CN104523445A - Nanoscale emulsion with high transdermal absorbency - Google Patents
Nanoscale emulsion with high transdermal absorbency Download PDFInfo
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Abstract
The invention relates to a nanoscale emulsion with high transdermal absorbency. The nanoscale emulsion contains the following components in parts by weight: 0.01 to 5 parts of salidroside, 0.5 to 20 parts of nonionic surfactant, 1 to 20 parts of phospholipid, 5 to 15 parts of oil and 60 to 90 parts of dispersion medium. Due to the existence of lipid and corneum of the skin, hydrophilic molecules are difficult to pass through the skin barrier to be absorbed by the body. The existing related preparations of salidroside are poor in stability, while according to the invention, the salidroside is wrapped in the phospholipid microcapsule nano emulsion, so that the lipid solubility of the salidroside can be effectively improved, the transdermal absorbency of the salidroside can be improved, and the application of the salidroside in the field of external use of skin can be enhanced. The lipid nanoscale emulsion containing the salidroside is high in enveloping rate, the particle size is less than 150nm, the transdermal absorbency of the salidroside can be promoted, and the nanoscale emulsion is better than that in the prior art.
Description
Technical field
The present invention relates to the preparation of rhodioside, be specifically related to a kind of nanoscale emulsion of high percutaneous absorbability.
Background technology
Rhodioside (Salidroside) is the principle active component of Radix Rhodiolae, modern pharmacology research proves, rhodioside has antifatigue effect, resisting microwave radiation effect, suppresses the health cares such as blood glucose rising, Hardy dwarfing, be widely used in health product, beverage, and in cosmetics.
Rhodioside molecular weight is 300Da, excellent aqueous solubility.Generally speaking, due to the lipid and cuticular existence of skin, hydrophilic molecule is difficult to be absorbed by body by skin barrier.By technological means such as Emulsions, hydrophilic molecule is wrapped in the amphipathic systems such as Emulsion, significantly can strengthens the bioavailability of hydrophilic molecules.
Nanoemulsions (Nanoemulsion) is also known as microemulsion (microemulsion), be be made up according to appropriate proportioning of aqueous phase, oil phase, surfactant and cosurfactant, there is the transparent or semitransparent system that low viscosity, isotropic thermodynamics and kinetics are stable.Its advantage is the dissolubility increasing insoluble drug, and raising medicine stability and bioavailability, many insoluble drugs have slow release and targeting after making nano-emulsion; Nano-emulsion good biocompatibility, biodegradable, therefore, it is used as fat-soluble medicine and the carrier to water sensitive medicine, can reduce zest and the toxic and side effects of medicine, Thermodynamically stable, be long placed in not stratified, not breakdown of emulsion.
But nano-emulsion itself is a thermodynamic instability system, change prescription or condition of storage for specific unstable mechanism, the stability of nano-emulsion could be improved and promote its application in practice.
CN201210434701.7 (CN102871936A) provides a kind of nano-carrier of load Radix Rhodiolae extract, comprise by its weight ratio: Radix Rhodiolae extract 0.5-3%, solvent 20-30%, emulsifying agent 40-50%, matrix material 18-35%, wherein matrix material is the solidliquid mixture of liquid lipoid material and solid lipid material, emulsifier package draws together water-in-oil emulsifier and oil-water emulsifiers, and to have write water-in-oil emulsifier exactly in claim 4,5 be one or both in Polyethylene Glycol-30-dimerization hydroxy stearic acid ester, polyglycereol-3 diisopstearate; Oil-water emulsifiers is one or more in polyoxyethylene lauryl ether, Tween 80.Although the main component in Radix Rhodiolae extract is rhodioside, also containing other compositions in this extract, the nano-emulsion character causing this invention to provide is unstable.
Therefore, need to provide a kind of Transdermal absorption effective, and the nano-emulsion preparation of good stability.
Summary of the invention
The object of this invention is to provide a kind of nanoscale emulsion of high percutaneous absorbability.
The first object of the present invention is to provide a kind of nanoscale emulsion of high percutaneous absorbability, and it is made up of rhodioside, non-ionic surface active agent, phospholipid, oil and disperse medium.
Concrete, described nanoscale emulsion is grouped into by the one-tenth of following weight portion: rhodioside 0.01-5 part, non-ionic surface active agent 0.5-20 part, phosphatidase 1-20 parts, oily 5-15 part and disperse medium 60-90 part.
In above-mentioned nano-emulsion:
Described phospholipid is soybean lecithin or Ovum Gallus domesticus Flavus lecithin, preferably soya lecithin;
Described oil is one or both of soybean oil, caprylic/capric glyceride, safflower oil or olive oil, is preferably caprylic/capric glyceride;
Described non-ionic surface active agent is more than four kinds in sorbester p18, sorbester p17, polyglycerol monooleate, Tween 80, polyoxyethylene castor oil or Polyethylene Glycol caprylic/capric glyceride;
Described disperse medium is one or both in water, glycerol or propylene glycol.
Preferred version of the present invention, described nanoscale emulsion is grouped into by the one-tenth of following weight portion: rhodioside 0.1-2 part, sorbester p17 0-1.5 part, polyglycerol monooleate 0.5-3.5 part, Tween 80 0.5-5 part, polyoxyethylene castor oil 0-5 part, Polyethylene Glycol caprylic/capric 0-5 part, phosphatidase 3 .5-10 part, caprylic/capric glyceride 5-15 part, glycerol 40-80 part and water 5-20 part.
Further preferably, described nanoscale emulsion is grouped into by the one-tenth of following weight portion: rhodioside 0.1 part, polyglycerol monooleate 0.5 part, Tween 80 0.5 part, polyoxyethylene castor oil 0.5 part, Polyethylene Glycol caprylic/capric glyceride 0.5 part, phosphatidase 3 .5 part, caprylic/capric glyceride 5 parts, glycerol 69.4 parts and 20 parts, water.
Further preferably, described nanoscale emulsion is grouped into by the one-tenth of following weight portion: rhodioside 0.5 part, sorbester p17 0.5 part, polyglycerol monooleate 1.5 parts, Tween 80 1 part, polyoxyethylene castor oil 2 parts, phosphatidase 5 part, caprylic/capric glyceride 10 parts, glycerol 64.5 parts and 15 parts, water.
Further preferably (transdermal effect is better), described nanoscale emulsion is grouped into by the one-tenth of following weight portion: rhodioside 1-2 part, sorbester p17 1-1.5 part, polyglycerol monooleate 1.8-2.5 part, Tween 80 2-5 part, Polyethylene Glycol caprylic/capric glyceride 1-3 part, phosphatidase 5-10 parts, caprylic/capric glyceride 10-15 part, glycerol 58-65 part and water 10-15 part.
Further preferably (transdermal effect is best), described nanoscale emulsion is grouped into by the one-tenth of following weight portion: rhodioside 2 parts, sorbester p17 1.5 parts, polyglycerol monooleate 2.5 parts, Tween 80 5 parts, Polyethylene Glycol caprylic/capric glyceride 1 part, phosphatidase 10 part, caprylic/capric glyceride 15 parts, glycerol 58 parts and 15 parts, water.
Another object of the present invention is to provide the preparation method of above-mentioned nanoscale emulsion, and the method comprises the steps:
1) respectively phospholipid, rhodioside are dissolved in chloroform-hexane solution (chloroform: normal hexane, 5:7, v/v), with in distilled water, after stirring, by two solution mixing, and supersound process, gained Emulsion, through lyophilization process, obtains rhodioside-phosphatide complexes;
2) by step 1) gained rhodioside-phosphatide complexes, oil, non-ionic surface active agent mixing, high speed shear under 8000-12000rpm condition, without the visible solid content of naked eyes to system;
3) disperse medium is added step 2) product, high speed shear under 8000-12000rpm condition, obtains colostrum, and colostrum is through high pressure homogenizer process, and pressure 800-2000bar used, cycle-index 5-10 time, obtains transparent clear shape nanoscale emulsion.
Present invention also offers above-mentioned nanoscale emulsion and prepare the application in antioxidative cosmetics.
Nanoscale emulsion provided by the invention has the following advantages:
1, the nano-emulsion preparation of existing rhodioside, poor stability, and nano-emulsion preparation provided by the invention, by rhodioside and phospholipid, oil, non-ionic surface active agent, disperse medium are carried out suitable proportioning, reasonable mixture ratio, especially select multiple non-ionic surface active agent, avoid single surfactant and can not be fused to shortcoming in rhodioside completely, the nanoscale emulsion good stability of final combination.
2, preparation method: phospholipid, oil, non-ionic surface active agent are first carried out high speed shear by the present invention, three can be merged completely, after adding rhodioside, stirring at low speed, rhodioside can be made to be wrapped in the nanoscale emulsion of phospholipid lipid, solve water miscible problem, enhance rhodioside stability, and the application in external preparation for skin field.
3, for overcoming the complicated preparation technology of above-mentioned rhodioside liposome, rhodioside, by means of high pressure homogenize means, is wrapped in lipid microsphere by the present invention, increases the stability of rhodioside, water solublity and the convenience in cosmetic field application.
4, due to the lipid and cuticular existence of skin, hydrophilic molecule is difficult to be absorbed by body by skin barrier.Rhodioside is wrapped in phospholipid microcapsule nano-emulsion by the present invention, can effectively increase rhodioside fat-soluble, improves rhodioside Transdermal absorption ability, thus enhances the application of rhodioside in external preparation for skin field.
5, high, the particle diameter of the lipid nanoemulsion envelop rate containing rhodioside provided by the invention is less than 150nm, meanwhile, can promote the Transdermal absorption of rhodioside, and be better than prior art; Airtight preservation under the condition of 37 DEG C, rhodioside lipid nanoemulsion provided by the invention still keeps good assimilation effect.
Detailed description of the invention
Following examples for illustration of the present invention, but are not used for limiting the scope of the invention.
Embodiment 1: the nanoscale emulsion of high percutaneous absorbability
1, form:
2, preparation method:
1) respectively phospholipid is dissolved in 70ml chloroform-hexane solution (chloroform: normal hexane, 5:7, v/v), rhodioside is dissolved in 10ml distilled water, after stirring, by two solution mixing, and supersound process, gained Emulsion, through lyophilization process, obtains rhodioside-phosphatide complexes;
2) by rhodioside-phosphatide complexes, caprylic/capric glyceride, polyglycerol monooleate, Tween 80, polyoxyethylene castor oil, the mixing of Polyethylene Glycol caprylic/capric glyceride, high speed shear under 8000rpm condition, without the visible solid content of naked eyes to system;
3) G & W is added step 2) product, high speed shear under 12000rpm condition, obtains colostrum, and colostrum is through high pressure homogenizer process, and pressure 800bar used, circulates 5 times, obtain transparent clear shape nanoscale emulsion.
Embodiment 2: the nanoscale emulsion of high percutaneous absorbability
1, form:
2, preparation method:
1) respectively phospholipid is dissolved in 50ml chloroform-hexane solution (chloroform: normal hexane, 5:7, v/v), rhodioside is dissolved in 10ml distilled water, after stirring, by two solution mixing, and supersound process, gained Emulsion, through lyophilization process, obtains rhodioside-phosphatide complexes;
2) by rhodioside-phosphatide complexes, caprylic/capric glyceride, sorbester p17, polyglycerol monooleate, Tween 80, polyoxyethylene castor oil mixing, high speed shear under 12000rpm condition, without the visible solid content of naked eyes to system;
3) G & W is added step 2) product, high speed shear under 8000rpm condition, obtains colostrum, and colostrum is through high pressure homogenizer process, and pressure 1200bar used, circulates 7 times, obtain transparent clear shape nanoscale emulsion.
Embodiment 3: the nanoscale emulsion of high percutaneous absorbability
1, form:
2, preparation method:
1) respectively phospholipid is dissolved in 50ml chloroform-hexane solution (chloroform: normal hexane, 5:7, v/v), rhodioside is dissolved in 15ml distilled water, after stirring, by two solution mixing, and supersound process, gained Emulsion, through lyophilization process, obtains rhodioside-phosphatide complexes;
2) by rhodioside-phosphatide complexes, caprylic/capric glyceride, sorbester p17, polyglycerol monooleate, Tween 80, the mixing of Polyethylene Glycol caprylic/capric glyceride, high speed shear under 10000rpm condition, without the visible solid content of naked eyes to system;
3) G & W is added step 2) product, high speed shear under 10000rpm condition, obtains colostrum, and colostrum is through high pressure homogenizer process, and pressure 1500bar used, circulates 6 times, obtain transparent clear shape nanoscale emulsion.
Embodiment 4: the nanoscale emulsion of high percutaneous absorbability
1, form:
2, preparation method:
1) respectively phospholipid is dissolved in 40ml chloroform-hexane solution (chloroform: normal hexane, 5:7, v/v), rhodioside is dissolved in 15ml distilled water, after stirring, by two solution mixing, and supersound process, gained Emulsion, through lyophilization process, obtains rhodioside-phosphatide complexes;
2) by rhodioside-phosphatide complexes, caprylic/capric glyceride, sorbester p17, polyglycerol monooleate, Tween 80, the mixing of Polyethylene Glycol caprylic/capric glyceride, high speed shear under 8000rpm condition, without the visible solid content of naked eyes to system;
3) G & W is added step 2) product, high speed shear under 12000rpm condition, obtains colostrum, and colostrum is through high pressure homogenizer process, and pressure 800bar used, circulates 8 times, obtain transparent clear shape nanoscale emulsion.
Embodiment 5: the nanoscale emulsion of high percutaneous absorbability
1, form:
2, preparation method:
1) respectively phospholipid is dissolved in 50ml chloroform-hexane solution (chloroform: normal hexane, 5:7, v/v), rhodioside is dissolved in 15ml distilled water, after stirring, by two solution mixing, and supersound process, gained Emulsion, through lyophilization process, obtains rhodioside-phosphatide complexes;
2) by rhodioside-phosphatide complexes, caprylic/capric glyceride, sorbester p17, polyglycerol monooleate, Tween 80, the mixing of Polyethylene Glycol caprylic/capric glyceride, high speed shear under 10000rpm condition, without the visible solid content of naked eyes to system;
3) G & W is added step 2) product, high speed shear under 10000rpm condition, obtains colostrum, and colostrum is through high pressure homogenizer process, and pressure 2000bar used, circulates 10 times, obtain transparent clear shape nanoscale emulsion.
Comparative example 1:
Choose the embodiment 1 that CN201210434701.7 (CN102871936A) is best, with reference to its composition and preparation method, replace this Radix Rhodiolae extract with rhodioside of the present invention, specific as follows:
1, form:
2, preparation method: [0028] the section content of seeing this patent, repeats no more here.
Experimental example 1: entrapment efficiency determination
1, sample: sample 1-5: the embodiment 1-5 product prepared; Reference substance: product prepared by comparative example 1.
2, experimental technique: adopt dialysis, the nanoscale emulsion getting 1ml rhodioside puts into bag filter, and 40ml deionized water carries out 8h dialysis.Envelop rate (encapsulating efficiency, EE) is calculated as follows:
EE=analyses Determination of Salidroside in rear nanoscale emulsion/rhodioside nanoscale emulsion theoretical content × 100%.
3, result: in table 1.
The different sample envelop rate of table 1
| Title | Sample 1 | Sample 2 | Sample 3 | Sample 4 | Sample 5 | Reference substance |
| Envelop rate | 82.5％ | 85.4％ | 96.1％ | 94.3％ | 93.8％ | 70.1％ |
Table 1 result shows: through the dialysis test of 8h, compared with reference substance, sample 1-5 has fabulous envelop rate, and especially sample 3-5 has extremely significant envelop rate.
Result shows: nanoscale emulsion envelop rate provided by the invention is better than prior art.
Experimental example 2: particle size determination
1, test specimen: sample 1-5: the embodiment 1-5 product prepared; Reference substance: product prepared by comparative example 1.
2, particle size determination:
Adopt Malvern Zetasizer 3000HSA Particle Size Analyzer to detect particle diameter, before mensuration, sample 1-5 and reference substance Millipore ultra-pure water are diluted 30 times
3, result of the test: in table 2.
Table 2: different sample particle diameter size
| Title | Sample 1 | Sample 2 | Sample 3 | Sample 4 | Sample 5 | Reference substance |
| Mean diameter | 141nm | 102nm | 74nm | 81nm | 86nm | 183nm |
Table 2 result shows: the mean diameter after sample 1-5 emulsifying is less than 150nm, and compared with reference substance, sample 1-5 particle diameter obviously reduces, and the particle diameter of sample 3-5 significantly reduces.
Result illustrates: nanoscale emulsion footpath provided by the invention scope meets the requirement of lipid nanoemulsion, and is better than prior art.
Experimental example 3: permeation test in vitro
1, laboratory sample:
Sample 1-5: the embodiment 1-5 product prepared;
Reference substance 1: product prepared by comparative example 1;
The rhodioside aqueous solution of reference substance 2:0.1%.
Before test, by dilution, be 0.1% by rhodioside concentration unification in different sample.
2, test method: get (25 ± 5) g male mice, with the Na of 6%
2s solution sloughs belly wool, and disconnected neck cuts skin of abdomen after putting to death immediately, rejects subcutaneous tissue and fat, repeatedly rinses by purified water.Be fixed on by skin on diffusion cell, upward, by purified water as acceptable solution, rotating speed is 180rpm to horny layer, and diffusion area is 3.3cm
2, acceptance pool cumulative volume is 18ml, 37 DEG C of water-bath circulations.Getting 1 gram of sample is put on Corium Mus, gets acceptable solution 2ml respectively at 1h, 2h, 4h, 6h, 8h, and supplements the blank acceptable solution of same volume, measures each sample content by HPLC method, and unit of account area Percutaneous permeability Q, computing formula is as follows:
Q=Σ CnV/A (wherein Cn represents the sample concentration of the n-th sub-sampling, and V represents the volume of the liquid of acceptance pool, and A represents diffusion area).
After 3rd month, repeat experiment last time again with product of the present invention.
The store method of 3 months is, under being placed in 37 DEG C of conditions, and airtight placement.
3, experimental result:
3.1: different sample unit are Percutaneous permeability: in table 3
Table 3: different sample unit are Percutaneous permeability (μ g/cm
2)
| Title | Sample 1 | Sample 2 | Sample 3 | Sample 4 | Sample 5 | Reference substance 1 | Reference substance 2 |
| Content | 181.8 | 137.4 | 253.9 | 248.1 | 247.5 | 100.5 | 14.6 |
Table 3 result shows: respectively compared with reference substance 1,2, and sample 1-5 can the transdermal amount of increase rhodioside in various degree, and wherein sample 3-5 significantly can increase the transdermal amount of rhodioside.
Different sample unit are Percutaneous permeability after 3.2:3 month: in table 4
Table is different sample unit are Percutaneous permeability (μ g/cm after 4:3 month
2)
| Title | Sample 1 | Sample 2 | Sample 3 | Sample 4 | Sample 5 | Reference substance 1 | Reference substance 2 |
| Content | 91.6 | 89.4 | 188.4. | 169.5 | 173.4 | 43.1 | 3.5 |
Table 3 result shows: respectively compared with reference substance 1,2, sample 3-5 can increase the transdermal amount of rhodioside extremely significantly, wherein sample 3 best results.
Result shows: nanoscale emulsion provided by the invention can promote that rhodioside is absorbed by the skin, and is better than prior art; Airtight preservation 3 months under the condition of 37 DEG C, nanoscale emulsion provided by the invention still keeps good assimilation effect.
Although above with general explanation, detailed description of the invention and test, the present invention is described in detail, and on basis of the present invention, can make some modifications or improvements it, this will be apparent to those skilled in the art.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, all belong to the scope of protection of present invention.
Claims (10)
1. a nanoscale emulsion for high percutaneous absorbability, is characterized in that, it is grouped into by the one-tenth of following weight portion: rhodioside 0.01-5 part, phosphatidase 1-20 parts, oily 5-15 part, non-ionic surface active agent 0.5-20 part and disperse medium 60-90 part.
2. nanoscale emulsion according to claim 1, is characterized in that, described phospholipid is soybean lecithin or Ovum Gallus domesticus Flavus lecithin, preferably soya lecithin.
3. nanoscale emulsion according to claim 1, is characterized in that, described oil is one or both of soybean oil, caprylic/capric glyceride, safflower oil or olive oil, is preferably caprylic/capric glyceride.
4. nanoscale emulsion according to claim 1, is characterized in that, described non-ionic surface active agent is more than four kinds in sorbester p18, sorbester p17, polyglycerol monooleate, Tween 80, polyoxyethylene castor oil or Polyethylene Glycol caprylic/capric glyceride.
5. nanoscale emulsion according to claim 1, is characterized in that, described disperse medium is one or both in water, glycerol or propylene glycol.
6. the nanoscale emulsion according to any one of claim 1-5, it is characterized in that, described nanoscale emulsion is grouped into by the one-tenth of following weight portion: rhodioside 0.1-2 part, phosphatidase 3 .5-10 part, caprylic/capric glyceride 5-15 part, sorbester p17 0-1.5 part, polyglycerol monooleate 0.5-3.5 part, Tween 80 0.5-5 part, polyoxyethylene castor oil 0-5 part, Polyethylene Glycol caprylic/capric 0-5 part, glycerol 40-80 part and water 5-20 part.
7. nanoscale emulsion according to claim 6, it is characterized in that, described nanoscale emulsion is grouped into by the one-tenth of following weight portion: rhodioside 1-2 part, phosphatidase 5-10 parts, caprylic/capric glyceride 10-15 part, sorbester p17 1-1.5 part, polyglycerol monooleate 1.8-2.5 part, Tween 80 2-5 part, Polyethylene Glycol caprylic/capric glyceride 1-3 part, glycerol 58-65 part and water 10-15 part.
8. nanoscale emulsion according to claim 7, it is characterized in that, described nanoscale emulsion is grouped into by the one-tenth of following weight portion: rhodioside 2 parts, phosphatidase 10 part, caprylic/capric glyceride 15 parts, sorbester p17 1.5 parts, polyglycerol monooleate 2.5 parts, Tween 80 5 parts, Polyethylene Glycol caprylic/capric glyceride 1 part, glycerol 58 parts and 15 parts, water.
9. prepare a method for the nanoscale emulsion described in any one of claim 1-8, it is characterized in that, the method comprises the following steps:
1) respectively phospholipid, rhodioside are dissolved in chloroform-hexane solution (chloroform: normal hexane, 5:7, v/v), with in distilled water, after stirring, by two solution mixing, and supersound process, gained Emulsion, through lyophilization process, obtains rhodioside-phosphatide complexes;
2) by step 1) gained rhodioside-phosphatide complexes, oil, non-ionic surface active agent mixing, high speed shear under 8000-12000rpm condition, without the visible solid content of naked eyes to system;
3) disperse medium is added step 2) product, high speed shear under 8000-12000rpm condition, obtains colostrum, and colostrum is through high pressure homogenizer process, and pressure 800-2000bar used, cycle-index 5-10 time, obtains transparent clear shape nanoscale emulsion.
10. the nanoscale emulsion described in any one of claim 1-8 is preparing the application in antioxidative cosmetics.
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| CN106667805A (en) * | 2017-02-03 | 2017-05-17 | 上海应用技术大学 | Sacha inchi oil-containing nanometer essence and preparation method thereof |
| CN109157423A (en) * | 2018-09-30 | 2019-01-08 | 广州启正化工科技有限公司 | A kind of preparation method and application of water-in-oil nano-emulsion |
| CN109394663A (en) * | 2018-11-27 | 2019-03-01 | 爱思开百朗德生物科技（海门）有限公司 | A kind of Chinese torreya oil skin care milk and preparation method thereof |
| CN109662900A (en) * | 2019-02-25 | 2019-04-23 | 南京华狮新材料有限公司 | A kind of phosphatide package nano emulsion composition and its preparation method and application |
| CN113694043A (en) * | 2021-08-17 | 2021-11-26 | 西安电子科技大学 | Salidroside patch for treating muscular atrophy |
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| CN106667805A (en) * | 2017-02-03 | 2017-05-17 | 上海应用技术大学 | Sacha inchi oil-containing nanometer essence and preparation method thereof |
| CN109157423A (en) * | 2018-09-30 | 2019-01-08 | 广州启正化工科技有限公司 | A kind of preparation method and application of water-in-oil nano-emulsion |
| CN109394663A (en) * | 2018-11-27 | 2019-03-01 | 爱思开百朗德生物科技（海门）有限公司 | A kind of Chinese torreya oil skin care milk and preparation method thereof |
| CN109662900A (en) * | 2019-02-25 | 2019-04-23 | 南京华狮新材料有限公司 | A kind of phosphatide package nano emulsion composition and its preparation method and application |
| CN109662900B (en) * | 2019-02-25 | 2022-03-22 | 南京华狮新材料有限公司 | Phospholipid-coated nanoemulsion composition and preparation method and application thereof |
| CN113694043A (en) * | 2021-08-17 | 2021-11-26 | 西安电子科技大学 | Salidroside patch for treating muscular atrophy |
| CN113694043B (en) * | 2021-08-17 | 2023-12-22 | 西安电子科技大学 | Rhodiola rosea glycoside patch for treating muscular atrophy |
| TWI839286B (en) * | 2023-08-08 | 2024-04-11 | 永芙生醫研究有限公司 | Rhodiola rosea nanoemulsion and preparation method thereof |
| CN118845492A (en) * | 2024-07-01 | 2024-10-29 | 王叔和生物医药(武汉)有限公司 | A nanoliposome with high efficiency in scavenging free radicals and its preparation method and application |
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