CN104906352A - Traditional Chinese medicine liquid for treating deficiency-fire flaring-up type infantile oral ulcer and preparation method thereof - Google Patents

Abstract

The invention discloses a traditional Chinese medicine liquid for treating deficiency-fire flaring-up type infantile oral ulcer and a preparation method thereof. The traditional Chinese medicine liquid is prepared from the raw materials of aloe, rehmannia root, Chinese angelica, root-bark of Chinese wolfberry, dried daylily, snow pear, tree peony bark, dwarf lilyturf tuber, purslane herb, root of common nandina, root of smalltooth gomphostemma, cassia bark, tasmanian bluegum, weeping forsythia capsule, Mongolian snakegourd root, cochinchina momordica, rhizome of tschonosk trillium, datura flower, jack fruit, pine berry, fried licorice root and prepared common monkshood daughter root. The powder is a pure traditional Chinese medicine preparation, is safe and does not have side effects for children to use, can quickly relieve the pain of affected parts of a patient and promote ulcer wound surfaces to heal, can treat both symptoms and root causes of the deficiency-fire flaring-up type infantile oral ulcer, and is significant in curative effect.

Description

A kind ofly treat traditional Chinese medicine liquid of asthenic fire flaring up type oral aphthae in children and preparation method thereof

Technical field

The present invention relates to the field of Chinese medicines, particularly a kind ofly treat traditional Chinese medicine liquid of asthenic fire flaring up type oral aphthae in children and preparation method thereof.

Background technology

There is yellow-white ulcer, pain sialorrhea with places such as gums, tongue body, two cheeks, palates in oral aphthae in children, or the heat that occurs together is feature.If ulcer area is comparatively large, above covers rotten rotten, be called erosion of the oral mucosa; Ulcer only occurs in lip both sides, is called swallow aphtha.Primary disease can occur separately, also can occur together among other diseases.Infant is comparatively common, prognosis bona.If have a delicate constitution, then aphtha occurs repeatedly, and delay is difficult.Modern medicine is thought, there is many pathogenic bacterium and non-pathogenic bacteria in human oral cavity.Under health condition, they and human body remain relative equilibrium, can not cause disease, once resistance of human body weakens, just oral cavity partial inflammation, ulcer can occur.If eat food overheated, really up to the mark to children's, or firmly excessive etc. when cleaning oral cavity of infant and children, all can lesion ports transmucosal and cause inflammation, fester.Children's suffers from respiratory tract infection, heating and by after antibacterial and viral infection, and oral cavity is unclean, and oral mucous membrane is dry, also can cause aphtha.High with underfed children's's sickness rate.Chinese medicine thinks primary disease mainly because retention of heat in the spleen and stomach, and hyperactivity of deficient fire is smoked and burnt dispute thus occur aphthous stomatitis.Common sympton is occur faint yellow or white aphtha face at places such as oral cavity epipharynx, tongue, buccal mucosa, gums, hard hips, single or multiple not etc., edge is neat and have blush, the pain of local, surface, has slight halitosis, excessive saliva and thickness, normal companion's dysphoria, be reluctant to take food, lean body mass, the symptoms such as heating.This disease of Chinese traditional treatment is particular about dialectical treatment, and one will distinguish deficiency and excess.Onset is anxious, and the course of disease is short, oral lesions and pain heavier, there is burning sensation local, or hot person of occurring together, and mostly is excess syndrome; Onset is delayed, and the course of disease is long, and oral lesions and pain comparatively the lighter, mostly is deficiency syndrome.Two will distinguish internal organs.On tongue, the tongue limit person of festering, belong to the heart more; Mouthful buccal, palate, gums bicker is festered is main person, belongs to taste more.In treatment, excess syndrome is controlled with heat-clearing and toxic substances removing; Deficiency syndrome are controlled with nourishing YIN to lower pathogenic fire, conducting fire back to its origin.Oral aphthae in children is divided into wind heat to take advantage of spleen type by the traditional Chinese medical science, type of flaming up of heart-fire and asthenic fire flaring up type three kinds of main Types, wherein, stomatocace of asthenic fire flaring up type is as a kind of common type, disease sees oral lesions, speckle is less, surplus color HUANGBAI(sic), ambient color is light red, Mental fatigue flushed cheeks, fidgets due to deficiency xerostomia, the few tongue of red tongue, thready and rapid pulse, and recurrent exerbation, doctor trained in Western medicine adopts this disease of antibiotic therapy, antibiotic therapy costly, and easily develop immunity to drugs, reduce resistance of human body, comparatively major injury can be caused to the health of child, Chinese traditional treatment spininess is to the comprehensive conditioning human body of pathogenic root, but most method onset is slower, cannot rapid recovery patient suffering, especially child patient very easily produces to this long-term treatment means psychology of conflicting, mismatch treatment, affect the treatment.

Summary of the invention

The present invention improves prior art, in order to overcome the deficiency of existing treatment means, traditional Chinese medicine liquid for the treatment of asthenic fire flaring up type oral aphthae in children and preparation method thereof is provided, this powder is pure Chinese medicinal preparation, child's use safety has no side effect, can rapid recovery patient affected part pain, promotes aphtha wound healing, treating both the principal and secondary aspects of a disease asthenic fire flaring up type oral aphthae in children, evident in efficacy.

To achieve these goals, technical scheme provided by the invention is as follows:

A kind of traditional Chinese medicine liquid for the treatment of asthenic fire flaring up type oral aphthae in children, raw material composition and the parts by weight of making described traditional Chinese medicine liquid are: Aloe 7-10 part, Radix Rehmanniae 4-7 part, Radix Angelicae Sinensis 3-5 part, Cortex Lycii 3-5 part, Flos Hemerocallis 7-10 part, pear 10-15 part, Cortex Moutan 5-7 part, Radix Ophiopogonis 6-8 part, Herba Portulacae 7-12 part, sow grass 3-5 part, Radix Gomphostemmae 4-6 part, Cortex Cinnamomi 2-4 part, Eucalyptus globulus Labill 6-9 part, Fructus Forsythiae 5-8 part, Radix Trichosanthis 3-5 part, Semen Momordicae 3-5 part, Rhizoma Trillii Tschonoskii 6-9 part, Flos Daturae 3-5 part, Fructus Artocarpi Heterophylli 7-10 part, Fructus Ananadis comosi certain kind of berries 8-12 part, Radix Glycyrrhizae Preparata 5-7 part, Radix Aconiti Lateralis Preparata 1-3 part.

Preferably, raw material composition and the parts by weight of making described traditional Chinese medicine liquid are: Aloe 7 parts, Radix Rehmanniae 4 parts, Radix Angelicae Sinensis 3 parts, Cortex Lycii 3 parts, Flos Hemerocallis 7 parts, pear 10 parts, Cortex Moutan 5 parts, Radix Ophiopogonis 6 parts, Herba Portulacae 7 parts, sow grass 3 parts, Radix Gomphostemmae 4 parts, Cortex Cinnamomi 2 parts, Eucalyptus globulus Labill 6 parts, Fructus Forsythiae 5 parts, Radix Trichosanthis 3 parts, Semen Momordicae 3 parts, Rhizoma Trillii Tschonoskii 6 parts, Flos Daturae 3 parts, Fructus Artocarpi Heterophylli 7 parts, the Fructus Ananadis comosi certain kind of berries 8 parts, Radix Glycyrrhizae Preparata 5 parts, Radix Aconiti Lateralis Preparata 1 part.

Preferably, raw material composition and the parts by weight of making described traditional Chinese medicine liquid are: Aloe 10 parts, Radix Rehmanniae 7 parts, Radix Angelicae Sinensis 5 parts, Cortex Lycii 5 parts, Flos Hemerocallis 10 parts, pear 15 parts, Cortex Moutan 7 parts, Radix Ophiopogonis 8 parts, Herba Portulacae 12 parts, sow grass 5 parts, Radix Gomphostemmae 6 parts, Cortex Cinnamomi 4 parts, Eucalyptus globulus Labill 9 parts, Fructus Forsythiae 8 parts, Radix Trichosanthis 5 parts, Semen Momordicae 5 parts, Rhizoma Trillii Tschonoskii 9 parts, Flos Daturae 5 parts, Fructus Artocarpi Heterophylli 10 parts, the Fructus Ananadis comosi certain kind of berries 12 parts, Radix Glycyrrhizae Preparata 7 parts, Radix Aconiti Lateralis Preparata 3 parts.

Preferably, raw material composition and the parts by weight of making described traditional Chinese medicine liquid are: Aloe 9 parts, Radix Rehmanniae 6 parts, Radix Angelicae Sinensis 4 parts, Cortex Lycii 4 parts, Flos Hemerocallis 8 parts, pear 12 parts, Cortex Moutan 6 parts, Radix Ophiopogonis 7 parts, Herba Portulacae 10 parts, sow grass 4 parts, Radix Gomphostemmae 5 parts, Cortex Cinnamomi 3 parts, Eucalyptus globulus Labill 7 parts, Fructus Forsythiae 7 parts, Radix Trichosanthis 4 parts, Semen Momordicae 4 parts, Rhizoma Trillii Tschonoskii 7 parts, Flos Daturae 4 parts, Fructus Artocarpi Heterophylli 8 parts, the Fructus Ananadis comosi certain kind of berries 10 parts, Radix Glycyrrhizae Preparata 6 parts, Radix Aconiti Lateralis Preparata 2 parts.

The present invention is in order to treat asthenic fire flaring up type oral aphthae in children, take nourishing YIN to lower pathogenic fire, guiding fire to origin, putrefaction-removing granulation-promoting, method that antiinflammatory relieves the pain, while this disease of etiological treatment for hyperactivity of deficient fire, effective reduction of patient affected part pain, alleviate patient suffering fast, avoid child patient to produce psychology of conflicting, guarantee therapeutic effect.According to Chinese medical theory determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, screen raw material of Chinese medicine by great many of experiments, refining agent method, make each efficacy of drugs produce synergism, thus reach the effect for the treatment of both the principal and secondary aspects of a disease.In the crude drug chosen: Aloe: the cool liver of heat clearing away, rush down lower parasite killing, hydroxy kind contained by it, anthraquinone derivatives tools as many in organic active ingredients such as aloe-emodins kill, press down skin surface bacterial action, and complex polysaccharide and organic acid are natural moisturizing elements, can the moisture lost in skin be supplemented, repair Skin Cell; Radix Rehmanniae: sweetness and bitterness, cool in nature, clearing away heat and promoting production of body fluid YIN nourishing, nourishes blood, and controls fever due to yin deficiency, quenches one's thirst, and spits blood, epistaxis, metrorrhagia, menoxenia, frequent fetal movement, and the moon hinders constipation; Radix Angelicae Sinensis: sweet in the mouth, temperature, enriches blood, invigorates blood circulation, menstruction regulating and pain relieving, moisturize laxation, all cards of main blood deficiency, menoxenia, amenorrhea, dysmenorrhea, and lump in the abdomen knot is poly-, metrorrhagia, asthenia cold abdominalgia, flaccidity syndrome and arthralgia syndrome, numbness of the skin, dryness of the intestine dyschezia, heavy after bloody dysentery, ulcer sores, injury from falling down; Cortex Lycii: cold in nature, sweet in the mouth, removing heat from blood removes and steams, lung heat clearing pathogenic fire reducing.For deficiency of YIN hectic fever, hectic fever due to YIN-deficiency night sweat, cough due to lung-heat, spitting of blood, epistaxis.Interior-heat is quenched one's thirst; Flos Hemerocallis: call Hemerocallis fulva L., forget melancholy grass, Radix hemerocalis plicatae, dry products claims Flos Hemerocallis, containing protein, carbohydrate, calcium, phosphorus, ferrum, etc. multiple nutritional components, wherein the content of ferrum is about 20 times of Herba Spinaciae, and is rich in ascorbic acid. have heat clearing away, diuresis, calm the nerves, Fructus Alpiniae Oxyphyllae, the effect such as improving eyesight; Pear: clearing away heart-fire and moistening the lung, heat clearing away expectorant; Cortex Moutan: bitter, pungent, is slightly cold, GUIXIN, liver, kidney channel, clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling, for maculae caused by violent heat pathogen, and hematemesis and epistaxis, night fever abating at dawn, lossless hectic fever due to YIN-deficiency, amenorrhea dysmenorrhea, carbuncle sore tumefacting virus, falls and flutters the pain of injury; Radix Ophiopogonis: sweet, micro-hardship, is slightly cold.GUIXIN, lung, stomach warp.YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire, and for dryness of the lung dry cough, deficiency of YIN consumptive disease is coughed, sore throat pharyngalgia, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, vexed insomnia, dryness of the intestine constipation; Herba Portulacae: cold in nature, sweet in the mouth acid; Enter the heart, liver, spleen, large intestine channel.Have that removing dampness is antipruritic, clearing heat for detumescence, heat-clearing and toxic substances removing, diuretic dries, loose blood detumescence, dust-collection sterilization, anti-inflammatory analgetic, the effect of hemostasis removing heat from blood.Herba Portulacae has stronger inhibitory action to dysentery bacterium, Bacillus typhi and escherichia coli, can be used for the auxiliary treatment of various inflammation, have the title of " natural antibiotics ", simultaneously Herba Portulacae is also rich in vitamin C, and vitamin C has good antioxidation can whitening nourishes rough skin; Sow grass: bitter in the mouth, cold in nature, removing damp-heat, detoxicating and resolving stagnation of pathogens, relieving cough and resolving phlegm, main jaundice due to damp-heat, carbuncle sore tumefacting virus, scrofula, phlegm-heat cough, epilepsy; Radix Gomphostemmae: bitter in the mouth, cool in nature, heat-clearing and toxic substances removing, relieving cough and resolving phlegm, antiinflammatory diuresis, controls pneumonia, tracheobronchitis, cough with copious phlegm, urinary tract infection, cystitis, oedema due to nephritis, lithangiuria; Cortex Cinnamomi: pungent, sweet, hot greatly, slightly poisonous, enter liver,spleen,kidney warp, Materia Medica of Decoction cloud: " Cortex Cinnamomi enters kidney meridian, Taiyin channels blood system, mends the deficiency of the gate of vitality, boosting source of fire for eliminating abundance of yin." " book on Chinese herbal medicine is looked for the truth " cloud: " the pure sun of cinnamic odor, pungent sweet large heat, straight Liver and kidney blood system thoroughly, the large benefit gate of vitality is mutually fiery, Yiyang Zhi Yin, covers because abnormal smells from the patient is sweet pungent, its color purple is red, has the energy of inspiring QI and blood, the pure sun of gonosome, have and recruit the power that lures of guiding, this bromhidrosis lightly floats, can the high benefit gate of vitality, reactivation is altered and is reached table, and Yi Tongying defends, but damage of essence insufficiency of blood, liver-yang hyperactivity fire plays person, must guard against." Cortex Cinnamomi is for " guiding fire to origin ", treatment deficiency of kidney-YIN, the outer deficiency-heat syndrome floated of empty sun, normal and drugs for nourishing yin share, said as " collection of prescriptions with notes ": " LIUWEI DIHUANG WAN adds Cortex Cinnamomi name seven taste Dihuang Wan, can draw the fire of unrooted, falls and return unit." Cortex Cinnamomi coordinates the agent of YIN nourishing to control deficiency-heat syndrome, be because of pericardium mutually fire invest the gate of vitality, man's store essential substances, female is to be born of the same parents.If fire is without scorching in institute's supplemental provisions, though large hot excessive thirst, cheilosis, arteries and veins is shown in loud heavy by faint, control with the Cortex Cinnamomi that sweet temperature is hot a small amount of, treating heat syndrome with drugs of hot nature, treating hot natured symptoms(pseudomorph)with hot natured medicine, guiding fire to origin, its sun short invests the moon, YIN and YANG in a relative equilibrium, life activities being normally maintained, notice that dosage is unsuitable excessive, due to the pungent sweet large heat of Cortex Cinnamomi, the pure sun of abnormal smells from the patient, its gas is descending, boosting source of fire for eliminating abundance of yin, large YANG invigorating gas, be applicable to the fiery not enough person of part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels life, for guiding fire to origin to fall deficiency-heat, must protect approximately with the drugs for nourishing yin side of share, once excessive very easily supporing yang consumption is cloudy, sun is vulcanized greatly if let alone, pungent faling apart is walked to alter, then cloudy benefit is empty, sun benefit is high, harmful and unhelpful, Eucalyptus globulus Labill: micro-pungent, the micro-hardship of taste, property is put down, and dispelling wind is antipyretic, inhibiting bacteria and diminishing inflammation, anticorrosion antipruritic.For preventing influenza, epidemic cerebrospinal meningitis, control upper respiratory tract infection, pharyngolaryngitis, bronchitis, pneumonia, Acute and chronic pyelonephritis, enteritis, dysentery, filaricide, burn and scald is controlled in external, cellulitis, mastitis, furuncle and phyma, erysipelas, paddy-field dermatitis, skin eczema, tinea pedis, skin degerming; Fructus Forsythiae: heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, dispelling wind and heat pathogens, modern medicine study confirms, Fructus Forsythiae concentrated decotion has antibacterial action in vitro, can suppress Bacillus typhi, Salmonella paratyphi, escherichia coli, dysentery bacterium, diphtheria corynebacterium and vibrio cholera, staphylococcus, streptococcus etc.; Radix Trichosanthis: clearing away heat and promoting production of body fluid, detumescence and apocenosis, for calentura excessive thirst, lung-heat type cough, interior-heat is quenched one's thirst, sore swollen toxin; Semen Momordicae: dispersing swelling and dissipating binds, removing toxic substances, chases after wind pain relieving, main carbuncle, furuncle, innominate toxic swelling, hemorrhoid, tinea skin ulcer, acne, silent black, mastitis, tuberculous lymphadenitis, dysentery, rheumatic arthralgia, the contracture of muscle arteries and veins, gingival swelling and pain; Rhizoma Trillii Tschonoskii: sweet in the mouth is micro-pungent, warm in nature, hemostasis, analgesia, granulation promoting, except rheumatism, detumescence poison, controls traumatic hemorrhage, various lumbago, impairment caused by overstrain, traumatic injury, innominate toxic swelling; Flos Daturae: smooth-going cough-relieving, narcotic analgesic, spasmolytic is only jerked; Fructus Artocarpi Heterophylli: have quench the thirst, lactogenesis, invigorating the spleen and replenishing QI effect, local blood circulation can be improved, to bronchitis, bronchial asthma, acute pneumonia, pharyngolaryngitis, retinitis, mastitis, puerperal engorgement of breasts, postpartum thrombophlebitis, arthritis, periarthritis, cellulitis, the disease such as ulcus cruris be all effective in cure, research finds that Fructus Artocarpi Heterophylli has antioxidation, antibacterial, antiinflammatory, adjunct antineoplastic, check melanin generate and the modern medicinal efficacy such as auxiliary hyperglycemic; The Fructus Ananadis comosi certain kind of berries: containing a kind of material being " Fructus Ananadis comosi proteinase ", Fructus Ananadis comosi proteinase can dissolve the effect of fibrin and the blood clot blocked in tissue, the blood circulation of local can be improved, diminish inflammation and edema, it is the plant that tanin content enriches, and the adsorbable absorption with stoping carcinogenic chemical, has protective effect on cancer risk in vivo, the carotene that it contains is the important substance of synthetic vitamin A, has improving eyesight nourishing the liver effect; Radix Glycyrrhizae Preparata: containing number of chemical compositions such as glycyrrhizin, enoxolone, Angelica Polysaccharide, there is antiinflammatory and anti-allergy action, scalable body's immunity, antitumor and analgesic effect, therefore the primary efficacy of Radix Glycyrrhizae Preparata is and middle emergency, lung moistening, removing toxic substances, coordinating the actions of various ingredients in a prescription; Radix Aconiti Lateralis Preparata: pungent, sweet is warm greatly; Poisonous.GUIXIN, kidney, spleen channel." book on Chinese herbal medicine converges and says ": Radix Aconiti Lateralis Preparata, recuperating depleted YANG gas, loose YIN-cold, by cold phlegm, the violent medicine of getting round by bribery also, all sick insufficiency of kidney-YANG, depletion fire syndrome going up, discomfort in the throat, anorexia, more notably, Radix Aconiti Lateralis Preparata is gate of vitality's principal agent to the cold medicine of clothes, can enter Qi Ku cave and recruit it, conducting fire back to its origin, then the fire swum puts out certainly, the time of all genus yang deficiency negative electrodes, lung kidney without heat syndrome person, clothes had dead distinguished service.

The invention also discloses a kind of preparation method for the treatment of the traditional Chinese medicine liquid of asthenic fire flaring up type oral aphthae in children, comprise the following steps:

(1) Radix Rehmanniae, Radix Angelicae Sinensis, Cortex Lycii, Flos Hemerocallis, Cortex Moutan, Radix Ophiopogonis, Cortex Cinnamomi, Eucalyptus globulus Labill, Fructus Forsythiae, Radix Trichosanthis, Semen Momordicae, Rhizoma Trillii Tschonoskii, Flos Daturae, Radix Glycyrrhizae Preparata, Radix Aconiti Lateralis Preparata are pulverized, and cross 80 mesh sieves and obtain mixed-powder, for subsequent use;

(2) step (1) gained mixed-powder adds the distilled water immersion 1 hour of gross mass multiple 6 times, slow fire boiling 1 hour, and cross 500 order drainage screens after decocting, gained filtrate is dried in the air cool for subsequent use to room temperature;

(3) Aloe, pear, Fructus Artocarpi Heterophylli enucleation, Fructus Ananadis comosi certain kind of berries stalk, mix with Herba Portulacae, Radix Gomphostemmae, sow grass and clean, add after step (2) gained filtrate is squeezed the juice and leave standstill 2 hours, cross 1000 filter screen filtration, gained filter vacuum simmer down to original volume 10% concentrated solution, thickening temperature is lower than 45 DEG C;

(4) after the concentrated solution of step (3) gained being frozen into solid, be placed in vacuum freeze drier lyophilization, baking temperature is-25 ~-20 DEG C, pressure is-0.09 ~-0.08Mpa, gained drying solid super micron mill is pulverized, and gained powder crosses the traditional Chinese medicine liquid that namely 1000 mesh sieves obtain treatment asthenic fire flaring up type oral aphthae in children.

The using method of this traditional Chinese medicine liquid: after cleaning affected part with pure water, then dip this traditional Chinese medicine liquid wiping affected part with disinfecting cotton swab, 3-4 time on the one.

Beneficial effect of the present invention is: the invention provides a kind of traditional Chinese medicine liquid for the treatment of asthenic fire flaring up type oral aphthae in children, take nourishing YIN to lower pathogenic fire, guiding fire to origin, putrefaction-removing granulation-promoting, method that antiinflammatory relieves the pain, while for this disease of etiological treatment, effective reduction of patient affected part pain, promote ulcer surface healing, alleviate patient suffering fast, avoid child patient to produce psychology of conflicting, guarantee therapeutic effect, specifically:

(1) this medicinal liquid adopts pure Chinese medicinal preparation, selected medical material compatibility is suitable, in all medicines, Aloe, Radix Rehmanniae are monarch drug, for disease and the cause of disease of asthenic fire flaring up type oral aphthae in children, the effect that a nourishing YIN to lower pathogenic fire, putrefaction-removing granulation-promoting, antiinflammatory relieve the pain, this disease for the treatment of both the principal and secondary aspects of a disease, rapid recovery affected part pain, reduces patient suffering, Radix Angelicae Sinensis, Cortex Lycii, Flos Hemerocallis, pear, Cortex Moutan, Radix Ophiopogonis, Herba Portulacae, sow grass, Radix Gomphostemmae, Cortex Cinnamomi, Eucalyptus globulus Labill, Fructus Forsythiae, Radix Trichosanthis, Semen Momordicae, Rhizoma Trillii Tschonoskii, Flos Daturae, Radix Aconiti Lateralis Preparata is ministerial drug, wherein, Herba Portulacae, Radix Gomphostemmae, Fructus Forsythiae, Semen Momordicae, Rhizoma Trillii Tschonoskii, Flos Daturae, Eucalyptus globulus Labill can the effect that relieves the pain of gain monarch drug antiinflammatory, directly act on ulcer surface, effective antimicrobial therapy aphtha, the swollen pain in rapid recovery affected part, alleviate patient suffering, Radix Angelicae Sinensis, Cortex Lycii, Flos Hemerocallis, pear, Radix Ophiopogonis, Cortex Moutan, Herba Portulacae, sow grass, Radix Gomphostemmae, Fructus Forsythiae, Radix Trichosanthis, Eucalyptus globulus Labill can the effect of gain monarch drug nourishing YIN to lower pathogenic fire, for the etiological treatment aphtha of hyperactivity of deficient fire, Cortex Cinnamomi, Radix Aconiti Lateralis Preparata is the product of warming YANG, with YIN nourishing class medicine with using, the effect of guiding fire to origin can be played, better treatment asthenic fire flaring up type oral aphthae in children, Herba Portulacae, Rhizoma Trillii Tschonoskii can the effect of gain monarch drug Aloe putrefaction-removing granulation-promoting, affected part ulcer surface healing can be promoted, Fructus Artocarpi Heterophylli and the Fructus Ananadis comosi certain kind of berries are assistant, and Fructus Artocarpi Heterophylli and the Fructus Ananadis comosi certain kind of berries not only can strengthen the effect of the anti-inflammatory analgetic of monarch drug and ministerial drug, also have the effect improving local blood circulation simultaneously, can increase the absorption of other drug effective ingredient, promote that the drug effect of other all medicines plays, Radix Glycyrrhizae Preparata is for drawing, and warming spleen and stomach for dispelling cold, coordinating the actions of various ingredients in a prescription, better treats this disease.This traditional Chinese medicine liquid adopts modern advanced medical pharmaceutical technology to make, and has treating both the principal and secondary aspects of a disease rapid-action, can effective reduction of patient misery, and the remarkable advantage of safe without toxic side effect, is adapted to the treatment to asthenic fire flaring up type oral aphthae in children.Especially suitable child uses, and effectively prevent the drug resistance and toxic and side effects problem that adopt this disease of antibiotic medication to produce.

(2) this traditional Chinese medicine liquid have employed the Fructus Artocarpi Heterophylli and the Fructus Ananadis comosi certain kind of berries that can improve and promote local blood circulation as adjuvant drug in the choosing of crude drug, by improving the sanguimotor method in coating position, accelerate local blood velocity, promote Transdermal absorption, make the effective ingredient of Transdermal absorption can arrive affected part with blood flow fast, promote curative effect of medication, Fructus Artocarpi Heterophylli and the Fructus Ananadis comosi certain kind of berries are as food grade materials, compared to conventional Percutaneous absorption enhancer as azone compounds, alcohol compound and dimethyl sulfoxide and homologue thereof, its to the stimulation of human body and toxic and side effects less, especially for child, use safer.

(3) this traditional Chinese medicine liquid is in preparation process, crude drug is pulverized in advance and decocts again, add the contact area of crude drug and water, advantageously in the extraction of effective ingredient, crude drug can be made full use of, gained drug extract is dried in the air and squeezes the juice cool mixing with Fructus Artocarpi Heterophylli, the Fructus Ananadis comosi certain kind of berries etc. again to room temperature, effective ingredient in the medicines such as cold extraction Fructus Artocarpi Heterophylli, the vitamins and other nutritious components in Fructus Artocarpi Heterophylli and effective ingredient effectively can be avoided in leaching process to be subject to high temperature, better to ensure drug effect.

Detailed description of the invention

According to following embodiment, the present invention may be better understood.But those skilled in the art will readily understand, concrete material proportion, process conditions and result thereof described by embodiment only should can not limit the present invention described in detail in claims yet for illustration of the present invention.

Embodiment 1

Treat a traditional Chinese medicine liquid for asthenic fire flaring up type oral aphthae in children, raw material composition and the parts by weight of making described traditional Chinese medicine liquid are: Aloe 7 parts, Radix Rehmanniae 4 parts, Radix Angelicae Sinensis 3 parts, Cortex Lycii 3 parts, Flos Hemerocallis 7 parts, pear 10 parts, Cortex Moutan 5 parts, Radix Ophiopogonis 6 parts, Herba Portulacae 7 parts, sow grass 3 parts, Radix Gomphostemmae 4 parts, Cortex Cinnamomi 2 parts, Eucalyptus globulus Labill 6 parts, Fructus Forsythiae 5 parts, Radix Trichosanthis 3 parts, Semen Momordicae 3 parts, Rhizoma Trillii Tschonoskii 6 parts, Flos Daturae 3 parts, Fructus Artocarpi Heterophylli 7 parts, the Fructus Ananadis comosi certain kind of berries 8 parts, Radix Glycyrrhizae Preparata 5 parts, Radix Aconiti Lateralis Preparata 1 part.

The preparation method of traditional Chinese medicine liquid, comprises the following steps:

(1) Radix Rehmanniae, Radix Angelicae Sinensis, Cortex Lycii, Flos Hemerocallis, Cortex Moutan, Radix Ophiopogonis, Cortex Cinnamomi, Eucalyptus globulus Labill, Fructus Forsythiae, Radix Trichosanthis, Semen Momordicae, Rhizoma Trillii Tschonoskii, Flos Daturae, Radix Glycyrrhizae Preparata, Radix Aconiti Lateralis Preparata are pulverized, and cross 80 mesh sieves and obtain mixed-powder, for subsequent use;

(2) step (1) gained mixed-powder adds the distilled water immersion 1 hour of gross mass multiple 6 times, slow fire boiling 1 hour, and cross 500 order drainage screens after decocting, gained filtrate is dried in the air cool for subsequent use to room temperature;

(3) Aloe, pear, Fructus Artocarpi Heterophylli enucleation, Fructus Ananadis comosi certain kind of berries stalk, mix with Herba Portulacae, Radix Gomphostemmae, sow grass and clean, add after step (2) gained filtrate is squeezed the juice and leave standstill 2 hours, cross 1000 filter screen filtration, gained filtrate is the traditional Chinese medicine liquid for the treatment of asthenic fire flaring up type oral aphthae in children.

The using method of this traditional Chinese medicine liquid: after cleaning affected part with pure water, then dip this traditional Chinese medicine liquid wiping affected part with disinfecting cotton swab, 3-4 time on the one.

Embodiment 2

Treat a traditional Chinese medicine liquid for asthenic fire flaring up type oral aphthae in children, raw material composition and the parts by weight of making described traditional Chinese medicine liquid are: Aloe 9 parts, Radix Rehmanniae 6 parts, Radix Angelicae Sinensis 4 parts, Cortex Lycii 4 parts, Flos Hemerocallis 8 parts, pear 12 parts, Cortex Moutan 6 parts, Radix Ophiopogonis 7 parts, Herba Portulacae 10 parts, sow grass 4 parts, Radix Gomphostemmae 5 parts, Cortex Cinnamomi 3 parts, Eucalyptus globulus Labill 7 parts, Fructus Forsythiae 7 parts, Radix Trichosanthis 4 parts, Semen Momordicae 4 parts, Rhizoma Trillii Tschonoskii 7 parts, Flos Daturae 4 parts, Fructus Artocarpi Heterophylli 8 parts, the Fructus Ananadis comosi certain kind of berries 10 parts, Radix Glycyrrhizae Preparata 6 parts, Radix Aconiti Lateralis Preparata 2 parts.

The preparation method of described traditional Chinese medicine liquid is identical with embodiment 1 with using method.

Embodiment 3

Treat a traditional Chinese medicine liquid for asthenic fire flaring up type oral aphthae in children, raw material composition and the parts by weight of making described traditional Chinese medicine liquid are: Aloe 10 parts, Radix Rehmanniae 7 parts, Radix Angelicae Sinensis 5 parts, Cortex Lycii 5 parts, Flos Hemerocallis 10 parts, pear 15 parts, Cortex Moutan 7 parts, Radix Ophiopogonis 8 parts, Herba Portulacae 12 parts, sow grass 5 parts, Radix Gomphostemmae 6 parts, Cortex Cinnamomi 4 parts, Eucalyptus globulus Labill 9 parts, Fructus Forsythiae 8 parts, Radix Trichosanthis 5 parts, Semen Momordicae 5 parts, Rhizoma Trillii Tschonoskii 9 parts, Flos Daturae 5 parts, Fructus Artocarpi Heterophylli 10 parts, the Fructus Ananadis comosi certain kind of berries 12 parts, Radix Glycyrrhizae Preparata 7 parts, Radix Aconiti Lateralis Preparata 3 parts.

The preparation method of described traditional Chinese medicine liquid is identical with embodiment 1 with using method.

Embodiment 4 toxicity test

To this traditional Chinese medicine liquid " acute oral toxicity once limit the quantity test method(s) " experiment, choose healthy adult mice, body weight 18-22g, 60, male and female half and half, 10% of average weight must not be exceeded with sex mice mesosome heavy phase difference.Experiment starts fasting in front 16h, then 3 groups are equally divided into arbitrarily with the administration of per os administration by gavage to adult mice, give the traditional Chinese medicine liquid of embodiment 1 to 3 respectively, gavage metering is with 100mg/Kg weighing machine, then fasting 3 days is continued, test mice overall health of patients, diet, drinking-water, body weight increase all normal, do not occur trembling, twitch, sialorrhea, diarrhoea, obviously intoxicating phenomenon and the phenomena of mortality such as drowsiness, stupor, place's post mortem Non Apparent Abnormality, judges that this medicine is to the nontoxic level in the true border of adult mice acute oral toxicity.

Embodiment 5 clinical trial:

Random selecting 240 wind heat take advantage of spleen type oral aphthae in children patient to carry out clinical trial, patient age 2 ~ 6 years old, average 3.5 years old, patient is divided into 4 groups at random, be respectively matched group, experiment A group, experiment B group, experiment C group, medication: after cleaning affected part with pure water, then dip this traditional Chinese medicine liquid wiping affected part with disinfecting cotton swab, 3-4 time on the one.Each group of administrations is as follows:

Control group A: give to contrast traditional Chinese medicine liquid;

Experiment A group: the traditional Chinese medicine liquid giving the embodiment of the present invention 1;

Experiment B group: the traditional Chinese medicine liquid giving the embodiment of the present invention 2;

Experiment C group: the traditional Chinese medicine liquid giving the embodiment of the present invention 3;

Wherein, raw material composition and the parts by weight of making matched group traditional Chinese medicine liquid are: Aloe 7 parts, Radix Rehmanniae 4 parts, Radix Angelicae Sinensis 3 parts, Cortex Lycii 3 parts, Flos Hemerocallis 7 parts, pear 10 parts, Cortex Moutan 5 parts, Radix Ophiopogonis 6 parts, Herba Portulacae 7 parts, sow grass 3 parts, Radix Gomphostemmae 4 parts, Cortex Cinnamomi 2 parts, Eucalyptus globulus Labill 6 parts, Fructus Forsythiae 5 parts, Radix Trichosanthis 3 parts, Semen Momordicae 3 parts, Rhizoma Trillii Tschonoskii 6 parts, Flos Daturae 3 parts, Radix Glycyrrhizae Preparata 5 parts, Radix Aconiti Lateralis Preparata 1 part.

The preparation method of this traditional Chinese medicine liquid, comprises the following steps:

(1) Radix Rehmanniae, Radix Angelicae Sinensis, Cortex Lycii, Flos Hemerocallis, Cortex Moutan, Radix Ophiopogonis, Cortex Cinnamomi, Eucalyptus globulus Labill, Fructus Forsythiae, Radix Trichosanthis, Semen Momordicae, Rhizoma Trillii Tschonoskii, Flos Daturae, Radix Glycyrrhizae Preparata, Radix Aconiti Lateralis Preparata are pulverized, and cross 80 mesh sieves and obtain mixed-powder, for subsequent use;

(2) step (1) gained mixed-powder adds the distilled water immersion 1 hour of gross mass multiple 6 times, slow fire boiling 1 hour, and cross 500 order drainage screens after decocting, gained filtrate is dried in the air cool for subsequent use to room temperature;

(3) Aloe, pear, Herba Portulacae, Radix Gomphostemmae, the mixing of sow grass are cleaned, and add after step (2) gained filtrate is squeezed the juice and leave standstill 2 hours, cross 1000 filter screen filtration, gained filtrate is the traditional Chinese medicine liquid of matched group.

Therapeutic process was a course for the treatment of with 3 days, and through the treatment of a course for the treatment of, evaluate the curative effect of each group of traditional Chinese medicine liquid, the standard of curative effect evaluation is:

Cure: all diseases of patient complete disappearance, rear three months without recurrence;

Take a turn for the better: patient condition is obviously alleviated, or disease disappears completely, but recur in three months;

Invalid: disease is unchanged or increase the weight of.

Statistical result is as follows:

	Matched group	Experiment A group	Experiment B group	Experiment C group
					Cure (/ example)	10	15	17	17
Take a turn for the better (/ example)	36	37	38	40
					Invalid (/ example)	14	8	5	3
Effective percentage (%)	76.67	86.67	91.67	95

Clinical exemplary embodiments:

1, money, 3 years old, female, visible polylith yellow-white ulcer surface in patient oral cavity is pale red around ulcer surface, affected part hurt like hell, the few tongue of patient's fidgets due to deficiency xerostomia, red tongue, uses the traditional Chinese medicine liquid treatment of the embodiment of the present invention 1, when secondary use pain symptom i.e. alleviation to some extent, after the course for the treatment of, pain symptom obviously alleviates, and ulcer surface starts healing, two the course for the treatment of symptom all disappear, ulcer all healed, disease disappears completely, without recurrence in drug withdrawal three months.

2, Jiang, 2 years old, man, visible one piece of larger yellow-white ulcer surface in patient oral cavity, the few tongue of red tongue, hurt like hell, once treat by the method for outer painting Kouchuang powder for curing aphthosis, more afterwards recurrent exerbation.Use the traditional Chinese medicine liquid treatment of the embodiment of the present invention 2, treatment affected part pain symptom on the same day is obviously alleviated, and after the course for the treatment of, symptom all disappears, ulcer all healed, and disease disappears completely, without recurrence in drug withdrawal three months.

3, Zhang, 5 years old, man, visible bulk yellow-white ulcer surface in oral cavity is pale red around ulcer surface, affected part pain, the few tongue of red tongue, Mental fatigue flushed cheeks, the conscious xerostomia fidgets due to deficiency of patient, use the traditional Chinese medicine liquid treatment of the embodiment of the present invention 3, treatment pain symptom on the same day is alleviated to some extent, after the course for the treatment of, ulcer surface heals substantially, and pain alleviates, use three courses for the treatment of, ulcer surface heals completely, and whole disease disappears, without recurrence in drug withdrawal three months.

All patients during medication all without bad reflection, experimental result shows, the traditional Chinese medicine liquid for the treatment of asthenic fire flaring up type oral aphthae in children of the present invention, can rapid recovery affected part pain, wound healing, evident in efficacy, safe and effective healing can treat scorching type oral aphthae in children in deficiency-heat, without recurrence after curing, it is desirable medicine.

Above embodiment is only for illustrating technical conceive of the present invention and feature; its object is to allow person skilled in the art understand content of the present invention and to be implemented; can not limit the scope of the invention with this; all equivalences done according to spirit of the present invention change or modify, and all should be encompassed in protection scope of the present invention.

Claims (5)

1. treat the traditional Chinese medicine liquid of asthenic fire flaring up type oral aphthae in children for one kind, it is characterized in that: raw material composition and the parts by weight of making described traditional Chinese medicine liquid are: Aloe 7-10 part, Radix Rehmanniae 4-7 part, Radix Angelicae Sinensis 3-5 part, Cortex Lycii 3-5 part, Flos Hemerocallis 7-10 part, pear 10-15 part, Cortex Moutan 5-7 part, Radix Ophiopogonis 6-8 part, Herba Portulacae 7-12 part, sow grass 3-5 part, Radix Gomphostemmae 4-6 part, Cortex Cinnamomi 2-4 part, Eucalyptus globulus Labill 6-9 part, Fructus Forsythiae 5-8 part, Radix Trichosanthis 3-5 part, Semen Momordicae 3-5 part, Rhizoma Trillii Tschonoskii 6-9 part, Flos Daturae 3-5 part, Fructus Artocarpi Heterophylli 7-10 part, Fructus Ananadis comosi certain kind of berries 8-12 part, Radix Glycyrrhizae Preparata 5-7 part, Radix Aconiti Lateralis Preparata 1-3 part.

2. a kind of traditional Chinese medicine liquid for the treatment of asthenic fire flaring up type oral aphthae in children as claimed in claim 1, is characterized in that: raw material composition and the parts by weight of making described traditional Chinese medicine liquid are: Aloe 7 parts, Radix Rehmanniae 4 parts, Radix Angelicae Sinensis 3 parts, Cortex Lycii 3 parts, Flos Hemerocallis 7 parts, pear 10 parts, Cortex Moutan 5 parts, Radix Ophiopogonis 6 parts, Herba Portulacae 7 parts, sow grass 3 parts, Radix Gomphostemmae 4 parts, Cortex Cinnamomi 2 parts, Eucalyptus globulus Labill 6 parts, Fructus Forsythiae 5 parts, Radix Trichosanthis 3 parts, Semen Momordicae 3 parts, Rhizoma Trillii Tschonoskii 6 parts, Flos Daturae 3 parts, Fructus Artocarpi Heterophylli 7 parts, the Fructus Ananadis comosi certain kind of berries 8 parts, Radix Glycyrrhizae Preparata 5 parts, Radix Aconiti Lateralis Preparata 1 part.

3. a kind of traditional Chinese medicine liquid for the treatment of asthenic fire flaring up type oral aphthae in children as claimed in claim 1, is characterized in that: raw material composition and the parts by weight of making described traditional Chinese medicine liquid are: Aloe 10 parts, Radix Rehmanniae 7 parts, Radix Angelicae Sinensis 5 parts, Cortex Lycii 5 parts, Flos Hemerocallis 10 parts, pear 15 parts, Cortex Moutan 7 parts, Radix Ophiopogonis 8 parts, Herba Portulacae 12 parts, sow grass 5 parts, Radix Gomphostemmae 6 parts, Cortex Cinnamomi 4 parts, Eucalyptus globulus Labill 9 parts, Fructus Forsythiae 8 parts, Radix Trichosanthis 5 parts, Semen Momordicae 5 parts, Rhizoma Trillii Tschonoskii 9 parts, Flos Daturae 5 parts, Fructus Artocarpi Heterophylli 10 parts, the Fructus Ananadis comosi certain kind of berries 12 parts, Radix Glycyrrhizae Preparata 7 parts, Radix Aconiti Lateralis Preparata 3 parts.

4. a kind of traditional Chinese medicine liquid for the treatment of asthenic fire flaring up type oral aphthae in children as claimed in claim 1, is characterized in that: raw material composition and the parts by weight of making described traditional Chinese medicine liquid are: Aloe 9 parts, Radix Rehmanniae 6 parts, Radix Angelicae Sinensis 4 parts, Cortex Lycii 4 parts, Flos Hemerocallis 8 parts, pear 12 parts, Cortex Moutan 6 parts, Radix Ophiopogonis 7 parts, Herba Portulacae 10 parts, sow grass 4 parts, Radix Gomphostemmae 5 parts, Cortex Cinnamomi 3 parts, Eucalyptus globulus Labill 7 parts, Fructus Forsythiae 7 parts, Radix Trichosanthis 4 parts, Semen Momordicae 4 parts, Rhizoma Trillii Tschonoskii 7 parts, Flos Daturae 4 parts, Fructus Artocarpi Heterophylli 8 parts, the Fructus Ananadis comosi certain kind of berries 10 parts, Radix Glycyrrhizae Preparata 6 parts, Radix Aconiti Lateralis Preparata 2 parts.

5. a kind of preparation method for the treatment of the traditional Chinese medicine liquid of asthenic fire flaring up type oral aphthae in children as described in Claims 1-4, is characterized in that: comprise the following steps:

(1) Radix Rehmanniae, Radix Angelicae Sinensis, Cortex Lycii, Flos Hemerocallis, Cortex Moutan, Radix Ophiopogonis, Cortex Cinnamomi, Eucalyptus globulus Labill, Fructus Forsythiae, Radix Trichosanthis, Semen Momordicae, Rhizoma Trillii Tschonoskii, Flos Daturae, Radix Glycyrrhizae Preparata, Radix Aconiti Lateralis Preparata are pulverized, and cross 80 mesh sieves and obtain mixed-powder, for subsequent use;

(2) step (1) gained mixed-powder adds the distilled water immersion 1 hour of gross mass multiple 6 times, slow fire boiling 1 hour, and cross 500 order drainage screens after decocting, gained filtrate is dried in the air cool for subsequent use to room temperature;

(3) Aloe, pear, Fructus Artocarpi Heterophylli enucleation, Fructus Ananadis comosi certain kind of berries stalk, mix with Herba Portulacae, Radix Gomphostemmae, sow grass and clean, add after step (2) gained filtrate is squeezed the juice and leave standstill 2 hours, cross 1000 filter screen filtration, gained filtrate, must treat the traditional Chinese medicine liquid of asthenic fire flaring up type oral aphthae in children.