CN104798997A - Special dog health care daily ration for regulating blood sugar and feeding method of special dog health care daily ration - Google Patents
Special dog health care daily ration for regulating blood sugar and feeding method of special dog health care daily ration Download PDFInfo
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Abstract
The invention discloses special dog health care daily ration for regulating blood sugar and a feeding method of the special dog health care daily ration. The special dog health care daily ration comprises the following components: 15-25% of corn, 10-15% of dried amaranthus retroflexus powder, 0.1-0.2% of alligator alternanthera extract, 10-15% of konjaku flour, 40-50% of chicken, 0.1-0.2% of decavitamin, 0.1-0.2% of microelement compound, 2-4% of a phagostimulant, 1-5% of corn oil and 1-2% of monocalcium phosphate. The special dog health care daily ration has the efficacy of auxiliarly regulating the in-vivo blood sugar level, can have certain preventive effect on dogs in the prediabetic state, reduces and stabilizes blood sugar to reduce the occurrence risk of diabetes mellitus, has certain auxiliary blood sugar reduction efficacy for dogs suffering from diabetes mellitus to achieve the purpose of reducing complication and prolongs the life span of the dogs suffering from diabetes mellitus, and can reduce the health risk to the dogs caused by high blood sugar through reducing oxidative damage caused by high blood sugar and improving the immunity of the organism.
Description
Technical field
The invention belongs to animal health-care product field, be mainly specifically related to a kind of the proprietary formula daily ration and the feeding method thereof that regulate a dog blood sugar.
Background technology
Diabetes are the metabolic disorders of the complexity caused by many factors, under it is characterized in that the relative or absolute minimizing situation of insulin, or insulin is impaired, thus causes obtaining not tolerating of carbohydrate to food or from gluconeogenesis, blood sugar concentration is raised, produces hyperglycemia.Blood sugar is too high, exceed glucose kidney threshold values (dog is 9.8-12mmol) time, just produce glycosuria.Glycosuria, except causing hypertonicity diuresis and polydipsia, due to blood sugar, energetic supersession disorder, causes hunger and eats more; When insulin deficit, the synthesis of animal body internal protein and fat reduces, and decomposing reinforcement is lose weight.Diabetic animal has more than three one light clinical symptoms, namely diuresis, many drinks, eat more and lose weight.The normal fasting blood-glucose 3.9-6.1mmol/L of dog, the blood sugar 4.4-7.8mmol/L of two hours after the meal, as being empty stomach 6.1 ~ 6.9mmol/L, 7.8 ~ 11.1mmol/L is prediabetes (IFG or impaired glucose tolerance) after the meal.
The cause of disease of dog diabetes is still not clear, is the result of many factors compound action.The cause of disease causing diabetes is thought in heredity, infection, medicine, obesity, pancreatitis, immune mediating pancreatitis etc., and research finds that long-term nutrition is excessive, makes animal obesity, thus causes the minimizing of invertibity insulin secretion; Some drugs and diabetes have close contacting, as glucocorticoid and progestogens etc., application class sterol can make liver gluconeogenesis strengthen, to fly up and down insulin, reduce tissue to glucose utilization, improve blood sugar level, but in most of the cases, after discontinuing medication, namely glycosuria disease recovers normal, and application progestational hormone also can cause invertibity glycosuria disease; In addition, application corticotropin, hyperglycemic factor, estrogen, adrenaline etc., also can bring out dog glycosuria disease; Non-steroidal drug (chlorpromazine, diphenyl hydantoin dilantin etc.) also can cause hyperglycemia, and endogenous cortex hormone of aadrenaline hypersecretion and dog diabetes have comparatively Important Relations; Estrogen and the progestational hormone of release when bitch is oestrused can reduce insulin action, and therefore, glycosuria disease can appear in bitch during oestrus; Stress be the main cause that another kind causes diabetes, comprise wound, infection, gestation and various acute diseases etc.Stress make is the hormone of antagonistic action with insulin, and as cortisol, hyperglycemic factor, growth hormone and adrenaline secretion function strengthen, insulin secretion reduces, thus blood sugar raises.
The diabetes of nearly all dog are all insulin-dependent diabetes mellitus, i.e. IDDM (insulin-dependent diabetesmellitus, IDDM), and the feature of this patients with type Ⅰ DM is hypoinsulinemia.During most dog generation diabetes be 4-14 year, 7-9 year be occurred frequently, the female incidence of disease is male 2 times.Keeshond parentage analysis shows that this dog exists genetic predisposition.The epidemiology that Guptill etc. 1999 do investigation shows Australia dog, fox-terrier, Yorkshire Terrier, Xue Narui, than bear dog, Poodle Sa Moye dog and Lhasa Apso have diabetes easily to send out tendency.The common symptom of diabetes shows as many drinks, diuresis, many foods and Body weight loss.Only have hyperglycaemia to cause just to there will be during glycosuria and drink diuresis more, iatrogenic hypoglycemia, cataract, lower urinary tract bacteriological infection, pancreatitis, DKA, liver lipidosis syndrome etc. are common complication.Sometimes, animal owner can remove hospital admission because it is blind suddenly, and typical " three-many-one-little " disease is out in the cold, and now suffers from dog and may occur gradual DKA.The object for the treatment of eliminates the clinical symptoms being secondary to hyperglycaemia and glycosuria.The fluctuation of restriction blood sugar and maintain and be conducive to alleviating clinical symptoms close to normal blood sugar concentration, prevents the appearance of complication, therefore researches and develops the daily ration that is more applicable to diabetes dog and scale of feeding is even more important.
Summary of the invention
The object of this invention is to provide and a kind ofly coordinate dog health care formula daily ration and the feeding method thereof of other components and basal nutrient material with Amaranthus retroflexus and alternanthera philoxeroides extract for main composition.This dog health care formula daily ration has effect of blood sugar level in auxiliary adjustment body.For being in prediabetes dog only to play certain prevention effect, reduce and stabilizing blood sugar thus reduce the occurrence risk of diabetes; Effect of certain auxiliary hyperglycemic is only then had for suffering from diabetes dog, thus reach the object in minimizing complication prolongation trouble dog life-span, and the health risk that the oxidative damage caused by reducing hyperglycaemia only brings dog with raising immunity of organisms downward hyperglycaemia.
Object of the present invention realizes in the following manner:
A kind of dog special health daily ration regulating blood sugar, comprise following percentage by weight raw material: corn 15 ~ 25%, Amaranthus retroflexus dry powder 10 ~ 15%, alternanthera philoxeroides extract 0.1 ~ 0.2%, konjaku flour 10 ~ 15%, chicken 40 ~ 50%, B B-complex 0.1 ~ 0.2%, trace element mixture 0.1 ~ 0.2%, phagostimulant 2 ~ 4%, corn oil 1 ~ 5%, calcium dihydrogen phosphate 1 ~ 2%.
Amaranthus retroflexus dry powder gets fresh Amaranthus retroflexus complete stool to clean, and dry more than 4 hours with air flow dryer, make final water content be less than 5%, micronizer is ground into powder.
The flavones content of alternanthera philoxeroides extract is not less than 2.5%, and total saponin content is not less than 13%, and content of luteolin is not less than 0.1%, and content of oleanolic acid is not less than 0.15%.Can purchased from Xi'an Bioisystech Co., Ltd of Tianrui.
B B-complex comprises: Choline Chloride, vitamin A, vitamine D3, vitamin E, vitamin B1, calcium pantothenate, vitamin B6, riboflavin, folic acid, biotin, vitamin B12.(purchased from Jinan Jin Hui Chemical Co., Ltd.)
Trace element mixture comprises: ferrous sulfate, Copper lysinate, zinc methionine, manganese sulfate, sodium selenite, Potassiumiodate, cobalt chloride.Purchased from Beijing You Libao biotechnology Co., Ltd.
Phagostimulant is purchased from Xuzhou Pu Rui animal nutritious health Co., Ltd
The feeding method of the dog special health daily ration of described adjustment blood sugar is as follows:
Amaranthus retroflexus: Amaranthus retroflexus contains abundant iron, calcium, carrotene and vitamin C, in addition containing several amino acids, especially containing lysine, be that body is necessary, and in the cereal such as corn, wheat, rice, content is less.Medical value, cool in nature, taste is sweet, has removing heat to brighten vision, smoothening secretion, astringing to reduce edema, removing toxic substances control the effect such as dysentery, anti-inflammatory hemostasis.
Alternanthera philoxeroides: nature and flavor, sweet, cold in nature, bitter.There is reducing fever and causing diuresis, cool blood, effect of removing toxic substances.
Corn: dog basal energy is provided;
Konjaku flour: its feature is exactly low calorie, low-protein, low vitamin, high dietary-fiber.The viscosity of its konjaku glucomannan be rich in is very large, enhances the viscosity of chyme in alimentary canal, has delayed the holdup time that in gastral cavity, chyme is stuck with paste, and form diaphragm at intestines wall, effectively suppress the rising of blood glucose value and urine sugar value.In addition, because the bonding pattern of Glucomannan monose is similar with cellulose, monose can not be degraded to absorb, so be applicable to the situation that diabetes patient etc. can not take in polysaccharide in small intestine.
Chicken: containing the nutriment such as rich in protein, minerals and vitamins, for dog provides basal energy;
B B-complex: provide daily necessary vitamin, maintains body health, the necessary class organic compound of regulation of physiological functions.
Trace element mixture: provide body daily necessary trace element.
Phagostimulant: the palatability improving dog grain, promotes letting animals feed appetite.
Corn oil: can provide the basal energy needed for body, simultaneously because the ratio row of unrighted acid connect higher, significantly can reduce the cholesterol level in blood, have positive preventive and therapeutic effect to diabetes etc.
Advantage of the present invention:
1, the present invention adopts compound Amaranthus retroflexus and alternanthera philoxeroides extract to be that the health care Diet Formula of main composition significantly can reduce diabetes dog blood-sugar content only, make dog glucose in urine only and ketoboidies detect positive rate also significantly to reduce, and by reducing the initiated oxidation damage of hyperglycaemia institute and improving the adjuvant treatment effect that immunity of organisms reaches reduction diabetic complication.
2, the present invention that the feeds daily ration that keeps healthy significantly can reduce dog blood sugar concentration only, and stabilizing blood sugar concentration in use for some time, the pathogenetic effect of prevention glycosuria can be played to a certain extent.
3, Amaranthus retroflexus and alternanthera philoxeroides extract are used alone more remarkable with the use of regulating the effect of blood sugar ratio by daily ration of the present invention.
Detailed description of the invention
Be intended to further illustrate the present invention below in conjunction with embodiment, and unrestricted the present invention.
Embodiment 1
Choose 40 diabetes dogs, be divided into 4 groups, often organize 10, to feed following component daily ration 30 days: A group according to recommendation normative reference: normal Diet group; B group: corn 23.6%, Amaranthus retroflexus dry powder 15%, alternanthera philoxeroides extract 0.1%, konjaku flour 15%, chicken 40%, B B-complex 0.2%, trace element mixture 0.1%, phagostimulant 2%, corn oil 3%, calcium dihydrogen phosphate 1%; C group: corn 21.5%, Amaranthus retroflexus dry powder 15%, alternanthera philoxeroides extract 0.2%, konjaku flour 12%, chicken 45%, B B-complex 0.2%, trace element mixture 0.1%, phagostimulant 2%, corn oil 3%, calcium dihydrogen phosphate 1%; D group: corn 25%, Amaranthus retroflexus dry powder 15%, alternanthera philoxeroides extract 0.2%, konjaku flour 13.5%, chicken 40%, B B-complex 0.2%, trace element mixture 0.1%, phagostimulant 2%, corn oil 3%, calcium dihydrogen phosphate 1%.Above-mentioned material is weighed on request, is placed in mixer, mixes, the health care daily ration mixed is granulated, packs, sealed.To feed 30 days on an empty stomach venous blood collections afterwards, analyze blood-sugar content, serum oxidative damage criterion and immune indexes, find to get through feeding experiment, adopt formula of the present invention significantly can reduce the content of MDA in the blood sugar of diabetes dog and blood, and significantly improve the activity of SOD in blood, and immunoglobulin (Ig) (IgG, IgM, IgA) and complement (C3, C4) content.Present invention achieves described effect as seen, compound Amaranthus retroflexus of the present invention and alternanthera philoxeroides extract is adopted to be that the health care Diet Formula of main composition significantly can reduce diabetes dog blood-sugar content only, and reach by reducing the initiated oxidation damage of hyperglycaemia institute and improving immunity of organisms the adjuvant treatment effect reducing diabetic complication, concrete outcome is as follows:
On the impact of blood sugar in table 1, on the impact of immune indexes in table 2.
Table 1 is on the impact of blood sugar and serum oxidative damage criterion
| Grouping | Blood glucose value (mmol/L) | MDA content (nmol/ml) | SOD activity (U/ml) |
| A group | 9.13±2.24 | 9.67±0.49 | 4.27±0.57 |
| B group | 4.63±2.37** | 5.24±0.35** | 8.67±0.72** |
| C group | 4.26±1.68** | 4.87±0.38** | 9.51±0.63** |
| D group | 4.08±2.16** | 5.03±0.49** | 9.26±0.58** |
Note: compare with A group, * represents P<0.05, significant difference; * represents P<0.01, and difference is extremely remarkable, lower same.
Table 2 is on the impact of immune indexes
| Grouping | IgG(mg/L) | IgM(mg/L) | IgA(mg/L) | C3(mg/L) | C4(mg/L) |
| A group | 42.34±4.67 | 39.57±3.46 | 25.14±3.52 | 26.11±3.68 | 23.41±2.97 |
| B group | 53.57±5.81** | 48.48±5.04** | 33.35±4.54** | 30.14±5.24** | 31.64±4.65** |
| C group | 50.16±3.73** | 51.63±3.95** | 31.71±4.25** | 32.25±3.47** | 29.86±3.86** |
| D group | 56.35±6.27** | 47.26±4.65** | 29.62±3.32** | 31.48±3.22** | 31.21±4.91** |
Embodiment 2
Choose 20 diabetes dogs, be divided into A, B two groups, to feed continuously following daily ration 60 days: A group according to recommendation normative reference: normal Diet group; B group: corn 23.5%, Amaranthus retroflexus dry powder 13%, alternanthera philoxeroides extract 0.2%, konjaku flour 15%, chicken 42%, B B-complex 0.2%, trace element mixture 0.1%, phagostimulant 2%, corn oil 3%, calcium dihydrogen phosphate 1%.Above-mentioned material is weighed on request, is placed in mixer, mixes, the health care daily ration mixed is granulated, packs, sealed.1st, 7,14, the 30 and 60 day empty stomach venous blood collection of feeding, its change of blood sugar of continuous monitoring, result achieves effect of the present invention through feeding experiment, compound Amaranthus retroflexus of the present invention of feeding health care Diet Formula significantly can reduce diabetes dog blood sugar concentration only, and phase Absorbable organic halogens maintains blood sugar concentration after the test.Related experiment result is as follows:
On the impact of blood sugar in table 3.
Table 3 is on the impact of blood sugar
Note: compare with 1d, * represents P<0.05, significant difference; * represents P<0.01, and difference is extremely remarkable.A group compares # with B group and represents P<0.05, significant difference; ## represents P<0.01, and difference is extremely remarkable.
Embodiment 3
Choose 40 diabetes dogs, be divided into A, B two groups, to feed continuously following daily ration 30 days: A group according to recommendation normative reference: normal Diet group; B group: corn 23.5%, Amaranthus retroflexus dry powder 13%, alternanthera philoxeroides extract 0.2%, konjaku flour 15%, chicken 42%, B B-complex 0.2%, trace element mixture 0.1%, phagostimulant 2%, corn oil 3%, calcium dihydrogen phosphate 1%.Above-mentioned material is weighed on request, is placed in mixer, mixes, the health care daily ration mixed is granulated, packs, sealed.And the change of monitoring the positive rate of glucose in urine and ketoboidies in urine on the the 1st, 7,14 and 30 day with test paper continuously of feeding, also show feed compound Amaranthus retroflexus of the present invention health care Diet Formula dog glucose in urine only and ketoboidies and detect positive rate and also significantly reduce.
On the impact of glucose in urine, ketoboidies in table 4.
Table 4 is on the impact of glucose in urine, ketoboidies
A group is the common daily ration group of dog; B group is instant component interpolation group;
Embodiment 4
Choose 20 and be in prediabetes but the dog also do not fallen ill, be divided into A, B two groups, to feed continuously following daily ration 60 days: A group according to recommendation normative reference: normal Diet group; B group: corn 22.5%, Amaranthus retroflexus dry powder 14%, alternanthera philoxeroides extract 0.2%, konjaku flour 15%, chicken 42%, B B-complex 0.2%, trace element mixture 0.1%, phagostimulant 2%, corn oil 3%, calcium dihydrogen phosphate 1%.Above-mentioned material is weighed on request, is placed in mixer, mixes, the health care daily ration mixed is granulated, packs, sealed.The venous blood collection after the meal at the 1st, 7,14,30 and 60 day that feeds, its change of blood sugar of continuous monitoring, result achieves effect of the present invention through feeding experiment, compound Amaranthus retroflexus of the present invention of feeding health care Diet Formula significantly can reduce dog blood sugar concentration only, and stabilizing blood sugar concentration in use for some time, the pathogenetic effect of prevention glycosuria can be played to a certain extent.Related experiment result is as following table 5.
Table 5 is on the impact of postprandial blood sugar
Note: compare with 1d, * represents P<0.05, significant difference; * represents P<0.01, and difference is extremely remarkable.A group compares # with B group and represents P<0.05, significant difference; ## represents P<0.01, and difference is extremely remarkable.
Embodiment 5
Application Streptozotocin (streptozotocin, STZ) lumbar injection SD rat sets up IDDM model, 40 are chosen from the diabetes model SD rat that success is set up, Four composition is divided into not feed containing the daily ration of following composition: A group: normal Diet group, B group: add the Amaranthus retroflexus dry powder of 15% in daily ration, C group: add the alternanthera philoxeroides extract of 0.2% in daily ration, D group: the alternanthera philoxeroides extract adding the Amaranthus retroflexus dry powder+0.2% of 15% in daily ration, feed continuously 30 days, tail vein blood on an empty stomach, analyzes blood sugar concentration.By the blood sugar level that with the addition of 15% Amaranthus retroflexus and 0.2% alternanthera philoxeroides extract in the visible daily ration of result respectively and all can significantly reduce IDDM rat, 15% Amaranthus retroflexus and 0.2% alternanthera philoxeroides extract are with the use of then regulating the effect of blood sugar more remarkable.
Table 6 heterogeneity is on the impact of blood sugar
| Grouping | Blood sugar (mmol/L) |
| Normal daily ration group | 10.52±3.26 |
| 15% Amaranthus retroflexus group | 6.13±2.41** |
| 0.2% alternanthera philoxeroides extract group | 7.65±3.07** # |
| 15% Amaranthus retroflexus group+0.2% alternanthera philoxeroides extract group | 5.37±1.86** #△△ |
Note: compare with normal daily ration group, * represents P<0.05, significant difference; * represents P<0.01, and difference is extremely remarkable.Compare # with 15% Amaranthus retroflexus group and represent P<0.05, significant difference; ## represents P<0.01, and difference is extremely remarkable.With 0.2% alternanthera philoxeroides extract group comparatively
△represent P<0.05, significant difference;
△ △represent P<0.01, difference is extremely remarkable.
The reference feeding standard of the various embodiments described above is as follows:
| the weight range of dog | every natural gift are fed for 2-3 time, and total amount of feeding every day is as follows: |
| 1-4.5kg | 40-50g |
| 4.5-11.5kg | 55-100g |
| 11.5-25kg | 70-120g |
| 25-35kg | 120-180g |
| >35kg | 180-350g. |
Claims (6)
1. one kind regulates the dog special health daily ration of blood sugar, it is characterized in that, comprise following percentage by weight raw material: corn 15 ~ 25%, Amaranthus retroflexus dry powder 10 ~ 15%, alternanthera philoxeroides extract 0.1 ~ 0.2%, konjaku flour 10 ~ 15%, chicken 40 ~ 50%, B B-complex 0.1 ~ 0.2%, trace element mixture 0.1 ~ 0.2%, phagostimulant 2 ~ 4%, corn oil 1 ~ 5%, calcium dihydrogen phosphate 1 ~ 2%.
2. the dog special health daily ration of adjustment blood sugar according to claim 1, is characterized in that, Amaranthus retroflexus dry powder gets fresh Amaranthus retroflexus complete stool to clean, and dry more than 4 hours with air flow dryer, make final water content be less than 5%, micronizer is ground into powder.
3. the dog special health daily ration of adjustment blood sugar according to claim 1, it is characterized in that, the flavones content of alternanthera philoxeroides extract is not less than 2.5%, and total saponin content is not less than 13%, content of luteolin is not less than 0.1%, and content of oleanolic acid is not less than 0.15%.
4. the dog special health daily ration of adjustment blood sugar according to claim 1, it is characterized in that, B B-complex comprises: Choline Chloride, vitamin A, vitamine D3, vitamin E, vitamin B1, calcium pantothenate, vitamin B6, riboflavin, folic acid, biotin, vitamin B12.
5. the dog special health daily ration of adjustment blood sugar according to claim 1, it is characterized in that, trace element mixture comprises: ferrous sulfate, Copper lysinate, zinc methionine, manganese sulfate, sodium selenite, Potassiumiodate, cobalt chloride.
6. claim 1 ?the feeding method of dog special health daily ration of adjustment blood sugar described in 5 any one, it is characterized in that,
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| WO2024038251A1 (en) * | 2022-08-16 | 2024-02-22 | The Royal Veterinary College | Method and treatment for diabetes in dogs |
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| WO2024038251A1 (en) * | 2022-08-16 | 2024-02-22 | The Royal Veterinary College | Method and treatment for diabetes in dogs |
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