CN104287699A - Device for monitoring pulse waveform and measuring blood pressure simultaneously - Google Patents
Device for monitoring pulse waveform and measuring blood pressure simultaneously Download PDFInfo
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- CN104287699A CN104287699A CN201410487572.7A CN201410487572A CN104287699A CN 104287699 A CN104287699 A CN 104287699A CN 201410487572 A CN201410487572 A CN 201410487572A CN 104287699 A CN104287699 A CN 104287699A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/021—Measuring pressure in heart or blood vessels
- A61B5/02108—Measuring pressure in heart or blood vessels from analysis of pulse wave characteristics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/021—Measuring pressure in heart or blood vessels
- A61B5/02141—Details of apparatus construction, e.g. pump units or housings therefor, cuff pressurising systems, arrangements of fluid conduits or circuits
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/021—Measuring pressure in heart or blood vessels
- A61B5/022—Measuring pressure in heart or blood vessels by applying pressure to close blood vessels, e.g. against the skin; Ophthalmodynamometers
- A61B5/0225—Measuring pressure in heart or blood vessels by applying pressure to close blood vessels, e.g. against the skin; Ophthalmodynamometers the pressure being controlled by electric signals, e.g. derived from Korotkoff sounds
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
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- Physics & Mathematics (AREA)
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- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
Abstract
The invention discloses a device for monitoring pulse waveform and measuring blood pressure simultaneously, and belongs to the technical field of medical equipment. A pulse wave module detects brachial arterial pulse fluctuations through a pressure sensor, and signals are transmitted to an analog signal conditioning circuit, an A/D conversion circuit, a single chip microcomputer, an accessory circuit of the single chip microcomputer and an interface circuit between the single chip microcomputer and a PC. Collected data are transmitted to the computer through signals. Meanwhile, blood pressure is measured through inflation and deflation of an inflatable oversleeve, and the data are transmitted to the computer. Finally, the computer collects the pulse waveforms of the pulse wave module, and meanwhile the waveform sampling frequency, the amplification factor and the base line position are adjusted during sampling setting, high pressure, low pressure and the heart rate of a voltage module are received, and the real-time detection function is achieved. According to the device, the obtained pulse waveform data and blood pressure value lay the foundation of calculation of the average blood flow volume, the cardiac output and the like and finally achievement of early prediction of some hemodynamic diseases and the clinical diagnostic function.
Description
Technical field
The invention belongs to the verification experimental verification field of medical treatment device, relate to a kind of signal processing apparatus, particularly a kind of device of simultaneously monitoring pulse waveform and blood pressure measurement.
Background technology
Cardiovascular disease (Cardiovascular disease, CVD) be the important diseases that current developed country mortality rate holds pride of place, also be the class disease that mortality rate is the highest in China, World Health Organization (WHO) has been classified as the number one killer of 21 century harm humans health, and it has become the major public health problem in China and the world.The serious Health and Living quality affecting people, therefore, to early prediction and the diagnoses and treatment in mid-term of cardiovascular disease, has and important meaning.
Arterial pulse wave is produced by the periodic contractile of heart and diastole, and therefore pulse wave is one natural " information source ".There are some researches show, cardiovascular blood flow parameter can be reflected by pulse wave, and the pulse wave of normal person and anon-normal ordinary person may have different display forms.Theoretically, if the propagation characteristic of pulse wave and the relation of blood flow rule can be worked out qualitative or quantitatively, just human body cardio-vascular parameters can be diagnosed by measuring pulse wave.Therefore according to this situation, we just can according to the different manifestations of pulse wave, and diagnosis early goes out the potential deterrent of cardiovascular disease, for prevention and early treatment's cardiovascular disease strive for the quality time.But existing pulse wave analysis system major part belongs to professional medical equipment, needs professional person to operate, and expensive, be not easy to mobile, thus limit its general usability.So research one is easy to operation, pulse analyzer that is convenient mobile and that have a wireless data transmission function has very large theory and practical value.This instrumentation is simple, low cost, nothing are dangerous, nothing is avoided, intelligence degree is high, even if the common personage face of staying at home can oneself operate, does not need the help of health care professional completely.In the research of this non-invasive detector, the analysis of pulse signal and the detect delay of blood pressure are crucial.
Summary of the invention
The object of this invention is to provide one and monitor pulse waveform and blood pressure measuring device simultaneously.Concrete technical scheme is as follows:
A kind of device of simultaneously monitoring pulse waveform and blood pressure measurement, comprise the interface circuit of the Wave data acquisition module of pulse wave, analog signal conditioner circuit, A/D change-over circuit, single-chip microcomputer C8051F330 and accessory circuit, CP2102, the signal in interface circuit is transferred to computer by USB interface; Blood pressure module controls cuff inflation by micro air pump, electromagnetic gas valve controls cuff deflation, the signal that pressure transducer collects is transferred to differential amplifier circuit, high pass filter, amplifier, low pass filter successively, then pass to single-chip microcomputer C8051F330 treatment circuit and carry out the diastolic pressure of oscillographic method and the calculating of systolic pressure, and be transferred to computer by the USB interface of CP2012 interface circuit; The last collection completing data on computers, receive the numerical value of the systolic pressure of the numerical value of each point in the waveform of pulse wave module and blood pressure module, diastolic pressure and pulse frequency, carry out the display of pulse waveform and high pressure, low pressure and pulse frequency, regulate sample frequency, amplification, the baseline position of pulse waveform, in measuring process, show monitoring information in real time.
Pulse wave sensor is placed on human body brachial artery position, adopts HK2000C sensor, and this sensor adopts force sensing element PVDF piezoelectric film.
In the signal that pressure transducer spreads out of, adopt three amplifier instrument amplifier circuit to change signal amplitude, obtain differential wave, improve signal amplitude, for single-chip microcomputer to the data analysis collected and research.
Gathered data store by single-chip microcomputer C8051F330, adopt a string control word to encapsulate, make collected pulse wave and blood pressure data by communication protocol by computer to access.
Complete the acquisition and processing of data on computers, to make on computer display pulse waveform, high pressure, low pressure, pulse frequency simultaneously, and carry out regulating the measurement of the sample frequency of pulse waveform, amplification, baseline position.
Beneficial effect:
The pulse wave module of hardware module provided by the invention and blood pressure module are by the triggering of computer software, carry out the collection of data, can be transferred on computer by the transmission of USB, and by the collection of computer to data, the waveform of integrative display pulse wave, and the adjustment that sample frequency, amplification, baseline position can be carried out pulse waveform; Real-Time Monitoring can be carried out to force value in cuff in cuff inflation deflation course in addition, when venting completes, the numerical value of the systolic pressure of human body, diastolic pressure, pulse frequency can be gathered, and can system report an error when operation mistake.
Accompanying drawing explanation
Fig. 1 blood pressure pulse measuring system block diagram
Fig. 2 pulse wave measurement system block diagram
Fig. 3 voltage lifting circuit
Fig. 4 second-order low-pass filter circuit
Figure 55 V changes-5V circuit
Figure 65 V changes 3.3V circuit
Fig. 7 pulse wave module Single Chip Microcomputer (SCM) program flow chart
Fig. 8 CP2102 interface circuit
Fig. 9 blood pressure measuring system block diagram
Figure 10 is based on the stable reference voltage source of TL431
Figure 11 tri-amplifier instrument amplifier circuit
Figure 12 low-pass filter circuit
Figure 13 pulse wave signal circuit of high pass filter
Figure 14 pulse wave signal low-pass filter circuit
Figure 15 pulse wave signal amplifying circuit
Figure 16 blood pressure module Single Chip Microcomputer (SCM) program flow chart
The INTERFACE DESIGN of Figure 17 integrated pulse ripple and blood pressure display
Detailed description of the invention
Mainly comprise in pulse wave module acquires system: the interface circuit of pulse wave sensor, analog signal conditioner circuit (i.e. voltage lifting circuit and filter circuit), A/D change-over circuit, single-chip microcomputer C8051F330 circuit and CP2102, is finally transferred to computer disposal (as Fig. 2).
What this part of pulse wave sensor adopted is that pulse wave sensor adopts HK2000C sensor, and this sensor adopts force sensing element (PVDF piezoelectric film), is a kind of soft contact hurtless measure pulse transducer.Relative to piezoelectric ceramics or other more traditional materials, the piezoelectric constant of novel piezoelectric material PVDF and piezoelectric strain constant and piezoelectric stress constant all higher, the bio-signal acquisition this and faint for pulse wave is relatively difficult, and sensitivity and accuracy are all higher.What this sensor exported is analog voltage signal, needs to be further processed.
The scope of pulse transducer outputting analog signal voltage is-0.5 ~+1.5V, has negative value, so do baseline adjustment with in-phase amplification circuit, realize voltage lifting (as Fig. 3) owing to exporting.The present invention selects OP07 operational amplifier, and OP07 is the accurate amplifier integrated circuit of high-precision and low-offset voltage.OP07 has the features such as extremely low input offset voltage, the drift of extremely low offset voltage temperature, very low input noise and voltage amplitude long-term stability, and zeroing and frequency issues just can meet the demands to use OP07 amplifier generally need not consider.Can obtain as calculated, Vout=1.5+Vin, wherein Vin is pulse transducer output signal, i.e. the input signal of OP07, Vout is the output signal of OP07.
The pulse signal frequency exported through pulse wave sensor is very low, is easy to introduce interference, and these interference have the Hz noise coming from 50Hz, also has the illusion interfering signal etc. that some bring from human body shake and psychentonia.The method processing these interference has the methods such as hardware filtering, scm software filtering and PC software filtering, the present invention tentatively adopts hardware second-order low-pass filter circuit (as Fig. 4) to realize, because the highest frequency of pulse signal is no more than 40Hz, so the cut-off frequency of low-pass filtering is set to 40Hz.
System adopts outside employing 5V Power supply, because internal system also needs-5V and 3.3V voltage, so the high and voltage conversion chip MAX735 of good stability of system selection integrated level respectively realizes the conversion (as Fig. 5) of+5V to-5V, for 3.3V voltage, need+5V voltage transitions to become 3.3V, realize this function (as Fig. 6) by AS1117-3.3.
The A/D conversion portion of pulse wave module and having been come by single-chip microcomputer (C8051F330) module with the communications portion of PC, mainly comprises initialization and major cycle.After the I/O mouth to single-chip microcomputer, external clock, A/D conversion and serial ports initialize respectively, single-chip microcomputer can be in waits for serial port command state.As the hexadecimal number received (such as 20h, xxh) during instruction, before pulse wave signal is gathered, first hardware circuit duty is detected, if fault-free, then open the collection that pulse wave signal is carried out in A/D conversion, while image data, the functions (as Fig. 7) such as the calculating of amplitude baseline, gain baseline adjusted and heart rate calculating can be carried out.The signal that single-chip microcomputer exports is transferred on computer by the interface circuit (as Fig. 8) of CP2102, gathers for computer software.
In blood pressure module system, constituted the main body (as Fig. 9) of blood pressure measurement module by upper arm-type aerating gasbag, micro air pump, drive circuit, constant-current source circuit, signal conditioning circuit, pressure transducer and single chip circuit etc., wherein difference amplifier, high pass filter, amplifying circuit and low pass filter are the elements of circuit for signal conditioning.
Pressure transducer mainly carrys out alternative pressure-sensitive mode with strain resistor, and its full-bridge type Wheatstone bridge is made up of 4 strain resistors, and the output of its voltage is main or realize by straining, and voltage changes accordingly along with the change of strain resistor.This electric bridge mainly adopts constant voltage and these two kinds of methods of constant current to carry out energy supply, in constant voltage energy-provision way, its voltage changes along with resistance sizes and changes, namely the change of resistance plays a decisive role to voltage, but the temperature change of strain resistor can disturb electric bridge, make its temperature produce deviation within the specific limits, thus cause sensor accuracy to decline.But under the state of constant current energy supply, it exports and the non-linear proportionate relationship of resistance, namely the temperature of external environment can not produce interference to electric bridge, so in order to ensure its stable and accuracy, the present invention adopts the constant current source be made up of amplifier LM324.Have the series of advantages such as high-performance, low price and stability due to TL431, the present invention selects the stable reference voltage source (as Figure 10) based on TL431, and reference voltage Vout is 3V.
In the signal that sensor spreads out of, rising and the enlarge leadingly of its amplitude to blood pressure signal of blood pressure signal to noise ratio play decisive role, this is because the signal collected from pressure transducer is very weak, be difficult to provide and analyze and research, want to allow monolithic function to the data analysis collected and research, just its amplitude must be brought up to certain value, the present invention adopts three amplifier instrument amplifier circuit (as Figure 11) to change signal amplitude.This module carries out the measurement of blood pressure, needs to isolate oversleeve static pressure signal and pulse wave signal, so will design corresponding filter circuit respectively from pressure transducer output signal.In deflation course, in cuff, pressure is slowly change, so oversleeve static pressure signal belongs to low frequency signal, need adopt low-pass filter circuit (as Figure 12) the filtering high-frequency signal of LM324.
The pressure signal that sensor exports comprises cuff pressure signal and pulse wave signal, they are not simple superpositions, wherein also to be mingled with from the High-frequency Interference in the external world, direct current or low frequency component, namely pressure signal not only comprises High-frequency Interference but also comprise low-frequency disturbance, only has a wherein band frequency signal to be that we need.The frequency range of pulse wave signal is 0.6-39Hz, therefore, devise the pulse wave signal low-pass filter circuit (as Figure 14) that pulse wave signal circuit of high pass filter (as Figure 13) that cut-off frequency is 0.6Hz and cut-off frequency are 39Hz, extract pulse wave signal.
Pressure signal through band-pass filter just can be called pulse wave signal, but pulse wave signal amplitude is less, the present invention devises the adjustable amplifying circuit (as Figure 15) that a maximum amplification is 200 times for this reason, the pulse wave signal recorded is adjusted to the amplitude 0-3.3V that C8051F330 single-chip microcomputer requires.
The A/D conversion portion of blood pressure module and having been come (as Figure 16) by single-chip microcomputer (C8051F330) module with the communication part of PC, at the I/O mouth to single-chip microcomputer, external clock, after A/D conversion and serial ports initialize respectively, single-chip microcomputer is in waits for serial port command state.When receiving hexadecimal number (such as 0XFF) instruction, before blood pressure signal is gathered, first hardware circuit duty being detected, if fault-free, opening the collection that blood pressure data is carried out in A/D conversion.The signal that single-chip microcomputer exports is transferred on computer by the interface circuit of CP2102, gathers for computer software.
In computer software design, adopt VC++6.0 software API code to carry out the INTERFACE DESIGN (as Figure 17) of MFC and the transmission of order, this software is the display of a collection pulse waveform designed based on VC++6.0, blood pressure values.For measure human pulse waveform and blood pressure values and display on computers and process.
In interface analysis, consider to come design configuration interface based on man-machine interaction, comprise waveform viewing area, equipment operating district, information district, sampling setting area.This interface can display of blood pressure module serial port setting, blood pressure module operation of serial-port, blood pressure display, pulse wave module serial port setting, pulse wave module operation of serial-port, pulse waveform setting operation, pulse wave sample waveform, monitoring information show in real time.
In serial port function, by opening of basic API codes implement serial ports, close, the configuration of fixing read-write mode and serial ports; In communication process, control the input of serial ports, output so that data can be obtained as required the data collected is carried out processing and showing as required by some control words.
Claims (5)
1. monitor the device of pulse waveform and blood pressure measurement for one kind simultaneously, comprise the interface circuit of the Wave data acquisition module of pulse wave, analog signal conditioner circuit, A/D change-over circuit, single-chip microcomputer C8051F330 and accessory circuit, CP2102, the signal in interface circuit is transferred to computer by USB interface; Blood pressure module controls cuff inflation by micro air pump, electromagnetic gas valve controls cuff deflation, the signal that pressure transducer collects is transferred to differential amplifier circuit, high pass filter, amplifier, low pass filter successively, then pass to single-chip microcomputer C8051F330 treatment circuit and carry out the diastolic pressure of oscillographic method and the calculating of systolic pressure, and be transferred to computer by the USB interface of CP2012 interface circuit; The last collection completing data on computers, receive the numerical value of the systolic pressure of the numerical value of each point in the waveform of pulse wave module and blood pressure module, diastolic pressure and pulse frequency, carry out the display of pulse waveform and high pressure, low pressure and pulse frequency, regulate sample frequency, amplification, the baseline position of pulse waveform, in measuring process, show monitoring information in real time.
2. device of simultaneously monitoring pulse waveform and blood pressure measurement as claimed in claim 1, is characterized in that: pulse wave sensor is placed on human body brachial artery position, adopts HK2000C sensor, and this sensor adopts force sensing element PVDF piezoelectric film.
3. device of simultaneously monitoring pulse waveform and blood pressure measurement as claimed in claim 1, it is characterized in that: in the signal that pressure transducer spreads out of, adopt three amplifier instrument amplifier circuit to change signal amplitude, obtain differential wave, improve signal amplitude, for single-chip microcomputer to the data analysis collected and research.
4. device of simultaneously monitoring pulse waveform and blood pressure measurement as claimed in claim 1, it is characterized in that: gathered data store by single-chip microcomputer C8051F330, adopt a string control word to encapsulate, make collected pulse wave and blood pressure data by communication protocol by computer to access.
5. device of simultaneously monitoring pulse waveform and blood pressure measurement as claimed in claim 1, it is characterized in that: the acquisition and processing completing data on computers, to make on computer display pulse waveform, high pressure, low pressure, pulse frequency simultaneously, and carry out regulating the measurement of the sample frequency of pulse waveform, amplification, baseline position.
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Cited By (6)
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| CN105596001A (en) * | 2015-12-13 | 2016-05-25 | 北京工业大学 | Device with automatic gear regulation function and temperature and bioimpedance simultaneous measurement function |
| CN106175734A (en) * | 2016-07-14 | 2016-12-07 | 苏州咖丢卫私康信息科技有限公司 | A kind of circuit extracting blood pressure cuff Sasser and blood pressure cuff measuring instrument |
| CN106955091A (en) * | 2017-03-22 | 2017-07-18 | 上海轶龙应用软件开发有限公司 | A kind of intelligent object wearing device of measurable pulse wave |
| CN109044312A (en) * | 2018-08-30 | 2018-12-21 | 东南大学 | A kind of electronic sphygmomanometer and its blood pressure measuring method based on Korotkoff's Sound |
| CN110461224A (en) * | 2016-12-15 | 2019-11-15 | 薇心健康有限公司 | Wearable pulse wave measuring system and method |
| CN111166298A (en) * | 2020-01-15 | 2020-05-19 | 天津科技大学 | Household diagnosis and treatment expert system based on artificial intelligence |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105596001A (en) * | 2015-12-13 | 2016-05-25 | 北京工业大学 | Device with automatic gear regulation function and temperature and bioimpedance simultaneous measurement function |
| CN106175734A (en) * | 2016-07-14 | 2016-12-07 | 苏州咖丢卫私康信息科技有限公司 | A kind of circuit extracting blood pressure cuff Sasser and blood pressure cuff measuring instrument |
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| CN106955091B (en) * | 2017-03-22 | 2023-09-19 | 上海轶龙应用软件开发有限公司 | Intelligent wearing device capable of measuring pulse wave |
| CN109044312A (en) * | 2018-08-30 | 2018-12-21 | 东南大学 | A kind of electronic sphygmomanometer and its blood pressure measuring method based on Korotkoff's Sound |
| CN111166298A (en) * | 2020-01-15 | 2020-05-19 | 天津科技大学 | Household diagnosis and treatment expert system based on artificial intelligence |
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Application publication date: 20150121 |