CN104474009A - Eye cleaning liquid and preparation method thereof - Google Patents
Eye cleaning liquid and preparation method thereof Download PDFInfo
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- CN104474009A CN104474009A CN201410688973.9A CN201410688973A CN104474009A CN 104474009 A CN104474009 A CN 104474009A CN 201410688973 A CN201410688973 A CN 201410688973A CN 104474009 A CN104474009 A CN 104474009A
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Abstract
The invention discloses an eye cleaning liquid for cleaning eyes and a preparation method thereof. Every 1000ml of the eye cleaning liquid is prepared from the following components by weight: 0.2-2g of sodium hyaluronate, 3-9g of sodium chloride, 2-6g of boric acid, 0.2-1g of borax, 1-6g of a felwort extraction liquid, 1-6g of a concha haliotidis extraction liquid, 10-100mg of menthol, 5-50g of borneol, 5g of propylene glycol, 0.3g of methyl p-hydroxybenzoate, 0.15g of propyl p-hydroxybenzoate and purified water which is added to 1000ml. The pH value of the eye cleaning liquid is 6.5-7.5, and the osmotic pressure is 260-330mOsm/kg. The eye cleaning liquid taking Chinese herbal medicines as main raw materials is safe and reliable and has the advantages of being used for preventing and relieving eye fatigue, eye discomfort and eye dryness.
Description
Technical field
The present invention relates to a kind of for eye cleanout fluid cleaning eye and preparation method thereof.
Background technology
Present environmental problem day is aobvious outstanding, and the toxic emission in chemical plant, the exhaust emissions of automobile, haze, sandstorm etc. all can cause or exacerbate ocular discomfort.In addition, extended wear uses contact lens person can cause dry and astringent, the sour swollen fatigue of eyes, has other discomforts such as foreign body sensation, and modern stares at computer cell phone screen for a long time, especially in air-conditioned room, eyes moisture content is more easily lost, and can produce the symptom such as conjunctival congestion, eyestrain.All health that all can affect our eyes above, but existing market also high less than safety, effective, be applicable to the eye external cleanout fluid of public use.Along with the raising of people's living standard, eye problems is day by day in widespread attention, and therefore the production and sales of this series products have the huge market space.
Summary of the invention
Technical problem to be solved by this invention be to provide a kind of adopt Chinese herbal medicine be primary raw material, safe and reliable, for preventing and alleviate the eye cleanout fluid and preparation method thereof of eye strain, ophthalmic uncomfortable, eye dryness.
The present invention's adopted technical scheme that solves the problem is: the every 1000ml of this eye cleanout fluid is prepared from by following composition, hyaluronate sodium 0.2-2g, sodium chloride 3-9g, boric acid 2-6g, Borax 0.2-1g, Radix Gentianae extracting solution 1-6g, Concha Haliotidis extracting solution 1-6g, menthol 10-100mg, Borneolum Syntheticum 5-50mg, propylene glycol 5g, methyl parahydroxybenzoate 0.3g, propyl p-hydroxybenzoate 0.15g, add purified water to 1000ml.
The pH value of eye cleanout fluid of the present invention is 6.5-7.5, and osmotic pressure is 260-330mOsm/kg.
The preparation method of this cleanout fluid is that every 1000ml is made up of following steps:
(1) getting hyaluronate sodium 0.2-2g is dissolved in the 400ml purified water of 70 DEG C-80 DEG C, carefully slowly feeds intake while stirring, for avoiding caking, insulated and stirred more than 0.5 hour, after guaranteeing to dissolve completely, is cooled to less than 30 DEG C;
(2) get sodium chloride 3-9g, boric acid 2-6g, Borax 0.2-1g joins in 500ml water, be stirred to and dissolve completely;
(3) solution of step (1) gained is transferred in step (2) gained solution;
(4) get Radix Gentianae extracting solution 1-6g, Concha Haliotidis extracting solution 1-6g joins in the solution of step (3) gained, be stirred to and dissolve completely;
(5) get Mentholum 10-100mg, Borneolum Syntheticum 5-50mg, grind to form broken after add 2g propylene glycol, completely dissolve after add in the solution of step (4) gained;
(6) get methyl parahydroxybenzoate 0.3g, propyl p-hydroxybenzoate 0.15g joins in 3g propylene glycol, be stirred to after dissolving completely and add in step (5) gained solution, add purified water while stirring to full dose;
(7) adopt the pre-filter cartridge of cleaning-sterilizing to filter step (6) gained solution, obtain eye cleanout fluid.
In the preparation method step (7) of eye cleanout fluid of the present invention, the aperture of pre-filter cartridge is 0.45 micron.
The pH value of preparation method step (7) the gained eye cleanout fluid of eye cleanout fluid of the present invention is 6.5-7.5, and osmotic pressure is 260-330mOsm/kg.
The present invention compared with prior art, has following beneficial effect: 1, this eye cleanout fluid focuses on natural concept, with the addition of Radix Gentianae extracting solution in formula, the natural Chinese medicinal herb extracting solution such as Concha Haliotidis extracting solution, the product made not only environmental protection but also safe and reliable, wherein Radix Gentianae extracting solution take gentianaceae plant as raw material, by the vanguard technology extraction plants herb elite in modern times, without adding antiseptic, its principle active component gentiopicrin, has clearing away liver-fire, except damp and hot effect, record " control the medicine that ophthalmic must be used, go yellow in order and the red swelling of eyeball, stasis of blood meat is raised, unbearably painful " according to Compendium of Material Medica, Concha Haliotidis comes from classical ophthalmology ancient prescription, has another name called natural pearls mother, main containing calcium carbonate and trace element, has suppressing the hyperactive liver and subsiding YANG, effect of liver heat removing and eyesight improving, dizzy for having a headache, cataract, blurring of vision, optic atrohic blindness nyctalopia, records according to " Haiyao Bencao, Oversea Materia Medica " " main optic atrophy, liver lung-wind syndrome heat, hectic fever due to YIN-deficiency labor pole ", records " photophobia again according to Compendium of Material Medica, corneal nebula after pox, deficiency of the liver corneal nebula, optic atrohic blindness, nyctalopia ", therefore Radix Gentianae and Concha Haliotidis effectively can alleviate conjunctival congestion, blurring of vision, the symptoms such as photophobia, 2, the hyaluronate sodium in this eye cleaning fluid composition is gentle low toxicity, has hydrophilic and certain viscoelastic macromolecular compound, effectively can prevent the too fast volatilization of eye moisture, prevent eyes dry and astringent, Borneolum Syntheticum and Mentholum have effect of refreshing and detoxicating, sodium chloride and boric acid, Borax are applicable to the physiological situation physical and chemical parameter of eye, make eye more comfortable, methyl parahydroxybenzoate and propyl p-hydroxybenzoate guarantee the low biological load of product solution, make product safer, 3, the preparation method of this eye cleanout fluid is simple, and output is high, and profit margin is considerable.
Detailed description of the invention
Embodiment 1
The every 1000ml of the present embodiment is prepared from by following composition: hyaluronate sodium 0.2g, sodium chloride 3g, boric acid 2g, Borax 0.2g, Radix Gentianae extracting solution 1g, Concha Haliotidis extracting solution 1g, Mentholum 10mg, Borneolum Syntheticum 5mg, propylene glycol 5g, methyl parahydroxybenzoate 0.3g, propyl p-hydroxybenzoate 0.15g, add purified water to 1000ml.
The every 1000ml of the present embodiment is made up of following steps:
(1) getting hyaluronate sodium 0.2g is dissolved in the 400ml purified water of 70-80 DEG C, carefully slowly feeds intake while stirring, for avoiding caking, insulated and stirred more than 0.5 hour, after guaranteeing to dissolve completely, is cooled to less than 30 DEG C;
(2) get sodium chloride 3g, boric acid 2g, Borax 0.2g joins in 500ml purified water, be stirred to and dissolve completely;
(3) solution of step (1) gained is transferred in step (2) gained solution;
(4) get Radix Gentianae extracting solution 1g, Concha Haliotidis extracting solution 1g joins in the solution of step (3) gained, be stirred to and dissolve completely;
(5) get Mentholum 10mg, Borneolum Syntheticum 5mg, grind to form broken after add 2g propylene glycol, completely dissolve after add in the solution of step (4) gained;
(6) get methyl parahydroxybenzoate 0.3g, propyl p-hydroxybenzoate 0.15g joins in 3g propylene glycol, be stirred to after dissolving completely and add in step (5) gained solution, add purified water while stirring to full dose;
(7) adopt the pre-filter cartridge of cleaning-sterilizing to filter step (6) gained solution, obtain eye cleanout fluid, wherein the aperture of pre-filter cartridge is 0.45 micron, and the pH value of gained eye cleanout fluid is 6.5-7.5, and osmotic pressure is 260-330 mOsm/kg.
Embodiment 2
The every 1000ml of the present embodiment is prepared from by following composition: hyaluronate sodium 0.2g, sodium chloride 5g, boric acid 4g, Borax 0.4g, Radix Gentianae extracting solution 3g, Concha Haliotidis extracting solution 5g, Mentholum 50mg, Borneolum Syntheticum 10mg, propylene glycol 5g, methyl parahydroxybenzoate 0.3g, propyl p-hydroxybenzoate 0.15g, add purified water to 1000ml.
The every 1000ml of the present embodiment is made up of following steps:
(1) getting hyaluronate sodium 0.2g is dissolved in the 400ml purified water of 70 DEG C-80 DEG C, carefully slowly feeds intake while stirring, for avoiding caking, insulated and stirred more than 0.5 hour, after guaranteeing to dissolve completely, is cooled to less than 30 DEG C;
(2) get sodium chloride 5g, boric acid 4g, Borax 0.4g joins in 500ml purified water, be stirred to and dissolve completely;
(3) solution of step (1) gained is transferred in step (2) gained solution;
(4) get Radix Gentianae extracting solution 3g, Concha Haliotidis extracting solution 5g joins in the solution of step (3) gained, be stirred to and dissolve completely;
(5) get Mentholum 50mg, Borneolum Syntheticum 10mg, grind to form broken after add 2g propylene glycol, completely dissolve after add in the solution of step (4) gained;
(6) get methyl parahydroxybenzoate 0.3g, propyl p-hydroxybenzoate 0.15g joins in 3g propylene glycol, be stirred to after dissolving completely and add in step (5) gained solution, add purified water while stirring to full dose;
(7) adopt the pre-filter cartridge of cleaning-sterilizing to filter step (6) gained solution, obtain eye cleanout fluid, wherein the aperture of pre-filter cartridge is 0.45 micron, and the pH value of gained eye cleanout fluid is 6.5-7.5, and osmotic pressure is 260-330 mOsm/kg.
Embodiment 3
The every 1000ml of the present embodiment is prepared from by following composition: hyaluronate sodium 2g, sodium chloride 9g, boric acid g, Borax 1g, Radix Gentianae extracting solution 6g, Concha Haliotidis extracting solution 20g, Mentholum 10mg, Borneolum Syntheticum 50mg, propylene glycol 5g, methyl parahydroxybenzoate 0.3g, propyl p-hydroxybenzoate 0.15g, add purified water to 1000ml.
The every 1000ml of the present embodiment is made up of following steps:
(1) getting hyaluronate sodium 2g is dissolved in the 400ml purified water of 70 DEG C-80 DEG C, carefully slowly feeds intake while stirring, for avoiding caking, insulated and stirred more than 0.5 hour, after guaranteeing to dissolve completely, is cooled to less than 30 DEG C;
(2) get sodium chloride 9g, boric acid 6g, Borax 1g joins in 500ml purified water, be stirred to and dissolve completely;
(3) solution of step (1) gained is transferred in step (2) gained solution;
(4) get Radix Gentianae extracting solution 6g, Concha Haliotidis extracting solution 20g joins in the solution of step (3) gained, be stirred to and dissolve completely;
(5) get Mentholum 10mg, Borneolum Syntheticum 50mg, grind to form broken after add 2g propylene glycol, completely dissolve after add in the solution of step (4) gained;
(6) get methyl parahydroxybenzoate 0.3g, propyl p-hydroxybenzoate 0.15g joins in 3g propylene glycol, be stirred to after dissolving completely and add in step (5) gained solution, add purified water while stirring to full dose;
(7) adopt the pre-filter cartridge of cleaning-sterilizing to filter step (6) gained solution, obtain eye cleanout fluid, wherein the aperture of pre-filter cartridge is 0.45 micron, and the pH value of gained eye cleanout fluid is 6.5-7.5, and osmotic pressure is 260-330 mOsm/kg.
The occupation mode of this eye cleanout fluid is: contacted with human body eye table by eye cleanout fluid by cleaning cup, and then within a short period of time is brought into internal metabolism excretion by nasal tube, tear stains.
Claims (5)
1. an eye cleanout fluid, it is characterized in that: every 1000ml is prepared from by following composition, hyaluronate sodium 0.2-2g, sodium chloride 3-9g, boric acid 2-6g, Borax 0.2-1g, Radix Gentianae extracting solution 1-6g, Concha Haliotidis extracting solution 1-6g, menthol 10-100mg, Borneolum Syntheticum 5-50mg, propylene glycol 5g, methyl parahydroxybenzoate 0.3g, propyl p-hydroxybenzoate 0.15g, add purified water to 1000ml.
2. eye cleanout fluid according to claim 1, is characterized in that: the pH value of described eye cleanout fluid is 6.5-7.5, and osmotic pressure is 260-330mOsm/kg.
3. the preparation method of a kind of eye cleanout fluid according to claim 1, is characterized in that: every 1000ml is made up of following steps,
(1) getting hyaluronate sodium 0.2-2g is dissolved in the 400ml purified water of 70-80 DEG C, carefully slowly feeds intake while stirring, for avoiding caking, insulated and stirred more than 0.5 hour, after guaranteeing to dissolve completely, is cooled to less than 30 DEG C;
(2) get sodium chloride 3-9g, boric acid 2-6g, Borax 0.2-1g joins in 500ml water, be stirred to and dissolve completely;
(3) solution of step (1) gained is transferred in step (2) gained solution;
(4) get Radix Gentianae extracting solution 1-6g, Concha Haliotidis extracting solution 1-6g joins in the solution of step (3) gained, be stirred to and dissolve completely;
(5) get Mentholum 10-100mg, Borneolum Syntheticum 5-50mg, grind to form broken after add 2g propylene glycol, completely dissolve after add in the solution of step (4) gained;
(6) get methyl parahydroxybenzoate 0.3g, propyl p-hydroxybenzoate 0.15g joins in 3g propylene glycol, be stirred to after dissolving completely and add in step (5) gained solution, add purified water while stirring to full dose;
(7) adopt the pre-filter cartridge of cleaning-sterilizing to filter step (6) gained solution, obtain eye cleanout fluid.
4. the preparation method of a kind of eye cleanout fluid according to claim 3, is characterized in that: described in step (7), the aperture of pre-filter cartridge is 0.45 micron.
5. the preparation method of a kind of eye cleanout fluid according to claim 3, is characterized in that: the pH value of step (7) gained eye cleanout fluid is 6.5-7.5, and osmotic pressure is 260-330mOsm/kg.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410688973.9A CN104474009A (en) | 2014-11-26 | 2014-11-26 | Eye cleaning liquid and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410688973.9A CN104474009A (en) | 2014-11-26 | 2014-11-26 | Eye cleaning liquid and preparation method thereof |
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| CN104474009A true CN104474009A (en) | 2015-04-01 |
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| CN201410688973.9A Pending CN104474009A (en) | 2014-11-26 | 2014-11-26 | Eye cleaning liquid and preparation method thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106974876A (en) * | 2017-03-14 | 2017-07-25 | 天津喜诺生物医药有限公司 | A kind of method that eye care solution is prepared by horseshoe crab cell pyrolysis liquid |
| CN107050086A (en) * | 2017-02-07 | 2017-08-18 | 商丘市第人民医院 | A kind of ophthalmology cleaning agent and preparation method thereof |
| CN107440975A (en) * | 2017-09-18 | 2017-12-08 | 江苏天眼医药科技股份有限公司 | A kind of composition for eye-care |
| CN109908198A (en) * | 2019-04-24 | 2019-06-21 | 嘉兴力山明朗生物医药科技有限公司 | A kind of corn flower collyrium |
| WO2023013628A1 (en) * | 2021-08-03 | 2023-02-09 | 小林製薬株式会社 | Eyewash composition |
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| CN1083360A (en) * | 1993-06-17 | 1994-03-09 | 凌沛学 | Runshu eye drops and preparation method thereof |
| CN1327839A (en) * | 2001-04-15 | 2001-12-26 | 邓幼明 | Eye-protecting eyedrops |
| CN102362924A (en) * | 2011-10-23 | 2012-02-29 | 长春中医药大学 | Medicinal composition for treating ophthalmic diseases and preparation method thereof |
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2014
- 2014-11-26 CN CN201410688973.9A patent/CN104474009A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1083360A (en) * | 1993-06-17 | 1994-03-09 | 凌沛学 | Runshu eye drops and preparation method thereof |
| CN1327839A (en) * | 2001-04-15 | 2001-12-26 | 邓幼明 | Eye-protecting eyedrops |
| CN102362924A (en) * | 2011-10-23 | 2012-02-29 | 长春中医药大学 | Medicinal composition for treating ophthalmic diseases and preparation method thereof |
Non-Patent Citations (1)
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| 徐元贞 等: "《中华方药宝典》", 31 March 2012 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107050086A (en) * | 2017-02-07 | 2017-08-18 | 商丘市第人民医院 | A kind of ophthalmology cleaning agent and preparation method thereof |
| CN106974876A (en) * | 2017-03-14 | 2017-07-25 | 天津喜诺生物医药有限公司 | A kind of method that eye care solution is prepared by horseshoe crab cell pyrolysis liquid |
| CN107440975A (en) * | 2017-09-18 | 2017-12-08 | 江苏天眼医药科技股份有限公司 | A kind of composition for eye-care |
| CN109908198A (en) * | 2019-04-24 | 2019-06-21 | 嘉兴力山明朗生物医药科技有限公司 | A kind of corn flower collyrium |
| WO2023013628A1 (en) * | 2021-08-03 | 2023-02-09 | 小林製薬株式会社 | Eyewash composition |
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