CN104224269A - Hemostasis bag, hemostasis pressing assembly and hemostasis device - Google Patents
Hemostasis bag, hemostasis pressing assembly and hemostasis device Download PDFInfo
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- CN104224269A CN104224269A CN201310235177.5A CN201310235177A CN104224269A CN 104224269 A CN104224269 A CN 104224269A CN 201310235177 A CN201310235177 A CN 201310235177A CN 104224269 A CN104224269 A CN 104224269A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12009—Implements for ligaturing other than by clamps or clips, e.g. using a loop with a slip knot
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
- A61B17/12109—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B2017/12004—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord for haemostasis, for prevention of bleeding
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Abstract
The invention provides a hemostasis bag, a hemostasis pressing assembly and a hemostasis device. The hemostasis bag comprises a semi-permeable membrane and a water-absorbing material, wherein the semi-permeable membrane is provided with holes for blocking blood platelets and/or blood cells and allowing water molecules to pass through, and the water-absorbing material is arranged on the opposite side of the side, for blocking the blood platelets and/or the blood cells, of the semi-permeable membrane and used for absorbing moisture in blood at a bleeding part through the holes of the semi-permeable membrane so that the effect of accelerating the hemostasis can be achieved.
Description
Technical field
The present invention relates to medical instruments field, being specifically related to the hemostasis bag for stopping blooding, hemostasis pushing assembly and hemostasis device.
Background technology
Usually, hemostasis is the first step for the treatment of of wounds.Over more than 1000 year, hemorrhage is used to prevent from bleeding.Along with the fast development of hemostatic technique, hemostasia products also achieves sizable progress.Most of existing hemostatic material adopts the other materials such as collagen (gelatin or collagen protein), cellulose, chitosan (chitosan), porous material (zeolite) or Chinese medicine (TCM) usually.Most of hemostatic material, such as collagen, chitosan, starch, fibrin, cellulose are all from biogenic, they may exist cause human body to stimulate, the potential risk of irritated and inflammation.Zeolite or kaolinite are the principle active component of QuikClot, and QuikClot or similar hemostatic material can quick-acting haemostatic powders, but may have and produce heating functioin and the potential risk causing secondary to burn.In addition, such as YUNNAN BAIYAO etc. can be used to the Chinese medicine stopped blooding, and be generally used for applying the less outer injury of wound, application scenario is comparatively limited to.
Therefore, truly have the hemostasia products needing to develop a kind of advanced person, it can overcome above-mentioned shortcoming.
Summary of the invention
Object of the present invention is intended at least one aspect solving the above-mentioned problems in the prior art and defect.
Due to hemostasis provided by the invention bag, hemostasis pushing assembly and hemostasis device comprise a kind of have stop platelet and/or hemocyte and the semipermeable membrane in the hole that hydrone is passed through, so hemostasis bag provided by the invention, hemostasis pushing assembly or hemostasis device are placed on bleeding part, the platelet at bleeding part place and/or the concentration of blood cell can be increased in, thus accelerate the coagulation process of bleeding part, play the effect accelerating hemostasis.
According to an aspect of the present invention, the invention provides a kind of hemostasis bag, wherein, described hemostasis handbag is drawn together:
Semipermeable membrane, described semipermeable membrane has and stops platelet and/or hemocyte and the hole that hydrone is passed through; With
Absorptive substance, described absorptive substance is arranged on the opposite side that described semipermeable membrane stops platelet and/or hemocyte side, for the moisture in the blood at absorption bleeding part, the hole place through described semipermeable membrane, thus plays the effect accelerating hemostasis.
According to a further aspect in the invention, the invention provides a kind of hemostasis bag, wherein, described hemostasis handbag is drawn together:
At least one semi-transparent rete, described semi-transparent rete has and stops platelet and/or hemocyte and the hole that hydrone is passed through; With
Absorptive substance, described absorptive substance is clamped in the center of semi-transparent rete or the centre of semi-transparent rete, for the moisture in the blood at absorption bleeding part, the hole place through described semi-transparent rete, thus plays the effect accelerating hemostasis.
According to a further aspect in the invention, the invention provides a kind of hemostasis pushing assembly, wherein, described hemostasis pushing assembly comprises:
Pressure providing unit, and
According to above-mentioned hemostasis bag provided by the invention, described hemostasis bag is arranged on or is connected in described pressure providing unit.
According to a further aspect in the invention, the invention provides a kind of hemostasis device, wherein, described hemostasis device comprises: semipermeable membrane, and described semipermeable membrane has and stops platelet and/or hemocyte and the hole that hydrone is passed through.
Hemostasis bag provided by the invention, hemostasis pushing assembly and hemostasis device at least have the following advantages: (1) reduces in hemostasis the risk causing allergy, stimulation and inflammation; (2) there is good anthemorrhagic performance; (3) unique selective absorbing mechanism is adopted, obviously different from the mechanism of existing hemostasia products.
In addition, hemostasis pushing assembly provided by the invention also has the following advantages further: described hemostasis bag can be stablized and is reliably fixed to and bleed on position, and serve the function of pressing haemostatic, thus not need to stop blooding with hands pressing always.
Accompanying drawing explanation
These and/or other aspect of the present invention and advantage will become obvious and easy understand below in conjunction with in accompanying drawing description of preferred embodiments, wherein:
Fig. 1 is the principle schematic of the hemostasis bag provided according to some of the preferred embodiment of the invention;
Fig. 2 is according to the partial schematic diagram under an electron microscope of the semipermeable membrane in Fig. 1;
Fig. 3 a is the schematic diagram of hemostasis bag and the enlarged diagram of its top-right part that provide according to some of the preferred embodiment of the invention;
Fig. 3 b is the side view of the hemostasis bag in Fig. 3 a;
Fig. 4 is the comparison diagram of hemostasis bag and the haemostatic effect test result of common gauze in rabbit live body spleen breach is tested provided according to some of the preferred embodiment of the invention.
Fig. 5 is the principle schematic of the hemostasis pushing assembly provided according to some of the preferred embodiment of the invention;
Fig. 6 is the comparison diagram of the haemostatic effect test result of hemostasis pushing assembly, common gauze and the femoral artery of QuikClot on rabbit live body provided according to some of the preferred embodiment of the invention.
Detailed description of the invention
Below by embodiment, and by reference to the accompanying drawings, technical scheme of the present invention is described in further detail.In the description, same or analogous drawing reference numeral represents same or analogous parts.The explanation of following reference accompanying drawing to embodiment of the present invention is intended to make an explanation to present general inventive concept of the present invention, and not should be understood to one restriction of the present invention.
Except as otherwise noted, otherwise all numerals of the representation feature size, quantity and the physical characteristic that use in this description and claim be all construed as and all modified by term " about " in all cases.Therefore, unless indicated to the contrary, otherwise the numerical parameter listed in above-mentioned description and appended claims is all approximations, those skilled in the art can utilize instruction content disclosed herein to seek the desirable characteristics obtained, and suitably changes these approximations.The use of the numerical range represented with end points comprises all numerals within the scope of this and any scope within the scope of this, and such as, 1 to 5 comprises 1,1.1,1.3,1.5,2,2.75,3,3.80,4 and 5 etc.
hemostasis bag
Structure and the action principle of hemostasis bag provided by the invention is described in detail below with reference to accompanying drawing.
See Fig. 1 and Fig. 2, hemostasis bag 10 provided by the invention comprises semipermeable membrane (SPM) 1 and absorptive substance 2, described semipermeable membrane 1 has and stops platelet and/or hemocyte and the hole 7 that hydrone is passed through, and described absorptive substance 2 is arranged on the opposite side that described semipermeable membrane stops platelet and/or hemocyte side.
Described hemostasis bag 10 is placed into bleeding part 6 place, hydrone 5 in blood is absorbed by absorptive substance 2 by the hole 7 of described semipermeable membrane 1, platelet 4 in blood and/or blood cell 3 are blocked in the side of semipermeable membrane 1 near bleeding part 6 by semipermeable membrane 1, therefore, described semipermeable membrane 1 improves the platelet 4 at bleeding part 6 place and/or the concentration of blood cell 3, thus accelerate the coagulation process of bleeding part 6, serve the effect accelerating hemostasis.
In addition, by choosing suitable absorptive substance 2, the driving force of the hydrone 5 in described hemostasis bag absorbing blood can also be increased, thus accelerate the coagulation process of bleeding part 6 further.
According to some of the preferred embodiment of the invention, as best shown in figures 3 a and 3b, described semipermeable membrane 1 can be set up the form of stratification or pad, and described absorptive substance 2 can be configured to the form of pad or layer, also can be configured to the form of powder, granule or fiber.
According to some of the preferred embodiment of the invention, described hemostasis bag 10 can comprise two semi-transparent retes, and described semi-transparent rete has and stops platelet 4 and/or hemocyte 3 and the hole 7 that hydrone 5 is passed through; Described absorptive substance 2 (such as, absorptive substance 2 can be configured to pad or the form of layer) be clamped in the centre of two semi-transparent retes, for drawing the moisture in the blood at bleeding part 6 place through the hole 7 of described semi-transparent rete, thus play the effect accelerating hemostasis.
According to some of the preferred embodiment of the invention, described hemostasis bag 10 can comprise a semi-transparent rete, and described semi-transparent rete has and stops platelet 4 and/or hemocyte 3 and the hole 7 that hydrone 5 is passed through; Described absorptive substance 2 (such as, absorptive substance 2 can be configured to pad or the form of layer) be clamped in the center of the centre of described semi-transparent rete or described semi-transparent rete (such as, absorptive substance can be arranged on the centre of folding semi-transparent rete or the center of semi-transparent rete), for drawing the moisture in the blood at bleeding part 6 place through the hole 7 of described semi-transparent rete, thus play the effect accelerating hemostasis.
According to some of the preferred embodiment of the invention, as shown in Figure 2, described semipermeable membrane 1 can comprise the hole 7 of one or more rule or irregular alignment, and described hole 7 has and stops platelet and/or hemocyte and the aperture size that hydrone is passed through.Described platelet and/or hemocyte both can be platelet and/or the hemocyte of the mankind, also can be platelet and/or the hemocyte of other animal.Can by selecting the aperture size in the hole 7 of different semipermeable membrane 1, described semipermeable membrane 1 or the hemostasis bag that comprises described semipermeable membrane 1 are applied in the hemostasis of the mankind or other different animals.
According to some of the preferred embodiment of the invention, described semipermeable membrane 1 can be anyly have the membrane material of the semi-transparent character in suitable hole, any braiding or non-woven materials with suitable hole, the medical film material preferably with the semi-transparent character in suitable hole, the braiding with suitable hole or non-woven medical material.According to some of the preferred embodiment of the invention, the aperture size in the hole 7 of described semipermeable membrane 1 is 0.01-15 μm, and such as described aperture size can be 1 μm, 5 μm or 11 μm.Because the diameter of the various hemocytees in human blood 3 (such as erythrocyte, leukocyte) is approximately 8-12 μm, the diameter of platelet 4 is about 5-8 μm, the diameter of hydrone is about 0.4nm, so the hydrone 5 in human blood is absorbed by absorptive substance 2 by the hole 7 of described semipermeable membrane 1, the platelet 4 in blood and/or blood cell 3 are blocked in the side of semipermeable membrane 1 near bleeding part 6 by semipermeable membrane 1.
According to some of the preferred embodiment of the invention, described semipermeable membrane 1 can select the semipermeable membrane purchased from Sefar company, and the material of described semipermeable membrane is nylon, and the aperture size in described hole 7 is 1 μm, 5 μm or 11 μm.
According to some of the preferred embodiment of the invention, in order to reach the object being convenient to stop blooding, described hemostasis bag 10 can be square, rectangle, bar-shaped or taper.When described hemostasis bag 10 be square or rectangle time, the length of described hemostasis bag 10 can be 1-20cm, and the width of described hemostasis bag 10 can be 1-20cm.When described hemostasis bag 10 be bar-shaped or taper time, those skilled in the art can select suitable size as required.
According to some of the preferred embodiment of the invention, as best shown in figures 3 a and 3b, described hemostasis bag 10 can be made into 3 × 3cm
2roughly square, the powder of described absorptive substance 2 is placed to centre or the center of semipermeable membrane 1, the edge of semipermeable membrane 1 sealed firmly (such as heat seal) to prevent the absorptive substance 2 stopped blooding in bag 10 from spilling or contaminated.
According to some of the preferred embodiment of the invention, absorptive substance 2 can be any applicable absorptive substance.Described absorptive substance 2 is super absorbent polymer preferably.Described super absorbent polymer can be selected from following a kind of or their combination: starch-series polymer, cellulose-based polymer and synthetic polymer based polymer.According to some of the preferred embodiment of the invention, the absorptive substance 2 in hemostasis bag can select main component to be polyacrylic super water absorption polymer powder.
Hemostasis provided by the invention can be used to wrap during the situation of any bleeding of skin in hospital or open air etc.Also under the press pressure be applicable to, hemostasis bag provided by the invention can be used in operation process.
Hemostasis bag provided by the present invention at least has the following advantages: the material of (1) hemostasis bag, especially the semipermeable membrane directly contacted with wound, be the polymer substance of synthetic, not containing the material extracted from organism, reduce the risk of sensitization and stimulation in hemostasis; (2) there is good anthemorrhagic performance; (3) unique selective absorbing mechanism is adopted, obviously different from the mechanism of existing hemostasia products.
hemostasis pushing assembly
According to some of the preferred embodiment of the invention, the present invention also provides a kind of hemostasis pushing assembly.
According to some of the preferred embodiment of the invention, see Fig. 5, described hemostasis pushing assembly 20 comprises following two parts: pressure providing unit 12 and hemostasis bag 10.Hemostasis bag 10 included by described hemostasis pushing assembly 20 and the aforementioned hemostasis provided of the present invention are wrapped 10 identical, therefore, are not repeated the concrete structure of hemostasis bag 10 at this.Described hemostasis bag 10 is arranged on or is connected in described pressure providing unit 12.Particularly, described hemostasis bag 10 can be arranged on or be connected in pressure providing unit 12 by bonding or the suitable mode such as bonding.
Hemostasis bag 10 in described hemostasis pushing assembly 20 is placed into bleeding part 6 place, hydrone 5 in blood is absorbed by absorptive substance 2 by the hole 7 of described semipermeable membrane 1, platelet 4 in blood and/or blood cell 3 are blocked in the side of semipermeable membrane 1 near bleeding part 6 by semipermeable membrane 1, therefore, described semipermeable membrane 1 improves the platelet 4 at bleeding part 6 place and/or the concentration of blood cell 3, thus accelerate the coagulation process of bleeding part 6, serve the effect accelerating hemostasis.Further, lasting and stable pressure can be provided to hemostasis bag 10 by the pressure providing unit 12 in hemostasis pushing assembly 20, pressure directly applies to be pressed onto to bleed on position by hemostasis bag 10, pressure energy reduces blood and flows out and the rheological characteristic of blood is changed, thus accelerates hemostasis further.
According to some of the preferred embodiment of the invention, described pressure providing unit 12 can have one or more following forms: (1) pressure bandage (such as, can select the 3MCoban pressure bandage buied from 3M company); (2) press belt (the 3MMultipore press belt buied from 3M company such as, can be selected); (3) aeration zone; (4) restraint device of pressure adjustable joint; (5) machinery of pressure is produced.
Hemostasis pushing assembly of the present invention at least has the following advantages: the material of the bag that stops blooding in (1) hemostasis pushing assembly, especially the semipermeable membrane directly contacted with wound, it is the polymer substance of synthetic, not containing the material extracted from organism, reduce the risk of sensitization and stimulation in hemostasis; (2) there is good anthemorrhagic performance; (3) unique selective absorbing mechanism is adopted, obviously different from the mechanism of existing hemostasia products.
hemostasis device
According to some of the preferred embodiment of the invention, the present invention also provides a kind of hemostasis device, and wherein, described hemostasis device comprises semipermeable membrane, and described semipermeable membrane has and stops platelet and/or hemocyte and the hole that hydrone is passed through.
The semipermeable membrane 1 of described hemostasis device is placed into bleeding part 6 place, hydrone 5 in blood is by the hole 7 of described semipermeable membrane 1, platelet 4 in blood and/or blood cell 3 are blocked in the side of semipermeable membrane 1 near bleeding part 6 by semipermeable membrane 1, therefore, described semipermeable membrane 1 improves the platelet 4 at bleeding part 6 place and/or the concentration of blood cell 3, thus accelerate the coagulation process of bleeding part 6, serve the effect accelerating hemostasis.
According to some of the preferred embodiment of the invention, as shown in Figure 2, described semipermeable membrane 1 can comprise the hole 7 of one or more rule or irregular alignment, and described hole 7 has and stops platelet and/or hemocyte and the aperture size that hydrone is passed through.Described platelet and/or hemocyte both can be platelet and/or the hemocyte of the mankind, also can be platelet and/or the hemocyte of other animal.Can by selecting the aperture size in the hole 7 of different semipermeable membrane 1, described semipermeable membrane 1 or the hemostasis device that comprises described semipermeable membrane 1 are applied in the hemostasis of the mankind or other different animals.
According to some of the preferred embodiment of the invention, described semipermeable membrane 1 can be anyly have the membrane material of the semi-transparent character in suitable hole, any braiding or non-woven materials with suitable hole, the medical film material preferably with the semi-transparent character in suitable hole, the braiding with suitable hole or non-woven medical material.According to some of the preferred embodiment of the invention, the aperture size in the hole 7 of described semipermeable membrane 1 is 0.01-15 μm, and such as described aperture size can be 1 μm, 5 μm or 11 μm.Because the diameter of the various hemocytees in human blood 3 (such as erythrocyte, leukocyte) is approximately 8-12 μm, the diameter of platelet 4 is about 5-8 μm, the diameter of hydrone is about 0.4nm, so the hydrone 5 in human blood is absorbed by absorptive substance 2 by the hole 7 of described semipermeable membrane 1, the platelet 4 in blood and/or blood cell 3 are blocked in the side of semipermeable membrane 1 near bleeding part 6 by semipermeable membrane 1.
According to some of the preferred embodiment of the invention, described semipermeable membrane 1 can select the semipermeable membrane purchased from Sefar company, and the material of described semipermeable membrane is nylon, and the aperture size in described hole 7 is 1 μm, 5 μm or 11 μm.
Hemostasis device of the present invention at least has the following advantages: the material in (1) hemostasis device, especially the semipermeable membrane directly contacted with wound, be the polymer substance of synthetic, not containing the material extracted from organism, reduce the risk of sensitization and stimulation in hemostasis; (2) there is good anthemorrhagic performance; (3) unique selective absorbing mechanism is adopted, obviously different from the mechanism of existing hemostasia products.
embodiment
Below with the form of embodiment, assessed the anthemorrhagic performance (in rabbit blood, platelet and/or hemocyte are similar to or are slightly less than platelet and/or hemocyte in human blood) of hemostasis bag provided by the invention by the test of rabbit live body spleen breach.
Embodiment 1
Rabbit weight being approximately 2kg faces upward and is placed on operating board, and by two back legs separately; Cut rabbit abdominal part, after exposing spleen, spleen surface is arranged a degree of depth is 1mm, length is the wound of 5mm.
By wrapping the mode applying 50g weight (being about 0.49 N) in hemostasis, hemostasis bag provided by the invention is placed and is fixed to wound site.In described hemostasis bag, semipermeable membrane is be the semipermeable membrane of nylon purchased from the material of Sefar company, and the hole of described semipermeable membrane is regular array, and the diameter in the hole of described semipermeable membrane is 11 μm; In described hemostasis bag, absorptive substance is the polyacrylic acid powder (model is SANFRESH YH-2) purchased from Sanyo company.
Every 5 minutes, remove described hemostasis bag and check wound location whether still Rupture haemorrhag.Carry out measurements and calculations bleeding stopping period with stopwatch, to place the time of hemostasis bag for the time started, with eye-observation to time of stopped bleeding for the end time:
Bleeding stopping period=end time-time started
Result of the test is listed in table 1 and Fig. 4, each result of the test is the meansigma methods of the bleeding stopping period of six tests.
Embodiment 2
Carry out rabbit live body spleen breach by the method identical with embodiment 1 to test, difference is, the diameter in the hole of described semipermeable membrane is 5 μm.
Result of the test is listed in table 1 and Fig. 6, each result of the test is the meansigma methods of the bleeding stopping period of six tests.
Embodiment 3
Carry out rabbit live body spleen breach by the method identical with embodiment 1 to test, difference is, the diameter in the hole of described semipermeable membrane is 1 μm.
Result of the test is listed in table 1 and Fig. 4, each result of the test is the meansigma methods of the bleeding stopping period of six tests.
Comparative example 1
Rabbit weight being approximately 2kg faces upward and is placed on operating board, and by two back legs separately; Cut rabbit abdominal part, after exposing spleen, spleen surface is arranged a degree of depth is 1mm, length is the wound of 5mm.
By applying the mode of 50g weight (being about 0.49 N) on common gauze, common gauze being placed and is fixed to wound site.Described common gauze is the degreasing cotton gauze purchased from Hai Honglong medical supplies equipment company limited.
Every 5 minutes, remove described common gauze and check wound location whether still Rupture haemorrhag.Carry out measurements and calculations bleeding stopping period with stopwatch, to place the time of common gauze for the time started, with eye-observation to time of stopped bleeding for the end time:
Bleeding stopping period=end time-time started
Result of the test is listed in table 1 and Fig. 4, each result of the test is the meansigma methods of the bleeding stopping period of six tests.
Table 1 rabbit live body spleen breach is tested
From table 1 and Fig. 4, in the test of rabbit live body spleen breach, use the bleeding stopping period of hemostasis bag provided by the invention much smaller than the bleeding stopping period using common gauze, so hemostasis provided by the invention bag has better anthemorrhagic performance than common gauze.In addition, along with hemostasis bag in semipermeable membrane hole aperture size successively decrease (11 μm, 5 μm, 1 μm), bleeding stopping period also shortens thereupon, and this illustrates in the scope of certain aperture size, and the semipermeable membrane with the hole of more small pore size can stop passing through of platelet and/or hemocyte better, the concentrated effect of blood is better, and therefore the hemostasis bag with the semipermeable membrane in the hole of more small pore size also possesses better haemostatic effect.
Below with the form of embodiment, assessed the anthemorrhagic performance (in rabbit blood, platelet and/or hemocyte are similar to or are slightly less than platelet and/or hemocyte in human blood) of hemostasis pushing assembly provided by the invention by rabbit live body femoral artery notch test.
Embodiment 4
Rabbit weight being approximately 2kg faces upward and is placed on operating board, and by two back legs separately; The skin of rabbit is cut off, and cuts muscle to expose and isolation femoral artery; Use scissors for surgery, cutting femoral artery is bled to produce (cutting wound is about 1/3rd of blood vessel thickness).
Hemostasis pushing assembly provided by the invention comprises hemostasis bag and pressure providing unit.Can be placed by hemostasis pushing assembly by pressure providing unit and be fixed to wound site, the pressure that hemostasis pushing assembly provides be about 50g pressure (being about 0.49 N).Semipermeable membrane in described hemostasis bag is be the semipermeable membrane of nylon purchased from the material of Sefar company, the hole of described semipermeable membrane is regular array, the diameter in the hole of described semipermeable membrane is 5 μm, absorptive substance in described hemostasis bag is the polyacrylic acid powder (model is SANFRESH YH-2) purchased from Sanyo company, and described pressure providing unit is pressure bandage (such as can select the 3M Coban buied from 3M company).
Every 5 minutes, remove hemostasis pushing assembly and check wound location whether still Rupture haemorrhag.Carry out measurements and calculations bleeding stopping period with stopwatch, to place the time of gauze for the time started, with eye-observation to time of stopped bleeding for the end time
Bleeding stopping period=end time-time started
Result of the test is listed in table 2 and Fig. 6, each result of the test is the meansigma methods of the bleeding stopping period of six tests.
Comparative example 2
Rabbit weight being approximately 2kg faces upward and is placed on operating board, and by two back legs separately; The skin of rabbit is cut off, and cuts muscle to expose and isolation femoral artery; Use scissors for surgery, cutting femoral artery is bled (wound is about 1/3rd of blood vessel thickness) to produce.
By applying the mode of 50g weight (being about 0.49 N) on common gauze, common gauze being placed and is fixed to wound site.Described common gauze is the degreasing cotton gauze purchased from Hai Honglong medical supplies equipment company limited.
Every 5 minutes, remove common gauze and check wound location whether still Rupture haemorrhag.Carry out measurements and calculations bleeding stopping period with stopwatch, to place the time of common gauze for the time started, with eye-observation to time of stopped bleeding for the end time
Bleeding stopping period=end time-time started
Result of the test is listed in table 2 and Fig. 6, each result of the test is the meansigma methods of the bleeding stopping period of six tests.
Comparative example 3
Rabbit weight being approximately 2kg faces upward and is placed on operating board, and by two back legs separately; The skin of rabbit is cut off, and cuts muscle to expose and isolation femoral artery; Use scissors for surgery, cutting femoral artery is bled to produce (cutting wound is about 1/3rd of blood vessel thickness).
By applying the mode of 50g weight (being about 0.49 N) on QuikClot, QuikClot being placed and is fixed to wound site.Described QuikClot is be kaolinic QuikClot hemostasia products purchased from the effective ingredient of Z-Medica company.
Every 5 minutes, remove QuikClot and check wound location whether still Rupture haemorrhag.Carry out measurements and calculations bleeding stopping period with stopwatch, to place the time of QuikClot for the time started, with eye-observation to time of stopped bleeding for the end time
Bleeding stopping period=end time-time started
Result of the test is listed in table 2 and Fig. 6, each result of the test is the meansigma methods of the bleeding stopping period of six tests.
Table 2 rabbit live body femoral artery notch test
From table 2 and Fig. 6, in rabbit live body femoral artery notch test, use the bleeding stopping period of hemostasis pushing assembly provided by the invention not only much smaller than the bleeding stopping period using common gauze, and than shorter to the bleeding stopping period of large artery trunks anthemorrhagic performance good QuikClot hemostasia products in prior art, so hemostasis pushing assembly provided by the invention has better anthemorrhagic performance than common gauze and QuikClot.
Although describe the present invention by reference to the accompanying drawings, embodiment disclosed in accompanying drawing is intended to carry out exemplary illustration to the preferred embodiment for the present invention, and can not be interpreted as one restriction of the present invention.
Although some embodiments of general plotting of the present invention have been shown and explanation, those skilled in the art will appreciate that, when not deviating from principle and the spirit of this present general inventive concept, can make a change these embodiments, scope of the present invention is with claim and their equivalents.
Claims (13)
1. a hemostasis bag, wherein, described hemostasis handbag is drawn together:
Semipermeable membrane, described semipermeable membrane has and stops platelet and/or hemocyte and the hole that hydrone is passed through; With
Absorptive substance, described absorptive substance is arranged on the opposite side that described semipermeable membrane stops platelet and/or hemocyte side, for the moisture in the blood at absorption bleeding part, the hole place through described semipermeable membrane, thus plays the effect accelerating hemostasis.
2. a hemostasis bag, wherein, described hemostasis handbag is drawn together:
At least one semi-transparent rete, described semi-transparent rete has and stops platelet and/or hemocyte and the hole that hydrone is passed through; With
Absorptive substance, described absorptive substance is clamped in the center of semi-transparent rete or the centre of semi-transparent rete, for the moisture in the blood at absorption bleeding part, the hole place through described semi-transparent rete, thus plays the effect accelerating hemostasis.
3. hemostasis bag according to claim 1 and 2, wherein,
The aperture size in described hole is 0.01-15 μm.
4. hemostasis bag according to claim 1 and 2, wherein,
Described semipermeable membrane is have the medical weaved film of semi-transparent character or have the medical adhesive-bonded fabric membrane material of semi-transparent character.
5. hemostasis bag according to claim 1 and 2, wherein
Described absorptive substance is arranged to the form of powder, granule, fiber, pad or layer in hemostasis bag.
6. hemostasis bag according to claim 1 and 2, wherein,
Described hemostasis bag is square or rectangle, and its length is 1-20cm, and width is 1-20cm.
7. hemostasis bag according to claim 1 and 2, wherein,
Described hemostasis bag is bar-shaped or vertebra shape.
8. hemostasis bag according to claim 1 and 2, wherein,
The edge of described hemostasis bag is sealed firmly to make the material in hemostasis bag not spill.
9. hemostasis bag according to claim 1 and 2, wherein,
Described absorptive substance is super absorbent polymer, and is by a kind of of following middle selection or their combination: starch-series polymer, cellulose-based polymer and synthetic polymer based polymer.
10. a hemostasis pushing assembly, wherein, described hemostasis pushing assembly comprises:
Pressure providing unit, and
Hemostasis bag according to any one of claim 1-9, described hemostasis bag is arranged on or is connected in described pressure providing unit.
11. hemostasis pushing assemblies according to claim 10, wherein,
Described pressure providing unit is pressure bandage, press belt, aeration zone, the restraint device of pressure adjustable joint or the machinery of generation pressure.
12. 1 kinds of hemostasis devices, wherein, described hemostasis device comprises:
Semipermeable membrane, described semipermeable membrane has and stops platelet and/or hemocyte and the hole that hydrone is passed through.
13. hemostasis devices according to claim 12, wherein,
The aperture size in the hole of described semipermeable membrane is 0.01 ~ 15 μm.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310235177.5A CN104224269A (en) | 2013-06-14 | 2013-06-14 | Hemostasis bag, hemostasis pressing assembly and hemostasis device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310235177.5A CN104224269A (en) | 2013-06-14 | 2013-06-14 | Hemostasis bag, hemostasis pressing assembly and hemostasis device |
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| CN104224269A true CN104224269A (en) | 2014-12-24 |
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| CN201310235177.5A Pending CN104224269A (en) | 2013-06-14 | 2013-06-14 | Hemostasis bag, hemostasis pressing assembly and hemostasis device |
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