CN104667897A - Styrene-series resin adsorbent new structural product for removing high endotoxin from blood - Google Patents
Styrene-series resin adsorbent new structural product for removing high endotoxin from blood Download PDFInfo
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- CN104667897A CN104667897A CN201510120761.5A CN201510120761A CN104667897A CN 104667897 A CN104667897 A CN 104667897A CN 201510120761 A CN201510120761 A CN 201510120761A CN 104667897 A CN104667897 A CN 104667897A
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
- B01J20/26—Synthetic macromolecular compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3627—Degassing devices; Buffer reservoirs; Drip chambers; Blood filters
- A61M1/3633—Blood component filters, e.g. leukocyte filters
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2220/00—Aspects relating to sorbent materials
- B01J2220/40—Aspects relating to the composition of sorbent or filter aid materials
- B01J2220/48—Sorbents characterised by the starting material used for their preparation
- B01J2220/4812—Sorbents characterised by the starting material used for their preparation the starting material being of organic character
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- General Health & Medical Sciences (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- External Artificial Organs (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
The invention discloses a styrene-series resin adsorbent new structural product for removing high endotoxin from blood. The aperture of the adopted styrene-series new structural resin is 0 to 40 nm, wherein the content of the resin with the aperture of 20 to 40 nm is not lower than 60 percent, and/or the aperture of the resin is 0 to 60 nm, wherein the content of the resin with the aperture of 40 to 60 nm is not lower than 60 percent. When the product is used as an adsorbent in a hemoperfusion device, the resin with para-position valence functional groups and suitable aperture is selected to fill the hemoperfusion device according to the valence properties and the particle sizes of the adsorbed high endotoxin substances.
Description
Technical field
The present invention relates to the phenylethylene resin series adsorbent for removing high endotoxin material in blood.
Background technology
Phenylethylene resin series in prior art, comprises styrene-divinylbenzene macroreticular resin etc. as adsorbent, is widely used.
In medical resin adsorbent application, modern medicine is to " virulence factor " systematic achievement in research.And to adopt blood purification therapy to remove " virulence factor " from human peripheral blood be a kind of simple and effective approach.To remove for the purpose of " virulence factor ", development new construction adsorbent material is put on the agenda.
Summary of the invention
The present invention is an embodiment of earlier application patent of invention, and earlier application patent name is " the new construction product of phenylethylene resin series, preparation method and its usage ", application number: 201310347458.X.
The object of the invention is to propose the technical scheme for removing high endotoxic phenylethylene resin series adsorbent new construction product in blood.By changing the structure of matter of phenylethylene resin series, make it to have the New function being more suitable as and removing high endotoxin absorbent in blood.
Content of the present invention: be embed metallic element X in the carbochain of cancellated styrene-divinyl benzene resin skeleton, its structural formula is C-X-C; Wherein C is carbon, and the metallic element X of embedding is ferric iron element or trivalent aluminium element, and its structural formula is C-Fe-C or C-Al-C; Wherein the 3rd price of iron Fe or aluminium Al is avtive spot Y; Strong and weak according to the ripple alive of element, Y site can be element F(fluorine successively) or Elements C l (chlorine) or element B r(bromine) or I(iodine); There is OH-(hydroxyl) time, also can be OH-; Or there is the functional group of contraposition valence state.
The pore diameter range of the polystyrene new construction resin adopted can be 0-200nm, and pore volume and specific area are not limit; The Y site of the trivalent metallic element embedded in its skeleton is by OH-occupy-place and/or by the occupy-place of monose loop chain and/or by the functional group occupy-place with contraposition valence state; Its purposes is used as Medical Adsorbents, for blood perfusion device; Or be used as oral resin sorbent; By Peripheral Circulation system or gi system, adsorption removal endotoxin material wherein.
Resin aperture is prepared when resin polymerization reacts, relevant with the pore-foaming agent material adopted.The inventive method, when participating in insertion reaction with metallic catalyst, has dilating effect to resin aperture.According to the needs that adsorption removal endotoxin material clinical diagnosis wherein proposes, can the new construction product of medical phenylethylene resin series according to its pore diameter range, do following differentiation: the aperture 0-40nm of the polystyrene new construction resin of employing, resin wherein containing 20-40nm aperture is not less than 60%, and/or aperture 0-60nm, the resin wherein containing 40-60nm aperture is not less than 60%.
When making adsorbent for blood perfusion device and using, can select according to the valence state attribute of the endotoxin material of absorption and particle diameter the resin that there is contraposition valence state functional group and be suitable for aperture, fill blood perfusion device; The mode of filling can be that a kind of resin of pore diameter range loads a tank, and blood perfusion device is according to the material valence state attributive classification in in-built resin aperture and Y site; Or according to the direction arrangement flowed through along blood, the large resin filling in aperture is at upstream position; Be loaded in perfusion device according to the order layering that aperture is descending is mixed, and according to the material valence state delamination classification that the element or functional group that occupy Y point have.
Use for doing oral adsorbent agent, the resin of the different valence state material function that has with Y site group and different pore size is distinguished or hybrid packed in medicinal spansule in proportion.
In such use embodiment of the present invention, the pore diameter range of resin is from " 0 ", and refer to that aperture is " 0 ", namely resin particle does not have hole.But in a perfusion device, the gap between resin particle also can be regarded as in " aperture ", then " aperture " even should cannot measure concrete data, it perhaps can be very large, the aperture that serious offense resin particle can have.
Also any restriction is not done to " pore volume " and " specific area " in such use embodiment.Because for macroporous absorbent resin, the most important condition that restriction adsorbed material enters resin voids is aperture.After aperture is determined, pore volume and specific area are proportional with Adsorbent rate respectively.And adsorption rate and aperture, proportionate relationship between pore volume and specific area are more statistics contents, not there is disruptive technology invention meaning of the present invention.
In a word, the present invention is used in blood perfusion device He in sampler makes adsorbent for removing high endotoxic phenylethylene resin series adsorbent new construction product in blood, due to the existence of avtive spot Y point, can with high endotoxin material in its polarity adsorption function absorption blood; And can be occupied by monose loop chain due to Y point, in high endotoxin material composition surface have glycan molecule, glycoprotein molecule can because of compatibility docile wound on it.
Resin of the present invention to comprise high endotoxemia, septicopyemia crush syndrome blood samples of patients in Small molecular, Middle molecule and large molecule endotoxin material have and well remove and suction-operated.Effectively can rescue, alleviate and cure crush syndrome patient, patients with sepsis.
Naval stores new construction of the present invention all never sees the report of any open source literature before this, is unprecedented technical innovation in this area, compared with prior art has outstanding substantive distinguishing features.
The new construction product of phenylethylene resin series of the present invention uses as adsorbent in blood perfusion device, and removing high endotoxic adsorption effect in blood and be verified in test, is also do not report at the resin sorbent of prior art; Do not remove endotoxic effective ways in blood in prior art, the present invention has significant progress than prior art.
Claims (6)
1. for removing high endotoxic phenylethylene resin series adsorbent new construction product in blood, it is characterized in that: be modified phenylethylene-divinylbenzene macroporous absorbent resin, the carbochain of cancellated styrene-divinyl benzene resin skeleton embeds metallic element X, and its structural formula is C-X-C; Wherein C is carbon; The metallic element X that the carbochain of cancellated styrene-divinyl benzene resin skeleton embeds be ferric iron element or trivalent aluminium element time, its structural formula is C-Fe-C or C-Al-C; Wherein the 3rd price of iron Fe or aluminium Al is avtive spot Y; Strong and weak according to the ripple alive of element, Y site can be element F(fluorine successively) or Elements C l (chlorine) or element B r(bromine) or I(iodine); There is OH-(hydroxyl) time, also can be OH-; Or there is the functional group of contraposition valence state.
2. as claimed in claim 1 for removing high endotoxic phenylethylene resin series adsorbent new construction product in blood, it is characterized in that: the aperture 0-200nm of the polystyrene new construction resin of employing, pore volume and specific area are not limit; The Y point of the trivalent metallic element embedded in its carbochain is by OH-occupy-place and/or by the occupy-place of monose loop chain and/or by the functional group occupy-place with contraposition valence state; Its purposes is used as Medical Adsorbents, for blood perfusion device adsorbent; Or be used as oral resin sorbent; By Peripheral Circulation system or the gi system adsorption removal wherein endotoxin material of particle diameter in resin pore diameter range.
3. as claimed in claim 2 for removing high endotoxic phenylethylene resin series adsorbent new construction product in blood, it is characterized in that: the aperture 0-40nm of the polystyrene new construction resin of employing, the resin wherein containing 20-40nm particle diameter is not less than 60%.
4. as claimed in claim 2 for removing high endotoxic phenylethylene resin series adsorbent new construction product in blood, it is characterized in that: the aperture 0-60nm of the polystyrene new construction resin of employing, the resin wherein containing 40-60nm particle diameter is not less than 60%.
5. as described in claim 2,3,4 for removing high endotoxic phenylethylene resin series adsorbent new construction product in blood, it is characterized in that: when making adsorbent for blood perfusion device and using, can select according to the valence state attribute of virulence factor of absorption and particle diameter and there is contraposition valence state functional group, and the resin being suitable for aperture is to fill blood perfusion device; The mode of filling can be that a kind of resin of pore diameter range loads a tank, and blood perfusion device is according to the material valence state attributive classification in in-built resin aperture and Y site; Or according to the direction arrangement flowed through along blood, the large resin filling in aperture is at upstream position; Be loaded in perfusion device according to the order layering that aperture is descending is mixed, and according to the material valence state delamination classification that the element or functional group that occupy Y point have.
6. as claimed in claim 2 for removing high endotoxic phenylethylene resin series adsorbent new construction product in blood, it is characterized in that: use for doing oral adsorbent agent, the different resin valence state attribute that different pore size and Y point have, respectively or hybrid packed in medicinal spansule in proportion.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310347458.XA CN103483487B (en) | 2013-08-01 | 2013-08-12 | Novel structure product, preparation method and use of styrenic resin |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310347458.XA Division CN103483487B (en) | 2013-08-01 | 2013-08-12 | Novel structure product, preparation method and use of styrenic resin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104667897A true CN104667897A (en) | 2015-06-03 |
| CN104667897B CN104667897B (en) | 2016-03-02 |
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Family Applications (10)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510120605.9A Active CN104689804B (en) | 2013-08-12 | 2013-08-12 | For adsorbing the phenylethylene resin series of AIDS virus molecule in blood |
| CN201510291602.1A Active CN104941607B (en) | 2013-08-12 | 2013-08-12 | Styrene resin adsorption agent for clearing high beta2 microglobulin in blood |
| CN201510120761.5A Active CN104667897B (en) | 2013-08-12 | 2013-08-12 | For adsorbing high endotoxic phenylethylene resin series in blood |
| CN201510291618.2A Pending CN104922147A (en) | 2013-08-12 | 2013-08-12 | New structure medical resin for eliminating high cholesterol |
| CN201510156544.1A Active CN104815628B (en) | 2013-08-12 | 2013-08-12 | A kind of purposes of modified phenylethylene-divinylbenzene macroporous absorbent resin |
| CN201510291587.0A Pending CN104887699A (en) | 2013-08-12 | 2013-08-12 | Medical adsorptive resin for clearing away factors blocking nerve conduction |
| CN201510120428.4A Active CN104689803B (en) | 2013-08-12 | 2013-08-12 | For adsorbing the phenylethylene resin series of hepatitis viruse in blood |
| CN201510291617.8A Pending CN104857015A (en) | 2013-08-12 | 2013-08-12 | Styrene type novel-structure adsorption resin for de-addiction and detoxification |
| CN201510291616.3A Pending CN104887700A (en) | 2013-08-12 | 2013-08-12 | Medical adsorptive resin for eliminating syphilis and sexual disease pathogenic factors |
| CN201510291604.0A Active CN104923185B (en) | 2013-08-12 | 2013-08-12 | Medical polymeric adsorbent for removing H N macromoleculars virus |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510120605.9A Active CN104689804B (en) | 2013-08-12 | 2013-08-12 | For adsorbing the phenylethylene resin series of AIDS virus molecule in blood |
| CN201510291602.1A Active CN104941607B (en) | 2013-08-12 | 2013-08-12 | Styrene resin adsorption agent for clearing high beta2 microglobulin in blood |
Family Applications After (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510291618.2A Pending CN104922147A (en) | 2013-08-12 | 2013-08-12 | New structure medical resin for eliminating high cholesterol |
| CN201510156544.1A Active CN104815628B (en) | 2013-08-12 | 2013-08-12 | A kind of purposes of modified phenylethylene-divinylbenzene macroporous absorbent resin |
| CN201510291587.0A Pending CN104887699A (en) | 2013-08-12 | 2013-08-12 | Medical adsorptive resin for clearing away factors blocking nerve conduction |
| CN201510120428.4A Active CN104689803B (en) | 2013-08-12 | 2013-08-12 | For adsorbing the phenylethylene resin series of hepatitis viruse in blood |
| CN201510291617.8A Pending CN104857015A (en) | 2013-08-12 | 2013-08-12 | Styrene type novel-structure adsorption resin for de-addiction and detoxification |
| CN201510291616.3A Pending CN104887700A (en) | 2013-08-12 | 2013-08-12 | Medical adsorptive resin for eliminating syphilis and sexual disease pathogenic factors |
| CN201510291604.0A Active CN104923185B (en) | 2013-08-12 | 2013-08-12 | Medical polymeric adsorbent for removing H N macromoleculars virus |
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| CN (10) | CN104689804B (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107789691A (en) * | 2016-09-07 | 2018-03-13 | 天津市阳权医疗器械有限公司 | It is exclusively used in treating the disposable blood perfusion device of endotoxemia |
| CN108031454A (en) * | 2017-12-19 | 2018-05-15 | 陈荣胜 | Possesses blood-purifying adsorbing agent of physics specific selectivity and preparation method thereof |
| JP2018522943A (en) * | 2015-07-09 | 2018-08-16 | 杰 于 | Adsorption resin powder for micro / nano medical |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104689804B (en) * | 2013-08-12 | 2016-03-02 | 天津市阳权医疗器械有限公司 | For adsorbing the phenylethylene resin series of AIDS virus molecule in blood |
| CN113262762B (en) * | 2021-05-06 | 2023-04-21 | 西安蓝深新材料科技股份有限公司 | Adsorption material for blood perfusion and preparation method thereof |
| CN114085829B (en) * | 2021-11-18 | 2023-08-11 | 军事科学院军事医学研究院环境医学与作业医学研究所 | Efficient enrichment method for viruses in environmental medium |
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| CN102335465A (en) * | 2010-07-27 | 2012-02-01 | 天津市阳权医疗器械有限公司 | Blood perfusion device for treating uremia |
| CN102335466A (en) * | 2010-07-27 | 2012-02-01 | 天津市阳权医疗器械有限公司 | Blood perfusion device for treating hypertension |
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| CN103483487B (en) * | 2013-08-01 | 2015-06-24 | 天津市阳权医疗器械有限公司 | Novel structure product, preparation method and use of styrenic resin |
| CN104689804B (en) * | 2013-08-12 | 2016-03-02 | 天津市阳权医疗器械有限公司 | For adsorbing the phenylethylene resin series of AIDS virus molecule in blood |
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2013
- 2013-08-12 CN CN201510120605.9A patent/CN104689804B/en active Active
- 2013-08-12 CN CN201510291602.1A patent/CN104941607B/en active Active
- 2013-08-12 CN CN201510120761.5A patent/CN104667897B/en active Active
- 2013-08-12 CN CN201510291618.2A patent/CN104922147A/en active Pending
- 2013-08-12 CN CN201510156544.1A patent/CN104815628B/en active Active
- 2013-08-12 CN CN201510291587.0A patent/CN104887699A/en active Pending
- 2013-08-12 CN CN201510120428.4A patent/CN104689803B/en active Active
- 2013-08-12 CN CN201510291617.8A patent/CN104857015A/en active Pending
- 2013-08-12 CN CN201510291616.3A patent/CN104887700A/en active Pending
- 2013-08-12 CN CN201510291604.0A patent/CN104923185B/en active Active
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| US4383088A (en) * | 1982-02-04 | 1983-05-10 | Combustion Engineering, Inc. | Organic polymer layered dichalcogenides |
| CN101912770A (en) * | 2010-09-03 | 2010-12-15 | 中国科学院长春应用化学研究所 | Polymeric adsorbent and preparation method thereof |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2018522943A (en) * | 2015-07-09 | 2018-08-16 | 杰 于 | Adsorption resin powder for micro / nano medical |
| EP3321296A4 (en) * | 2015-07-09 | 2018-12-26 | Jie Yu | Micro-nano medical adsorbent resin powder material |
| CN107789691A (en) * | 2016-09-07 | 2018-03-13 | 天津市阳权医疗器械有限公司 | It is exclusively used in treating the disposable blood perfusion device of endotoxemia |
| CN108031454A (en) * | 2017-12-19 | 2018-05-15 | 陈荣胜 | Possesses blood-purifying adsorbing agent of physics specific selectivity and preparation method thereof |
| CN108031454B (en) * | 2017-12-19 | 2021-08-13 | 陈荣胜 | Blood purification adsorbent with physical specificity selectivity and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104815628B (en) | 2017-08-11 |
| CN104815628A (en) | 2015-08-05 |
| CN104887699A (en) | 2015-09-09 |
| CN104689804A (en) | 2015-06-10 |
| CN104941607A (en) | 2015-09-30 |
| CN104923185B (en) | 2017-10-24 |
| CN104689803B (en) | 2016-03-02 |
| CN104857015A (en) | 2015-08-26 |
| CN104689804B (en) | 2016-03-02 |
| CN104887700A (en) | 2015-09-09 |
| CN104667897B (en) | 2016-03-02 |
| CN104923185A (en) | 2015-09-23 |
| CN104922147A (en) | 2015-09-23 |
| CN104689803A (en) | 2015-06-10 |
| CN104941607B (en) | 2017-02-01 |
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Effective date of registration: 20190807 Address after: 264210 No. 1 Weigao Road, Chucun Town, Weihai Torch High-tech Industrial Development Zone, Shandong Province Patentee after: Weihai Weigaoyangquan Biological Co., Ltd. Address before: 300222 north side of outer ring road, East Mountain Road, Jinnan District, Tianjin Patentee before: Tianjin Yangquan Medical Devices Co., Ltd. |
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