CN104800619A - Traditional Chinese medicine for treating children nephrosis and preparation method of traditional Chinese medicine - Google Patents
Traditional Chinese medicine for treating children nephrosis and preparation method of traditional Chinese medicine Download PDFInfo
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Abstract
The invention belongs to the field of traditional Chinese medicine preparations, and particularly relates to a traditional Chinese medicine for treating children nephrosis and a preparation method of the traditional Chinese medicine. The traditional Chinese medicine for treating children nephrosis mainly comprises components in parts by weight as follows: 22-28 parts of heterophylly falsestarwort root, 22-28 parts of perilla stem , 15-21 parts of akebia stem, 6-13 parts of polyporus umbellatus, 22-28 parts of largehead atractylodes rhizome, 15-21 parts of lalang grass rhizome, 13-20 parts of common anemarrhena rhizome, 13-20 parts of sugar and 1-5 parts of dextrin. The traditional Chinese medicine has the benefits that the modern pharmacology is adopted for pharmacodynamics study of the traditional Chinese medicine, and the traditional Chinese medicine has the efficacy of immunity improvement, infection resistance, spleen and stomach regulation, spleen strengthening and dampness elimination. The costs of the raw materials are lower, so that the traditional Chinese medicine is applicable to large-scale production and easy to popularize and can be conveniently used by more patients.
Description
Technical field
The invention belongs to field of traditional Chinese, be specifically related to a kind of Chinese medicine for the treatment of children nephrosis and preparation method thereof.
Background technology
Kidney, Gu source, be the indispensable organ of health; Have the health that healthy kidney source can ensure taste, can hair strengthening spleen invigorating; Kidney is the five internal organs vitals, is the shelter of water storage, is the main force of urinary system.
Cellular immunization imbalance can cause bringing out of children nephrosis, acute renal failure, renal tubules pathological changes, infection is the cardinal symptom of children nephrosis, infection be children nephrosis must send out disease, be also murderous main cause.
In recent years, the generation of nephropathy constantly increased, and caused a series of pathological changes; Usually allow people feel simply helpless, such as uremia, impaired renal function, renal tubules filtration, glomerule Reabsorption, no longer can perform the function of each several part.
Children nephrosis, as the commonly encountered diseases in Chinese children nephropathy, has annoying many patient home.Upper respiratory tract infection history is often had before nephrotic syndrome of children infant onset, Mild edema only shows that get up in the morning, blepharoedema, the nephrotic syndrome of children infant of severe edema can have hydrosarca, pitting edema, the edema of scrotum performance light of nephrotic syndrome of children infant, Severe edema has ascites and hydrothorax.Nephrotic syndrome of children infant often has the symptoms such as tired, anorexia, listless, pale complexion, nephrotic syndrome of children infant immunologic hypofunction, thus often has infection, if treatment can be associated with hypovolemic shock not in time, electrolyte disturbance blood vessel embolism, acute renal failure etc.
Summary of the invention
For the shortcoming of the method about treatment children nephrosis existed now, the invention discloses a kind of Chinese medicine for the treatment of children nephrosis and preparation method thereof, the present invention with Radix Pseudostellariae, Caulis Perillae, the Rhizoma Atractylodis Macrocephalae etc. for principal agent, have insufficiency of the spleen foster kidney, etc. effect, there is significant curative effect to children nephrosis, be applicable to extensively promoting the use of.
Particular content of the present invention is: a kind of Chinese medicine for the treatment of children nephrosis, main components in percentage by weight by weight: Radix Pseudostellariae 22-28 part, Caulis Perillae 22-28 part, Caulis Akebiae 15-21 part, Polyporus 6-13 part, Rhizoma Atractylodis Macrocephalae 22-28 part, Rhizoma Imperatae 15-21 part, Rhizoma Anemarrhenae 13-20 part, cane sugar powder 13-20 part, dextrin 1-5 part.
Through the further research of inventor, prescription proportioning is optimized:
Radix Pseudostellariae 23-27 part, Caulis Perillae 23-27 part, Caulis Akebiae 16-20 part, Polyporus 8-12 part, Rhizoma Atractylodis Macrocephalae 23-27 part, Rhizoma Imperatae 16-20 part, Rhizoma Anemarrhenae 14-16 part, cane sugar powder 15-20 part, dextrin 1-3 part.
Prescription proportioning, through studying for a long period of time, is optimized by inventor further:
Radix Pseudostellariae 25 parts, Caulis Perillae 25 parts, Caulis Akebiae 18 parts, Polyporus 10 parts, the Rhizoma Atractylodis Macrocephalae 25 parts, Rhizoma Imperatae 18 parts, the Rhizoma Anemarrhenae 15 parts, cane sugar powder 18 parts, 2 parts, dextrin.
In above-mentioned formula: Radix Pseudostellariae baidu powder is anticipated, and with strengthening vital QI to eliminate pathogenic factors, plays the effect of sweet light dampness removing with Caulis Akebiae compatibility; Caulis Perillae sweet cold fragrance, clearing away heat with drugs sweet in flavor and cold in nature and not injuring one's stomach, fragrance thoroughly reaches and can be eliminating evil, is equipped with Polyporus and protects kidney and support spleen; The Rhizoma Atractylodis Macrocephalae is equipped with the Rhizoma Anemarrhenae, turns round and look at the moon of stomach; Rhizoma Imperatae is filled up deficit and empty is nourished taste.Adopt the various raw materials of said ratio, that reasonably arranges in pairs or groups and drug effect is played in mixing is more thorough, prevents the counteracting of drug effect between each taste Chinese medicine simultaneously.
The invention has the beneficial effects as follows: use modern pharmacology, pharmacodynamic study is carried out to the present invention, have and strengthen immunity, infection, adjustment taste, effect of invigorating the spleen for eliminating dampness.Because the cost of various raw material is lower, be applicable to large-scale production, be easy to promote, convenient more patients use.
The preparation technology of this Chinese medicine is:
(1) by the Radix Pseudostellariae warm macerating of said ratio, the temperature of immersion is 65-75 DEG C, and soak time is 1-1.5h, and water consumption is 10-15 times of Radix Pseudostellariae quality, and soak and terminate rear filtration, filtrate is for subsequent use;
(2), after Caulis Perillae, Caulis Akebiae, Polyporus, the Rhizoma Atractylodis Macrocephalae, Rhizoma Imperatae, the Rhizoma Anemarrhenae being mixed according to proportioning, add the water of above-mentioned medical material gross weight 10 times amount, start after soaking 0.5h to decoct, decocting time 1.3-2.3h; Filter, obtain filtrate; Add above-mentioned medical material gross weight 3-5 amount doubly in medicinal residues, carry out second time and decoct, decocting time is 1-1.5h, filters, obtains filtrate, and twice filtrate merges;
(3) the Radix Pseudostellariae filtrate in step 1 mixed homogeneously with the filtrate in step 2, gained filtrate is condensed into thick paste, the relative density 1.35-1.39 of gained thick paste, cane sugar powder, dextrin is added according to proportioning in thick paste, granule is become with No. 2 sieve series after mixing, dry, granulate.
Adopt above preparation technology mainly according to following reason:
(1) Radix Pseudostellariae belongs to rare medicinal herbs, and applicable temperature and time at utmost can play the property of medicine of Radix Pseudostellariae, and the long meeting of decocting time is polypeptide breakdown in Radix Pseudostellariae, therefore adopts the method for the independent warm macerating of Radix Pseudostellariae;
(2) all medicines of prescription are mainly containing effective ingredient such as sterols, organic acid, alkaloid, saccharide, aminoacid, according to the character of mentioned component, take water boiling and extraction method, in order to make the main component of ingredients fully be extracted by water boiling and extraction method, soak time, the parameters decocted in the preparation technologies such as number of times, decocting time and amount of water are set as above-mentioned each value, make each the effective elements of the medicine obtain extracting the most fully like this, play the maximum effect of drug effect;
(3) sucrose is adjuvant, plays the effect of taste masking.Add a small amount of high aqueous dextrin, not only play adhesive effect but also granule can be made to be dissolved in water rapidly when granule processed.
Pelletize described in the present invention and drying all adopt prior art, the equipment of the equipment adopted also for market can be buied.
Detailed description of the invention
Embodiment 1
Treat a Chinese medicine for children nephrosis, main components in percentage by weight by weight:
Radix Pseudostellariae 25 parts, Caulis Perillae 25 parts, Caulis Akebiae 18 parts, Polyporus 10 parts, the Rhizoma Atractylodis Macrocephalae 25 parts, Rhizoma Imperatae 18 parts, the Rhizoma Anemarrhenae 15 parts, cane sugar powder 18 parts, 2 parts, dextrin.
The preparation method of the Chinese medicine of above-mentioned treatment children nephrosis:
(1) by the Radix Pseudostellariae warm macerating of said ratio, the temperature of immersion is 80 DEG C, and soak time is 1.5h, and water consumption is 23 times of Radix Pseudostellariae quality, and soak and terminate rear filtration, filtrate is for subsequent use;
(2), after Caulis Perillae, Caulis Akebiae, Polyporus, the Rhizoma Atractylodis Macrocephalae, Rhizoma Imperatae, the Rhizoma Anemarrhenae being mixed according to proportioning, add the water of above-mentioned medical material gross weight 10 times amount, start after soaking 0.5h to decoct, decocting time 1.8h; Filter, obtain filtrate; Add the amount of above-mentioned medical material gross weight 5 times in medicinal residues, carry out second time and decoct, decocting time is 1h, filters, filtrate, twice filtrate merges;
(3) the Radix Pseudostellariae filtrate in step 1 mixed homogeneously with the filtrate in step 2, gained filtrate is condensed into thick paste, the relative density 1.37 of gained thick paste, cane sugar powder, dextrin is added according to proportioning in thick paste, granule is become with No. 2 sieve series after mixing, dry, granulate.
Using method: every day 3 times, be grown up a 6-10 gram, and child reduces by half and takes, and within 7 days, is a course for the treatment of, takes three courses for the treatment of continuously.
Embodiment 2
The present embodiment is a kind of feasible program of embodiment 1, main components in percentage by weight by weight:
Radix Pseudostellariae 22 parts, Caulis Perillae 22 parts, Caulis Akebiae 15 parts, Polyporus 6 parts, the Rhizoma Atractylodis Macrocephalae 22 parts, Rhizoma Imperatae 15 parts, the Rhizoma Anemarrhenae 13 parts, cane sugar powder 13 parts, 1 part, dextrin.
The preparation method of the Chinese medicine of above-mentioned treatment children nephrosis:
(1) by the Radix Pseudostellariae warm macerating of said ratio, the temperature of immersion is 85 DEG C, and soak time is 1h, and water consumption is 25 times of Radix Pseudostellariae quality, and soak and terminate rear filtration, filtrate is for subsequent use;
(2), after Caulis Perillae, Caulis Akebiae, Polyporus, the Rhizoma Atractylodis Macrocephalae, Rhizoma Imperatae, the Rhizoma Anemarrhenae being mixed according to proportioning, add the water of above-mentioned medical material gross weight 10 times amount, start after soaking 0.5h to decoct, decocting time 1.3h; Filter, obtain filtrate; Add the amount of above-mentioned medical material gross weight 4 times in medicinal residues, carry out second time and decoct, decocting time is 1.5h, filters, obtains filtrate, and twice filtrate merges;
(3) the Radix Pseudostellariae filtrate in step 1 mixed homogeneously with the filtrate in step 2, gained filtrate is condensed into thick paste, the relative density 1.39 of gained thick paste, cane sugar powder, dextrin is added according to proportioning in thick paste, granule is become with No. 2 sieve series after mixing, dry, granulate.
Using method: every day 3 times, be grown up a 6-10 gram, and child reduces by half and takes, and within 7 days, is a course for the treatment of, takes three courses for the treatment of continuously.
Embodiment 3
The main components in percentage by weight of the present embodiment is by weight:
Radix Pseudostellariae 28 parts, Caulis Perillae 28 parts, Caulis Akebiae 21 parts, Polyporus 13 parts, the Rhizoma Atractylodis Macrocephalae 28 parts, Rhizoma Imperatae 21 parts, the Rhizoma Anemarrhenae 20 parts, cane sugar powder 20 parts, 5 parts, dextrin.
The preparation method of the Chinese medicine of above-mentioned treatment children nephrosis:
(1) by the Radix Pseudostellariae warm macerating of said ratio, the temperature of immersion is 75 DEG C, and soak time is 1.5h, and water consumption is 23 times of Radix Pseudostellariae quality, and soak and terminate rear filtration, filtrate is for subsequent use;
(2), after Caulis Perillae, Caulis Akebiae, Polyporus, the Rhizoma Atractylodis Macrocephalae, Rhizoma Imperatae, core Adiantum monochlamys Eaton., the Rhizoma Anemarrhenae being mixed according to proportioning, add the water of above-mentioned medical material gross weight 10 times amount, start after soaking 0.5h to decoct, decocting time 2h; Filter, obtain filtrate; Add the amount of above-mentioned medical material gross weight 6 times in medicinal residues, carry out second time and decoct, decocting time is 1h, filters, obtains filtrate, and twice filtrate merges;
(3) the Radix Pseudostellariae filtrate in step 1 mixed homogeneously with the filtrate in step 2, gained filtrate is condensed into thick paste, the relative density 1.35 of gained thick paste, cane sugar powder, dextrin is added according to proportioning in thick paste, granule is become with No. 2 sieve series after mixing, dry, granulate.
Using method: every day 3 times, be grown up a 6-10 gram, and child reduces by half and takes, and within 7 days, is a course for the treatment of, takes three courses for the treatment of continuously.
Embodiment 4
The main components in percentage by weight of the present embodiment is by weight:
Radix Pseudostellariae 27 parts, Caulis Perillae 27 parts, Caulis Akebiae 20 parts, Polyporus 12 parts, the Rhizoma Atractylodis Macrocephalae 27 parts, Rhizoma Imperatae 12 parts, the Rhizoma Anemarrhenae 16 parts, cane sugar powder 15 parts, 3 parts, dextrin.
The preparation method of the Chinese medicine of above-mentioned treatment children nephrosis:
(1) by the Radix Pseudostellariae warm macerating of said ratio, the temperature of immersion is 80 DEG C, and soak time is 1.5h, and water consumption is 23 times of Radix Pseudostellariae quality, and soak and terminate rear filtration, filtrate is for subsequent use;
(2), after Caulis Perillae, Caulis Akebiae, Polyporus, the Rhizoma Atractylodis Macrocephalae, Rhizoma Imperatae, core Adiantum monochlamys Eaton., the Rhizoma Anemarrhenae being mixed according to proportioning, add the water of above-mentioned medical material gross weight 10 times amount, start after soaking 0.5h to decoct, decocting time 2.3h; Filter, obtain filtrate; Add the amount of above-mentioned medical material gross weight 5 times in medicinal residues, carry out second time and decoct, decocting time is 1h, filters, obtains filtrate, and twice filtrate merges;
(3) the Radix Pseudostellariae filtrate in step 1 mixed homogeneously with the filtrate in step 2, gained filtrate is condensed into thick paste, the relative density 1.38 of gained thick paste, cane sugar powder, dextrin is added according to proportioning in thick paste, granule is become with No. 2 sieve series after mixing, dry, granulate.
Using method: every day 3 times, be grown up a 6-10 gram, and child reduces by half and takes, and within 7 days, is a course for the treatment of, takes three courses for the treatment of continuously.
Embodiment 5
The main components in percentage by weight of the present embodiment is by weight:
Radix Pseudostellariae 23 parts, Caulis Perillae 23 parts, Caulis Akebiae 16 parts, Polyporus 8 parts, the Rhizoma Atractylodis Macrocephalae 23 parts, Rhizoma Imperatae 16 parts, the Rhizoma Anemarrhenae 14 parts, cane sugar powder 15 parts, 1 part, dextrin.
The preparation method of the Chinese medicine of above-mentioned treatment children nephrosis:
(1) by the Radix Pseudostellariae warm macerating of said ratio, the temperature of immersion is 80 DEG C, and soak time is 1.5h, and water consumption is 23 times of Radix Pseudostellariae quality, and soak and terminate rear filtration, filtrate is for subsequent use;
(2), after Caulis Perillae, Caulis Akebiae, Polyporus, the Rhizoma Atractylodis Macrocephalae, Rhizoma Imperatae, core Adiantum monochlamys Eaton., the Rhizoma Anemarrhenae being mixed according to proportioning, add the water of above-mentioned medical material gross weight 10 times amount, start after soaking 0.5h to decoct, decocting time 2.3h; Filter, obtain filtrate; Add the amount of above-mentioned medical material gross weight 5 times in medicinal residues, carry out second time and decoct, decocting time is 1h, filters, obtains filtrate, and twice filtrate merges;
(3) the Radix Pseudostellariae filtrate in step 1 mixed homogeneously with the filtrate in step 2, gained filtrate is condensed into thick paste, the relative density 1.38 of gained thick paste, cane sugar powder, dextrin is added according to proportioning in thick paste, granule is become with No. 2 sieve series after mixing, dry, granulate.
Using method: every day 3 times, be grown up a 6-10 gram, and child reduces by half and takes, and within 7 days, is a course for the treatment of, takes three courses for the treatment of continuously.
Comparative example:
Outpatient service be diagnosed as children nephrosis patient 186 example, male 77 example, women 109 example, age characteristics 17-65 year.Random point two groups, wherein treatment group 102 example, matched group 84 example.
Treatment group in conjunction with the goods obtained by the oral embodiment 1 of clinical symptoms, each 10g, every day 3 times; The pure western medicine of matched group, a 6g, every day 2 times, often organizing equal seven days is a course for the treatment of.
Contrast standard: medication is after 3 days, and renal function recovers to some extent, sb.'s illness took a favorable turn is effective.More than 5 days symptoms without alleviation be improved as invalid.
Comparative test result sees the following form:
Clinical observation on the therapeutic effect table
| Effectively | Invalid | Cure rate | |
| Treatment group 1 | 99 examples | 3 examples | 97％ |
| Treatment group 2 | 92 examples | 10 examples | 90％ |
| Treatment group 3 | 95 examples | 7 examples | 93％ |
| Treatment group 4 | 90 examples | 12 examples | 88％ |
| Treatment group 5 | 97 examples | 5 examples | 95％ |
| Matched group | 72 examples | 12 examples | 86％ |
From upper result, treat the Western medicine that five groups of goods taken take than matched group and more effectively can cure children nephrosis, wherein treatment group 1 best results.
Claims (4)
1. treat a Chinese medicine for children nephrosis, main components in percentage by weight by weight: Radix Pseudostellariae 22-28 part, Caulis Perillae 22-28 part, Caulis Akebiae 15-21 part, Polyporus 6-13 part, Rhizoma Atractylodis Macrocephalae 22-28 part, Rhizoma Imperatae 15-21 part, Rhizoma Anemarrhenae 13-20 part, cane sugar powder 13-20 part, dextrin 1-5 part.
2. a kind of Chinese medicine for the treatment of children nephrosis according to claim 1, main components in percentage by weight by weight: Radix Pseudostellariae 23-27 part, Caulis Perillae 23-27 part, Caulis Akebiae 16-20 part, Polyporus 8-12 part, Rhizoma Atractylodis Macrocephalae 23-27 part, Rhizoma Imperatae 16-20 part, Rhizoma Anemarrhenae 14-16 part, cane sugar powder 15-20 part, dextrin 1-3 part.
3. a kind of Chinese medicine for the treatment of children nephrosis according to claim 1, main components in percentage by weight by weight: Radix Pseudostellariae 25 parts, Caulis Perillae 25 parts, Caulis Akebiae 18 parts, Polyporus 10 parts, the Rhizoma Atractylodis Macrocephalae 25 parts, Rhizoma Imperatae 18 parts, the Rhizoma Anemarrhenae 15 parts, cane sugar powder 18 parts, 2 parts, dextrin.
4. a kind of preparation method for the treatment of the Chinese medicine of children nephrosis described in claim 1:
(1) by the Radix Pseudostellariae warm macerating of said ratio, the temperature of immersion is 65-75 DEG C, and soak time is 1-1.5h, and water consumption is 10-15 times of Radix Pseudostellariae quality, and soak and terminate rear filtration, filtrate is for subsequent use;
(2), after Caulis Perillae, Caulis Akebiae, Polyporus, the Rhizoma Atractylodis Macrocephalae, Rhizoma Imperatae, the Rhizoma Anemarrhenae being mixed according to proportioning, add the water of above-mentioned medical material gross weight 10 times amount, start after soaking 0.5h to decoct, decocting time 1.3-2.3h; Filter, obtain filtrate; Add above-mentioned medical material gross weight 3-5 amount doubly in medicinal residues, carry out second time and decoct, decocting time is 1-1.5h, filters, obtains filtrate, and twice filtrate merges;
(3) the Radix Pseudostellariae filtrate in step 1 mixed homogeneously with the filtrate in step 2, gained filtrate is condensed into thick paste, the relative density 1.35-1.39 of gained thick paste, cane sugar powder, dextrin is added according to proportioning in thick paste, granule is become with No. 2 sieve series after mixing, dry, granulate.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107582983A (en) * | 2017-10-01 | 2018-01-16 | 河南科技大学第附属医院 | A kind of Chinese medicine for treating Childhood Nephrotic Syndrome and preparation method thereof |
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| CN101983699A (en) * | 2010-11-16 | 2011-03-09 | 西安融慧专利产品开发咨询有限责任公司 | Traditional Chinese medicine composition for treating kidney disease and preparation method thereof |
| CN103007228A (en) * | 2012-12-27 | 2013-04-03 | 李莉 | Medicine for treating infantile nephrotic syndrome |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101983699A (en) * | 2010-11-16 | 2011-03-09 | 西安融慧专利产品开发咨询有限责任公司 | Traditional Chinese medicine composition for treating kidney disease and preparation method thereof |
| CN103007228A (en) * | 2012-12-27 | 2013-04-03 | 李莉 | Medicine for treating infantile nephrotic syndrome |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107582983A (en) * | 2017-10-01 | 2018-01-16 | 河南科技大学第附属医院 | A kind of Chinese medicine for treating Childhood Nephrotic Syndrome and preparation method thereof |
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