CN104171540B - A kind of weanling pig anti-diarrhea growth-promoting changqiang immunity compound Chinese herbal medicinal feed additive and preparation method thereof - Google Patents
A kind of weanling pig anti-diarrhea growth-promoting changqiang immunity compound Chinese herbal medicinal feed additive and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of weanling pig anti-diarrhea growth-promoting changqiang immunity compound Chinese herbal medicinal feed additive and preparation method thereof. Described weanling pig anti-diarrhea growth-promoting changqiang immunity compound Chinese herbal medicinal feed additive, comprises the component of following parts by weight: Fruticose Breyniae Leaf and Twig 8-12 part, Chinese knotweed 8-12 part, granatum 7-11 part, common lantana root 7-11 part, metastoma dodecandum lour 6-10 part, rhizome of cyrtomium 5-9 part, dark plum 5-9 part, stir-baked FRUCTUS CRATAEGI 5-9 part, matrimony vine 4-8 part, mountain, Huaihe River 4-8 part, Divine Comedy 4-8 part, banksia rose 3-7 part, wrinkled giant hyssop 3-7 part, Radix Glycyrrhizae 3-7 part. The present invention can effectively prevent weanling pig to suffer from diarrhoea, and strengthens immunity, improves the speed of growth.
Description
Technical field
The present invention relates to a kind of compound Chinese herbal medicinal feed additive and preparation method thereof, relate in particular to a kind of weanling pig anti-Diarrhoea growth promotion and enhancing immunity compound Chinese herbal medicinal feed additive and preparation method thereof.
Background technology
Pork is the edible maximum and the most widely used meat products of China people, and raising pigs, it is very important to become in agriculturalIndustry, in agricultural structure adjustment, played the part of key player, for increasing farmers' income and making the rural economy flourish and madeSignificant contribution; In addition, the supply security of pork and Quality Safety have greatly been related to the steady of our lives to a certain extentQualitative and Happiness Index height. The phenomenon that diarrhoea occurs weanling pig is very general and multiple, and has the trend rising year by year,Have a strong impact on piglet survival ratio, cause great economic loss, the direct economic loss that especially this 2 years grice diarrhoeas cause is highReach several hundred million yuans, affect the sound development of the stable and pig industry of pig valency. But meanwhile, preventing and treating every year grice diarrhoea usesA large amount of antibiotic medicines, companion's and medicament residue and resistance problem, the harm that the environment of depending on for existence to the mankind brings is moreTo be difficult to estimate.
Along with the raising of social progress, living standards of the people and the enhancing of self health consciousness, people are selecting livestock and poultryWhen product, not only require it nutritious, and require safety, health, health care, wherein the most basic one is antibiotic-free medicineThing is residual. China joins WTO already, and the international market paces of animal products are further accelerated, and develop nuisanceless animal husbandry, rawProduce green livestock products, strengthen the competitiveness in the international market of China's livestock products, become the top priority of China's animal husbandry. AsOne big country of raising pigs, China's number of animals raised accounts for 49% of the world, but live pig and products thereof outlet only accounts for 1%, and master traces it to its causeEssential factor is the outlet of medicament residue problem restriction China swine products of epidemic disease problem and antibiotics additive, and restriction China is rawThe development of pig industry. In recent years, many countries successively makes the regulation that limits the use of or forbid chemical synthetic drug and do feed addictive,The also various antibiotic of cancellation and chemical synthesis class additive progressively of China. Therefore, searching may substitute antibacterials andThe drug residue free of the short long agent of chemistry, have no drug resistance, have no side effect, and effectively the somatotrophic feed addictive of anti diar rhea is nearThe subject under discussion that Nian Laishen is paid close attention to by people, wherein Chinese herbal medicine becomes the important research object of domestic and international Substitutes For Antibiotic.
Chinese herbal feed additive is safe and harmless because of it, and toxic and side effect is little, seldom residual, without the resistance to the action of a drug, can urge equallyEnter the growth of pig and the effect of preventing and curing diseases, day by day come into one's own, and tested widely and use, so the Ministry of AgricultureNo. 1773 bulletins allow will exceed 120 kinds of natural plants as forage plant raw material. Chinese herbal medicine and food homology, have naturalThe globality of property, effect and amphicheirality, toxic and side effect be less, be difficult for developing immunity to drugs and form seldom in vivo hazard residueFeature. Therefore,, under the world trends impact of " back to nature ", Chinese herbal medicine is just gradually at home and abroad by increasing people instituteAccept. Especially Chinese herbal medicine and extract thereof, in the control of chronic disease, tumour, cancer and viral disease etc., have chemistryThe synthetic incomparable effect of class medicine, and make Chinese herbal medicine move towards to internationalize to have obtained new opportunity. Although some more wide spectrum,Act on stronger antibacterials and developed successively, but the research and development of new antimicrobial agent obviously do not catch up with the speed that antibody-resistant bacterium producesDegree, and time and cost that new antibacterials of development spend are all very big. Chinese herbal medicine is China for thousands of yearsAnd even the people people of the world's health has been made major contribution, aspect modern times prevention and control bacterial infection disease, also sending outWave positive role. In view of the natural sex of Chinese herbal medicine, have environmentally safe, relative costs is cheap, on animal application specialThe features such as edible animal application is safer, Chinese herbal medicine in live pig healthy aquaculture, keep healthy and control and prevention of disease aspect also have veryWide prospect.
Therefore, be necessary to provide a kind of compound Chinese herbal medicinal feed additive and preparation method thereof, young to reach prevention weanDiarrhea of pigs, enhancing resistance against diseases, the speed of growth that improves, the effect of promotion health cultivation.
Summary of the invention
The object of this invention is to provide one can preventing post-weaning diarrhea, improve the speed of growth, strengthen immunocompetence,And then the compound Chinese herbal medicinal feed additive of promotion health cultivation and preparation method thereof.
For achieving the above object, the technical solution used in the present invention is as follows:
A kind of preventing post-weaning diarrhea growth-promoting changqiang immunity compound Chinese herbal medicinal feed additive, comprises following parts by weightComponent: Fruticose Breyniae Leaf and Twig 8-12 part, Chinese knotweed 8-12 part, granatum 7-11 part, common lantana root 7-11 part, metastoma dodecandum lour 6-10 part, passes throughMany 5-9 parts, dark plum 5-9 part, stir-baked FRUCTUS CRATAEGI 5-9 part, matrimony vine 4-8 part, mountain, Huaihe River 4-8 part, Divine Comedy 4-8 part, banksia rose 3-7 part, wrinkled giant hyssop 3-7Part, Radix Glycyrrhizae 3-7 part.
In a preferred embodiment, comprise the component of following parts by weight: 10 parts of Fruticose Breyniae Leaf and Twigs, 10 parts of Chinese knotweeds, stone9 parts of pomegranate skins, 9 parts of common lantana roots, 8 parts of metastoma dodecandum lours, 7 parts of rhizome of cyrtomium, 7 parts of dark plums, 7 parts of stir-baked FRUCTUS CRATAEGIs, 6 parts of matrimony vines, 6 parts, mountain, Huaihe River, Divine Comedy 6Part, 5 parts of the banksia rose, 5 parts of wrinkled giant hyssops, 5 parts, Radix Glycyrrhizae.
A method of preparing above-mentioned compound Chinese herbal medicinal feed additive, comprises the following steps: by above-mentioned raw materials by above-mentionedRatio can make after mixing, pulverizing.
The above-mentioned method of preparing compound Chinese herbal medicinal feed additive, can also be more specifically: get sheet hawthorn, at boilerIn cure into sallowly, obtain stir-baked FRUCTUS CRATAEGI, then described stir-baked FRUCTUS CRATAEGI is mixed according to the above ratio with above-mentioned other raw materials, first use 40 ordersElementary pulverizing, then pulverizes with 100 orders, can make.
When use by described compound Chinese herbal medicinal feed additive according to the 2-2.5wt's ‰ of weanling pig basal feed weightRatio is added in weanling pig basal feed, through fodder machine mixing granulation.
A kind of weanling pig feed, comprises weanling pig basal feed and accounts for above-mentioned weanling pig basal feed weightThe weanling pig compound Chinese herbal medicinal feed additive of 2-2.5wt ‰, described weanling pig compound Chinese herbal medicinal feed additive comprisesThe component of following parts by weight: Fruticose Breyniae Leaf and Twig 8-12 part, Chinese knotweed 8-12 part, granatum 7-11 part, common lantana root 7-11 part, brocade groundSieve 6-10 part, rhizome of cyrtomium 5-9 part, dark plum 5-9 part, stir-baked FRUCTUS CRATAEGI 5-9 part, matrimony vine 4-8 part, mountain, Huaihe River 4-8 part, Divine Comedy 4-8 part, banksia rose 3-7 parts, wrinkled giant hyssop 3-7 part, Radix Glycyrrhizae 3-7 part.
Wherein, described weanling pig basal feed is the conventional basal feeds of those skilled in the art, specifically fills a prescription and seeksFoster level is:
This compound Chinese herbal medicine additive has following 4 significant advantage features: 1, this compound is made up of pure Chinese herbal medicine, proportioningScience, effect are remarkable, can have prevention of diarrhea in piglets simultaneously, promote growth, strengthen the multiple remarkable efficacy such as immunity, use peaceEntirely, noresidue and toxic and side effect, can reduce or the use of substitute antibiotics, meet green health cultivation theory. 2, this compound choosingWith Chinese herbal medicine be routine, the medicinal material that is easy to get, use cost is low, except Common Chinese Herbs, has also selected southern common, medicinalBe worth height unheeded Chinese herbal medicine, both developed local Chinese medicinal herbs, reduced again the awkward situation to striving medicine with people.3, this compound Chinese herb prescription is according to the composition principle of Chinese medicine monarch, again in conjunction with the specific physiology growth of weanling pigFeature and designing, can better solve preventing post-weaning diarrhea, growth promotion and strengthen immunity etc. problem. 4, this compound medium-height grassMedicine composition principle is, in this compound Fruticose Breyniae Leaf and Twig, Chinese knotweed, granatum, common lantana root, metastoma dodecandum lour, rhizome of cyrtomium etc. have clearing heat and detoxicating,Effect of anti-inflammation, antidysentery with astringent, is monarch drug in a prescription, mainly prevents and treat the most incidental diarrhoea problem of weanling pig;In this compound, dark plum, stir-baked FRUCTUS CRATAEGI, matrimony vine have effect of the puckery intestines of astringing the lung, promoting production of body fluid and inducing sedation of the mind, appetite-stimulating indigestion-relieving, antipyretic cough-relieving, are ministerial drug,Main promote piglet to search for food, alleviate ablactation stress, prevention to cough and breathe heavily and improve immunity of organisms. Huai Shan, Divine Comedy, wood in this compoundEffect that fragrant, wrinkled giant hyssop has reinforcing spleen to promote digestion, clearing damp and promoting diuresis, eliminates dampness with aromatics, is adjutant, mainly improves piglet digestive function, preventsThe side effect such as constipation, abdominal distension that puckery intestines cause. Radix Glycyrrhizae in this compound, property sugariness is flat, and coordinating the drug actions of a prescription, for making medicine. The all medicines of this compoundShare, except thering is effect of significantly pre-anti-diarrhea, promote in addition the good effect of piglet growth, enhancing piglet immunity of organismsReally.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is done to detailed description further, but embodiments of the present invention are not limited toThis.
Embodiment 1: extracorporeal bacteria inhibitor test
Take according to following parts by weight: 8 parts of Fruticose Breyniae Leaf and Twigs, 8 parts of Chinese knotweeds, 7 parts of granatums, 7 parts of common lantana roots, metastoma dodecandum lour6 parts, 5 parts of rhizome of cyrtomium, 5 parts of dark plums, 5 parts of stir-baked FRUCTUS CRATAEGIs, 4 parts of matrimony vines, 4 parts, mountain, Huaihe River, 4 parts of Divine Comedy, 3 parts of the banksia rose, 3 parts of wrinkled giant hyssops, Radix Glycyrrhizae 3Part; Then first by sheet hawthorn, in boiler, cure into sallow stir-baked FRUCTUS CRATAEGI, then by stir-baked FRUCTUS CRATAEGI and above-mentioned other raw material in proportionMix, with appropriate distilled water immersion, slow fire boiling, the dregs of a decoction add appropriate distilled water again and decoct, and merge twice decocting liquid suitably dense againContracting, makes the liquid being about containing former medicine 0.2g/mL, then by liquid dilute respectively for 0.2g/mL, 0.15g/mL, 0.1g/mL,Tetra-gradients of 0.05g/mL, carry out drug sensitivity testing in vitro. Supply to try coli strains respectively at Mai Kangkai by different 5 strains of preservingStreak inoculation on agar plate, cultivation, then picking colonies typical is cultivated to MH meat soup, and to adjust concentration be 0.5 MaxwellConcentration, sterilized cotton swabs dips bacterium liquid and is evenly coated with MH agar, then the Oxford cup of sterilizing is placed on the MH agar of coating bacterium liquid, lightPress, every glass adds 200 μ L liquids, puts after 37 DEG C of incubators are cultivated 18-24h and measures antibacterial circle diameter, antibacterial circle diameter > 8mm(Oxford cup external diameter), is judged to effectively. The result of this experiment is as following table 1:
Extracorporeal bacteria inhibitor test is tested and is shown, the extract of this compound Chinese herb all has obviously the different Escherichia coli that separateFungistatic effect.
Embodiment 2: anti-diarrhea growth promotion test in body
Take according to following parts by weight: 12 parts of Fruticose Breyniae Leaf and Twigs, 12 parts of Chinese knotweeds, 11 parts of granatums, 11 parts of common lantana roots, brocade10 parts of ground sieve, 9 parts of rhizome of cyrtomium, 9 parts of dark plums, 9 parts of stir-baked FRUCTUS CRATAEGIs, 8 parts of matrimony vines, 8 parts, mountain, Huaihe River, 8 parts of Divine Comedy, 7 parts of the banksia rose, 7 parts of wrinkled giant hyssops, sweet7 parts of grass; Then first by sheet hawthorn, in boiler, cure into the sallow stir-baked FRUCTUS CRATAEGI that obtains, then by mixed to stir-baked FRUCTUS CRATAEGI and above-mentioned other raw materialClose, first use the elementary pulverizing of 40 order, then pulverize with 100 orders, make finished product, according to weanling pig basal feed weightThe ratio of 2.5wt ‰ is added in weanling pig basal feed formula, becomes perfect compound feed through fodder machine mixing granulation.
Perfect compound feed protein content >=18.0% that the present embodiment is made, fat content >=2.5%, can meet weanThe nutritional requirement of piglet. 80 piglets are selected in test, are divided into totally 4 groups of A, B, C, D, 20 every group, respectively organize average weight and are respectively AGroup 10.88kg, B group 10.62kg, C group 10.81kg, D group 10.72kg, wherein A group, B group are experimental group, the compound Chinese herb of feedingFeed addictive coordinates weanling pig basal feed, and C group, D group are control group, the weanling pig basal feed of feeding. Test periodIt is 10 days. Record each group of average " daily ingestion amount ", " daily gain ", " material anharmonic ratio ", " diarrhea rate " etc.
Wherein " daily ingestion amount ", taking every hurdle as unit, records the total amount of searching for food on every hurdle, then divided by every hurdle head number and test dayNumber, obtains on average " daily ingestion amount "; " daily gain ", taking a hurdle as unit, records the total augment weight on every hurdle, then divided by every hurdle head number and examinationTest number of days, obtain on average " daily gain "; " material anharmonic ratio "=daily ingestion amount/daily gain; The total head of " diarrhea rate "=100% × diarrhoea pigletInferior/(live-stock inventory × test number of days), diarrhoea piglet to show as loose and watery stool pasty state, feed excrement, water sample just rare. The knot of this experimentReally as following table 2:
Experiment shows, the Chinese herb feed additive experimental group of having fed and the control group phase that uses weanling pig basal feed daily rationRatio, in the first inapparent situation of counterpoise difference, experimental group is better than control group aspect day counterpoise, daily ingestion amount, material anharmonic ratio, andSignificant difference (P < 0.05); At most important anti diar rhea aspect of performance, experimental group is much better than experimental group, and difference is (P < extremely significantly0.01). Illustrate that the Chinese herb feed additive of this experiment use is in production performances such as prevention of diarrhea in piglets and raising piglet growth speedAspect effect is good.
Embodiment 3: strengthen body immunity test in body
Take according to following parts by weight: 10 parts of Fruticose Breyniae Leaf and Twigs, 10 parts of Chinese knotweeds, 9 parts of granatums, 9 parts of common lantana roots, brocade ground8 parts of sieve, 7 parts of rhizome of cyrtomium, 7 parts of dark plums, 7 parts of stir-baked FRUCTUS CRATAEGIs, 6 parts of matrimony vines, 6 parts, mountain, Huaihe River, 6 parts of Divine Comedy, 5 parts of the banksia rose, 5 parts of wrinkled giant hyssops, Radix Glycyrrhizae 5Part; Then first by sheet hawthorn, in boiler, cure into sallow stir-baked FRUCTUS CRATAEGI, then stir-baked FRUCTUS CRATAEGI is mixed with above-mentioned other raw material,First use the elementary pulverizing of 40 order, then pulverize with 100 orders, make finished product, according to 2wt ‰ ratio of weanling pig basal feed weightBe added in weanling pig basal feed formula, become perfect compound feed through fodder machine mixing granulation.
Perfect compound feed protein content >=18.0% that the present embodiment is made, fat content >=2.5%, can meet weanThe nutritional requirement of piglet. 30 piglets are selected in test, are divided into two groups of A, B, 15 every group, respectively organize average weight and are respectively A group11.51kg, B organize 11.47kg, and wherein A group is experimental group, and the Chinese herb feed additive of feeding coordinates weanling pig basal feed, and B group isControl group, the weanling pig basal feed of feeding, test period is 30 days. Two groups of the 7th day immune swine fevers after on-test of A, BST cell vaccine, the 14th day immune swine circovirus type II inactivated vaccine, within the 30th day, vena cava anterior gathers separation of serum, uses respectively the U.S.Ai Deshi ELISA kit detects swine fever, pig gyrate virus II type antibody, and surveys by α-naphthyl acetate esterase (ANAE) decoration methodThe method of determining detects T lymphocyte percentage. The result of this experiment is as following table 3-5:
This experiment shows, the Chinese herb feed additive experimental group of having fed and the control group that uses weanling pig basal feed daily rationCompare, in identical vaccine immunity situation, the hog cholera antibody of Chinese herb feed additive experimental group, porcine circovirus 2 type antibody are sun entirelyProperty, and control group still has minority to be negative; Two kinds of antibody mean values of Chinese herb feed additive experimental group all higher than or be significantly higher than rightAccording to group (P < 0.05 or P < 0.01), experimental group antibody dispersion, all significantly lower than control group, shows that regularity is high, meanwhile, rightBe significantly higher than control group (P < 0.01) according to the group T lymphocyte percentage utmost point. In synthesis, immunity test shows, compound Chinese herbAdditive can effectively improve immunity of organisms and the general level of the health.
Wherein, embodiment 2 with the formula of the weanling pig basal feed described in embodiment 3 is:
As mentioned above, can realize preferably the present invention.
The above, be only preferred embodiment of the present invention, not the present invention done to any pro forma restriction, complies withAccording to technical spirit of the present invention, within the spirit and principles in the present invention, any simple amendment that above embodiment is done,Be equal to replacement and improvement etc., within all still belonging to the protection domain of technical solution of the present invention.
Claims (5)
1. a weanling pig compound Chinese herbal medicinal feed additive, is characterized in that, is made up of: black the component of following parts by weightFace god 8-12 part, Chinese knotweed 8-12 part, granatum 7-11 part, common lantana root 7-11 part, metastoma dodecandum lour 6-10 part, rhizome of cyrtomium 5-9 part, crowPlum 5-9 part, stir-baked FRUCTUS CRATAEGI 5-9 part, matrimony vine 4-8 part, mountain, Huaihe River 4-8 part, Divine Comedy 4-8 part, banksia rose 3-7 part, wrinkled giant hyssop 3-7 part, Radix Glycyrrhizae 3-7Part.
2. a weanling pig compound Chinese herbal medicinal feed additive, is characterized in that, is made up of: black the component of following parts by weight10 parts of face god, 10 parts of Chinese knotweeds, 9 parts of granatums, 9 parts of common lantana roots, 8 parts of metastoma dodecandum lours, 7 parts of rhizome of cyrtomium, 7 parts of dark plums, stir-baked FRUCTUS CRATAEGI 7Part, 6 parts of matrimony vines, 6 parts, mountain, Huaihe River, 6 parts of Divine Comedy, 5 parts of the banksia rose, 5 parts of wrinkled giant hyssops, 5 parts, Radix Glycyrrhizae.
3. prepare a method for weanling pig compound Chinese herbal medicinal feed additive as claimed in claim 1 or 2, its feature existsIn, comprise the following steps: after above-mentioned raw materials is mixed according to the above ratio, pulverized, can make.
4. a weanling pig feed, is characterized in that, comprises weanling pig basal feed and accounts for described weanling pig basisThe weanling pig compound Chinese herbal medicinal feed additive of the 2-2.5wt ‰ of feed weight, described weanling pig compound Chinese herb feedAdditive is made up of the component of following parts by weight: Fruticose Breyniae Leaf and Twig 8-12 part, Chinese knotweed 8-12 part, granatum 7-11 part, Lantana camaraRoot 7-11 part, metastoma dodecandum lour 6-10 part, rhizome of cyrtomium 5-9 part, dark plum 5-9 part, stir-baked FRUCTUS CRATAEGI 5-9 part, matrimony vine 4-8 part, mountain, Huaihe River 4-8 part, godBent 4-8 part, banksia rose 3-7 part, wrinkled giant hyssop 3-7 part, Radix Glycyrrhizae 3-7 part.
5. weanling pig feed as claimed in claim 4, is characterized in that, described weanling pig basal feed comprises: corn,Dregs of beans, expanded soybean, whey powder, fish meal, sucrose, stone flour, calcium monohydrogen phosphate, acidulant, premix.
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| CN111011627A (en) * | 2019-12-18 | 2020-04-17 | 成都大帝汉克生物科技有限公司 | Feed additive capable of preventing diarrhea and preparation method thereof |
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| CN101731488A (en) * | 2010-01-07 | 2010-06-16 | 上海交通大学 | Chinese medicinal herb additive for preventing post-weaning diarrhea and pig feed thereof |
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| CN103109980A (en) * | 2013-03-05 | 2013-05-22 | 聊城大学 | Chinese herbal medicine feed additive capable of improving immunity, preparation method thereof and feed |
| CN103829108A (en) * | 2014-03-26 | 2014-06-04 | 山东新希望六和集团有限公司 | Chinese medicine additive for promoting piglet growth and preparation method thereof |
| CN103859208A (en) * | 2014-02-18 | 2014-06-18 | 四川绿牧农业有限公司 | Piglet health protection fodder and preparation method thereof |
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| CN101731488A (en) * | 2010-01-07 | 2010-06-16 | 上海交通大学 | Chinese medicinal herb additive for preventing post-weaning diarrhea and pig feed thereof |
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Effective date of registration: 20160408 Address after: Xin GUI Guangzhou high tech Industrial Development Zone, Guangdong province Guangzhou city two road 510530 No. 56 Applicant after: GUANGZHOU HINTER BIOTECHNOLOGY CO., LTD. Address before: 511473 west side of Xiqiao bridge, Tung Chung Town, Guangzhou, Nansha District, Guangdong Applicant before: Da-chuan Panyu in Guangzhou City Panyu Da-chuan Feed Co., Ltd. |
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