CN104826157B - A kind of multi-functional bleeding stopping and adherence preventing cotton piece containing mitomycin - Google Patents
A kind of multi-functional bleeding stopping and adherence preventing cotton piece containing mitomycin Download PDFInfo
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- CN104826157B CN104826157B CN201510251148.7A CN201510251148A CN104826157B CN 104826157 B CN104826157 B CN 104826157B CN 201510251148 A CN201510251148 A CN 201510251148A CN 104826157 B CN104826157 B CN 104826157B
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Abstract
The invention discloses for adhesion mechanism（I.e. local hematoma is formed and fibroblast proliferation）And a kind of multi-functional bleeding stopping and adherence preventing cotton piece containing mitomycin for designing, the effect of surrounding annulus hyperplasia and local precisely prevention cicatricial tissue adhesion is formed, suppressed with local accurate hemostasis, prevention hemotoncus, is unique in current anti-sticking by-product a kind of not insert internal anti-sticking by-product.Cotton piece is the most frequently used maximally effective hemostasis instrument in operation, used with disposable taking, it is convenient and swift, the advantages of haemostatic effect is notable, product of the present invention is according to the different operations requirement different to cotton piece size specification, design can reach and accurately stop blooding, avoid wasting and avoiding the purpose that hemotoncus is formed for the cotton piece of different operation demand size specifications；Certain density mitomycin C and asiaticoside are evenly distributed with cotton piece of the invention, taken into account while hemostasis with the effect for suppressing cicatricial tissue hyperplasia around fibroblast proliferation and prevention, make operative effect more significantly, operation time is saved simultaneously, make operation simple and direct rapid, reduce the risk of operation and environmental pollution.
Description
Technical field
The present invention relates to a kind of multifunctional hemostatic cotton piece, there is anti-scar, adhesion, postoperative sense the invention particularly relates to one kind
The multi-functional bleeding stopping and adherence preventing cotton piece containing mitomycin such as dye.
Background technology
Postoperative scar adhesion is the most common complication of surgery, has a strong impact on the function and outward appearance of patient, its mechanism
For operation local hematoma is formed and fibroblast proliferation, it is that cicatricial adhesion forms topmost original that wherein local hematoma is formed
Cause.Current cotton piece is best hemostasis by compression material in generally acknowledged art.Scar proliferation adhesion is past caused by operation wound and hemotoncus
Past is the reason for many surgical operation unsatisfactory curative effects even fail, and one kind well can accurately stop blooding and can accurately prevent scar to glue
Cotton piece even will bring new hope to surgical operation.Tissue cicatrization be mainly organization of hematoma and fibroblast proliferation and
Caused by the extracellular matrix biosynthesis such as collagen, and hemostasis by compression and anti-fibroblast proliferation medicine are had concurrently currently without one kind
In the anti-sticking by-product of one.Mitomycin C（Miltomycin C, MMC）With anti-fibroblast proliferation, anti-cicatrization
It is the generally acknowledged best antimetabolite that prevents adhesion etc. the effect of anti-fibroproliferation, MMC is more and more applied to ophthalmology, ear
In the various operative treatments of nose larynx Head and neck tumour, plastic surgery, gynemetrics, orthopaedics, the department of stomatology and Urology Surgery etc..One in operation
Secondary property gives mitomycin C, it will be apparent that reduce the operative failure rate caused by Post operation scar.Ophthalmology, ear nose larynx Head and neck tumour,
The correlative study of plastic surgery, gynemetrics, orthopaedics, the department of stomatology and Urology Surgery etc. also demonstrate that MMC is dense in 0.3-0.5mg/ml
Under degree, effect 5min can effectively suppress fibroblast proliferation, prevent cicatricial adhesion from being formed, and be that the mucous epithelium lid surface of a wound is carried
Advantage is supplied, the institutional framework after reparation is normal, function good, while not produced any toxic side effects to body. MMC
The treatment of the increasing anti-cicatricial adhesion that is applied to perform the operation, but the application in specific operation, mostly now match somebody with somebody in surgical procedure
Used mode：The preoperative 10mg mitomycin C pulvis for getting injection ready, is configured to the mitogen that concentration is 0.3-0.5mg/ml mould
Plain C solution, draws appropriate solution and cotton piece is soaked in kidney basin in operation with syringe, and process notes strictly observing aseptic principle,
It is applied to local operation region；It is remaining to discard often only using the mitomycin c solution of 1-5ml in operation, it is this
Mode causes the significant wastage of mitomycin C, while also increasing the risk of operation pollution, increased the time of operation.Product
Snow careless (Centella asiatica) uses existing more than 2,000 years history in China as medicinal plant, and Domestic Resources enrich, time
Cloth Yangtze river basin areas to the south.It is external to be just used as Gotu Kola P.E in 20 century 70s to promote the medicine of wound healing,
Confirmed through domestic and international long-term use, asiaticoside and its preparation, external application or for oral administration, to wound, operation wound, burn, scar
Pimple and chorionitis have determined curative effect, it is safe and reliable the features such as.
Prior art CN200510057223（Document 1）In disclose a kind of anti-scar drug film including medicine film layer, institute
It is the Silica hydrogel film layer containing medicine triamcinolone acetonide acetate and silicone oil to state medicine film layer.But the anti-scar drug film manufacture craft is answered
Miscellaneous, costly, clinical value is limited.Can cause and the drug side-effect of Triamcinolone acetonide is larger, after use pruitus,
The allergic reactions such as picotement, and easily cause patient's hormonal readiness to change, the illness such as atrophoderma and scabies secondary infection.Therefore compel
Be essential want a kind of with low cost, easy to use, manufacture craft simple and determined curative effect prevention cicatricial adhesion cotton piece.
The content of the invention
It is an object of the invention to be directed to current ophthalmology, ear nose larynx Head and neck tumour, plastic surgery, gynemetrics, orthopaedics, oral cavity
The various operation application cotton piece hemostasis of section and Urology Surgery etc. does not reach accurate hemostasis, is covered with large area more and oppressed, and easily stays
Lower space causes hemotoncus to be formed, or hemostasis region it is small need to be cut out cotton piece cause article to waste；Cotton piece only has simultaneously
Haemostatic effect, without the curative effect for suppressing surrounding annulus hyperplasia, prevention cicatricial adhesion；While original utilization mitomycin C side
Method have matching while using, complex steps, lose time, the easy deficiency such as pollution, there is provided it is a kind of easy to use while having anti-scar
Trace, adhesion, the multi-functional bleeding stopping and adherence preventing cotton piece containing mitomycin of POI.
Preparation method and application method another object of the present invention is to provide this cotton piece.
Mitomycin C and asiaticoside are preferably comprised in hemostasis cotton piece of the invention.
Cotton piece containing mitomycin C and asiaticoside of the present invention, with medical cotton piece as carrier, by medical cotton piece point
It is not vacuum dried by after mitomycin c solution and the immersion of asiaticoside solution, is uniformly attached with mitomycin C and asiaticoside
Cotton piece.The making raw material of cotton piece is identical with medical brain cotton, small to IRs such as peripheral vessels, nerves, can not only use
The hemostasis by compression in operation, it is often more important that postoperative tissue cicatricial adhesion can be prevented.The mass concentration of mitomycin c solution is excellent
Select 0.3mg/ml -0.5mg/ml；The concentration of asiaticoside solution is 0.008g/ml-0.1g/ml.
The multi-functional bleeding stopping and adherence preventing cotton piece containing mitomycin of the present invention, according to outside ophthalmology, ear nose larynx neck
The different parts such as section, plastic surgery, gynemetrics, orthopaedics, the department of stomatology and Urology Surgery operation designing four kinds of different sizes contain
The cotton piece of mitomycin C：Specification 1：0.5cm wide × 1.0cm long；Specification 2：1.0cm wide × 2.0cm long；Specification 3：2.0cm wide ×
6.0cm long；Specification 4：4.0cm wide × 10.0cm long.Small dimension cotton piece has obvious for narrow and small cavity and delicate procedure hemostasis
Advantage, the application of big specification cotton piece can make the larger surface of a wound obtain clear effective hemostasis；The cotton piece of suitable size specification should
There is the effect of prevention hemotoncus formation for region of stopping blooding；Cotton piece has the effect of prevention surrounding annulus hyperplasia.
According to the demand of different operations, there are corresponding specification and corresponding active medicine（That is MMC and asiaticoside）Mass concentration
Cotton piece adapt to therewith.Product of the present invention reduces while the caused article of cotton piece superposition is wasted and it also avoid being superimposed space hemotoncus
Formation；Other product of the present invention it also avoid preparation solution and the process of shearing cotton piece to suitable size in operation, save hand
The art operating time, make operation simple and direct rapid, reduce the risk of operation pollution.
The specific preparation method of cotton piece of the present invention, comprises the following steps：
（1）Prepare mitomycin c solution：Mitomycin C is dissolved into nutrient solution, 0.8-2mg/ml storages is configured to dense
The solution of degree, freezes in -20 degree.Suitable mass concentration is configured to when using on demand.Mass concentration using solution is preferred
0.3mg/ml, 0.4mg/ml or 0.5mg/ml.Nutrient solution can be used any conventional nutrient solution, such as serum-free medium to contain
10% serum free culture system liquid, preferably uses PBS or RPMI-1640 nutrient solutions；
（2）Prepare asiaticoside solution：In the appropriate solvent of 2.5~10g of asiaticoside, addition, stir 10-100 minutes,
It is to be dissolved after, solubilizer to 100~300ml, stirring 30 minutes it is standby.Solvent can be used the molten of any dissolvable asiaticoside
Agent, such as water, preferably purified water；Absolute ethyl alcohol, and water and ethanol arbitrary proportion mixed solvent, the concentration of asiaticoside solution
Be 0.008g/ml to 0.1g/ml, preferably 0.02,0.03,0.05g/ml；
（3）Medical cotton piece is completely immersed in 5-10 minutes in above-mentioned mitomycin c solution, bubble removing is removed；
（4）Immersion 3~8 minutes, asiaticoside solution is placed into 5-15 minutes by cotton piece, is put into smooth slipping through the net, and standing 3~
8 minutes, treat that dripless is dripped；
（5）Cotton piece is dried in ventilation；
（6）The dried cotton piece containing mitomycin C and asiaticoside is cut into dimension, is sterilized, packaging.
The application method of the multi-functional bleeding stopping and adherence preventing cotton piece containing mitomycin of the present invention, including following step
Suddenly：The cotton piece for taking appropriate specification is covered in oozing of blood region, and the liquid component that cotton piece absorbs surrounding expands and hemostasis by compression, treats clearly
Removed after haemostatic effect, then with appropriate normal saline flushing.
Cotton piece of the present invention is used for surgical operation, and single use is removed after, do not implanted.
Compared with prior art, its advantage is the present invention：
（1）The present invention designs the hemostasis cotton piece of dimension according to surgical hemostasis range size, reaches accurate compressing, accurate
The purpose of hemostasis, hemostasis is clear effectively；And the method for traditional large area compressing is difficult to observe haemostatic effect and easily causes blood
Swell and formed in superposition cotton piece periphery gap, hemostasis is fuzzy, effect on driving birds is not good.
（2）The present invention can reach accurate prevention bleeding area's fibroblast proliferation and scar is viscous while accurate hemostasis
Effect even, makes treatment more refine, and operative effect is more preferably changed；While cotton piece accurate hemostasis by compression, silk is contained in cotton piece
Rimocidin C and asiaticoside, are accurately covered in the cotton piece area of coverage, reach the accurate hyperplasia for suppressing fibroblasts from hypertrophic scars, drop
Low fibre modification, it is to avoid the action effect of unordered scar proliferation.Reach the operative effect of accurate prevention cicatricial adhesion；And pass
System application method, easily causing mitomycin c solution and sending out to normal structure influences healing.
（3）Reasonable in design, simple structure of the invention, using ophthalmology, ear nose larynx Head and neck tumour, plastic surgery, gynemetrics, bone
The different operations such as section are different to the size requirement of cotton piece, design four kinds of different sizes, the mitomycin Cs containing finite concentration scope
Cotton piece, make the still relatively open operative region of either relatively narrow and small operative region have corresponding cotton piece should
With, the therapeutic effect of operation is improved, make surgical procedure simple to operation, operating time is saved, reduce operation risk.
（4）Contain certain density mitomycin C in the multi-functional bleeding stopping and adherence preventing cotton piece containing mitomycin of the present invention,
It is not required to prepare on the spot in operation, only suitable cotton piece need to be selected to be applied to corresponding area for treatment, make to be equal to using with consumption, keeps away
Exempt from waste of traditional application method to mitomycin C, reduced medical treatment consumption, reduce the medical expense of patient；Work as with current
Prepare, cut application mode compared to clear advantage in field.
Brief description of the drawings
Fig. 1：Use hemostasis cotton piece of the invention and the cotton piece clinical comparison picture using comparative example 1.
Specific embodiment
Technical solution of the present invention is described in detail below, but protection scope of the present invention is not limited to the implementation
Example.
Embodiment 1：Prevent the mitomycin C and asiaticoside cotton piece of cicatricial adhesion, with medical cotton piece as carrier, by medical cotton
Piece by certain density mitomycin c solution and asiaticoside solution immersion after dry, be uniformly attached with mitomycin C and
The cotton piece of asiaticoside.Specifically preparation method is：
By 100cm × 100cm do not cut cotton piece as a example by：
100g mitomycin Cs are weighed, is dissolved in the 100cm × 100cm containing 100L × 20cm containers, be well mixed, matched somebody with somebody
The solution of 1mg/ml is made, is frozen in -20 degree.0.4mg/ml mitomycin c solutions are prepared, the 100cm × 100cm of 100L is poured into
In × 20cm containers, the cotton piece of 10 100cm × 100cm is completely immersed in wherein, soaks 5min, mixed, degassing weighs 3.0g
Asiaticoside is added in appropriate water, is stirred 10 minutes, it is to be dissolved after add water to 100ml, stir 30 minutes, cotton piece is put again
Enter asiaticoside solution 5-15 minutes, be respectively placed in size in the slipping through the net of 105cm × 105cm, to stand 5min, vacuum is done
It is dry, section, sterilizing, packaging.
Embodiment 2：Cotton piece is made according to the identical method of embodiment 1, difference is only molten using 0.3mg/ml mitomycin Cs
Liquid.
Embodiment 3：Cotton piece is made according to the identical method of embodiment 1, difference is only molten using 0.5mg/ml mitomycin Cs
Liquid.
Embodiment 4：Cotton piece is made according to the identical method of embodiment 1, difference only weighs the addition of 2.0g asiaticosides
In 30% appropriate ethanol water.
Embodiment 5：Cotton piece is made according to the identical method of embodiment 1, difference only weighs the addition of 5.0g asiaticosides
In appropriate water.
Embodiment 6：Cotton piece is made according to the identical method of embodiment 1, difference only weighs the addition of 8.0g asiaticosides
In appropriate water, stir 10 minutes, it is to be dissolved after add water to 300ml.
Comparative example 1：By medical cotton piece by being dried to obtain contrast cotton piece after physiological saline immersion.
100 exception section clinical operations are respectively applied to using the cotton piece made according to embodiment of the present invention 1-6 and comparative example 1
In, oozing of blood region is covered in, the liquid component that cotton piece absorbs surrounding expands and hemostasis by compression, after removal after clear and definite haemostatic effect,
Again with appropriate normal saline flushing.It is using the ratio for occurring the postoperative complications such as scar proliferation after cotton piece of the invention
3%, the ratio for the postoperative complications such as scar proliferation occur using the cotton piece of comparative example 1 is 18%.Fig. 1 is shown using of the invention
Hemostasis cotton piece and the cotton piece clinical comparison picture using comparative example 1.A：Use epidural after the cotton piece made according to embodiment
Scar is less, and surrounding tissue is loose；B：More using epidural scarring after the cotton piece made according to comparative example 1, dural sac is received
Pressure is obvious.
Can be seen that cotton piece of the invention from above-mentioned contrast effect and Fig. 1 has the hand of excellent prevention cicatricial adhesion
Art curative effect.
Claims (5)
1. a kind of preparation method of the multi-functional bleeding stopping and adherence preventing cotton piece containing mitomycin, it is characterised in that including following step
Suddenly：
（1）Prepare mitomycin c solution：Mitomycin C is dissolved into nutrient solution, 0.8-2mg/ml storage concentration is configured to
Solution, freezes in -20 degree；Suitable mass concentration is configured to when using on demand；The use of the mass concentration of solution is 0.3mg/ml,
0.4mg/ml or 0.5mg/ml；Nutrient solution uses PBS or RPMI-1640 nutrient solutions；
（2）Prepare asiaticoside solution：In the appropriate solvent of 2.5~10g of asiaticoside, addition, stir 10-100 minutes, treat molten
Xie Hou, solubilizer are to 100~300ml, and stirring 30 minutes is standby；The concentration of asiaticoside solution be 0.02g/ml, 0.03g/ml or
0.05g/ml；
（3）Medical cotton piece is completely immersed in 5-10 minutes in above-mentioned mitomycin c solution, bubble removing is removed；
（4）Cotton piece is placed into asiaticoside solution 5-15 minutes, is put into smooth slipping through the net, stand 3~8 minutes, treat that dripless is dripped
Under；
（5）Cotton piece is dried in ventilation；
（6）The dried cotton piece containing mitomycin C and asiaticoside is cut into dimension, is sterilized, packaging；
According to the size in surgical hemostasis region, using the cotton piece of different size, it can not only be pasted on bleeding area to the cotton piece
Domain has the effect of accurate hemostasis by compression, at the same can play avoid hemotoncus formed and suppress surrounding annulus hyperplasia reach it is pre-
The effect of anti-surrounding tissue scar proliferation, wherein uniformly having mitomycin C and asiaticoside.
2. the preparation method of the multi-functional bleeding stopping and adherence preventing cotton piece containing mitomycin according to claim 1, its feature
It is that described cotton piece has according to different operation demands, with four kinds of different size specifications：
Specification 1：0.5cm wide × 1.0cm long；Specification 2：1.0cm wide × 2.0cm long；Specification 3：2.0cm wide × 6.0cm long；Specification
4：4.0cm wide × 10.0cm long；Reach the effect of local accurate effectively hemostasis.
3. the preparation method of the multi-functional bleeding stopping and adherence preventing cotton piece containing mitomycin according to claim 2, its feature
It is that the cotton piece of described different size specification is applied to effect of the region with prevention hemotoncus formation of stopping blooding.
4. the preparation method of the multi-functional bleeding stopping and adherence preventing cotton piece containing mitomycin according to claim 1, its feature
It is that described cotton piece has the effect of prevention surrounding annulus hyperplasia.
5. the preparation method of the multi-functional bleeding stopping and adherence preventing cotton piece containing mitomycin according to claim 1, its feature
It is that described cotton piece has the effect of prevention local scar tissue adhesion.
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| CN201510251148.7A CN104826157B (en) | 2015-05-18 | 2015-05-18 | A kind of multi-functional bleeding stopping and adherence preventing cotton piece containing mitomycin |
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| CN104826157B true CN104826157B (en) | 2017-06-06 |
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Citations (4)
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| CN1857291A (en) * | 2006-04-04 | 2006-11-08 | 杭州茵诺邦医药科技有限公司 | Externally applied liquid asiaticoside preparation and its preparing process |
| CN101716131A (en) * | 2010-01-19 | 2010-06-02 | 武汉诺邦生物医药科技有限公司 | Medicinal cosmetic with the function of inhibiting skin fibroplasia |
| CN102451490A (en) * | 2011-12-26 | 2012-05-16 | 江苏省人民医院 | Mitomycin C cotton tablet for preventing scar adhesion and preparation method thereof |
| CN103356508A (en) * | 2012-03-27 | 2013-10-23 | 上海卫生材料厂有限公司 | Centella total glycoside cataplasm and preparation method thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101103423B1 (en) * | 2009-09-04 | 2012-01-06 | 아주대학교산학협력단 | In situ forming hydrogel for tissue adhesives and biomedical use thereof |
-
2015
- 2015-05-18 CN CN201510251148.7A patent/CN104826157B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1857291A (en) * | 2006-04-04 | 2006-11-08 | 杭州茵诺邦医药科技有限公司 | Externally applied liquid asiaticoside preparation and its preparing process |
| CN101716131A (en) * | 2010-01-19 | 2010-06-02 | 武汉诺邦生物医药科技有限公司 | Medicinal cosmetic with the function of inhibiting skin fibroplasia |
| CN102451490A (en) * | 2011-12-26 | 2012-05-16 | 江苏省人民医院 | Mitomycin C cotton tablet for preventing scar adhesion and preparation method thereof |
| CN103356508A (en) * | 2012-03-27 | 2013-10-23 | 上海卫生材料厂有限公司 | Centella total glycoside cataplasm and preparation method thereof |
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