CN104644955A - Traditional Chinese medicine composite for treating dysmenorrhea and preparation method of composite - Google Patents
Traditional Chinese medicine composite for treating dysmenorrhea and preparation method of composite Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composite for treating dysmenorrhea. The traditional Chinese medicine composite comprises salvia miltiorrhiza, rhizoma corydalis, rhizoma cyperi, radix linderae, pericarpium citri reticulatae viride, radix bupleuri, curcuma aromatica and cuscuta chinensis, wherein salvia miltiorrhiza and rhizoma corydalis have effects of promoting a blood circulation, restoring a menstrual flow and removing blood stasis; combined use of radix linderae and rhizoma cyperi has a good effect on a patient with swelling pain all over a body and stagnation of qi and blood; pericarpium citri reticulatae viride, radix bupleuri, curcuma aromatica and cuscuta chinensis have effects of soothing a liver, tonifying a kidney, regulating qi, promoting the blood circulation, resolving depression and clearing away the heart-fire. The traditional Chinese medicine composite has effects of promoting the blood circulation to arrest the pain and conditioning a mind and a body, so that the purpose of treating both symptoms and root causes is achieved. The traditional Chinese medicine composition is small in taking dosage, convenient to take, high in bioavailability, convenient to carry, accurate in ration and stable in quality, and can be absorbed quickly.
Description
Technical field
The invention belongs to pharmaceuticals application and preparing technical field, be specifically related to a kind of Chinese medicine composition for the treatment of dysmenorrhea and preparation method thereof.
Background technology
Dysmenorrhea refers to that women is in menstrual period and front and back thereof, occurs lower abdomen or flank pain, even pain and waist sacrum, and send out with menstrual cycle, severe patient can accompany nausea and vomiting, deadly cold hand and foot, even faints.
Dysmenorrhea is common gynecological disease and frequently-occurring disease, the cause of disease is many, pathogenesis is complicated, repeatability is large, treat thorny, especially Unmarried Females and menarche maiden more general, show as gynecologic menstrual or front and back of passing through, mostly start from menstrual onset or a few hours before vaginal hemorrhage, periodically there is hypogastric region distending pain, cold type of pain, causalgia, twinge, dull pain, pendant pain, angor, spasmic pain, lancinating pain, pain is extended down to sacrum lower back, even relate to thigh and foot, last 1/2 ~ 2 hour, painful area is many at hypogastric region, severe one can be radiated to front side in lumbosacral region or stock, about there is more than 50% patient with General Symptoms, about continue 12 ~ 24 hours, fade away after menses outflow is unimpeded, also even have 2 ~ 3 days persons that need lie in bed, the height of its morbidity, scope is wide, cycle is near, painful big, the working and learning of numerous women are had a strong impact on, reduce the quality of life.
The Western medicine for the treatment of dysmenorrhea mainly contains following several: hormone medicine, PGSI, beta-receptor analeptic, calcium channel blocker, gossypol, analgesic etc.
Above-mentioned Western medicine has dependency mostly, and long-term taking upsets endocrine, and treatment dysmenorrhea also has a lot of Chinese patent medicine now, but some has side effect, as Ramulus Cinnamomi Poria pill, stomach discomfort can be caused even to have a stomachache, caused by principle active component cinnamic aldehyde after taking.
Summary of the invention
Object of the present invention is just to provide a kind of scientific formula, taking convenience, the Chinese medicine composition being used for the treatment of dysmenorrhea had no side effect.
The present invention is achieved through the following technical solutions:
Treat a Chinese medicine composition for dysmenorrhea, comprise following raw material by weight: Radix Salviae Miltiorrhizae 10-40 part, Rhizoma Corydalis 9-18 part, Rhizoma Cyperi 9-15 part, Radix Linderae 5-20 part, Pericarpium Citri Reticulatae Viride 5-25 part, Radix Bupleuri 9-15 part, Radix Curcumae 10-25 part, Semen Cuscutae 9-25 part.
Further, following raw material is comprised by weight: Radix Salviae Miltiorrhizae 15-30 part, Rhizoma Corydalis 12-17 part, Rhizoma Cyperi 10-13 part, Radix Linderae 7-15 part, Pericarpium Citri Reticulatae Viride 6-15 part, Radix Bupleuri 9-12 part, Radix Curcumae 12-20 part, Semen Cuscutae 10-18 part.
Optimal technical scheme is: Radix Salviae Miltiorrhizae 25 parts, Rhizoma Corydalis 15 parts, Rhizoma Cyperi 12 parts, the Radix Linderae 10 parts, 9 parts, Pericarpium Citri Reticulatae Viride, Radix Bupleuri 10 parts, Radix Curcumae 15 parts, Semen Cuscutae 15 parts.
Present invention also offers the preparation method of the Chinese medicine composition of this treatment dysmenorrhea, it comprises the following steps simultaneously:
(1) take raw material by weight, add the soak by water three times of raw material 10 times of weight, each one hour at every turn, collect medical filtration, by filtrations afterwards filtrate temperature be down to 40 ~ 50 DEG C and be condensed into clear paste;
(2) being added by ethanol in the clear paste that step (1) obtains makes alcohol content reach 60%, staticly settles 48 hours, filters, and reclaims ethanol, obtains whole filtrate;
(3) by concentrated, dry for whole for step (2) gained filtrate heating, pulverizing, cross 200 mesh sieves, obtain medicated powder;
(4) other dosage form pharmaceutically acceptable is directly packed or made to the medicated powder that step (3) obtains.
Further, described dosage form comprises capsule, tablet, pill, electuary, powder and granule.
In the present invention, pharmacology, effect of each raw material are as follows:
1, Radix Salviae Miltiorrhizae: be the dry root and rhizome of labiate Radix Salviae Miltiorrhizae Salvia miltiorrhiza Bge..
Meridian distribution of property and flavor: bitter, is slightly cold.GUIXIN, Liver Channel.
Function cures mainly: stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, and clear away heart-fire relieving restlessness.For menoxenia, amenorrhea dysmenorrhea, note of the ancient Chinese abdominal mass is gathered, breast ventral spine pain, pyretic arthralgia pain, and skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris.
2, Rhizoma Corydalis
Meridian distribution of property and flavor: pungent; Bitter; Temperature; Nontoxic.Return liver; Stomach; The heart; Lung; Spleen channel.
Function cures mainly: invigorate blood circulation; Dissipating blood stasis; Regulate the flow of vital energy; Pain relieving.The all pains of main trusted subordinate's waist knee joint; Menoxenia; Lump in the abdomen; Metrorrhagia; Puerperal blood faints; Lochiorrhea; Traumatic injury.
3, Rhizoma Cyperi: be the dry rhizome of sedge dried tuber Cyperus rotundus L..
Meridian distribution of property and flavor: pungent, micro-hardship, micro-sweet is flat.Return liver, spleen, tri-jiao channel.
Function cures mainly: promoting QI circulation for relieving depression, menstruction regulating and pain relieving.For stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, breast gastral cavity painful abdominal mass is vexed, and colic of cold type is suffered from abdominal pain, distending pain of the breast, menoxenia, amenorrhea dysmenorrhea.
4, the Radix Linderae: be the root of the dicotyledon medicine canella Radix Linderae.
Meridian distribution of property and flavor: pungent, temperature.Enter spleen, lung, kidney, urinary bladder channel.
Function cures mainly: pleasant, dissipating depression of QI, cold expelling, pain relieving.Control QI rising in reverse order chest and abdomen swelling and pain, dyspepsia does not disappear, and food is told in regurgitation, colic of cold type, beriberi, frequent micturition.
5, Pericarpium Citri Reticulatae Viride: be rutaceae orange Citrus reticulata Blanco and the dry young fruit of variety thereof or the peel of immature fruit.
Function cures mainly: soothing the liver dispelling the stagnated QI; Removing food stagnancyization is stagnant.The distending pain over the hypochondrium of main stagnation of QI due to depression of the liver; Distending pain of the breast; Nodule in the breast; Acute mastitis; Hernia pain; The epigastric distending pain of stagnation of QI due to dyspepsia; And qi depression to blood stasis lump in the abdomen extremely; Chronic malaria addiction block.
Pharmacological action: cloperastine of dispelling is breathed heavily; Suppress the smooth muscle contraction such as uterus, intestinal, bronchus; Boosting, shock.
6, Radix Bupleuri: be the dry root of umbelliferae bupleurum (Bupleurum chinense DC.) or Radix Bupeuri Scorzonerfolii. (Bupleurum scorzonerifolium Willd.).Different by character, practise respectively and claim Radix Bupleuri and Radix Bupleuri Scorzonerifolii.
Meridian distribution of property and flavor: bitter, cool.Enter liver, gallbladder meridian.
Function cures mainly: reconciling superficies and interior, soothing the liver, yang invigorating.Control alternate attack of chill and fever, fullness in the chest and hypochondriac pain, bitter taste is deaf, headache and dizziness, malaria, lower sharp proctoptosis, menoxenia, uterine prolapse.
7, Radix Curcumae: be Yu Jing again.Nature and flavor are pungent, bitter, cold.Function is promoting blood circulation and stopping pain, promoting QI circulation for relieving depression, and removing heat from blood clears away heart-fire, promoting the function of the gallbladder to alleviate jaundice.
8, Semen Cuscutae: be the mature seed of convolvulus cuscuta plant and Cuscuta australis etc.
Meridian distribution of property and flavor: abnormal smells from the patient is pungent, sweet, flat nontoxic.Return liver; Kidney; Spleen channel
Function with cure mainly: the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity.The waist knee joint muscles and bones being applicable to deficiency of the liver and kindey is ached, the diseases such as legs and feet weakness, impotence and seminal emission, crazy talk, frequent micturition, dripping urination, dizziness and blurred vision, blurring of vision, Hiccough and deaf and women's leukorrhagia, habitual abortion.
Advantage of the present invention is: drug regimen involved in the present invention has effect of blood circulation promoting and blood stasis dispelling, wherein Radix Salviae Miltiorrhizae, Rhizoma Corydalis for invigorating blood circulation, stimulating the menstrual flow, the medicine of blood stasis dispelling, " not bitterly, general rule is not bitterly for general rule ".Modern pharmacological research shows: Radix Salviae Miltiorrhizae blood circulation promoting and blood stasis dispelling active component mainly contains the compounds such as danshensu, rosmarinic acid, TANSHINONES, and in Rhizoma Corydalis, Corydaline, B prime, Chou prime all have the analgesic activity shown.And be the strongest with B prime, Chou prime, A prime is taken second place.And C prime also has obvious analgesic activity, but weak compared with morphine.The Radix Linderae and Rhizoma Cyperi are share name " Rhizoma Cyperi fall apart " (" careful vegetarian posthumous papers "), and to distending pain from head to foot, coagulation of QI-blood person has good effect, and because of in Radix Linderae energy gas and blood, Rhizoma Cyperi is apt to circulation of qi promoting in blood, mutually auxiliary more evident.Pericarpium Citri Reticulatae Viride, Radix Bupleuri, Radix Curcumae, Semen Cuscutae Shugan Bushen, vital energy regualting and blood circulation-promoting, resolving depression clear away heart-fire.This composition of medicine is while promoting blood circulation and stopping pain, and conditioning body and mind, to reach the object for the treatment of both the principal and secondary aspects of a disease.
Chinese medicine administered in combination dosage of the present invention is little, taking convenience, absorption is fast, bioavailability is high, easy to carry, quantitatively accurately, steady quality.
Detailed description of the invention
In order to the object of the present invention of understanding clearly, technical scheme and beneficial effect, below the present invention is described further, but not by protection scope of the present invention limit in the examples below.
Embodiment 1
1, medicine composition: Radix Salviae Miltiorrhizae 10 parts, Rhizoma Corydalis 9 parts, Rhizoma Cyperi 9 parts, the Radix Linderae 5 parts, 5 parts, Pericarpium Citri Reticulatae Viride, Radix Bupleuri 9 parts, Radix Curcumae 10 parts, Semen Cuscutae 9 parts.
2, preparation method:
(1) take raw material by weight, add the soak by water three times of raw material 10 times of weight, each one hour at every turn, collect medical filtration, by filtrations afterwards filtrate temperature be down to 40 DEG C and be condensed into clear paste;
(2) being added by ethanol in the clear paste that step (1) obtains makes alcohol content reach 60%, staticly settles 48 hours, filters, and reclaims ethanol, obtains whole filtrate;
(3) by concentrated, dry for whole for step (2) gained filtrate heating, pulverizing, cross 200 mesh sieves, obtain medicated powder;
(4) other dosage form pharmaceutically acceptable is directly packed or made to the medicated powder that step (3) obtains.
(5) granulation of step (4) medicated powder is packaged into the electuary of 6g/ bag.
Embodiment 2
1, medicine composition: Radix Salviae Miltiorrhizae 40 parts, Rhizoma Corydalis 18 parts, Rhizoma Cyperi 15 parts, the Radix Linderae 20 parts, 25 parts, Pericarpium Citri Reticulatae Viride, Radix Bupleuri 15 parts, Radix Curcumae 25 parts, Semen Cuscutae 25 parts.
2, preparation method:
(1) take raw material by weight, add the soak by water three times of raw material 10 times of weight, each one hour at every turn, collect medical filtration, by filtrations afterwards filtrate temperature be down to 50 DEG C and be condensed into clear paste;
(2) being added by ethanol in the clear paste that step (1) obtains makes alcohol content reach 60%, staticly settles 48 hours, filters, and reclaims ethanol, obtains whole filtrate;
(3) by concentrated, dry for whole for step (2) gained filtrate heating, pulverizing, cross 200 mesh sieves, obtain medicated powder;
(4) other dosage form pharmaceutically acceptable is directly packed or made to the medicated powder that step (3) obtains.
(5) granulation of step (4) medicated powder is packaged into the electuary of 6g/ bag.
Embodiment 3
1, medicine composition: Radix Salviae Miltiorrhizae 15 parts, Rhizoma Corydalis 12 parts, Rhizoma Cyperi 10 parts, the Radix Linderae 7 parts, 6 parts, Pericarpium Citri Reticulatae Viride, Radix Bupleuri 9 parts, Radix Curcumae 12 parts, Semen Cuscutae 10 parts.
2, preparation method:
(1) take raw material by weight, add the soak by water three times of raw material 10 times of weight, each one hour at every turn, collect medical filtration, by filtrations afterwards filtrate temperature be down to 45 DEG C and be condensed into clear paste;
(2) being added by ethanol in the clear paste that step (1) obtains makes alcohol content reach 60%, staticly settles 48 hours, filters, and reclaims ethanol, obtains whole filtrate;
(3) by concentrated, dry for whole for step (2) gained filtrate heating, pulverizing, cross 200 mesh sieves, obtain medicated powder;
(4) other dosage form pharmaceutically acceptable is directly packed or made to the medicated powder that step (3) obtains.
(5) granulation of step (4) medicated powder is packaged into the electuary of 6g/ bag.
Embodiment 4
1, medicine composition: Radix Salviae Miltiorrhizae 30 parts, Rhizoma Corydalis 17 parts, Rhizoma Cyperi 13 parts, the Radix Linderae 15 parts, 15 parts, Pericarpium Citri Reticulatae Viride, Radix Bupleuri 12 parts, Radix Curcumae 20 parts, Semen Cuscutae 18 parts.
2, preparation method:
(1) take raw material by weight, add the soak by water three times of raw material 10 times of weight, each one hour at every turn, collect medical filtration, by filtrations afterwards filtrate temperature be down to 45 DEG C and be condensed into clear paste;
(2) being added by ethanol in the clear paste that step (1) obtains makes alcohol content reach 60%, staticly settles 48 hours, filters, and reclaims ethanol, obtains whole filtrate;
(3) by concentrated, dry for whole for step (2) gained filtrate heating, pulverizing, cross 200 mesh sieves, obtain medicated powder;
(4) other dosage form pharmaceutically acceptable is directly packed or made to the medicated powder that step (3) obtains.
(5) granulation of step (4) medicated powder is packaged into the electuary of 6g/ bag.
Embodiment 5
1, medicine composition: Radix Salviae Miltiorrhizae 25 parts, Rhizoma Corydalis 15 parts, Rhizoma Cyperi 12 parts, the Radix Linderae 10 parts, 9 parts, Pericarpium Citri Reticulatae Viride, Radix Bupleuri 10 parts, Radix Curcumae 15 parts, Semen Cuscutae 15 parts.
2, preparation method:
(1) take raw material by weight, add the soak by water three times of raw material 10 times of weight, each one hour at every turn, collect medical filtration, by filtrations afterwards filtrate temperature be down to 45 DEG C and be condensed into clear paste;
(2) being added by ethanol in the clear paste that step (1) obtains makes alcohol content reach 60%, staticly settles 48 hours, filters, and reclaims ethanol, obtains whole filtrate;
(3) by concentrated, dry for whole for step (2) gained filtrate heating, pulverizing, cross 200 mesh sieves, obtain medicated powder;
(4) other dosage form pharmaceutically acceptable is directly packed or made to the medicated powder that step (3) obtains.
(5) granulation of step (4) medicated powder is packaged into the electuary of 6g/ bag.
Clinical laboratory data
1, dysmenorrhea effect observation is treated
1.1 select dysmenorrhea persons 83 example, serve on observe the curative effect after 3 menstrual cycle.
1.2 Therapeutic Method
Instructions of taking: first three sky of passing through starts to take, and serve on three days, each one bag, every day three times.If still pain when passing through, then add one day.Take three menstrual cycle continuously.(remarks: electuary obtained in embodiment 1-5 selected at random by electuary)
1.3 curative effect determinate standard
(1) cure: dysmenorrhea symptom all disappears, and cuts and does not recur half a year.
(2) take a turn for the better: symptom has certain improvement.
(3) invalid: subjective symptoms and sign without any improvement.
1.4 result
In therapeutic process, use the present composition to treat the different patient of 83 routine diseases, result cures 51 examples, and take a turn for the better 30 examples, invalid 2 examples, total effective rate 97.59%.In use, all there is not the untoward reaction such as allergy or poison pair in all patients.
1.5 conclusion
Modern medicine is thought, dysmenorrhea is generally caused by endocrine, uterus and Neuropsychical facto three reasons.The traditional Chinese medical science is thought, dysmenorrhea is because the liver pulse is not smooth, qi-movement disturbance, the disharmony between QI and blood that arrives in stasis born of the same parents, blockage of main and collateral channels, therefore occurs abdominal pain during menstruation.The present invention, with the legislation of " leading to " word, gets the merit of blood circulation promoting and blood stasis dispelling, depressed liver-energy dispersing and QI regulating, relieving pain of dysmenorrhea.
From this clinical effectiveness, prescription therapeutic dysmenorrhea cure rate of the present invention is high, and relapse rate is low, and toxic and side effects is little, is worthy to be popularized.
Claims (5)
1. treat a Chinese medicine composition for dysmenorrhea, it is characterized in that: comprise following raw material by weight: Radix Salviae Miltiorrhizae 10-40 part, Rhizoma Corydalis 9-18 part, Rhizoma Cyperi 9-15 part, Radix Linderae 5-20 part, Pericarpium Citri Reticulatae Viride 5-25 part, Radix Bupleuri 9-15 part, Radix Curcumae 10-25 part, Semen Cuscutae 9-25 part.
2. a kind of Chinese medicine composition for the treatment of dysmenorrhea according to claim 1, is characterized in that: comprise following raw material by weight: Radix Salviae Miltiorrhizae 15-30 part, Rhizoma Corydalis 12-17 part, Rhizoma Cyperi 10-13 part, Radix Linderae 7-15 part, Pericarpium Citri Reticulatae Viride 6-15 part, Radix Bupleuri 9-12 part, Radix Curcumae 12-20 part, Semen Cuscutae 10-18 part.
3. a kind of Chinese medicine composition for the treatment of dysmenorrhea according to claim 1, is characterized in that: comprise following raw material by weight: Radix Salviae Miltiorrhizae 25 parts, Rhizoma Corydalis 15 parts, Rhizoma Cyperi 12 parts, the Radix Linderae 10 parts, 9 parts, Pericarpium Citri Reticulatae Viride, Radix Bupleuri 10 parts, Radix Curcumae 15 parts, Semen Cuscutae 15 parts.
4. a kind of preparation method for the treatment of the Chinese medicine composition of dysmenorrhea described in the arbitrary claim of claims 1 to 3, is characterized in that: comprise the following steps:
(1) take raw material by weight, add the soak by water three times of raw material 10 times of weight, each one hour at every turn, collect medicine-liquid and filter, by filtrations afterwards filtrate temperature be down to 40 ~ 50 DEG C and be condensed into clear paste;
(2) being added by ethanol in the clear paste that step (1) obtains makes alcohol content reach 60%, staticly settles 48 hours, filters, and reclaims ethanol, obtains whole filtrate;
(3) by concentrated, dry for whole for step (2) gained filtrate heating, pulverizing, cross 200 mesh sieves, obtain medicated powder;
(4) other dosage form pharmaceutically acceptable is directly packed or made to the medicated powder that step (3) obtains.
5. a kind of Chinese medicine composition for the treatment of dysmenorrhea according to claim 4, is characterized in that: described dosage form comprises capsule, tablet, pill, electuary, powder and granule.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101002926A (en) * | 2007-01-08 | 2007-07-25 | 山东泰坤中医药有限公司 | Traditional Chinese medicine for treating menorrhalgia |
| CN102362942A (en) * | 2011-08-24 | 2012-02-29 | 成都绿迪科技有限公司 | Traditional Chinese medicinal formula for treating dysmenorrhoea |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101002926A (en) * | 2007-01-08 | 2007-07-25 | 山东泰坤中医药有限公司 | Traditional Chinese medicine for treating menorrhalgia |
| CN102362942A (en) * | 2011-08-24 | 2012-02-29 | 成都绿迪科技有限公司 | Traditional Chinese medicinal formula for treating dysmenorrhoea |
Non-Patent Citations (3)
| Title |
|---|
| 周建忠等: "痛经证治浅谈", 《中国实用医药》 * |
| 范京国: "活血镇痛汤加味治疗原发性痛经50例", 《实用中医药杂志》 * |
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Denomination of invention: A traditional Chinese medicine composition for treating dysmenorrhea and its preparation method Effective date of registration: 20230224 Granted publication date: 20180313 Pledgee: Heze rural commercial bank Limited by Share Ltd. Pledgor: Shandong tianzhiyou Pharmaceutical Co.,Ltd. Registration number: Y2023980033345 |
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