CN104273132B - A kind of efficient bactericidal composite containing Hexanaphthene flusulfamide - Google Patents
A kind of efficient bactericidal composite containing Hexanaphthene flusulfamide Download PDFInfo
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- CN104273132B CN104273132B CN201410482375.6A CN201410482375A CN104273132B CN 104273132 B CN104273132 B CN 104273132B CN 201410482375 A CN201410482375 A CN 201410482375A CN 104273132 B CN104273132 B CN 104273132B
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- hexanaphthene flusulfamide
- active component
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- flusulfamide
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- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 title claims abstract description 99
- GNVDAZSPJWCIQZ-UHFFFAOYSA-N flusulfamide Chemical compound ClC1=CC([N+](=O)[O-])=CC=C1NS(=O)(=O)C1=CC=C(Cl)C(C(F)(F)F)=C1 GNVDAZSPJWCIQZ-UHFFFAOYSA-N 0.000 title claims abstract description 99
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 18
- 239000002131 composite material Substances 0.000 title claims abstract description 13
- 239000000203 mixture Substances 0.000 claims abstract description 40
- 201000010099 disease Diseases 0.000 claims abstract description 39
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 39
- 239000005787 Flutriafol Substances 0.000 claims abstract description 18
- JWUCHKBSVLQQCO-UHFFFAOYSA-N 1-(2-fluorophenyl)-1-(4-fluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanol Chemical compound C=1C=C(F)C=CC=1C(C=1C(=CC=CC=1)F)(O)CN1C=NC=N1 JWUCHKBSVLQQCO-UHFFFAOYSA-N 0.000 claims abstract description 17
- 239000000375 suspending agent Substances 0.000 claims description 19
- 235000007164 Oryza sativa Nutrition 0.000 claims description 16
- 235000009566 rice Nutrition 0.000 claims description 16
- -1 glume blight Inorganic materials 0.000 claims description 15
- 239000000839 emulsion Substances 0.000 claims description 14
- 239000003094 microcapsule Substances 0.000 claims description 14
- 206010039509 Scab Diseases 0.000 claims description 13
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 claims description 13
- 241000221785 Erysiphales Species 0.000 claims description 11
- 239000003795 chemical substances by application Substances 0.000 claims description 11
- 239000000725 suspension Substances 0.000 claims description 7
- 239000004530 micro-emulsion Substances 0.000 claims description 6
- 239000004562 water dispersible granule Substances 0.000 claims description 6
- 239000004563 wettable powder Substances 0.000 claims description 6
- 241000918585 Pythium aphanidermatum Species 0.000 claims description 5
- 230000035613 defoliation Effects 0.000 claims description 5
- 241001530056 Athelia rolfsii Species 0.000 claims description 4
- 241000607479 Yersinia pestis Species 0.000 claims description 2
- 240000007594 Oryza sativa Species 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 230000002195 synergetic effect Effects 0.000 abstract description 29
- 241000894006 Bacteria Species 0.000 abstract description 17
- 230000000694 effects Effects 0.000 abstract description 17
- 239000005767 Epoxiconazole Substances 0.000 abstract description 16
- 239000005840 Tetraconazole Substances 0.000 abstract description 16
- ZMYFCFLJBGAQRS-IRXDYDNUSA-N (2R,3S)-epoxiconazole Chemical compound C1=CC(F)=CC=C1[C@@]1(CN2N=CN=C2)[C@H](C=2C(=CC=CC=2)Cl)O1 ZMYFCFLJBGAQRS-IRXDYDNUSA-N 0.000 abstract description 15
- LQDARGUHUSPFNL-UHFFFAOYSA-N 1-[2-(2,4-dichlorophenyl)-3-(1,1,2,2-tetrafluoroethoxy)propyl]1,2,4-triazole Chemical compound C=1C=C(Cl)C=C(Cl)C=1C(COC(F)(F)C(F)F)CN1C=NC=N1 LQDARGUHUSPFNL-UHFFFAOYSA-N 0.000 abstract description 15
- 150000003851 azoles Chemical class 0.000 abstract description 14
- FQKUGOMFVDPBIZ-UHFFFAOYSA-N flusilazole Chemical compound C=1C=C(F)C=CC=1[Si](C=1C=CC(F)=CC=1)(C)CN1C=NC=N1 FQKUGOMFVDPBIZ-UHFFFAOYSA-N 0.000 abstract description 14
- DQJCHOQLCLEDLL-UHFFFAOYSA-N tricyclazole Chemical compound CC1=CC=CC2=C1N1C=NN=C1S2 DQJCHOQLCLEDLL-UHFFFAOYSA-N 0.000 abstract description 14
- 150000002825 nitriles Chemical class 0.000 abstract description 13
- 150000001875 compounds Chemical class 0.000 abstract description 5
- 230000000855 fungicidal effect Effects 0.000 abstract description 2
- 238000001228 spectrum Methods 0.000 abstract description 2
- 238000005406 washing Methods 0.000 abstract 1
- 238000012360 testing method Methods 0.000 description 44
- 238000013329 compounding Methods 0.000 description 35
- 239000003814 drug Substances 0.000 description 34
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- 241000209094 Oryza Species 0.000 description 15
- 239000012071 phase Substances 0.000 description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 14
- 239000000575 pesticide Substances 0.000 description 13
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- 239000002270 dispersing agent Substances 0.000 description 11
- 239000002904 solvent Substances 0.000 description 11
- 231100000820 toxicity test Toxicity 0.000 description 10
- 230000002528 anti-freeze Effects 0.000 description 9
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- 240000002791 Brassica napus Species 0.000 description 5
- 235000006008 Brassica napus var napus Nutrition 0.000 description 5
- 206010011732 Cyst Diseases 0.000 description 5
- 241000221662 Sclerotinia Species 0.000 description 5
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- 229920002521 macromolecule Polymers 0.000 description 5
- 235000016068 Berberis vulgaris Nutrition 0.000 description 4
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- 235000007688 Lycopersicon esculentum Nutrition 0.000 description 4
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- HZJKXKUJVSEEFU-UHFFFAOYSA-N 2-(4-chlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)hexanenitrile Chemical compound C=1C=C(Cl)C=CC=1C(CCCC)(C#N)CN1C=NC=N1 HZJKXKUJVSEEFU-UHFFFAOYSA-N 0.000 description 3
- 241000223600 Alternaria Species 0.000 description 3
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- 235000021307 Triticum Nutrition 0.000 description 3
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- FJJCIZWZNKZHII-UHFFFAOYSA-N [4,6-bis(cyanoamino)-1,3,5-triazin-2-yl]cyanamide Chemical compound N#CNC1=NC(NC#N)=NC(NC#N)=N1 FJJCIZWZNKZHII-UHFFFAOYSA-N 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 238000012271 agricultural production Methods 0.000 description 1
- 230000010165 autogamy Effects 0.000 description 1
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- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a kind of efficient bactericidal composite containing Hexanaphthene flusulfamide, bactericidal composition containing active components A Yu active component B, active components A is selected from Hexanaphthene flusulfamide, active component B is selected from any one compound following: Flusilazole, epoxiconazole, nitrile bacterium azoles, tetraconazole, Flutriafol, tricyclazole, and the weight ratio of active components A and active component B is 1: 30～80: 1.The present composition has greater activity to the multiple diseases in various crop, and has obvious synergistic effect, expands fungicidal spectrum.And have that dosage is little, resistance of rainwater washing against, the obvious feature of synergy.
Description
The application is divisional application, and original application is the patent application of Shaanxi Meibang Pesticide Co., Ltd.
" a kind of efficient bactericidal composite containing Hexanaphthene flusulfamide ", the Application No. of original application
201210290305.1, original application day is 2012.08.15.
Technical field
The invention belongs to technical field of pesticide, relate to a kind of efficient sterilizing group containing Hexanaphthene flusulfamide
Compound application in crop pest.
Technical background
Hexanaphthene flusulfamide chemical name: N-(2-trifluoromethyl-4-chlorophenyl)-a-oxocyclohex
Base sulfonamide.It has stronger prevention, treatment and osmotically active, and has higher lasting effect.
Show through field test results, Hexanaphthene flusulfamide can effectively prevent and treat gray mold, sclerotinia rot of colza,
Cucumber Target Leaf Spot and scab.
In the real process of agricultural production, controlling disease is easiest to generate the problem that disease resists
The generation of the property of medicine.Different cultivars composition compounds, and is to prevent and treat the method that resistance disease is the most common.
Heterogeneity compounds, according to practical application effect, judge certain compounding be synergy, add
With still antagonism.In most cases, the compounding effect of agricultural chemicals is all additive effect,
Really have synergistic effect compounding seldom, especially synergistic effect clearly, synergy ratio very
High is compounding the most less.Study through inventor, find by Hexanaphthene flusulfamide and Flusilazole,
Epoxiconazole, nitrile bacterium azoles, tetraconazole, Flutriafol, tricyclazole are the most compounding, in certain limit
Inside have a good synergistic effect, and about Hexanaphthene flusulfamide and Flusilazole, epoxiconazole, nitrile bacterium azoles,
Tetraconazole, Flutriafol, tricyclazole are relevant compounding, the most at home and abroad there is not yet relevant report.
Summary of the invention
The purpose of the present invention is to propose to one and have that synergistic function, use cost be low, preventive effect
The good efficient bactericidal composite containing Hexanaphthene flusulfamide.
The present invention is to be achieved through the following technical solutions:
A kind of efficient bactericidal composite containing Hexanaphthene flusulfamide, containing active components A and activity
Composition B, active components A and active component B weight ratio are 1: 30～80: 1, described
Active components A is selected from Hexanaphthene flusulfamide, and active component B is selected from Flusilazole, epoxiconazole, nitrile
One in bacterium azoles, tetraconazole, Flutriafol, tricyclazole；Be preferably active components A with
The preferred weight ratio of active component B is 1 20～60 1；More preferably Hexanaphthene flusulfamide with
The weight ratio of Flusilazole is 1: 5～30: 1, and Hexanaphthene flusulfamide is 1 with the weight ratio of epoxiconazole:
10～20: 1, Hexanaphthene flusulfamide is 1: 5～30: 1 with the weight ratio of nitrile bacterium azoles, hexamethylene sulphur
Bacterium amine is 1: 5～30: 1 with the weight ratio of tetraconazole, Hexanaphthene flusulfamide and the weight of Flutriafol
Amount ratio is 1: 10～20: 1, and Hexanaphthene flusulfamide is 1: 10～20 with the weight ratio of tricyclazole:
1；Most preferably Hexanaphthene flusulfamide is 1: 1～14: 1 with the weight ratio of Flusilazole, hexamethylene sulphur
Bacterium amine is 1: 4～14: 1 with the weight ratio of epoxiconazole, Hexanaphthene flusulfamide and the weight of nitrile bacterium azoles
Ratio is 1: 1～19: 1, and Hexanaphthene flusulfamide is 1: 1～19: 1 with the weight ratio of tetraconazole,
Hexanaphthene flusulfamide is 1 4～9 1 with the weight ratio of Flutriafol, Hexanaphthene flusulfamide and tricyclazole
Weight ratio be 1 4～9 1.
The described efficient bactericidal composite containing Hexanaphthene flusulfamide, composition make wettable powder,
Water dispersible granules, suspending agent, aqueous emulsion, microemulsion, suspension emulsion, microcapsule suspending agent, micro-capsule
Suspension-suspending agent.
The described efficient bactericidal composite containing Hexanaphthene flusulfamide is for preventing and treating the disease of crop；Institute
The crop stated include cereal crops, legume crop, fibre crops, sugar crop, melon crop,
Fruits crop, dry fruit crop, hobby crop, root crop, oil crops, flowers
Crop, medicinal crop, crop, green manure pasture crop；Described disease include powdery mildew,
Spot defoliation, gray mold, brown spot, scab, sclerotiniose, leaf spot, rust,
Glume blight, rust, damping-off, eyeprint disease, graywall, smut, moire disease, rice blast,
Anthracnose, banded sclerotial blight, brown rot, rice blast, head blight, bakanae disease.
In the bactericidal composition of the present invention, the content of active component depends on executing when being used alone
Consumption, also depends on a kind of compound and the mixed ratio of another kind of compound and synergistic effect
Degree, also the most relevant with target disease.Generally in composition, the weight percent of active component contains
Amount is the 1%～90% of gross weight, is preferably 5%～80%.According to different preparation types,
Active component content scope is different.Generally, liquid preparation contains by weight 1%～60%
Active material, preferably 5%～50%；Solid pharmaceutical preparation contains by weight 5%～80%
Active material, preferably 10%～80%.
The bactericidal composition of the present invention at least contains a kind of surfactant, when being beneficial to use
Active component dispersion in water.Surface-active contents is the 2%～30% of total formulation weight amount,
Surplus is solid or liquid diluent.
The bactericidal composition of invention through dilution or directly can be used before use by user.Its
Preparation can be prepared by processing method known in those skilled in the art, will active component and liquid
After body solvent or solid carrier mixing, add surfactant such as dispersant, wetting agent, glue
One or more in knot agent, defoamer etc..According to different dosage form, preparation can also contain this
Stabilizer well known to skilled person, antifreeze etc..
Composition comprises following component and content when making wettable powder: active components A
0.5%～80%, active component B 0.5%～60%, dispersant 1%～12%, wetting agent 1%～8%,
Filler surplus.
Composition includes following component and content when making water dispersible granules: active components A
0.5%～80%, active component B 0.5%～60%, dispersant 1%～12%, wetting agent 1%～8%,
Disintegrant 1%～10%, binding agent 0～8%, filler surplus.
Composition includes following component and content when making suspending agent: active components A
0.5%～50%, active component B 0.5%～50%, dispersant 1%～10%, wetting agent 1%～10%,
Defoamer 0.01%～2%, thickener 0～2%, antifreeze 0～8%, deionized water add to 100%.
Composition includes following component and content when making aqueous emulsion: active components A
0.5%～50%, active component B 0.5%～50%, solvent 1%～20%, emulsifying agent 1%～12%,
Antifreeze 0～8%, defoamer 0.01%～2%, thickener 0～2%, deionized water add to 100%.
Composition includes following component and content when making microemulsion: active component
A0.5%～50%, active component B 0.5%～50%, emulsifying agent 3%～25%, solvent 1%～10%,
Antifreeze 0～8%, defoamer 0.01%～2%, deionized water add to 100%.
Composition includes following component and content when making suspension emulsion: active components A
0.5%～50%, active component B 0.5%～50%, emulsifying agent 1%～10%, dispersant 1%～10%,
Solvent 1%～20%, defoamer 0.01%～2%, thickener 0～2%, antifreeze 0～8%, go
Ionized water adds to 100%.
Composition includes following component and content when making microcapsule suspending agent: active components A
0.5%～50%, active component B 0.5%～50%, macromolecule cyst material 1%～10%, dispersion
Agent 2%～10%, solvent 1%～10%, emulsifying agent 1%～7%, pH adjusting agent 0.01%～5%,
Defoamer 0.01%～2%, deionized water add to 100%.
Composition includes following component and content when making microcapsule suspension-suspendinagent agent: active component
A0.5%～50%, active component B 0.5%～50%, macromolecule cyst material 1%～12%, point
Powder 1%～12%, wetting agent 1%～8%, solvent 1%～15%, emulsifying agent 1%～8%, disappear
Infusion 0.01%～2%, thickener 0～2%, pH adjusting agent 0.01%～5%, deionized water add
To 100%.
The wettable powder the key technical indexes of the present invention:
The water dispersible granules the key technical indexes of the present invention:
The suspending agent the key technical indexes of the present invention:
The aqueous emulsion the key technical indexes of the present invention:
The microemulsion the key technical indexes of the present invention:
The suspension emulsion the key technical indexes of the present invention:
The microcapsule suspending agent the key technical indexes of the present invention:
The microcapsule suspension-suspendinagent agent the key technical indexes of the present invention:
It is an advantage of the current invention that:
(1) present composition has good synergy and lasting effect within the specific limits, anti-
Effect is higher than single dose；(2) pesticide usage amount reduces, and reduces agricultural chemicals residual quantity on crop, subtracts
Light environmental pollution；(3) expand fungicidal spectrum, to multiple diseases such as powdery mildew, spot defoliation,
Gray mold, brown spot, scab, sclerotiniose, leaf spot, rust, glume blight, rust,
Damping-off, eyeprint disease, graywall, smut, moire disease, rice blast, anthracnose, line are withered
Disease, brown rot, rice blast, head blight, bakanae disease have greater activity.
Detailed description of the invention
Below in conjunction with embodiment, further instruction of the present invention, the percentage in embodiment are
Percentage by weight, but the invention is not limited in this.
Application Example one
Embodiment 1～15 wettable powder
By Hexanaphthene flusulfamide, active component B, dispersant, wetting agent, filler mixing, mixed
Close in cylinder and mix, remix uniformly after airslide disintegrating mill is pulverized, i.e. can be made into the present invention
Described wettable powder product.Specifically it is shown in Table 1,2,3.
Table 1 embodiment 1～5 each component and content
Table 2 embodiment 6～10 each component and content
Table 3 embodiment 11～15 each component and content
Embodiment 16～30 water dispersible granules
By Hexanaphthene flusulfamide, active component B, dispersant, wetting agent, disintegrant, filler etc.
Obtain the particle diameter needed together through air-flow crushing, add binding agent (can add and can be not added with) etc. its
Its auxiliary agent, obtains granulation materials.System is passed through in item is quantitatively sent into fluidized bed granulating dryer
Grain and dried, can be prepared by water dispersible granules product of the present invention, be specifically shown in Table 4,
5、6。
Table 4 embodiment 16～20 each component and content
Table 5 embodiment 21～25 each component and content
Table 6 embodiment 26～30 each component and content
Embodiment 31～45 suspending agent
By dispersant, wetting agent, defoamer, thickener (can add and can be not added with), antifreeze (can
Add and can be not added with), mix through high speed shear, add Hexanaphthene flusulfamide, active component B,
Ball milling 2～3 hours in ball mill, make diameter of particle all below 5 μm, and surplus spends
Ionized water is supplied, and can be prepared by suspending agent product of the present invention, is specifically shown in Table 7,8,9.
Table 7 embodiment 31～35 each component and content
Table 8 embodiment 36～40 each component and content
Table 9 embodiment 41～45 each component and content
Embodiment 46～55 aqueous emulsion
Hexanaphthene flusulfamide, active component B, solvent, emulsifying agent are added together, make to be dissolved into
Homogeneous oil phase；By deionized water, antifreeze (can add and can be not added with), (can add can not for thickener
Add), defoamer mix, become homogeneous aqueous phase.Under high velocity agitation, aqueous phase is added
Oil phase, prepares aqueous emulsion product of the present invention.Specifically it is shown in Table 10,11.
Table 10 embodiment 46～50 each component and content
Table 11 embodiment 51～55 each component and content
By Flusilazole in table 1～11, epoxiconazole, nitrile bacterium azoles, tetraconazole, Flutriafol, three
Ring azoles exchanges, and can prepare novel formulation.
Embodiment 56～60 microemulsion
Hexanaphthene flusulfamide, active component B are dissolved in equipped with in the homogenizer of solvent, by breast
Agent, antifreeze (can add and can be not added with), defoamer, join the homogenizing equipped with above-mentioned solution
In device, surplus deionized water strongly mixes after supplying and homogenizes, and finally obtains outward appearance clear
Clear transparent microemulsion product of the present invention.Specifically it is shown in Table 12.
Table 12 embodiment 56～60 each component and content
Embodiment 61～64 suspension emulsion
By dispersant, defoamer, thickener (can add and can be not added with), (can add can not for antifreeze
Add) mix through high speed shear, add Hexanaphthene flusulfamide, ball milling 2～3 in ball mill
Hour, make diameter of particle all below 5 μm, prepare Hexanaphthene flusulfamide suspending agent, then
Active component B, emulsifying agent, solvent and various auxiliary agent high speed agitator are directly emulsified outstanding
In floating agent, prepare suspension emulsion product of the present invention.Specifically it is shown in Table 13.
Table 13 embodiment 61～64 each component and content
Embodiment 65～68 microcapsule suspending agent
By Hexanaphthene flusulfamide, active component B, macromolecule cyst material, solvent mixing, make molten
Solution uniformly oil phase, in a shear condition, joins oil phase containing emulsifying agent, pH regulation
Agent, dispersant, defoamer aqueous phase solution in, surplus deionized water is supplied, bi-material
React at oil-water interfaces, form macromolecule cyst wall, make present composition good dispersion
Microcapsule suspending agent product.Specifically it is shown in Table 14.
Table 14 embodiment 65～68 each component and content
Embodiment 69～72 microcapsule suspension-suspendinagent agent
By active component B, macromolecule cyst material, solvent mixing, make to be dissolved into homogeneous oil phase,
Oil phase is joined in a shear condition containing emulsifying agent, pH adjusting agent aqueous phase solution in,
Make finely disseminated microcapsule suspending agent.By dispersant, wetting agent, defoamer, thickener (can
Add and can be not added with) mix through high speed shear, add Hexanaphthene flusulfamide, ball in ball mill
Grind 2～3 hours, make diameter of particle all below 5 μm, prepare suspending agent, then will be outstanding
Floating agent joins in the aqueous phase solution of micro-capsule suspension, and deionized water supplies surplus, makes this
Inventive composition finely disseminated microcapsule suspension-suspendinagent agent product.Specifically it is shown in Table 15.
Table 15 embodiment 69～72 each component and content
The embodiment of the present invention is the method using Toxicity Determination and field test to combine.First
Synergy ratio by Toxicity Determination, after clear and definite two kinds of medicaments are compounding by a certain percentage
(SR), SR ＜ 0.5 is antagonism, and 0.5≤SR≤1.5 are summation action, SR ＞ 1.5
For synergistic effect, on this basis, then carry out field test.
Test method: after prerun determines each medicament effective inhibition concentration scope, medicament is by effectively
Component content sets 5 dosage respectively and processes, if clear water comparison.With reference to " agricultural chemicals indoor biological is surveyed
Determine test rule bactericide " carry out, use mycelial growth rate method to measure medicament to crop germ
Virulence.After 72h with right-angled intersection method measure colony diameter, calculate each process net growth,
Mycelial growth inhibition rate.
Net growth (mm)=measurement colony diameter-5
Mycelial growth inhibition rate is converted into probit value (y), and liquor strength (μ g/mL) is changed
Become logarithm value (x), try to achieve virulence regression equation (y=a+bx) with least square method, and thus
Calculate the EC of every kind of medicament50Value.Calculate two medicament different ratio according to Wadley method simultaneously
Synergy ratio (SR), SR ＜ 0.5 is antagonism, and 0.5≤SR≤1.5 are made for being added
With, SR ＞ 1.5 is synergistic effect.Computing formula is as follows:
Wherein: a, b are respectively the ratio that active components A is shared in combination with active component B；
A is Hexanaphthene flusulfamide；
B is in Flusilazole, epoxiconazole, nitrile bacterium azoles, tetraconazole, Flutriafol, tricyclazole
One.
Application Example two:
For examination disease: pear scab, test medicine is carried by Shaanxi Meibang Pesticide Co., Ltd.
Confession, experimental design: determine Hexanaphthene flusulfamide and both Flusilazoles different ratio through pilot study
Effective inhibition concentration scope of mixture.
Toxicity test result
Table 16 Hexanaphthene flusulfamide toxicity test analysis of results table to pear scab compounding with Flusilazole
As shown in Table 16, Hexanaphthene flusulfamide and Flusilazole compound the proportioning of preventing and treating pear scab
When 1 30～80 1, synergy ratio SR is all higher than 1.5, illustrates that both are 1 30～80
In the range of 1, mixture all shows the proportioning of synergistic effect, Hexanaphthene flusulfamide and Flusilazole 1:
5～30: 1, synergistic effect is the most prominent, and synergy ratio is all more than 2.30.Through applicant
Test finds that Hexanaphthene flusulfamide is 30 1,25 1,20 1,15 with the proportioning of Flusilazole
1,14 1,13 1,12 1,11 1,10 1,91,81,71,61,
51,41,31,21,11,15, wherein Hexanaphthene flusulfamide and Flusilazole weight
Amount is more maximum than for synergy ratio during 8:1, and synergistic effect is the most obvious.
Application Example three:
For examination disease: alternaria leaf spot of apple, test medicine is by Shaanxi nation of U.S. limited public affairs of agricultural chemicals
Department provides, experimental design: determine Hexanaphthene flusulfamide and epoxiconazole raw drug and two through pilot study
Effective inhibition concentration scope of person's different ratio mixture
Toxicity test result
Table 17 Hexanaphthene flusulfamide toxicity test analysis of results table to alternaria leaf spot of apple compounding with epoxiconazole
As shown in Table 17, Hexanaphthene flusulfamide and epoxiconazole compound preventing and treating alternaria leaf spot of apple
Proportioning is when 1 30～80 1, and synergy ratio SR is all higher than 1.5, illustrates that both are 1
In the range of 30～80 1, mixture all shows synergistic effect, and Hexanaphthene flusulfamide is joined with epoxiconazole
Ratio is 1 10～20: 1, and synergistic effect is the most prominent, and synergy ratio is all more than 2.30.
Test through applicant and find that Hexanaphthene flusulfamide is 20 1,15 1,10 with the proportioning of epoxiconazole
1,91,81,71,61,51,41,31,21,11,1
2,13,14,15,1 10, wherein Hexanaphthene flusulfamide with epoxiconazole weight ratio is
During 5:1, synergy ratio is maximum, and synergistic effect is the most obvious.
Application Example four:
For examination disease: powdery mildew of cucumber, test medicine is carried by Shaanxi Meibang Pesticide Co., Ltd.
Confession, experimental design: through pilot study determine Hexanaphthene flusulfamide and bulk myclobutanil and the two not
Effective inhibition concentration scope with proportioning mixture.
Toxicity test result
Table 18 Hexanaphthene flusulfamide and the myclobutanil compositional toxicity test analysis of results table to powdery mildew of cucumber
As shown in Table 18, Hexanaphthene flusulfamide and myclobutanil compositional prevent and treat the proportioning of powdery mildew of cucumber
When 1 30～80 1, synergy ratio SR is all higher than 1.5, illustrates that both are 1 30～80
In the range of 1, mixture all shows the proportioning of synergistic effect, Hexanaphthene flusulfamide and nitrile bacterium azoles 1:
5～30: 1, synergistic effect is the most prominent, and synergy ratio is all more than 2.25.Through applicant
Test finds that Hexanaphthene flusulfamide is 30 1,25 1,20 1,19 with the proportioning of nitrile bacterium azoles
1,18 1,17 1,16 1,15 1,14 1,13 1,12 1,11 1,
10 1,91,81,71,61,51,11,15, wherein hexamethylene sulphur
When bacterium amine and nitrile bacterium azoles weight ratio are 11:1, synergy ratio is maximum, and synergistic effect is the most obvious.
Application Example five:
For examination disease: powdery mildew of strawberry, test medicine is carried by Shaanxi Meibang Pesticide Co., Ltd.
Confession, experimental design: through pilot study determine Hexanaphthene flusulfamide and the former medicine of tetraconazole and the two
Effective inhibition concentration scope of different ratio mixture.
Toxicity test result
Table 19 Hexanaphthene flusulfamide toxicity test analysis of results table to powdery mildew of strawberry compounding with tetraconazole
As shown in Table 19, Hexanaphthene flusulfamide and tetraconazole compound joining of preventing and treating powdery mildew of strawberry
Ratio is when 1 30～80 1, and synergy ratio SR is all higher than 1.5, illustrates that both are 1 30～80
In the range of 1, mixture all shows synergistic effect, and Hexanaphthene flusulfamide exists with the proportioning of tetraconazole
1: 5～30: 1, synergistic effect is the most prominent, and synergy ratio is all more than 2.20.Through Shen
Ask someone test find the proportioning of Hexanaphthene flusulfamide and tetraconazole be 30 1,25 1,20 1,
19 1,18 1,17 1,16 1,15 1,14 1,13 1,12 1,11
1,10 1,91,81,71,61,51,15, wherein hexamethylene sulphur bacterium
When amine and tetraconazole weight ratio are 12:1, synergy ratio is maximum, and synergistic effect is the most obvious.
Application Example six:
For examination disease: wheat rust, test medicine is provided by Shaanxi Meibang Pesticide Co., Ltd.,
Experimental design: through pilot study determine the former medicine of Hexanaphthene flusulfamide and Flutriafol and the two different join
Effective inhibition concentration scope than mixture.
Table 20 Hexanaphthene flusulfamide toxicity test analysis of results table to wheat rust compounding with Flutriafol
As shown in Table 20, Hexanaphthene flusulfamide and Flutriafol compound and prevent and treat the proportioning of wheat rust and exist
When 1 30～80 1, synergy ratio SR is all higher than 1.5, illustrates that both are 1 30～80 1
In the range of mixture all show synergistic effect, the proportioning of Hexanaphthene flusulfamide and Flutriafol at 1:10～
20: 1, synergistic effect is the most prominent, and synergy ratio is all more than 2.20.Try through applicant
Issue after examination and approval the proportioning of existing Hexanaphthene flusulfamide and Flutriafol be 20 1,15 1,10 1,91,
81,71,61,51,41,31,21,11,12,13,
14,15,1 10, synergy when wherein Hexanaphthene flusulfamide and Flutriafol weight ratio are 3:1
Ratio is maximum, and synergistic effect is the most obvious.
Application Example seven:
For examination disease: rice blast, test medicine is carried by Shaanxi Meibang Pesticide Co., Ltd.
Confession, experimental design: through pilot study determine Hexanaphthene flusulfamide and Mensurating Tricyclazole Technical and the two not
Effective inhibition concentration scope with proportioning mixture.
Table 21 Hexanaphthene flusulfamide toxicity test analysis of results table to rice blast compounding with tricyclazole
As shown in Table 21, Hexanaphthene flusulfamide and tricyclazole compound the proportioning of preventing and treating rice blast and exist
When 1 30～80 1, synergy ratio SR is all higher than 1.5, illustrates that both are 1 30～80 1
In the range of mixture all show synergistic effect, the proportioning of Hexanaphthene flusulfamide and tricyclazole at 1:10～
20: 1, synergistic effect is the most prominent, and synergy ratio is all more than 2.20.Test through applicant
Find that Hexanaphthene flusulfamide is 20 1,15 1,10 1,91,8 with the proportioning of tricyclazole
1,71,61,51,41,31,21,11,12,13,1
4,15,1 10, synergic ratio when wherein Hexanaphthene flusulfamide and tricyclazole weight ratio are 2:1
Value maximum, synergistic effect is the most obvious.
Find through test: in various crop after Hexanaphthene flusulfamide is compounding with active component B
Powdery mildew, spot defoliation, gray mold, brown spot, scab, sclerotiniose, leaf spot,
Rust, glume blight, rust, damping-off, eyeprint disease, graywall, smut, moire disease,
Rice blast, anthracnose, banded sclerotial blight, brown rot, rice blast, head blight, the preventing and treating of bakanae disease
Having obvious synergistic effect, synergy ratio is all more than 1.5.
Effect experiment part: test medicine is researched and developed by Shaanxi Meibang Pesticide Co., Ltd., provided, right
According to medicament 20% Hexanaphthene flusulfamide suspending agent (autogamy), 10% Flusilazole aqueous emulsion (commercial),
12.5% epoxiconazole suspension concentrate (commercial), 12% nitrile bacterium azoles missible oil (commercial), 4% tetraconazole
Aqueous emulsion (commercial), 12.5% Flutriafol suspending agent (commercial), 20% tricyclazole suspending agent (city
Purchase).
Application Example eight Hexanaphthene flusulfamide and active component B and compounding preventing and treating graw mold of tomato effect thereof
Test
This EE investigates the graw mold of tomato state of an illness before Xi'an City, Shanxi Province, medicine, in the state of an illness
Initial stage dispenser for the first time, dispenser in every 7 days once, is total to dispenser 2 times.For the second time after dispenser 7 days,
Within 14 days, 30 days, investigate disease index respectively and calculate preventive effect.Experimental result is as follows:
Table 22 Hexanaphthene flusulfamide and active component B and the compounding preventing and treating graw mold of tomato test of pesticide effectiveness thereof
As can be seen from Table 22, Hexanaphthene flusulfamide and active component B and compounding after can be effective
Preventing and treating graw mold of tomato, prevention effect is superior to the preventive effect of single dose, and the preventive effect phase is long.In test
In scope of medication, target crop is had no adverse effects.
Application Example nine Hexanaphthene flusulfamide and active component B and compounding prevent and treat beet cercospora leaf spot medicine
Effect test
This test arrangement investigates the beet cercospora leaf spot state of an illness before Xi'an City, Shanxi Province, medicine, in the state of an illness
Initial stage dispenser for the first time, dispenser in every 7 days once, is total to dispenser 2 times.For the second time after dispenser 3 days,
Within 7 days, 15 days, investigate disease index respectively and calculate preventive effect.Experimental result is as follows:
Table 23 Hexanaphthene flusulfamide and active component B and compounding prevent and treat the beet cercospora leaf spot test of pesticide effectiveness
As can be seen from Table 23, Hexanaphthene flusulfamide and active component B and compounding after can be effective
Preventing and treating beet cercospora leaf spot, prevention effect is superior to the preventive effect of single dose, and the preventive effect phase is long.In test
In scope of medication, target crop is had no adverse effects.
Application Example ten Hexanaphthene flusulfamide and active component B and compounding preventing and treating pear scab medicine thereof
Effect test
This test arrangement, in Xianyang, Shanxi province city, investigates the pear scab state of an illness, in the state of an illness before medicine
Initial stage dispenser for the first time, dispenser in every 7 days once, is total to dispenser 2 times.For the second time after dispenser 7 days,
Within 14 days, 30 days, investigate disease index respectively and calculate preventive effect.Experimental result is as follows:
Table 24 Hexanaphthene flusulfamide and active component B and the compounding preventing and treating pear scab test of pesticide effectiveness thereof
As can be seen from Table 24, Hexanaphthene flusulfamide is prevented with active component B and compounding rear efficiency thereof
Controlling pear scab, prevention effect is superior to the preventive effect of single dose, and the preventive effect phase is long.Use in test
In the range of medicine, target crop is had no adverse effects.
Application Example 11 Hexanaphthene flusulfamide and active component B and compounding preventing and treating rice blast thereof
The test of pesticide effectiveness
This test arrangement, at Shaanxi Province's Hanzhong City, investigates the rice blast state of an illness, in the state of an illness before medicine
Initial stage dispenser for the first time, dispenser in every 7 days once, is total to dispenser 2 times.For the second time after dispenser 7 days,
Within 14 days, 30 days, investigate disease index respectively and calculate preventive effect.Experimental result is as follows:
Table 25 Hexanaphthene flusulfamide and active component B and the compounding preventing and treating rice blast test of pesticide effectiveness thereof
As can be seen from Table 25, Hexanaphthene flusulfamide and active component B and compounding after can be effective
Preventing and treating rice blast, prevention effect is superior to the preventive effect of single dose, and the preventive effect phase is long.In test
In scope of medication, target crop is had no adverse effects.
Application Example 12 Hexanaphthene flusulfamide and active component B and compounding prevent and treat sigatoka
The test of pesticide effectiveness
This EE investigates the sigatoka state of an illness before Nanning, medicine, at the beginning of the state of an illness
Phase dispenser for the first time, dispenser in every 7 days once, is total to dispenser 2 times.For the second time after dispenser 7 days,
Within 14 days, 30 days, investigate disease index respectively and calculate preventive effect.Experimental result is as follows:
Table 26 Hexanaphthene flusulfamide and active component B and compounding prevent and treat the sigatoka test of pesticide effectiveness
As can be seen from Table 26, Hexanaphthene flusulfamide and active component B and compounding after can be effective
Preventing and treating sigatoka, prevention effect is superior to the preventive effect of single dose, and the preventive effect phase is long.In test
In scope of medication, target crop is had no adverse effects.
Application Example 13 Hexanaphthene flusulfamide and active component B and compounding preventing and treating uncinula necator thereof
The test of pesticide effectiveness
This test arrangement, at Shaanxi Province's Weinan City, investigates the uncinula necator state of an illness, in the state of an illness before medicine
Initial stage dispenser for the first time, dispenser in every 7 days once, is total to dispenser 2 times.For the second time after dispenser 7 days,
Within 14 days, 30 days, investigate disease index respectively and calculate preventive effect.Experimental result is as follows:
Table 27 Hexanaphthene flusulfamide and active component B and the compounding preventing and treating uncinula necator test of pesticide effectiveness thereof
As can be seen from Table 27, Hexanaphthene flusulfamide and active component B and compounding after can be effective
Preventing and treating uncinula necator, prevention effect is superior to the preventive effect of single dose, and the preventive effect phase is long.In test
In scope of medication, target crop is had no adverse effects.
Application Example 14 Hexanaphthene flusulfamide and active component B and compounding preventing and treating sclerotinia rot of colza thereof
The test of pesticide effectiveness
This test arrangement, at Shaanxi Province's Hanzhong City, investigates the sclerotinia rot of colza state of an illness, in the state of an illness before medicine
Initial stage dispenser for the first time, dispenser in every 7 days once, is total to dispenser 2 times.For the second time after dispenser 7 days,
Within 14 days, 30 days, investigate disease index respectively and calculate preventive effect.Experimental result is as follows:
Table 28 Hexanaphthene flusulfamide and active component B and the compounding preventing and treating sclerotinia rot of colza test of pesticide effectiveness thereof
As can be seen from Table 28, Hexanaphthene flusulfamide and active component B and compounding after can be effective
Preventing and treating sclerotinia rot of colza, prevention effect is superior to the preventive effect of single dose, and the preventive effect phase is long.In test
In scope of medication, target crop is had no adverse effects.
After draw through tests different local throughout the country, Hexanaphthene flusulfamide and Flusilazole,
To in various crop after epoxiconazole, nitrile bacterium azoles, tetraconazole, Flutriafol, tricyclazole are compounding
Powdery mildew, spot defoliation, gray mold, brown spot, scab, sclerotiniose, leaf spot,
Rust, glume blight, rust, damping-off, eyeprint disease, graywall, smut, moire disease,
Rice blast, anthracnose, banded sclerotial blight, brown rot, rice blast, head blight, bakanae disease etc. are common
The preventive effect of disease all 95% with on excellent, in single dose preventive effect, synergistic effect is obvious.
Claims (6)
1. the efficient bactericidal composite containing Hexanaphthene flusulfamide, it is characterized in that: active ingredient is active components A and active component B, active components A and active component B weight ratio are 1: 30～80: 1, and described active components A is Hexanaphthene flusulfamide, and active component B is Flutriafol.
Efficient bactericidal composite containing Hexanaphthene flusulfamide the most according to claim 1, it is characterised in that: active components A is 1: 20～60: 1 with the weight ratio of active component B.
Efficient bactericidal composite containing Hexanaphthene flusulfamide the most according to claim 2, it is characterised in that:
Hexanaphthene flusulfamide is 1: 10～20: 1 with the weight ratio of Flutriafol.
4. according to the efficient bactericidal composite containing Hexanaphthene flusulfamide according to any one of claims 1 to 3, it is characterised in that: composition makes wettable powder, water dispersible granules, suspending agent, aqueous emulsion, microemulsion, suspension emulsion, microcapsule suspending agent, microcapsule suspension-suspendinagent agent.
5. the efficient bactericidal composite containing Hexanaphthene flusulfamide described in claim 4 is for preventing and treating the purposes of crop pest.
Purposes the most according to claim 5, it is characterised in that: described disease includes powdery mildew, spot defoliation, gray mold, brown spot, scab, sclerotiniose, leaf spot, rust, glume blight, rust, damping-off, eyeprint disease, graywall, smut, moire disease, rice blast, anthracnose, banded sclerotial blight, brown rot, head blight, bakanae disease.
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| CN1900059A (en) * | 2005-07-20 | 2007-01-24 | 中国农业大学 | 2-keto naphthene sulfamide, its preparing method and use as germicide |
| CN101720764A (en) * | 2008-10-13 | 2010-06-09 | 中国农业大学 | New application of N-(2-trifluoromethyl-4-chlorphenyl)-alpha-oxocyclohexyl sulfamide as sterilizing agent |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1900059A (en) * | 2005-07-20 | 2007-01-24 | 中国农业大学 | 2-keto naphthene sulfamide, its preparing method and use as germicide |
| CN101720764A (en) * | 2008-10-13 | 2010-06-09 | 中国农业大学 | New application of N-(2-trifluoromethyl-4-chlorphenyl)-alpha-oxocyclohexyl sulfamide as sterilizing agent |
Non-Patent Citations (2)
| Title |
|---|
| 创制杀菌剂-环己磺菌胺;张海滨;《农药》;20120430;第51卷(第4期);第287-288页 * |
| 新颖杀菌剂-环己磺菌胺;中国农业大学，南通江山农药化工股份有限公司;《世界农药》;20120630;第34卷(第3期);第56页 * |
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Address after: 715500 Pucheng high tech Industrial Development Zone, Weinan, Shaanxi Patentee after: SHAANXI MEIBANG PHARMACEUTICAL GROUP Co.,Ltd. Address before: 715500 Shaanxi Pucheng Weinan County agricultural base industrial park Patentee before: Shaanxi Meibang pesticide Co.,Ltd. |
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