or dormancy.
Siren 213 is luminous organs, notifies that wearer notes the danger of cancer return by the mode of luminescence.
Albumen trapping layer 111 is made up of the antibody with blood protein specific binding.
Binding signal inductive layer 112 is made up of array of nanowire transistors.
The combination of albumen trapping layer 111 and binding signal inductive layer 112 is the antibody surface of nano-wire transistor being covered with one deck target protein.
The operation principle of blood protein sensor 11 is: when after the tumor markers-target protein in blood and the antibodies in albumen trapping layer 111, with the electron interaction of the nano-wire transistor top layer movement on binding signal inductive layer 112, change the electric conductivity of nano-wire transistor, before and after being combined by comparison target protein, the difference of the electric conductivity of nano-wire transistor, can know the concentration information of target protein in blood.
First wireless communication module 13, second wireless communication module 214 adopts Zigbee protocol.
Data receiver 12 uses as in vitro accessory.
Controller 211 timing realize the control to the unlatching of described containment vessel 115 or closedown, the startup to heating module 113 or dormancy control, to the startup of refrigeration module 114 or the control of dormancy.The interval time of continuously adjustabe between 1s to 1800s that control command is assigned, adjustment stepping is 2s.
Heating module 113 causes albumen trapping layer 111 and binding signal inductive layer 112 to be elevated to more than 56 DEG C, this process is instantaneous, and after heating the only extremely short time namely start refrigeration module 114 and complete temperature-fall period, therefore in whole process to the composition in blood without any adverse influence.
Operational approach for the smart machine of cancer return real-time dynamic monitoring:
(1) et al. Ke assembly 1 is implanted in blood;
(2) issue an order to reactor 124 by controller 211 and make it the unlatching of Control protection shell 115, at this moment albumen trapping layer 111 and contacting blood, target protein and antibodies;
(3) after reacting certain hour, issue an order to reactor 124 to make it to control heating module 113 by controller 211 and start, albumen trapping layer 111 and binding signal inductive layer 112 transient temperature is caused to reach 56 DEG C, now, the antigen combined is separated with antibody, afterwards, controller 211 cuts out to reactor 124 Control protection shell 115 of issuing an order, albumen trapping layer 111 and blood are isolated, issue an order to reactor 124 to control refrigeration module 114 with Time Controller 211 and the temperature of albumen trapping layer 111 and binding signal inductive layer 112 is reduced to physiological temp, thus complete one-time detection,
(4) reaction of the information that shown by observation display 212 of the wearer of this smart machine and siren 213 is known and whether be there occurs cancer return danger.
Embodiment 3 one kinds of smart machines for cancer return real-time dynamic monitoring
For a smart machine for cancer return real-time dynamic monitoring, smart machine comprises et al. Ke assembly 1 and external assembly 2; Et al. Ke assembly 1 comprises blood protein sensor 11, data processing module 12, first wireless communication module 13; Blood protein sensor 11 comprises albumen trapping layer 111, binding signal inductive layer 112, heating module 113, refrigeration module 114, containment vessel 115; Albumen trapping layer 111 sticks on binding signal inductive layer 112, containment vessel 115 covers in albumen trapping layer 111 for albumen trapping layer 111 and blood separating being opened, heating module 113 for by albumen sensor 11 transient heating to more than 56 DEG C, refrigeration module 114 is for being reduced to physiological temp instantaneously by the temperature of the albumen heated sensor 11; Data processing module 12 comprises input interface 121, microprocessor 122, output interface 123, reactor 124; Input interface 121 receives the electrochemical signals input microprocessor 122 after it being converted into digital signal that blood protein sensor 11 exports, and is uploaded to external assembly 2 after microprocessor 122 pairs of digital signals carry out protocol conversion by output interface 123 via the first wireless communication module 13; External assembly 2 comprises data receiver 21, and data receiver 21 comprises controller 211, display 212, siren 213, second wireless communication module 214; Controller 211 receives and analyzing body is implanted into the protein signal that assembly 1 is uploaded, afterwards Protein Information is sent on display 212 and shows, the analysis programme of controller 211 arranges a threshold value, when this threshold value of horizontal exceeding of albumen, controller 211 sends instruction to siren 213, siren 213 gives the alarm, and notifies that wearer notes the danger of cancer return; The control command of controller 211 passes on the reactor 124 in et al. Ke assembly 1 by the second wireless communication module 214, the startup of the startup of the unlatching of reactor 124 Control protection shell 115 or closedown, control heating module 113 or dormancy, control refrigeration module 114 or dormancy.
External assembly 2 also comprises intelligent mobile terminal equipment 22, and data receiver 21 also comprises the 3rd wireless communication module 215, and tumor marker protein information is sent in intelligent mobile terminal equipment 22 by the 3rd wireless communication module 215 by controller 211.Intelligent mobile terminal equipment 22 pairs of Protein Information carry out remote storage and analysis.
Intelligent mobile terminal equipment 22 can be smart mobile phone, flat board or computer.
Data receiver 12 can be worn on any part of cancer patient's health, such as wrist.
First wireless communication module 13, second wireless communication module 214, the 3rd wireless communication module 215 adopt Bluetooth protocol.
Siren 213 is vibrators, notifies that wearer notes the danger of cancer return by the mode of vibration.
Albumen trapping layer 111 is made up of the antibody with blood protein specific binding.
Binding signal inductive layer 112 is made up of array of nanowire transistors.
The combination of albumen trapping layer 111 and binding signal inductive layer 112 is the antibody surface of nano-wire transistor being covered with one deck target protein.
The operation principle of blood protein sensor 11 is: when after the tumor markers-target protein in blood and the antibodies in albumen trapping layer 111, with the electron interaction of the nano-wire transistor top layer movement on binding signal inductive layer 112, change the electric conductivity of nano-wire transistor, before and after being combined by comparison target protein, the difference of the electric conductivity of nano-wire transistor, can know the concentration information of target protein in blood.
Controller 211 timing realize the control to the unlatching of described containment vessel 115 or closedown, the startup to heating module 113 or dormancy control, to the startup of refrigeration module 114 or the control of dormancy.The interval time of continuously adjustabe between 1s to 1800s that control command is assigned, adjustment stepping is 2s.
Heating module 113 causes albumen trapping layer 111 and binding signal inductive layer 112 to be elevated to more than 56 DEG C, this process is instantaneous, and after heating the only extremely short time namely start refrigeration module 114 and complete temperature-fall period, therefore in whole process to the composition in blood without any adverse influence.
Operational approach for the smart machine of cancer return real-time dynamic monitoring:
(1) et al. Ke assembly 1 is implanted in blood;
(2) issue an order to reactor 124 by controller 211 and make it the unlatching of Control protection shell 115, at this moment albumen trapping layer 111 and contacting blood, target protein and antibodies;
(3) after reacting certain hour, issue an order to reactor 124 to make it to control heating module 113 by controller 211 and start, albumen trapping layer 111 and binding signal inductive layer 112 transient temperature is caused to reach 56 DEG C, now, the antigen combined is separated with antibody, afterwards, controller 211 cuts out to reactor 124 Control protection shell 115 of issuing an order, albumen trapping layer 111 and blood are isolated, issue an order to reactor 124 to control refrigeration module 114 with Time Controller 211 and the temperature of albumen trapping layer 111 and binding signal inductive layer 112 is reduced to physiological temp, thus complete one-time detection,
(4) reaction of the information that shown by observation display 212 or intelligent terminal 22 of the wearer of this smart machine and siren 213 is known and whether be there occurs cancer return danger.
Embodiment 4 one kinds of smart machines for cancer return real-time dynamic monitoring
For a smart machine for cancer return real-time dynamic monitoring, smart machine comprises et al. Ke assembly 1 and external assembly 2; Et al. Ke assembly 1 comprises blood protein sensor 11, data processing module 12, first wireless communication module 13; Blood protein sensor 11 comprises albumen trapping layer 111, binding signal inductive layer 112, heating module 113, refrigeration module 114, containment vessel 115; Albumen trapping layer 111 sticks on binding signal inductive layer 112, containment vessel 115 covers in albumen trapping layer 111 for albumen trapping layer 111 and blood separating being opened, heating module 113 for by albumen sensor 11 transient heating to more than 56 DEG C, refrigeration module 114 is for being reduced to physiological temp instantaneously by the temperature of the albumen heated sensor 11; Data processing module 12 comprises input interface 121, microprocessor 122, output interface 123, reactor 124; Input interface 121 receives the electrochemical signals input microprocessor 122 after it being converted into digital signal that blood protein sensor 11 exports, and is uploaded to external assembly 2 after microprocessor 122 pairs of digital signals carry out protocol conversion by output interface 123 via the first wireless communication module 13; External assembly 2 comprises data receiver 21, and data receiver 21 comprises controller 211, display 212, siren 213, second wireless communication module 214; Controller 211 receives and analyzing body is implanted into the protein signal that assembly 1 is uploaded, afterwards Protein Information is sent on display 212 and shows, the analysis programme of controller 211 arranges a threshold value, when this threshold value of horizontal exceeding of albumen, controller 211 sends instruction to siren 213, siren 213 gives the alarm, and notifies that wearer notes the danger of cancer return; The control command of controller 211 passes on the reactor 124 in et al. Ke assembly 1 by the second wireless communication module 214, the startup of the startup of the unlatching of reactor 124 Control protection shell 115 or closedown, control heating module 113 or dormancy, control refrigeration module 114 or dormancy.
External assembly 2 also comprises intelligent mobile terminal equipment 22, and data receiver 21 also comprises the 3rd wireless communication module 215, and tumor marker protein information is sent in intelligent mobile terminal equipment 22 by the 3rd wireless communication module 215 by controller 211.Intelligent mobile terminal equipment 22 pairs of Protein Information carry out remote storage and analysis.
Intelligent mobile terminal equipment 22 can be smart mobile phone, flat board or computer.
Data receiver 12 uses as in vitro accessory.
First wireless communication module 13, second wireless communication module 214, the 3rd wireless communication module 215 adopt Zigbee protocol.
Siren 213 is luminous organs, notifies that wearer notes the danger of cancer return by the mode of luminescence.
Albumen trapping layer 111 is made up of the antibody with blood protein specific binding.
Binding signal inductive layer 112 is made up of array of nanowire transistors.
The combination of albumen trapping layer 111 and binding signal inductive layer 112 is the antibody surface of nano-wire transistor being covered with one deck target protein.
The operation principle of blood protein sensor 11 is: when after the tumor markers-target protein in blood and the antibodies in albumen trapping layer 111, with the electron interaction of the nano-wire transistor top layer movement on binding signal inductive layer 112, change the electric conductivity of nano-wire transistor, before and after being combined by comparison target protein, the difference of the electric conductivity of nano-wire transistor, can know the concentration information of target protein in blood.
Controller 211 timing realize the control to the unlatching of described containment vessel 115 or closedown, the startup to heating module 113 or dormancy control, to the startup of refrigeration module 114 or the control of dormancy.The interval time of continuously adjustabe between 1s to 1800s that control command is assigned, adjustment stepping is 2s.
Heating module 113 causes albumen trapping layer 111 and binding signal inductive layer 112 to be elevated to more than 56 DEG C, this process is instantaneous, and after heating the only extremely short time namely start refrigeration module 114 and complete temperature-fall period, therefore in whole process to the composition in blood without any adverse influence.
Operational approach for the smart machine of cancer return real-time dynamic monitoring:
(1) et al. Ke assembly 1 is implanted in blood;
(2) issue an order to reactor 124 by controller 211 and make it the unlatching of Control protection shell 115, at this moment albumen trapping layer 111 and contacting blood, target protein and antibodies;
(3) after reacting certain hour, issue an order to reactor 124 to make it to control heating module 113 by controller 211 and start, albumen trapping layer 111 and binding signal inductive layer 112 transient temperature is caused to reach 56 DEG C, now, the antigen combined is separated with antibody, afterwards, controller 211 cuts out to reactor 124 Control protection shell 115 of issuing an order, albumen trapping layer 111 and blood are isolated, issue an order to reactor 124 to control refrigeration module 114 with Time Controller 211 and the temperature of albumen trapping layer 111 and binding signal inductive layer 112 is reduced to physiological temp, thus complete one-time detection,
(4) reaction of the information that shown by observation display 212 of the wearer of this smart machine and siren 213 is known and whether be there occurs cancer return danger.
Although illustrate and describe embodiments of the invention, those having ordinary skill in the art will appreciate that: can carry out multiple change, amendment, replacement and modification to these embodiments when not departing from principle of the present invention and aim, scope of the present invention is by claim and equivalents thereof.
Claims (7)
1. for a smart machine for cancer return real-time dynamic monitoring, it is characterized in that, described smart machine comprises et al. Ke assembly (1) and external assembly (2); Described et al. Ke assembly (1) comprises blood protein sensor (11), data processing module (12), the first wireless communication module (13); Described blood protein sensor (11) comprises albumen trapping layer (111), binding signal inductive layer (112), heating module (113), refrigeration module (114), containment vessel (115); Described albumen trapping layer (111) sticks on binding signal inductive layer (112), described containment vessel (115) covers on described albumen trapping layer (111) for described albumen trapping layer (111) and blood separating being opened, described heating module (113) for by the transient heating of described albumen sensor (11) to more than 56 DEG C, described refrigeration module (114) is for being reduced to physiological temp instantaneously by the temperature of the described albumen sensor (11) of having heated; Described data processing module (12) comprises input interface (121), microprocessor (122), output interface (123), reactor (124); Described input interface (121) receives electrochemical signals that described blood protein sensor (11) exports and inputs described microprocessor (122) after it is converted into digital signal, is uploaded to described external assembly (2) after described microprocessor (122) carries out protocol conversion to digital signal by described output interface (123) via described first wireless communication module (13); Described external assembly (2) comprises data receiver (21), and described data receiver (21) comprises controller (211), display (212), siren (213), the second wireless communication module (214); Described controller (211) receives and analyzes the protein signal that described et al. Ke assembly (1) uploads, afterwards Protein Information is sent to the upper display of described display (212), the analysis programme of described controller (211) arranges a threshold value, when this threshold value of horizontal exceeding of albumen, described controller (211) sends instruction to described siren (213), described siren (213) gives the alarm, and notifies that wearer notes the danger of cancer return; The control command of described controller (211) passes on the described reactor (124) in described et al. Ke assembly (1) by described second wireless communication module (214), and described reactor (124) controls the unlatching of described containment vessel (115) or closedown, the startup of the described heating module of control (113) or dormancy, the startup of the described refrigeration module of control (114) or dormancy.
2. smart machine according to claim 1, it is characterized in that, described external assembly (2) also comprises intelligent mobile terminal equipment (22), described data receiver (21) also comprises the 3rd wireless communication module (215), and Protein Information is sent in described intelligent mobile terminal equipment (22) by described 3rd wireless communication module (215) by described controller (211).
3. smart machine according to claim 1 and 2, is characterized in that, described siren (213) is vibrator, notifies that wearer notes the danger of cancer return by the mode of vibration.
4. smart machine according to claim 1 and 2, is characterized in that, described siren (213) is luminous organ, notifies that wearer notes the danger of cancer return by the mode of luminescence.
5. smart machine according to claim 1 and 2, is characterized in that, described blood protein trapping layer (111) is made up of the antibody with blood protein specific binding.
6. smart machine according to claim 1 and 2, is characterized in that, described binding signal inductive layer (112) comprises array of nanowire transistors.
7. smart machine according to claim 1 and 2, it is characterized in that, described first wireless communication module (13), described second wireless communication module (214), described 3rd wireless communication module (215) adopt in Bluetooth protocol or Zigbee protocol any one.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510406730.6A CN104970806B (en) | 2015-07-12 | 2015-07-12 | A kind of smart machine for cancer return real-time dynamic monitoring |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510406730.6A CN104970806B (en) | 2015-07-12 | 2015-07-12 | A kind of smart machine for cancer return real-time dynamic monitoring |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104970806A true CN104970806A (en) | 2015-10-14 |
| CN104970806B CN104970806B (en) | 2017-08-04 |
Family
ID=54268171
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510406730.6A Active CN104970806B (en) | 2015-07-12 | 2015-07-12 | A kind of smart machine for cancer return real-time dynamic monitoring |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104970806B (en) |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000018294A1 (en) * | 1998-09-30 | 2000-04-06 | Sicel Medical Group | Methods, systems, and associated implantable devices for dynamic monitoring of tumors |
| WO2004075032A2 (en) * | 2003-02-19 | 2004-09-02 | Sicel Technologies Inc. | In vivo fluorescence sensors, systems, and related methods operating in conjunction with fluorescent analytes |
| CN201005704Y (en) * | 2007-02-15 | 2008-01-16 | 包头奥普德电子科技有限公司 | Body interplanted biochemistry parameter automatic monitoring system |
| CN101358982A (en) * | 2007-08-01 | 2009-02-04 | 中国科学院电子学研究所 | Saccharification hemoglobin immune sensor based on field effect tube |
| JP2009532692A (en) * | 2006-04-06 | 2009-09-10 | オックスフォード バイオセンサーズ リミテッド | Lipoprotein sensor |
| CN101569559A (en) * | 2008-05-01 | 2009-11-04 | Tyco医疗健康集团 | Medical device package |
| CN102014734A (en) * | 2008-02-26 | 2011-04-13 | 博尔斯特姆斯有限公司 | In vivo micro-invasive investigation device including a metal guide |
| CN104094111A (en) * | 2011-09-22 | 2014-10-08 | 斯隆－凯特林纪念癌症中心 | Detecting ovarian cancer |
| CN204813901U (en) * | 2015-07-12 | 2015-12-02 | 北京泱深生物信息技术有限公司 | A smart machine for monitoring of cancer recurring real time kinematic |
-
2015
- 2015-07-12 CN CN201510406730.6A patent/CN104970806B/en active Active
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000018294A1 (en) * | 1998-09-30 | 2000-04-06 | Sicel Medical Group | Methods, systems, and associated implantable devices for dynamic monitoring of tumors |
| WO2004075032A2 (en) * | 2003-02-19 | 2004-09-02 | Sicel Technologies Inc. | In vivo fluorescence sensors, systems, and related methods operating in conjunction with fluorescent analytes |
| JP2009532692A (en) * | 2006-04-06 | 2009-09-10 | オックスフォード バイオセンサーズ リミテッド | Lipoprotein sensor |
| CN201005704Y (en) * | 2007-02-15 | 2008-01-16 | 包头奥普德电子科技有限公司 | Body interplanted biochemistry parameter automatic monitoring system |
| CN101358982A (en) * | 2007-08-01 | 2009-02-04 | 中国科学院电子学研究所 | Saccharification hemoglobin immune sensor based on field effect tube |
| CN102014734A (en) * | 2008-02-26 | 2011-04-13 | 博尔斯特姆斯有限公司 | In vivo micro-invasive investigation device including a metal guide |
| CN101569559A (en) * | 2008-05-01 | 2009-11-04 | Tyco医疗健康集团 | Medical device package |
| CN104094111A (en) * | 2011-09-22 | 2014-10-08 | 斯隆－凯特林纪念癌症中心 | Detecting ovarian cancer |
| CN204813901U (en) * | 2015-07-12 | 2015-12-02 | 北京泱深生物信息技术有限公司 | A smart machine for monitoring of cancer recurring real time kinematic |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104970806B (en) | 2017-08-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20220233119A1 (en) | Method of adjusting a surgical parameter based on biomarker measurements | |
| US20220101992A1 (en) | Sensor patch and related smart device, systems, and methods | |
| US8489199B2 (en) | Bio-medical unit with power harvesting module and RF communication | |
| TW201247180A (en) | Bio-medical unit system for medication control | |
| Jin et al. | Predicting cardiovascular disease from real-time electrocardiographic monitoring: An adaptive machine learning approach on a cell phone | |
| CN117063243A (en) | Machine learning for improving artificial intelligence algorithm iterations | |
| CN103971157B (en) | Implantable passive ultra-high frequency RFID temperature sensing tag and its cognitive method for animal-breeding | |
| CN205994491U (en) | A kind of remote detecting system of health sign Index | |
| Farajidavar et al. | A miniature bidirectional telemetry system for in vivo gastric slow wave recordings | |
| CN205433706U (en) | Noninvasive glucose monitoring based on finger detects | |
| CN101352343A (en) | Intelligent medicine releasing capsule system for digestive canal and method | |
| CN204813901U (en) | A smart machine for monitoring of cancer recurring real time kinematic | |
| JP2024506501A (en) | Prediction-based system adjustments based on biomarker trends | |
| CN101810473A (en) | Ultra-micro power consumption implanted wireless remote-measuring system | |
| CN104970806A (en) | Smart device used for cancer relapse real-time dynamic monitoring | |
| CN106388995A (en) | Intelligent cooling patch | |
| CN203749415U (en) | Wireless tracking device for digestive tract target objects | |
| CN202998172U (en) | Remote life information monitoring system based on IOT (Internet of Things) | |
| CN204883827U (en) | Tele -medicine detecting system | |
| Cheng et al. | A novel wireless capsule endoscope with JPEG compression engine | |
| CN110488770A (en) | A kind of hospital ward monitoring data acquisition system | |
| Estrela et al. | In-body devices and sensors communication–how implantables, ingestibles, and injectables interact with the internet | |
| Morais et al. | An activation circuit for battery-powered biomedical implantable systems | |
| CN109079807A (en) | A kind of health robot | |
| EP4233063A1 (en) | Contextual transformation of data into aggregated display feeds |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Smart device used for cancer relapse real-time dynamic monitoring Effective date of registration: 20171212 Granted publication date: 20170804 Pledgee: Huaxia Bank Beijing branch Wanliu Limited by Share Ltd Pledgor: Beijing Yang Shen biology information technology company limited Registration number: 2017990001155 |
|
| PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
| PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20181206 Granted publication date: 20170804 Pledgee: Huaxia Bank Beijing branch Wanliu Limited by Share Ltd Pledgor: Beijing Yang Shen biology information technology company limited Registration number: 2017990001155 |
|
| PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Smart device used for cancer relapse real-time dynamic monitoring Effective date of registration: 20181225 Granted publication date: 20170804 Pledgee: Huaxia Bank Beijing branch Wanliu Limited by Share Ltd Pledgor: Beijing Yang Shen biology information technology company limited Registration number: 2018990001252 |
|
| PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
| PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20191206 Granted publication date: 20170804 Pledgee: Huaxia Bank Beijing branch Wanliu Limited by Share Ltd Pledgor: Beijing Yang Shen biology information technology company limited Registration number: 2018990001252 |
|
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20200226 Address after: Room 2503, Qianshan building, building D2, Qingdao International Innovation Park Phase II, No. 1, Keyuan Weiyi Road, Laoshan District, Qingdao, Shandong Province Patentee after: Qingdao Yangshen biomedical Co., Ltd Address before: The court building 1 cubic Beijing No. 100080 Haidian District Shanyuan street 3103 Patentee before: Beijing Yang Shen biology information technology company limited |