CN104306495B

CN104306495B - A kind of Chinese medicine for external application of cure scapulohumeral periarthritis and preparation method thereof

Info

Publication number: CN104306495B
Application number: CN201410598121.0A
Authority: CN
Inventors: 不公告发明人
Original assignee: Individual
Current assignee: Guangzhou Yu Yu Cosmetics Technology Co ltd
Priority date: 2014-10-30
Filing date: 2014-10-30
Publication date: 2016-09-28
Anticipated expiration: 2034-10-30
Also published as: CN104306495A

Abstract

The invention provides the Chinese medicine for external application of a kind of cure scapulohumeral periarthritis, described various crude drug is: Herba Epimedii 10～20 parts, the Cortex Eucommiae 10～20 parts, Radix Morindae Officinalis 10～20 parts, Fructus Psoraleae 10～20 parts, the Radix Linderae 10～20 parts, Radix Salviae Miltiorrhizae 10～20 parts, Rhizoma Corydalis 10～20 parts, geranium 10～20 parts, Caulis Spatholobi 10～20 parts, the Radix Angelicae Dahuricae 10～20 parts, Herba Asari 10～20 parts, Olibanum (processed) 10～20 parts, Myrrha 10～20 parts, Radix Clematidis 10～20 parts, Radix Dipsaci 10～20 parts, Cortex Acanthopancis 10～20 parts, Herba Sarcandrae 10～20 parts, Caulis Trachelospermi 10～20 parts, Pheretima 10～20 parts, Eupolyphaga Seu Steleophaga 10～20 parts, Rhizoma Drynariae 10～20 parts, Herba speranskiae tuberculatae 10～20 parts.The present invention improves blood circulation, make to fill blood, the volatile ingredient of the medicine of cold-dispelling, promoting blood circulation to remove obstruction in the collateral, relaxing muscles and tendons through skin absorption, there is dredging space between skin and muscles, the effect of blood circulation promoting and blood stasis dispelling；Make effective ingredient directly penetrate into the deep tissue of diseased region simultaneously, utilize heating power to absorb arrival focus through transdermally people and give full play to drug effect, play pain relieving, detumescence, spasmolytic, minimizing adhesion and promote the effect of healing, thus reaching to treat the purpose of disease.

Description

A kind of Chinese medicine for external application of cure scapulohumeral periarthritis and preparation method thereof

Technical field

The present invention relates to, containing the health product deriving from plant composition, treat shoulder particularly to one Scorching Chinese medicine for external application and preparation method thereof.

Background technology

Scapulohumeral periarthritis motherland medical science referred to as " scapulohumeral periarthritis ", " congealed shoulder ", " bursitis of shoulder " etc., be with shoulder joint Pain is main, first aches in paroxysmal, followed by moves a kind of commonly encountered diseases of obstacle, frequently-occurring disease.Suffer from Having the patient of scapulohumeral periarthritis, conscious have cold air to enter shoulder, also has patient to feel there is cold air inside shoulder joint Outwards emerge, therefore also known as " scapulohumeral periarthritis ".Its lesion characteristic is extensive, and i.e. pain is extensive, function limitation is wide The extensive scapulohumeral periarthritis of general, tenderness is moving back of a kind of capsula articularis humeri and surrounding ligaments, tendon and synovial bursa Row becomes and chronic nonspecific inflammation.Be also called " congealed shoulder ", " leak out shoulder ", " scapulohumeral periarthritis ", " stiff shoulder ", " bursitis of shoulder " etc., be called for short " scapulohumeral periarthritis ".It is with shoulder arthralgia, limitation of activity Chronic disease for principal character.

Traditional medicine is considered asthenia with age, deficiency of both the liver and kidney, insufficiency of vital energy and blood, the most flourish muscle of blood, and " seven Eight, irritability declines, the tendon being unable to move " (" Plain Questions innocence in ancient times opinion "), muscles loses in moistening foster, phlegm-turbidity and blood stasis Resistance passages through which vital energy circulates and joint, therefore joint is lost in sliding profit.If being attacked shoulder by wound or wind-cold damp pathogen, cause cold coagulation Fascia, blockage of meridian, muscles contracture, caused by passages through which vital energy circulates contracture.

In addition to having individually clear and definite trauma history person's onset relatively anxious, the many onsets of primary disease are slow, and Chang Yin upper act abduction is moved Making to cause pain to begin to be noted, cardinal symptom is shoulder pain, and shoulder mobility is limited or stiff.Pain Can be dull pain, lancinating pain, ask night and increase the weight of, uncomfortable pain after even bitterly waking up or waking up, ambulation be for a moment Can fall asleep once again.

Shoulder joint each side limitation of activity, with abduction, outward turning, after to stretch obstacle the most obvious, as can not combing Hair, wear the clothes.Shoulder soft tissue asks generation extensive adhesion, and makes all activities the most limited.Sick Journey elder, it is seen that pectoral girdle amyotrophy, especially obvious with triangular muscle atrophy.X ray examination: belong to negative more, Meaningless to directly diagnosis, but B&J disease can be got rid of.The most visible osteoporosis, supraspinatus The shade of increase in density is had at tendon calcification, or greater tubercle.

According to pathogenesis, primary disease is divided into pain phase, scapulohumeral periarthritis phase, catabasis.The pain phase is the onset initial stage, About 1～3 months.The main clinical manifestation of this phase patient is pain.Its joint motion is limited, be due to The muscle spasm that pain causes, caused by ligament, joint capsule contracture, therefore shoulder joint itself still can have suitable model The mobility enclosed.Scapulohumeral periarthritis phase in this period, patient pain's symptom the most substantially alleviated, and clinical manifestation is that shoulder joint is lived Dynamic critical constraints, even loses.Shoulder joint is because of the extensive adhesion of shoulder soft tissue, and range of activity is little, outside doing When exhibition and flexion, there is, therewith swinging, phenomenon of shrugging in scapula.Catabasis is the convalescent period of this disease Or healing process.Current period symptom with pain cut down, treatment and daily life work in shoulder joint contracture, Adhesion gradually eliminates and recovers normal function.

Using kidney tonifying, essence replenishing, blood circulation promoting and blood stasis dispelling in clinic, the treatment way cure scapulohumeral periarthritis of removing obstruction in the collateral to relieve pain is received Arrive preferable clinical efficacy.And western medicine is thought more, scapulohumeral periarthritis is inflammation, antiinflammatory, at present Patient can only use analgesic, pain killer injection, anesthesia needle, naturopathy etc. to carry out relief of symptoms.Select in time, Regular, effective, not have the Therapeutic Method of side effect be crucial.Therefore select external application Chinese medicine in the majority, treatment effect Fruit can be easy to use very well, and not allergy is free from side effects, it then follows traditional Chinese medical science general rule principle the most bitterly, is controlled Treating scapulohumeral periarthritis, external used medicine is because having higher denseness, so it possesses active constituent content height, analysis Go out the series of advantages such as speed is slow, effect is long-term persistently, local efficacy is practical, act on more significantly. The Chinese medicine for outer use of cure scapulohumeral periarthritis of the present invention, its effective ingredient can penetrate skin and produce promoting blood circulation and stopping pain Silt, the network that stimulates the menstrual flow away, the effects such as deep, expelling wind and cold of having one's ideas straightened out, the most comprehensive for pathogenic characteristic And play curative effect, improve perilesional histotrophic nutrition, play the effect repairing osteopathia tissue, be finally reached Cure purpose.

Summary of the invention

The technical problem to be solved is, modern Western medicine thinks that scapulohumeral periarthritis is inflammation, antiinflammatory , current patient can only use analgesic, pain killer injection, anesthesia needle, naturopathy etc. to carry out relief of symptoms. And Chinese medicine is because using inconvenience, the smell is awful, and modern quick to rhythm of life does not accept. Following traditional Chinese medical science general rule principle the most bitterly, fundamentally cure scapulohumeral periarthritis, Internal TCM acts on effect jointly Fruit is notable.Oral medicinal herb blood circulation promoting and blood stasis dispelling, expelling wind and cold, enriching kidney essence, externally applied ointment has higher thick Degree, so it possesses, active constituent content is high, speed of separating out is slow, effect is long-term persistently, local efficacy The series of advantages such as conscientiously.Effective ingredient of the present invention can penetrate skin and produce promoting blood circulation and stopping painization silt, stimulates the menstrual flow away Network, the effects such as deep, expelling wind and cold of having one's ideas straightened out, the most comprehensive curative effect that plays for pathogenic characteristic, Improve perilesional histotrophic nutrition, play the effect repairing osteopathia tissue, be finally reached healing purpose.

For solving above-mentioned technical problem, the present invention provides the Chinese medicine for external application of a kind of cure scapulohumeral periarthritis, institute Stating the parts by weight of various crude drug in external preparation can be: Herba Epimedii 10～20 parts, the Cortex Eucommiae 10～20 Part, Radix Morindae Officinalis 10～20 parts, Fructus Psoraleae 10～20 parts, the Radix Linderae 10～20 parts, Radix Salviae Miltiorrhizae 10～20 parts, prolong Rhizoma Corydalis 10～20 parts, geranium 10～20 parts, Caulis Spatholobi 10～20 parts, the Radix Angelicae Dahuricae 10～20 parts, Herba Asari 10～ 20 parts, Olibanum (processed) 10～20 parts, Myrrha 10～20 parts, Radix Clematidis 10～20 parts, Radix Dipsaci 10～20 parts, Cortex Acanthopancis 10～20 parts, Herba Sarcandrae 10～20 parts, Caulis Trachelospermi 10～20 parts, Pheretima 10～20 parts, ground beetle Worm 10～20 parts, Rhizoma Drynariae 10～20 parts, Herba speranskiae tuberculatae 10～20 parts.

The Chinese medicine for external application of described cure scapulohumeral periarthritis, the weight of various crude drug in its described external preparation Number can also be: Herba Epimedii 10～15 parts, the Cortex Eucommiae 10～15 parts, Radix Morindae Officinalis 10～15 parts, Fructus Psoraleae 10～15 parts, the Radix Linderae 10～15 parts, Radix Salviae Miltiorrhizae 10～15 parts, Rhizoma Corydalis 10～15 parts, geranium 10～15 Part, Caulis Spatholobi 10～15 parts, the Radix Angelicae Dahuricae 10～15 parts, Herba Asari 10～15 parts, Olibanum (processed) 10～20 parts, do not have Medicine 10～20 parts, Radix Clematidis 10～20 parts, Radix Dipsaci 10～20 parts, Cortex Acanthopancis 10～20 parts, Herba Sarcandrae 10～ 20 parts, Caulis Trachelospermi 10～20 parts, Pheretima 10～20 parts, Eupolyphaga Seu Steleophaga 10～20 parts, Rhizoma Drynariae 10～20 parts, Herba speranskiae tuberculatae 10～20 parts.

The Chinese medicine for external application of described cure scapulohumeral periarthritis, the weight of various crude drug in its described external preparation Number can also be: Herba Epimedii 10～20 parts, the Cortex Eucommiae 10～20 parts, Radix Morindae Officinalis 10～20 parts, Fructus Psoraleae 10～20 parts, the Radix Linderae 10～20 parts, Radix Salviae Miltiorrhizae 10～20 parts, Rhizoma Corydalis 10～20 parts, geranium 10～20 Part, Caulis Spatholobi 10～20 parts, the Radix Angelicae Dahuricae 10～20 parts, Herba Asari 10～20 parts, Olibanum (processed) 10～15 parts, do not have Medicine 10～15 parts, Radix Clematidis 10～15 parts, Radix Dipsaci 10～15 parts, Cortex Acanthopancis 10～15 parts, Herba Sarcandrae 10～ 15 parts, Caulis Trachelospermi 10～15 parts, Pheretima 10～15 parts, Eupolyphaga Seu Steleophaga 10～15 parts, Rhizoma Drynariae 10～15 parts, Herba speranskiae tuberculatae 10～15 parts.

For solving above-mentioned technical problem, the present invention also provides for the Chinese medicine for external application of a kind of cure scapulohumeral periarthritis Preparation method, the dosage form of its described external preparation is liniment, and its preparation method includes:

A. the distillation of the Radix Linderae, the Radix Angelicae Dahuricae, Herba Asari, Olibanum (processed) and the Myrrha way of distillation is vaporized into white crystals；

B. by remaining raw material soaking in ethanol, heating and refluxing extraction 2 times, become component 1；

Take the medicinal residues after above-mentioned ethanol extraction the most again to add water, heating and refluxing extraction 2 times, become component 2；

D. by 2-in-1 to component 1 and component also, concentrate；The white crystals being mixed to get is dissolved in ethanol one-tenth liniment.

In described step a, the Radix Linderae, the Radix Angelicae Dahuricae, Herba Asari, Olibanum (processed) and the Myrrha way of distillation can be distilled Being vaporized into white crystals, pulverizer crosses 120 mesh dusting covers after pulverizing, and fine powder is standby.

In described step b, remaining raw material can be put into heating and refluxing extraction 2 times in ethanol, each 1～2 Hour, 2 extracting solution are merged and stands, remove supernatant, united extraction liquid, then through the molecular weight that dams be The ultrafiltration post ultrafiltration of 5000-10000, the extractum of 1.36 when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C, Heating is concentrated into paste, stand for standby use, becomes component 1.

In described step c, the medicinal residues that above-mentioned ethanol extraction is crossed can be added 10 times amount water heating and refluxing extraction 2 Secondary, each 1～2 hour, 2 extracting solution are merged and stands, remove supernatant, united extraction liquid, then warp The molecular weight that dams is the ultrafiltration post ultrafiltration of 5000-10000, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C The extractum of 1.36, heating is concentrated into paste, stand for standby use, becomes component 2.

In described step d, can insert double after decompression recycling ethanol by 2-in-1 also to said components 1 and component In effect vacuum concentrator, when being concentrated into 90 DEG C, relative density is the extractum of 1.05, is concentrated into every 1ml containing 1g Crude drug amount, then adds the crystalline powder that above-mentioned steps obtains, and is dissolved in ethanol one-tenth liniment after stirring.

For solving above-mentioned technical problem, the present invention reoffers the Chinese medicine for external application of a kind of cure scapulohumeral periarthritis Preparation method, described external preparation dosage form is unguentum, and its preparation process is: by Herba Asari, Olibanum (processed), do not have Medicine, Radix Clematidis and the distillation of the Radix Linderae way of distillation are vaporized into white crystals, and it is thin that pulverizer crosses 120 mesh after pulverizing Sieve, fine powder is standby；The most remaining raw medicinal material adds soak with ethanol 12 hours, and heating is boiled 30～40 minutes, Filtering, filtrate is standby；Filtering residue adds ethanol second time heating, boils 30～40 minutes, filters, and filtrate is standby With；Filtering residue adds water, for the third time heated and boiled 40～50 minutes, filters；Merge the extracting solution of three times, It is concentrated into the concentrated solution that relative density is 1.08；Filter, stand 24 hours, after remove supernatant, obtain paste Medicine；The white crystalline powder arrived above-mentioned steps distilled puts into paste, mixes vaseline and stirs, Tinning after sterilizing.

The Chinese medicine for external application of described cure scapulohumeral periarthritis, its described external drug dosage forms can be: spray, Ointment, tincture, unguentum, patch, herbal fumigation agent or Local out dressing gauze agent.

The present invention improves blood circulation, makes to fill blood, the waving of the medicine of cold-dispelling, promoting blood circulation to remove obstruction in the collateral, relaxing muscles and tendons The property sent out composition, through skin absorption, has dredging space between skin and muscles, the effect of blood circulation promoting and blood stasis dispelling；Make medicine effectively become simultaneously Divide the deep tissue directly penetrating into diseased region, utilize heating power to absorb arrival focus through transdermally people and give full play to Drug effect, plays pain relieving, detumescence, spasmolytic, minimizing adhesion and promotes the effect of healing, thus reaching treatment The purpose of disease.The present invention forms with pure traditional Chinese medicine, has bone and muscle strengthening, invigorating the liver and kidney, makes local vascular Expansion, blood fortune strengthens, and metabolism strengthens, and immunity improves, so that pain relief, promotes the suction of blood stasis Receive, play relaxing muscles and tendons and activating QI and blood in the collateral, consolidate eliminating evil, the effect of wind-expelling pain-stopping.

Detailed description of the invention

Chinese medicine is thought, the diseased region of primary disease at shoulder through normal pulse muscles along the regular meridians, the people of fifty-year-old, healthy energy is not Foot, seeks Wei Jianxu, if local experiences wind and cold, or tired sprain and contusion, or be accustomed to inclined side and crouch, muscle arteries and veins is subject to Oppression, then causes QI and blood retardance and forms shoulder numbness.With the passing of time, locally QI-blood circulation is not smooth, the QI and blood stasis of blood for shoulder pain Stagnant, so that affected part swelling adhesion, final joint stiffness, shoulder arm can not movement.

Chinese medicine is thought that primary disease is many and is defended weakness because of battalion, and muscles and bones is failed, multiple because of local experiences wind and cold, then causes gas Blood retardance forms shoulder pain.Modern medicine is thought, scapulohumeral periarthritis is shoulder soft tissue degeneration, causes shoulder joint There is the chronic aseptic inflammation that a kind of scope is wider in the joint capsule of joint and periarticular, soft tissue extensively glues Even, the activity of shoulder joint is limited.

Scapulohumeral periarthritis motherland medical science referred to as " scapulohumeral periarthritis ", " congealed shoulder ", " bursitis of shoulder " etc., be with shoulder joint Pain is main, first aches in paroxysmal, followed by moves a kind of commonly encountered diseases of obstacle, frequently-occurring disease.Suffer from Having the patient of scapulohumeral periarthritis, conscious have cold air to enter shoulder, also has patient to feel there is cold air inside shoulder joint Outwards emerge, therefore also known as " scapulohumeral periarthritis ".Its lesion characteristic is extensive, and i.e. pain is extensive, function limitation is wide The extensive scapulohumeral periarthritis of general, tenderness is moving back of a kind of capsula articularis humeri and surrounding ligaments, tendon and synovial bursa Row becomes and chronic nonspecific inflammation.It is chronic with shoulder arthralgia, limitation of activity as principal character Disease.

The present invention forms with pure traditional Chinese medicine, has bone and muscle strengthening, invigorating the liver and kidney, makes local vascular dilation, blood Fortune strengthens, and metabolism strengthens, and immunity improves.So that pain relief, promote the absorption of blood stasis, play Relaxing muscles and tendons and activating QI and blood in the collateral, consolidate eliminating evil, the effect of reducing swelling and alleviating pain.Effective ingredient of the present invention can penetrate skin and produce alive Blood and relieving painization silt, the network that stimulates the menstrual flow away, the effects such as deep, expelling wind and cold of having one's ideas straightened out, the most comprehensive for Pathogenic characteristic and play curative effect, improve perilesional histotrophic nutrition, play repair osteopathia tissue effect, It is finally reached healing purpose.The present invention uses kidney tonifying, essence replenishing in clinic, blood circulation promoting and blood stasis dispelling, removing obstruction in the collateral to relieve pain Treatment way treatment lumbar muscle strain have received preferable clinical efficacy.

The present invention improves blood circulation, makes to fill blood, the waving of the medicine of cold-dispelling, promoting blood circulation to remove obstruction in the collateral, relaxing muscles and tendons The property sent out composition, through skin absorption, has dredging space between skin and muscles, the effect of blood circulation promoting and blood stasis dispelling；Make medicine effectively become simultaneously Divide the deep tissue directly penetrating into diseased region, utilize heating power to absorb arrival focus through transdermally people and give full play to Drug effect, plays pain relieving, detumescence, spasmolytic, minimizing adhesion and promotes the effect of healing, thus reaching treatment The purpose of disease.

Rhizoma Corydalis: warm in nature, acrid in the mouth is bitter, enters the heart, spleen, liver, lung, be blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain it Quality goods, are world-famous for effect of pain relieving especially.Invigorate blood circulation；Dissipating blood stasis；Regulate the flow of vital energy；Pain relieving.Main trusted subordinate's waist knee joint All pains；Menoxenia；Lump in the abdomen；Metrorrhagia；Puerperal blood faints；Lochiorrhea；Traumatic injury.Coerce for breast, Epigastric pain, amenorrhea dysmenorrhea, postpartum stagnation, tumbling and swelling.Li Shizhen (1518-1593 A.D.) is concluded in Compendium of Material Medica Rhizoma Corydalis has " invigorate blood circulation, promoting the circulation of QI, pain relieving, diuresis " four large effects, and praise highly Rhizoma Corydalis " can the stagnation of QI in promoting the circulation of blood, Stasis in gas, therefore specially control upper and lower all pains all over the body "." Bencao Jingshu ": Rhizoma Corydalis, Wen Zeneng and smooth, With smooth then gas row；Xin Zeneng moistens and wanders away, and then blood of wandering away is lived.Blood lively atmosphere row, therefore can main removing blood stasis and puerperal All cause of disease blood persons of doing.The most uncomfortable person of married woman's menstruation, without he, disharmony between QI and blood, thus stagnate, then Can not with up to, and the card in many later stages is also.Luming in abdomen, puerperal blood faints, sudden and violent blood rushes to, because damaging hematochezia Deng card, all must QI and blood and then healing, therefore know lead also.Metrorrhagia drench dew, profit keep unfavorable walk, this most non-with The same use of the medicine that fills blood, has no that it can.

Pheretima: Compendium of Material Medica referred to as has dredge the meridian passage, blood circulation promoting and blood stasis dispelling, prophylactic treatment heart and brain blood Pipe disease effect.Pheretima taste cold in nature becomes.Function: heat clearing away, suppressing the hyperactive liver, Zhichuan, logical Lip river.Cure mainly high fanatical Dry, convulsion with spasms, headache due to pathogenic wind-heat, conjunctival congestion, hemiplegia etc..

Radix Salviae Miltiorrhizae is bitter, is slightly cold.GUIXIN, Liver Channel.Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness.For the moon Through uncomfortable, amenorrhea dysmenorrhea, lump in the abdomen, chest and abdomen twinge, pyretic arthralgia pain, skin infection swells and ache, vexed not Sleep.For costa sternales hypochondriac pain, rheumatic arthralgia, lump in the abdomen lumps, and skin infection swells and ache, and tumbling down is grieved, menoxenia, Amenorrhea dysmenorrhea, puerperal the stasis of blood pain etc..Treatment costa sternales pain, lump in the abdomen caking, and menoxenia, through amenorrhea Pain has good effect." detailed outline " carries: Radix Salviae Miltiorrhizae, and by " the sensible opinion of married woman " cloud, SIWU TANG controls gynecopathy, Paying no attention to antenatal puerperal, how many through water, the most generally applicable, only taste Radix Salviae Miltiorrhizae dissipates, and cures mainly same.Gai Dan Ginseng can break stagnated blood, mends fresh blood, and peaceful tire, fall stillborn fetus, only metrorrhagia dysentery, regulating menstruation arteries and veins.Radix Salviae Miltiorrhizae mainly becomes Point TANSHINONES has expansion blood vessel, improves circulation, releases the effects such as intravascular coagulation, have invigorating blood circulation trace it Effect, and can promote that liver blood circulates, beneficially liver cell regeneration.

Rhizoma Drynariae is bitter, temperature.Return kidney, Liver Channel.Function the kidney invigorating bone strengthening, continues and hinders pain relieving.For lumbago due to renal deficiency, Hiccough and deaf, odontoseisis, falling winks frustrates, injured bone；External treatment alopecia areata, vitiligo." solar corona Book on Chinese herbal medicine " carry it: control malignant boil, lose rotten meat, parasite killing.

Fructus Psoraleae acrid in the mouth；Bitter in the mouth；Warm in nature return through kidney；Pericardium；Spleen；Stomach；Lung meridian function cures mainly: mend Kidney is supporing yang；Helping inspiration to relieve asthma；Warming spleen and stopping diarrha.Main insufficiency of kidney-YANG；Below element deficiency and cold；Chills and pain of the waist and kness；Sexual impotence essence； Frequent micturition；The enuresis；Failure of the kidney in receiving QI；Dyspnea due to deficiency is more than；Asthenia of both the spleen and kidney；Stool chronic diarrhea." Bencao Jingshu ": Fructus Psoraleae, can warming the kidney；Raw sun in the moon, the key medicine of excessive fire benefit soil is also.Its main five kinds of strain and seven kinds of impairment, Gai Yuanlao The disease of wound, arises from asthenia of both the spleen and kidney more, with its can warming the kidney, mend fire with the raw-soil, then being so incensed that of kidney-Yang in kidney Mend and rise, then can digesting food, steam waste matter and change precise and tiny.It is attributed to lung on spleen-QI transporting the essence to the whole body, supports with honor The five internal organs, therefore the labor of main the five internal organs.Seven emotions hinder disease of viscera connecting with this channel.Wind cold caused by deficiency person, because yang-energy is decayed, the most air-cooled takes advantage of Empty and visitor's so that bone marrow wound loses, kidney cold essence stream, kidney governing bones and store essential substances, marrow be essence originally, kidney-Yang it Gas is solid, and i.e. front card is shown in, Gu and its yang-energy is raw, then and front card removes in vain.Man based on essence, married woman Based on blood, married woman vim and vigour person, the most still man's sun kidney that declines is cold and be the disease of blood prostration QI collapse caused by exhaustion of QI of the spleen and kidney, with man it Kidney cold essence stream is also.

Radix Dipsaci, Chinese medicine name, for the root of Dipsacaceae herbaceos perennial Radix Dipsaci, because of energy, " continuous folding connects Bone " and gain the name.Autumn excavates, and removes root head and fibrous root, is dried to low baking temperature half-dried, and bank up " diaphoresis " is to interior During portion's virescence, then dry." the southern regions of the Yunnan Province book on Chinese herbal medicine ": " meridians are determined in tonifying liver, bone and muscle strengthening, only (muscle in warp Bone) ache, antiabortive, control married woman leucorrhea, tissue regeneration promoting blood, removing blood stasis with potent drugs blood, fall stillborn fetus, and cough-relieving is coughed hemoptysis, controls red White turbid urine.”

Rhizoma Chuanxiong is pungent, temperature.Enter liver, gallbladder meridian.Activating QI to alleviate the depression, method wind-dryness is wet, promoting blood circulation and stopping pain.Control air-cooled head Pain rotation is dizzy, and hypochondriac pain abdomen aches, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation block pain, ulcer sores.With In menoxenia, amenorrhea dysmenorrhea, abdominal mass stomachache, breast side of body twinge, tumbling and swelling, headache, rheumatic arthralgia. " herbal classic " carries it: main apoplexy enters brain headache, arthralgia due to cold, clonic spasm of the muscle emergency, and gold wound, married woman's blood closes loss of fecundity. " not Lu " carries it: " except cold dynamic in brain, on face, urticaria goes, mesh lacrimation, profuse nasal discharge and spittle, before we notice it the most liquor-saturated, All cold gas, trusted subordinate's heavily fortified point pain, attacked by pestiferous factors, soldier is anxious to swell and ache, side of body wind pain, warming middle-JIAO endogenous cold." it is regulating qi to disperse stagnation Good medicine.

Caulis Piperis Kadsurae: latin name CAULIS PIPERIS KADSURAE.Caulis Piperis Kadsurae is dicotyledon medicine The rattan of Piperaceae plant pipex kadsura.Medical material is the rattan of Piperaceae plant pipex kadsura, nature and flavor Gui Jing is pungent, bitter, tepor.Return Liver Channel.Effect is temperature of dispeling the wind, the meridian dredging.Can treat for wind and cold Arthralgia chiefly caused by damp pathogen, articular instability, lumbocrural pain, muscle arteries and veins contracture.Lung cold is breathed with cough, joint stuffiness." book on Chinese herbal medicine is the newest ": Passing through network, and blood vessels, alleviating distention in middle-JIAO is regulated the flow of vital energy, under wet except wind, manage waist tinea pedis, control hernia, antiabortive." Kai Baoben Grass ": main air blood, mend aging, play sun, strong waist foot, eliminating impediment, bleach, by cold air, air draft is evil.Also Liquor takes, and also infusing drugs in wine clothes, use it the eleventh month of the lunar calendar." Bencao Tujing ": control lumbago.

Radix Morindae Officinalis is pungent, sweet, tepor.Effect reinforcing the kidney and supporting YANG；Expelling wind and removing dampness；Bone and muscle strengthening.Cure mainly and suffer from a deficiency of the kidney Sexual impotence；Seminal emission premature ejaculation；Few abdomen cold type of pain；Incontinence of urine；Cold womb is infertile；Anemofrigid-damp arthralgia；Soreness of the waist and knees； Rheumatism limb gas." book on Chinese herbal medicine is looked for the truth ": Radix Morindae Officinalis, is referred to as the kidney invigorating according to book and wants agent, can control infirmities and diseases, by force Cloudy benefit essence, with its body profit event ear.So pungent temperature of abnormal smells from the patient, again can expelling wind and removing dampness, therefore all lumbocrural pains, pathogenic wind The diseases such as tinea pedis edema, clothes the most useful.True dihuang drink is kept in sight, with this to control ailment said due to cold or exposure, the real base of justice this, Nourishing YIN opinion cannot not be specially used as also." herbal classic ": main strong wind pathogen, impotence does not rises, bone and muscle strengthening, settling five organs, Invigorating middle warmer increases will QI invigorating.

Cortex Acanthopancis Chinese medicine Cortex Acanthopancis has the effects such as wind-damp dispelling, invigorating the liver and kidney, bone and muscle strengthening.Compendium of Material Medica Described in: " dispelling the wind and dampness pathogens flaccidity syndrome and arthralgia syndrome, strengthening bone and muscle." modern study, this product also have antitumor, resisting fatigue, Reduce the effect such as whole blood viscosity, atherosclerosis formation.Cortex Acanthopancis is easy to use, decocts soup, enters Ball, scattered or infusing drugs in wine, but hyperactivity of fire caused by deficiency of YIN person is cautious use of.(2 " Bencao Jingshus ": Cortex Acanthopancis see " this Warp " led all cards, all because of wind-cold damp pathogen hinder in (few cloudy, the moon of fainting of foot) two through therefore, and dampness is particularly The most also." warp " cloud, hinders in wet person, lower first by it.Cloud again, water-damp from the earth, feel then victimization skin and flesh muscle Arteries and veins.How main muscles and bones under Liver and kidney occupies, therefore the heresy that wind and cold is wet, be subject to through first from two, and the pungent energy of this medicine dissipates wind, temperature Can except cold, bitter can dampness, two its gas dirty and all cards know recover.Dampness contamination, then the five internal organs muscle moderate pulse again Vertical；During dampness stays, then empty win gas is weary.Damp was both gone, then in Jiao control and muscles and bones from hard, gas day by day and in Self-complementary also.Its main strong will person of benefit essence, the kidney storing the essence and will is also.

Caulis Trachelospermi (ChineseStarjasmineStem), calls red Caulis Trachelospermi, Radix Clematidis terniflorae, for Folium seu Cortex Nerii The leaf bine stem of section's plant trachelospermum jasminoide.Cold nature, bitter in the mouth.Dispelling wind and removing obstruction in the collateral, removing heat from blood is subsided a swelling.For rheumatic fever Numbness, muscle arteries and veins contracture, soreness of waist and knee joint, sore throat, carbuncle, injury from falling down.Hardship, is slightly cold.GUIXIN, liver, Kidney channel.There is expelling wind and removing dampness, removing obstruction in the collateral to relieve pain, clearing away heat and cooling blood, effect of removing toxic substances and promoting subsidence of swelling, cure mainly dispel the wind logical Network, removing heat from blood is subsided a swelling.For beriberoid pyretic arthralgia, muscle arteries and veins contracture, soreness of waist and knee joint, sore throat, carbuncle, fall and flutter damage The effect of wound." key medicine divides agent ": the merit of trachelospermum jasminoide, specially in relaxing muscles and tendons and activating QI and blood in the collateral.All patient's muscle arteries and veins contractures, no Easily stretch person in the wrong, clothes invariably obtain effect, can not neglect also." book on Chinese herbal medicine justice ": trachelospermum jasminoide abnormal smells from the patient, " herbal classic " The bitter temperature of meaning, lid invigorate blood circulation with function the meridian dredging for it, therefore think temperature.So " herbal classic " cures mainly, and pure is Heat symptom-complex, the most non-warm understands, therefore " not Lu " transforms into and be slightly cold, and " for the emperor's inspection " draws that Lee works as says, and with For Great Cold also.This thing is apt to walk passages through which vital energy circulates, sensible podomere, the dead flesh of " herbal classic " main air heat, " not record " foster kidney, Main waist hip pain, hard muscle, profit joint, all i.e. this justice.It controls carbuncle, mouthpiece swells, xerostomia scorching tongue, all bitter The function of diarrhea due to cold pathogen fall is also.

Eupolyphaga Seu Steleophaga becomes, and has effect of removing blood stasis, reunion of fractured tendons and bones, and has thrombolytic mechanism.Cold；Have Mild toxicity.Return Liver Channel.Function cures mainly removing blood stasis with potent drugs blood, reuniting the fractured tendons and bones.For injured bone, blood stasis amenorrhea, lump in the abdomen Mass in the abdomen." Medical Treasures of the Golden Chamber ": control the patient suffering from five overstrains being extremely weak and thin, abdominal distention, it is impossible to diet, dyspepsia, sad, drink Wound, injury due to sexual activity, internal impairment caused by hunger, impairment caused by overstrain, meridians Rong Wei impairment of QI, blood stasis in the interior, squamous and dry skin, dark complexion around the eyes. Easing middle-JIAO and tonifying for deficiency.

Herba Epimedii is pungent, sweet, warm, returns liver, kidney channel.Energy reinforcing the kidney and supporting YANG, strengthening the tendons and bones, expelling wind and removing dampness, It is apt to control insufficiency of kidney-YANG, impotence and seminal emission, enuresis frequent micturition；Rheumatic arthralgia, atrophic debility of bones paralysis disease." book on Chinese herbal medicine is stated " cloud " excessive sheep is fiery, and the main impotence of " herbal classic " medicine is hindered absolutely, and " solar corona " also its treatment of first speech man is the most positive, woman The most cloudy, then calling into the gate of vitality, benefit kidney-Yang person is also.Lid the gate of vitality be the vigour of the kidney-Yang in kidney, the i.e. person also, Its so-called YANG exhaustion absolutely is cloudy, the not vigour of basis, how hiss in the most withered.So-called physical strength profiting, Qiang Zhi, and control Cold air consumptive disease, the cards such as muscles and bones contraction is anxious, all it helps the event of vigour.The octogenarian of old man's dusk, the middle age is forgetful, all Yuanyang Decay and can not ascensionist also.This taste of notice is to reduce to rise, and its liter is owing to dropping also.

The Cortex Eucommiae is sweet micro-pungent, temperature.The Cortex Eucommiae is the Eucommiaceae plant Cortex Eucommiae (Eucommia ulmoides Oliver) Dry bark, be Chinese famous and precious tonic herb.Tool invigorating the liver and kidney, bone and muscle strengthening, blood pressure lowering, antiabortive etc. all Many effects.Shennong's Herbal is classified as top grade.Call it and " cure mainly waist and knee, invigorating middle warmer, benefit vital essence, heavily fortified point Muscles and bones, wet except itching under the moon, dribbling urination.For a long time clothes, make light of one's life by commiting suicide resistance to always.The Cortex Eucommiae has an invigorating the liver and kidney, bone and muscle strengthening, Rubbish in purged body, strengthens human body cell substance metabolism, prevents muscle skeleton aging, balanced human's blood pressure, Decomposer inner cholesterol, reduction body fat, recovery blood vessel elasticity, diuresis heat clearing away, broad-spectrum antiseptic, emerging Put forth energy nervus centralis, improve white blood cell count, strengthen the remarkable efficacy such as body immunity." beautiful Chinese catalpa medicine solution ": Liver and kidney tonifying, nourishing muscle and tendon bone, goes to joint wet excessive, controls soreness of waist and knee joint, lower limb foot contracture." book on Chinese herbal medicine is the newest ": fill Biceps, Yang path strenghtening.

Herba Sarcandrae slightly warm in nature, bitter in the mouth, pungent.Function cures mainly anti-inflammation, dispelling wind and removing obstruction in the collateral, blood circulation promoting and dispersing pathogen accumulation. For pneumonia, appendicitis, cellulitis, rheumatic arthralgia, injury from falling down, tumor.Herba Sarcandrae is gold The herb of foxtail millet the orchid family Herba Sarcandrae, has another name called Herba Pileae Scriptae, Herba Pileae Scriptae, Ramulus Sambuci Williamsii etc..It is that the provinces such as Jiangxi are rare One of Chinese crude drug.Acrid in the mouth, hardship, property is put down.There are anti-inflammation, heat-clearing and toxic substances removing, expelling wind and removing dampness, work Blood and relieving pain, effects such as synthetism of stimulating the menstrual flow, be used for treating various diseases associated with inflammation, rheumatic arthritis, skin infection Toxic swelling, traumatic injury.Fracture etc..

Geranium is bitter, for pungent, flat.Returning liver, kidney, large intestine channel, function cures mainly remove rheumatism.For wind Pain of dampness syndrome.The disease such as numb limbs and tense tendons, articular instability, alone effectively, be decocted in water for oral dose or endure cream use；Such as compatibility osmanthus The medicines such as branch, Fructus Anisi Stellati, Flos Carthami, Radix Paeoniae, can strengthen the effects such as promoting blood circulation, dredging meridian and relieving pain.

Radix Clematidis expelling wind and removing dampness, removing obstruction in the collateral to relieve pain, expectorant water, dissipate the hypochondriac lump.Cure mainly gout insensitive impediment, rheumatism Arthralgia pain, numb limbs and tense tendons, chills and pain of the waist and kness, muscle arteries and veins contracture, joint stuffiness, tinea pedis, malaria, lump in the abdomen, Tetanus, tonsillitis, all a fishbone or other bone caught in the throat swallow." Kaibao Bencao ": main all wind, logical five Tibetan of a surname, in removing abdomen Cold stagnant, septum cordis expectorant water amasss for a long time, lump in the abdomen Xuan tinea air parcel, bladder place pus aversion to water, the cold pain of waist knee joint and treatment injured.

Olibanum (processed) is worked hard, temperature.Regulating qi and activating blood, analgesic therapy, chase after poison.Control coagulation of QI-blood, trusted subordinate's pain, carbuncle Pyogenic infections from tumour or sore, traumatic injury, dysmenorrhea, postnatal blood stasis twinge." not Lu ": treat edema due to wind pathogen poison and swell, remove bad odor. Treat urticaria to itch poison.Supplement to the Herbal: treat deafness, apoplexy locked mouth, married woman's vim and vigour, wine can be sent out, reason Air-cooled, only large intestine is let out, and treats all skin ulcers and makes internal diabetes.

Myrrha cure mainly chest and abdomen stasis of blood pain, dysmenorrhea, amenorrhea, lump in the abdomen, traumatic injury, carbuncle skin infection, acute appendicitis, Conjunctival congestion and swelling pain.There is the effect such as promoting blood circulation and stopping pain, detumescence and promoting granulation." book on Chinese herbal medicine warp ", Myrrha bitter in the mouth is put down nontoxic. So flat should make pungent, gas should be slightly cold.All malignant boil anal fistula, all forms because the heat in blood stasis of blood is stagnant, outer by gold sword and flogging trauma Making skin ulcer, the most all flesh and blood is by disease.Flesh and blood is hindered, the stasis of blood and generate heat and have a pain, this medicine hardship can be let out, and pungent energy dissipates, cold energy Heat extraction.Water belongs to the moon, and blood also falls within the moon, with class from, therefore blood system can be entered, dissipating blood stasis blood, control all skin ulcers of heat in blood and The most lower blood disorder of soldier is also.Liver Channel heat in blood, then mesh be also pain, skin nebula, dissipate Liver Channel heat in blood, then mesh disease is removed.

Herba Asari cures mainly: dispel the wind, cold expelling, row water, has one's ideas straightened out.Control air-cooled headache, nasal sinusitis, toothache, phlegm retention Cough with dyspnea, rheumatic arthralgia.All herbal medicine, with for antipyretic, diuresis, analgesia, tranquilizer.Control headache, have Diaphoresis, the effect eliminated the phlegm.Exterior syndrome due to wind-cold；Headache, toothache；Rheumatic arthralgia；Phlegm retention cough with asthma；Nasal obstruction；Nose Deep pool；Aphtha.Refrigeration function Herba Asari volatile oil gavages many reasons such as temperature acupuncture manipulation, tetrahydrochysene beta-naphthylamine, wound Rabbit experiment heat pyrexia caused by cold, paratyphoid fever mixed vaccine has obvious refrigeration function, to medicated beer ferment Rat fever caused by mother also has obvious antipyretic response.The body temperature of normal rat can also be reduced.

Caulis Spatholobi: property is bitter, sweet, temperature.Return liver, kidney channel, enrich blood, invigorate blood circulation, dredging collateral.For menstruation not Adjust, blood deficiency and yellow complexion, paralysis and numbness, rheumatic arthralgia relaxing muscles and tendons to promote blood circulation；Nourishing blood for regulating menstruation, supplementary Amplifications of the Compendium of Materia Medica Carry it and can cure numb hand and foot；Quadriplegia；Rheumatic arthralgia；Women has through uncomfortable；Dysmenorrhea.

Radix Angelicae Dahuricae meridian distribution of property and flavor: pungent, temperature.Attach to the lung and stomach meridians.Expelling wind and cold, sensible pain relieving, detumescence row Pus, dampness leukorrhagia stopping." Japan hanako materia medica ": control conjunctival congestion bulbar conjunctiva polyp, and tire patching leakage landing, broken stagnated blood, mend Fresh blood, acute mastitis, carbuncle on the back, scrofula, hemorrhoidal hamorrhage, hemorrhoid complicated by anal fistula, evacuation of pus, desolation, scabies, pain relieving granulation promoting, go Face defect scar.

Herba speranskiae tuberculatae sweet, acrid, warm.Expelling wind and removing dampness, the pungent temperature of these product, pungent energy be manageed it scattered, and temperature overcomes the coldness wet.Eight livers Warp, therefore energy expelling wind and removing dampness, as Compendium of Material Medica is said: Herba speranskiae tuberculatae " controls all rheumatalgia contractures of muscles and bones.” If causing limbs pain because of wind-cold damp pathogen invasion and attack limbs meridians, numb, joint stuffiness.Can be selected for this product, Expelling wind and cold victory is wet, and pathogenic factor goes, the most all disease spontaneous recovery.Relaxing muscles and tendons and activating QI and blood in the collateral, the pungent scattered temperature of these product is logical, enters Liver Channel, And liver governing tendons. therefore these product have effect of relaxing muscles and tendons and activating QI and blood in the collateral.For the heresy of affection of exogenous wind-cold, losing a surname through gas, disease is seen Limbs muscle arteries and veins shrinks takes out urgency, it is impossible to relaxes and turns freely.Can be selected for Herba speranskiae tuberculatae, expelling wind and cold, relaxing muscles and tendons and activating QI and blood in the collateral is controlled It.As " the sweet peaceful blue or green Chinese herbal medicine choosing in Shan " i.e. selects these product, control muscles and bones contracture.

Radix Linderae gas is fragrant, mildly bitter flavor, pungent, has refrigerant sense." Radix Linderae, the male temperature of gas, therefore fast gas a surname is logical, Evacuate and stagnate, more than Rhizoma Cyperi.Induce sweat outward and manage flesh, interior alleviating distention in middle-JIAO and pleasant.With cold expelling gas, then visitor is cold Cold type of pain is from removing；Get rid of evils gas then sky row epidemic disease miasma the most but；Dissipating depression of QI gas, attacked by pestiferous factors stomachache, chest and diaphragm distension, suddenly may be used Subtract；Dredging through gas, apoplexy extremity are unsuccessful, and primiparity vim and vigour stagnate, and gradually can lead to, and all the merit of its gas hero of mat is also.” (" medicineization justice ")

The manufacturing process of liniment of the present invention is:

Radix Linderae 1000g, Radix Angelicae Dahuricae 1000g, Herba Asari 1000g, Olibanum (processed) 1000g and Myrrha 1000g are first used Way of distillation distillation is vaporized into white crystals, and pulverizer crosses 120 mesh dusting covers after pulverizing, and fine powder is standby.

By remaining raw material Herba Epimedii 1000g, Cortex Eucommiae 1000g, Radix Morindae Officinalis 1000g, Fructus Psoraleae 1000g, pellet Ginseng 1000g, Rhizoma Corydalis 1000g, geranium 1000g, Caulis Spatholobi 1000g, Radix Clematidis 1000g, Radix Dipsaci 1000g, Cortex Acanthopancis 1000g, Herba Sarcandrae 1000g, Caulis Trachelospermi 1000g, Pheretima 1000g, Eupolyphaga Seu Steleophaga 1000g, Rhizoma Drynariae 1000g, Herba speranskiae tuberculatae 1000g, put into heating and refluxing extraction 2 times in ethanol, each 1～2 hour, 2 extracting solution are merged and stand, remove supernatant, united extraction liquid, then through the molecular weight that dams be 5000-10000 Ultrafiltration post ultrafiltration, the extractum of 1.36 when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C, heating is concentrated into Paste, stand for standby use, become component 1.The medicinal residues that above-mentioned ethanol extraction is crossed add 10 times amount water heat back Stream extracts 2 times, each 1～2 hour, 2 extracting solution is merged and stands, and removes supernatant, united extraction liquid, The ultrafiltration post ultrafiltration that molecular weight is 5000-10000 through damming again, ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C time 1.36 extractum, heating be concentrated into paste, stand for standby use, become component 2.By said components 1 2-in-1 with component also insert after decompression recycling ethanol in economic benefits and social benefits vacuum concentrator, be concentrated into when 90 DEG C relative Density is the extractum of 1.05, is concentrated into every 1ml crude drug amount Han 1g, then adds the crystal powder that above-mentioned steps obtains End, stirs, and adds ethanol, becomes liniment.

The preparation process of unguentum of the present invention:

First by Radix Linderae 1200g, Radix Angelicae Dahuricae 1300g, Herba Asari 1200g, Olibanum (processed) 1100g and Myrrha 1200g, Way of distillation distillation is vaporized into white crystals, then by Herba Epimedii 1200g, and Cortex Eucommiae 1200g, Radix Morindae Officinalis 1100g, Fructus Psoraleae 1200g, Radix Salviae Miltiorrhizae 1200g, Rhizoma Corydalis 1100g, geranium 1200g, Caulis Spatholobi 1100g, prestige Radix Clematidis 1100g, Radix Dipsaci 1200g, Cortex Acanthopancis 1100g, Herba Sarcandrae 1100g, Caulis Trachelospermi 1200g, Pheretima 1100g, Eupolyphaga Seu Steleophaga 1100g, Rhizoma Drynariae 1200g, Herba speranskiae tuberculatae 1200g, add the immersion 1-2 of 5-10 times amount water Hour, heating extraction 2 times, each 1-2 hour, remove supernatant, united extraction liquid, 80-120 mesh filters, The ultrafiltration post ultrafiltration that molecular weight is 5000-10000 through damming again, ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C time 1.36 extractum, heating concentrate, 30 minutes～45 minutes, extract active ingredient, concentrated solution is quiet Being set to extractum shape, mass continues heating and is concentrated into extractum shape, stand for standby use, becomes component 1；Medicinal residues add 5-10 Times amount 60-90% ethanol water soaking 1-2 hour, extracts 1 time, as component 2 for 1-1.5 hour；By above-mentioned group Point 1 2-in-1 also with component, inserts in economic benefits and social benefits vacuum concentrator, be concentrated into 90 DEG C of phases after decompression recycling ethanol It is the extractum of 1.05 to density, is concentrated into every 1ml crude drug amount Han 1g, then passes to spray dryer and spray Mist is dried, and the compressed air pressure crossing spray dryer shower nozzle is 5kg/m², hothouse hot stream temperature is 100 DEG C, obtain raw material medicated powder and remerge the white crystals adding vaporization, stir after adding vaseline mixing.

The preparation method of spray of the present invention: first by Radix Linderae 1200g, Radix Angelicae Dahuricae 1300g, Herba Asari 1200g, Olibanum (processed) 1100g and Myrrha 1200g, way of distillation distillation is vaporized into white crystals；Then by Herba Epimedii 1300g, Cortex Eucommiae 1200g, Radix Morindae Officinalis 1100g, Fructus Psoraleae 1200g, Radix Salviae Miltiorrhizae 1200g, Rhizoma Corydalis 1100g, Geranium 1200g, Caulis Spatholobi 1100g, Radix Clematidis 1300g, Radix Dipsaci 1100g, Cortex Acanthopancis 1100g, swollen Joint wind 1200g, Caulis Trachelospermi 1200g, Pheretima 1100g, Eupolyphaga Seu Steleophaga 1300g, Rhizoma Drynariae 1200g are deep Grass 1200g, puts into heating and refluxing extraction 2 times in ethanol, each 1～2 hour, merges quiet by 2 extracting solution Put, go supernatant, united extraction liquid, then the ultrafiltration post ultrafiltration that molecular weight is 5000-10000 through damming, The extractum of 1.36 when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C, heats and is concentrated into paste, stand for standby use, Become component 1.The medicinal residues that above-mentioned ethanol extraction is crossed are added 10 times amount water heating and refluxing extraction 2 times, each 1～ 2 hours, 2 extracting solution are merged and stands, remove supernatant, united extraction liquid, then through the molecular weight that dams be The ultrafiltration post ultrafiltration of 5000-10000, the extractum of 1.36 when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C, Heating is concentrated into paste, stand for standby use, becomes component 2.By 2-in-1 also to said components 1 and component, decompression Inserting in economic benefits and social benefits vacuum concentrator after reclaiming ethanol, when being concentrated into 90 DEG C, relative density is the extractum of 1.05, It is concentrated into every 1ml crude drug amount Han 1g, then adds the crystalline powder that above-mentioned steps obtains, fill after stirring Enter in medical spray gun.

The preparation method of external use plaster of the present invention is: first by Radix Linderae 1100g, Radix Angelicae Dahuricae 1200g, Herba Asari 1100g, Olibanum (processed) 1200g and Myrrha 1300g, way of distillation distillation is vaporized into white crystals；The most just Herba Epimedii 1300g, Cortex Eucommiae 1200g, Radix Morindae Officinalis 1100g, Fructus Psoraleae 1200g, Radix Salviae Miltiorrhizae 1200g, Rhizoma Corydalis 1100g, Geranium 1200g, Caulis Spatholobi 1100g, Radix Clematidis 1300g, Radix Dipsaci 1100g, Cortex Acanthopancis 1100g, swollen Joint wind 1200g, Caulis Trachelospermi 1200g, Pheretima 1100g, Eupolyphaga Seu Steleophaga 1300g, Rhizoma Drynariae 1200g are deep Grass 1200g, adds in the Oleum Sesami of 5-10 times of weight portion and soaks 7-10 days, and heating extraction effective ingredient, big fire is boiled Boiling, after Oleum Sesami boiling, firepower reduces, endure to pharmaceutical presentations be dark brown, internal coke yellow, pull medicinal residues out, Continuing to temper by medicine oil, and be stirred continuously, refining is to beading of dripping；Plumbum preparatium is fried to vermilion, removes water Point, cross 100-120 mesh sieve and remove impurity；Plumbum preparatium is slowly added in the medicine oil refined, is stirred continuously, become The thick paste of black, the plaster refined adds the crystalline powder of pulverizing and stirs, the coldest after be poured in cold water, Soak 5-10 days, change water every day once, releasing fire-toxin；Put into harmless adhesive plaster after patent medicine and become plaster, outward With.

Pharmacological toxicity is tested

1. irritation test

Take rabbit shaving, carry out inducing and exciting contact test with externally-applied liniment of the present invention, at 24 hours and Viewing test rabbit after 48 hours, all loseing skin has the phenomenon such as erythema and edema, with negative control group without Difference.Result shows, this patch is bordering on zero to dermoreaction intensity, i.e. without skin allergic reaction.

2. use allotransplantation in rats passive cutaneous anaphylaxis, PCA (PCA), dinitrochlorobenzene (DNCB) to induce little Mus Tardive allergy model, observe the present invention to allotransplantation in rats passive cutaneous anaphylaxis, PCA (PCA), The impact of mice delayed hypersensitivity (DTH), result shows that the Chinese medicine health care product of the present invention can suppress big Mus passive cutaneous anaphylaxis, PCA of the same race and mice delayed hypersensitivity；The Chinese medicine health care product of the present invention is to two Toluene induced mice auricle edema and the impact swelling the cause of rat paw carrageenin, all show substantially Antiinflammatory action；To histamine, dextran caused Cavia porcellus respectively, mouse skin is scratched where it itches also has significantly Inhibitory action.

3. acute toxicity test

Give white mouse oral administration medicine supplying with this product with 300 times of clinical consumption per day, observe 5.The all animals of result Strong depositing, its activity, diet, hair, Excreta are no abnormal, have no toxic reaction.White mouse is broken Damage skin and carry out irritation test, there are no irritative response and other untoward reaction.

Toxicity test proves, the most toxic effect of this medicine and untoward reaction, clinical practice is safe and reliable.

4. long term toxicity test:

Mice is pressed 7.69,19.18 and 43.21g crude drugs/kg continuous use 15 weeks by health product of the present invention After (1.0ml/100g body weight, every day 2 times) and drug withdrawal 3 weeks, result shows: health product of the present invention are to rat Hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat etc. refer to Mark all has no significant effect, and internal organs naked eyes do not find that difference change and histological indications show, medication After 15 weeks and drug withdrawal 3 weeks, each internal organs of rat are all without substantially changing.Illustrate that health product of the present invention are to rat length After phase medication, toxicity is little, does not also have difference reaction, application safety after drug withdrawal.

External used medicine of the present invention repeatedly Skin Irritation Test result

According to DB61-267-1998's " health product Toxicological evaluation program and the method for inspection " Requirement, has carried out repeatedly Skin Irritation Test to medicine of the present invention.

Tested material: the unguentum of the present invention.Weigh tested material 50g to add distilled water to make 50% pastel standby.

Laboratory animal: provided Japan's white big ear rabbit 4 by Shandong University's medical college Experimental Animal Center, Male and female half and half, body weight 2.5-3.0kg, primary animal (the dynamic word the 08-018th of doctor), feed resource is ibid.Dynamic Thing room environmental: temperature: 22-25 DEG C, relative humidity: 45-55%.The Animal House quality certification number: the dynamic word of doctor No. 08-37.Test method: test first 24 hours, in every rabbit back spinal column both sides cropping preserved skin, goes The hair each 3cm × 6cm of scope.Only take tested material 0.5g/, be coated in after preparation on the skin of every rabbit side, every day Smearing once, offside all makees solvent control.Smear 14d continuously.Cropping before being coated with every day, must not damage skin Skin, it is ensured that tested material is fully contacted with skin.Observe dermoreaction and marking every day.Off-test, takes Smear area skin and carry out histopathologic examination.

Experimental result: repeatedly Skin Irritation Test show the present invention the highest stimulation index of repeatedly skin irritation and Pathological tissue integration is 0, according to DB61-267-1998 " health product Toxicological evaluation program And the method for inspection " in skin irritation strength grading standard, the present invention repeatedly skin irritation intensity belongs to non-stimulated Property.

Skin anaphylactic test

According to DB61-267-1998's " health product Toxicological evaluation program and the method for inspection " Requirement, has carried out skin anaphylactic test to medicine of the present invention.

Tested material: externally used paste of the present invention.Weigh tested material 10g to add distilled water to make 50% pastel standby With.Positive control: 2,4-dinitro-chloro-benzenes, Xing Jin chemical plant, Beijing product, lot number 20020522. Laboratory animal: provided Cavia porcellus 30, male and female half and half, body weight by Shandong University's medical college Experimental Animal Center 250-300g, primary animal, feed resource is ibid.Animal housing's environment: temperature: 22-25 DEG C is the wettest Degree: 45-55%.The Animal House quality certification number: the dynamic word the 08-37th of doctor.Test method: Cavia porcellus will be tested It is randomly divided into three groups, often group 10, male and female half and half, respectively tested material group, negative control group and the positive Matched group.

Sensitization contact: being removed by guinea pig back left of spine hair for first 24 hours to tested material, unhairing scope is about 3cm×3cm.Only take tested material 0.2g/, be coated in depilation district on the left of back part of animal after preparation, continue 6 little Time.7th day and fortnight, be repeated once with same method, and positive controls is coated with 1%DNCB, cloudy Property matched group does not deals with.Excite contact: fortnight after last is to tested material, by tested material 0.2g/ only, It is coated on depilation district on the right side of guinea pig back after preparation, after 6 hours, removes tested material, at once observe allergy anti- Answer situation, then again observed in 1,24,48,72 hours.Positive controls is coated with 1%DNCB, cloudy Property matched group does not deals with.Observational technique is with tested material group.

Result of the test: skin anaphylactic test shows patch of the present invention, " protects according to according to DB61-267-1998 Strong articles for use Toxicological evaluation program and the method for inspection " in relevant sensitization of skin intensity evaluation standard, The invention belongs to without sensitization.

Pharmacological experiment

1, conduction of heat causes mice to intend pain reaction (hot plate method) experiment

One-level ICR mice, body weight 18～22g, female；RB-200 intelligence hot-plate instrument, program control temperature 55 ± 0.5 DEG C, licking metapedes for induced pain index with mice, the time used when there is licking metapedes is its threshold of pain Value, measures each Mus normal pain threshold, the damp normal pain threshold mice between 5～30s 50 of choosing, at random Being divided into 5 groups, often group 10, packet and administrations are shown in Table 1.

The impact of mouse hot-plate induced pain is tested and is administered and packet situation by table 1

Measuring after normal pain threshold, each treated animal is administered by upper table, smears, after administration 30,60,90min (just Flos Carthami line of oils is 15,60,90min) measure pain threshold after each Mus is administered respectively, calculate the threshold of pain and improve percentage Rate.Statistical procedures: using SPSS10.0 software one factor analysis of variance to add up, data result is used Mean plus-minus standard deviation (x ± s) represents.The results are shown in Table 2

The table 2 impact on mouse hot-plate induced pain

Compare with blank group, * * * p ＜ 0.001；* p ＜ 0.01；* p ＜ 0.05.

Table 2 result shows, this product can significantly improve the pain threshold of hot plate induced pain mice, with blank group Relatively, dosage group p ＜ 0.05 high, middle during senior middle school's low dose group p ＜ 0.01,90min during 60min.Prompting High dose group of the present invention has obvious analgesic effect to hot plate induced pain mice.

2, xylol causes the impact of mice auricle swelling

Male ICR mouse 60, is randomly divided into model control group, positive controls, the present invention by body weight (liniment) high, medium and low dosage group, totally 5 groups, often group 12.Senior middle school low dose group rat is coated with respectively Smear the present invention 500,250,125mg/kg, positive controls smears ZHENGHONGHUA YOU 121mg/kg, model group Giving equal-volume normal saline, the biggest 1 time, continuous 7 days, last was administered latter 1 hour, by 50 μ l dimethylbenzene It is applied to two sides before and after every mouse right ear.After 4 hours, de-neck is put to death, and cuts ears, uses a diameter of 8mm Rustless steel punching pin sweeps away left and right auricle, weighs, using the difference of two auricle weight as the finger weighing swelling degree Mark, antiinflammatory action intensity represents with suppression ratio (%), carries out statistical analysis with SPSS11.5 software kit.Knot Fruit is shown in Table 3.

The table 3 impact (x ± s) on mice ear

Group	Number of animals	Swelling (mg)
			Model control group	12	14.38±2.16
Positive controls	12	2.19±0.99***
			High dose group of the present invention	12	3.56±1.78**
Dosage group in the present invention	12	6.21±1.82*
			Low dose group of the present invention	12	10.15±2.52*

Compare with model control group: * p ＜ 0.05, * * p ＜ 0.01, * * * p ＜ 0.001

Test result indicate that, liniment xylol of the present invention causes mice auricle swelling obvious inhibiting effect, Its high dose group compares with model group pole significant difference.

3, the present invention observed result to anti-mouse group Ankle Joint Inflammation swelling

Table 4 medicine observed result to anti-mouse group Ankle Joint Inflammation swelling

Clinical trial:

Scapulohumeral periarthritis Chinese medicine has the multiple titles such as scapulohumeral periarthritis, scapulohumeral periarthritis, congealed shoulder, bursitis of shoulder, is a kind of Shoulder joint and the degeneration of surrounding soft tissue and aseptic inflammation.This disease onset is slow, and the course of disease is longer, Considerable distress is brought to patient.The Therapeutic Method being presently available for primary disease has a lot, as massage, acupuncture, The method such as physical therapy and nerve block, effect differs.The author uses external application of Chinese medicine importing and rehabilitation maneuver to combine Closing treatment primary disease 50 example, effect is notable.Now it is reported as follows.

1 data and method

1.1 physical data: this organizes 50 examples, or live from JIUYUE, 2010 to these Out-patient Departments of in JIUYUE, 2012 The patient of institute.The maleest 26 examples, female 24 example；Age 28～58 years old, average 46.1 years old；The course of disease less than 1 year Person 16 example, 1～2 year person 2 example, more than 2 years person 20 examples；Right shoulder 21 example, left shoulder 17 example, both shoulders 16 example. All meet the 2nd diagnostic criteria that scapulohumeral periarthritis academic discuss can determine whether in the whole nation in 1991.Wherein 9 examples have shoulder Portion's trauma history, 25 examples have wind and cold humidity to suffer from cold medical history, and 3 examples have the unilateral upper limb history of excessively application, and remaining is sick Example is without clear and definite inducement.The symptom of patient includes shoulder pain and dysfunction, receipts in shoulder joint, abduction, Dorsiflexion and spinfunction are the most limited.Rejecting standard: 1. CT and or MRI check be found to have cervical vertebra and (or) The evidence of shoulder joint bone diseases.2. concurrent liver, kidney or blood system serious disease.3. concurrent whole body Infectious

Disease.4. there are medicine and alcohol intolerance history.

1.2 Therapeutic Method: be described below.

Chinese medicine wet-hot compress the most of the present invention leads people: takes Herba Epimedii 15g, Cortex Eucommiae 13g, Radix Morindae Officinalis 13g, mends Bone fat 13g, Radix Linderae 13g, Radix Salviae Miltiorrhizae 12g, Rhizoma Corydalis 12g, geranium 11g, Caulis Spatholobi 11g, Radix Angelicae Dahuricae 13g, Herba Asari 13g, Olibanum (processed) 12g, Myrrha 13g, Radix Clematidis 12g, Radix Dipsaci 13g, Cortex Acanthopancis 12g, Herba Sarcandrae 11g, Caulis Trachelospermi 14g, Pheretima 12g, Eupolyphaga Seu Steleophaga 11g, Rhizoma Drynariae 13g, Herba speranskiae tuberculatae 12g, by the present invention Described in embodiment, method is prepared as liniment, uses damp and hot physical therapy apparatus (LGT-1000 Ao Nuokang medical treatment section Skill company limited), the liner dipping in Chinese medicinal liniment is placed in inside shoulder joint and outside, adapts to according to patient Capacity adjustment temperature, controlling maximum temperature during treatment is 45 DEG C, 20 minutes each treatment times.

1.2.2 contrast groups.Commercially available Ma Yinglong Moschus dispel pain liniment, the quasi-word of traditional Chinese medicines: Z20043814, external, Smear affected part, use damp and hot physical therapy apparatus (LGT-1000 Ao Nuokang medical science and technology company limited), will The liner dipping in Chinese medicinal liniment is placed in inside shoulder joint and outside, adapts to capacity adjustment temperature according to patient, Controlling maximum temperature during treatment is 45 DEG C, 20 minutes each treatment times.

2 results

2.1 evaluation methodologys: use own control research method, respectively at treatment before and complete 1 treatment Efficacy evaluation is carried out after journey treatment.With reference to " rehabilitation medicine evaluation handbook " standard rating comprehensive therapeutic effect.① 1 clinical cure: shoulder without pain, in shoulder joint lift scope up to 180 degree, inside and outside rotation up to 90 degree, After when stretching inward turning, thumb is up to T spinous process level, and function returns to one's perfect health；The most effective: to carry out weight muscle power labor Mild pain after dynamic or strenuous exercise, when shoulder joint is lifted, 120 degree of ＜ range of activity ＜ 150 degree, inside and outside During rotation, 30 degree of ＜ range of activity ＜ 60 degree, after when stretching inward turning, thumb is up to L spinous process level, functional rehabilitation 80%～90；The most effective: moderate or sustainable pain, increase the weight of once in a while night, shoulder joint is lifted Time, 90 degree of ＜ range of activity ＜ 120 degree, during inside and outside rotation, 20 degree ＜ range of activity ＜ 60 degree, after stretch interior During rotation, thumb is up to L.Spinous process level, function is obviously improved, and can be engaged in part physical exertion, life Basic self-care；The most invalid: patient's severe pain, sleep can be affected, when shoulder joint is lifted, range of activity ＜ 90 degree, during inside and outside rotation, range of activity ＜ 20 degree, function is slightly improved, but comb one's hair, the action such as rubdown Limited.With reference to U.S.'s Michael Reese medical centre standard rating shoulder pain and shoulder mobility scope. Wherein shoulder is 75 points without pain, occasionally has mild pain 60～74 points, mild pain 45～59 points, moderate Pain 30～44 points, have an intense pain 0～29 point.Shoulder mobility function include anteflexion, after stretch, abduction, Interior receipts, outward turning and 6 orientation of inward turning, total score is 25 points.

2.2 statistical procedures: use 13.0 editions statistical packages of SPSS to carry out data analysis, metering Data represents with mean ± standard deviation (z ± s), uses self pair f inspection, and P ＜ 0.05 represents that difference has Statistically significant.

2.3 results: 50 example patients all complete treatment and the efficacy evaluation of 30 days, because of untoward reaction The person of dropping by the wayside.Comprehensive therapeutic effect evaluation result shows: after 1 course of therapy, and treatment group 25 example is suffered from Person, clinical cure 13 example, effective 9 examples, effective 2 examples, invalid 1 example, total effective rate is 96%.Matched group 25 examples, clinical cure 10 example, effective 6 examples, effective 3 examples, invalid 6 examples, total effective rate is 76%.

Treatment group Michael Reese evaluation result shows: shoulder pain scoring from treatment before 23.78 ± 11.01 points of 54.82 ± 8.82 points (t=59.76, P ＜ 0.01) increased to after treatment.Shoulder joint is lived Dynamic function is obviously improved before relatively treating, anteflexion, after stretch, abduction, interior receipts, outward turning and inward turning mobility relatively Compare difference the most statistically significant (being P ＜ 0.01) before treatment, refer to table 1.Adverse reaction monitoring is tied Fruit display: have 6 example patients skin of shoulder in time treating 8～12 times and a small amount of brown maculopapule occurs, slightly Pruritus, gradually disappears after stopping treatment.Have no other untoward reaction.

Before and after the treatment of table 1 treatment group, range of motion compares (X ± S)

Note: compare with before treatment, * P ＜ 0.01.

3 discuss

Chinese medicine is thought, the diseased region of primary disease at shoulder through normal pulse muscles along the regular meridians, the people of fifty-year-old, healthy energy is not Foot, seeks Wei Jianxu, if local experiences wind and cold, or tired sprain and contusion, or be accustomed to inclined side and crouch, muscle arteries and veins is subject to Oppression, then causes QI and blood retardance and forms shoulder numbness.With the passing of time, locally QI-blood circulation is not smooth, the QI and blood stasis of blood for shoulder pain Stagnant, so that affected part swelling adhesion, final joint stiffness, shoulder arm can not movement.Non-drug therapy quilt at present Being widely used in the treatment of scapulohumeral periarthritis, compare with Drug therapy and operative therapy, non-drug therapy is in shoulder Scorching treatment is upper with the obvious advantage.It is based on the pathomechanism of patient's inflammatory pain and joint movement disorder, I Apply Chinese medicine wet-hot compress import and rehabilitation maneuver Comprehensive Treatment, hence it is evident that improve scapulohumeral periarthritis treatment effect Really.

Concrete case:

Wang, man, 34 years old, first visit on January 20 in 2012.Main suit: two shoulder pains are more than 1 year, time light Shi Chong.Can not wind-engaging, often oneself cup, be the congestion of black purple entirely.Readme two shoulders of sleep like dew Outside quilt.Check: outside shoulder, there are obvious pressure pain point, upper act, interior receipts, abduction, outward turning in center The most limited, but right range of motion is anteflexion raises 100 degree, and abduction lifts 90 degree, and interior receipts are helped to shoulder heavy thing tired Difficulty, after stretch inward turning right finesse joint at the 5th spinous process of lumbar vertebra, two-arm is flat lifts the obvious projection of right acromion and pain Bitterly.X line is taken the photograph sheet and is shown: have no bone lesion.It is diagnosed as scapulohumeral periarthritis, dialectical stagnant for the deficiency of vital energy cold coagulation stasis of blood.Control Treat: prescription Herba Epimedii 15g, Cortex Eucommiae 13g, Radix Morindae Officinalis 13g, Fructus Psoraleae 13g, Radix Linderae 13g, Radix Salviae Miltiorrhizae 12g, Rhizoma Corydalis 12g, geranium 11g, Caulis Spatholobi 11g, Radix Angelicae Dahuricae 13g, Herba Asari 13g, Olibanum (processed) 12g, Myrrha 13g, Radix Clematidis 12g, Radix Dipsaci 13g, Cortex Acanthopancis 12g, Herba Sarcandrae 11g, Caulis Trachelospermi 14g, Pheretima 12g, Eupolyphaga Seu Steleophaga 11g, Rhizoma Drynariae 13g, Herba speranskiae tuberculatae 12g, as described in the embodiment of the present invention, method is prepared as liniment, Use damp and hot physical therapy apparatus (LGT-1000 Ao Nuokang medical science and technology company limited), Chinese medicine will be dipped in and put on the skin The liner of agent is placed in inside shoulder joint and outside, adapts to capacity adjustment temperature according to patient, controls during treatment Maximum temperature is 45 DEG C, 20 minutes each treatment times, 30 days altogether.Further consultation on February 25, pain base This alleviation, for anti-recurrence, it is desirable to continue with 1 course for the treatment of.Readme adheres to that arm is taken exercise, and climbs wall and takes exercise, sleeps Feel that building shoulder prevents suffering from cold.After 1 year, patient examines, and askes and knows that former scapulohumeral periarthritis heals, has no recurrence.

Claims

1. the Chinese medicine for external application of a cure scapulohumeral periarthritis, it is characterised in that described external preparation by with The crude drug of lower weight portion is made: Herba Epimedii 10～20 parts, the Cortex Eucommiae 10～20 parts, Radix Morindae Officinalis 10～20 parts, Fructus Psoraleae 10～20 parts, the Radix Linderae 10～20 parts, Radix Salviae Miltiorrhizae 10～20 parts, Rhizoma Corydalis 10～20 parts, geranium 10～20 parts, Caulis Spatholobi 10～20 parts, the Radix Angelicae Dahuricae 10～20 parts, Herba Asari 10～20 parts, Olibanum (processed) 10～20 Part, Myrrha 10～20 parts, Radix Clematidis 10～20 parts, Radix Dipsaci 10～20 parts, Cortex Acanthopancis 10～20 parts, swollen Joint wind 10～20 parts, Caulis Trachelospermi 10～20 parts, Pheretima 10～20 parts, Eupolyphaga Seu Steleophaga 10～20 parts, Rhizoma Drynariae 10～20 parts, Herba speranskiae tuberculatae 10～20 parts.

The Chinese medicine for external application of cure scapulohumeral periarthritis the most according to claim 1, it is characterised in that described External preparation is made up of the crude drug of following weight portion: Herba Epimedii 10～15 parts, the Cortex Eucommiae 10～15 parts, bar Halberd sky 10～15 parts, Fructus Psoraleae 10～15 parts, the Radix Linderae 10～15 parts, Radix Salviae Miltiorrhizae 10～15 parts, Rhizoma Corydalis 10～ 15 parts, geranium 10～15 parts, Caulis Spatholobi 10～15 parts, the Radix Angelicae Dahuricae 10～15 parts, Herba Asari 10～15 parts, Olibanum (processed) 10～20 parts, Myrrha 10～20 parts, Radix Clematidis 10～20 parts, Radix Dipsaci 10～20 parts, Cortex Acanthopancis 10～20 parts, Herba Sarcandrae 10～20 parts, Caulis Trachelospermi 10～20 parts, Pheretima 10～20 parts, Eupolyphaga Seu Steleophaga 10～ 20 parts, Rhizoma Drynariae 10～20 parts, Herba speranskiae tuberculatae 10～20 parts.

The Chinese medicine for external application of cure scapulohumeral periarthritis the most according to claim 1, it is characterised in that described External preparation is made up of the crude drug of following weight portion: Herba Epimedii 10～20 parts, the Cortex Eucommiae 10～20 parts, bar Halberd sky 10～20 parts, Fructus Psoraleae 10～20 parts, the Radix Linderae 10～20 parts, Radix Salviae Miltiorrhizae 10～20 parts, Rhizoma Corydalis 10～ 20 parts, geranium 10～20 parts, Caulis Spatholobi 10～20 parts, the Radix Angelicae Dahuricae 10～20 parts, Herba Asari 10～20 parts, Olibanum (processed) 10～15 parts, Myrrha 10～15 parts, Radix Clematidis 10～15 parts, Radix Dipsaci 10～15 parts, Cortex Acanthopancis 10～15 parts, Herba Sarcandrae 10～15 parts, Caulis Trachelospermi 10～15 parts, Pheretima 10～15 parts, Eupolyphaga Seu Steleophaga 10～ 15 parts, Rhizoma Drynariae 10～15 parts, Herba speranskiae tuberculatae 10～15 parts.

4. the system of the Chinese medicine for external application of a cure scapulohumeral periarthritis as according to any one of claims 1 to 3 Preparation Method, it is characterised in that the dosage form of described external preparation is liniment, and its preparation method includes:

Preparation method the most according to claim 4, it is characterised in that in described step a, by crow Medicine, the Radix Angelicae Dahuricae, Herba Asari, Olibanum (processed) and the distillation of the Myrrha way of distillation are vaporized into white crystals, and pulverizer is pulverized Rear mistake 120 mesh dusting cover, fine powder is standby.

Preparation method the most according to claim 4, it is characterised in that in described step b, by it Heating and refluxing extraction 2 times in ethanol put into by remaining raw material, each 1～2 hour, merged by 2 extracting solution and stand, Go supernatant, united extraction liquid, then the ultrafiltration post ultrafiltration that molecular weight is 5000-10000 through damming, ultrafiltration The extractum of 1.36 when liquid concentrating under reduced pressure relative density is 80 DEG C, heating is concentrated into paste, stand for standby use, becomes For component 1.

Preparation method the most according to claim 4, it is characterised in that in described step c, by upper State the medicinal residues that ethanol extraction crosses and add 10 times amount water heating and refluxing extraction 2 times, each 1～2 hour, 2 times are carried Take liquid to merge and stand, remove supernatant, united extraction liquid, then through the molecular weight that dams be the super of 5000-10000 Filter post ultrafiltration, the extractum of 1.36 when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C, heating is concentrated into paste, Stand for standby use, becomes component 2.

Preparation method the most according to claim 4, it is characterised in that in described step d, by upper State component 1 2-in-1 also with component, insert after decompression recycling ethanol in economic benefits and social benefits vacuum concentrator, be concentrated into 90 DEG C Time relative density be the extractum of 1.05, be concentrated into every 1ml crude drug amount Han 1g, then add what above-mentioned steps obtained Crystalline powder, is dissolved in ethanol one-tenth liniment after stirring.

9. the system of the Chinese medicine for external application of a cure scapulohumeral periarthritis as according to any one of claims 1 to 3 Preparation Method, it is characterised in that described external preparation dosage form is unguentum, its preparation process is: by Herba Asari, Olibanum (processed), Myrrha, Radix Clematidis and the distillation of the Radix Linderae way of distillation are vaporized into white crystals, after pulverizer is pulverized Crossing 120 mesh dusting covers, fine powder is standby；The most remaining raw medicinal material adds soak with ethanol 12 hours, and heating is boiled 30～40 minutes, filtering, filtrate is standby；Filtering residue adds ethanol second time heating, boils 30～40 minutes, Filtering, filtrate is standby；Filtering residue adds water, for the third time heated and boiled 40～50 minutes, filters；Merge three Secondary extracting solution, is concentrated into the concentrated solution that relative density is 1.08；Filter, stand 24 hours, after go Clear liquid, obtains cream drug；The white crystalline powder arrived above-mentioned steps distilled puts into paste, mixes all Intellectual circle stirs, tinning after sterilizing.

10., according to the Chinese medicine for external application of cure scapulohumeral periarthritis according to any one of claims 1 to 3, it is special Levying and be, described external drug dosage forms is: spray, ointment, tincture, unguentum, patch, traditional Chinese medicine fumigating Steam agent or Local out dressing gauze agent.