CN104352230A - Non-invasive thrombosis detector - Google Patents
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Abstract
The invention provides a non-invasive thrombosis detector. The non-invasive thrombosis detector comprises a main control module; the main control module is connected with a light source driver module; the light source driver module is connected with two probes respectively through different channels; detection signals of the probes are transmitted back to the main control module through a data processing module; the main control module receives data of a data transmission and processing module, converts the data into hemodynamic parameters, and exchanges data with an imaging module; a power supply system supplies power to the whole device. The hemodynamic parameters are acquired through a near infrared examination technique, data is analyzed, thrombosis changing images are dynamically displayed through an imaging algorithm and are compared with symmetrical tissue detection images and a human body tissue classified imaging database, a thrombosis part is detected, the thromboembolism degree is evaluated, a thromboembolism patient is monitored in real time, and the treatment effect on the thromboembolism patient is evaluated.
Description
Technical field
The present invention relates to medical instruments field, particularly a kind of non-intrusion type thrombometer.
Background technology
Thrombosis is owing to forming clot artery-clogging in blood, blood circulation is obstructed and causes, thrombosis is died from every year more than 1,500 ten thousand people in the whole world according to statistics, become total death toll first disease in the whole world, Guangzhou Daily 2011 one section report China's thrombotic disease present high morbidity, high dead, height is disabled, this " four is high " feature of high recurrence, subject population reaches more than 10,000,000.Now conventional thrombus treatment means are vascular surgery and Drug therapy, all need suitable technological means to guard and assess curative effect.Wherein vascular surgery efficiency comparison is high, usually needs certain technological means again to check thrombus area, evaluate surgical effect after operation completes.On the other hand, Drug therapy is a comparatively very long process, and these medicines have the potential danger producing other large artery trunks or visceral hemorrhage mostly, therefore the special instrument needing a kind of portable monitoring thrombosis being even applicable to domestic to change, monitor patients physiological situation changes, and evaluates medication effect.Further, those are at the clinical patient of hospitalize, and normally the thrombosis state of an illness is relatively more serious, and thrombosis causes the physiological reaction of people relatively more violent, is sometimes also in peril of one's life.Therefore it is extremely important that the instrument that the monitoring thrombosis that a kind of energy is real-time changes shows.
In hospital; there is no special thrombometer at present; usually following equipment can be selected: digital subtraction angiography (DSA) to the detection of thrombosis; Magnetic Resonance Angiography (MRA); CT blood vessel imaging (CTA); through cranium color doppler ultrasonography (TCCS), Optical Coherence Tomography Imaging Technology (OCT).Wherein TCCS resolution is not high, and OCT imaging depth is shallow, is not conventional detection means; And DSA, CTA, all have injury to human body, assess therapeutic effect large to injury of human with it, be not suitable for repeatedly using in a short time, MRA costly, and has larger limitation in the thrombosis that display is less.And the said equipment is not all portable detection equipment, all needs large scale system to support, and monitor continuously when being unsuitable for long, be not suitable for local thrombus and detect the monitoring with thrombus disease.Therefore, present patent application invention a kind ofly to detect based on non-intrusion type, completely noninvasive, real-time continuous, can continuous detecting more than 48 hours, portable can the optics blood vessels thromboembolism monitor of domestic.
Through consulting, the instrument that thrombosis detects has number of patent application to be 92215325 " Portable thrombometer " utility model, the patent No. is ZL200520021524.5 " automatic rotary thrombus detection instrument " utility model, and the patent No. is ZL200720199013.1 " external stealthy thrombosis detects intelligent analytical instrument " utility model." Portable thrombometer " its principle is that the coagulation by extracting blood of human body analysed for plasma realizes, and namely its method is unfavorable for practical operation, and belongs to again the mode having wound, is not suitable for doing monitoring and uses; " automatic rotary thrombus detection instrument ", " external stealthy thrombosis detects intelligent analytical instrument " are by extracting blood, then some parameter of vim and vigour are detected, be not suitable for repeatedly using same people, and the thrombosis monitoring of hospital is usually (be mainly blood pressure by human body physiologic parameters, pulse, the rhythm of the heart etc.) carry out the change of indirect reaction thrombosis, the development of thrombosis can not be reflected in real time.A kind of direct noninvasive thrombosis is not also had to detect and monitor now.Therefore, provide a kind of noninvasive novel thrombus checkout gear, well solve the deficiency of foregoing invention, the situation of change of long-time Dynamic Announce thrombosis just seems particularly necessary.
Summary of the invention
For solving above-mentioned prior art Problems existing, the object of the present invention is to provide a kind of non-intrusion type thrombometer.Be applicable to nearly all local thrombus detect, be particularly suitable for outdoor activity and train the thromboembolism caused to detect, be suitable for thrombus treatment recruitment evaluation and thrombosis patient care, the present invention has stable performance, device is simple, portable and be suitable for the wide feature in position.
For achieving the above object, technical scheme of the present invention is:
A kind of non-intrusion type thrombometer comprises, main control module, main control module connects light source driver module, light source driver module connects two probes through channel selecting respectively by different passages, probe detection signal transmits back main control module through data processing module, described main control module and image-forming module and data are transmitted and are completed exchanges data with processing module, and power-supply system is that whole device is powered;
Main control module is the control core of whole system, comprises and controls the work of light source driving chip, carries out periodic sampling, process data, control data transmission and storage, be controlled to picture module work according to setting sequential; Wherein, voltage signal is converted into optical density change by date processing, be converted into hemodynamic parameter change via spatial discrimination near infrared spectroscopy or correction Beer-Lambert law, such as blood oxygen, blood appearance, blood flow, storage data is hemodynamic data; Imaging is calculated as and is similar to based on diffuse optical or inverse problem that Monte Carlo obtains optical transport is resolved and obtained each hemodynamic parameter at the image detecting site distribution;
Probe is made up of with the light-sensitive detector series that can detect the optical attenuation change that thrombi tissue light transmission to be measured is returned the near-infrared light sources that two pieces at least can be launched two kinds of different near infrared lights;
Light source driver module, for driving light source, can make multi wave length illuminating source successively light as requested and extinguish;
Data reason module, by the signal detected, through amplification filtering, analog digital conversion, passes to main control module, and the primary signal of collection is the voltage signal characterizing light intensity attenuation;
Data transmission and memory module, select transmission mode to transmit data as required, comprise wired interfacing, as USB, DB9 interface; Wireless bluetooth, WIFI, radio communication mode; And data are stored in memorizer, memorizer is divided into two parts, is divided into mainframe memory and extended menory, and extended menory is u dish, SD card, or other storage mediums;
Imaging system, forms by with DSP main control chip or independent dsp chip and display screen, by master control module controls by imaging algorithm to the imaging of data reprocessing.
Further, described image-forming module is processed by computer, the data gathered, by data transmission blocks, is transferred on computer, writes computer end software, adopt the algorithm identical with image-forming module, carry out imaging.
Further, described probe comprises a near infrared light light source launching at least two kinds of wavelength and more than 4 and 4 light-sensitive detectors be arranged on around described light source, and the distance between described light source center and described light-sensitive detector center is 15mm ~ 45mm; The all wavelengths that light source comprises, in 600-980nm scope, typical wavelength combinations at least comprises a wavelength at 700-800nm, a wavelength is at 800-900nm, each wavelength light that light source comprises can be lighted according to set sequential by drived control respectively or extinguish, the minimum response degree of light-sensitive detector will meet the optical power signals that can detect under light source low-power, such as OPT101.
Further, the distance between described light source center and described light-sensitive detector center is for the adult of common yellow skin or pale skin, and representative value is 20mm ~ 30mm, and for infant, representative value is 15mm ~ 25mm.
Further, popping one's head in is made by flexible material, to slow down thromboembolism position build-up of pressure, strengthens comfort, and optic probe also has subsidiary ties up bellyband, the soft material of absorption skin or medical adhesive material.
Further, described power-supply system is cable power or radio source.
Relative to prior art, beneficial effect of the present invention is: the present invention utilizes near infrared light Examined effect to obtain hemodynamic parameter, analytical data, utilize imaging algorithm, Dynamic Announce thrombosis modified-image, be categorized into symmetrical tissue detection image and tissue and compare as data base, thrombi is detected and makes thromboembolism scale evaluation, and in real time thromboembolism patient is guarded and assessment is made to the therapeutic effect of thrombosis patient.
Accompanying drawing explanation
Fig. 1. for apparatus of the present invention carry image-forming module system block diagram.
Fig. 2. for the present invention is by the system block diagram of Computer-generated images.
Fig. 3. the probe plate schematic layout pattern of a light source four light sensor squares arrangement.
Fig. 4. the probe plate schematic layout pattern of a light source six light sensor circular arrangement.
Fig. 5. the probe plate schematic layout pattern of a light source eight light sensor regular octahedron arrangements.
Fig. 6. the probe plate schematic layout pattern of two each and every one light sources, eight light sensor squares arrangement.
Detailed description of the invention
Below in conjunction with the drawings and the specific embodiments, the present invention program is described in further detail,
As shown in Figure 1, a kind of non-intrusion type thrombometer, comprise, main control module, main control module connects light source driver module, and light source driver module connects two probes through channel selecting respectively by different passages, and probe detection signal transmits back main control module through data processing module, described main control module and image-forming module and data are transmitted and are completed exchanges data with processing module, and electric power system is that whole device is powered;
Main control module is the control core of whole system, comprises and controls the work of light source driving chip, carries out periodic sampling, process data, control data transmission and storage, be controlled to picture module work according to setting sequential; Wherein, voltage signal is converted into optical density change by date processing, is being converted into hemodynamic parameter change, such as blood oxygen, blood appearance, blood flow etc. via spatial discrimination near infrared spectroscopy or correction Beer-Lambert law.Storage data is hemodynamic data; Imaging is calculated as and is similar to based on diffuse optical or inverse problem that Monte Carlo obtains optical transport is resolved and obtained each hemodynamic parameter at the image detecting site distribution;
Probe is made up of with the light-sensitive detector series that can detect the optical attenuation change that thrombi tissue light transmission to be measured is returned the near-infrared light sources that two pieces at least can be launched two kinds of different near infrared lights.
Light source driver module, for driving light source, can make multi wave length illuminating source successively light as requested and extinguish;
Data reason module, by the signal detected, through amplification filtering, analog digital conversion, passes to main control module.The primary signal gathered is the voltage signal characterizing light intensity attenuation;
Data transmission and memory module, select transmission mode to transmit data as required, comprise wired interfacing, as interfaces such as USB, DB9; Wireless bluetooth, WIFI, the communication modes such as radio frequency; And data are stored in memorizer, memorizer is divided into two parts, is divided into mainframe memory and extended menory, and extended menory can be the storage mediums such as u dish, SD card;
Imaging system, forms by with DSP main control chip or independent dsp chip and display screen, by master control module controls by imaging algorithm to the imaging of data reprocessing.
Further, described image-forming module can also transfer to computer to process, and the data gathered, by data transmission blocks, is transferred on computer, writes computer end software, adopt the algorithm identical with image-forming module, carry out imaging.
Further, described optic probe comprises a near infrared light light source can launching at least two kinds of wavelength and more than 4 and 4 light-sensitive detectors be arranged on around described light source, and the distance between described light source center and described light-sensitive detector center is 15mm ~ 45mm; The all wavelengths that light source comprises, in 600-980nm scope, typical wavelength combinations at least comprises a wavelength at 700-800nm, a wavelength is at 800-900nm, each wavelength light that light source comprises can be lighted according to set sequential by drived control respectively or extinguish, the minimum response degree of light-sensitive detector will meet the optical power signals that can detect under light source low-power, such as OPT101.
Further, the distance between described light source center and described light-sensitive detector center is for the adult of common yellow skin or pale skin, and representative value is 20mm ~ 30mm, and for infant, representative value is 15mm ~ 25mm.
Further, optic probe is made by flexible material, to slow down thromboembolism position build-up of pressure, strengthens comfort, and optic probe also has subsidiary ties up bellyband, the soft material of absorption skin or medical adhesive material.
Further, power-supply system, point two sets of plan, one powers for cable power, use during clinical long-time monitoring; One is portable power source pattern, uses when can be used for outdoor activity or training, electricity stored by portable power source is minimum can make whole system work two hours and more than.
Native system is made up of seven modules, its working method is: master control module controls light source drives, light the light source on probe on demand, on probe, light-sensitive detector receives the optical attenuation variable signal that optical transport is returned, gating passage then Signal transmissions to data processing module, by the amplification in data processing module, filtering, analog to digital conversion circuit, convert the digital signal of needs to, for main control module calls, main control module converts hemodynamic parameter to voltage signal, and control image-forming module and the work of data transmission memory module, complete the transmission storage of data as required, image-forming module is by certain algorithm, data of coming are passed to main control module and carries out reprocessing arrangement, display is transferred to carry out imaging display, call simultaneously this device of human normal tissue adopt the relevant information of clinical database, imaging is as comparison chart picture in the display, the thromboembolism station diagram picture of collection and antimere image or database images is observed to compare, observe its convergent situation, draw the lesion degree of thrombosis.
Operation principle of the present invention is: master control module controls light source drives, light the light source on probe on demand, on probe, light-sensitive detector receives the optical attenuation variable signal that optical transport is returned, gating passage then Signal transmissions to data processing module, by the amplification in data processing module, filtering, analog to digital conversion circuit, convert the digital signal of needs to, for main control module calls, main control module converts hemodynamic parameter to voltage signal, and controls image-forming module and the work of data transmission memory module, completes the transmission storage of data as required.Because the present invention at least comprises two optic probes.When the antimere at patient's blood vessels thromboembolism position is normal, one of them probe optionally can be placed in the normal portions of this symmetry, to obtain the normal portions data of contrast.Another kind of mode declines normal control position, all for needing one or more positions of monitoring, detection data and this device of human normal tissue is adopted clinical database comparison, to obtain blood vessels thromboembolism situation information.
Human normal tissue clinical database that this device is adopted, this data base consists of the data of some position of normal person being carried out to imaging and obtaining this device.This data base can be called by image-forming module, selects to show, as a reference standard with thrombosis same area.
Appraisal procedure: thrombosis assessment is by thromboembolism image areas figure and antimere image, and the width in database diagram or two amplitude ratios pair, observe its convergent effect reach a conclusion.
By such scheme, we devise a set of experimental provision, and wherein light source adopts the three wave length LED of EPITEX company; Light source drives and uses Texas Instrument TLC series multichannel light source drive chip; The STM32F407 series microprocessor that the process core that main control module, image-forming module, data processing module use is STMicw Electronics; Data transmission and store sample serial ports turn USB and TF card; Power-supply system can provide 3.3V, 5V voltage of current stabilization.
As shown in Figure 2, it adopts Computer-generated images, working method is: master control module controls light source drives, light the light source on probe on demand, on probe, light-sensitive detector receives the optical attenuation variable signal that optical transport is returned, then Signal transmissions to data processing module, by the amplification in data processing module, filtering, analog to digital conversion circuit, convert the digital signal of needs to, for main control module calls, the work of master control module controls data transmission stocking system, the transmission completing data as required stores, data import computer end into, wherein the transmission means of data can be wired USB etc. or wireless bluetooth etc., computer carries out imaging to data according to a certain method the data received, call simultaneously this device of human normal tissue adopt the relevant information of clinical database, as comparison chart picture, the thromboembolism station diagram picture of collection and antimere image or database images is observed to compare, observe its convergent situation, draw the lesion degree of thrombosis.
Fig. 3 to Fig. 5 gives light source and the feasible arrangement mode of light-sensitive detector, but is not limited only to this, as long as the central point distance met between light source and light-sensitive detector is between 15mm ~ 45mm.
As shown in Figure 3, provide the probe shape of a light-sensitive detector quadrate arrangement, the value of d1 should between 15mm ~ 45mm.
As shown in Figure 4, a light source six light sensor circular arrangement, the value of d1 should between 15mm ~ 45mm.
As shown in Figure 5, eight the light sensor octagon arrangements of a light source, the value of d1 should between 15mm ~ 45mm.
As shown in Figure 6,8 the light sensor rectangle shape arrangements of two light sources, the value of d1 and d2 should between 15mm ~ 45mm.
The above, be only the specific embodiment of the present invention, but protection scope of the present invention is not limited thereto, and any change of expecting without creative work or replacement, all should be encompassed within protection scope of the present invention.Therefore, the protection domain that protection scope of the present invention should limit with claims is as the criterion.
Claims (6)
1. a non-intrusion type thrombometer, it is characterized in that, comprise, main control module, main control module connects light source driver module, and light source driver module connects two probes through channel selecting respectively by different passages, and probe detection signal transmits back main control module through data processing module, described main control module and image-forming module and data are transmitted and are completed exchanges data with processing module, and power-supply system is that whole device is powered;
Main control module is the control core of whole system, comprises and controls the work of light source driving chip, carries out periodic sampling, process data, control data transmission and storage, be controlled to picture module work according to setting sequential; Wherein, voltage signal is converted into optical density change by date processing, be converted into hemodynamic parameter change via spatial discrimination near infrared spectroscopy or correction Beer-Lambert law, such as blood oxygen, blood appearance, blood flow, storage data is hemodynamic data; Imaging is calculated as and is similar to based on diffuse optical or inverse problem that Monte Carlo obtains optical transport is resolved and obtained each hemodynamic parameter at the image detecting site distribution;
Probe is made up of with the light-sensitive detector series that can detect the optical attenuation change that thrombi tissue light transmission to be measured is returned the near-infrared light sources that two pieces at least can be launched two kinds of different near infrared lights;
Light source driver module, for driving light source, can make multi wave length illuminating source successively light as requested and extinguish;
Data reason module, by the signal detected, through amplification filtering, analog digital conversion, passes to main control module, and the primary signal of collection is the voltage signal characterizing light intensity attenuation;
Data transmission and memory module, select transmission mode to transmit data as required, comprise wired interfacing, as USB, DB9 interface; Wireless bluetooth, WIFI, radio communication mode; And data are stored in memorizer, memorizer is divided into two parts, is divided into mainframe memory and extended menory, and extended menory is u dish, SD card, or other storage mediums;
Imaging system, forms by with DSP main control chip or independent dsp chip and display screen, by master control module controls by imaging algorithm to the imaging of data reprocessing.
2. non-intrusion type thrombometer according to claim 1, is characterized in that, described image-forming module is processed by computer, the data gathered, by data transmission blocks, be transferred on computer, write computer end software, adopt the algorithm identical with image-forming module, carry out imaging.
3. non-intrusion type thrombometer according to claim 1, it is characterized in that, described probe comprises a near infrared light light source launching at least two kinds of wavelength and more than 4 and 4 light-sensitive detectors be arranged on around described light source, and the distance between described light source center and described light-sensitive detector center is 15mm ~ 45mm; The all wavelengths that light source comprises, in 600-980nm scope, typical wavelength combinations at least comprises a wavelength at 700-800nm, a wavelength is at 800-900nm, each wavelength light that light source comprises can be lighted according to set sequential by drived control respectively or extinguish, the minimum response degree of light-sensitive detector will meet the optical power signals that can detect under light source low-power, such as OPT101.
4. non-intrusion type thrombometer according to claim 3, it is characterized in that, the distance between described light source center and described light-sensitive detector center is for the adult of common yellow skin or pale skin, and representative value is 20mm ~ 30mm, for infant, representative value is 15mm ~ 25mm.
5. non-intrusion type thrombometer according to claim 1, it is characterized in that, popping one's head in is made by flexible material, to slow down thromboembolism position build-up of pressure, strengthen comfort, optic probe also has subsidiary ties up bellyband, the soft material of absorption skin or medical adhesive material.
6. the non-intrusion type thrombometer according to above-mentioned arbitrary claim, is characterized in that, power-supply system is cable power or radio source.
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